CO4910132A1 - Agonistas adrenergicos selectivos de beta 3 - Google Patents
Agonistas adrenergicos selectivos de beta 3Info
- Publication number
- CO4910132A1 CO4910132A1 CO97051043A CO97051043A CO4910132A1 CO 4910132 A1 CO4910132 A1 CO 4910132A1 CO 97051043 A CO97051043 A CO 97051043A CO 97051043 A CO97051043 A CO 97051043A CO 4910132 A1 CO4910132 A1 CO 4910132A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- hydrogen
- bond
- beta
- adrenergic agonists
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El uso de un compuesto de Fórmula I para estimular elreceptor ß3 :en la que:X1 es -OCH2 -, -SCH2 - o un enlace;X2 es un enlace, o un alquileno lineal o ramificado de 1 a 5 carbonos;X3 es O, S o un enlace;R1 es un heterociclo condensado de la fórmula:los grupos A1 son, independientemente, carbono o nitrógeno, con la condición de que no pueden estar incluidos más de 2 nitrógenos en ningún anillo condensado de 6 miembros, y de que esos 2 nitrógenos no pueden ser adyacentes;R2 es, independientemente, hidrógeno, alquilo C1 -C4 o arilo;R3 es, hidrógeno, alquilo C1 -C4 ;R4 es, un heterociclo opcionalmente sustituido, o un radical seleccionado entre el grupo compuesto por:R5 es hidrógeno o alquilo C1 -C4 ;R6 es hidrógeno o alquilo C1 -C4 ; oo R5 y R6 se combinan con el carbono al que está unido cada uno, ...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2581896P | 1996-09-05 | 1996-09-05 | |
US2922896P | 1996-10-30 | 1996-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4910132A1 true CO4910132A1 (es) | 2000-04-24 |
Family
ID=26700197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO97051043A CO4910132A1 (es) | 1996-09-05 | 1997-09-03 | Agonistas adrenergicos selectivos de beta 3 |
Country Status (13)
Country | Link |
---|---|
US (4) | US6140352A (es) |
EP (1) | EP0827746B1 (es) |
JP (1) | JP4212117B2 (es) |
AR (2) | AR009518A1 (es) |
AT (1) | ATE215369T1 (es) |
AU (1) | AU4094197A (es) |
CO (1) | CO4910132A1 (es) |
DE (1) | DE69711519T2 (es) |
ES (1) | ES2171839T3 (es) |
ID (1) | ID17182A (es) |
MY (1) | MY132626A (es) |
PE (1) | PE109398A1 (es) |
WO (1) | WO1998009625A1 (es) |
Families Citing this family (61)
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ATE215369T1 (de) * | 1996-09-05 | 2002-04-15 | Lilly Co Eli | Carbazolanaloge als selektive beta3-adrenergische agonisten |
JP2001525398A (ja) * | 1997-12-05 | 2001-12-11 | イーライ・リリー・アンド・カンパニー | 選択的β3アドレナリン作動性アゴニスト |
CO5011072A1 (es) * | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
KR20010080761A (ko) * | 1998-12-15 | 2001-08-22 | 야마모토 카즈모토 | 신규한 복소환 화합물 및 이를 함유하는 의약 조성물 |
WO2001007025A2 (en) * | 1999-07-22 | 2001-02-01 | Eli Lilly And Company | Treatment of cardiac abnormalities with aryloxy propanolamines |
WO2001007026A2 (en) * | 1999-07-22 | 2001-02-01 | Eli Lilly And Company | Improved method of treating type ii diabetes and obesity |
WO2001035947A2 (en) * | 1999-11-15 | 2001-05-25 | Eli Lilly And Company | Treating wasting syndromes with aryloxy propanolamines |
JP2003514815A (ja) * | 1999-11-15 | 2003-04-22 | イーライ・リリー・アンド・カンパニー | 家畜生産を改良するためのアリ−ルオキシプロパノロールアミン |
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ES2301142T3 (es) | 2000-01-21 | 2008-06-16 | Novartis Ag | Combinaciones que comprenden inhibidores de dipeptidilpeptidasa-iv y agentes antidiabeticos. |
EP1258253A1 (en) * | 2000-01-28 | 2002-11-20 | Asahi Kasei Kabushiki Kaisha | Novel remedies with the use of beta3 agonist |
AUPQ585000A0 (en) * | 2000-02-28 | 2000-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
NZ521386A (en) * | 2000-03-15 | 2004-06-25 | Aventis Pharma Gmbh | Substituted beta-carbolines with lkB-kinase inhibiting activity |
EP1134221A1 (en) * | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines as lkB kinase inhibitors |
CZ2003106A3 (cs) * | 2000-07-13 | 2003-04-16 | Eli Lilly And Company | Agonisté adrenergního beta-3 receptoru |
US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
US6537994B2 (en) * | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
US6498170B2 (en) | 2000-07-17 | 2002-12-24 | Wyeth | Cyclamine sulfonamides as β-3 adrenergic receptor agonists |
ES2265447T3 (es) * | 2000-11-10 | 2007-02-16 | Eli Lilly And Company | Agonistas de receptor beta-3 de oxindol-3-sustituido. |
KR100408122B1 (ko) * | 2000-12-08 | 2003-12-01 | 한국디디에스제약 주식회사 | 광학 입체 이성질체의 성질을 갖는 베타 아드레날린 길항제의 제조 방법 |
DE60215028T2 (de) | 2001-08-14 | 2007-03-15 | Eli Lilly And Co., Indianapolis | Indol derivate als beta-3-adrenerge agonisten zur behandlung von typ 2 diabetes |
US6911463B2 (en) | 2001-08-14 | 2005-06-28 | Eli Lilly And Company | 3-substituted oxindole β-3 agonists |
EP1448561B1 (en) | 2001-11-20 | 2008-02-20 | Eli Lilly And Company | Beta 3 adrenergic agonists |
JP2005514366A (ja) | 2001-11-20 | 2005-05-19 | イーライ・リリー・アンド・カンパニー | 3−置換オキシインドールβ3アゴニスト |
JP2005520805A (ja) | 2002-01-11 | 2005-07-14 | イーライ・リリー・アンド・カンパニー | 2−オキソ−ベンズイミダゾリル置換型エタノールアミン誘導体およびβ3アゴニストとしてのその使用 |
PT1562595E (pt) * | 2002-09-19 | 2008-07-28 | Lilly Co Eli | Éteres diarílicos como antagonistas de receptor de opióides |
CN1756746A (zh) | 2003-03-07 | 2006-04-05 | 伊莱利利公司 | 作为阿片样物质受体拮抗剂的6-取代的烟酰胺衍生物 |
US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
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ES2394349B1 (es) | 2012-08-29 | 2013-11-04 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar |
KR20150046330A (ko) | 2012-10-02 | 2015-04-29 | 일라이 릴리 앤드 캄파니 | 닭 생산의 개선 방법 |
EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
DK3429603T3 (da) | 2016-03-15 | 2022-03-14 | Childrens Medical Center | Fremgangsmåder og sammensætninger vedrørende ekspansion af hæmatopoietiske stamceller |
US10865163B2 (en) | 2017-12-20 | 2020-12-15 | The University Of Toledo | Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds |
CN110668994A (zh) * | 2019-11-12 | 2020-01-10 | 山东创新药物研发有限公司 | 左旋卡维地洛盐晶型、其制备方法及应用 |
CN115611752A (zh) * | 2022-10-21 | 2023-01-17 | 江苏天和制药有限公司 | 一种卢巴贝隆中间体的合成精制方法 |
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-
1997
- 1997-08-27 AT AT97306613T patent/ATE215369T1/de not_active IP Right Cessation
- 1997-08-27 EP EP97306613A patent/EP0827746B1/en not_active Expired - Lifetime
- 1997-08-27 ES ES97306613T patent/ES2171839T3/es not_active Expired - Lifetime
- 1997-08-27 DE DE69711519T patent/DE69711519T2/de not_active Expired - Lifetime
- 1997-08-28 AU AU40941/97A patent/AU4094197A/en not_active Abandoned
- 1997-08-28 JP JP51275698A patent/JP4212117B2/ja not_active Expired - Fee Related
- 1997-08-28 WO PCT/US1997/015230 patent/WO1998009625A1/en active Application Filing
- 1997-08-28 US US09/068,192 patent/US6140352A/en not_active Expired - Lifetime
- 1997-09-02 PE PE1997000778A patent/PE109398A1/es not_active Application Discontinuation
- 1997-09-03 CO CO97051043A patent/CO4910132A1/es unknown
- 1997-09-03 AR ARP970104011A patent/AR009518A1/es unknown
- 1997-09-03 AR ARP970104012A patent/AR009519A1/es active IP Right Grant
- 1997-09-04 ID IDP973089A patent/ID17182A/id unknown
- 1997-09-04 MY MYPI97004098A patent/MY132626A/en unknown
-
2000
- 2000-06-30 US US09/610,096 patent/US6413991B1/en not_active Expired - Fee Related
-
2002
- 2002-04-10 US US10/120,302 patent/US6686372B2/en not_active Expired - Fee Related
-
2003
- 2003-10-27 US US10/694,467 patent/US7041684B2/en not_active Expired - Fee Related
Also Published As
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US6140352A (en) | 2000-10-31 |
ES2171839T3 (es) | 2002-09-16 |
MY132626A (en) | 2007-10-31 |
PE109398A1 (es) | 1999-01-15 |
EP0827746A1 (en) | 1998-03-11 |
AR009519A1 (es) | 2000-04-26 |
US7041684B2 (en) | 2006-05-09 |
DE69711519D1 (de) | 2002-05-08 |
EP0827746B1 (en) | 2002-04-03 |
AU4094197A (en) | 1998-03-26 |
ATE215369T1 (de) | 2002-04-15 |
DE69711519T2 (de) | 2002-10-31 |
WO1998009625A1 (en) | 1998-03-12 |
JP4212117B2 (ja) | 2009-01-21 |
US6413991B1 (en) | 2002-07-02 |
US20020165234A1 (en) | 2002-11-07 |
US6686372B2 (en) | 2004-02-03 |
JP2002513387A (ja) | 2002-05-08 |
ID17182A (id) | 1997-12-04 |
US20050043337A1 (en) | 2005-02-24 |
AR009518A1 (es) | 2000-04-26 |
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