CO4700519A1 - Derivados de la 4-mercapto - benzoilguanidina - Google Patents
Derivados de la 4-mercapto - benzoilguanidinaInfo
- Publication number
- CO4700519A1 CO4700519A1 CO96004146A CO96004146A CO4700519A1 CO 4700519 A1 CO4700519 A1 CO 4700519A1 CO 96004146 A CO96004146 A CO 96004146A CO 96004146 A CO96004146 A CO 96004146A CO 4700519 A1 CO4700519 A1 CO 4700519A1
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- benzoilguanidine
- mercapt
- derivatives
- nha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Testing Resistance To Weather, Investigating Materials By Mechanical Methods (AREA)
Abstract
4-Mercapto-benzoilguanidinas caracterizadas por la fórmula I:en la que R1 representa A, CF3 , CH2 F, CHF2 o C2 F5 , R2 representa H, A, cicloalquilo de 3 a 7 átomos de C, Ph o Het, Het representa un heterociclo de uno o dos núcleos, saturado, insaturado o aromático, con 1 a 4 átomos de N, O y/o S, a través del N o C, que puede estar no sustituido o sustituido una, dos o tres veces con Hal, CF3 , A, OH, OA, SH, SA, NH2 , NHA, NA2 , CN, NO2 y/o carboniloxi, A es alquilo de 1 a 6 átomos de C, Hal es F, Cl, Br o I y Ph representa fenilo no sustituido o sustituido una, dos o tres veces con A, OA, NH2 , NHA, NA2 , F, Cl, Br y/o CF3 , y sus sales aceptables desde el punto de vista fisiológico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19502895A DE19502895A1 (de) | 1995-01-31 | 1995-01-31 | 4-Mercapto-benzoylguanidin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4700519A1 true CO4700519A1 (es) | 1998-12-29 |
Family
ID=7752677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO96004146A CO4700519A1 (es) | 1995-01-31 | 1996-01-31 | Derivados de la 4-mercapto - benzoilguanidina |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5696167A (es) |
| EP (1) | EP0725062B1 (es) |
| JP (1) | JP3770947B2 (es) |
| CN (1) | CN1058001C (es) |
| AR (1) | AR002954A1 (es) |
| AT (1) | ATE202088T1 (es) |
| AU (1) | AU706843B2 (es) |
| BR (1) | BR9600263A (es) |
| CA (1) | CA2168319C (es) |
| CO (1) | CO4700519A1 (es) |
| CZ (1) | CZ290184B6 (es) |
| DE (2) | DE19502895A1 (es) |
| DK (1) | DK0725062T3 (es) |
| ES (1) | ES2159652T3 (es) |
| FI (1) | FI960423L (es) |
| GR (1) | GR3036344T3 (es) |
| HU (1) | HUP9600213A3 (es) |
| NO (1) | NO305834B1 (es) |
| PL (1) | PL181311B1 (es) |
| PT (1) | PT725062E (es) |
| RU (1) | RU2162079C2 (es) |
| SI (1) | SI0725062T1 (es) |
| SK (1) | SK281199B6 (es) |
| TR (1) | TR199600067A2 (es) |
| TW (1) | TW432036B (es) |
| UA (1) | UA43345C2 (es) |
| ZA (1) | ZA96701B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| KR20010080597A (ko) * | 1998-11-26 | 2001-08-22 | 플레믹 크리스티안 | 인슐린 비의존성 당뇨병 치료를 위한 벤조일구아니딘의 용도 |
| DE19859727A1 (de) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
| DE19951418A1 (de) * | 1999-10-26 | 2001-05-03 | Merck Patent Gmbh | Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid |
| AR061478A1 (es) | 2006-06-19 | 2008-08-27 | Takeda Pharmaceutical | Compuesto triciclico y composicion farmaceutica |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| ES2108144T3 (es) * | 1992-02-15 | 1997-12-16 | Hoechst Ag | Benzoilguanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. |
| DK0589336T3 (da) * | 1992-09-22 | 1997-06-16 | Hoechst Ag | Benzylguanidiner, fremgangsmåde til deres fremstilling samt deres anvendelse som antiarytmetika |
| TW250479B (es) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
| DE4318658A1 (de) * | 1993-06-04 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4318756A1 (de) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4328869A1 (de) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1995
- 1995-01-31 DE DE19502895A patent/DE19502895A1/de not_active Withdrawn
-
1996
- 1996-01-19 EP EP96100764A patent/EP0725062B1/de not_active Expired - Lifetime
- 1996-01-19 PT PT96100764T patent/PT725062E/pt unknown
- 1996-01-19 DK DK96100764T patent/DK0725062T3/da active
- 1996-01-19 ES ES96100764T patent/ES2159652T3/es not_active Expired - Lifetime
- 1996-01-19 DE DE59607055T patent/DE59607055D1/de not_active Expired - Lifetime
- 1996-01-19 SI SI9630327T patent/SI0725062T1/xx unknown
- 1996-01-19 AT AT96100764T patent/ATE202088T1/de not_active IP Right Cessation
- 1996-01-20 TW TW085100660A patent/TW432036B/zh active
- 1996-01-25 AU AU42200/96A patent/AU706843B2/en not_active Ceased
- 1996-01-26 TR TR96/00067A patent/TR199600067A2/xx unknown
- 1996-01-26 AR ARP960101167A patent/AR002954A1/es unknown
- 1996-01-29 CA CA002168319A patent/CA2168319C/en not_active Expired - Fee Related
- 1996-01-29 UA UA96010340A patent/UA43345C2/uk unknown
- 1996-01-29 SK SK128-96A patent/SK281199B6/sk unknown
- 1996-01-30 FI FI960423A patent/FI960423L/fi unknown
- 1996-01-30 US US08/593,863 patent/US5696167A/en not_active Expired - Lifetime
- 1996-01-30 NO NO960392A patent/NO305834B1/no unknown
- 1996-01-30 PL PL96312544A patent/PL181311B1/pl unknown
- 1996-01-30 CN CN96101110A patent/CN1058001C/zh not_active Expired - Fee Related
- 1996-01-30 ZA ZA96701A patent/ZA96701B/xx unknown
- 1996-01-30 BR BR9600263A patent/BR9600263A/pt not_active Application Discontinuation
- 1996-01-30 RU RU96101794/04A patent/RU2162079C2/ru not_active IP Right Cessation
- 1996-01-30 HU HU9600213A patent/HUP9600213A3/hu unknown
- 1996-01-30 CZ CZ1996277A patent/CZ290184B6/cs not_active IP Right Cessation
- 1996-01-31 JP JP03584896A patent/JP3770947B2/ja not_active Expired - Fee Related
- 1996-01-31 CO CO96004146A patent/CO4700519A1/es unknown
-
2001
- 2001-08-07 GR GR20010401196T patent/GR3036344T3/el not_active IP Right Cessation
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