CO4700428A1 - Derivados de la 4-amino-benzoilguanidina - Google Patents
Derivados de la 4-amino-benzoilguanidinaInfo
- Publication number
- CO4700428A1 CO4700428A1 CO96003094A CO96003094A CO4700428A1 CO 4700428 A1 CO4700428 A1 CO 4700428A1 CO 96003094 A CO96003094 A CO 96003094A CO 96003094 A CO96003094 A CO 96003094A CO 4700428 A1 CO4700428 A1 CO 4700428A1
- Authority
- CO
- Colombia
- Prior art keywords
- amino
- atoms
- nha
- hal
- substituted
- Prior art date
Links
- CNRCFIFMZGXXRA-UHFFFAOYSA-N 4-amino-n-(diaminomethylidene)benzamide Chemical class NC(=N)NC(=O)C1=CC=C(N)C=C1 CNRCFIFMZGXXRA-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
4-Amino-benzoilguanidinas caracterizadas por la fórmula Ien la queR1 representa A, CF3 , CH2 F, CHF2 , o C2 F5 ,R2 y R3 representan, independientemente uno delotro, respectivamente H, A, cicloalquilo de 3 a 7 átomos de C, Ph o Het,R2 y R3 juntos también representan alquileno de 4 a 5 átomos de C, Het representa un heterociclo de uno o dos núcleos, saturado, insaturado o aromático, con 1 a 4 átomos de N, O y/o S, unido a través del N o C, que puede estar no sustituido o sustituido una, dos o tres veces con Hal, CF3 , A, OH, OA, SH, SA, NH2 , NHA, NA2 , CN, NO2 y/o carbonilo-oxígeno, A es alquilo de 1 a 6 átomos de C, Hal es F, Cl, Br o I y Ph representa fenilo no sustituido o sustituido una, dos o tres veces con A, OA, NH2 , NHA, NA2 , F, Cl, Br y/o CF3 , y sus sales aceptables desde el punto de vista fisiológico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19502644A DE19502644A1 (de) | 1995-01-28 | 1995-01-28 | 4-Amino-benzoylguanidin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4700428A1 true CO4700428A1 (es) | 1998-12-29 |
Family
ID=7752517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO96003094A CO4700428A1 (es) | 1995-01-28 | 1996-01-25 | Derivados de la 4-amino-benzoilguanidina |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5739142A (es) |
| EP (1) | EP0723963B1 (es) |
| JP (1) | JP3770946B2 (es) |
| KR (1) | KR100521853B1 (es) |
| CN (1) | CN1057999C (es) |
| AR (1) | AR002273A1 (es) |
| AT (1) | ATE202093T1 (es) |
| AU (1) | AU705632B2 (es) |
| BR (1) | BR9600217A (es) |
| CA (1) | CA2168192C (es) |
| CO (1) | CO4700428A1 (es) |
| CZ (1) | CZ289922B6 (es) |
| DE (2) | DE19502644A1 (es) |
| DK (1) | DK0723963T3 (es) |
| ES (1) | ES2158153T3 (es) |
| FI (1) | FI960376L (es) |
| GR (1) | GR3036572T3 (es) |
| HU (1) | HUP9600173A3 (es) |
| NO (1) | NO305793B1 (es) |
| PL (1) | PL182219B1 (es) |
| PT (1) | PT723963E (es) |
| RU (1) | RU2160728C2 (es) |
| SI (1) | SI0723963T1 (es) |
| SK (1) | SK281198B6 (es) |
| TR (1) | TR199600064A2 (es) |
| TW (1) | TW325463B (es) |
| UA (1) | UA56983C2 (es) |
| ZA (1) | ZA96629B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19737463A1 (de) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden |
| KR20010042125A (ko) * | 1998-03-23 | 2001-05-25 | 오흘러 로스 제이. | 피페리디디닐 및 ｎ-아미디노피페리디닐 유도체 |
| KR20010080597A (ko) * | 1998-11-26 | 2001-08-22 | 플레믹 크리스티안 | 인슐린 비의존성 당뇨병 치료를 위한 벤조일구아니딘의 용도 |
| DE19859727A1 (de) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
| DE10023405A1 (de) * | 2000-05-12 | 2001-11-15 | Merck Patent Gmbh | Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen |
| SA04250283B1 (ar) * | 2003-09-26 | 2008-05-26 | سولفاي فارماسيتيكالز جي أم بي أتش | مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid |
| DE102005030400A1 (de) * | 2005-06-27 | 2006-12-28 | Archimica Gmbh | Verfahren zur Herstellung von Arylaminen, Arylethern und Arylthioethern |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| DK0589336T3 (da) * | 1992-09-22 | 1997-06-16 | Hoechst Ag | Benzylguanidiner, fremgangsmåde til deres fremstilling samt deres anvendelse som antiarytmetika |
| DE4328869A1 (de) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1995
- 1995-01-28 DE DE19502644A patent/DE19502644A1/de not_active Withdrawn
-
1996
- 1996-01-05 UA UA96010053A patent/UA56983C2/uk unknown
- 1996-01-19 SI SI9630328T patent/SI0723963T1/xx unknown
- 1996-01-19 PT PT96100763T patent/PT723963E/pt unknown
- 1996-01-19 DK DK96100763T patent/DK0723963T3/da active
- 1996-01-19 AT AT96100763T patent/ATE202093T1/de not_active IP Right Cessation
- 1996-01-19 DE DE59607054T patent/DE59607054D1/de not_active Expired - Lifetime
- 1996-01-19 EP EP96100763A patent/EP0723963B1/de not_active Expired - Lifetime
- 1996-01-19 ES ES96100763T patent/ES2158153T3/es not_active Expired - Lifetime
- 1996-01-22 AU AU42112/96A patent/AU705632B2/en not_active Ceased
- 1996-01-25 BR BR9600217A patent/BR9600217A/pt not_active Application Discontinuation
- 1996-01-25 CO CO96003094A patent/CO4700428A1/es unknown
- 1996-01-26 SK SK122-96A patent/SK281198B6/sk unknown
- 1996-01-26 JP JP03122196A patent/JP3770946B2/ja not_active Expired - Fee Related
- 1996-01-26 AR ARP960101165A patent/AR002273A1/es unknown
- 1996-01-26 CZ CZ1996252A patent/CZ289922B6/cs not_active IP Right Cessation
- 1996-01-26 US US08/592,660 patent/US5739142A/en not_active Expired - Lifetime
- 1996-01-26 CA CA002168192A patent/CA2168192C/en not_active Expired - Fee Related
- 1996-01-26 PL PL96312490A patent/PL182219B1/pl not_active IP Right Cessation
- 1996-01-26 FI FI960376A patent/FI960376L/fi unknown
- 1996-01-26 TR TR96/00064A patent/TR199600064A2/xx unknown
- 1996-01-26 TW TW085100970A patent/TW325463B/zh active
- 1996-01-26 CN CN96101244A patent/CN1057999C/zh not_active Expired - Fee Related
- 1996-01-26 RU RU96101810/04A patent/RU2160728C2/ru not_active IP Right Cessation
- 1996-01-26 NO NO960353A patent/NO305793B1/no not_active IP Right Cessation
- 1996-01-26 HU HU9600173A patent/HUP9600173A3/hu unknown
- 1996-01-26 ZA ZA96629A patent/ZA96629B/xx unknown
- 1996-01-27 KR KR1019960002014A patent/KR100521853B1/ko not_active Expired - Fee Related
-
2001
- 2001-09-10 GR GR20010401429T patent/GR3036572T3/el not_active IP Right Cessation
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