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CO4480024A1 - Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo - Google Patents

Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo

Info

Publication number
CO4480024A1
CO4480024A1 CO95046243A CO95046243A CO4480024A1 CO 4480024 A1 CO4480024 A1 CO 4480024A1 CO 95046243 A CO95046243 A CO 95046243A CO 95046243 A CO95046243 A CO 95046243A CO 4480024 A1 CO4480024 A1 CO 4480024A1
Authority
CO
Colombia
Prior art keywords
ltb4
antagonists
benzopyrans
benzo
new
Prior art date
Application number
CO95046243A
Other languages
English (en)
Inventor
Mark Anthony Dombroski
Kevin Koch
Anthony Daniel Piscopio
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO4480024A1 publication Critical patent/CO4480024A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVOS BENZOPIRANOS Y A OTROS ANTAGONISTAS DE B4(LTB4) LEUCOTRIENA FU- SIONADOS CON BENZO, A LAS SALES FARMACEUTICAMENTE ACEPTABLES DE TALES COMPUESTOS, A LAS COMPOSICIO- NES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS, Y AL PROCEDIMIENTO PARA USAR TALES COMPUESTOS COMO ANTAGONISTAS DE LTB4. LOS COMPUESTOS Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE ESTA INVENCION INHIBEN LA ACCION DEL LTB4 Y POR LO TANTO SON UTI- LES EN EL TRATAMIENTO DE ENFERMEDADES INDUCIDAS POR LTB4 TALES COMO TRASTORNOS INFLAMATORIOS IN- CLUIDA ARTRITIS REUMATOIDE, OSTEOARTRITIS, ENFER- MEDAD INFLAMATORIA DE LOS INTESTINOS, PSORIASIS, Y OTROS TRASTORNOS DE LA PIEL TALES COMO ECZEMA, ERITEMA, PRURITO, Y ACNE, GOLPE Y OTRAS FORMAS DE DANO DE PERFUSION, RECHAZO DE INJERTO, ENFERMEDA- DES AUTOINMUNES, ASMA, Y OTROS ESTADOS DONDE OCU- RRE LA INFILTRACION, NEUTROFILICA ACENTUADA. FIGURA 1
CO95046243A 1994-10-13 1995-10-04 Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo CO4480024A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32287694A 1994-10-13 1994-10-13

Publications (1)

Publication Number Publication Date
CO4480024A1 true CO4480024A1 (es) 1997-07-09

Family

ID=23256829

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95046243A CO4480024A1 (es) 1994-10-13 1995-10-04 Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo

Country Status (23)

Country Link
US (2) US6051601A (es)
EP (1) EP0785930A1 (es)
JP (1) JP2983295B2 (es)
KR (1) KR100232341B1 (es)
CN (1) CN1160399A (es)
AU (1) AU696890B2 (es)
BR (1) BR9504385A (es)
CA (1) CA2201742A1 (es)
CO (1) CO4480024A1 (es)
CZ (1) CZ111797A3 (es)
FI (1) FI971524A0 (es)
HU (1) HUT77515A (es)
IL (1) IL115529A0 (es)
MX (1) MX9702731A (es)
NO (1) NO971672L (es)
NZ (1) NZ285156A (es)
PE (1) PE10897A1 (es)
PL (1) PL319688A1 (es)
RU (1) RU2128655C1 (es)
TR (1) TR199501270A2 (es)
TW (1) TW304941B (es)
WO (1) WO1996011920A1 (es)
ZA (1) ZA958597B (es)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
ES2206738T3 (es) * 1996-09-16 2004-05-16 Pfizer Inc. Procedimientos e intermediarios para la preparacion de derivados sustituidos de cromanol.
US5817684A (en) * 1996-12-13 1998-10-06 Eli Lilly And Company Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke
IL128731A0 (en) * 1998-03-12 2000-01-31 Pfizer Prod Inc Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
MXPA03006876A (es) * 2001-01-30 2003-11-13 Pfizer Prod Inc Intermedios y procedimientos para preparar derivados de cromanol sustituido.
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
NZ536664A (en) 2002-06-19 2007-07-27 Biovitrum Ab Piperazinylpyrazine derivative compounds, their use and preparation
EP1773396A1 (en) * 2004-07-22 2007-04-18 Pharmacia Corporation Compositions for treatment of inflammation and pain using a combination of a cox-2 selective inhibitor and a ltb4 receptor antagonist
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
AU2005316739A1 (en) 2004-12-13 2006-06-22 Galileo Pharmaceuticals, Inc. Spiro derivatives as lipoxygenase inhibitors
CA2600004A1 (en) 2005-02-25 2006-09-08 Eli Lilly And Company Spiro-heterocyclic chromans, thiochromans and dihydroquinolines
US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
WO2007134149A2 (en) * 2006-05-11 2007-11-22 Janssen Pharmaceutica N.V. 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors
CA2651942A1 (en) 2006-05-11 2008-07-03 Janssen Pharmaceutica N.V. 1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors
MX2011002613A (es) 2008-09-11 2011-05-23 Pfizer Derivados de heteroarilamida y su uso como activadores de glucoquinasa.
NZ595024A (en) 2009-03-11 2013-01-25 Pfizer Benzofuranyl derivatives used as glucokinase inhibitors
US9453022B2 (en) 2012-02-14 2016-09-27 Children's Hospital Medical Center Use of small molecule inhibitors targeting the interaction between Rac GTPase and p67 (phox)
CN102920692A (zh) * 2012-10-25 2013-02-13 中国人民解放军第二军医大学 (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用
SG11201707418WA (en) 2015-03-13 2017-10-30 Forma Therapeutics Inc Alpha-cinnamide compounds and compositions as hdac8 inhibitors
WO2017040963A1 (en) 2015-09-03 2017-03-09 Forma Therapeutics, Inc. [6,6] fused bicyclic hdac8 inhibitors
EP3383389B1 (en) 2015-11-30 2021-04-28 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
US20190382363A1 (en) * 2015-11-30 2019-12-19 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
EP3383388B1 (en) 2015-11-30 2021-04-14 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
US10450309B2 (en) 2015-11-30 2019-10-22 Merch Sharp & Dohme Corp. Aryl sulfonamides as BLT1 antagonists
US20190216790A1 (en) * 2016-10-13 2019-07-18 The Regents Of The University Of California Methods for Treating Pruritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
US5073562A (en) * 1990-05-10 1991-12-17 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5051438A (en) * 1990-05-16 1991-09-24 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists
DK0623122T3 (da) * 1992-01-23 1997-04-21 Pfizer Benzopyran og beslægtede LTB4-antagonister
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.

Also Published As

Publication number Publication date
CZ111797A3 (cs) 1998-07-15
IL115529A0 (en) 1996-01-19
WO1996011920A1 (en) 1996-04-25
PE10897A1 (es) 1997-04-21
KR100232341B1 (ko) 2000-07-01
MX9702731A (es) 1997-06-28
CN1160399A (zh) 1997-09-24
NZ285156A (en) 1999-01-28
JP2983295B2 (ja) 1999-11-29
TR199501270A2 (tr) 1996-06-21
TW304941B (es) 1997-05-11
AU2416795A (en) 1996-05-06
CA2201742A1 (en) 1996-04-25
FI971524A (fi) 1997-04-11
JPH09512035A (ja) 1997-12-02
KR970706270A (ko) 1997-11-03
BR9504385A (pt) 1997-05-27
NO971672L (no) 1997-06-11
US6133286A (en) 2000-10-17
HUT77515A (hu) 1998-05-28
AU696890B2 (en) 1998-09-24
RU2128655C1 (ru) 1999-04-10
FI971524A0 (fi) 1997-04-11
ZA958597B (en) 1997-04-14
US6051601A (en) 2000-04-18
NO971672D0 (no) 1997-04-11
PL319688A1 (en) 1997-08-18
EP0785930A1 (en) 1997-07-30

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