[go: up one dir, main page]

FI971524A0 - Bentsopyraani- ja bentsofuusioituneita yhdisteitä, niiden valmistus ja niiden käyttö leukotrieeni-B4(LTB4)-antagonisteina - Google Patents

Bentsopyraani- ja bentsofuusioituneita yhdisteitä, niiden valmistus ja niiden käyttö leukotrieeni-B4(LTB4)-antagonisteina

Info

Publication number
FI971524A0
FI971524A0 FI971524A FI971524A FI971524A0 FI 971524 A0 FI971524 A0 FI 971524A0 FI 971524 A FI971524 A FI 971524A FI 971524 A FI971524 A FI 971524A FI 971524 A0 FI971524 A0 FI 971524A0
Authority
FI
Finland
Prior art keywords
ltb4
benzopyran
leukotriene
antagonists
preparation
Prior art date
Application number
FI971524A
Other languages
English (en)
Swedish (sv)
Other versions
FI971524A (fi
Inventor
Mark A Dombroski
Kevin Koch
Anthony D Piscopio
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI971524A0 publication Critical patent/FI971524A0/fi
Publication of FI971524A publication Critical patent/FI971524A/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
FI971524A 1994-10-13 1997-04-11 Bentsopyraani- ja bentsofuusioituneita yhdisteitä, niiden valmistus ja niiden käyttö leukotrieeni-B4(LTB4)-antagonisteina FI971524A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32287694A 1994-10-13 1994-10-13
PCT/IB1995/000401 WO1996011920A1 (en) 1994-10-13 1995-05-26 Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4 (ltb4) antagonists

Publications (2)

Publication Number Publication Date
FI971524A0 true FI971524A0 (fi) 1997-04-11
FI971524A FI971524A (fi) 1997-04-11

Family

ID=23256829

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971524A FI971524A (fi) 1994-10-13 1997-04-11 Bentsopyraani- ja bentsofuusioituneita yhdisteitä, niiden valmistus ja niiden käyttö leukotrieeni-B4(LTB4)-antagonisteina

Country Status (23)

Country Link
US (2) US6051601A (fi)
EP (1) EP0785930A1 (fi)
JP (1) JP2983295B2 (fi)
KR (1) KR100232341B1 (fi)
CN (1) CN1160399A (fi)
AU (1) AU696890B2 (fi)
BR (1) BR9504385A (fi)
CA (1) CA2201742A1 (fi)
CO (1) CO4480024A1 (fi)
CZ (1) CZ111797A3 (fi)
FI (1) FI971524A (fi)
HU (1) HUT77515A (fi)
IL (1) IL115529A0 (fi)
MX (1) MX9702731A (fi)
NO (1) NO971672L (fi)
NZ (1) NZ285156A (fi)
PE (1) PE10897A1 (fi)
PL (1) PL319688A1 (fi)
RU (1) RU2128655C1 (fi)
TR (1) TR199501270A2 (fi)
TW (1) TW304941B (fi)
WO (1) WO1996011920A1 (fi)
ZA (1) ZA958597B (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA58520C2 (uk) * 1996-09-16 2003-08-15 Пфайзер, Інк. Спосіб та проміжні сполуки для одержання похідних заміщеного хроманолу
EP0961617A4 (en) * 1996-12-13 2002-08-07 Lilly Co Eli LEUKOTRINE ANTAGONISTS FOR TREATING FOCAL BRAIN CHEMISTRY
IL128731A0 (en) * 1998-03-12 2000-01-31 Pfizer Prod Inc Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
CA2433516A1 (en) * 2001-01-30 2002-08-08 Keith Michael Devries Processes for preparing chromanylbenzoic acids
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
IL165220A0 (en) 2002-06-19 2005-12-18 Biovitrum Ab Novel compounds, their use and preparation
AU2005266088A1 (en) * 2004-07-22 2006-02-02 Pharmacia Corporation Compositions for treatment of inflammation and pain using a combination of a COX-2 selective inhibitor and a LTB4 receptor antagonist
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
MX2007007103A (es) * 2004-12-13 2008-03-10 Lilly Co Eli Derivados espiro como inhibidores de lipoxigenasa.
WO2006093548A1 (en) 2005-02-25 2006-09-08 Galileo Pharmaceuticals, Inc. Spiro-heterocyclic chromans, thiochromans and dihydroquinolines
US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
CA2651942A1 (en) 2006-05-11 2008-07-03 Janssen Pharmaceutica N.V. 1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors
WO2007134149A2 (en) 2006-05-11 2007-11-22 Janssen Pharmaceutica N.V. 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors
GEP20135793B (en) 2008-09-11 2013-03-25 Pfizer Heteroaryls amide derivatives and their use as glucokinase activators
PT2406253E (pt) * 2009-03-11 2013-09-11 Pfizer Derivados de benzofuranilo utilizados como inibidores de glucocinase
WO2013123081A2 (en) * 2012-02-14 2013-08-22 Children's Hospital Medical Center Use of small molecule inhibitors targeting the interaction between rac gtpase and p67 (phox)
CN102920692A (zh) * 2012-10-25 2013-02-13 中国人民解放军第二军医大学 (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用
CR20170420A (es) 2015-03-13 2017-10-03 Forma Therapeutics Inc Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8
TW201711999A (zh) 2015-09-03 2017-04-01 佛瑪治療公司 ﹝6,6﹞稠合雙環組蛋白脫乙醯基酶8(hdac8)抑制劑
US10450309B2 (en) 2015-11-30 2019-10-22 Merch Sharp & Dohme Corp. Aryl sulfonamides as BLT1 antagonists
US10336733B2 (en) 2015-11-30 2019-07-02 Merk Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
WO2017095724A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
EP3383389B1 (en) 2015-11-30 2021-04-28 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
US20190216790A1 (en) * 2016-10-13 2019-07-18 The Regents Of The University Of California Methods for Treating Pruritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
US5073562A (en) * 1990-05-10 1991-12-17 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5051438A (en) * 1990-05-16 1991-09-24 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists
EP0623122B1 (en) * 1992-01-23 1997-03-05 Pfizer Inc. Benzopyran and related LTB4-antagonists.
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.

Also Published As

Publication number Publication date
CA2201742A1 (en) 1996-04-25
US6051601A (en) 2000-04-18
EP0785930A1 (en) 1997-07-30
PL319688A1 (en) 1997-08-18
ZA958597B (en) 1997-04-14
KR970706270A (ko) 1997-11-03
MX9702731A (es) 1997-06-28
KR100232341B1 (ko) 2000-07-01
WO1996011920A1 (en) 1996-04-25
JPH09512035A (ja) 1997-12-02
PE10897A1 (es) 1997-04-21
AU2416795A (en) 1996-05-06
RU2128655C1 (ru) 1999-04-10
CN1160399A (zh) 1997-09-24
CO4480024A1 (es) 1997-07-09
TW304941B (fi) 1997-05-11
HUT77515A (hu) 1998-05-28
CZ111797A3 (cs) 1998-07-15
NO971672D0 (no) 1997-04-11
NO971672L (no) 1997-06-11
NZ285156A (en) 1999-01-28
BR9504385A (pt) 1997-05-27
JP2983295B2 (ja) 1999-11-29
TR199501270A2 (tr) 1996-06-21
IL115529A0 (en) 1996-01-19
AU696890B2 (en) 1998-09-24
US6133286A (en) 2000-10-17
FI971524A (fi) 1997-04-11

Similar Documents

Publication Publication Date Title
FI971524A0 (fi) Bentsopyraani- ja bentsofuusioituneita yhdisteitä, niiden valmistus ja niiden käyttö leukotrieeni-B4(LTB4)-antagonisteina
FI971523A (fi) Bentsopyraani- ja bentsofuusioituja yhdisteitä, niiden valmistus ja käyttö leukotrieeni B4':n (LTB4) antagonisteina
FI955235A0 (fi) Oksatsolidiinionijohdannaiset, niiden valmistus ja käyttö
BR9711970A (pt) Derivados 6,5-substitu¡do-heterobic¡clicos
EE9900147A (et) Oksadiasoolid, nende saamismeetodid ja kasutamine ravimitena
DE59501802D1 (de) Substituierte 1H-3-Aryl-pyrrolidin-2,4-dion-Derivate
EE200000621A (et) Pikornaviirusevastased ühendid, nende valmistamine ja kasutamine
EE200000468A (et) Ühendid, nende kasutamine ja farmatseutiline kompositsioon
AU6325899A (en) New compounds, their preparation and use
EE200000037A (et) Atsüülpiperasinüülpürimidiinide derivaadid, nende valmistamine ja kasutamine ravimitena
EE04721B1 (et) Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
FI943473A0 (fi) Bentsopyraani ja senkaltaiset LTB4-antagonistit
DK1437359T3 (da) Hidtil ukendte 3,6-hemiketaler fra 9a-azalidklassen
FI943474A (fi) Bentsopyraani ja senkaltaiset LTB4-antagonistit
IT1292461B1 (it) Composti fotocromatici,procedimento per la loro preparazione e loro utilizzo in materiali polimerici
ATE212346T1 (de) 3-substituierte tetrahydropyridopyrimidinon- derivate, ihre herstellung und verwendung
AU2652395A (en) Leukotriene b4 antagonists
DE59501950D1 (de) Isolongifolanol-Derivate, ihre Herstellung und ihre Verwendung
ATE249451T1 (de) Benzofuranderivate, ihre herstellung und verwendung
FI935654A (fi) Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö
FI971317A0 (fi) Uusia heterosyklisiä, substituoituja imidatsolokinoksalinoneja, niiden valmistus ja käyttö
DK0804088T3 (da) Stabiliseret sammensætning, der omfatter solisinsulfat
IT1278010B1 (it) Ftalocianine d'alluminio, loro preparazione e loro impiego come coloranti.
BR9509295A (pt) Escareador
TR199501046A1 (tr) Sübstitüe bifeniller.