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CO2022007172A2 - Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar - Google Patents

Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar

Info

Publication number
CO2022007172A2
CO2022007172A2 CONC2022/0007172A CO2022007172A CO2022007172A2 CO 2022007172 A2 CO2022007172 A2 CO 2022007172A2 CO 2022007172 A CO2022007172 A CO 2022007172A CO 2022007172 A2 CO2022007172 A2 CO 2022007172A2
Authority
CO
Colombia
Prior art keywords
bile acid
compounds
benzothi
acid modulators
diseases
Prior art date
Application number
CONC2022/0007172A
Other languages
English (en)
Inventor
Ingemar Starke
Santosh S Kulkarni
Per-Göran Gillberg
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2020/084567 external-priority patent/WO2021110883A1/en
Application filed by Albireo Ab filed Critical Albireo Ab
Publication of CO2022007172A2 publication Critical patent/CO2022007172A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La invención se refiere a los derivados 1,5-benzotiazepina y 1,2,5-benzotiadiazepina de la fórmula (I). Estos compuestos son moduladores del ácido biliar que tienen el transportador apical del ácido biliar dependiente del sodio (ASBT) y/o actividad inhibidora del transporte del ácido biliar del hígado (LBAT). La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y al uso de estos compuestos en el tratamiento de enfermedades cardiovasculares, metabolismo de ácidos grasos y trastornos debidos al uso de la glucosa, enfermedades gastrointestinales y enfermedades hepáticas.
CONC2022/0007172A 2019-12-04 2022-05-26 Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar CO2022007172A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201911049982 2019-12-04
PCT/EP2020/084567 WO2021110883A1 (en) 2019-12-04 2020-12-04 Benzothia(di)azepine compounds and their use as bile acid modulators

Publications (1)

Publication Number Publication Date
CO2022007172A2 true CO2022007172A2 (es) 2022-06-10

Family

ID=76209525

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0007172A CO2022007172A2 (es) 2019-12-04 2022-05-26 Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar

Country Status (19)

Country Link
US (3) US11180465B2 (es)
EP (1) EP4069360B1 (es)
JP (1) JP7695242B2 (es)
KR (1) KR20220109450A (es)
CN (1) CN114761079B (es)
AU (1) AU2020397448A1 (es)
BR (1) BR112022010505A2 (es)
CA (1) CA3158195A1 (es)
CO (1) CO2022007172A2 (es)
CR (1) CR20220315A (es)
DK (1) DK4069360T3 (es)
ES (1) ES2973549T3 (es)
FI (1) FI4069360T3 (es)
IL (1) IL293379A (es)
MX (1) MX2022006731A (es)
PE (1) PE20230234A1 (es)
PH (1) PH12022551085A1 (es)
PL (1) PL4069360T3 (es)
SA (1) SA522432741B1 (es)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
PL2637668T3 (pl) 2010-11-04 2017-01-31 Albireo Ab Inhibitory ibat do leczenia chorób wątroby
US10709755B2 (en) 2014-06-25 2020-07-14 Elobix Ab Solid formulation and method for preventing or reducing coloration thereof
WO2019234077A1 (en) 2018-06-05 2019-12-12 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
BR112020024479A2 (pt) 2018-06-20 2021-03-02 Albireo Ab hidrato cristalino, modificações cristalinas de odevixibat, solvato misto de odevixibat, uso de modificação cristalina de odevixibat, processo para a preparação de modificação cristalina de odevixibat, e, composição farmacêutica
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
RS63899B1 (sr) 2019-02-06 2023-02-28 Albireo Ab Benzotiadiazepinska jedinjenja i njihova upotreba kao modulatora žučnih kiselina
MX2022006731A (es) 2019-12-04 2022-06-09 Albireo Ab Compuestos de benzoti(di)azepina y su uso como moduladores del acido biliar.
EP4069247B1 (en) 2019-12-04 2025-03-26 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
CA3158276A1 (en) 2019-12-04 2021-06-10 Per-Goran Gillberg Benzothia(di)azepine compounds and their use as bile acid modulators
CN114761080B (zh) * 2019-12-04 2024-07-23 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
JP2023537285A (ja) 2020-08-03 2023-08-31 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
JP2023549226A (ja) 2020-11-12 2023-11-22 アルビレオ エービー 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
CA3198216A1 (en) * 2020-12-04 2022-06-09 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
KR20250022025A (ko) 2022-06-09 2025-02-14 알비레오 에이비 간염 치료
KR20250065681A (ko) * 2022-09-14 2025-05-13 미룸 파마슈티컬스, 인크. 마랄릭시바트 고체 형태, 중간체 및 그를 제조하는 방법
TW202500157A (zh) * 2023-05-25 2025-01-01 大陸商正大天晴藥業集團股份有限公司 一種苯並噻二氮卓化合物及其用途

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