CO2021007453A2 - Conjugados de insulina - Google Patents
Conjugados de insulinaInfo
- Publication number
- CO2021007453A2 CO2021007453A2 CONC2021/0007453A CO2021007453A CO2021007453A2 CO 2021007453 A2 CO2021007453 A2 CO 2021007453A2 CO 2021007453 A CO2021007453 A CO 2021007453A CO 2021007453 A2 CO2021007453 A2 CO 2021007453A2
- Authority
- CO
- Colombia
- Prior art keywords
- insulin
- mutation
- present
- relates
- insulin analog
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a un conjugado que comprende una sulfonamida de fórmula (I) y un ingrediente farmacéutico activo tal como un análogo de insulina que comprende por lo menos una mutación relativa a la insulina original, en donde el análogo de insulina comprende una mutación en la posición B16 que está sustituida con un aminoácido hidrófobo y/o una mutación en la posición B25 que está sustituida con un aminoácido hidrófobo. La presente invención se refiere además a una sulfonamida de fórmula (A). Asimismo, la presente invención se refiere a un análogo de insulina que comprende por lo menos una mutación relativa a la insulina original.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306657 | 2018-12-11 | ||
| EP18306658 | 2018-12-11 | ||
| EP18306659 | 2018-12-11 | ||
| PCT/EP2019/084400 WO2020120463A1 (en) | 2018-12-11 | 2019-12-10 | Insulin conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2021007453A2 true CO2021007453A2 (es) | 2021-06-21 |
Family
ID=68806785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2021/0007453A CO2021007453A2 (es) | 2018-12-11 | 2021-06-08 | Conjugados de insulina |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11098102B2 (es) |
| EP (3) | EP3894435A1 (es) |
| JP (3) | JP2022513775A (es) |
| KR (3) | KR20210102345A (es) |
| CN (3) | CN113395982A (es) |
| AU (3) | AU2019398579A1 (es) |
| BR (3) | BR112021011156A2 (es) |
| CA (3) | CA3122632A1 (es) |
| CO (1) | CO2021007453A2 (es) |
| IL (3) | IL283800A (es) |
| MX (3) | MX2021006969A (es) |
| PH (1) | PH12021551339A1 (es) |
| SG (3) | SG11202106166TA (es) |
| TW (3) | TW202039437A (es) |
| WO (3) | WO2020120479A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210102345A (ko) | 2018-12-11 | 2021-08-19 | 사노피 | 펩티드 결합제 |
| CN112876388B (zh) * | 2021-01-14 | 2023-03-31 | 山东大学 | 一种gpr120激动剂及其制备方法与应用 |
| CN116162147B (zh) * | 2021-11-24 | 2023-10-03 | 成都奥达生物科技有限公司 | 一种长效胰岛素类似物 |
| CN114230451A (zh) * | 2021-12-29 | 2022-03-25 | 上海药坦药物研究开发有限公司 | 卤代酸类化合物的制备方法 |
| JP2025508329A (ja) * | 2022-01-26 | 2025-03-26 | サノフイ | インスリンコンジュゲート |
| TW202417519A (zh) | 2022-06-23 | 2024-05-01 | 法商賽諾菲公司 | 單鏈胰島素及其Fc接合物 |
| CN115947822B (zh) * | 2022-07-04 | 2023-08-18 | 北京惠之衡生物科技有限公司 | 一种长效酰化胰岛素衍生物及其药物组合物和应用 |
| WO2024051787A1 (zh) * | 2022-09-09 | 2024-03-14 | 北京惠之衡生物科技有限公司 | 一种长效酰化胰岛素衍生物及其应用 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ273285A (en) | 1993-09-17 | 1997-10-24 | Novo Nordisk As | Insulin derivatives and compositions thereof |
| KR19980703039A (ko) | 1995-03-17 | 1998-09-05 | 켈스버그 라아스 | 인슐린 유도체 |
| US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| PE123799A1 (es) | 1997-10-24 | 1999-12-13 | Lilly Co Eli | Composiciones insolubles de insulina |
| BRPI0512988A (pt) | 2004-07-08 | 2008-04-22 | Novo Nordisk As | método para aumentar a meia-vida plasmática de uma molécula, composto, uso do mesmo, e, composição farmacêutica |
| ES2428510T3 (es) | 2005-02-02 | 2013-11-08 | Novo Nordisk A/S | Derivados de insulina |
| ES2435522T3 (es) | 2005-02-02 | 2013-12-20 | Novo Nordisk A/S | Derivados de insulina |
| EP1917363B1 (en) | 2005-08-16 | 2011-06-22 | Novo Nordisk A/S | Method for making mature insulin polypeptides |
| ATE557037T1 (de) | 2006-02-27 | 2012-05-15 | Novo Nordisk As | Insulin derivate |
| WO2007104736A2 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
| EP2024390B1 (en) | 2006-05-09 | 2015-08-19 | Novo Nordisk A/S | Insulin derivative |
| MX2008014061A (es) | 2006-05-09 | 2008-11-14 | Novo Nordisk As | Derivado de insulina. |
| US20090306337A1 (en) | 2006-07-31 | 2009-12-10 | Novo Nordisk A/S | Pegylated, Extended Insulins |
| WO2008034881A1 (en) | 2006-09-22 | 2008-03-27 | Novo Nordisk A/S | Protease resistant insulin analogues |
| WO2008049711A1 (en) | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
| GB0621973D0 (en) | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
| EP1974729A1 (en) * | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
| WO2009010428A1 (en) | 2007-07-16 | 2009-01-22 | Novo Nordisk A/S | Protease stabilized, pegylated insulin analogues |
| WO2009022013A1 (en) | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
| JP5721432B2 (ja) | 2007-08-15 | 2015-05-20 | ノボ・ノルデイスク・エー／エス | アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン |
| NZ603812A (en) | 2007-11-20 | 2014-06-27 | Ambrx Inc | Modified insulin polypeptides and their uses |
| WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| PT2254906T (pt) | 2008-03-18 | 2017-01-03 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
| ES2563553T3 (es) | 2008-04-01 | 2016-03-15 | Novo Nordisk A/S | Conjugados de insulina-albúmina |
| PL219335B1 (pl) * | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| BRPI0919946A2 (pt) | 2008-10-30 | 2016-02-16 | Novo Nordisk As | tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente |
| EP2376531A1 (en) | 2008-12-09 | 2011-10-19 | Novo Nordisk A/S | Novel insulin analogues |
| WO2010080609A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| EP2376520B1 (en) | 2008-12-19 | 2014-02-12 | Indiana University Research&Technology Corporation | Insulin analogs |
| WO2010130638A1 (en) * | 2009-05-14 | 2010-11-18 | Evotec Ag | Sulfonamide compounds, pharmaceutical compositions and uses thereof |
| CA2797133C (en) * | 2010-04-27 | 2019-08-06 | Zealand Pharma A/S | Peptide conjugates of glp-1 receptor agonists and gastrin and their use |
| WO2011141407A1 (en) | 2010-05-10 | 2011-11-17 | Novo Nordisk A/S | Process for the preparation of insulin-zinc complexes |
| US8946147B2 (en) | 2010-06-24 | 2015-02-03 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| JP2013540771A (ja) | 2010-10-15 | 2013-11-07 | ノヴォ ノルディスク アー／エス | 新規ｎ末端修飾インスリン誘導体 |
| TWI574687B (zh) * | 2011-01-03 | 2017-03-21 | 古利斯股份有限公司 | 具有鋅結合部份之刺蝟拮抗劑 |
| CN103596584B (zh) | 2011-06-15 | 2016-12-14 | 诺沃—诺迪斯克有限公司 | 多取代的胰岛素 |
| WO2013086786A1 (zh) | 2011-12-15 | 2013-06-20 | Qin Shulin | 具有降血糖作用的化合物、组合物及其用途 |
| CN104788556A (zh) | 2011-12-15 | 2015-07-22 | 上海恒瑞医药有限公司 | 人胰岛素类似物及其酰化衍生物 |
| CN104364262A (zh) | 2011-12-21 | 2015-02-18 | 诺沃—诺迪斯克有限公司 | N末端修饰的胰岛素衍生物 |
| US20150111820A1 (en) | 2012-07-09 | 2015-04-23 | Novo Nordisk A/S | Novel use of insulin derivatives |
| CN105008395B (zh) | 2012-11-05 | 2020-12-29 | 卡斯西部储备大学 | 长效单链胰岛素类似物 |
| EP3616727B1 (en) | 2013-02-26 | 2021-03-31 | Hanmi Pharm. Co., Ltd. | Insulin analog conjugates and use thereof |
| CA2904332A1 (en) * | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| JP6755175B2 (ja) | 2013-03-20 | 2020-09-16 | ノヴォ ノルディスク アー／エス | インスリン投薬レジメン |
| JP2016519127A (ja) | 2013-04-30 | 2016-06-30 | ノヴォ ノルディスク アー／エス | 新規投与レジメン |
| WO2014195452A1 (en) | 2013-06-07 | 2014-12-11 | Novo Nordisk A/S | Method for making mature insulin polypeptides |
| JP6347451B2 (ja) * | 2013-08-02 | 2018-06-27 | 国立大学法人富山大学 | （ベンゼンスルホニルアミノ）ベンズアミド誘導体およびそれらを有効成分とするｓｈｉｐ２阻害剤 |
| PL3086815T3 (pl) | 2013-12-27 | 2022-06-13 | Zymeworks Inc. | Układy łącznikowe dla koniugatów leków zawierające ugrupowanie sulfonamidowe |
| US10253082B2 (en) | 2014-01-20 | 2019-04-09 | Hanmi Pharm. Co., Ltd | Long-acting insulin and use thereof |
| AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| AR100639A1 (es) * | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
| KR20160001391A (ko) | 2014-06-27 | 2016-01-06 | 한미약품 주식회사 | 신규한 지속형 인슐린 아날로그 결합체 및 이의 용도 |
| WO2016001185A1 (en) | 2014-07-02 | 2016-01-07 | Novo Nordisk A/S | Dosage regimen for the treatment of diabetes |
| KR20160007295A (ko) | 2014-07-11 | 2016-01-20 | 한미약품 주식회사 | 인슐린 아날로그 |
| US20180000742A1 (en) | 2015-01-29 | 2018-01-04 | Novo Nordisk A/S | Pharmaceutical Composition for Oral Insulin Administration Comprising a Tablet Core and a Polyvinyl Alcohol Coating |
| WO2016172269A2 (en) | 2015-04-20 | 2016-10-27 | University Of Utah Research Foundation | Insulin analogs having shortened b chain peptides and associated methods |
| JP2018531899A (ja) | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー／エス | 新規インスリン誘導体及びその医学的使用 |
| EP3341401A1 (en) | 2015-08-25 | 2018-07-04 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| DK3341044T3 (da) | 2015-08-25 | 2020-02-17 | Novo Nordisk As | Medicinsk injektionsindretning med et rensningskammer |
| PL239062B1 (pl) | 2016-01-22 | 2021-11-02 | Inst Biotechnologii I Antybiotykow | Sposób wytwarzania insuliny i jej pochodnych |
| WO2018024186A1 (zh) | 2016-08-02 | 2018-02-08 | 江苏恒瑞医药股份有限公司 | 一种人胰岛素或其类似物的酰化衍生物 |
| EP3517544B1 (en) | 2016-09-23 | 2025-01-08 | Hanmi Pharm. Co., Ltd. | Insulin analog having reduced binding force to insulin receptor, and use thereof |
| TW201831504A (zh) | 2016-11-21 | 2018-09-01 | 美國凱斯西方瑞瑟夫大學 | 增強穩定性之速效胰島素類似物 |
| US11359001B2 (en) * | 2016-12-09 | 2022-06-14 | Akston Biosciences Corporation | Insulin-Fc fusions and methods of use |
| CN110087674B (zh) | 2016-12-16 | 2023-01-03 | 诺和诺德股份有限公司 | 含胰岛素的药物组合物 |
| CA3052410A1 (en) | 2017-02-03 | 2018-08-09 | Hanmi Pharm. Co., Ltd. | Conjugate of bioactive material having enhanced sustainability and use thereof |
| JP7604098B2 (ja) | 2017-03-23 | 2024-12-23 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリン受容体との結合力が減少されたインスリンアナログの結合体及びその用途 |
| JOP20190273A1 (ar) | 2017-05-26 | 2019-11-24 | Lilly Co Eli | مركب إنسولين معالج بأسيل |
| KR20190036956A (ko) | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | 지속형 단쇄 인슐린 아날로그 및 이의 결합체 |
| JP2021014409A (ja) * | 2017-11-21 | 2021-02-12 | 京都薬品工業株式会社 | タンパク質結合性薬物 |
| US11413352B2 (en) | 2017-12-18 | 2022-08-16 | Merck, Sharp & Dohme LLC | Conjugate based systems for controlled insulin delivery |
| KR20210102345A (ko) | 2018-12-11 | 2021-08-19 | 사노피 | 펩티드 결합제 |
| BR112022011291A2 (pt) | 2019-12-10 | 2022-09-06 | Sanofi Sa | Método para formar um conjugado de uma sulfonamida e um polipeptídeo |
-
2019
- 2019-12-10 KR KR1020217021394A patent/KR20210102345A/ko not_active Withdrawn
- 2019-12-10 WO PCT/EP2019/084433 patent/WO2020120479A1/en active Application Filing
- 2019-12-10 MX MX2021006969A patent/MX2021006969A/es unknown
- 2019-12-10 US US16/709,208 patent/US11098102B2/en active Active
- 2019-12-10 TW TW108145065A patent/TW202039437A/zh unknown
- 2019-12-10 JP JP2021533148A patent/JP2022513775A/ja active Pending
- 2019-12-10 AU AU2019398579A patent/AU2019398579A1/en active Pending
- 2019-12-10 WO PCT/EP2019/084400 patent/WO2020120463A1/en active Application Filing
- 2019-12-10 KR KR1020217021396A patent/KR20210102347A/ko active Pending
- 2019-12-10 EP EP19816341.2A patent/EP3894435A1/en active Pending
- 2019-12-10 TW TW108145066A patent/TW202039539A/zh unknown
- 2019-12-10 CA CA3122632A patent/CA3122632A1/en active Pending
- 2019-12-10 CA CA3122636A patent/CA3122636A1/en active Pending
- 2019-12-10 SG SG11202106166TA patent/SG11202106166TA/en unknown
- 2019-12-10 BR BR112021011156-5A patent/BR112021011156A2/pt unknown
- 2019-12-10 CN CN201980091301.0A patent/CN113395982A/zh active Pending
- 2019-12-10 CN CN201980091275.1A patent/CN113396157A/zh active Pending
- 2019-12-10 MX MX2021006970A patent/MX2021006970A/es unknown
- 2019-12-10 SG SG11202106168VA patent/SG11202106168VA/en unknown
- 2019-12-10 CA CA3122637A patent/CA3122637A1/en active Pending
- 2019-12-10 WO PCT/EP2019/084427 patent/WO2020120477A1/en unknown
- 2019-12-10 EP EP19816338.8A patent/EP3893934A1/en active Pending
- 2019-12-10 BR BR112021011050-0A patent/BR112021011050A2/pt unknown
- 2019-12-10 TW TW108145067A patent/TW202039438A/zh unknown
- 2019-12-10 AU AU2019398658A patent/AU2019398658A1/en active Pending
- 2019-12-10 SG SG11202106167XA patent/SG11202106167XA/en unknown
- 2019-12-10 MX MX2021006972A patent/MX2021006972A/es unknown
- 2019-12-10 JP JP2021533153A patent/JP2022511567A/ja active Pending
- 2019-12-10 CN CN201980091302.5A patent/CN113423691A/zh active Pending
- 2019-12-10 EP EP19816708.2A patent/EP3894391A1/en active Pending
- 2019-12-10 JP JP2021533149A patent/JP2022513776A/ja active Pending
- 2019-12-10 AU AU2019398402A patent/AU2019398402A1/en active Pending
- 2019-12-10 KR KR1020217021395A patent/KR20210102346A/ko not_active Ceased
- 2019-12-10 BR BR112021011099-2A patent/BR112021011099A2/pt unknown
-
2021
- 2021-05-25 US US17/329,558 patent/US12195510B2/en active Active
- 2021-06-07 PH PH12021551339A patent/PH12021551339A1/en unknown
- 2021-06-08 CO CONC2021/0007453A patent/CO2021007453A2/es unknown
- 2021-06-08 IL IL283800A patent/IL283800A/en unknown
- 2021-06-08 IL IL283801A patent/IL283801A/en unknown
- 2021-06-08 IL IL283803A patent/IL283803A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2021007453A2 (es) | Conjugados de insulina | |
| CO2019009680A2 (es) | Anticuerpo anti-gprc5d y molécula que comprende el anticuerpo | |
| BR112018072467A2 (pt) | composições farmacêuticas com permeação aumentada | |
| DOP2019000117A (es) | Nuevos derivados de quinolina | |
| MX2019014104A (es) | Compuesto novedoso de bifenilo o sal del mismo. | |
| DOP2020000023A (es) | Nuevos derivados de quinolina | |
| MX375570B (es) | Conjugados de pirrolobenzodiazepina | |
| UY37789A (es) | Nuevos derivados de azaquinolina | |
| CU20150096A7 (es) | Compuestos de amida y composición farmacéutica para el tratamiento de vih | |
| CO2020001242A2 (es) | Dihidrooxadiazinonas | |
| BR112016008736A2 (pt) | formulação estável de insulina glulisina | |
| BR112021016198A2 (pt) | Formulações de anticorpo anti-il-36r | |
| MX2019014445A (es) | Preparacion hidratante topica. | |
| MX2017010623A (es) | Derivados de quinoleina para usarse en el tratamiento o prevencion de una infeccion viral. | |
| MX2020003495A (es) | Derivados de acido boronico y sintesis de los mismos. | |
| ZA202006377B (en) | Boronic acid derivatives and therapeutic uses thereof | |
| MX2018004304A (es) | DERIVADOS DE QUINOXALINA Y PIRIDOPRAZINA COMO INHIBIDORES DE PI3Kß. | |
| BR112016001876A2 (pt) | composto de benzoxaborol tricíclico, método de preparação e uso do mesmo | |
| CO2022010011A2 (es) | Derivado de amino arilo novedoso útil como inhibidor de diacilglicerol aciltransferasa 2 y uso del mismo | |
| BR112017026904A2 (pt) | formulações farmacêuticas injetáveis de lefamulina | |
| BR112023001471A2 (pt) | Composição farmacêutica de anticorpo anti-pd-1 e uso da mesma | |
| BR112022012971A2 (pt) | Misturas inseticidas | |
| MX394833B (es) | Formulaciones con mejora de la estabilidad. | |
| CO2022009260A2 (es) | Composiciones farmacéuticas oftálmicas | |
| CO2018008626A2 (es) | Formulaciones de oritavancina |