SG11202106167XA - Insulin conjugates - Google Patents

Insulin conjugates

Info

Publication number: SG11202106167XA
Authority: SG; Singapore
Prior art keywords: insulin conjugates; conjugates; insulin
Prior art date: 2018-12-11

Application number

SG11202106167XA

Inventor

Perez Maria Mendez

Nils Rackelmann

Laurent Bialy

Stefan Guessregen

Martin Will

Thomas Boehme

Garea Ana Villar

Marcus Hermann Korn

Melissa Besenius

Jens Riedel

Ulrich Werner

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-12-11

Filing date

2019-12-10

Publication date

2021-07-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=68806785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11202106167X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2019-12-10 Application filed by Sanofi Sa filed Critical Sanofi Sa

2021-07-29 Publication of SG11202106167XA publication Critical patent/SG11202106167XA/en

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SG11202106167XA 2018-12-11 2019-12-10 Insulin conjugates SG11202106167XA (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP18306658		2018-12-11
EP18306657		2018-12-11
EP18306659		2018-12-11
PCT/EP2019/084400 WO2020120463A1 (en)	2018-12-11	2019-12-10	Insulin conjugates

Publications (1)

Publication Number	Publication Date
SG11202106167XA true SG11202106167XA (en)	2021-07-29

Family

ID=68806785

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SG11202106167XA SG11202106167XA (en)	2018-12-11	2019-12-10	Insulin conjugates
SG11202106166TA SG11202106166TA (en)	2018-12-11	2019-12-10	Peptide binder
SG11202106168VA SG11202106168VA (en)	2018-12-11	2019-12-10	Insulin analogs having reduced insulin receptor binding affinity

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
SG11202106166TA SG11202106166TA (en)	2018-12-11	2019-12-10	Peptide binder
SG11202106168VA SG11202106168VA (en)	2018-12-11	2019-12-10	Insulin analogs having reduced insulin receptor binding affinity

Country Status (15)

Country	Link
US (3)	US11098102B2 (en)
EP (3)	EP3894391A1 (en)
JP (3)	JP2022513775A (en)
KR (3)	KR20210102347A (en)
CN (3)	CN113423691A (en)
AU (3)	AU2019398579A1 (en)
BR (3)	BR112021011156A2 (en)
CA (3)	CA3122637A1 (en)
CO (1)	CO2021007453A2 (en)
IL (3)	IL283800A (en)
MX (3)	MX2021006972A (en)
PH (1)	PH12021551339A1 (en)
SG (3)	SG11202106167XA (en)
TW (3)	TW202039437A (en)
WO (3)	WO2020120479A1 (en)

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CN115947822B (en) *	2022-07-04	2023-08-18	北京惠之衡生物科技有限公司	Long-acting acylated insulin derivative, and pharmaceutical composition and application thereof
WO2024051787A1 (en) *	2022-09-09	2024-03-14	北京惠之衡生物科技有限公司	Long-acting acylated insulin derivative and use thereof

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2019
- 2019-12-10 KR KR1020217021396A patent/KR20210102347A/en not_active Ceased
- 2019-12-10 CA CA3122637A patent/CA3122637A1/en active Pending
- 2019-12-10 BR BR112021011156-5A patent/BR112021011156A2/en unknown
- 2019-12-10 EP EP19816708.2A patent/EP3894391A1/en active Pending
- 2019-12-10 WO PCT/EP2019/084433 patent/WO2020120479A1/en active Application Filing
- 2019-12-10 WO PCT/EP2019/084400 patent/WO2020120463A1/en not_active Application Discontinuation
- 2019-12-10 SG SG11202106167XA patent/SG11202106167XA/en unknown
- 2019-12-10 TW TW108145065A patent/TW202039437A/en unknown
- 2019-12-10 CN CN201980091302.5A patent/CN113423691A/en active Pending
- 2019-12-10 JP JP2021533148A patent/JP2022513775A/en active Pending
- 2019-12-10 EP EP19816338.8A patent/EP3893934A1/en active Pending
- 2019-12-10 CA CA3122632A patent/CA3122632A1/en active Pending
- 2019-12-10 JP JP2021533153A patent/JP2022511567A/en active Pending
- 2019-12-10 WO PCT/EP2019/084427 patent/WO2020120477A1/en unknown
- 2019-12-10 BR BR112021011099-2A patent/BR112021011099A2/en unknown
- 2019-12-10 SG SG11202106166TA patent/SG11202106166TA/en unknown
- 2019-12-10 KR KR1020217021394A patent/KR20210102345A/en not_active Withdrawn
- 2019-12-10 TW TW108145066A patent/TW202039539A/en unknown
- 2019-12-10 JP JP2021533149A patent/JP2022513776A/en active Pending
- 2019-12-10 AU AU2019398579A patent/AU2019398579A1/en not_active Abandoned
- 2019-12-10 EP EP19816341.2A patent/EP3894435A1/en active Pending
- 2019-12-10 AU AU2019398402A patent/AU2019398402A1/en not_active Abandoned
- 2019-12-10 MX MX2021006972A patent/MX2021006972A/en unknown
- 2019-12-10 KR KR1020217021395A patent/KR20210102346A/en not_active Ceased
- 2019-12-10 MX MX2021006969A patent/MX2021006969A/en unknown
- 2019-12-10 TW TW108145067A patent/TW202039438A/en unknown
- 2019-12-10 US US16/709,208 patent/US11098102B2/en active Active
- 2019-12-10 CN CN201980091301.0A patent/CN113395982A/en active Pending
- 2019-12-10 AU AU2019398658A patent/AU2019398658A1/en not_active Abandoned
- 2019-12-10 CN CN201980091275.1A patent/CN113396157A/en active Pending
- 2019-12-10 BR BR112021011050-0A patent/BR112021011050A2/en unknown
- 2019-12-10 SG SG11202106168VA patent/SG11202106168VA/en unknown
- 2019-12-10 MX MX2021006970A patent/MX2021006970A/en unknown
- 2019-12-10 CA CA3122636A patent/CA3122636A1/en active Pending
2021
- 2021-05-25 US US17/329,558 patent/US12195510B2/en active Active
- 2021-06-07 PH PH12021551339A patent/PH12021551339A1/en unknown
- 2021-06-08 CO CONC2021/0007453A patent/CO2021007453A2/en unknown
- 2021-06-08 IL IL283800A patent/IL283800A/en unknown
- 2021-06-08 IL IL283803A patent/IL283803A/en unknown
- 2021-06-08 IL IL283801A patent/IL283801A/en unknown
2024
- 2024-12-05 US US18/970,367 patent/US20250206798A1/en active Pending

Also Published As

Publication number	Publication date
KR20210102346A (en)	2021-08-19
US12195510B2 (en)	2025-01-14
WO2020120479A1 (en)	2020-06-18
CA3122637A1 (en)	2020-06-18
CN113395982A (en)	2021-09-14
AU2019398579A1 (en)	2021-07-29
US20250206798A1 (en)	2025-06-26
US11098102B2 (en)	2021-08-24
MX2021006972A (en)	2021-08-16
CN113423691A (en)	2021-09-21
JP2022513775A (en)	2022-02-09
CO2021007453A2 (en)	2021-06-21
IL283800A (en)	2021-07-29
WO2020120463A1 (en)	2020-06-18
CA3122632A1 (en)	2020-06-18
WO2020120477A1 (en)	2020-06-18
IL283801A (en)	2021-07-29
KR20210102345A (en)	2021-08-19
SG11202106168VA (en)	2021-07-29
AU2019398658A1 (en)	2021-07-29
EP3893934A1 (en)	2021-10-20
KR20210102347A (en)	2021-08-19
JP2022513776A (en)	2022-02-09
US20220048968A1 (en)	2022-02-17
BR112021011099A2 (en)	2021-10-26
PH12021551339A1 (en)	2021-11-29
EP3894435A1 (en)	2021-10-20
BR112021011156A2 (en)	2021-10-26
BR112021011050A2 (en)	2021-08-31
TW202039539A (en)	2020-11-01
IL283803A (en)	2021-07-29
TW202039438A (en)	2020-11-01
JP2022511567A (en)	2022-01-31
MX2021006970A (en)	2021-07-15
CA3122636A1 (en)	2020-06-18
CN113396157A (en)	2021-09-14
US20200181223A1 (en)	2020-06-11
EP3894391A1 (en)	2021-10-20
TW202039437A (en)	2020-11-01
AU2019398402A1 (en)	2021-07-29
SG11202106166TA (en)	2021-07-29
MX2021006969A (en)	2021-07-15

Publication	Publication Date	Title
IL278990A (en)	2021-01-31	Camptothecin conjugates
ZA201904269B (en)	2022-12-21	Pyrrolobenzodiazepine-antibody conjugates
SI3592393T1 (en)	2022-04-29	Releasable conjugates
IL267834B1 (en)	2023-09-01	Anti-ccr7 antibody drug conjugates
PT3544636T (en)	2021-05-04	Pyrrolobenzodiazepine-antibody conjugates
IL283801A (en)	2021-07-29	Insulin conjugates
IL277572A (en)	2020-11-30	Il-2 conjugates
GB201702031D0 (en)	2017-03-22	Pyrrolobenzodiazepine-antibody conjugates
CA187784S (en)	2020-07-21	Syringe
EP3280450A4 (en)	2018-12-12	Glucose-responsive insulin conjugates
IL289892A (en)	2022-03-01	Infusion unit
GB201820626D0 (en)	2019-01-30	Conjugates
SG10201907154QA (en)	2020-04-29	Cannula
IL288681A (en)	2022-02-01	Pyrrolobenzodiazepine-antibody conjugates
GB2585141B (en)	2022-01-12	Syringe
GB201906997D0 (en)	2019-07-03	Conjugates
HK40061691A (en)	2022-06-02	Insulin conjugates
GB201811332D0 (en)	2018-08-29	Pyrroloobenzodiazepine-antibody conjugates
GB201811335D0 (en)	2018-08-29	Pyrrolobenzodiazepine-antibody conjugates
GB201900735D0 (en)	2019-03-06	Conjugates
GB201910995D0 (en)	2019-09-18	DepthSet syringe
GB201721290D0 (en)	2018-01-31	Conjugates
GB201719906D0 (en)	2018-01-17	Pyrrolobenzodiazepine-antibody conjugates
GB201719391D0 (en)	2018-01-03	Pyrrolobenzodiazepine-antibody conjugates
GB201719398D0 (en)	2018-01-03	Pyrrolobenzodiazepine-antibody conjugates