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CO2017011152A2 - Nuevos compuestos bicíclicos como inhibidores duales de atx / ca. - Google Patents

Nuevos compuestos bicíclicos como inhibidores duales de atx / ca.

Info

Publication number
CO2017011152A2
CO2017011152A2 CONC2017/0011152A CO2017011152A CO2017011152A2 CO 2017011152 A2 CO2017011152 A2 CO 2017011152A2 CO 2017011152 A CO2017011152 A CO 2017011152A CO 2017011152 A2 CO2017011152 A2 CO 2017011152A2
Authority
CO
Colombia
Prior art keywords
inhibitors
bicyclic compounds
new bicyclic
compounds
atx
Prior art date
Application number
CONC2017/0011152A
Other languages
English (en)
Inventor
Daniel Hunziker
Jérôme Hert
Patrizio Mattei
Markus Rudolph
Petra Schmitz
Christoph Ullmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO2017011152A2 publication Critical patent/CO2017011152A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención proporciona nuevos compuestos que tienen la fórmula general (I), en la que R1, R2, R9, Y, W, m, n, p y q tienen los significados aquí definidos, composiciones que contienen dichos compuestos y métodos de uso de tales compuestos.
CONC2017/0011152A 2015-09-24 2017-10-30 Nuevos compuestos bicíclicos como inhibidores duales de atx / ca. CO2017011152A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186642 2015-09-24
PCT/EP2016/072277 WO2017050747A1 (en) 2015-09-24 2016-09-20 New bicyclic compounds as dual atx/ca inhibitors

Publications (1)

Publication Number Publication Date
CO2017011152A2 true CO2017011152A2 (es) 2018-03-28

Family

ID=54199040

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0011152A CO2017011152A2 (es) 2015-09-24 2017-10-30 Nuevos compuestos bicíclicos como inhibidores duales de atx / ca.

Country Status (20)

Country Link
US (2) US10738053B2 (es)
EP (1) EP3353181B1 (es)
JP (1) JP6845230B2 (es)
KR (1) KR20180053408A (es)
CN (1) CN107614505B (es)
AR (1) AR106100A1 (es)
AU (1) AU2016328365B2 (es)
BR (1) BR112017026682A2 (es)
CA (1) CA2984585A1 (es)
CL (1) CL2018000649A1 (es)
CO (1) CO2017011152A2 (es)
CR (1) CR20180143A (es)
HK (1) HK1246788A1 (es)
IL (1) IL255511B (es)
MX (1) MX2017015034A (es)
PE (1) PE20180233A1 (es)
PH (1) PH12018500409A1 (es)
RU (1) RU2725138C2 (es)
TW (1) TW201725206A (es)
WO (1) WO2017050747A1 (es)

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JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
JP6846414B2 (ja) 2015-09-24 2021-03-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
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RU2724899C2 (ru) 2015-09-24 2020-06-26 Ф. Хоффманн-Ля Рош Аг Новые бициклические соединения в качестве дуальных ингибиторов atx/ca
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