CN87104199A - Preparation method of children's quick-acting cold spirit - Google Patents
Preparation method of children's quick-acting cold spirit Download PDFInfo
- Publication number
- CN87104199A CN87104199A CN198787104199A CN87104199A CN87104199A CN 87104199 A CN87104199 A CN 87104199A CN 198787104199 A CN198787104199 A CN 198787104199A CN 87104199 A CN87104199 A CN 87104199A CN 87104199 A CN87104199 A CN 87104199A
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- CN
- China
- Prior art keywords
- children
- quick
- powder
- acting
- percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 23
- 239000003814 drug Substances 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 9
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960005489 paracetamol Drugs 0.000 claims abstract description 8
- 206010004542 Bezoar Diseases 0.000 claims abstract description 5
- 239000008187 granular material Substances 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000007779 soft material Substances 0.000 claims description 6
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 235000020374 simple syrup Nutrition 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 239000004531 microgranule Substances 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 abstract 1
- 229960003291 chlorphenamine Drugs 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229940126673 western medicines Drugs 0.000 description 4
- 239000006187 pill Substances 0.000 description 3
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 241000282817 Bovidae Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000004641 brain development Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
一种小儿速效感冒灵的制作方法，属于含有机有效成分的医药配制品类。目前适用于治疗小儿感冒的药物极少。本发明提供了一种用扑热息痛粉、扑尔敏粉、牛黄等原料制作微型颗粒剂小儿速效感冒灵的方法。采用本方法制成的小儿速效感冒灵具有服用方便、疗效显著、见效迅速、无副作用的特点。The invention discloses a preparation method of quick-acting cold spirit for children, which belongs to the category of pharmaceutical preparations containing organic active ingredients. There are very few medicines currently applicable to the treatment of colds in children. The invention provides a method for preparing micro-granule children's quick-acting Ganmaoling by using paracetamol powder, chlorpheniramine powder, bezoar and other raw materials. The quick-acting Ganmaoling for children prepared by the method has the characteristics of convenient administration, remarkable curative effect, quick effect and no side effect.
Description
The preparation method of quick-acting cold-curing medicine for children belongs to the field of medicine preparation containing organic effective component.
The common cold and fever are common diseases and frequently encountered diseases of children. At present, western medicines for treating cold, such as paracetamol tablets, quick-acting cold capsules and the like, have good antipyretic and analgesic effects, but because caffeine is contained in the western medicines, the western medicines have great influence on the development of the brain of children, and are not suitable for being taken by the children. The Chinese patent medicines such as antelope wing antidotal pill (tablet) and the like are also common medicines for treating cold and fever, and although the pill has no side effect, the pill is difficult to take by children due to large dose and peculiar smell.
The invention aims to provide a method for preparing a quick-acting cold curing medicine for children. The quick-acting medicine for treating cold for children prepared by the method has obvious curative effect. Quick effect, convenient administration, and no adverse side effect.
The invention is prepared by taking the mixture of paracetamol powder, chlorphenamine maleate powder and bezoar powder as a main material, starch as an auxiliary material and the mixture of starch, powdered sugar and simple syrup as an adhesive. The preparation process is as follows: mixing paracetamol powder 37.5%, chlorphenamine maleate powder 0.5%, calculus bovis 2.5% and starch 9.5%. Preparing raw materials, adding 50% of adhesive to prepare soft materials. The binder is a pasty mixture prepared from 60% starch, 15% sugar powder, 25% simple syrup, ethanol and water. And (3) preparing the soft material into wet granules by using a granulator, adding a small amount of raw powder, rolling the granules, and drying the granules at the temperature of 55-65 ℃ for 30-50 minutes to prepare the micro granules.
The invention takes paracetamol powder as a main raw material, and keeps the advantage of quick curative effect of western medicines. The traditional Chinese medicine such as bezoar is added to achieve the effects of high curative effect and long curative effect. Contains no caffeine, has no side effect on infantile brain development, and is safe and reliable. The micro granules prepared by the method are easy to dissolve, easy to take and easy to absorb.
The best embodiment of the invention is as follows: the preparation method comprises the steps of grinding 7500 g of paracetamol powder, 100 g of chlorphenamine maleate powder, 450 g of calculus bovis factitius and 1950 g of starch by using a ball mill until the particle size reaches 160 meshes, uniformly mixing the powder to obtain raw powder, mixing 6000 g of starch, 1500 g of powdered sugar and 2500 g of simple syrup by using ethanol and water to obtain a paste adhesive, mixing the raw powder and the adhesive to obtain a soft material, preparing the soft material into wet granules by using a granulator, using a 30-36-mesh sieve during granulation, rolling the raw powder into the wet granules, drying the wet granules at 50 ℃ for 30 minutes to obtain dry granules, and screening to obtain a 20 kg micro granule finished product.
Claims (3)
1. A method for preparing quick-acting cold remedy for children belongs to the medicine preparation containing organic effective components, and the medicine preparation comprises paracetamol powder, chlorphenamine maleate powder, bezoar and the like, and is characterized in that: 37.5 percent of paracetamol powder, 0.5 percent of chlorphenamine maleate powder, 2.5 percent of bezoar powder and 9.5 percent of starch are prepared into raw powder, 50 percent of adhesive is added to prepare soft materials, and the soft materials are granulated and dried to prepare the micro-granules.
2. The method for preparing the children's quick-acting Ganmaoling as claimed in claim 1, wherein: the binder is a paste mixture of 60% starch, 15% sugar powder, 25% simple syrup, ethanol and water.
3. The method for preparing the children's quick-acting Ganmaoling as claimed in claim 1, wherein: the drying temperature is 55-65 ℃, and the drying time is 30-50 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN198787104199A CN87104199A (en) | 1987-06-11 | 1987-06-11 | Preparation method of children's quick-acting cold spirit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN198787104199A CN87104199A (en) | 1987-06-11 | 1987-06-11 | Preparation method of children's quick-acting cold spirit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN87104199A true CN87104199A (en) | 1988-01-06 |
Family
ID=4814772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN198787104199A Pending CN87104199A (en) | 1987-06-11 | 1987-06-11 | Preparation method of children's quick-acting cold spirit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN87104199A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1041992C (en) * | 1992-01-16 | 1999-02-10 | 沈阳中药厂 | Preparation technology of cold resistant panacla tablet |
| CN113057950A (en) * | 2020-01-02 | 2021-07-02 | 上海信谊万象药业股份有限公司 | Oral pediatric paracetamol, atificial cow-bezoar and chlorphenamine maleate granule preparation and preparation process thereof |
-
1987
- 1987-06-11 CN CN198787104199A patent/CN87104199A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1041992C (en) * | 1992-01-16 | 1999-02-10 | 沈阳中药厂 | Preparation technology of cold resistant panacla tablet |
| CN113057950A (en) * | 2020-01-02 | 2021-07-02 | 上海信谊万象药业股份有限公司 | Oral pediatric paracetamol, atificial cow-bezoar and chlorphenamine maleate granule preparation and preparation process thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |