CN104398657A - Preparation method of calyx seu fructus physalis dispersing tablet - Google Patents

Abstract

The invention discloses a preparation method of Jindenglong dispersible tablets with hypoglycemic effect. The dispersible tablet is made from the extract obtained by extracting and purifying Jindenglong, the diluent is lactose, microcrystalline cellulose, calcium sulfate, and the disintegrating agent is cross-linked polyvinylpyrrolidone, sodium carboxymethyl starch, low-substituted Hydroxypropyl cellulose, the lubricant is micro powdered silica gel, the flavoring agent is steviol glycoside, the binder is made of 5-10% polyvinylpyrrolidone K30 ethanol solution or 95% ethanol, and the dispersible tablet disintegrates completely within 3 minutes And reach a uniformly dispersed state, the dispersible tablet has the characteristics of fast disintegration and dissolution speed, high bioavailability, and relatively simple preparation process, and is suitable for industrialized large-scale production.

Description

A kind of preparation method of Jindenglan dispersible tablet

technical field

The invention relates to the technical field of medicine, in particular to a preparation method of Jindenglong dispersible tablets.

Background technique

Jindeng is the dry persistent calyx or the persistent calyx with fruit of Physalis Physalis of Solanaceae plant, which is a commonly used Chinese medicinal material included in the Pharmacopoeia of the People's Republic of China. Brocade lanterns have the effects of clearing heat and detoxification, relieving pharynx and phlegm, and diuresis. It is used to treat sore throat, hoarseness, phlegm-heat cough, dysuria, etc. It is also used for external treatment of pemphigus and eczema. It is commonly used by folks to treat acute and chronic bronchitis and Pharyngitis and diabetes etc. The chemical composition of brocade lanterns is complex, mainly containing steroids, flavonoids, alkaloids, amino acids, mineral elements and vitamins. In addition, it also contains zeaxanthin, resin, pectin, tannin, mucus, polysaccharide, organic acid and coumarin. Brocade lanterns have many pharmacological effects, such as: antibacterial effect, hypoglycemic effect, cardiotonic effect, excitatory effect of uterus, diuretic effect, anticancer effect. In addition, brocade lanterns also have pharmacological effects such as anti-inflammatory, contraceptive, immune function regulation, antipyretic and analgesic effects.

At present, the development speed of brocade lanterns is still relatively slow, and the research content is not comprehensive, which greatly restricts the wide application and development of brocade lanterns. Brocade lanterns are rich in resources and can be harvested every year. The raw materials are easy to get, cheap, and contain A variety of rich active ingredients, if brocade lanterns can be made into extracts with high active ingredients, and then the extracts can be made into dispersible tablets, which can make full use of natural resources, improve its economic benefits and promote the construction of Beiyao base in Jilin Province has far-reaching significance.

Dispersible tablets can be taken orally or dispersed in water and taken as a solution. They have the advantages of convenient oral administration, short disintegration time, uniform dispersion, rapid drug dissolution, fast absorption, high bioavailability, and small adverse reactions. It is especially convenient for children and the elderly who have difficulty swallowing. The present invention studies and designs a traditional Chinese medicine dispersible tablet with the extract of brocade lanterns as the main active ingredient, which can be conveniently applied to the prevention and treatment of patients with hyperglycemia.

Contents of the invention

The object of the present invention is to provide a preparation method of brocade lantern dispersible tablets. The dispersible tablet is made from the extract obtained by extracting Jindenglong, the diluent is lactose, microcrystalline cellulose, calcium sulfate, and the disintegrating agent is cross-linked polyvinylpyrrolidone, sodium carboxymethyl starch, low-substituted hydroxypropyl base cellulose, the lubricant is micropowder silica gel, the flavoring agent is steviol glycoside, and the binder is made of 5-10% polyvinylpyrrolidone K30 ethanol solution or 95% ethanol. The dispersible tablet disintegrates completely within 3 minutes and Evenly dispersed, the dispersible tablet has the characteristics of fast disintegration and dissolution, high bioavailability, and relatively simple preparation process, and is suitable for industrialized large-scale production.

The brocade lantern dispersible tablet of the present invention, the dispersible tablet is based on 1000 tablets, raw material brocade lantern 2000g, diluent microcrystalline cellulose 100-150g, lactose 50-100g, disintegrant cross-linked polyvinylpyrrolidone 30-60g , 5-20g of fine powdered silica gel as lubricant, 1.5-3.0g of steviol glycoside as flavoring agent, and 50-200mL of 5-10% polyvinylpyrrolidone ethanol solution as binder.

Brocade lantern dispersible tablet according to the present invention, the dispersible tablet is based on 1000 tablets, raw material brocade lantern 2000g, diluent microcrystalline cellulose 100-150g, calcium sulfate 50-100g, disintegrant cross-linked sodium carboxymethyl starch 20-40g, low-substituted hydroxypropyl cellulose 10-40g, lubricant micro-powder silica gel 3-10g, flavoring agent steviol glycoside 1.5-3.0g, binder 50-200mL of 5-10% polyvinylpyrrolidone ethanol solution become.

Brocade lantern dispersible tablet according to the present invention, the dispersible tablet is based on 1000 tablets, raw material brocade lantern 2000g, diluent microcrystalline cellulose 100-150g, calcium sulfate 50-100g, disintegrant cross-linked sodium carboxymethyl starch 20-40g, 10-40g of low-substituted hydroxypropyl cellulose, 5-20g of micro-powdered silica gel as a lubricant, 1.5-3.0g of steviol glycoside as a flavoring agent, and 50-200mL of 95% ethanol solution as a binder.

The brocade lantern dispersible tablet of the present invention, the dispersible tablet is based on 1000 tablets, raw material brocade lantern 2000g, diluent microcrystalline cellulose 100-150g, lactose 50-100g, disintegrant cross-linked polyvinylpyrrolidone 30-60g , 3-10g of micro-powdered silica gel as lubricant, 1.5-3.0g of steviol glycoside as flavoring agent, and 50-200mL of 95% ethanol solution as the adhesive.

The preparation method of described brocade lantern dispersible tablet, carry out according to the following steps:

a. Preparation process of traditional Chinese medicine: Take 2000g of brocade lanterns, add 8 times the amount of 80% ethanol to reflux and extract twice, each time for 3 hours, filter, the filtrate is set aside, combine the filtrate, recover ethanol, concentrate to a relative density of 1.14-1.20 ( 60℃) clear ointment, add distilled water to disperse to a concentration of 0.25-0.35 g/mL (equivalent to the original drug), adjust the pH value of the liquid to 10, after the D-101 macroporous adsorption resin adsorption time of 30 minutes, the adsorption rate 1-2 BV/h, eluted with 3 BV distilled water after adsorption, then eluted with 3-5 BV of 70% ethanol at a flow rate of 1-2 BV/h, collected the eluate, concentrated, and dried in vacuum paste, the above-mentioned dry paste is crushed into fine powder;

b. The raw material Jindenglong dry extract, diluent microcrystalline cellulose, calcium sulfate, lactose, disintegrant cross-linked polyvinylpyrrolidone, cross-linked carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, lubricant micropowder silica gel , the flavoring agent steviol glycoside, and the binder polyvinylpyrrolidone are pulverized, passed through a 80-100 mesh sieve, and set aside;

c. According to the prescription quantity per 1000 tablets as the base, take the raw material Jindenglong dry extract of step b, diluent microcrystalline cellulose 125-150g, calcium sulfate 60-80g or microcrystalline cellulose 125-150g, lactose 60-80g Or microcrystalline cellulose 100-125g, calcium sulfate 50-60g, lactose 50-60g, disintegrant cross-linked carboxymethyl starch sodium 15g, low-substituted hydroxypropyl cellulose 10g or cross-linked polyvinylpyrrolidone 20g or cross-linked polyvinylpyrrolidone Vinylpyrrolidone 10g, cross-linked carboxymethyl starch sodium 10g, low-substituted hydroxypropyl cellulose 5g, flavoring agent steviol glycoside 2g, mix in a mixer, add binder 10% polyvinylpyrrolidone ethanol solution or 95% ethanol 160mL, use a high-speed granulator or a oscillating granulator for soft materials, use a 24-mesh sieve to granulate the soft materials, and dry the wet granules at 60°C;

d. After the wet granules are dried, use a 24-mesh sieve to size the granules, add 15g of disintegrant cross-linked carboxymethyl starch sodium, 10g of low-substituted hydroxypropyl cellulose or 30g of cross-linked polyvinylpyrrolidone or 10g of cross-linked polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, Dicarboxymethyl starch sodium 10g, low-substituted hydroxypropyl cellulose 5g, lubricant micropowder silica gel 3-5g, mix well, and compress into tablets to obtain brocade lantern dispersible tablets.

The Jindenglong dispersible tablet of the present invention contains an effective therapeutic dose of Jindenglong dry extract and a pharmaceutical carrier suitable for preparing a dispersible tablet, and the pharmaceutical carrier is selected from: diluent lactose, microcrystalline cellulose, calcium sulfate , disintegrant cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, lubricant micropowder silica gel, flavoring agent steviol glycoside, binder is 5-10% ethanol solution of polyvinylpyrrolidone or 95% ethanol.

The Jindenglong dispersible tablet of the present invention complies with the relevant provisions of the Chinese Pharmacopoeia 2010 edition on dispersible tablets: the dispersible tablet disintegrates completely within 3 minutes and reaches a uniformly dispersed state.

The present invention is further described below in conjunction with examples, but the scope of protection of the present invention is not limited to the following embodiments.

Example 1

a. Preparation process of traditional Chinese medicine: Take 2000g of brocade lanterns, add 8 times the amount of 80% ethanol to reflux and extract twice, each time for 3 hours, filter, the filtrate is set aside, combine the filtrate, recover ethanol, concentrate to a relative density of 1.14-1.20 ( 60℃) clear ointment, add distilled water to disperse to a concentration of 0.25-0.35 g/mL (equivalent to the original drug), adjust the pH value of the liquid to 10, after the D-101 macroporous adsorption resin adsorption time of 30 minutes, the adsorption rate 1-2 BV/h, eluted with 3 BV distilled water after adsorption, then eluted with 3-5 BV of 70% ethanol at a flow rate of 1-2 BV/h, collected the eluate, concentrated, and dried in vacuum paste, the above-mentioned dry paste is crushed into fine powder;

b. Grind the raw material Jindenglong dry extract, diluent microcrystalline cellulose, lactose, disintegrant cross-linked polyvinylpyrrolidone, lubricant micropowder silica gel, flavoring agent steviol glycoside, binder polyvinylpyrrolidone, and pass 80- 100 mesh sieve, spare;

c. According to the prescription quantity per 1000 tablets as the base, take the raw material Jindenglong dry extract of step b, diluent microcrystalline cellulose 125-150g, lactose 60-80g, disintegrant cross-linked polyvinylpyrrolidone 20g, flavoring agent Mix 2 g of steviol glycosides in a mixer, add 160 mL of ethanol solution of 10% polyvinylpyrrolidone as a binder, use a high-speed granulator or a swinging granulator to make soft materials, use a 24-mesh sieve to granulate the soft materials, and wet the granules at 60 Drying at ℃;

d. After the wet granules are dried, use a 24-mesh sieve to sieve the granules, add 30g of disintegrating agent cross-linked polyvinylpyrrolidone, and 3-5g of lubricant micropowder silica gel, mix well, and press into tablets to obtain brocade lantern dispersible tablets.

Example 2

a. Preparation process of traditional Chinese medicine: Take 2000g of brocade lanterns, add 8 times the amount of 80% ethanol to reflux and extract twice, each time for 3 hours, filter, the filtrate is set aside, combine the filtrate, recover ethanol, concentrate to a relative density of 1.14-1.20 ( 60℃) clear ointment, add distilled water to disperse to a concentration of 0.25-0.35 g/mL (equivalent to the original drug), adjust the pH value of the liquid to 10, after the D-101 macroporous adsorption resin adsorption time of 30 minutes, the adsorption rate 1-2 BV/h, eluted with 3 BV distilled water after adsorption, then eluted with 3-5 BV of 70% ethanol at a flow rate of 1-2 BV/h, collected the eluate, concentrated, and dried in vacuum paste, the above-mentioned dry paste is crushed into fine powder;

b. The raw material Jindenglong dry extract, diluent microcrystalline cellulose, lactose, disintegrant cross-linked polyvinylpyrrolidone, lubricant micropowder silica gel, flavoring agent steviol glycoside, pass through a 80-100 mesh sieve, and set aside;

c. According to the prescription quantity per 1000 tablets as the base, take the raw material Jindenglong dry extract of step b, diluent microcrystalline cellulose 125-150g, lactose 60-80g, disintegrant cross-linked polyvinylpyrrolidone 20g, flavoring agent Mix 2 g of steviol glycosides in a mixer, add 160 mL of 95% ethanol solution of the binder, use a high-speed granulator or a swinging granulator to make soft materials, use a 24-mesh sieve to granulate the soft materials, and dry the wet granules at 60°C dry;

d. After the wet granules are dried, use a 24-mesh sieve to sieve the granules, add 30g of disintegrating agent cross-linked polyvinylpyrrolidone, and 3-5g of lubricant micropowder silica gel, mix well, and press into tablets to obtain brocade lantern dispersible tablets.

Example 3

a. Preparation process of traditional Chinese medicine: Take 2000g of brocade lanterns, add 8 times the amount of 80% ethanol to reflux and extract twice, each time for 3 hours, filter, the filtrate is set aside, combine the filtrate, recover ethanol, concentrate to a relative density of 1.14-1.20( 60℃) clear ointment, add distilled water to disperse to a concentration of 0.25-0.35 g/mL (equivalent to the original drug), adjust the pH value of the liquid to 10, after the D-101 macroporous adsorption resin adsorption time of 30 minutes, the adsorption rate 1-2 BV/h, eluted with 3 BV distilled water after adsorption, then eluted with 3-5 BV of 70% ethanol at a flow rate of 1-2 BV/h, collected the eluate, concentrated, and dried in vacuum paste, the above-mentioned dry paste is crushed into fine powder;

b. The raw material Jindenglong dry extract, diluent microcrystalline cellulose, calcium sulfate, disintegrant croscarmellose sodium starch, low-substituted hydroxypropyl cellulose, lubricant micropowder silica gel, flavoring agent steviol glycoside, viscose Mixture polyvinylpyrrolidone is crushed, passed through 80-100 mesh sieve, and set aside;

c, according to the prescription quantity per 1000 tablets as the base, take the raw material Jindenglong dry extract of step b, diluent microcrystalline cellulose 125-150g, calcium sulfate 60-80g, disintegrant cross-linked sodium carboxymethyl starch 15g, Low-substituted hydroxypropyl cellulose 10g, flavoring agent steviol glycoside 2g, mix in a mixer, add binder 10% polyvinylpyrrolidone ethanol solution 160mL, use high-speed granulator or oscillating granulation machine to make soft material, soft material Granulate with a 24-mesh sieve, and dry the wet granules at 60°C;

d. After the wet granules are dried, use a 24-mesh sieve to sieve the granules, add 15g of disintegrant cross-linked carboxymethyl starch sodium, 10g of low-substituted hydroxypropyl cellulose, 3-5g of lubricant micropowder silica gel, mix well, and press into tablets, that is, Get brocade lantern dispersible tablets.

Example 4

a. Preparation process of traditional Chinese medicine: Take 2000g of brocade lanterns, add 8 times the amount of 80% ethanol to reflux and extract twice, each time for 3 hours, filter, the filtrate is set aside, combine the filtrate, recover ethanol, concentrate to a relative density of 1.14-1.20( 60℃) clear ointment, add distilled water to disperse to a concentration of 0.25-0.35 g/mL (equivalent to the original drug), adjust the pH value of the liquid to 10, after the D-101 macroporous adsorption resin adsorption time of 30 minutes, the adsorption rate 1-2 BV/h, eluted with 3 BV distilled water after adsorption, then eluted with 3-5 BV of 70% ethanol at a flow rate of 1-2 BV/h, collected the eluate, concentrated, and dried in vacuum paste, the above-mentioned dry paste is crushed into fine powder;

b. The raw material Jindenglong dry extract, diluent microcrystalline cellulose, calcium sulfate, disintegrant croscarmellose sodium starch, low-substituted hydroxypropyl cellulose, lubricant micropowder silica gel, flavoring agent steviol glycoside, over 80-100 mesh sieve, spare;

c, according to the prescription quantity per 1000 tablets as the base, take the raw material Jindenglong dry extract of step b, diluent microcrystalline cellulose 125-150g, calcium sulfate 60-80g, disintegrant cross-linked sodium carboxymethyl starch 15g, Low-substituted hydroxypropyl cellulose 10g, flavoring agent steviol glycoside 2g, mix in a mixer, add binder 95% ethanol solution 200mL, use high-speed granulator or oscillating granulation machine to make soft material, use 24 mesh sieve for soft material Granulating, drying wet granules at 60°C;

d. After the wet granules are dried, use a 24-mesh sieve to sieve the granules, add 15g of disintegrant cross-linked carboxymethyl starch sodium, 10g of low-substituted hydroxypropyl cellulose, 3-5g of lubricant micropowder silica gel, mix well, and press into tablets, that is, Get brocade lantern dispersible tablets.

Example 5

a. Preparation process of traditional Chinese medicine: Take 2000g of brocade lanterns, add 8 times the amount of 80% ethanol to reflux and extract twice, each time for 3 hours, filter, the filtrate is set aside, combine the filtrate, recover ethanol, concentrate to a relative density of 1.14-1.20( 60℃) clear ointment, add distilled water to disperse to a concentration of 0.25-0.35 g/mL (equivalent to the original drug), adjust the pH value of the liquid to 10, after the D-101 macroporous adsorption resin adsorption time of 30 minutes, the adsorption rate 1-2 BV/h, eluted with 3 BV distilled water after adsorption, then eluted with 3-5 BV of 70% ethanol at a flow rate of 1-2 BV/h, collected the eluate, concentrated, and dried in vacuum paste, the above-mentioned dry paste is crushed into fine powder;

b. Raw material Jindenglong dry extract, diluent microcrystalline cellulose, calcium sulfate, lactose, disintegrant cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, lubricant micro-powder silica gel , the flavoring agent steviol glycoside, and the binder polyvinylpyrrolidone are pulverized, passed through a 80-100 mesh sieve, and set aside;

c. According to the prescription quantity per 1000 tablets, take the raw material Jindenglong dry extract of step b, diluent microcrystalline cellulose 100-125g, calcium sulfate 50-60g, lactose 50-60g, disintegrant cross-linked polyethylene Pyrrolidone 10g, cross-linked carboxymethyl starch sodium 10g, low-substituted hydroxypropyl cellulose 5g, flavoring agent steviol glycoside 2g were mixed in a mixer, and binder 10% polyvinylpyrrolidone ethanol solution 160mL was added, and the Granulator or oscillating granulator machine soft materials, soft materials are granulated with 24 mesh sieves, and the wet granules are dried at 60°C;

d. After the wet granules are dried, use a 24-mesh sieve to sieve the granules, add 10 g of disintegrant cross-linked polyvinylpyrrolidone, 10 g of cross-linked carboxymethyl starch sodium, 5 g of low-substituted hydroxypropyl cellulose, and 3-5 g of lubricant micro-powder silica gel, Mix well, and press into tablets to obtain brocade lantern dispersible tablets.

Example 6

a. Preparation process of traditional Chinese medicine: Take 2000g of brocade lanterns, add 8 times the amount of 80% ethanol to reflux and extract twice, each time for 3 hours, filter, the filtrate is set aside, combine the filtrate, recover ethanol, concentrate to a relative density of 1.14-1.20( 60℃) clear ointment, add distilled water to disperse to a concentration of 0.25-0.35 g/mL (equivalent to the original drug), adjust the pH value of the liquid to 10, after the D-101 macroporous adsorption resin adsorption time of 30 minutes, the adsorption rate 1-2 BV/h, eluted with 3 BV distilled water after adsorption, then eluted with 3-5 BV of 70% ethanol at a flow rate of 1-2 BV/h, collected the eluate, concentrated, and dried in vacuum paste, the above-mentioned dry paste is crushed into fine powder;

b. Raw material Jindenglong dry extract, diluent microcrystalline cellulose, calcium sulfate, lactose, disintegrant cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, lubricant micro-powder silica gel , the flavoring agent steviol glycoside, passed through a 80-100 mesh sieve, and set aside;

c. According to the prescription quantity per 1000 tablets, take the raw material Jindenglong dry extract of step b, diluent microcrystalline cellulose 100-125g, calcium sulfate 50-60g, lactose 50-60g, disintegrant cross-linked polyethylene Pyrrolidone 10g, cross-linked carboxymethyl starch sodium 10g, low-substituted hydroxypropyl cellulose 5g, flavoring agent steviol glycoside 2g and mix in a mixer, add binder 95% ethanol solution 200mL, use a high-speed granulator or shake Type granulation mechanism soft material, soft material is granulated with a 24 mesh sieve, and the wet granules are dried at 60°C;

d. After the wet granules are dried, use a 24-mesh sieve to sieve the granules, add 10 g of disintegrant cross-linked polyvinylpyrrolidone, 10 g of cross-linked carboxymethyl starch sodium, 5 g of low-substituted hydroxypropyl cellulose, and 3-5 g of lubricant micro-powder silica gel, Mix well, and press into tablets to obtain brocade lantern dispersible tablets.

Claims (5)

1. one kind has the Calyx Seu Fructus Physalis dispersible tablet of hypoglycemic activity, it is characterized in that this dispersible tablet with 1000 for radix, raw material Calyx Seu Fructus Physalis 2000g, diluents microcrystalline cellulose 100-250g, lactose 50-100g, disintegrating agent crospolyvinylpyrrolidone 30-60g, lubricant micropowder silica gel 3-10g, correctives stevioside 1.5-3.0g, binding agent is that the alcoholic solution 50-200mL of 5-10% polyvinylpyrrolidone makes.

2. Calyx Seu Fructus Physalis dispersible tablet as claimed in claim 1, it is characterized in that this dispersible tablet with 1000 for radix, raw material Calyx Seu Fructus Physalis 2000g, diluents microcrystalline cellulose 100-250g, calcium sulfate 50-100g, disintegrating agent crosslinked carboxymethyl fecula sodium 20-40g, low-substituted hydroxypropyl cellulose 10-40g, lubricant micropowder silica gel 3-10g, correctives stevioside 1.5-3.0g, binding agent is that the alcoholic solution 50-200mL of 5-10% polyvinylpyrrolidone makes.

3. Calyx Seu Fructus Physalis dispersible tablet as claimed in claim 1, it is characterized in that this dispersible tablet with 1000 for radix, raw material Calyx Seu Fructus Physalis 2000g, diluents microcrystalline cellulose 100-250g, calcium sulfate 50-100g, disintegrating agent crosslinked carboxymethyl fecula sodium 20-40g, low-substituted hydroxypropyl cellulose 10-40g, lubricant micropowder silica gel 3-10g, correctives stevioside 1.5-3.0g, binding agent is that 95% alcoholic solution 50-200mL makes.

4. Calyx Seu Fructus Physalis dispersible tablet as claimed in claim 1, it is characterized in that this dispersible tablet with 1000 for radix, raw material Calyx Seu Fructus Physalis 2000g, diluents microcrystalline cellulose 100-250g, lactose 50-100g, disintegrating agent crospolyvinylpyrrolidone 30-60g, lubricant micropowder silica gel 3-10g, correctives stevioside 1.5-3.0g, binding agent is that 95% alcoholic solution 50-200mL makes.

5. the preparation method of the Calyx Seu Fructus Physalis dispersible tablet according to claim 1,2,3,4, is characterized in that carrying out according to the following steps:

A, Chinese medicine producing process: get Calyx Seu Fructus Physalis 2000g, add 8 times amount 80% alcohol reflux 2 times, each 3 h, filter, filtrate is for subsequent use, merging filtrate, reclaim ethanol, be concentrated into the clear paste that relative density is 1.14-1.20 (60 DEG C), it is 0.25-0.35 g/mL (being equivalent to crude drug in whole) that adding distil water is dispersed into concentration, medicinal liquid pH value is adjusted to 10, through D-101 type absorption with macroporous adsorbent resin time 30 min, the rate of adsorption is 1-2 BV/h, with 3 BV distilled water eluting after absorption, use the flow velocity eluting of 70% ethanol with 1-2 BV/h of 3-5 BV again, collect eluent, concentrated, vacuum drying becomes dry cream, above-mentioned dried cream powder is broken into fine powder,

B, by raw material Calyx Seu Fructus Physalis dry extract, diluents microcrystalline cellulose, calcium sulfate, lactose, disintegrating agent crospolyvinylpyrrolidone, crosslinked carboxymethyl fecula sodium, low-substituted hydroxypropyl cellulose, lubricant micropowder silica gel, correctives stevioside, polyvinyl pyrrolidone is pulverized, and crosses 80-100 mesh sieve, for subsequent use;

C, by recipe quantity, every 1000 is radix, get the raw material Calyx Seu Fructus Physalis dry extract of step b, diluents microcrystalline cellulose 125-150g, calcium sulfate 60-80g or microcrystalline Cellulose 125-150g, lactose 60-80g or microcrystalline Cellulose 100-125g, calcium sulfate 50-60g, lactose 50-60g, disintegrating agent crosslinked carboxymethyl fecula sodium 15g, low-substituted hydroxypropyl cellulose 10g or crospolyvinylpyrrolidone 20g or crospolyvinylpyrrolidone 10g, crosslinked carboxymethyl fecula sodium 10g, low-substituted hydroxypropyl cellulose 5g, correctives stevioside 2g mixes in mixer, add alcoholic solution or the 95% ethanol 200mL of binding agent 10% polyvinylpyrrolidone, with high-speed granulator or oscillating granulator soft material, soft material 24 mesh sieves are granulated, wet granular is bake drying at 60 DEG C,

After d, wet grain drying, with 24 mesh sieve granulate, add disintegrating agent crosslinked carboxymethyl fecula sodium 15g, low-substituted hydroxypropyl cellulose 10g or crospolyvinylpyrrolidone 30g or crospolyvinylpyrrolidone 10g, crosslinked carboxymethyl fecula sodium 10g, low-substituted hydroxypropyl cellulose 10g, lubricant micropowder silica gel 3-5g, mixing, tabletting, obtains Calyx Seu Fructus Physalis dispersible tablet.