CN1041992C

CN1041992C - Preparation technology of cold resistant panacla tablet

Info

Publication number: CN1041992C
Application number: CN92106023A
Authority: CN
Inventors: 潘浬; 赵喆; 闫桂珍; 曲成基; 胡秀芝; 刘桂琴
Original assignee: SHENYANG TRADITIONAL CHINESE M
Current assignee: SHENYANG TRADITIONAL CHINESE M
Priority date: 1992-01-16
Filing date: 1992-01-16
Publication date: 1999-02-10
Anticipated expiration: 2007-01-16
Also published as: CN1062088A

Abstract

The present invention relates to a technology for preparing a cold resisting tablet having the efficacy of fever relief, pain elimination and fire removal, which is characterized in that a certain quantity of the effective components of radix isatidis and chrysanthemums are extracted; then the effective components are sufficiently mixed with a certain quantity of extracts of berberine, extracts of asiatic moonseed rhizome, paracetamolum powder and artificial bezoar uniformly; a mixture is prepared into granules by ethanol, and the tablet is prepared finally. The present invention is suitable for common cold, nasal obstruction, rhinorrhea, pharyngeal portion gall, cough, headaches, sour pain in a whole body, long-lasting high fever and complications, such as antiaditis, lymphadenitis, etc., caused by the common cold. The present invention has the characteristics of simple technology, abundant medicine source, low cost and portability; furthermore, the tablet is combined and synthesized by Chinese medicines and Western medicines.

Description

Preparation technology of cold resistant panacla tablet

The present invention relates to a kind of Tabules oral medicine technical field, specifically a kind of employing Chinese medicine and western medicine combines, and has the production method of cold resistant tablet of the effect of analgesic, analgesia, antiinflammatory.

As everyone knows, the drug main that is directly used in the treatment human body diseases will divide two big classes, and a class is a Western medicine, and a class is a Chinese medicine.Along with the continuous development of science and technology, Chinese and Western two big class medicines begin to have interpenetrated in processing and application, for example: Chinese herbal medicine is utilized the Western medicine processing extraction technique, extract the active ingredient in the Chinese herbal medicine, and be processed into Chinese medicine unguentum or tablet.We know, use the western medicine curative effect of disease generally very fast, but toxic and side effects are also relatively large, and are just inapplicable to some patients like this; Treatment by Chinese herbs then generally has no side effect, but treatment cycle is longer, and is also inapplicable to the people that some state of an illness are heavier.Therefore, the method that some common medicines adopt Chinese medicine and western medicine to combine is made, just seemed important all the more more effectively to treat disease.

The purpose of this invention is to provide and a kind ofly have comprehensive drug and adopt Chinese medicine and western medicine to combine to produce the new technology of anticold tablet, address the problem of function singleness on existing to alleviate simple employing Western medicine or Chinese medicine.

Realize that the concrete technology characteristics of purpose of the present invention is;

1, the 35-50% that will account in the gross weight 35-40% Radix Isatidis that feeds intake is standby after pulverizing 100 mesh sieves;

2, decoct twice after getting the Flos Chrysanthemi mixing of the Radix Isatidis of surplus and 30-35%, for the first time adding 14 times of amounts of water boiled 1 hour, for the second time add 8 times of amounts of water and boil half an hour, merge filtrate twice, after filtration, leave standstill 12 hours after, draw supernatant, concentrating under reduced pressure becomes cream, and the proportion of cream is 1.25-1.30 (Baume hydrometer 70-80 ℃ measurement).

3, the Radix Isatidis after above-mentioned condensed cream and the pulverizing is stirred; after the drying; the XIAONIEGEN extract that adds 7-10%; the Rhizoma Menispermi extract of 4-7%; mixing and pulverized 100 mesh sieves after, be blended into the paracetamol powder of 10-14%, the artificial bezoar powder of 2-3%, fully make granule with ethanol behind the mixing; dry back is selected grain, is added the Pulvis Talci of prescription gross weight 1%, 0.6% magnesium stearate again, and tabletting, sugar coating are promptly behind the mixing.

The optimum weight percentage ratio of medicine that the present invention drops into is:

Artificial Calculus Bovis's 2.76% acetaminophen 11.51%

XIAONIEGEN extract 8.10% Radix Isatidis 38.57%

Rhizoma Menispermi extract 5.35% Flos Chrysanthemi 33.71%.

The present invention is owing to adopt Flos Chrysanthemi, Radix Isatidis, artificial Calculus Bovis, berberine, dauricine and acetaminophen etc. to develop, and therefore has effects such as analgesic, analgesia, antiinflammatory.In view of Flos Chrysanthemi is the wind heat clearing away of loosing, the suppressing the hyperactive liver medicine that makes eye bright, be used for anemopyretic cold, headache, dizzy, conjunctival congestion and swelling pain, hypertension, have the effect of tonifying YIN heat-clearing and toxic substances removing, influenza virus there is good inhibition effect; Radix Isatidis is the heat-clearing and toxic substances removing blood-cooling drugs, is used for epidemic febrile disease heating, anemopyretic cold, laryngopharynx swelling and pain, epidemic encephalitis type B etc., has good antibacterial action, and influenza, epidemic encephalitis, encephalitis b, scarlet fever are had good curative effect; Artificial Calculus Bovis, berberine and dauricine have clear away heart-fire, effect such as detoxifcation, anti-inflammatory analgetic; And acetaminophen can analgesic, analgesia.Therefore, medicament of the present invention all plays ideal therapeutic effect to various anemofrigid cold or anemopyretic cold.After taking medicine, not only alleviate General Symptoms, it is rapid to eliminate nose mucositis dress phenomenon, also effective to improving respiratory tract and symptom of digestive tract.The present invention is the Chinese medicine and western medicine mixture, has excavated the medical treasure-house of China, has used the characteristics of modern medicine.This medicine not only is better than the medicine of other treatment flu for the treatment flu, and has no side effect, and also can treat diseases such as upper respiratory tract infection, intrapulmonary infection, cholecystitis, urinary tract infection, rheumatism and tracheitis.Characteristics such as also to have processing technology simple in the present invention in addition, and abundant, with low cost, the synthetic tablet in medicine source is easy to carry.

Below in conjunction with accompanying drawing embodiment of the present invention are further described in detail.

Fig. 1 is a process flow diagram of the present invention.

Embodiment 1

Present embodiment is the technological process of adopting Fig. 1, with the dosage that to produce 1000 coated tablets be unit, wherein:

Artificial Calculus Bovis's 17 gram acetaminophen 71 grams

XIAONIEGEN extract 50 gram Radix Isatidis 238 grams

Rhizoma Menispermi extract 33 gram Flos Chrysanthemis 208 grams

Annotate: contained berberine hydrochloride must not be less than 70% in the XIAONIEGEN extract, and contained dauricine must not be less than 25% in the Rhizoma Menispermi extract.

Operational process of craft;

1, pulverize: get Radix Isatidis coarse fodder 103 grams, after pulverizing 100 mesh sieves, standby.

2, decoct: other gets Radix Isatidis coarse fodder 135 grams, Flos Chrysanthemi 208 grams, decoct twice, for the first time add 14 times of amounts of water and boiled 1 hour, add 8 times of water gagings for the second time and boil half an hour, filter, filtrate was left standstill 12 hours, draw the supernatant concentrating under reduced pressure and become cream, proportion is that the wet cream rate of 1.25-1.30 (Baume hydrometer 70-80 ℃ survey) is about 30%, and dried cream rate is about 20%.

3, pelletizing press sheet: condensed cream and Radix Isatidis powder are stirred, and dry (below 80 ℃) add XIAONIEGEN extract 50 grams then; Rhizoma Menispermi extract 33 grams stir and pulverized 120 mesh sieves, are blended into paracetamol powder (fineness requirement 100 orders) 71 grams again; artificial Calculus Bovis's 17 grams; make soft material with 95% ethanol behind the mixing, granulate dry (70-80 ℃), the choosing grain with 14 mesh sieves; 1% Pulvis Talci that adds total inventory again; 0.6% magnesium stearate, tabletting behind the mixing, sugar coating is finished product.

Claims

1, a kind of preparation technology of cold resistant panacla tablet with effect of analgesic, analgesia, antiinflammatory is characterized in that:

(1), the 35-50% that will account in the gross weight 35-40% Radix Isatidis that feeds intake is standby after pulverizing 100 mesh sieves;

(2), decoct twice after getting the Flos Chrysanthemi mixing of the Radix Isatidis of surplus and 30-35%, for the first time adding 14 times of amounts of water boiled 1 hour, for the second time add 8 times of amounts of water and boil half an hour, merge filtrate twice, after filtration, leave standstill 12 hours after, draw supernatant, concentrating under reduced pressure becomes cream, and the proportion of cream is 1.25-1.30 (70-80 ℃ of measurement of ripple English gravimeter);

(3), the Radix Isatidis after above-mentioned condensed cream and the pulverizing is stirred; after the drying; the XIAONIEGEN extract that adds 7-10%; the Rhizoma Menispermi extract of 4-7%; mixing and pulverized 100 mesh sieves after, be blended into the paracetamol powder of 10-14%, the artificial bezoar powder of 2-3%, fully make granule with ethanol behind the mixing; dry back is selected grain, is added the Pulvis Talci of prescription gross weight 1%, 0.6% magnesium stearate again, and tabletting, sugar coating are promptly behind the mixing.

2, anticold tablet reparation technology according to claim 1 is characterized in that the percentage by weight of the medicine that drops into is:

Artificial Calculus Bovis's 2.76% acetaminophen 11.51%

XIAONIEGEN extract 8.10% Radix Isatidis 38.57%

Rhizoma Menispermi extract 5.35% Flos Chrysanthemi 33.71%.

3, preparation technology of cold resistant panacla tablet according to claim 1 and 2 is characterized in that: contained berberine hydrochloride must not be less than 70% in the XIAONIEGEN extract, and contained dauricine must not be less than 25% in the Rhizoma Menispermi extract.