CN208013154U - Automatic change quick check out test set - Google Patents

Abstract

The utility model discloses an automatic rapid detection device, which has reasonable structure and ingenious design and is characterized in that the unique double enrichment purification switching design and the mutual switching coordination of a plurality of valves are utilized, the enrichment purification operation and the sample injection operation can be mutually split in the whole analysis experiment, the enrichment purification of a second channel is simultaneously carried out when the sample injection analysis of the first channel is carried out, the enrichment purification of the first channel is simultaneously carried out when the sample injection analysis of the second channel is carried out, and the analogy is also carried out; the unique double enrichment and purification switching technology greatly shortens the analysis period of each sample, greatly improves the use efficiency of the instrument and reduces the average cost of analyzing the samples; the functions of a plurality of sets of processing and detecting equipment are realized by one instrument, and the acquisition cost of the instrument is reduced; the user only needs to operate one device to realize enrichment purification, sample introduction separation, mixed reaction and analysis detection of the sample, and the experimental operation is greatly simplified.

Description

A kind of automatic rapid detection equipment

technical field

The utility model relates to the field of liquid chromatography, in particular to an automatic rapid detection device.

Background technique

With the development of modern chemical technology, thanks to the application of new materials, microelectronics, micromachining and other modern technologies, analytical chemistry, especially instrumental analytical chemistry, has made great progress and progress. As an important branch of instrumental analytical chemistry, the super strong separation and analysis capabilities of high performance liquid chromatography make it widely used in many fields such as petrochemical, organic synthesis, physiology and biochemistry, medicine and health, and space exploration, and has become an extremely important and indispensable means.

In recent years, with the advancement of technology and the increase of labor costs, the degree of automation of high performance liquid chromatography has become higher and higher. The emergence of automated devices has greatly improved the continuous working ability of liquid chromatography, improved work efficiency, and reduced Labor cost when using the instrument.

Although the automation of HPLC analysis has been relatively high, with the expansion of the scope of research, the source of samples tends to be more complex, and chemical analysts need to spend a lot of energy on pretreatment of samples to obtain samples suitable for HPLC. The analyzed substances and the processed substances also need to be manually put into high-performance liquid chromatography, resulting in insufficient automation of the entire experimental process and high requirements for operators. Many grassroots laboratories do not have the above conditions.

Need a kind of automatic rapid detection equipment that can solve the above problems now.

Contents of the invention

The utility model aims to solve the above-mentioned shortcomings in the prior art, and proposes an automatic rapid detection device with high integration, simple user operation, high degree of automation, and accurate and reliable results.

The technical solution of the utility model is: an automatic rapid detection equipment, characterized in that: the equipment includes a two-position six-way valve 11, and the two-position six-way valve 11 connects with the two-position three-way valve 12 through the pipeline. connected, and the two-position three-way valve is connected with the cleaning solvent bottle 1 through the first two-position T-shaped valve 8, and the first two-position T-shaped valve 8 is also provided with a syringe 7,

The two-position six-way valve 11 is also connected to the two-position ten-way valve 13 through a pipeline, and the first enrichment purification column 14 and the second enrichment purification column 15 are respectively connected to the two-position ten-way valve 13, and the two The ten-way valve 13 is also connected to the sample needle 16 through a pipeline, and the sample needle 16 is also equipped with a cleaner 18,

The two-position six-way valve 11 is also connected to the second two-position T-type valve 10 through a pipeline, and the described equipment also includes a plurality of solvent bottles, and these solvent bottles are connected to the solvent pump 9 through the distribution proportional solenoid valve 6, and The outlet port of the displacement pump 9 is connected to a port of the second two-position T-type valve 10 through a pipeline,

The two-position ten-way valve 13 is also connected to the analytical chromatographic column 21 through a pipeline, and the analytical chromatographic column 21 is connected to the mixing reactor 22, and the inlet port of the mixing reactor 22 is connected to the first solvent delivery pump 19 and the second solvent delivery pump 19 respectively. The two solvent delivery pumps 20 are connected, and the outlet end of the mixing reactor 22 is connected with the detector 23, and the outlet end of the detector 23 is connected with the waste liquid container 24 through a pipeline,

The two-position three-way valve 12 is also connected to the waste liquid container 24 through a pipeline,

The device also includes a sample tray 17 on which a plurality of sample vials are arranged.

Compared with the prior art, the utility model has the following advantages:

This type of automatic rapid detection equipment has a reasonable structure and ingenious design. Its biggest feature is that it can use the unique double-enrichment purification switching design and the mutual switching of multiple valves to combine the enrichment and purification during the entire analysis experiment. The purification operation and the sampling operation are separated from each other. When the first channel is injected and analyzed, the enrichment and purification of the second channel is carried out at the same time, and when the second channel is injected and analyzed, the enrichment and purification of the first channel is carried out at the same time, and And so on; its unique dual-enrichment purification switching technology greatly reduces the analysis cycle of each sample, greatly improves the use efficiency of the instrument, and reduces the average cost of analyzing samples; it uses one instrument to realize multiple sets of The functions of processing and testing equipment reduce the cost of instrument purchase; users only need to operate one piece of equipment to achieve sample enrichment and purification, sample separation, mixed reaction, analysis and detection, which greatly simplifies the experimental operation; , mix any kind of solvents in multiple solvent bottles in any proportion to form a solution, not only the ratio is accurate, but also can be adjusted appropriately according to the actual sample situation, ready to use, no solvent waste, reducing the cost of solvent use, reducing Less environmental pollution. Therefore, it can be said that this automatic rapid detection equipment has the above-mentioned series of advantages, and is especially suitable for popularization and application in this field, and its market prospect is very broad.

Description of drawings

Fig. 1 is a structural schematic diagram of an exhaust state of an embodiment of the present invention.

Fig. 2 is a schematic structural view of the cleaning state of the second enrichment and purification column in the embodiment of the present invention.

Fig. 3 is a structural schematic diagram of the cleaning state of the first enrichment and purification column in the embodiment of the present invention.

Fig. 4 is a schematic structural diagram of the activated state of the second enrichment and purification column in the embodiment of the present invention.

Fig. 5 is a schematic structural view of the activated state of the first enrichment and purification column in the embodiment of the present invention.

Fig. 6 is a schematic structural view of the loading of the second enrichment and purification column and the analysis state of the first enrichment and purification column in the embodiment of the present invention.

Fig. 7 is a schematic structural view of the loading of the first enrichment and purification column and the analysis state of the second enrichment and purification column in the embodiment of the present invention.

Detailed ways

The specific embodiment of the utility model will be described below in conjunction with the accompanying drawings. As shown in Figures 1 to 7: an automatic rapid detection device, including a two-position six-way valve 11, the two-position six-way valve 11 is connected to the two-position three-way valve 12 through a pipeline, and the two-position three-way valve is Connect to the cleaning solvent bottle 1 through the first two-position T-shaped valve 8, and the first two-position T-shaped valve 8 is also provided with a syringe 7,

The above-mentioned two-position six-way valve 11 is also connected to the two-position ten-way valve 13 through a pipeline, and the first enrichment purification column 14 and the second enrichment purification column 15 are respectively connected to the two-position ten-way valve 13, and the two The ten-way valve 13 is also connected to the sample needle 16 through a pipeline, and the sample needle 16 is also equipped with a cleaner 18,

The two-position six-way valve 11 is also connected to the second two-position T-type valve 10 through pipelines, and the described equipment also includes a plurality of solvent bottles, and these solvent bottles are connected to the solvent pump 9 through the distribution proportional electromagnetic valve 6, and the positive displacement pump The outlet port of 9 is connected to a port of the second two-position T-type valve 10 through a pipeline,

The two-position ten-way valve 13 is also connected to the analytical chromatographic column 21 through a pipeline, and the analytical chromatographic column 21 is then connected to the mixing reactor 22, and the inlet port of the mixing reactor 22 is connected with the first solvent delivery pump 19 and the second solvent respectively. The transfer pump 20 is connected, and the outlet end of the mixing reactor 22 is connected with the detector 23, and the outlet end of the detector 23 is connected with the waste liquid container 24 through a pipeline,

The two-position three-way valve 12 is also connected to the waste liquid container 24 through a pipeline,

The device also includes a sample tray 17 on which a plurality of sample vials are arranged.

The working process of the automatic rapid detection equipment of the utility model patent embodiment is as follows: the equipment can sequentially realize the exhaust step, the cleaning step of the second enrichment purification column 15, the cleaning step of the first enrichment purification column 14, the second enrichment purification column 14 cleaning step, and the second enrichment purification column 14. The activation step of the collection purification column 15, the activation step of the first enrichment purification column 14, the loading of the second enrichment purification column 15, the analysis step of the first enrichment purification column 14, the loading of the first enrichment purification column 14, the second The second enrichment purification column 15 analysis steps.

Exhaust step (as shown in Figure 1): In this step, the two-position three-way valve 12 is switched to the state where the first two-position T-valve 8 is connected to the exhaust pipeline, and the cleaning solvent bottle 1 is temporarily removed , first use the syringe 7 to suck air into the pipeline (at this time the side of the first two-position T-valve 8 connected to the two-position three-way valve 12 is closed), and then blow the air through the two-position three-way valve 12 To the exhaust pipeline (at this time, the side connected to the first and second T-shaped valve 8 gas inlet pipeline is closed), and finally discharged. This step can discharge the gas remaining in the pipeline after the last work.

Cleaning steps of the second enrichment and purification column 15 (as shown in Figure 2): In this step, the two-position three-way valve 12, the two-position six-way valve 11 and the two-position ten-way valve 13 perform switching actions respectively to rebuild The pipeline connection method of this system allows the cleaning solvent bottle 1 to pass through the first two-position T-shaped valve 8, the two-position three-way valve 12, the two-position six-way valve 11, the two-position ten-way valve 13 and the second enrichment purification The column 15 is connected to the sample needle 16; the cleaning solvent in the cleaning solvent bottle 1 is sucked into the pipeline by the syringe 7 (at this time, the side connecting the first two-position T-valve 8 and the two-position three-way valve 12 is closed), Then the cleaning solvent is sent into the two-position six-way valve 11, the two-position ten-way valve 13 and the second enrichment purification column 15 through the two-position three-way valve 12 (at this time, the first two-position T-type valve 8 enters the liquid The side connected to the pipeline is closed), after the cleaning solvent enters the second enrichment and purification column 15, it is cleaned, and the used cleaning solvent after cleaning will enter the cleaner 18 to complete the second enrichment and purification column 15 washes.

The cleaning step of the first enrichment and purification column 14 (as shown in Figure 3): In this step, the two-position three-way valve 12, the two-position six-way valve 11 and the two-position ten-way valve 13 perform switching actions respectively to rebuild The pipeline connection mode of this system allows the cleaning solvent bottle 1 to pass through the first two-position T-valve 8, the two-position three-way valve 12, the two-position six-way valve 11, the two-position ten-way valve 13 and the first enrichment purification The column 14 is connected to the sample needle 16; use the syringe 7 to suck the cleaning solvent in the cleaning solvent bottle 1 into the pipeline (at this time, the side where the first two-position T-valve 8 is connected to the two-position three-way valve 12 is closed), Then the cleaning solvent is sent into the two-position six-way valve 11, the two-position ten-way valve 13 and the first enrichment purification column 14 sequentially through the two-position three-way valve 12 (at this time, the first two-position T-type valve 8 enters the liquid The side connected to the pipeline is closed), after the cleaning solvent enters the first enrichment purification column 14, it is cleaned, and the used cleaning solvent after cleaning will enter the cleaner 18 to complete the first enrichment purification column 14 washes.

The activation step of the second enrichment and purification column 15 (as shown in Figure 4): In this step, the two-position six-way valve 11 and the two-position ten-way valve 13 perform switching actions respectively to rebuild the pipeline connection mode of the system , the solvent pump 9, the two-position six-way valve 11, the second enrichment and purification column 15 are connected to the sample needle 16; the solvent is extracted from multiple solvent bottles by using the distribution ratio solenoid valve 6, and the distribution ratio solenoid valve 6 can ensure that it enters the system The ratio between various solvents, the mixed solvent enters the second enrichment and purification column 15 through the two-position six-way valve 11 and the two-position ten-way valve 13 under the action of the solvent pump 9, and the second enrichment and purification column 15 is activated. The mixed solvent is directly discharged into the washer 18 through the sample needle 16 to complete the activation step of the second enrichment and purification column 15 .

The activation step of the first enrichment and purification column 14 (as shown in Figure 5): In this step, the two-position six-way valve 11 and the two-position ten-way valve 13 perform switching actions respectively to rebuild the pipeline connection mode of the system , the solvent pump 9, the two-position six-way valve 11, the first enrichment and purification column 14 are connected to the sample needle 16; the solvent is extracted from multiple solvent bottles by using the distribution ratio solenoid valve 6, and the distribution ratio solenoid valve 6 can ensure that it enters the system The ratio between various solvents, the mixed solvent enters the first enrichment and purification column 14 through the two-position six-way valve 11 and the two-position ten-way valve 13 under the action of the solvent pump 9, and the first enrichment and purification column 14 is activated. The mixed solvent is directly discharged into the washer 18 through the sample needle 16 to complete the activation step of the first enrichment and purification column 14 .

Sample loading on the second enrichment and purification column 15 (as shown in Figure 6): In this step, the two-position three-way valve 12, the two-position six-way valve 11 and the two-position ten-way valve 13 perform switching actions respectively to rebuild the The pipeline connection method of the system connects the first two-position T-valve 8, the two-position three-way valve 12, the two-position six-way valve 11, the two-position ten-way valve 13, the second enrichment purification column 15 and the sample needle 16 At the same time, the solvent pump 9, the two-position six-way valve 11, the two-position ten-way valve 13, the first enrichment purification column 14 and the analysis chromatographic column 21 are connected; the power is provided by the syringe 7, and the sample needle 16 is used to remove the sample from the sample tray 17. A sample is extracted from a certain sample bottle, and the sample enters the second enrichment purification column 15 to realize the sample loading step of the second enrichment purification column 15 .

The first enrichment purification column 14 loading, the second enrichment purification column 15 analysis steps (as shown in Figure 7): In this step, the two-position three-way valve 12, the two-position six-way valve 11 and the two-position ten-way The valves 13 perform switching actions respectively to rebuild the pipeline connection mode of the system, so that the first two-position T-shaped valve 8, the two-position three-way valve 12, the two-position six-way valve 11, the two-position ten-way valve 13, the first The enrichment and purification column 14 is connected with the sample needle 16, and the solvent pump 9, the two-position six-way valve 11, the two-position ten-way valve 13, the second enrichment and purification column 15 are connected with the analysis chromatographic column 21; the power is provided by the syringe 7 , using the sample needle 16 to extract a sample from a certain sample bottle on the sample tray 17, and the sample enters the first enrichment purification column 14 to realize the loading step of the first enrichment purification column 14;

At the same time, use the distribution ratio solenoid valve 6 to extract solvents from multiple solvent bottles, the distribution ratio solenoid valve 6 can ensure the ratio between various solvents entering the system, and the mixed solvent passes through the two-position six The through valve 11 and the two-position ten-way valve 13 enter the second enrichment purification column 15, and together with the samples that have been located in the second enrichment purification column 15 before, enter the analytical chromatography column 21, and enter the mixing reactor 22 after the mixed reaction , transported to the special detector 23 for detection and analysis; after the analysis, the discarded solution is directly discharged into the waste liquid container 24; Analysis steps for purification column 15.

The second enrichment purification column 15 loading, the first enrichment purification column 14 analysis steps (as shown in Figure 6): In this step, the two-position three-way valve 12, the two-position six-way valve 11 and the two-position ten-way The valves 13 perform switching actions respectively, and rebuild the pipeline connection mode of this system, so that the first two-position T-shaped valve 8, the two-position three-way valve 12, the two-position six-way valve 11, the two-position ten-way valve 13, the second The enrichment and purification column 15 is connected with the sample needle 16, and at the same time, the solvent pump 9, the two-position six-way valve 11, the two-position ten-way valve 13, the first enrichment and purification column 14 are connected with the analysis chromatographic column 21; the power is provided by the syringe 7 , use the sample needle 16 to extract a sample from a certain sample bottle on the sample tray 17, and the sample enters the second enrichment purification column 15 to realize the sample loading step of the second enrichment purification column 15;

At the same time, use the distribution ratio solenoid valve 6 to extract solvents from multiple solvent bottles, the distribution ratio solenoid valve 6 can ensure the ratio between various solvents entering the system, and the mixed solvent passes through the two-position six The through valve 11 and the two-position ten-way valve 13 enter the first enrichment and purification column 14, and together with the samples that have been in the first enrichment and purification column 14 before, enter the analytical chromatographic column 21, and enter the mixing reactor 22 after the mixed reaction , transported to the special detector 23 for detection and analysis; after the analysis, the discarded solution is directly discharged into the waste liquid container 24; Analysis steps for purification column 14.

After all the analysis is over, the two-position three-way valve 12, the two-position six-way valve 11 and the two-position ten-way valve 13 respectively perform switching actions to rebuild the pipeline connection mode of the system and restore the equipment to the state shown in the figure. 4 and FIG. 5 , reactivate the second enrichment purification column and the first enrichment purification column respectively, and finally discharge all liquid substances remaining in the device into the waste liquid container 24 .

Claims (1)

1. An automatic rapid detection equipment, characterized in that: the equipment includes a two-position six-way valve (11), and the two-position six-way valve (11) is connected to the two-position three-way valve (12) through a pipeline , while the two-position three-way valve is connected to the cleaning solvent bottle (1) through the first two-position T-valve (8), and the first two-position T-valve (8) is also provided with a syringe (7), The two-position six-way valve (11) is also connected to the two-position ten-way valve (13) through pipelines, and the two-position ten-way valve (13) is respectively connected with the first enrichment and purification column (14) and the second Enrichment and purification column (15), at the same time, the two-position ten-way valve (13) is also connected to the sample needle (16) through the pipeline, and the sample needle (16) is also equipped with a cleaner (18), The two-position six-way valve (11) is also connected to the second two-position T-valve (10) through pipelines, and the equipment also includes a plurality of solvent bottles, and these solvent bottles communicate with the proportional solenoid valve (6) The displacement pump (9) is connected, and the outlet port of the displacement pump (9) is connected with a port of the second two-position T-valve (10) through a pipeline, The two-position ten-way valve (13) is also connected to the analytical chromatographic column (21) through a pipeline, and the analytical chromatographic column (21) is connected to the mixing reactor (22), and the inlet port of the mixing reactor (22) They are respectively connected to the first solvent delivery pump (19) and the second solvent delivery pump (20), while the outlet port of the mixing reactor (22) is connected to the detector (23), and the outlet port of the detector (23) is passed through The tubing is connected to the waste container (24), The two-position three-way valve (12) is also connected to the waste liquid container (24) through a pipeline, The device also includes a sample tray (17), and a plurality of sample bottles are arranged on the sample tray (17).