CN204890946U - High diffusion microneedle structure - Google Patents
High diffusion microneedle structure Download PDFInfo
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- CN204890946U CN204890946U CN201520641914.6U CN201520641914U CN204890946U CN 204890946 U CN204890946 U CN 204890946U CN 201520641914 U CN201520641914 U CN 201520641914U CN 204890946 U CN204890946 U CN 204890946U
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- China
- Prior art keywords
- magnetic field
- medicament
- base material
- high diffusivity
- micropin
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- Expired - Fee Related
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- 238000009792 diffusion process Methods 0.000 title abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 20
- 239000011324 bead Substances 0.000 claims description 7
- 150000001450 anions Chemical group 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 abstract description 6
- 108010022355 Fibroins Proteins 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000001727 in vivo Methods 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 abstract 4
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 229940052961 longrange Drugs 0.000 abstract 1
- 230000003796 beauty Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229920000867 polyelectrolyte Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Magnetic Treatment Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The utility model provides a high diffusion microneedle structure includes the substrate, the array protrusion is pressed and the cavity micropin of formation to one side to the substrate, the opposite side of substrate is provided with closed film, pack the medicament between substrate and the closed film, it has the ion water including silk fibroin to mix in the medicament, be provided with perpendicular magnetic field through its axis on the cavity micropin, the utility model discloses because ion water electrically charged receives the long -range navigation of toroidal magnetic field is thatched the masterpiece and is used in to diffusion all around behind the outflow cavity micropin, does benefit to the mixture flow and the diffusion in vivo of medicament and ion water, the absorption rate of increase skin.
Description
Technical field
This utility model relates to health-care medical Material Field, especially, is a kind of high diffusivity microneedle configuration.
Background technology
Beauty treatment micropin utilizes many small syringe needles on micropin roller, chafe, and within very short time, micropin can be made more than 200,000 microtubule, by the regeneration of stimulation collagen, reaches the object of beauty treatment.Along with the development of micro-processing technology, a kind ofly sting expelling pathogenic factors from the exterior skin but do not injure corium and neural micropin technology was come out, for transdermal administration brings new thinking before the more than ten years.Size pierces through the skin surface (horny layer) of permeability extreme difference at micron-sized micropin dot matrix in the mode of reversible Wicresoft, causes biomacromolecule to be able to the mechanical passage passed through, and does not but produce pain and skin trauma.Thrust preferably to change skin permeation sexuality though conventional metals, glass, siliceous micropin possess, but generally medicine is applied in microneedle surface, drug loading is little, is difficult to reach therapeutic effect.Therefore, there is the empty micropin structure of coating medicine in micropin inside, the medicine of q.s can be made to enter the skin corium of skin by empty micropin.But be which kind of micropin all because for large bolus injection in the local short time of skin, and make the absorbtivity of the tissue in skin to medicine uneven.
Utility model content
In order to solve the problem, the purpose of this utility model is to provide a kind of high diffusivity microneedle configuration, and this high diffusivity microneedle configuration can make drug diffusion even.
This utility model solves the technical scheme that its technical problem adopts:
This high diffusivity microneedle configuration comprises base material, described base material is pressed array and is protruded and the hollow microneedles of formation to side, the opposite side of described base material is provided with closed film, filling medicament between described base material and closed film, be mixed with ionized water in described medicament, described hollow microneedles be provided with the magnetic field perpendicular through its axis.
As preferably, in described medicament, be also mixed with fibroin albumen.
As preferably, described magnetic field is the toroidal magnetic field centered by base material.
As preferably, described magnetic field is coordinated by spaced magnetic bead in the non-protruding portion of described closed film or base material and is formed.
As preferably, the both sides of described hollow microneedles are at least respectively provided with a magnetic bead.
As preferably, by micro-electric current in described hollow microneedles.
As preferably, described ionized water is anion water.
As preferably, the ratio that described ionized water accounts for described medicament and ionized water is no less than 20%.
The utility model has the advantage of:
The micromolecule characteristic of ionized water, makes the medicament be dissolved in wherein more easily be absorbed, and fibroin albumen, can stabilizing ion and medicine as polyelectrolyte, makes it produce precipitation.Simultaneously, the mixture of medicament and ionized water flows along hollow microneedles, due to ionized water the electrically charged Lorentz force being subject to described toroidal magnetic field act on and to flow out after hollow microneedles to surrounding diffusion, the mixture being beneficial to medicament and ionized water flowing in vivo and diffusion, increase the absorbance of skin.
Accompanying drawing explanation
Fig. 1 be this high diffusivity microneedle configuration face generalized section.
Fig. 2 be this high diffusivity microneedle configuration medicament face stressed schematic diagram.
Fig. 3 is the force analysis perspective diagram of this high diffusivity microneedle configuration medicament.
Detailed description of the invention
Below in conjunction with drawings and Examples, this utility model is further illustrated:
Embodiment one:
In the present embodiment, consult Fig. 1, this high diffusivity microneedle configuration comprises base material 120, described base material 120 is pressed array and is protruded and the hollow microneedles 100 of formation to side, the opposite side of described base material 120 is provided with closed film 300, filling medicament between described base material 120 and closed film 300, is mixed with the ionized water containing fibroin albumen in described medicament, described hollow microneedles 100 is provided with the magnetic field perpendicular through its axis.
Fibroin albumen, can stabilizing ion and medicine as polyelectrolyte, makes it produce precipitation.
Consult Fig. 3, described magnetic field is the toroidal magnetic field centered by base material 120, and described magnetic field is coordinated by spaced magnetic bead 200 in the non-protruding portion of described closed film 300 or base material 120 and formed, and the position, direction of magnetic bead 200 as shown in the figure.
Certainly, in a further embodiment, the magnetic field of annular is also formed by the wire of energising, and wire is vertically set on base material 120 center.
Above-mentioned high diffusivity microneedle configuration, the both sides of described hollow microneedles 100 are at least respectively provided with a magnetic bead, make more accurate by the magnetic direction of hollow microneedles 100 and keep certain magnetic field intensity.
Above-mentioned high diffusivity microneedle configuration, described ionized water is anion water, and the ratio that described ionized water accounts for described medicament and ionized water is no less than 20%, keeps the ratio of ionized water, makes ionized water more be subject to magnetic field force effect and spread.Ionized water is not only very clean, and containing fresh oxygen and mineral, be rich in lot of pure ionized calcium, human absorptivity reaches more than 95%.The more important thing is that its micel is little, dissolubility is large, and penetration is strong, and energy is large, very similar to molecular structure water in body, be easy to the mass exchange participating in cell, enhance metabolism, improve immunity of organisms, reduce blood viscosity, to the tens of kinds of chronic diseases caused by acidic physique.
The operation logic of the high diffusivity microneedle configuration in the above embodiments:
Consult Fig. 2 and Fig. 3,-q, 110 for negatron, B be magnetic field, f is stressed, v is the direction of motion, after hollow microneedles 100 acts on skin, the mixture of medicament and ionized water flows along hollow microneedles 100, due to ionized water the electrically charged Lorentz force being subject to described toroidal magnetic field act on and flow out hollow microneedles 100 Hou You center to surrounding diffusion (observe-q in Fig. 3,110 stressed).
Embodiment two:
Only in embodiment one, pass through micro-electric current by described hollow microneedles 100, by being arranged on the electrode at hollow microneedles 100 two ends, electric current is formed in hollow microneedles 100, the mixture of medicament and ionized water is made to pass through electric current, the magnetic field that electric current produces makes the medicament of band ionized water be subject to the active force of Lorentz force more by force, and medicament and the easier direction along base material 120 center to surrounding of ionized water mixture are spread.
Describedly be only preferred embodiment of the present utility model, not in order to limit this utility model, all within spirit of the present utility model and principle, any amendment done, equivalent replacement, improvement etc., all should be included in protection domain of the present utility model.
Claims (6)
1. a high diffusivity microneedle configuration, comprises base material (120), and described base material (120) is pressed array and protruded and the hollow microneedles (100) of formation to side, it is characterized in that:
The opposite side of described base material (120) is provided with closed film (300), filling medicament between described base material (120) and closed film (300), be mixed with ionized water in described medicament, described hollow microneedles (100) be provided with the magnetic field perpendicular through its axis.
2. high diffusivity microneedle configuration according to claim 1, is characterized in that: described magnetic field is the toroidal magnetic field centered by base material (120).
3. according to high diffusivity microneedle configuration according to claim 1 or claim 2, it is characterized in that: described magnetic field is coordinated by spaced magnetic bead (200) in the non-protruding portion of described closed film (300) or base material (120) and formed.
4. high diffusivity microneedle configuration according to claim 3, is characterized in that: the both sides of described hollow microneedles (100) are at least respectively provided with a magnetic bead.
5. high diffusivity microneedle configuration according to claim 1, is characterized in that: by micro-electric current in described hollow microneedles (100).
6. high diffusivity microneedle configuration according to claim 1, is characterized in that: described ionized water is anion water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520641914.6U CN204890946U (en) | 2015-08-24 | 2015-08-24 | High diffusion microneedle structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520641914.6U CN204890946U (en) | 2015-08-24 | 2015-08-24 | High diffusion microneedle structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204890946U true CN204890946U (en) | 2015-12-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520641914.6U Expired - Fee Related CN204890946U (en) | 2015-08-24 | 2015-08-24 | High diffusion microneedle structure |
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| CN (1) | CN204890946U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031809A (en) * | 2015-08-24 | 2015-11-11 | 苏州先蚕丝绸生物科技有限公司 | High-diffusion microneedle structure |
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2015
- 2015-08-24 CN CN201520641914.6U patent/CN204890946U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031809A (en) * | 2015-08-24 | 2015-11-11 | 苏州先蚕丝绸生物科技有限公司 | High-diffusion microneedle structure |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151223 Termination date: 20160824 |