CN204910482U - Even microneedle structure that presses - Google Patents
Even microneedle structure that presses Download PDFInfo
- Publication number
- CN204910482U CN204910482U CN201520641603.XU CN201520641603U CN204910482U CN 204910482 U CN204910482 U CN 204910482U CN 201520641603 U CN201520641603 U CN 201520641603U CN 204910482 U CN204910482 U CN 204910482U
- Authority
- CN
- China
- Prior art keywords
- imbibition
- silk fibroin
- micropin
- swelling material
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000463 material Substances 0.000 claims abstract description 55
- 238000005213 imbibition Methods 0.000 claims abstract description 35
- 239000003814 drug Substances 0.000 claims abstract description 22
- 108010022355 Fibroins Proteins 0.000 claims abstract description 13
- 238000007789 sealing Methods 0.000 claims abstract description 13
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims description 9
- 239000000084 colloidal system Substances 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000008961 swelling Effects 0.000 abstract 6
- 239000000758 substrate Substances 0.000 abstract 5
- 238000002955 isolation Methods 0.000 abstract 3
- 230000003796 beauty Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229920002529 medical grade silicone Polymers 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The utility model provides an even microneedle structure that presses includes the substrate, the array protrusion is pressed and the cavity micropin of formation to one side to the substrate, the opposite side of substrate is provided with closed film, it is provided with moisture self -restraint layer to seal between film and the substrate, the root of cavity micropin is provided with silk fibroin imbibition swelling material, be provided with the isolation layer of sealed silk fibroin imbibition swelling material on the substrate, puncture on sealing the film the needle -like portion of isolation layer, be provided with in the cavity micropin with the medicament bag that silk fibroin imbibition swelling material suited, the utility model discloses well needle -like portion punctures the isolation layer, moisture gets into silk fibroin imbibition swelling material, silk fibroin imbibition swelling material inflation is ejecting to the skin corium with the medicament bag, because when making, has confirmed the silk fibroin's in every cavity micropin volume promptly, therefore silk fibroin imbibition swelling material can be even pours into the medicament to the skin corium into, improves the absorption rate of medicament.
Description
Technical field
This utility model relates to medical and beauty treatment health-care material field, especially, is a kind of even pressure microneedle configuration.
Background technology
Beauty treatment micropin utilizes many small syringe needles on micropin roller, chafe, and within very short time, micropin can be made more than 200,000 microtubule, by the regeneration of stimulation collagen, reaches the object of beauty treatment.Along with the development of micro-processing technology, a kind ofly sting expelling pathogenic factors from the exterior skin but do not injure corium and neural micropin technology was come out, for transdermal administration brings new thinking before the more than ten years.Size pierces through the skin surface (horny layer) of permeability extreme difference at micron-sized micropin dot matrix in the mode of reversible Wicresoft, causes biomacromolecule to be able to the mechanical passage passed through, and does not but produce pain and skin trauma.Thrust preferably to change skin permeation sexuality though conventional metals, glass, siliceous micropin possess, but generally medicine is applied in microneedle surface, drug loading is little, is difficult to reach therapeutic effect.Therefore, there is the empty micropin structure of coating medicine in micropin inside, the medicine of q.s can be made to enter the skin corium of skin by empty micropin.But general microneedle configuration adopts the mode of pressing type mostly, enter skin corium after extruding to medicine, such mode, very easily cause local to infiltrate too much, very few situation is infiltrated in local, affects the absorption of medicine.
Utility model content
In order to solve the problem, the purpose of this utility model is to provide a kind of even pressure microneedle configuration, and what this even pressure microneedle configuration can make medicaments uniformity enters skin corium.
This utility model solves the technical scheme that its technical problem adopts:
This even pressure microneedle configuration comprises base material, described base material is pressed array and is protruded and the hollow microneedles of formation to side, the opposite side of described base material is provided with closed film, moisture self-restraint layer is provided with between described closed film and base material, the root of described hollow microneedles is provided with imbibition swollen material, described base material is provided with the sealing coat of sealing imbibition swollen material, described closed film there is the needle-like portion puncturing described sealing coat, in described hollow microneedles, be provided with the medicament capsule adapted with described imbibition swollen material.
As preferably, described imbibition swollen material is fibroin albumen imbibition swollen material.
As preferably, in described moisture self-restraint layer, be provided with moisture-retaining material.
As preferably, between described imbibition swollen material and medicament capsule, be provided with colloid separate layer.
As preferably, in described colloid separate layer, be provided with the globular solids that diameter is less than hollow microneedles outlet.
The utility model has the advantage of:
Press described closed film, needle-like portion punctures described sealing coat, moisture enters described imbibition swollen material, and imbibition swollen material expands and ejects to skin corium by medicament capsule, during owing to manufacturing, namely the amount of the imbibition swollen material in each hollow microneedles has been determined, therefore, as long as puncture sealing coat, the volume that imbibition swollen material expands is all consistent, uniform thus medicament is injected into skin corium, improves the absorbance of medicament.Meanwhile, adopt fibroin albumen as imbibition swollen material, even if imbibition swollen material is excessive and eject hollow microneedles because of error, reveals in skin corium, because the human compatibility of fibroin albumen, can be absorbed easily by human body, improve the safety used.
Accompanying drawing explanation
Fig. 1 be this even pressure microneedle configuration face generalized section.
Fig. 2 faces generalized section after this even pressure microneedle configuration pressing.
Detailed description of the invention
Below in conjunction with drawings and Examples, this utility model is further illustrated:
In the present embodiment, consult Fig. 1, this even pressure microneedle configuration comprises base material 110, described base material 110 is pressed array and is protruded and the hollow microneedles 100 of formation to side, the opposite side of described base material 110 is provided with closed film 400, moisture self-restraint layer 500 is provided with between described closed film 400 and base material 110, the root of described hollow microneedles 100 is provided with imbibition swollen material 300, described base material 110 is provided with the sealing coat 310 of sealing imbibition swollen material 300, described closed film 400 there is the needle-like portion 410 puncturing described sealing coat, the medicament capsule 10 adapted with described imbibition swollen material 300 is provided with in described hollow microneedles 100.
Above-mentioned even pressure microneedle configuration, described imbibition swollen material 300 is fibroin albumen imbibition swollen material, and fibroin albumen, as imbibition swollen material, even if produce excessive expansion and reveal, also can ensure the safety of human body.
Above-mentioned even pressure microneedle configuration, is provided with moisture-retaining material in described moisture self-restraint layer 500.
Described moisture-retaining material can adopt netted sponge structure, both can keep moisture, can make again closed film 400 resilience after being pressed.
Above-mentioned even pressure microneedle configuration, colloid separate layer 200 is provided with between described imbibition swollen material 300 and medicament capsule 10, described colloid separate layer can adopt medical grade silicone to make, and separate layer can prevent imbibition swollen material 300 to be mixed into medicament capsule 10, and then affects its quality.
Above-mentioned even pressure microneedle configuration, is provided with the globular solids 210 that diameter is less than hollow microneedles outlet in described colloid separate layer 200.
The use principle of the even pressure microneedle configuration in two above-mentioned embodiments:
Consult Fig. 2, press described closed film 400, needle-like portion 410 punctures described sealing coat 310, moisture enters described imbibition swollen material 300, imbibition swollen material 300 expands and ejects to skin corium by medicament capsule 10, because the imbibition swollen material 300 that exists of globular solids 210 is limited in hollow microneedles 100.
Describedly be only preferred embodiment of the present utility model, not in order to limit this utility model, all within spirit of the present utility model and principle, any amendment done, equivalent replacement, improvement etc., all should be included in protection domain of the present utility model.
Claims (5)
1. an even pressure microneedle configuration, comprises base material (110), and described base material (110) is pressed array and protruded and the hollow microneedles (100) of formation to side, it is characterized in that:
The opposite side of described base material (110) is provided with closed film (400), moisture self-restraint layer (500) is provided with between described closed film (400) and base material (110), the root of described hollow microneedles (100) is provided with imbibition swollen material (300), described base material (110) is provided with the sealing coat (310) of sealing imbibition swollen material (300), described closed film (400) there is the needle-like portion (410) puncturing described sealing coat, the medicament capsule (10) adapted with described imbibition swollen material (300) is provided with in described hollow microneedles (100).
2. even pressure microneedle configuration according to claim 1, is characterized in that: described imbibition swollen material (300) is fibroin albumen imbibition swollen material.
3. even pressure microneedle configuration according to claim 1, is characterized in that: be provided with moisture-retaining material in described moisture self-restraint layer (500).
4. even pressure microneedle configuration according to claim 1, is characterized in that: be provided with colloid separate layer (200) between described imbibition swollen material (300) and medicament capsule (10).
5. even pressure microneedle configuration according to claim 4, is characterized in that: be provided with the globular solids (210) that diameter is less than hollow microneedles outlet in described colloid separate layer (200).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520641603.XU CN204910482U (en) | 2015-08-24 | 2015-08-24 | Even microneedle structure that presses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520641603.XU CN204910482U (en) | 2015-08-24 | 2015-08-24 | Even microneedle structure that presses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204910482U true CN204910482U (en) | 2015-12-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520641603.XU Expired - Fee Related CN204910482U (en) | 2015-08-24 | 2015-08-24 | Even microneedle structure that presses |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204910482U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031810A (en) * | 2015-08-24 | 2015-11-11 | 苏州先蚕丝绸生物科技有限公司 | Uniform-pressure microneedle structure |
-
2015
- 2015-08-24 CN CN201520641603.XU patent/CN204910482U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031810A (en) * | 2015-08-24 | 2015-11-11 | 苏州先蚕丝绸生物科技有限公司 | Uniform-pressure microneedle structure |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151230 Termination date: 20160824 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |