CN1939467A - Chinese medicine for preventing and treating fowl colibacillosis - Google Patents
Chinese medicine for preventing and treating fowl colibacillosis Download PDFInfo
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- CN1939467A CN1939467A CN 200610016055 CN200610016055A CN1939467A CN 1939467 A CN1939467 A CN 1939467A CN 200610016055 CN200610016055 CN 200610016055 CN 200610016055 A CN200610016055 A CN 200610016055A CN 1939467 A CN1939467 A CN 1939467A
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Abstract
A veterinary Chinese medicine for treating and prevent colibacillosis of fowls is proportionally prepared from pulsatilla root, coptis root, phellodendron bark and ash bark.
Description
Technical field
The present invention relates to the Chinese medicine medicine of a kind of prevention that is prepared from by Chinese herbal medicine and treatment birds colibacillosis.
Background technology
Fowl colibacillosis is the modal disease of birds, and these diseases are used western medicine mostly, and in taking the process of Western medicine, Western medicine and many bacterial strains are easy to generate drug resistance especially, have influenced the therapeutical effect of medicine, and treatment time is long.And western medicine composition remains in the birds body easily, and the edible back of people produces harm to human body.Existing Chinese medicine is when the treatment disease, and edible with mixing in the feedstuff after the Chinese herbal medicine pulverizing, effective ingredient is difficult to stripping, and treatment time is long.And spice is wasted time and energy, and takes inconvenience, develops a kind of easy to usely, and curative effect is certain, and the product of drug residue free is significant.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provide a kind of and can effectively treat the common colibacillosis of birds, and noresidue in the birds body, the Chinese medicine antibacterial combination that does not develop immunity to drugs, and the abundant effective component extracting of energy, effectively shorten the prevention of treatment time and the Chinese medicine medicine of treatment fowl colibacillosis.
The present invention is achieved through the following technical solutions for achieving the above object: the Chinese medicine medicine of a kind of prevention and treatment fowl colibacillosis, meter by weight, Radix Pulsatillae 10-40 part, Rhizoma Coptidis 5-20 part, Cortex Fraxini 10-40 part, the soak of Cortex Phellodendri 10-30 part after soak with ethanol.
The preparation method of the Chinese medicine medicine of prevention and treatment fowl upper disease comprises the steps
(1) the accurate weighing of medical material of respectively distinguishing the flavor of in the general side decocts 3 times with composition weight 3-10 distilled water doubly earlier, boils 0.5-4 hour at every turn;
(2) cross leaching filtrate, it is 0.9-2.0 that filtrate is concentrated into relative density, is chilled to 40 ℃;
(3) with the ethanol precipitation of 20-95%, left standstill 4-24 hour, filter;
(4) ethanol precipitation of residue reuse 20-95% stirs evenly and leaves standstill 4-24 hour, filters;
(5) merge twice ethanol liquid, and reclaim ethanol to there not being the alcohol flavor, regulate pH value to 5.0, stir evenly, adjusting density is 0.8-1.7;
(6) cold preservation is 72 hours, and packing, sterilization are promptly.
When the present invention treats fowl colibacillosis, get final product according to every birds 1.5-2.5ml/d drinking-water or drip.
Beneficial effect of the present invention:
1, medicine of the present invention is after birds is edible, can reach more than 90% the colibacillary control rate of birds, drug regimen article toxicity is little, and cost is lower, can directly be added in the animal drinking-water, easy to use, can play prevention and therapeutical effect to avian colibacillosis, evident in efficacy, Time of Administration is short, but the anti-adversity ability of enhancing body also simultaneously, noresidue in the body is not developed immunity to drugs.
2, preparation method of the present invention adopts the technology of putting forward with purification, select suitable the extraction and impurity-removing method for use according to the dissolubility of effective monomer in the different medical materials, can make the abundant stripping of effective ingredient of medicine, abundant effective component extracting, can directly contact with pathological tissues, suppress the breeding of antibacterial, heat clearing away, detoxifcation, damp eliminating, but the anti-adversity ability of enhancing body is better brought into play diseases prevention, the resistant effect of medicine.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
1, component drug
(1), the Radix Pulsatillae: Chinese medicine commercially available product; (2), Rhizoma Coptidis: Chinese medicine commercially available product; (3), Cortex Fraxini: Chinese medicine commercially available product; (4), Cortex Phellodendri: Chinese medicine commercially available product; The Radix Pulsatillae in the prescription, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini have inhibitory action to multiple gram negative bacteria, especially escherichia coli, wherein Rhizoma Coptidis is the key medicine of heat clearing and damp drying, and escherichia coli belong to wet disease in the traditional Chinese medical science, simultaneously can also strengthen leukocytic phagocytic function, the antimicrobial while can be improved the resistivity of body.
2, medicine compositing formula is counted by weight,
10 parts of the Radix Pulsatillaes, 5 parts of Rhizoma Coptidis, 10 parts of Cortex Fraxinis, 20 parts of Cortex Phellodendris
3, medicine preparation
(1) the accurate weighing of medical material of respectively distinguishing the flavor of in the general side, the distilled water with 5 times of composition weights decocts 3 times earlier, boils 2 hours at every turn;
(2) cross leaching filtrate, it is 1.4 that filtrate is concentrated into relative density, is chilled to 40 ℃;
(3) with 75% ethanol precipitation, left standstill 12 hours, filter;
(4) ethanol precipitation of residue reuse 95% stirs evenly and leaves standstill 12 hours, filters;
(5) merge twice ethanol liquid, and reclaim ethanol to there not being the alcohol flavor, regulate pH value to 5.0, stir evenly, regulating density is 1.2;
(6) cold preservation is 72 hours, and packing, sterilization promptly get, adorn air-tight bottle and deposit.
The clinical practice test:
1. to the test of chicken colibacillosis:
Application example:
Address: Tianjin Baodi Lee
Kind: AA broiler chicken
Age in days: 17 ages in days
Incidence: chicken group spirit is depressed, and the feather pine disorderly has respiratory symptom individually, and feed intake descends, mortality rate 22% draws yellow-white stench feces, and cuing open inspection visible trachea, bronchus has slight bleeding, the air bag muddiness, pericarditis, perihepatitis, intestinal mucosa comes off, and the foul smelling flavor.Take pathological material of disease to diagnose through test chamber, be judged to avian colibacillosis, this compositions is added in the drinking-water in 2ml/d ratio only, freely drink for fowl, by this dosage logotype 3 days, mortality rate reduced, and feed intake obviously rises, and it is normal that feces recovers, and obtains good result.
1 experiment clinical trial data
1. make a summary:
This laboratory observation is understood the clinical practice situation of the Chinese medicine medicine of prevention and treatment birds colibacillosis to chicken colibacillosis.The Chinese medicine medicine that found that prevention and treatment birds colibacillosis all shows good effect to chicken colibacillosis at high dose, middle dosage and 2.5% pefloxacin mesilate, and difference is remarkable (P＜0.5) not.The Chinese medicine medicine prescription that prevention and treatment birds colibacillosis are described has the obvious suppression effect to escherichia coli.
2. laboratory report: after the attached animal clinical verification experiment.
3. experiment purpose:
Birds escherichia coli, Pullorum Disease Salmonella cause that the disease of chicken is very serious in poultry husbandry.Because most antibacterial drug therapies that adopt, antibacterial easily produces drug resistance, and chemical sproof generation needs to strengthen dose or conversion types of drugs again, has so both increased the cost of treatment, makes that again the drug residue problem is more outstanding.Therefore, seek a kind of has a broad antifungal spectrum, residual little, toxicity is low.We have carried out the animality experiment with the Chinese medicine medicine of prevention and treatment birds colibacillosis, can be and utilize the Chinese herb prevention colibacillosis that foundation is provided.
4. experiment content
4.1 laboratory animal:
4.1.1 kind: with the fast large-scale broiler of AA of a collection of health.
4.1.2 source: provide by the TanJin Agricultural College experimental animal room
4.1.3 body weight: average weight 157g
4.1.4. age in days: 7 ages in days
4.1.5 physical examination: from SPF chicken group
4.1.6 every treated animal number: 100/group
4.1.7 raising condition: raise by normal feeding and management method, and the unified feedstuff of feeding and providing by Tianjin Zhengda Group, each nutrient composition content all meets the feed nutrition standard-required in the feedstuff.
5. experimental design:
Animal subject is equally divided into 5 groups, every group 100, be respectively the Chinese medicine composition low dose group (1.5ml/ only) of prevention and treatment avian colibacillosis, middle dosage group (2.0ml/ only), high dose group (2.5ml/ only), infect not medication group, do not infect not medication group and 2.0% pefloxacin mesilate treatment matched group, with 3 days be a course of treatment, observe medication effect.
6. medicine source:
6.1 be subjected to the reagent thing
6.1.1 title: the Chinese medicine medicine of prevention and treatment birds colibacillosis
6.1.2 research institute: Tianjin City Hynard Animal Pharmaceutical Co., Ltd
6.1.3 lot number: 020212
6.1.4 survey report: after the attached zoopery report
6.1.5 specification: 100ml/ bottle
6.2 reference substance
6.2.1 research institute: technology department of Tianjin life Bioisystech Co., Ltd requires preparation according to Ministry of Agriculture's pefloxacin mesilate soluble powder quality standard
6.2.2 lot number: 20020225
6.2.3 survey report: after the attached animality laboratory report
6.2.4 specification: 50g/ bag
7. morbidity mode:
7.1 artificial onset
7.1.1 the title of strain and source: available from Shandong Agricultural University's fowl diseases institute, make bacterium liquid 1000ml on request, the concentration that records bacterium liquid with the Maxwell turbidimetry is 6 * 10
12CFU/L.
7.1.2 morbidity method: experimental group is pressed 0.8ml/ subcutaneous injection bacterium liquid, and negative control group is pressed 0.8ml/ subcutaneous injection normal saline.
7.2 counteracting toxic substances result: all occur the symptom (negative control group except) identical in 24 hours with colibacillosis.
5 that choose in the positive controls are cutd open inspection and laboratory diagnosis, and its result is a chicken colibacillosis.
7.3 experimental result and analysis
7.3.1 test clinical experiment efficacy result sees the following form
| Group | Experimental chicken number of elements (only) | Cure rate (%) | Effective percentage (%) | Inefficiency (%) | Mortality rate (%) | Experiment has symptom chicken number when finishing | Drug treatment (my god) |
| Negative control group | 100 | - | - | - | - | - | 3 |
| Infect not medication group | 100 | - | - | - | 27％ | 34 | 3 |
| Low dose group (1.5ml/ only) | 100 | 73％ | 82％ | 18％ | 12％ | 23 | 3 |
| Middle dosage group (2.0ml/ only) | 100 | 89％ | 93％ | 7％ | 4％ | 7 | 3 |
| High dose group (2.5ml/ only) | 100 | 92％ | 96％ | 4％ | 3％ | 4 | 3 |
| Pefloxacin treatment matched group | 100 | 88％ | 94％ | 6％ | 6％ | 3 | 3 |
7.3.2 untoward reaction monitoring: according to the animal safety experiment, any untoward reaction do not occur after gavaging continuously with Chinese medicine extraction liquid 2.5ml/ dosage only every day, do not find that through cuing open inspection internal organs have ANOMALOUS VARIATIONS.
8. conclusion: this result of the test shows that the Chinese medicine medicine of prevention and treatment birds colibacillosis is used for the treatment of colibacillosis obvious effects.Curative effect statistics and X
2Assay shows, the therapeutic effect of Chinese medicine composition object height, middle dosage group and the 2% pefloxacin mesilate group of prevention and treatment avian colibacillosis is best, but three's difference not remarkable (P＞0.05).
8.1 clinical use recommended dose: according to Clinical results, can obtain good effect by middle dosage, promptly 2.0ml/ only.
Embodiment 2
1, component medicine
(1), the Radix Pulsatillae: Chinese medicine commercially available product; (2), Rhizoma Coptidis: Chinese medicine commercially available product; (3), Cortex Fraxini: Chinese medicine commercially available product; (4), Cortex Phellodendri: Chinese medicine commercially available product;
2, medicine compositing formula is counted by weight,
Accurately the weighing Radix Pulsatillae is 30 parts, 15 parts of Rhizoma Coptidis, 20 parts of Cortex Fraxinis, 30 parts of Cortex Phellodendris
3, medicine preparation
(1) the accurate weighing of medical material of respectively distinguishing the flavor of in the general side, the distilled water with 5 times of composition weights decocts 3 times earlier, boils 1.5 hours at every turn.
(2) cross leaching filtrate, it is 1.4 that filtrate is concentrated into relative density, is chilled to 40 ℃.
(3) with 75% ethanol precipitation, left standstill 12 hours, filter.
(4) ethanol precipitation of residue reuse 75% stirs evenly and leaves standstill 12 hours, filters.
(5) merge twice ethanol liquid, and reclaim ethanol to there not being the alcohol flavor, regulate pH value to 5.0, stir evenly, regulating density is 1.02.
(6) cold preservation is 72 hours, and packing, sterilization are promptly.
Clinical trial:
1. to the test of chicken colibacillosis:
Application example:
The address: Mare Tranquillitatis, Tianjin honest and just certain
Kind: AA broiler chicken
Age in days: 23 ages in days
Incidence: chicken group spirit is depressed, and the feather pine disorderly has respiratory symptom individually, and feed intake descends, mortality rate 18% draws yellow-white stench feces, and cuing open inspection visible trachea, bronchus has slight bleeding, the air bag muddiness, pericarditis, perihepatitis, intestinal mucosa comes off, and the foul smelling flavor.Take pathological material of disease to diagnose through test chamber, be judged to avian colibacillosis, this compositions is added in the drinking-water in 2ml/d ratio only, freely drink for fowl, by this dosage logotype 3 days, mortality rate reduced, and feed intake obviously rises, and it is normal that feces recovers, and obtains good result.
1 experiment clinical trial data
1. make a summary:
With embodiment 1.
2. laboratory report: after the attached animal clinical verification experiment.
3. experiment purpose:
With embodiment 1.
4. experiment content
4.1 laboratory animal:
4.1.1 kind: with embodiment 1.
4.1.2 source: with embodiment 1
4.1.3 body weight: average weight 1.2kg
4.1.4. age in days: 16 ages in days
4.1.5 physical examination: from SPF chicken group
4.1.6 every treated animal number: 100/group
4.1.7 raising condition: with embodiment 1
5. experimental design:
With embodiment 1
6. medicine source:
6.1 be subjected to the reagent thing
6.1.1 title: the Chinese medicine medicine of prevention and treatment birds colibacillosis
6.1.2 research institute: Tianjin City Hynard Animal Pharmaceutical Co., Ltd
6.1.3 lot number: 020213
6.1.4 survey report: after the attached zoopery report
6.1.5 specification: 100ml/ bottle
6.2 reference substance
6.2.1 research institute: with embodiment 1
6.2.2 lot number: with embodiment 1
6.2.3 survey report: with embodiment 1
6.2.4 specification: 50g/ bag
7. morbidity mode:
7.1 artificial onset
7.1.1 the title of strain and source: with embodiment 1.
7.1.2 morbidity method: with embodiment 1
7.2 counteracting toxic substances result: all occur the symptom (negative control group except) identical in 24 hours with colibacillosis.
5 that choose in the positive controls are cutd open inspection and laboratory diagnosis, and its result is a chicken colibacillosis.
7.3 experimental result and analysis
7.3.1 test clinical experiment efficacy result sees Table
| Group | Experimental chicken number of elements (only) | Cure rate (%) | Effective percentage (%) | Inefficiency (%) | Mortality rate (%) | Experiment has symptom chicken number when finishing | Drug treatment (my god) |
| Negative control group | 100 | - | - | - | - | - | 3 |
| Infect not medication group | 100 | - | - | - | 22％ | 25 | 3 |
| Low dose group (1.5ml/ only) | 100 | 70％ | 81％ | 19％ | 15％ | 13 | 3 |
| Middle dosage group (2.0ml/ only) | 100 | 87％ | 90％ | 10％ | 4％ | 4 | 3 |
| High dose group (2.5ml/ only) | 100 | 93％ | 95％ | 5％ | 2％ | 4 | 3 |
| Pefloxacin treatment matched group | 100 | 88％ | 94％ | 6％ | 6％ | 3 | 3 |
7.3.2 untoward reaction monitoring: with embodiment 1.
8. conclusion: with embodiment 1.
8.1 clinical use recommended dose: with embodiment 1
Embodiment 3
1, component medicine
(1), the Radix Pulsatillae: Chinese medicine commercially available product; (2), Rhizoma Coptidis: Chinese medicine commercially available product; (3), Cortex Fraxini: Chinese medicine commercially available product; (4), Cortex Phellodendri: Chinese medicine commercially available product;
2, medicine compositing formula is counted by weight,
40 parts of the Radix Pulsatillaes, 20 parts of Rhizoma Coptidis, 40 parts of Cortex Fraxinis, Cortex Phellodendri 10
3, medicine preparation
(1) the accurate weighing of medical material of respectively distinguishing the flavor of in the general side, the distilled water with 5 times of composition weights decocts 3 times earlier, boils 1.5 hours at every turn.
(2) cross leaching filtrate, it is 1.4 that filtrate is concentrated into relative density, is chilled to 40 ℃.
(3) with 75% ethanol precipitation, left standstill 12 hours, filter.
(4) ethanol precipitation of residue reuse 75% stirs evenly and leaves standstill 12 hours, filters.
(5) merge twice ethanol liquid, and reclaim ethanol to there not being the alcohol flavor, regulate pH value to 5.0, stir evenly, regulating density is 1.02.
(6) cold preservation is 72 hours, and packing, sterilization are promptly.
Clinical trial:
1. to the test of chicken colibacillosis:
Application example:
Address: Shandong Province Pingdu Zhang
Kind: AA broiler chicken
Age in days: 12 ages in days
Incidence: chicken group spirit is depressed, and the feather pine disorderly has respiratory symptom individually, and feed intake descends, mortality rate 23% draws yellow-white stench feces, and cuing open inspection visible trachea, bronchus has slight bleeding, the air bag muddiness, pericarditis, perihepatitis, intestinal mucosa comes off, and the foul smelling flavor.Take pathological material of disease to diagnose through test chamber, be judged to avian colibacillosis, this compositions is added in the drinking-water in 2ml/d ratio only, freely drink for fowl, by this dosage logotype 3 days, mortality rate reduced, and feed intake obviously rises, and it is normal that feces recovers,
Obtain good result.
1 experiment clinical trial data
1. make a summary:
With embodiment 1.
2. laboratory report: after the attached animal clinical verification experiment.
3. experiment purpose:
With embodiment 1.
4. experiment content
4.1 laboratory animal:
4.1.1 kind: with embodiment 1.
4.1.2 source: with embodiment 1
4.1.3 body weight: average weight 1.7kg
4.1.4. age in days: 32 ages in days
4.1.5 physical examination: from SPF chicken group
4.1.6 every treated animal number: 100/group
4.1.7 raising condition: with embodiment 1
5. experimental design:
With embodiment 1
6. medicine source:
6.1 be subjected to the reagent thing
6.1.1 title: the Chinese medicine medicine of prevention and treatment birds colibacillosis
6.1.2 research institute: Tianjin City Hynard Animal Pharmaceutical Co., Ltd
6.1.3 lot number: 020215
6.1.4 survey report: slightly
6.1.5 specification: 100ml/ bottle
6.2 reference substance
6.2.1 research institute: with embodiment 1
6.2.2 lot number: with embodiment 1
6.2.3 survey report: with embodiment 1
6.2.4 specification: 50g/ bag
7. morbidity mode:
7.1 artificial onset
7.1.1 the title of strain and source: with embodiment 1.
7.1.2 morbidity method: with embodiment 1
7.2 counteracting toxic substances result: all occur the symptom (negative control group except) identical in 24 hours with colibacillosis.
5 that choose in the positive controls are cutd open inspection and laboratory diagnosis, and its result is a chicken colibacillosis.
7.3 experimental result and analysis
7.3.1 test clinical experiment efficacy result sees Table
| Group | Experimental chicken number of elements (only) | Cure rate (%) | Effective percentage (%) | Inefficiency (%) | Mortality rate (%) | Experiment has symptom chicken number when finishing | Drug treatment (my god) |
| Negative control group | 100 | - | - | - | - | - | 3 |
| Infect not medication group | 100 | - | - | - | 22％ | 25 | 3 |
| Low dose group (1.5ml/ only) | 100 | 73％ | 84％ | 16％ | 12％ | 15 | 3 |
| Middle dosage group (2.0ml/ only) | 100 | 89％ | 93％ | 7％ | 3％ | 5 | 3 |
| High dose group (2.5ml/ only) | 100 | 91％ | 93％ | 7％ | 2％ | 4 | 3 |
| Pefloxacin treatment matched group | 100 | 88％ | 94％ | 6％ | 3％ | 4 | 3 |
7.3.2 untoward reaction monitoring: with embodiment 1.
8. conclusion: with embodiment 1.
The embodiment explanation, but the present invention treats the anti-adversity ability of the Chinese medicine medicine enhancing body of fowl colibacillosis, better brings into play diseases prevention, the resistant effect of medicine.
Claims (1)
1. a Chinese medicine medicine that prevents and treat fowl colibacillosis is characterized in that: count Radix Pulsatillae 10-40 part, Rhizoma Coptidis 5-20 part, Cortex Fraxini 10-40 part, the soak of Cortex Phellodendri 10-30 part after soak with ethanol by weight.
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| CN 200610016055 CN1939467A (en) | 2006-09-28 | 2006-09-28 | Chinese medicine for preventing and treating fowl colibacillosis |
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| CN102028795A (en) * | 2010-12-24 | 2011-04-27 | 北京大北农科技集团股份有限公司 | Chinese pulsatilla root granules for preventing and treating livestock and poultry bacterial diseases and preparation method and premix thereof |
| CN102526302A (en) * | 2011-12-31 | 2012-07-04 | 郑州后羿制药有限公司 | Chinese medicinal micro-ecological preparation for inhibiting piglet bacterial dysentery and preparation method thereof |
| CN102688305A (en) * | 2012-06-11 | 2012-09-26 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102988552A (en) * | 2012-11-02 | 2013-03-27 | 青岛康地恩药业股份有限公司 | Traditional Chinese medicine compound radix pulsatillae particle for treating chicken colibacillosis and preparation method and application thereof |
| CN104208294A (en) * | 2013-09-29 | 2014-12-17 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating piglet yellow-white dysentery and preparation method thereof |
| CN104257826A (en) * | 2014-09-24 | 2015-01-07 | 河南亚卫动物药业有限公司 | Traditional Chinese medicine pycnonotus sinensis fermented granule for livestock and poultry and preparation method of traditional Chinese medicine pycnonotus sinensis fermented granule |
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| CN112168888A (en) * | 2020-11-12 | 2021-01-05 | 邓云波 | Pure traditional Chinese medicine composition powder for treating bacterial and viral intestinal diseases of livestock and poultry |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102028795A (en) * | 2010-12-24 | 2011-04-27 | 北京大北农科技集团股份有限公司 | Chinese pulsatilla root granules for preventing and treating livestock and poultry bacterial diseases and preparation method and premix thereof |
| CN102526302A (en) * | 2011-12-31 | 2012-07-04 | 郑州后羿制药有限公司 | Chinese medicinal micro-ecological preparation for inhibiting piglet bacterial dysentery and preparation method thereof |
| CN102688305A (en) * | 2012-06-11 | 2012-09-26 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102688305B (en) * | 2012-06-11 | 2013-12-25 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102988552A (en) * | 2012-11-02 | 2013-03-27 | 青岛康地恩药业股份有限公司 | Traditional Chinese medicine compound radix pulsatillae particle for treating chicken colibacillosis and preparation method and application thereof |
| CN104208294A (en) * | 2013-09-29 | 2014-12-17 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating piglet yellow-white dysentery and preparation method thereof |
| CN104208294B (en) * | 2013-09-29 | 2018-01-16 | 河南后羿实业集团有限公司 | It is a kind of to be used to treat Chinese medicine composition of piglet yellow-white dysentery and preparation method thereof |
| CN104257826A (en) * | 2014-09-24 | 2015-01-07 | 河南亚卫动物药业有限公司 | Traditional Chinese medicine pycnonotus sinensis fermented granule for livestock and poultry and preparation method of traditional Chinese medicine pycnonotus sinensis fermented granule |
| CN107184785A (en) * | 2017-05-04 | 2017-09-22 | 河北工程大学 | A kind of medicine for preventing and treating rabbit E.coli disease |
| CN112168888A (en) * | 2020-11-12 | 2021-01-05 | 邓云波 | Pure traditional Chinese medicine composition powder for treating bacterial and viral intestinal diseases of livestock and poultry |
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