CN102688305A - Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof - Google Patents
Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof Download PDFInfo
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- 201000010099 disease Diseases 0.000 title abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 5
- 241000588724 Escherichia coli Species 0.000 title abstract description 4
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 9
- 239000004375 Dextrin Substances 0.000 claims description 9
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- 229910000831 Steel Inorganic materials 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
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- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 description 2
- QNHQEUFMIKRNTB-UHFFFAOYSA-N aesculetin Natural products C1CC(=O)OC2=C1C=C(O)C(O)=C2 QNHQEUFMIKRNTB-UHFFFAOYSA-N 0.000 description 2
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- WMPXPUYPYQKQCX-UHFFFAOYSA-N Sulfamonomethoxine Chemical compound C1=NC(OC)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 WMPXPUYPYQKQCX-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a Chinese medicine granule preparation for controlling livestock escherichia coli diseases and a preparation method thereof. The preparation method comprises the following steps of: extracting compound Chinese medicine effective extracts consisting of six Chinese traditional medicines (windflower, ash barks, coptis, elecampane, radix paeoniae alba and akebiaquinata); concentrating to 2g of crude drug per mL based on a crude drug concentration; while stirring, dropwise adding the concentrated effective extract to proper auxiliary materials according to the condition that a ratio of liquid medicine volume (mL) to auxiliary material mass (g) is 1:5; and finally adding adhesives to prepare granules; wherein the mass ratio of windflower, ash barks, coptis, elecampane, radix paeoniae alba to akebiaquinata in a compound formulation is (3-5):(3-5):(3-5):(1-2):(3-5):(1-3). When antibiotics are unavailable, the Chinese medicine granule preparation can be fed to livestock by mixing water or adding materials and has obvious effects of controlling the livestock escherichia coli diseases. The preparation is simple and convenient to use, can be used for solving the problems of inconvenience for use of a Chinese herbal medicine preparation and antibiotic residues of animal products and has better feeding benefits.
Description
Technical field
The present invention relates to Chinese medicine granules of a kind of functional living being feed additive and preparation method thereof, be specifically related to a kind of biology feed additive Chinese medicine granules with control poultry colibacillosis.
Background technology
Medicated feed additive has improved productivity ratio and has raised economic benefit because it has effects such as the growth of animals or poultry of promotion and prevent disease, in China's livestock and poultry breeding industry, plays an important role.Yet along with the life-time service of medicated feed additive, especially problems such as serious drug resistance, drug residue, environmental pollution have appearred in antibiotic, the chemical synthetic drug abuse in feedstuff.This has not only reduced the quality of livestock products, also can have influence on human health and ecological balance through biological chain.Along with the paces of international marketization after the China joined WTO are accelerated; And people are to the raising of quality of life requirement; Develop nuisanceless animal husbandry; Producing green livestock products has become the top priority of herding authorities of the Chinese government, seek to substitute antibiotic and chemicals green, safety, the nuisanceless green feed additive becomes the task of top priority of quickening China poultry industry sustainable development efficiently.
Chinese medicine has antibiotic, has the dual function that improves and regulate fuselage state concurrently, both can improve fertility performance and prophylaxis effect, and characteristics such as low-residual, pollution-free, difficult generation drug resistance are arranged again, has become the focus of domestic and international novel green feed additive research.China's Chinese herbal medicine resource is abundant, Chinese medicine extract is used as feed additive have antibiotic feed additive incomparable advantage and development prospect.Yet the extensive use of the Chinese herbal medicine for animals of China also exists many problems in the application of tradition Chinese medicine for animals, and is big like the volume of herbal mixture, and effective ingredient is low and unstable, comprehensive therapeutic effect instability etc.How to utilize now novel technological means with tradition Chinese medicine for animals change that curative effect height, dosage are little into, convenient transportation, ease in use, uniform specification and the clear and definite new formulation of quality standard be a major issue improving modern Chinese medicine.
Summary of the invention
In view of above-mentioned weak point; The present invention is through a large amount of research and practice; A kind of herbal mixture granule with anti-poultry colibacillosis is provided, and this granule can directly add in the feedstuff as feed additive simultaneously, also can directly mix in livestock and fowl drinking water; Make it in abundant, convenient and simple route of administration and when not influencing drug effect, also can improve its bioavailability.
In order to achieve the above object, the present invention has adopted following technical scheme:
A kind of Chinese medicine preparation of preventing and treating the poultry colibacillosis extracts the herbal mixture effective extract of being made up of the Radix Pulsatillae, Cortex Fraxini, Rhizoma Coptidis, the Radix Aucklandiae, the Radix Paeoniae Alba, Caulis Akebiae 6 flavor Chinese medicines, is concentrated into 2g crude drug mL
-1(pressing crude drug concentration calculates) under agitation dropwise adds the effective extract after concentrating in the proper auxiliary materials according to the ratio of 1: 5 (medicine liquid volume mL/ adjuvant quality g), adds binding agent at last and processes granule; The Radix Pulsatillae, Cortex Fraxini, Rhizoma Coptidis, the Radix Aucklandiae, the Radix Paeoniae Alba, Caulis Akebiae mass ratio in compound recipe is 3～5: 3～5: 3～5: 1～2: 3～5: 1～3.
Described Chinese medicine preparation; Described effective extract, its method for distilling is: the herbal mixture that the Radix Pulsatillae, Cortex Fraxini, Rhizoma Coptidis, the Radix Aucklandiae, the Radix Paeoniae Alba, Caulis Akebiae are formed is ground into behind the powder 50-70% (V/V) ethanol of doubly measuring (volume mass than) with 6-10, reflux, extract, 1-3 time; Each 0.5-1.5h; Merge extractive liquid,, concentrating under reduced pressure then obtains the effective extract of herbal mixture.
Described Chinese medicine preparation, described adjuvant are that soluble starch, alpha-lactose, dextrin are according to 3: 1: 1 mixture of mass ratio; Binding agent is 0.3% sodium carboxymethyl cellulose.
The method for preparing of described Chinese medicine preparation, concrete steps are following: the herbal mixture effective extract under agitation proportionally dropwise adds in the adjuvant, adds binding agent then and processes soft material; The soft material that makes is crossed a steel sieve series become wet granular; Place 55 ℃ of electric heating constant temperature air dry ovens dry; Adding magnesium oxide in the dried granules, crossing sieve behind the mixing No. one, will put into sieve No. five through the granule of a sieve; Collect the granule on the sieve No. five, obtain a kind of Chinese medicine granules of preventing and treating the poultry colibacillosis.
Described method, the method for preparing of said adjuvant is: according to soluble starch: alpha-lactose: the mass ratio of dextrin is to take by weighing soluble starch, alpha-lactose, dextrin, mix homogeneously at 3: 1: 1.
Described method; The method for preparing of said herbal mixture effective extract is: is 3～5: 3～5 with the Radix Pulsatillae, Cortex Fraxini, Rhizoma Coptidis, the Radix Aucklandiae, the Radix Paeoniae Alba, Caulis Akebiae according to mass ratio: behind the compound medicine raw material pulverizing powdered of 3～5: 1～2: 3～5: 1～3 composition; Doubly measure 50-70% (V/V) ethanol of (volume mass ratio) with 6-10; Reflux, extract, 3 times, each 0.5h carries out condensing reflux and extracts merge extractive liquid; Concentrating under reduced pressure is 2g crude drug/mL up to calculating solution concentration with crude drug concentration, obtains the effective extract of compound medicine.
The application of the Chinese medicine preparation of described control poultry colibacillosis in preparation functional living being feed additive.
Granule among the present invention is mainly through routine examinations such as granularity, outward appearance, moisture, meltings and utilize reversed-phase high-performance liquid chromatography that the content of aesculetin in the granule and berberine hydrochloride is measured and set up quality standard.Quality standard is: the granule outward appearance is dry, uniform particles, and color and luster is consistent, and the no moisture absorption is softened, caking, deliquescence etc.; Clarity short time in regulation hot water can dissolve, and the no obvious bulk foreign body in dissolving back, and muddiness is arranged slightly; Water content remains in 3.70%～3.90% scope, closes the regulation of symbol pharmacopeia to Chinese medicine granules; The content of aesculetin and berberine hydrochloride is respectively 0.36mg and 2.90mg in average every 1g granule.
The present invention shows through pharmacodynamic study, for having therapeutical effect because of the caused disease of poultry escherichia coli.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is elaborated.
Embodiment 1
The compound medicine that Radix Pulsatillae 20g, Cortex Fraxini 20g, Rhizoma Coptidis 20g, Radix Aucklandiae 8g, Radix Paeoniae Alba 20g, Caulis Akebiae 12g are formed is ground into behind the powder with 10 times of amount (volume mass ratios; 60% ethanol ml number: 60% ethanol herbal mixture powder g number=10: 1); Reflux, extract, 3 times, each 0.5h; Merge extractive liquid; Concentrating under reduced pressure is to the effective extract of 2g crude drug/mL then; Under agitation dropwise add mass ratio then and be in the adjuvant of 1: 5 (medicine liquid volume in mL: the adjuvant quality is in g), wherein adjuvant is a soluble starch: alpha-lactose: the mass ratio of dextrin is 3: 1: 1 homogeneous mixtures; Add 3-5 then and drip mass percent concentration 0.3% sodium carboxymethyl cellulose solution and mix homogeneously, process soft material preferably; The soft material that makes is put into sieve of rustless steel sieve, let the soft material granulating process wet granular through a sieve aperture; The wet granular that makes paved puts into porcelain dish, and in 55 ℃ of electric heating constant temperature air dry ovens dry 15min, process dried granule; (magnesium oxide powder plays a part lubricated in dried granules, to add the 1.5g magnesium oxide powder; Can regulate voluntarily); Putting into a sieve behind the mixing sieves; To continue to put into No. five through the granule of a sieve and sieve, collect the granule on the sieve No. five, obtain a kind of Chinese medicine granules of preventing and treating the poultry colibacillosis.
Embodiment 2
The compound medicine that Radix Pulsatillae 10g, Cortex Fraxini 10g, Rhizoma Coptidis 10g, Radix Aucklandiae 4g, Radix Paeoniae Alba 10g, Caulis Akebiae 6g are formed is ground into behind the powder 50% (V/V) ethanol with 6 times of amounts (volume mass than), reflux, extract, 1 time, 1.5h at every turn; Merge extractive liquid; Concentrating under reduced pressure is to the effective extract of 2g crude drug/mL then; (medicine liquid volume mL: in adjuvant adjuvant quality g), wherein adjuvant is a soluble starch: alpha-lactose: the mass ratio of dextrin is 6: 1: 4 homogeneous mixtures under agitation dropwise to add mass ratio then and be 1: 5; Add 3-5 then and drip mass percent concentration 0.1% sodium carboxymethyl cellulose solution and mix homogeneously, process soft material; The soft material that makes is put into sieve of rustless steel sieve, let the soft material granulating process wet granular through a sieve aperture; The wet granular of system is paved and is put into porcelain dish, and in 55 ℃ of electric heating constant temperature air dry ovens dry 15min, process dried granule; The magnesium oxide that in dried granules, adds 1g; Put into a sieve behind the mixing and sieve, make granule pass through sieve No. one, will continue to put into No. five through the granule of a sieve and sieve; Collect the granule on the sieve No. five, obtain a kind of Chinese medicine granules of preventing and treating the poultry colibacillosis.
Embodiment 3
The compound medicine that Radix Pulsatillae 25g, Cortex Fraxini 25g, Rhizoma Coptidis 25g, Radix Aucklandiae 10g, Radix Paeoniae Alba 25g, Caulis Akebiae 15g are formed is ground into behind the powder 70% (V/V) ethanol with 8 times of amounts (volume mass than), reflux, extract, 2 times, 1h at every turn; Merge extractive liquid; Concentrating under reduced pressure is to the effective extract of 2g crude drug/mL then; (medicine liquid volume mL: in adjuvant adjuvant quality g), wherein adjuvant is a soluble starch: alpha-lactose: the mass ratio of dextrin is 3: 2: 2 homogeneous mixtures under agitation dropwise to add mass ratio then and be 1: 5; Add 3-5 then and drip mass percent concentration 0.1% sodium carboxymethyl cellulose solution and mix homogeneously, process soft material; The soft material that makes is put into sieve of rustless steel sieve, let the soft material granulating process wet granular through a sieve aperture; The wet granular of system is paved and is put into porcelain dish, and in 55 ℃ of electric heating constant temperature air dry ovens dry 15min, process dried granule; Adding the 2g magnesium oxide in the dried granules, put into a sieve behind the mixing and sieve, will continue to put into No. five through the granule of a sieve and sieve, collect the granule on the sieve No. five, obtain a kind of Chinese medicine granules of preventing and treating the poultry colibacillosis.
Embodiment 4
The Chinese medicine granules of control avian colibacillosis is to the therapeutical effect of chicken colibacillosis
The chickling of 150 7 age in days ehec infections is divided into 5 groups at random and is designated as I, II, III, IV, V group respectively.The I group be low dose group (2%, Chinese medicine granules quality: feeding quality); The II group be middle dose groups (4%, Chinese medicine granules quality: feeding quality); The III group be high dose group (8%, Chinese medicine granules quality: feeding quality); The IV group is 1% sulfamonomethoxine matched group; The V group is blank group (not treating group), 30 every group and carry out the continuous 7 days treatment of feeding.The result is following: the V group is that blank control group (not treating group) inefficiency is 76.7%, and the IV group is a sulfonamide treatment group inefficiency 43.3%, and low dosage of the present invention, middle dosage, high dose Chinese medicine granules treatment group inefficiency are respectively 56.7%, 40% and 36.7%.The above results shows that herbal mixture granule of the present invention has the good curing effect for chicken colibacillosis; Its curative effect is with methoxy therapeutic equivalence between chemical antimicrobial drug sulfanilamide; But the drawback that it does not have the drug resistance and the drug residue of chemical antimicrobial drug is that the potential drug selection preferably of green non-poisonous compound of Chinese medicine chicken colibacillosis is used in current promotion.
Should be understood that, concerning those of ordinary skills, can improve or conversion, and all these improvement and conversion all should belong to the protection domain of accompanying claims of the present invention according to above-mentioned explanation.
Claims (7)
1. a Chinese medicine preparation of preventing and treating the poultry colibacillosis is characterized in that: extract the herbal mixture effective extract of being made up of the Radix Pulsatillae, Cortex Fraxini, Rhizoma Coptidis, the Radix Aucklandiae, the Radix Paeoniae Alba, Caulis Akebiae 6 flavor Chinese medicines, be concentrated into 2g crude drug mL
-1(pressing crude drug concentration calculates) under agitation dropwise adds the effective extract after concentrating in the proper auxiliary materials according to the ratio of 1: 5 (medicine liquid volume mL/ adjuvant quality g), adds binding agent at last and processes granule; The Radix Pulsatillae, Cortex Fraxini, Rhizoma Coptidis, the Radix Aucklandiae, the Radix Paeoniae Alba, Caulis Akebiae mass ratio in compound recipe is 3～5: 3～5: 3～5: 1～2: 3～5: 1～3.
2. by the described Chinese medicine preparation of claim 1; It is characterized in that: described effective extract, its method for distilling is: the herbal mixture that the Radix Pulsatillae, Cortex Fraxini, Rhizoma Coptidis, the Radix Aucklandiae, the Radix Paeoniae Alba, Caulis Akebiae are formed is ground into behind the powder 50-70% (V/V) ethanol of doubly measuring (volume mass than) with 6-10, reflux, extract, 1-3 time; Each 0.5-1.5h; Merge extractive liquid,, concentrating under reduced pressure then obtains the effective extract of herbal mixture.
3. by the described Chinese medicine preparation of claim 1, it is characterized in that: described adjuvant is that soluble starch, alpha-lactose, dextrin are according to 3: 1: 1 mixture of mass ratio; Binding agent is 0.3% sodium carboxymethyl cellulose.
4. the method for preparing of the arbitrary described Chinese medicine preparation of claim 1 to 3 is characterized in that, concrete steps are following: the herbal mixture effective extract under agitation proportionally dropwise adds in the adjuvant, adds binding agent then and processes soft material; The soft material that makes is crossed a steel sieve series become wet granular; Place 55 ℃ of electric heating constant temperature air dry ovens dry; Adding magnesium oxide in the dried granules, crossing sieve behind the mixing No. one, will put into sieve No. five through the granule of a sieve; Collect the granule on the sieve No. five, obtain a kind of Chinese medicine granules of preventing and treating the poultry colibacillosis.
5. the described method of claim 4, it is characterized in that: the method for preparing of said adjuvant is: according to soluble starch: alpha-lactose: the mass ratio of dextrin is to take by weighing soluble starch, alpha-lactose, dextrin, mix homogeneously at 3: 1: 1.
6. the described method of claim 4; It is characterized in that: the method for preparing of said herbal mixture effective extract is: is 3～5: 3～5 with the Radix Pulsatillae, Cortex Fraxini, Rhizoma Coptidis, the Radix Aucklandiae, the Radix Paeoniae Alba, Caulis Akebiae according to mass ratio: behind the compound medicine raw material pulverizing powdered of 3～5: 1～2: 3～5: 1～3 composition; Doubly measure 50-70% (V/V) ethanol of (volume mass ratio) with 6-10; Reflux, extract, 3 times, each 0.5h carries out condensing reflux and extracts merge extractive liquid; Concentrating under reduced pressure is 2g crude drug/mL up to calculating solution concentration with crude drug concentration, obtains the effective extract of compound medicine.
7. the application of Chinese medicine preparation in preparation functional living being feed additive of the arbitrary described control poultry colibacillosis of claim 1 to 3.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800300A (en) * | 2015-05-14 | 2015-07-29 | 四川铁骑力士实业有限公司 | Traditional Chinese medicine composition for preventing porcine reproductive and respiratory syndrome and preparation method thereof |
| CN106728234A (en) * | 2016-12-29 | 2017-05-31 | 四川农业大学 | A kind of Chinese medicine preparation for preventing and treating eggs crack detection disease and preparation method thereof |
| CN107184785A (en) * | 2017-05-04 | 2017-09-22 | 河北工程大学 | A kind of medicine for preventing and treating rabbit E.coli disease |
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| CN1939467A (en) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | Chinese medicine for preventing and treating fowl colibacillosis |
| US20080124405A1 (en) * | 2006-06-08 | 2008-05-29 | Chih-Hsuing Lin | Composition for Prophylaxis or Treatment of Urinary System Infection and Method Thereof |
| WO2009095993A1 (en) * | 2008-01-29 | 2009-08-06 | Nakamori Pharmaceutical Co., Ltd. | Medicinal composition |
| CN101972392A (en) * | 2010-08-25 | 2011-02-16 | 天津生机集团股份有限公司 | Chinese medicinal composition for treating chicken colibacillosis and preparation method thereof |
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| JP2003113010A (en) * | 2001-10-09 | 2003-04-18 | Kankyo Science Kk | Antimicrobial deodorant |
| CN1879736A (en) * | 2006-05-16 | 2006-12-20 | 天津生机集团有限公司 | Antibacterial Chinese medicinal composition for birds and preparation method thereof |
| US20080124405A1 (en) * | 2006-06-08 | 2008-05-29 | Chih-Hsuing Lin | Composition for Prophylaxis or Treatment of Urinary System Infection and Method Thereof |
| CN1939467A (en) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | Chinese medicine for preventing and treating fowl colibacillosis |
| WO2009095993A1 (en) * | 2008-01-29 | 2009-08-06 | Nakamori Pharmaceutical Co., Ltd. | Medicinal composition |
| CN101972392A (en) * | 2010-08-25 | 2011-02-16 | 天津生机集团股份有限公司 | Chinese medicinal composition for treating chicken colibacillosis and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800300A (en) * | 2015-05-14 | 2015-07-29 | 四川铁骑力士实业有限公司 | Traditional Chinese medicine composition for preventing porcine reproductive and respiratory syndrome and preparation method thereof |
| CN104800300B (en) * | 2015-05-14 | 2017-09-19 | 四川铁骑力士实业有限公司 | It is a kind of to prevent Chinese medicine composition of pig blue-ear disease and preparation method thereof |
| CN106728234A (en) * | 2016-12-29 | 2017-05-31 | 四川农业大学 | A kind of Chinese medicine preparation for preventing and treating eggs crack detection disease and preparation method thereof |
| CN106728234B (en) * | 2016-12-29 | 2020-08-07 | 四川农业大学 | A kind of traditional Chinese medicine preparation for preventing and treating poultry pasteurellosis and preparation method thereof |
| CN107184785A (en) * | 2017-05-04 | 2017-09-22 | 河北工程大学 | A kind of medicine for preventing and treating rabbit E.coli disease |
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| CN102688305B (en) | 2013-12-25 |
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