CN1788568A - Quick-effective iodine disinfectant and production method thereof - Google Patents
Quick-effective iodine disinfectant and production method thereof Download PDFInfo
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- CN1788568A CN1788568A CN 200510130839 CN200510130839A CN1788568A CN 1788568 A CN1788568 A CN 1788568A CN 200510130839 CN200510130839 CN 200510130839 CN 200510130839 A CN200510130839 A CN 200510130839A CN 1788568 A CN1788568 A CN 1788568A
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Abstract
The present invention relates to disinfectant, and is especially one kind of quick acting iodine disinfectant, named as Weihuakangfudian, and its production process. The iodine disinfectant is compounded with iodine, potassium iodide, polyvinyl pyrrolidone, sodium fatty alcohol polyoxyethylene ether sulfate and cocoalcohol diethanol amide in the weight ratio of 1 (1~3) to (4~7) to (0.2~0.5) to (0.2~0.5). It is nut brown transparent liquid and may be mixed with water in different ratio to form stable water solution. It has broad germicidal spectrum of killing various kinds of bacteria, viruses, mildew, etc. as well as detergency. It has high disinfection effect, simple production process, low production cost, wide application range and convenient use.
Description
Technical field
The present invention relates to a kind of disinfectant, relate in particular to a kind of quick-effective iodine disinfectant and production method thereof.
Background technology
At present, the disinfectant kind of using in the hygiene medical treatment industry is a lot, can be divided into non-living body tissue and biological tissue and use two big classes, it is undesirable that these existing disinfectants exist Disinfection Effect, the scope of application is single, excitant is big, complex manufacturing, very strict to the requirement of working condition, and have xanthochromia to be difficult for disappearing to take off; And be applied to respectively can not be general mutually between the disinfectant of non-living body tissue and biological tissue.Even if the disinfectant of import is arranged, also because the prescription of its composition and the difference of production method make the performance of disinfectant and range of application also different, and very strict for environment for use and conditional request, price is also expensive, is not easy to generally promote the use of.The inventor is in the patent of invention of application on October 16th, 1999, and the patent No. is 95111245.7, and it is more single just to exist the scope of application, and complex manufacturing is strict to the requirement of working condition, the defective that production cost is high.
Summary of the invention
The purpose of this invention is to provide that a kind of Disinfection Effect is remarkable, production technology is simple, production cost is low, applied range, and a kind of quick-effective iodine disinfectant and production method thereof very easy to use, its commodity are called " Wei Huakangfu iodine ".
The object of the present invention is achieved like this:
A kind of quick-effective iodine disinfectant, it is to be formed than preparation by following raw materials by weight portion:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: (1~3): (4~7): (0.2~0.5): (0.2~0.5).
The raw material weight umber proportioning of described quick-effective iodine disinfectant is:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 1: 4: 0.2: 0.2;
The raw material weight umber proportioning of described quick-effective iodine disinfectant is:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 2: 5: 0.3: 0.3;
The raw material weight umber proportioning of described quick-effective iodine disinfectant is:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 3: 7: 0.5: 0.5.
A kind of production method of quick-effective iodine disinfectant is:
(1) gets iodine by the described ratio of weight and number of claim 1, be ground into powdery, and then add potassium iodide, continue to grind to form powdery, add polyvinylpyrrolidone at last, continue to grind mixing, get A;
(2) under the normal temperature state, above-mentioned powder raw material A to be inserted in the retort of sealing that temperature is a room temperature, Solid complexing 12~24 hours stirs 2~3 times therebetween;
(3) after the arrival of Solid complexing time, add distilled water, the limit edged stirs;
(4) add distilled water after, making its available iodine concentration is 0.2~2%, adding distil water does not have any particle or suspension floccule after be dissolved into the shinny transparency liquid of sepia in 6~12 hours fully;
(5) add sodium sulfate of polyethenoxy ether of fatty alcohol and coconut fatty alcohols diglycollic amide by the described ratio of weight and number of claim 1, stir at normal temperatures, carry out packing by the Packing Unit size, promptly.
Quick-effective iodine disinfectant of the present invention has following characteristics:
1, non-ionic surface active agent---polyvinylpyrrolidone can be used as the carrier and the cosolvent of iodine, especially also added a certain amount of potassium iodide in this product, also play the cosolvent effect, both have increased the dissolving of iodine, have guaranteed to rise in this product the available iodine concentration of absolute bactericidal action.
2, non-ionic surface active agent---polyvinylpyrrolidone can increase the penetration capacity of iodine disinfectant sterilization greatly; Because non-ionic surface active agent high adsorption capacity, when contacting with pathogenic microorganisms, non-ionic surface active agent promptly is adsorbed on around the thalline, and the iodine that is dissolved in the non-ionic surface active agent is constantly discharged, the halogenation mycoprotein makes mycoprotein sex change, disintegration and death.
3, because non-ionic surface active agent has the washing dirt-removing power, and reduce the consumption of available iodine in the disinfectant, improve sterilizing ability indirectly.Be that this product is a decontaminant, washing decontamination, both effects of disinfection are had both.
4, owing to carrier and the cosolvent of making iodine with non-ionic surface active agent, this also greatly reduces the corrosion spread effect of iodine, therefore can be used for the sterilization of body tissues such as skin, mucous membrane, thereby has increased the range of application of this product.
5, because this product is to form with iodine and non-ionic surface active agent complexing, and xanthochromia is wash-out very easily, need not to take off iodine, in use, not only reduced program but also the laborsaving province's raw material that saves time with ethanol.
6, this product has added surfactant---sodium sulfate of polyethenoxy ether of fatty alcohol, promptly 6501 and surfactant---coconut fatty alcohols diglycollic amide, be surfactant A ES, not only make its dissipation effect more remarkable, and also simple and convenient many to the requirement of working condition and production environment in manufacturing process; Also increased the scope of application of product of the present invention.This product is without any harm, not only medical institutions can use, can also expand to civilian, as wash fruit, vegetables, sanitary equipment, the usefulness that aspect domestic hygiene, can be used as men and women's health care cleaning, all right as usefulness such as urgent disinfection of drinking water and swimming-pool water sterilizations, so its scope of application is very extensive.
Advantageous effect of the present invention is:
Quick-effective iodine disinfectant of the present invention, promptly " Wei Huakangfu iodine " is the dark-brown transparency liquid, can dissolve each other with the water of arbitrary proportion under the room temperature, haze-free nothing precipitation, its properties of Aqueous Solution is stable, free from extraneous odour, nonirritant, corrosivity are little, xanthochromia wash-out very easily, and fungicidal spectrum is wide, can kill each bacterioid, virus, mycotic spore and bacterial spore etc., killing action is efficiently quick, and is nontoxic, is a kind of both broad-spectrum biocides of having both of decontamination, disinfection that wash.Have that Disinfection Effect is remarkable, production technology is simple, production cost is low, have wide range of applications, and advantage very easy to use.
Embodiment
One, the present invention tests through disease prevention and control center, Liaoning Province, obtains as drawing a conclusion:
(1), acute eye irritation test:
1, be subjected to the reagent product: quick-effective iodine disinfectant of the present invention, i.e. " Wei Huakangfu iodine ", " Wei Huakangfu board iodic disinfecting liquid ", this product is a brown liquid.
2, animal subject: raise the large ear rabbit that factory provides by Shenyang City's Yuhong District zoopery, regular grade, male, 100, about body weight 2-3 kilogram.The laboratory animal production licence number is SCXK (the Liao Dynasty) 2003-0011 number.
3, bulk is exempted from material: providing the laboratory animal production licence number by Shenyang City's Yuhong District zoopery feed factory is SCXK (the Liao Dynasty) 2003-0011 number.
4, test condition: the barrier system Animal Lab., 22 ± 1.5 ℃ of temperature, humidity 50% ± 10%, work illumination 160-280lx, noise be less than 60dB, and the laboratory animal occupancy permit number is SYXK (the Liao Dynasty) 2003-0011 number.
5, experimental technique:
1. test basis: Ministry of Public Health's " disinfection technology standard " version in 2002.
2. the method for inspection: draw 0.1ml and tried thing, splash in the laboratory animal one side conjunctival sac, and use normal saline flushing behind the passive closed 30s, another branch hole is as normal control.1h, 24h, 48h, 72h behind the eye drip, the damage and the recovery situation of detect by an unaided eye tame rabbit cornea, iris, conjunctiva.If do not occur irritant reaction in the 72h, or 7d or 14d, the eye irritation recovery that reacts completely can the premature termination test.
By code requirement the acute irritation reaction of man rabbit cornea, iris and conjunctiva is marked, and calculate respectively every animal three different observing time 24h, 48h and four of 72h cornea, iris infringement, conjunctival congestion and chemosises aspect " average score ", i.e. the 24h of every animal, 48h and 72h scoring sum is divided by observed number 3.Respectively with the average mark and recovery time of cornea, iris infringement, conjunctival congestion and the chemosis of animal, judge by eye irritant reaction grade scale and to be tried the stimulus intensity of thing eyes.
6, conclusion:
Through evidence, when being tried thing and test, irritant reaction average integral cornea, iris, conjunctiva belong to nonirritant all less than 1, prove to be subjected to reagent product nonirritant with medicine of the present invention.
(2), vaginal mucomembranous irritant test:
Be subjected to the reagent product: quick-effective iodine disinfectant of the present invention, i.e. " Wei Huakangfu iodine ", " Wei Huakangfu board iodic disinfecting liquid ", this product is a brown liquid.
Carry out a vaginal mucosa irritation test, the result shows stimulation index less than 1, is nonirritant.
(3), skin and mucous membrane irritation experiment:
It is 0 that experimental group erythema and oedema form the scoring sum.
Conclusion: the verified reagent product that are subjected to have no side effect, to the skin nonirritant.
(4), acute mouthful of toxicity test: the diet of experimental group animal, movable no abnormality seen, nothing is dead in the observation period.
Conclusion: verifiedly be subjected to reagent product avirulence, have no side effect.
Two, product of the present invention be a kind of fungicidal spectrum extensively and efficiently a kind of fast again novel quick-acting sanitas.Prove by above-mentioned laboratory qualification, use available iodine concentration can kill Escherichia coli (8099) and staphylococcus aureus (ATCC6538) in 1 minute fully as 10ppm, killing the bacillus subtilis var bud fully embraces (ATCC9372) and then needs available iodine concentration at 1250ppm30 minute, 2500ppm15 minute 15 minutes, bacterial spore is the powerhouse of resistance in all microorganisms, promptly claims this disinfectant to be the high level disinfection agent or to be referred to as bactericidal agent if it can be killed.This product is subjected to organic substance influence little, and the high concentration available iodine is subjected to organic substance influence very little, exists hardly.This product good stability was observed through the time in 3 years, and former medicine available iodine is 1% o'clock, and a month resolution ratio only is 0.0001%, and nondiscolouring does not have precipitation.
Three, product range of application of the present invention is as follows:
1, skin and mucous membrane disinfection; Can be used for generally washing one's hands and patient's handwashing disinfection, available 300~500ppm embathes, and also available 5000ppm pours 3ml in the hand into, then the arm part that will sterilize of wiping repeatedly; Gastrointestinal procedures is for reducing postoperative infection, and it is preceding with 200 to perform the operation---and the 300ppm bowel lavage also can be used for department of obstetrics and gynecology's washing vagina etc. to kill bacterium in the intestines and stomach.Can be used for injection and operation portion skin degerming.
2, be widely used in the wiping or the soaking disinfection of medicine equipment, generally dentistry had enough to meet the need medicine equipment fast, as dental drill, probe, mouth mirror, tweezers etc., each section's office treatment is the sterilization of the medicine equipment of turnover fast.Extensively this medicine is used for the particularly sterilization of gastroscope of endoscope abroad, this is significant to the iatrogenic infection approach that cuts off hepatitis type B virus.
3, because two kinds of effects of this product decontamination are had both, therefore can be widely used in swimming pool, bathing pool water sterilization, the sterilization of public hair dressing tools etc.
4, because iodine can see through skin through the lymph circulation sterilization, thereby this product also has symptoms such as furuncle, wound such as treatment skin purulent infection such as anti-inflammation detumescence, also is battlefield war wound rescue non-defective unit.
5, can be civilian, as flushing fruit, vegetables, meal tea set, sanitary equipment etc.
6, can be used for the domestic hygiene aspect, for example: as the usefulness of the men and women of family health care cleaning.
7, use as urgent disinfection of drinking water.
Four, embodiment 1:
A kind of quick-effective iodine disinfectant, as family life sterilization institute's time spent, it is to be formed than preparation by following raw materials by weight portion:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 1: 4: 0.2: 0.2
Its production method is as follows:
(1) gets iodine 100g by above-mentioned ratio of weight and number, be ground into powdery, and then add potassium iodide 100g, continue to grind to form powdery, add polyvinylpyrrolidone 400g at last, continue to grind mixing, get A;
(2) under the normal temperature state, above-mentioned powder raw material A to be inserted in the retort of sealing that temperature is a room temperature, Solid complexing 12 hours stirs 2 times therebetween;
(3) after the arrival of Solid complexing time, add distilled water, the limit edged stirs;
(4) add distilled water after, making its available iodine concentration is 0.2%, adding distil water does not have any particle or suspension floccule after be dissolved into the shinny transparency liquid of sepia in 6 hours fully;
(5) add sodium sulfate of polyethenoxy ether of fatty alcohol 20g and coconut fatty alcohols diglycollic amide 20g in proportion, stir at normal temperatures, carry out packing by the Packing Unit size, promptly.
Embodiment 2:
A kind of quick-effective iodine disinfectant, it is to be formed than preparation by following raw materials by weight portion:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 2: 5: 0.3: 0.3
Its production method is:
(1) gets iodine 100g by above-mentioned ratio of weight and number, be ground into powdery, and then add potassium iodide 200g, continue to grind to form powdery, add polyvinylpyrrolidone 500g at last, continue to grind mixing, get A;
(2) under the normal temperature state, above-mentioned powder raw material A to be inserted in the retort of sealing that temperature is a room temperature, Solid complexing 18 hours stirs 2 times therebetween;
(3) after the arrival of Solid complexing time, add distilled water, the limit edged stirs;
(4) add distilled water after, making its available iodine concentration is 1%, adding distil water does not have any particle or suspension floccule after be dissolved into the shinny transparency liquid of sepia in 9 hours fully;
(5) add sodium sulfate of polyethenoxy ether of fatty alcohol 30g and coconut fatty alcohols diglycollic amide 30g in proportion, stir at normal temperatures, carry out packing by the Packing Unit size, promptly.
Embodiment 3:
A kind of quick-effective iodine disinfectant, when medical, it is to be formed than preparation by following raw materials by weight portion:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 3: 7: 0.5: 0.5
Its production method is:
(1) gets iodine 100g by above-mentioned ratio of weight and number, be ground into powdery, and then add potassium iodide 300g, continue to grind to form powdery, add polyvinylpyrrolidone 700g at last, continue to grind mixing, get A;
(2) under the normal temperature state, above-mentioned powder raw material A to be inserted in the retort of sealing that temperature is a room temperature, Solid complexing 24 hours stirs 3 times therebetween;
(3) after the arrival of Solid complexing time, add distilled water, the limit edged stirs;
(4) add distilled water after, making its available iodine concentration is 2%, adding distil water does not have any particle or suspension floccule after be dissolved into the shinny transparency liquid of sepia in 12 hours fully;
(5) add sodium sulfate of polyethenoxy ether of fatty alcohol 50g and coconut fatty alcohols diglycollic amide 50g in proportion, stir at normal temperatures, carry out packing by the Packing Unit size, promptly.
Claims (5)
1, a kind of quick-effective iodine disinfectant is characterized in that it is to be formed than preparation by following raw materials by weight portion:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: (1~3): (4~7): (0.2~0.5): (0.2~0.5).
2, quick-effective iodine disinfectant according to claim 1 is characterized in that raw material weight umber proportioning of the present invention is:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 1: 4: 0.2: 0.2.
3, quick-effective iodine disinfectant according to claim 1 is characterized in that raw material weight umber proportioning of the present invention is:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 2: 5: 0.3: 0.3.
4, quick-effective iodine disinfectant according to claim 1 is characterized in that raw material weight umber proportioning of the present invention is:
Iodine: potassium iodide: polyvinylpyrrolidone: sodium sulfate of polyethenoxy ether of fatty alcohol: coconut fatty alcohols diglycollic amide=1: 3: 7: 0.5: 0.5.
5, a kind of production method of quick-effective iodine disinfectant is characterized in that:
(1) gets iodine by the described ratio of weight and number of claim 1, be ground into powdery, and then add potassium iodide, continue to grind to form powdery, add polyvinylpyrrolidone at last, continue to grind mixing, get A;
(2) under the normal temperature state, above-mentioned powder raw material A to be inserted in the retort of sealing that temperature is a room temperature, Solid complexing 12~24 hours stirs 2~3 times therebetween;
(3) after the arrival of Solid complexing time, add distilled water, the limit edged stirs;
(4) add distilled water after, making its available iodine concentration is 0.2~2%, adding distil water does not have any particle or suspension floccule after be dissolved into the shinny transparency liquid of sepia in 6~12 hours fully;
(5) add sodium sulfate of polyethenoxy ether of fatty alcohol and coconut fatty alcohols diglycollic amide by the described ratio of weight and number of claim 1, stir at normal temperatures, carry out packing by the Packing Unit size, promptly.
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101862347A (en) * | 2010-06-20 | 2010-10-20 | 吴岗 | Disinfectant |
CN102311887A (en) * | 2011-08-18 | 2012-01-11 | 瓮福(集团)有限责任公司 | Iodine-containing antibacterial washing agent and its preparation method |
CN103210958A (en) * | 2013-05-15 | 2013-07-24 | 上海宇昂新材料科技有限公司 | Aquaculture compound iodine solution and preparation method thereof |
CN104224825A (en) * | 2014-09-16 | 2014-12-24 | 王子章 | Disinfectant and preparation method thereof |
CN104523747A (en) * | 2014-12-22 | 2015-04-22 | 安徽源尔康医药生物科技有限公司 | Easy-to-clean iodophor |
CN107518001A (en) * | 2017-09-01 | 2017-12-29 | 四川创美克科技有限公司 | A kind of new disinfectant of alcohol containing iodo-salicylic acid and preparation method thereof |
CN108455689A (en) * | 2018-01-18 | 2018-08-28 | 广东金海润生物科技有限公司 | A kind of compound iodine water quality cleansing agent |
CN114149870A (en) * | 2021-12-16 | 2022-03-08 | 广东科伦药业有限公司 | Complex iodine floor disinfection cleaning agent and preparation process thereof |
-
2005
- 2005-12-23 CN CN 200510130839 patent/CN1788568A/en active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101862347A (en) * | 2010-06-20 | 2010-10-20 | 吴岗 | Disinfectant |
CN102311887A (en) * | 2011-08-18 | 2012-01-11 | 瓮福(集团)有限责任公司 | Iodine-containing antibacterial washing agent and its preparation method |
CN102311887B (en) * | 2011-08-18 | 2013-01-16 | 瓮福(集团)有限责任公司 | Iodine-containing antibacterial washing agent |
CN103210958A (en) * | 2013-05-15 | 2013-07-24 | 上海宇昂新材料科技有限公司 | Aquaculture compound iodine solution and preparation method thereof |
CN104224825A (en) * | 2014-09-16 | 2014-12-24 | 王子章 | Disinfectant and preparation method thereof |
CN104523747A (en) * | 2014-12-22 | 2015-04-22 | 安徽源尔康医药生物科技有限公司 | Easy-to-clean iodophor |
CN107518001A (en) * | 2017-09-01 | 2017-12-29 | 四川创美克科技有限公司 | A kind of new disinfectant of alcohol containing iodo-salicylic acid and preparation method thereof |
CN108455689A (en) * | 2018-01-18 | 2018-08-28 | 广东金海润生物科技有限公司 | A kind of compound iodine water quality cleansing agent |
CN114149870A (en) * | 2021-12-16 | 2022-03-08 | 广东科伦药业有限公司 | Complex iodine floor disinfection cleaning agent and preparation process thereof |
CN114149870B (en) * | 2021-12-16 | 2024-04-16 | 广东科伦药业有限公司 | Complex iodine floor disinfection cleaning agent and preparation process thereof |
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