CN1787837A - 防止和治疗癌转移以及与癌转移相关的骨质损失的方法 - Google Patents

防止和治疗癌转移以及与癌转移相关的骨质损失的方法 Download PDF

Info

Publication number: CN1787837A
Authority: CN; China
Prior art keywords: csf; antibody; cancer; antagonist; medicine
Prior art date: 2002-11-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CNA2003801088289A

Other languages

English (en)

Chinese (zh)

Inventor

D·L·齐默尔曼

G·哈罗

C·刘

K·科特斯

W·M·卡瓦诺

L·龙

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

NOVARTIS VACCINES and DIAGNOSTIC Inc

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-15

Filing date

2003-11-17

Publication date

2006-06-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32326424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1787837(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-11-17 Application filed by Chiron Corp filed Critical Chiron Corp

2006-06-14 Publication of CN1787837A publication Critical patent/CN1787837A/zh

Status Pending legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 278
206010028980 Neoplasm Diseases 0.000 title claims description 150
201000011510 cancer Diseases 0.000 title claims description 123
206010027476 Metastases Diseases 0.000 title description 61
230000009401 metastasis Effects 0.000 title description 58
206010065687 Bone loss Diseases 0.000 title description 36
102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims abstract description 475
108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims abstract description 475
239000005557 antagonist Substances 0.000 claims abstract description 213
239000003814 drug Substances 0.000 claims abstract description 153
208000037819 metastatic cancer Diseases 0.000 claims abstract description 88
208000011575 metastatic malignant neoplasm Diseases 0.000 claims abstract description 88
238000012216 screening Methods 0.000 claims abstract description 22
230000004614 tumor growth Effects 0.000 claims abstract description 19
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
108090000765 processed proteins & peptides Proteins 0.000 claims description 210
102000004196 processed proteins & peptides Human genes 0.000 claims description 178
229920001184 polypeptide Polymers 0.000 claims description 148
210000004027 cell Anatomy 0.000 claims description 125
210000000988 bone and bone Anatomy 0.000 claims description 65
238000011282 treatment Methods 0.000 claims description 53
229940124597 therapeutic agent Drugs 0.000 claims description 52
-1 pamldronate Chemical compound 0.000 claims description 40
230000003993 interaction Effects 0.000 claims description 36
239000000203 mixture Substances 0.000 claims description 36
210000002997 osteoclast Anatomy 0.000 claims description 36
238000002360 preparation method Methods 0.000 claims description 34
210000004881 tumor cell Anatomy 0.000 claims description 29
230000015572 biosynthetic process Effects 0.000 claims description 24
206010061289 metastatic neoplasm Diseases 0.000 claims description 22
229940079593 drug Drugs 0.000 claims description 21
241000124008 Mammalia Species 0.000 claims description 20
238000001727 in vivo Methods 0.000 claims description 18
230000001225 therapeutic effect Effects 0.000 claims description 16
230000001394 metastastic effect Effects 0.000 claims description 15
102000007644 Colony-Stimulating Factors Human genes 0.000 claims description 14
108010071942 Colony-Stimulating Factors Proteins 0.000 claims description 14
108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 14
102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 14
206010035226 Plasma cell myeloma Diseases 0.000 claims description 14
230000004069 differentiation Effects 0.000 claims description 14
210000004408 hybridoma Anatomy 0.000 claims description 14
206010025323 Lymphomas Diseases 0.000 claims description 10
208000024770 Thyroid neoplasm Diseases 0.000 claims description 10
230000002829 reductive effect Effects 0.000 claims description 10
230000008685 targeting Effects 0.000 claims description 10
206010009944 Colon cancer Diseases 0.000 claims description 9
238000001959 radiotherapy Methods 0.000 claims description 9
208000034578 Multiple myelomas Diseases 0.000 claims description 8
206010038389 Renal cancer Diseases 0.000 claims description 8
206010039491 Sarcoma Diseases 0.000 claims description 8
230000007423 decrease Effects 0.000 claims description 8
201000010536 head and neck cancer Diseases 0.000 claims description 8
208000014829 head and neck neoplasm Diseases 0.000 claims description 8
208000032839 leukemia Diseases 0.000 claims description 8
201000001441 melanoma Diseases 0.000 claims description 8
201000008968 osteosarcoma Diseases 0.000 claims description 8
206010041823 squamous cell carcinoma Diseases 0.000 claims description 8
201000002510 thyroid cancer Diseases 0.000 claims description 8
206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
206010029260 Neuroblastoma Diseases 0.000 claims description 7
206010061535 Ovarian neoplasm Diseases 0.000 claims description 7
208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 7
208000009956 adenocarcinoma Diseases 0.000 claims description 7
208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims description 7
238000001514 detection method Methods 0.000 claims description 7
210000005002 female reproductive tract Anatomy 0.000 claims description 7
238000009472 formulation Methods 0.000 claims description 7
239000003053 toxin Substances 0.000 claims description 7
231100000765 toxin Toxicity 0.000 claims description 7
238000012546 transfer Methods 0.000 claims description 7
208000003174 Brain Neoplasms Diseases 0.000 claims description 6
102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 6
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 6
208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
239000012830 cancer therapeutic Substances 0.000 claims description 6
ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims description 6
229960002286 clodronic acid Drugs 0.000 claims description 6
208000029742 colonic neoplasm Diseases 0.000 claims description 6
230000008878 coupling Effects 0.000 claims description 6
238000010168 coupling process Methods 0.000 claims description 6
238000005859 coupling reaction Methods 0.000 claims description 6
239000003937 drug carrier Substances 0.000 claims description 6
206010017758 gastric cancer Diseases 0.000 claims description 6
238000006386 neutralization reaction Methods 0.000 claims description 6
201000000849 skin cancer Diseases 0.000 claims description 6
201000011549 stomach cancer Diseases 0.000 claims description 6
DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims description 5
206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 5
206010033128 Ovarian cancer Diseases 0.000 claims description 5
206010061902 Pancreatic neoplasm Diseases 0.000 claims description 5
239000003085 diluting agent Substances 0.000 claims description 5
229940009626 etidronate Drugs 0.000 claims description 5
230000005764 inhibitory process Effects 0.000 claims description 5
208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 5
239000000546 pharmaceutical excipient Substances 0.000 claims description 5
OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims description 4
206010005003 Bladder cancer Diseases 0.000 claims description 4
206010008342 Cervix carcinoma Diseases 0.000 claims description 4
208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
206010014759 Endometrial neoplasm Diseases 0.000 claims description 4
MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims description 4
208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 4
229940062527 alendronate Drugs 0.000 claims description 4
239000006143 cell culture medium Substances 0.000 claims description 4
201000010881 cervical cancer Diseases 0.000 claims description 4
229940015872 ibandronate Drugs 0.000 claims description 4
230000009467 reduction Effects 0.000 claims description 4
201000005112 urinary bladder cancer Diseases 0.000 claims description 4
229940126619 mouse monoclonal antibody Drugs 0.000 claims description 3
230000003248 secreting effect Effects 0.000 claims description 3
239000001177 diphosphate Substances 0.000 claims 6
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical group [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 6
235000011180 diphosphates Nutrition 0.000 claims 6
230000000977 initiatory effect Effects 0.000 claims 4
108010048734 sclerotin Proteins 0.000 claims 4
208000006265 Renal cell carcinoma Diseases 0.000 claims 3
208000033781 Thyroid carcinoma Diseases 0.000 claims 3
201000010989 colorectal carcinoma Diseases 0.000 claims 3
201000003914 endometrial carcinoma Diseases 0.000 claims 3
229940000351 hemocyte Drugs 0.000 claims 3
210000003677 hemocyte Anatomy 0.000 claims 3
201000001514 prostate carcinoma Diseases 0.000 claims 3
201000010174 renal carcinoma Diseases 0.000 claims 3
201000008261 skin carcinoma Diseases 0.000 claims 3
208000017572 squamous cell neoplasm Diseases 0.000 claims 3
208000013077 thyroid gland carcinoma Diseases 0.000 claims 3
DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 claims 2
238000012856 packing Methods 0.000 claims 2
UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
229940019375 tiludronate Drugs 0.000 claims 2
206010027452 Metastases to bone Diseases 0.000 abstract description 9
108090000623 proteins and genes Proteins 0.000 description 150
230000027455 binding Effects 0.000 description 136
102000004169 proteins and genes Human genes 0.000 description 108
150000001875 compounds Chemical class 0.000 description 98
235000018102 proteins Nutrition 0.000 description 89
241000282414 Homo sapiens Species 0.000 description 66
235000001014 amino acid Nutrition 0.000 description 63
229940024606 amino acid Drugs 0.000 description 57
150000001413 amino acids Chemical class 0.000 description 56
230000000694 effects Effects 0.000 description 48
239000012634 fragment Substances 0.000 description 48
239000000427 antigen Substances 0.000 description 43
108091007433 antigens Proteins 0.000 description 43
102000036639 antigens Human genes 0.000 description 43
102000005962 receptors Human genes 0.000 description 42
108020003175 receptors Proteins 0.000 description 41
238000006467 substitution reaction Methods 0.000 description 41
239000003446 ligand Substances 0.000 description 37
238000003556 assay Methods 0.000 description 32
239000000126 substance Substances 0.000 description 30
125000003275 alpha amino acid group Chemical group 0.000 description 29
102000039446 nucleic acids Human genes 0.000 description 28
108020004707 nucleic acids Proteins 0.000 description 28
150000007523 nucleic acids Chemical class 0.000 description 28
241001465754 Metazoa Species 0.000 description 27
230000014509 gene expression Effects 0.000 description 26
238000012360 testing method Methods 0.000 description 26
241001529936 Murinae Species 0.000 description 24
238000004519 manufacturing process Methods 0.000 description 24
239000012528 membrane Substances 0.000 description 22
210000004379 membrane Anatomy 0.000 description 22
239000003795 chemical substances by application Substances 0.000 description 20
108091034117 Oligonucleotide Proteins 0.000 description 19
230000000692 anti-sense effect Effects 0.000 description 19
230000006870 function Effects 0.000 description 18
238000000338 in vitro Methods 0.000 description 18
102000008394 Immunoglobulin Fragments Human genes 0.000 description 17
108010021625 Immunoglobulin Fragments Proteins 0.000 description 17
230000004071 biological effect Effects 0.000 description 17
230000035772 mutation Effects 0.000 description 17
150000003384 small molecules Chemical class 0.000 description 17
239000000243 solution Substances 0.000 description 17
108090000994 Catalytic RNA Proteins 0.000 description 16
102000053642 Catalytic RNA Human genes 0.000 description 16
108020004414 DNA Proteins 0.000 description 16
239000003153 chemical reaction reagent Substances 0.000 description 16
108091092562 ribozyme Proteins 0.000 description 16
238000002560 therapeutic procedure Methods 0.000 description 16
230000004048 modification Effects 0.000 description 15
238000012986 modification Methods 0.000 description 15
108060003951 Immunoglobulin Proteins 0.000 description 14
230000000295 complement effect Effects 0.000 description 14
102000018358 immunoglobulin Human genes 0.000 description 14
230000002401 inhibitory effect Effects 0.000 description 14
108020004999 messenger RNA Proteins 0.000 description 14
239000000047 product Substances 0.000 description 14
229920005989 resin Polymers 0.000 description 14
239000011347 resin Substances 0.000 description 14
238000003786 synthesis reaction Methods 0.000 description 14
108091032973 (ribonucleotides)n+m Proteins 0.000 description 13
230000003472 neutralizing effect Effects 0.000 description 13
229920002307 Dextran Polymers 0.000 description 12
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 12
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 12
239000002585 base Substances 0.000 description 12
229960002086 dextran Drugs 0.000 description 12
239000000539 dimer Substances 0.000 description 12
238000013537 high throughput screening Methods 0.000 description 12
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 11
206010006187 Breast cancer Diseases 0.000 description 11
208000026310 Breast neoplasm Diseases 0.000 description 11
108010047041 Complementarity Determining Regions Proteins 0.000 description 11
102100024568 Tumor necrosis factor ligand superfamily member 11 Human genes 0.000 description 11
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 11
125000000539 amino acid group Chemical group 0.000 description 11
238000003776 cleavage reaction Methods 0.000 description 11
235000018417 cysteine Nutrition 0.000 description 11
238000005516 engineering process Methods 0.000 description 11
239000003112 inhibitor Substances 0.000 description 11
108091033319 polynucleotide Proteins 0.000 description 11
102000040430 polynucleotide Human genes 0.000 description 11
230000007017 scission Effects 0.000 description 11
108010025832 RANK Ligand Proteins 0.000 description 10
239000002253 acid Substances 0.000 description 10
238000004458 analytical method Methods 0.000 description 10
201000010099 disease Diseases 0.000 description 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
239000012636 effector Substances 0.000 description 10
239000002157 polynucleotide Substances 0.000 description 10
229940122361 Bisphosphonate Drugs 0.000 description 9
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 9
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 9
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 9
230000004913 activation Effects 0.000 description 9
239000002246 antineoplastic agent Substances 0.000 description 9
150000004663 bisphosphonates Chemical group 0.000 description 9
230000004927 fusion Effects 0.000 description 9
238000003780 insertion Methods 0.000 description 9
230000037431 insertion Effects 0.000 description 9
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 9
239000000178 monomer Substances 0.000 description 9
239000002773 nucleotide Substances 0.000 description 9
125000003729 nucleotide group Chemical group 0.000 description 9
229920000642 polymer Polymers 0.000 description 9
230000035755 proliferation Effects 0.000 description 9
238000000159 protein binding assay Methods 0.000 description 9
238000012552 review Methods 0.000 description 9
239000002904 solvent Substances 0.000 description 9
239000000725 suspension Substances 0.000 description 9
210000001519 tissue Anatomy 0.000 description 9
101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 description 8
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 8
102000004190 Enzymes Human genes 0.000 description 8
108090000790 Enzymes Proteins 0.000 description 8
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 8
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 8
108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 description 8
108091028043 Nucleic acid sequence Proteins 0.000 description 8
230000000890 antigenic effect Effects 0.000 description 8
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 8
229960002433 cysteine Drugs 0.000 description 8
125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 description 8
229940088598 enzyme Drugs 0.000 description 8
238000009396 hybridization Methods 0.000 description 8
239000002502 liposome Substances 0.000 description 8
230000005855 radiation Effects 0.000 description 8
239000000758 substrate Substances 0.000 description 8
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 7
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 7
208000000236 Prostatic Neoplasms Diseases 0.000 description 7
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
230000000259 anti-tumor effect Effects 0.000 description 7
238000013459 approach Methods 0.000 description 7
210000004899 c-terminal region Anatomy 0.000 description 7
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
238000006243 chemical reaction Methods 0.000 description 7
238000002512 chemotherapy Methods 0.000 description 7
238000012217 deletion Methods 0.000 description 7
230000037430 deletion Effects 0.000 description 7
238000011161 development Methods 0.000 description 7
230000018109 developmental process Effects 0.000 description 7
230000005670 electromagnetic radiation Effects 0.000 description 7
238000001415 gene therapy Methods 0.000 description 7
229940127121 immunoconjugate Drugs 0.000 description 7
230000002163 immunogen Effects 0.000 description 7
239000007924 injection Substances 0.000 description 7
238000002347 injection Methods 0.000 description 7
150000002611 lead compounds Chemical class 0.000 description 7
239000003921 oil Substances 0.000 description 7
235000019198 oils Nutrition 0.000 description 7
238000002823 phage display Methods 0.000 description 7
230000002265 prevention Effects 0.000 description 7
235000002639 sodium chloride Nutrition 0.000 description 7
239000007790 solid phase Substances 0.000 description 7
238000013518 transcription Methods 0.000 description 7
230000035897 transcription Effects 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 6
102000004127 Cytokines Human genes 0.000 description 6
108090000695 Cytokines Proteins 0.000 description 6
102000018233 Fibroblast Growth Factor Human genes 0.000 description 6
108050007372 Fibroblast Growth Factor Proteins 0.000 description 6
108010067902 Peptide Library Proteins 0.000 description 6
108020004511 Recombinant DNA Proteins 0.000 description 6
108700008625 Reporter Genes Proteins 0.000 description 6
NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 6
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 6
229940100198 alkylating agent Drugs 0.000 description 6
239000002168 alkylating agent Substances 0.000 description 6
125000003277 amino group Chemical group 0.000 description 6
230000000340 anti-metabolite Effects 0.000 description 6
229940100197 antimetabolite Drugs 0.000 description 6
239000002256 antimetabolite Substances 0.000 description 6
239000002738 chelating agent Substances 0.000 description 6
238000004587 chromatography analysis Methods 0.000 description 6
229940126864 fibroblast growth factor Drugs 0.000 description 6
108020001507 fusion proteins Proteins 0.000 description 6
102000037865 fusion proteins Human genes 0.000 description 6
230000013595 glycosylation Effects 0.000 description 6
238000006206 glycosylation reaction Methods 0.000 description 6
230000028993 immune response Effects 0.000 description 6
229940072221 immunoglobulins Drugs 0.000 description 6
150000002632 lipids Chemical class 0.000 description 6
208000020816 lung neoplasm Diseases 0.000 description 6
230000007246 mechanism Effects 0.000 description 6
201000000050 myeloid neoplasm Diseases 0.000 description 6
229920001223 polyethylene glycol Polymers 0.000 description 6
230000008569 process Effects 0.000 description 6
210000002966 serum Anatomy 0.000 description 6
235000000346 sugar Nutrition 0.000 description 6
238000001356 surgical procedure Methods 0.000 description 6
238000013519 translation Methods 0.000 description 6
229910001868 water Inorganic materials 0.000 description 6
241000282412 Homo Species 0.000 description 5
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 5
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 5
208000008839 Kidney Neoplasms Diseases 0.000 description 5
125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 description 5
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 5
208000003076 Osteolysis Diseases 0.000 description 5
239000002202 Polyethylene glycol Substances 0.000 description 5
206010060862 Prostate cancer Diseases 0.000 description 5
150000001412 amines Chemical class 0.000 description 5
238000010171 animal model Methods 0.000 description 5
238000009175 antibody therapy Methods 0.000 description 5
230000008901 benefit Effects 0.000 description 5
230000037396 body weight Effects 0.000 description 5
210000000481 breast Anatomy 0.000 description 5
150000001720 carbohydrates Chemical class 0.000 description 5
239000000969 carrier Substances 0.000 description 5
238000007385 chemical modification Methods 0.000 description 5
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 5
238000003501 co-culture Methods 0.000 description 5
239000003184 complementary RNA Substances 0.000 description 5
239000003636 conditioned culture medium Substances 0.000 description 5
235000014113 dietary fatty acids Nutrition 0.000 description 5
239000002552 dosage form Substances 0.000 description 5
229930195729 fatty acid Natural products 0.000 description 5
239000000194 fatty acid Substances 0.000 description 5
229940088597 hormone Drugs 0.000 description 5
239000005556 hormone Substances 0.000 description 5
230000001965 increasing effect Effects 0.000 description 5
201000010982 kidney cancer Diseases 0.000 description 5
208000029791 lytic metastatic bone lesion Diseases 0.000 description 5
229960004961 mechlorethamine Drugs 0.000 description 5
230000001404 mediated effect Effects 0.000 description 5
210000001616 monocyte Anatomy 0.000 description 5
210000000963 osteoblast Anatomy 0.000 description 5
239000000843 powder Substances 0.000 description 5
239000002243 precursor Substances 0.000 description 5
238000011160 research Methods 0.000 description 5
239000000523 sample Substances 0.000 description 5
208000024891 symptom Diseases 0.000 description 5
108700012359 toxins Proteins 0.000 description 5
230000009261 transgenic effect Effects 0.000 description 5
238000010396 two-hybrid screening Methods 0.000 description 5
108020005544 Antisense RNA Proteins 0.000 description 4
102100023995 Beta-nerve growth factor Human genes 0.000 description 4
108010006654 Bleomycin Proteins 0.000 description 4
230000004568 DNA-binding Effects 0.000 description 4
QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 4
238000002965 ELISA Methods 0.000 description 4
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 4
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
239000000095 Growth Hormone-Releasing Hormone Substances 0.000 description 4
102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 description 4
102000003745 Hepatocyte Growth Factor Human genes 0.000 description 4
108090000100 Hepatocyte Growth Factor Proteins 0.000 description 4
108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 4
102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 4
102000006992 Interferon-alpha Human genes 0.000 description 4
108010047761 Interferon-alpha Proteins 0.000 description 4
102000003996 Interferon-beta Human genes 0.000 description 4
108090000467 Interferon-beta Proteins 0.000 description 4
108010000817 Leuprolide Proteins 0.000 description 4
101710127797 Macrophage colony-stimulating factor 1 Proteins 0.000 description 4
102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 description 4
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 4
108010025020 Nerve Growth Factor Proteins 0.000 description 4
241000906034 Orthops Species 0.000 description 4
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 4
208000000453 Skin Neoplasms Diseases 0.000 description 4
101710142969 Somatoliberin Proteins 0.000 description 4
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 4
102000019197 Superoxide Dismutase Human genes 0.000 description 4
108010012715 Superoxide dismutase Proteins 0.000 description 4
102000007591 Tartrate-Resistant Acid Phosphatase Human genes 0.000 description 4
108010032050 Tartrate-Resistant Acid Phosphatase Proteins 0.000 description 4
102000004887 Transforming Growth Factor beta Human genes 0.000 description 4
108090001012 Transforming Growth Factor beta Proteins 0.000 description 4
108060008682 Tumor Necrosis Factor Proteins 0.000 description 4
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 4
102100032236 Tumor necrosis factor receptor superfamily member 11B Human genes 0.000 description 4
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 4
230000002159 abnormal effect Effects 0.000 description 4
150000007513 acids Chemical class 0.000 description 4
239000012190 activator Substances 0.000 description 4
239000002671 adjuvant Substances 0.000 description 4
238000007112 amidation reaction Methods 0.000 description 4
229960001561 bleomycin Drugs 0.000 description 4
OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 4
210000000601 blood cell Anatomy 0.000 description 4
239000000872 buffer Substances 0.000 description 4
238000004422 calculation algorithm Methods 0.000 description 4
235000014633 carbohydrates Nutrition 0.000 description 4
210000001072 colon Anatomy 0.000 description 4
239000002299 complementary DNA Substances 0.000 description 4
230000021615 conjugation Effects 0.000 description 4
238000007796 conventional method Methods 0.000 description 4
229960004679 doxorubicin Drugs 0.000 description 4
239000003623 enhancer Substances 0.000 description 4
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 4
229960002949 fluorouracil Drugs 0.000 description 4
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 4
150000004676 glycans Chemical class 0.000 description 4
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 4
229940035638 gonadotropin-releasing hormone Drugs 0.000 description 4
239000008187 granular material Substances 0.000 description 4
230000012010 growth Effects 0.000 description 4
239000003102 growth factor Substances 0.000 description 4
238000004128 high performance liquid chromatography Methods 0.000 description 4
235000014304 histidine Nutrition 0.000 description 4
125000000487 histidyl group Chemical class [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 4
230000003053 immunization Effects 0.000 description 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
230000003834 intracellular effect Effects 0.000 description 4
230000009545 invasion Effects 0.000 description 4
GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 4
229960004338 leuprorelin Drugs 0.000 description 4
210000004185 liver Anatomy 0.000 description 4
201000005202 lung cancer Diseases 0.000 description 4
210000004698 lymphocyte Anatomy 0.000 description 4
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 4
HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 4
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 4
229940053128 nerve growth factor Drugs 0.000 description 4
230000000010 osteolytic effect Effects 0.000 description 4
230000002611 ovarian Effects 0.000 description 4
230000003647 oxidation Effects 0.000 description 4
238000007254 oxidation reaction Methods 0.000 description 4
WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 description 4
210000000496 pancreas Anatomy 0.000 description 4
229920001282 polysaccharide Polymers 0.000 description 4
239000005017 polysaccharide Substances 0.000 description 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
125000006239 protecting group Chemical group 0.000 description 4
238000000746 purification Methods 0.000 description 4
239000002534 radiation-sensitizing agent Substances 0.000 description 4
238000003127 radioimmunoassay Methods 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
210000002784 stomach Anatomy 0.000 description 4
239000000375 suspending agent Substances 0.000 description 4
239000003826 tablet Substances 0.000 description 4
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 4
239000013598 vector Substances 0.000 description 4
229960003048 vinblastine Drugs 0.000 description 4
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 4
238000005406 washing Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
VGGGPCQERPFHOB-MCIONIFRSA-N Bestatin Chemical compound CC(C)C[C@H](C(O)=O)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1 VGGGPCQERPFHOB-MCIONIFRSA-N 0.000 description 3
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 3
AOCCBINRVIKJHY-UHFFFAOYSA-N Carmofur Chemical compound CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O AOCCBINRVIKJHY-UHFFFAOYSA-N 0.000 description 3
DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 3
LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 3
108091026890 Coding region Proteins 0.000 description 3
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 3
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
241000196324 Embryophyta Species 0.000 description 3
241000588724 Escherichia coli Species 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
241000724791 Filamentous phage Species 0.000 description 3
108700012941 GNRH1 Proteins 0.000 description 3
102000016844 Immunoglobulin-like domains Human genes 0.000 description 3
108050006430 Immunoglobulin-like domains Proteins 0.000 description 3
108090001007 Interleukin-8 Proteins 0.000 description 3
102000004890 Interleukin-8 Human genes 0.000 description 3
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 3
239000004472 Lysine Substances 0.000 description 3
102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 3
108010052285 Membrane Proteins Proteins 0.000 description 3
241000699660 Mus musculus Species 0.000 description 3
229930012538 Paclitaxel Natural products 0.000 description 3
229920002873 Polyethylenimine Polymers 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 3
240000004808 Saccharomyces cerevisiae Species 0.000 description 3
150000004753 Schiff bases Chemical class 0.000 description 3
239000004473 Threonine Substances 0.000 description 3
HIHOWBSBBDRPDW-PTHRTHQKSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] n-[2-(dimethylamino)ethyl]carbamate Chemical compound C1C=C2C[C@@H](OC(=O)NCCN(C)C)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HIHOWBSBBDRPDW-PTHRTHQKSA-N 0.000 description 3
230000002378 acidificating effect Effects 0.000 description 3
230000003213 activating effect Effects 0.000 description 3
239000000654 additive Substances 0.000 description 3
238000001042 affinity chromatography Methods 0.000 description 3
238000012867 alanine scanning Methods 0.000 description 3
108700025316 aldesleukin Proteins 0.000 description 3
229960005310 aldesleukin Drugs 0.000 description 3
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 3
230000009435 amidation Effects 0.000 description 3
230000000118 anti-neoplastic effect Effects 0.000 description 3
229940034982 antineoplastic agent Drugs 0.000 description 3
125000003118 aryl group Chemical group 0.000 description 3
125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 3
VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 3
229960002685 biotin Drugs 0.000 description 3
235000020958 biotin Nutrition 0.000 description 3
239000011616 biotin Substances 0.000 description 3
229910052796 boron Inorganic materials 0.000 description 3
239000002775 capsule Substances 0.000 description 3
150000001718 carbodiimides Chemical class 0.000 description 3
229960004562 carboplatin Drugs 0.000 description 3
229960003261 carmofur Drugs 0.000 description 3
230000001413 cellular effect Effects 0.000 description 3
210000003679 cervix uteri Anatomy 0.000 description 3
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 3
229960004316 cisplatin Drugs 0.000 description 3
238000004590 computer program Methods 0.000 description 3
229940127089 cytotoxic agent Drugs 0.000 description 3
231100000135 cytotoxicity Toxicity 0.000 description 3
230000003013 cytotoxicity Effects 0.000 description 3
238000013461 design Methods 0.000 description 3
150000004985 diamines Chemical class 0.000 description 3
238000007876 drug discovery Methods 0.000 description 3
238000007877 drug screening Methods 0.000 description 3
239000003995 emulsifying agent Substances 0.000 description 3
210000004696 endometrium Anatomy 0.000 description 3
229960005420 etoposide Drugs 0.000 description 3
239000000284 extract Substances 0.000 description 3
229960005277 gemcitabine Drugs 0.000 description 3
SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 3
125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 3
239000001963 growth medium Substances 0.000 description 3
ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 3
230000036541 health Effects 0.000 description 3
230000002209 hydrophobic effect Effects 0.000 description 3
238000002649 immunization Methods 0.000 description 3
238000009169 immunotherapy Methods 0.000 description 3
238000000099 in vitro assay Methods 0.000 description 3
229910052500 inorganic mineral Inorganic materials 0.000 description 3
238000002955 isolation Methods 0.000 description 3
229940043355 kinase inhibitor Drugs 0.000 description 3
238000002372 labelling Methods 0.000 description 3
239000007788 liquid Substances 0.000 description 3
201000007270 liver cancer Diseases 0.000 description 3
208000014018 liver neoplasm Diseases 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
210000004962 mammalian cell Anatomy 0.000 description 3
239000003550 marker Substances 0.000 description 3
239000000463 material Substances 0.000 description 3
239000002609 medium Substances 0.000 description 3
TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 3
235000010755 mineral Nutrition 0.000 description 3
239000011707 mineral Substances 0.000 description 3
229960004857 mitomycin Drugs 0.000 description 3
238000010369 molecular cloning Methods 0.000 description 3
UNAFTICPPXVTTN-UHFFFAOYSA-N n-dodecyldodecan-1-amine;hydrobromide Chemical compound [Br-].CCCCCCCCCCCC[NH2+]CCCCCCCCCCCC UNAFTICPPXVTTN-UHFFFAOYSA-N 0.000 description 3
229930014626 natural product Natural products 0.000 description 3
150000002894 organic compounds Chemical class 0.000 description 3
229960001592 paclitaxel Drugs 0.000 description 3
229940046231 pamidronate Drugs 0.000 description 3
238000010647 peptide synthesis reaction Methods 0.000 description 3
239000000816 peptidomimetic Substances 0.000 description 3
239000008177 pharmaceutical agent Substances 0.000 description 3
239000012071 phase Substances 0.000 description 3
230000026731 phosphorylation Effects 0.000 description 3
238000006366 phosphorylation reaction Methods 0.000 description 3
239000003757 phosphotransferase inhibitor Substances 0.000 description 3
230000004962 physiological condition Effects 0.000 description 3
229920000768 polyamine Polymers 0.000 description 3
230000003389 potentiating effect Effects 0.000 description 3
210000002307 prostate Anatomy 0.000 description 3
150000003212 purines Chemical class 0.000 description 3
150000003230 pyrimidines Chemical class 0.000 description 3
230000002285 radioactive effect Effects 0.000 description 3
210000000664 rectum Anatomy 0.000 description 3
230000001105 regulatory effect Effects 0.000 description 3
150000003839 salts Chemical class 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
238000002741 site-directed mutagenesis Methods 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000003381 stabilizer Substances 0.000 description 3
239000000829 suppository Substances 0.000 description 3
230000004083 survival effect Effects 0.000 description 3
229960001603 tamoxifen Drugs 0.000 description 3
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 3
229960001674 tegafur Drugs 0.000 description 3
WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 description 3
125000003396 thiol group Chemical group [H]S* 0.000 description 3
231100000419 toxicity Toxicity 0.000 description 3
230000001988 toxicity Effects 0.000 description 3
238000001890 transfection Methods 0.000 description 3
238000011830 transgenic mouse model Methods 0.000 description 3
229950009811 ubenimex Drugs 0.000 description 3
239000003981 vehicle Substances 0.000 description 3
MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 2
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 2
108010088751 Albumins Proteins 0.000 description 2
102000009027 Albumins Human genes 0.000 description 2
108020004491 Antisense DNA Proteins 0.000 description 2
239000004475 Arginine Substances 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
208000006386 Bone Resorption Diseases 0.000 description 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
108090000565 Capsid Proteins Proteins 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
201000009030 Carcinoma Diseases 0.000 description 2
102100023321 Ceruloplasmin Human genes 0.000 description 2
RURLVUZRUFHCJO-UHFFFAOYSA-N Chromomycin A3 Natural products COC(C1Cc2cc3cc(OC4CC(OC(=O)C)C(OC5CC(O)C(OC)C(C)O5)C(C)O4)c(C)c(O)c3c(O)c2C(=O)C1OC6CC(OC7CC(C)(O)C(OC(=O)C)C(C)O7)C(O)C(C)O6)C(=O)C(O)C(C)O RURLVUZRUFHCJO-UHFFFAOYSA-N 0.000 description 2
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 2
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
108010092160 Dactinomycin Proteins 0.000 description 2
241000702421 Dependoparvovirus Species 0.000 description 2
QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical compound CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 2
SAMRUMKYXPVKPA-VFKOLLTISA-N Enocitabine Chemical compound O=C1N=C(NC(=O)CCCCCCCCCCCCCCCCCCCCC)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 SAMRUMKYXPVKPA-VFKOLLTISA-N 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 2
102000003886 Glycoproteins Human genes 0.000 description 2
108090000288 Glycoproteins Proteins 0.000 description 2
108010009202 Growth Factor Receptors Proteins 0.000 description 2
102000009465 Growth Factor Receptors Human genes 0.000 description 2
241000238631 Hexapoda Species 0.000 description 2
101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 2
VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 2
208000037147 Hypercalcaemia Diseases 0.000 description 2
108090001061 Insulin Proteins 0.000 description 2
102000004877 Insulin Human genes 0.000 description 2
102100022337 Integrin alpha-V Human genes 0.000 description 2
102000008070 Interferon-gamma Human genes 0.000 description 2
108010074328 Interferon-gamma Proteins 0.000 description 2
102000014150 Interferons Human genes 0.000 description 2
108010050904 Interferons Proteins 0.000 description 2
108010002350 Interleukin-2 Proteins 0.000 description 2
102000000588 Interleukin-2 Human genes 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
KFKWRHQBZQICHA-STQMWFEESA-N Leu-Phe Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 KFKWRHQBZQICHA-STQMWFEESA-N 0.000 description 2
108090000542 Lymphotoxin-alpha Proteins 0.000 description 2
102000004083 Lymphotoxin-alpha Human genes 0.000 description 2
XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 description 2
VFKZTMPDYBFSTM-KVTDHHQDSA-N Mitobronitol Chemical compound BrC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CBr VFKZTMPDYBFSTM-KVTDHHQDSA-N 0.000 description 2
229930192392 Mitomycin Natural products 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
108010021466 Mutant Proteins Proteins 0.000 description 2
102000008300 Mutant Proteins Human genes 0.000 description 2
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 2
108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 2
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
230000004989 O-glycosylation Effects 0.000 description 2
108010035042 Osteoprotegerin Proteins 0.000 description 2
108700020797 Parathyroid Hormone-Related Proteins 0.000 description 2
102000043299 Parathyroid hormone-related Human genes 0.000 description 2
101710178358 Peptidoglycan-associated lipoprotein Proteins 0.000 description 2
108091000080 Phosphotransferase Proteins 0.000 description 2
108010039918 Polylysine Proteins 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
241000288906 Primates Species 0.000 description 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
239000002262 Schiff base Substances 0.000 description 2
102000005157 Somatostatin Human genes 0.000 description 2
108010056088 Somatostatin Proteins 0.000 description 2
241000251131 Sphyrna Species 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
108010078233 Thymalfasin Proteins 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
102400000800 Thymosin alpha-1 Human genes 0.000 description 2
241000222355 Trametes versicolor Species 0.000 description 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
108010048673 Vitronectin Receptors Proteins 0.000 description 2
YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
230000021736 acetylation Effects 0.000 description 2
238000006640 acetylation reaction Methods 0.000 description 2
RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
239000000443 aerosol Substances 0.000 description 2
230000009824 affinity maturation Effects 0.000 description 2
238000001261 affinity purification Methods 0.000 description 2
239000000556 agonist Substances 0.000 description 2
235000004279 alanine Nutrition 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
125000003172 aldehyde group Chemical group 0.000 description 2
125000001931 aliphatic group Chemical group 0.000 description 2
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
150000001408 amides Chemical class 0.000 description 2
BBDAGFIXKZCXAH-CCXZUQQUSA-N ancitabine Chemical compound N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 BBDAGFIXKZCXAH-CCXZUQQUSA-N 0.000 description 2
229950000242 ancitabine Drugs 0.000 description 2
239000002870 angiogenesis inducing agent Substances 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
230000001772 anti-angiogenic effect Effects 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
210000000628 antibody-producing cell Anatomy 0.000 description 2
239000004599 antimicrobial Substances 0.000 description 2
239000003963 antioxidant agent Substances 0.000 description 2
235000006708 antioxidants Nutrition 0.000 description 2
239000003816 antisense DNA Substances 0.000 description 2
239000000074 antisense oligonucleotide Substances 0.000 description 2
238000012230 antisense oligonucleotides Methods 0.000 description 2
239000008365 aqueous carrier Substances 0.000 description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 2
239000011324 bead Substances 0.000 description 2
MMIMIFULGMZVPO-UHFFFAOYSA-N benzyl 3-bromo-2,6-dinitro-5-phenylmethoxybenzoate Chemical compound [O-][N+](=O)C1=C(C(=O)OCC=2C=CC=CC=2)C([N+](=O)[O-])=C(Br)C=C1OCC1=CC=CC=C1 MMIMIFULGMZVPO-UHFFFAOYSA-N 0.000 description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
MDKCFLQDBWCQCV-UHFFFAOYSA-N benzyl isothiocyanate Chemical compound S=C=NCC1=CC=CC=C1 MDKCFLQDBWCQCV-UHFFFAOYSA-N 0.000 description 2
JGSARLDLIJGVTE-MBNYWOFBSA-M benzylpenicillin(1-) Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-M 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
238000004166 bioassay Methods 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
210000001185 bone marrow Anatomy 0.000 description 2
230000024279 bone resorption Effects 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
235000011148 calcium chloride Nutrition 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
229910000389 calcium phosphate Inorganic materials 0.000 description 2
235000011010 calcium phosphates Nutrition 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
238000004113 cell culture Methods 0.000 description 2
230000010261 cell growth Effects 0.000 description 2
230000008859 change Effects 0.000 description 2
235000012000 cholesterol Nutrition 0.000 description 2
ZYVSOIYQKUDENJ-WKSBCEQHSA-N chromomycin A3 Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@@H]1OC(C)=O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O[C@@H]3O[C@@H](C)[C@H](OC(C)=O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@@H]1C[C@@H](O)[C@@H](OC)[C@@H](C)O1 ZYVSOIYQKUDENJ-WKSBCEQHSA-N 0.000 description 2
238000010367 cloning Methods 0.000 description 2
238000000975 co-precipitation Methods 0.000 description 2
229940047120 colony stimulating factors Drugs 0.000 description 2
230000002860 competitive effect Effects 0.000 description 2
230000009918 complex formation Effects 0.000 description 2
238000009833 condensation Methods 0.000 description 2
230000005494 condensation Effects 0.000 description 2
238000010276 construction Methods 0.000 description 2
238000004132 cross linking Methods 0.000 description 2
238000002425 crystallisation Methods 0.000 description 2
230000008025 crystallization Effects 0.000 description 2
229960004397 cyclophosphamide Drugs 0.000 description 2
229960000684 cytarabine Drugs 0.000 description 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
230000001086 cytosolic effect Effects 0.000 description 2
231100000433 cytotoxic Toxicity 0.000 description 2
230000001472 cytotoxic effect Effects 0.000 description 2
238000000502 dialysis Methods 0.000 description 2
NLORYLAYLIXTID-ISLYRVAYSA-N diethylstilbestrol diphosphate Chemical compound C=1C=C(OP(O)(O)=O)C=CC=1C(/CC)=C(\CC)C1=CC=C(OP(O)(O)=O)C=C1 NLORYLAYLIXTID-ISLYRVAYSA-N 0.000 description 2
229960003668 docetaxel Drugs 0.000 description 2
ZWAOHEXOSAUJHY-ZIYNGMLESA-N doxifluridine Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ZWAOHEXOSAUJHY-ZIYNGMLESA-N 0.000 description 2
229950005454 doxifluridine Drugs 0.000 description 2
229950011487 enocitabine Drugs 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
229960001842 estramustine Drugs 0.000 description 2
FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 description 2
229940011871 estrogen Drugs 0.000 description 2
239000000262 estrogen Substances 0.000 description 2
230000001747 exhibiting effect Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000013604 expression vector Substances 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
108700024553 fms Genes Proteins 0.000 description 2
125000000524 functional group Chemical group 0.000 description 2
108010074605 gamma-Globulins Proteins 0.000 description 2
229960002963 ganciclovir Drugs 0.000 description 2
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 2
239000000499 gel Substances 0.000 description 2
230000002068 genetic effect Effects 0.000 description 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
210000003958 hematopoietic stem cell Anatomy 0.000 description 2
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
238000002744 homologous recombination Methods 0.000 description 2
230000006801 homologous recombination Effects 0.000 description 2
229930195733 hydrocarbon Natural products 0.000 description 2
150000002430 hydrocarbons Chemical class 0.000 description 2
229960001330 hydroxycarbamide Drugs 0.000 description 2
230000000148 hypercalcaemia Effects 0.000 description 2
208000030915 hypercalcemia disease Diseases 0.000 description 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
229960001101 ifosfamide Drugs 0.000 description 2
HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 2
150000002466 imines Chemical class 0.000 description 2
230000016784 immunoglobulin production Effects 0.000 description 2
239000002955 immunomodulating agent Substances 0.000 description 2
229940121354 immunomodulator Drugs 0.000 description 2
239000007943 implant Substances 0.000 description 2
238000011065 in-situ storage Methods 0.000 description 2
230000002779 inactivation Effects 0.000 description 2
230000006698 induction Effects 0.000 description 2
239000003701 inert diluent Substances 0.000 description 2
229940125396 insulin Drugs 0.000 description 2
230000002452 interceptive effect Effects 0.000 description 2
229960001388 interferon-beta Drugs 0.000 description 2
229940047124 interferons Drugs 0.000 description 2
230000003902 lesion Effects 0.000 description 2
125000005647 linker group Chemical group 0.000 description 2
239000007791 liquid phase Substances 0.000 description 2
230000007774 longterm Effects 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000004949 mass spectrometry Methods 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
230000010534 mechanism of action Effects 0.000 description 2
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
229960001428 mercaptopurine Drugs 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
229960000485 methotrexate Drugs 0.000 description 2
239000000693 micelle Substances 0.000 description 2
244000005700 microbiome Species 0.000 description 2
230000003278 mimic effect Effects 0.000 description 2
229960005485 mitobronitol Drugs 0.000 description 2
210000005088 multinucleated cell Anatomy 0.000 description 2
210000001721 multinucleated osteoclast Anatomy 0.000 description 2
238000002703 mutagenesis Methods 0.000 description 2
231100000350 mutagenesis Toxicity 0.000 description 2
239000005445 natural material Substances 0.000 description 2
VFEDRRNHLBGPNN-UHFFFAOYSA-N nimustine Chemical compound CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 VFEDRRNHLBGPNN-UHFFFAOYSA-N 0.000 description 2
229960001420 nimustine Drugs 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 description 2
230000036963 noncompetitive effect Effects 0.000 description 2
210000004940 nucleus Anatomy 0.000 description 2
210000000056 organ Anatomy 0.000 description 2
201000002528 pancreatic cancer Diseases 0.000 description 2
208000008443 pancreatic carcinoma Diseases 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
239000002245 particle Substances 0.000 description 2
230000001575 pathological effect Effects 0.000 description 2
230000007170 pathology Effects 0.000 description 2
239000001814 pectin Substances 0.000 description 2
235000010987 pectin Nutrition 0.000 description 2
229920001277 pectin Polymers 0.000 description 2
229960000482 pethidine Drugs 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
OJUGVDODNPJEEC-UHFFFAOYSA-N phenylglyoxal Chemical compound O=CC(=O)C1=CC=CC=C1 OJUGVDODNPJEEC-UHFFFAOYSA-N 0.000 description 2
150000003904 phospholipids Chemical class 0.000 description 2
102000020233 phosphotransferase Human genes 0.000 description 2
229940109328 photofrin Drugs 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
239000006187 pill Substances 0.000 description 2
229920000656 polylysine Polymers 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
229960001586 procarbazine hydrochloride Drugs 0.000 description 2
229940002612 prodrug Drugs 0.000 description 2
239000000651 prodrug Substances 0.000 description 2
230000000069 prophylactic effect Effects 0.000 description 2
230000006916 protein interaction Effects 0.000 description 2
NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 2
230000004044 response Effects 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
238000002821 scintillation proximity assay Methods 0.000 description 2
150000003335 secondary amines Chemical class 0.000 description 2
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 2
229960000553 somatostatin Drugs 0.000 description 2
241000894007 species Species 0.000 description 2
ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 description 2
PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 description 2
210000004988 splenocyte Anatomy 0.000 description 2
239000007921 spray Substances 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
238000003860 storage Methods 0.000 description 2
210000002536 stromal cell Anatomy 0.000 description 2
238000010254 subcutaneous injection Methods 0.000 description 2
239000007929 subcutaneous injection Substances 0.000 description 2
125000001424 substituent group Chemical group 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
239000006188 syrup Substances 0.000 description 2
235000020357 syrup Nutrition 0.000 description 2
NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 2
229960004231 thymalfasin Drugs 0.000 description 2
239000012096 transfection reagent Substances 0.000 description 2
230000032258 transport Effects 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
238000003160 two-hybrid assay Methods 0.000 description 2
125000002233 tyrosyl group Chemical group 0.000 description 2
241000701161 unidentified adenovirus Species 0.000 description 2
241001430294 unidentified retrovirus Species 0.000 description 2
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 2
229960004528 vincristine Drugs 0.000 description 2
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 2
239000013603 viral vector Substances 0.000 description 2
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 2
WDQLRUYAYXDIFW-RWKIJVEZSA-N (2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1 WDQLRUYAYXDIFW-RWKIJVEZSA-N 0.000 description 1
OPCHFPHZPIURNA-MFERNQICSA-N (2s)-2,5-bis(3-aminopropylamino)-n-[2-(dioctadecylamino)acetyl]pentanamide Chemical compound CCCCCCCCCCCCCCCCCCN(CC(=O)NC(=O)[C@H](CCCNCCCN)NCCCN)CCCCCCCCCCCCCCCCCC OPCHFPHZPIURNA-MFERNQICSA-N 0.000 description 1
KYBXNPIASYUWLN-WUCPZUCCSA-N (2s)-5-hydroxypyrrolidine-2-carboxylic acid Chemical compound OC1CC[C@@H](C(O)=O)N1 KYBXNPIASYUWLN-WUCPZUCCSA-N 0.000 description 1
OMJKFYKNWZZKTK-POHAHGRESA-N (5z)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide Chemical compound CN(C)N\N=C1/N=CN=C1C(N)=O OMJKFYKNWZZKTK-POHAHGRESA-N 0.000 description 1
WVWOOAYQYLJEFD-UHFFFAOYSA-N 1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol Chemical compound C1=CN=C([N+]([O-])=O)N1CC(O)CN1CCCCC1 WVWOOAYQYLJEFD-UHFFFAOYSA-N 0.000 description 1
RUAUPNFNQOGIFF-UHFFFAOYSA-N 1-(4-tert-butyl-2,5-dimethoxyphenyl)propan-2-amine Chemical compound COC1=CC(C(C)(C)C)=C(OC)C=C1CC(C)N RUAUPNFNQOGIFF-UHFFFAOYSA-N 0.000 description 1
OEWYWFJWBZNJJG-UHFFFAOYSA-N 1-(aziridin-1-yl)-3-(2-nitroimidazol-1-yl)propan-2-ol Chemical compound C1=CN=C([N+]([O-])=O)N1CC(O)CN1CC1 OEWYWFJWBZNJJG-UHFFFAOYSA-N 0.000 description 1
RYCNUMLMNKHWPZ-SNVBAGLBSA-N 1-acetyl-sn-glycero-3-phosphocholine Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C RYCNUMLMNKHWPZ-SNVBAGLBSA-N 0.000 description 1
VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 1
MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 description 1
LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 1
KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 description 1
FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
YIYCUMYWGOOSNU-FMZZOXHWSA-N 2-[[(2s)-1-[(2s,3s)-2-[[(2s,3r)-2-[[2-[[(2s)-2-amino-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]acetic acid Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O YIYCUMYWGOOSNU-FMZZOXHWSA-N 0.000 description 1
125000000979 2-amino-2-oxoethyl group Chemical group [H]C([*])([H])C(=O)N([H])[H] 0.000 description 1
XPBJPGMCFKYBBV-UHFFFAOYSA-N 2-bromoethyl-[2-hydroxy-3-(2-nitroimidazol-1-yl)propyl]azanium;bromide Chemical compound Br.BrCCNCC(O)CN1C=CN=C1[N+]([O-])=O XPBJPGMCFKYBBV-UHFFFAOYSA-N 0.000 description 1
JQPFYXFVUKHERX-UHFFFAOYSA-N 2-hydroxy-2-cyclohexen-1-one Natural products OC1=CCCCC1=O JQPFYXFVUKHERX-UHFFFAOYSA-N 0.000 description 1
MHIITNFQDPFSES-UHFFFAOYSA-N 25,26,27,28-tetrazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1(25),2,4,6,8(27),9,11,13,15,17,19,21,23-tridecaene Chemical class N1C(C=C2C3=CC=CC=C3C(C=C3NC(=C4)C=C3)=N2)=CC=C1C=C1C=CC4=N1 MHIITNFQDPFSES-UHFFFAOYSA-N 0.000 description 1
NFJMWGFHZFBGJQ-LQDDAWAPSA-M 3,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;bromide Chemical compound [Br-].CCCCCCCC\C=C/CCCCCCCC(=O)OC(CC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC NFJMWGFHZFBGJQ-LQDDAWAPSA-M 0.000 description 1
NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
NUGLIYXAARVRPQ-UHFFFAOYSA-N 3-(2-nitroimidazol-1-yl)propane-1,2-diol Chemical compound OCC(O)CN1C=CN=C1[N+]([O-])=O NUGLIYXAARVRPQ-UHFFFAOYSA-N 0.000 description 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
DHMYGZIEILLVNR-UHFFFAOYSA-N 5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione;1h-pyrimidine-2,4-dione Chemical compound O=C1C=CNC(=O)N1.O=C1NC(=O)C(F)=CN1C1OCCC1 DHMYGZIEILLVNR-UHFFFAOYSA-N 0.000 description 1
229940117976 5-hydroxylysine Drugs 0.000 description 1
NKGPJODWTZCHGF-KQYNXXCUSA-N 6-thioinosinic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(S)=C2N=C1 NKGPJODWTZCHGF-KQYNXXCUSA-N 0.000 description 1
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
XZWXFWBHYRFLEF-FSPLSTOPSA-N Ala-His Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 XZWXFWBHYRFLEF-FSPLSTOPSA-N 0.000 description 1
IPWKGIFRRBGCJO-IMJSIDKUSA-N Ala-Ser Chemical compound C[C@H]([NH3+])C(=O)N[C@@H](CO)C([O-])=O IPWKGIFRRBGCJO-IMJSIDKUSA-N 0.000 description 1
YYAVDNKUWLAFCV-ACZMJKKPSA-N Ala-Ser-Gln Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O YYAVDNKUWLAFCV-ACZMJKKPSA-N 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
MXPOCMVWFLDDLZ-NSCUHMNNSA-N Apaziquone Chemical compound CN1C(\C=C\CO)=C(CO)C(C2=O)=C1C(=O)C=C2N1CC1 MXPOCMVWFLDDLZ-NSCUHMNNSA-N 0.000 description 1
QYLJIYOGHRGUIH-CIUDSAMLSA-N Arg-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCNC(N)=N QYLJIYOGHRGUIH-CIUDSAMLSA-N 0.000 description 1
102220618023 Arginine-glutamic acid dipeptide repeats protein_V78K_mutation Human genes 0.000 description 1
208000002109 Argyria Diseases 0.000 description 1
206010003445 Ascites Diseases 0.000 description 1
PTNFNTOBUDWHNZ-GUBZILKMSA-N Asn-Arg-Met Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(O)=O PTNFNTOBUDWHNZ-GUBZILKMSA-N 0.000 description 1
MECFLTFREHAZLH-ACZMJKKPSA-N Asn-Glu-Cys Chemical compound C(CC(=O)O)[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CC(=O)N)N MECFLTFREHAZLH-ACZMJKKPSA-N 0.000 description 1
KHCNTVRVAYCPQE-CIUDSAMLSA-N Asn-Lys-Asn Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O KHCNTVRVAYCPQE-CIUDSAMLSA-N 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
108090001008 Avidin Proteins 0.000 description 1
WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 description 1
108010070075 Bacteriochlorophyll A Proteins 0.000 description 1
VGGGPCQERPFHOB-UHFFFAOYSA-N Bestatin Natural products CC(C)CC(C(O)=O)NC(=O)C(O)C(N)CC1=CC=CC=C1 VGGGPCQERPFHOB-UHFFFAOYSA-N 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 1
108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical class CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 description 1
102100032937 CD40 ligand Human genes 0.000 description 1
108010001789 Calcitonin Receptors Proteins 0.000 description 1
102100038520 Calcitonin receptor Human genes 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
101710167917 Carbonic anhydrase 2 Proteins 0.000 description 1
102100024633 Carbonic anhydrase 2 Human genes 0.000 description 1
SHHKQEUPHAENFK-UHFFFAOYSA-N Carboquone Chemical compound O=C1C(C)=C(N2CC2)C(=O)C(C(COC(N)=O)OC)=C1N1CC1 SHHKQEUPHAENFK-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
102000011632 Caseins Human genes 0.000 description 1
108010076119 Caseins Proteins 0.000 description 1
229920002101 Chitin Polymers 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
229920002567 Chondroitin Polymers 0.000 description 1
229920001287 Chondroitin sulfate Polymers 0.000 description 1
108020004705 Codon Proteins 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
102000000989 Complement System Proteins Human genes 0.000 description 1
108010069112 Complement System Proteins Proteins 0.000 description 1
108020004394 Complementary RNA Proteins 0.000 description 1
238000011537 Coomassie blue staining Methods 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
241000699802 Cricetulus griseus Species 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
150000008574 D-amino acids Chemical class 0.000 description 1
102000052510 DNA-Binding Proteins Human genes 0.000 description 1
108700020911 DNA-Binding Proteins Proteins 0.000 description 1
102220569345 Deoxynucleotidyltransferase terminal-interacting protein 1_Q20A_mutation Human genes 0.000 description 1
RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
206010014733 Endometrial cancer Diseases 0.000 description 1
102000004533 Endonucleases Human genes 0.000 description 1
108010042407 Endonucleases Proteins 0.000 description 1
241000792859 Enema Species 0.000 description 1
101000759376 Escherichia phage Mu Tail sheath protein Proteins 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
108010087819 Fc receptors Proteins 0.000 description 1
102000009109 Fc receptors Human genes 0.000 description 1
108010008177 Fd immunoglobulins Proteins 0.000 description 1
206010017076 Fracture Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
YNNXQZDEOCYJJL-CIUDSAMLSA-N Gln-Arg-Asp Chemical compound C(C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CCC(=O)N)N)CN=C(N)N YNNXQZDEOCYJJL-CIUDSAMLSA-N 0.000 description 1
WQWMZOIPXWSZNE-WDSKDSINSA-N Gln-Asp-Gly Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O WQWMZOIPXWSZNE-WDSKDSINSA-N 0.000 description 1
102000006395 Globulins Human genes 0.000 description 1
108010044091 Globulins Proteins 0.000 description 1
YYOBUPFZLKQUAX-FXQIFTODSA-N Glu-Asn-Glu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O YYOBUPFZLKQUAX-FXQIFTODSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
108010069236 Goserelin Proteins 0.000 description 1
BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 1
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
101100005713 Homo sapiens CD4 gene Proteins 0.000 description 1
101000868215 Homo sapiens CD40 ligand Proteins 0.000 description 1
101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 1
101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 description 1
108010001336 Horseradish Peroxidase Proteins 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
102000026633 IL6 Human genes 0.000 description 1
IOVUXUSIGXCREV-DKIMLUQUSA-N Ile-Leu-Phe Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 IOVUXUSIGXCREV-DKIMLUQUSA-N 0.000 description 1
TUYOFUHICRWDGA-CIUDSAMLSA-N Ile-Met Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@H](C(O)=O)CCSC TUYOFUHICRWDGA-CIUDSAMLSA-N 0.000 description 1
IPFKIGNDTUOFAF-CYDGBPFRSA-N Ile-Val-Arg Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N IPFKIGNDTUOFAF-CYDGBPFRSA-N 0.000 description 1
206010061598 Immunodeficiency Diseases 0.000 description 1
108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
102100022338 Integrin alpha-M Human genes 0.000 description 1
102000000589 Interleukin-1 Human genes 0.000 description 1
108010002352 Interleukin-1 Proteins 0.000 description 1
241000581650 Ivesia Species 0.000 description 1
FADYJNXDPBKVCA-UHFFFAOYSA-N L-Phenylalanyl-L-lysin Natural products NCCCCC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FADYJNXDPBKVCA-UHFFFAOYSA-N 0.000 description 1
108010092694 L-Selectin Proteins 0.000 description 1
125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 description 1
125000000010 L-asparaginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(=O)N([H])[H] 0.000 description 1
125000000415 L-cysteinyl group Chemical group O=C([*])[C@@](N([H])[H])([H])C([H])([H])S[H] 0.000 description 1
125000002061 L-isoleucyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](C([H])([H])[H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 description 1
125000002435 L-phenylalanyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
102000016551 L-selectin Human genes 0.000 description 1
125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 description 1
125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 description 1
108010054278 Lac Repressors Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
102000006835 Lamins Human genes 0.000 description 1
108010047294 Lamins Proteins 0.000 description 1
108090001090 Lectins Proteins 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
240000000599 Lentinula edodes Species 0.000 description 1
HSQGMTRYSIHDAC-BQBZGAKWSA-N Leu-Ala Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C)C(O)=O HSQGMTRYSIHDAC-BQBZGAKWSA-N 0.000 description 1
108090001030 Lipoproteins Proteins 0.000 description 1
102000004895 Lipoproteins Human genes 0.000 description 1
229940124761 MMP inhibitor Drugs 0.000 description 1
241000282553 Macaca Species 0.000 description 1
101710150918 Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 1
206010064912 Malignant transformation Diseases 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
102000018697 Membrane Proteins Human genes 0.000 description 1
IVDYZAAPOLNZKG-KWHRADDSSA-N Mepitiostane Chemical compound O([C@@H]1[C@]2(CC[C@@H]3[C@@]4(C)C[C@H]5S[C@H]5C[C@@H]4CC[C@H]3[C@@H]2CC1)C)C1(OC)CCCC1 IVDYZAAPOLNZKG-KWHRADDSSA-N 0.000 description 1
SGDBTWWWUNNDEQ-UHFFFAOYSA-N Merphalan Chemical compound OC(=O)C(N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-UHFFFAOYSA-N 0.000 description 1
229920001367 Merrifield resin Polymers 0.000 description 1
208000029725 Metabolic bone disease Diseases 0.000 description 1
OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 description 1
MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 description 1
230000004988 N-glycosylation Effects 0.000 description 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Chemical group CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
QAADZYUXQLUXFX-UHFFFAOYSA-N N-phenylmethylthioformamide Natural products S=CNCC1=CC=CC=C1 QAADZYUXQLUXFX-UHFFFAOYSA-N 0.000 description 1
125000000729 N-terminal amino-acid group Chemical group 0.000 description 1
101710204212 Neocarzinostatin Proteins 0.000 description 1
206010029174 Nerve compression Diseases 0.000 description 1
108091092724 Noncoding DNA Proteins 0.000 description 1
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
108020005187 Oligonucleotide Probes Proteins 0.000 description 1
102000015636 Oligopeptides Human genes 0.000 description 1
108010038807 Oligopeptides Proteins 0.000 description 1
108700026244 Open Reading Frames Proteins 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
208000010191 Osteitis Deformans Diseases 0.000 description 1
208000001132 Osteoporosis Diseases 0.000 description 1
208000027868 Paget disease Diseases 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
239000005662 Paraffin oil Substances 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
108010057150 Peplomycin Proteins 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
FADYJNXDPBKVCA-STQMWFEESA-N Phe-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 FADYJNXDPBKVCA-STQMWFEESA-N 0.000 description 1
KIQUCMUULDXTAZ-HJOGWXRNSA-N Phe-Tyr-Tyr Chemical compound N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O KIQUCMUULDXTAZ-HJOGWXRNSA-N 0.000 description 1
241000364051 Pima Species 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004365 Protease Substances 0.000 description 1
108010029485 Protein Isoforms Proteins 0.000 description 1
102000001708 Protein Isoforms Human genes 0.000 description 1
108091030071 RNAI Proteins 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
102000010498 Receptor Activator of Nuclear Factor-kappa B Human genes 0.000 description 1
108010038036 Receptor Activator of Nuclear Factor-kappa B Proteins 0.000 description 1
208000001647 Renal Insufficiency Diseases 0.000 description 1
108091028664 Ribonucleotide Proteins 0.000 description 1
108010039491 Ricin Proteins 0.000 description 1
238000011579 SCID mouse model Methods 0.000 description 1
208000004337 Salivary Gland Neoplasms Diseases 0.000 description 1
206010061934 Salivary gland cancer Diseases 0.000 description 1
229920002305 Schizophyllan Polymers 0.000 description 1
241000222480 Schizophyllum Species 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
QMCDMHWAKMUGJE-IHRRRGAJSA-N Ser-Phe-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(O)=O QMCDMHWAKMUGJE-IHRRRGAJSA-N 0.000 description 1
DKGRNFUXVTYRAS-UBHSHLNASA-N Ser-Ser-Trp Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O DKGRNFUXVTYRAS-UBHSHLNASA-N 0.000 description 1
241000700584 Simplexvirus Species 0.000 description 1
206010041067 Small cell lung cancer Diseases 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
108010090804 Streptavidin Proteins 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
108010055044 Tetanus Toxin Proteins 0.000 description 1
241000248384 Tetrahymena thermophila Species 0.000 description 1
NYTOUQBROMCLBJ-UHFFFAOYSA-N Tetranitromethane Chemical compound [O-][N+](=O)C([N+]([O-])=O)([N+]([O-])=O)[N+]([O-])=O NYTOUQBROMCLBJ-UHFFFAOYSA-N 0.000 description 1
FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 1
DSGIVWSDDRDJIO-ZXXMMSQZSA-N Thr-Thr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O DSGIVWSDDRDJIO-ZXXMMSQZSA-N 0.000 description 1
108010034949 Thyroglobulin Proteins 0.000 description 1
102000009843 Thyroglobulin Human genes 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
101710162629 Trypsin inhibitor Proteins 0.000 description 1
229940122618 Trypsin inhibitor Drugs 0.000 description 1
102100040247 Tumor necrosis factor Human genes 0.000 description 1
101710097161 Tumor necrosis factor ligand superfamily member 11 Proteins 0.000 description 1
VNYDHJARLHNEGA-RYUDHWBXSA-N Tyr-Pro Chemical compound C([C@H](N)C(=O)N1[C@@H](CCC1)C(O)=O)C1=CC=C(O)C=C1 VNYDHJARLHNEGA-RYUDHWBXSA-N 0.000 description 1
108091023045 Untranslated Region Proteins 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
206010047741 Vulval cancer Diseases 0.000 description 1
208000004354 Vulvar Neoplasms Diseases 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
CWRILEGKIAOYKP-SSDOTTSWSA-M [(2r)-3-acetyloxy-2-hydroxypropyl] 2-aminoethyl phosphate Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCCN CWRILEGKIAOYKP-SSDOTTSWSA-M 0.000 description 1
DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 1
RHMGLWRUEHECOF-UHFFFAOYSA-N [N].N(=O)NC(=O)N Chemical compound [N].N(=O)NC(=O)N RHMGLWRUEHECOF-UHFFFAOYSA-N 0.000 description 1
SINKQSZYJSQJHN-UHFFFAOYSA-N [Sn].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 Chemical compound [Sn].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 SINKQSZYJSQJHN-UHFFFAOYSA-N 0.000 description 1
230000001594 aberrant effect Effects 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
USZYSDMBJDPRIF-SVEJIMAYSA-N aclacinomycin A Chemical compound O([C@H]1[C@@H](O)C[C@@H](O[C@H]1C)O[C@H]1[C@H](C[C@@H](O[C@H]1C)O[C@H]1C[C@]([C@@H](C2=CC=3C(=O)C4=CC=CC(O)=C4C(=O)C=3C(O)=C21)C(=O)OC)(O)CC)N(C)C)[C@H]1CCC(=O)[C@H](C)O1 USZYSDMBJDPRIF-SVEJIMAYSA-N 0.000 description 1
229960004176 aclarubicin Drugs 0.000 description 1
229930183665 actinomycin Natural products 0.000 description 1
RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
230000010933 acylation Effects 0.000 description 1
238000005917 acylation reaction Methods 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
238000009098 adjuvant therapy Methods 0.000 description 1
239000008272 agar Substances 0.000 description 1
229940023476 agar Drugs 0.000 description 1
235000010419 agar Nutrition 0.000 description 1
230000004931 aggregating effect Effects 0.000 description 1
239000003570 air Substances 0.000 description 1
108010070944 alanylhistidine Proteins 0.000 description 1
150000001299 aldehydes Chemical group 0.000 description 1
229940072056 alginate Drugs 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
230000000735 allogeneic effect Effects 0.000 description 1
230000003281 allosteric effect Effects 0.000 description 1
125000000266 alpha-aminoacyl group Chemical group 0.000 description 1
230000004075 alteration Effects 0.000 description 1
229940037003 alum Drugs 0.000 description 1
210000001132 alveolar macrophage Anatomy 0.000 description 1
150000001409 amidines Chemical group 0.000 description 1
238000003277 amino acid sequence analysis Methods 0.000 description 1
229960003896 aminopterin Drugs 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
239000003098 androgen Substances 0.000 description 1
230000002280 anti-androgenic effect Effects 0.000 description 1
230000001093 anti-cancer Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
239000000051 antiandrogen Substances 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
229940041181 antineoplastic drug Drugs 0.000 description 1
239000003101 antineoplastic hormone agonist and antagonist Substances 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
210000003567 ascitic fluid Anatomy 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
229940009098 aspartate Drugs 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
230000035578 autophosphorylation Effects 0.000 description 1
238000011888 autopsy Methods 0.000 description 1
210000003719 b-lymphocyte Anatomy 0.000 description 1
ZSERVQBSOBTXFV-DHHJBRQQSA-M bacteriochlorophyll a Chemical compound C1([C@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@@H](CC)[C@@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ZSERVQBSOBTXFV-DHHJBRQQSA-M 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
210000002469 basement membrane Anatomy 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
125000002619 bicyclic group Chemical group 0.000 description 1
230000001588 bifunctional effect Effects 0.000 description 1
108091008324 binding proteins Proteins 0.000 description 1
229920002988 biodegradable polymer Polymers 0.000 description 1
239000004621 biodegradable polymer Substances 0.000 description 1
230000008827 biological function Effects 0.000 description 1
239000012620 biological material Substances 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
229920001222 biopolymer Polymers 0.000 description 1
201000000053 blastoma Diseases 0.000 description 1
239000002981 blocking agent Substances 0.000 description 1
230000008499 blood brain barrier function Effects 0.000 description 1
230000036770 blood supply Effects 0.000 description 1
210000001218 blood-brain barrier Anatomy 0.000 description 1
238000009835 boiling Methods 0.000 description 1
210000002798 bone marrow cell Anatomy 0.000 description 1
210000004271 bone marrow stromal cell Anatomy 0.000 description 1
210000002805 bone matrix Anatomy 0.000 description 1
230000034127 bone morphogenesis Effects 0.000 description 1
229940112869 bone morphogenetic protein Drugs 0.000 description 1
229940098773 bovine serum albumin Drugs 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
229950004398 broxuridine Drugs 0.000 description 1
229960002092 busulfan Drugs 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
YZLHHTXFNFAZIO-UHFFFAOYSA-I calcium trisodium pentaacetate Chemical compound C(C)(=O)[O-].C(C)(=O)[O-].C(C)(=O)[O-].C(C)(=O)[O-].C(C)(=O)[O-].[Na+].[Na+].[Na+].[Ca+2] YZLHHTXFNFAZIO-UHFFFAOYSA-I 0.000 description 1
239000007894 caplet Substances 0.000 description 1
229960001631 carbomer Drugs 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
229960002115 carboquone Drugs 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
150000001244 carboxylic acid anhydrides Chemical class 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
229960005243 carmustine Drugs 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
238000006555 catalytic reaction Methods 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
238000000423 cell based assay Methods 0.000 description 1
230000032823 cell division Effects 0.000 description 1
230000007910 cell fusion Effects 0.000 description 1
230000006037 cell lysis Effects 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
230000030570 cellular localization Effects 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229960000541 cetyl alcohol Drugs 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
230000009920 chelation Effects 0.000 description 1
239000013043 chemical agent Substances 0.000 description 1
238000001311 chemical methods and process Methods 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
239000012829 chemotherapy agent Substances 0.000 description 1
DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
229940059329 chondroitin sulfate Drugs 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
238000012875 competitive assay Methods 0.000 description 1
238000005094 computer simulation Methods 0.000 description 1
230000001268 conjugating effect Effects 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000002385 cottonseed oil Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
239000012531 culture fluid Substances 0.000 description 1
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
OILAIQUEIWYQPH-UHFFFAOYSA-N cyclohexane-1,2-dione Chemical compound O=C1CCCCC1=O OILAIQUEIWYQPH-UHFFFAOYSA-N 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
229940104302 cytosine Drugs 0.000 description 1
229960003901 dacarbazine Drugs 0.000 description 1
229960000640 dactinomycin Drugs 0.000 description 1
230000006240 deamidation Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000010511 deprotection reaction Methods 0.000 description 1
MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 description 1
229960000633 dextran sulfate Drugs 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000010586 diagram Methods 0.000 description 1
150000005690 diesters Chemical class 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
FFYPMLJYZAEMQB-UHFFFAOYSA-N diethyl pyrocarbonate Chemical compound CCOC(=O)OC(=O)OCC FFYPMLJYZAEMQB-UHFFFAOYSA-N 0.000 description 1
230000029087 digestion Effects 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000006471 dimerization reaction Methods 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Chemical group CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical compound C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
239000000890 drug combination Substances 0.000 description 1
238000009510 drug design Methods 0.000 description 1
238000012912 drug discovery process Methods 0.000 description 1
229940126534 drug product Drugs 0.000 description 1
238000002651 drug therapy Methods 0.000 description 1
230000004821 effect on bone Effects 0.000 description 1
238000004520 electroporation Methods 0.000 description 1
201000008184 embryoma Diseases 0.000 description 1
238000004836 empirical method Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
230000012202 endocytosis Effects 0.000 description 1
239000006274 endogenous ligand Substances 0.000 description 1
230000002357 endometrial effect Effects 0.000 description 1
239000007920 enema Substances 0.000 description 1
229940095399 enema Drugs 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
WCDWBPCFGJXFJZ-UHFFFAOYSA-N etanidazole Chemical compound OCCNC(=O)CN1C=CN=C1[N+]([O-])=O WCDWBPCFGJXFJZ-UHFFFAOYSA-N 0.000 description 1
229950006566 etanidazole Drugs 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
CEIPQQODRKXDSB-UHFFFAOYSA-N ethyl 3-(6-hydroxynaphthalen-2-yl)-1H-indazole-5-carboximidate dihydrochloride Chemical compound Cl.Cl.C1=C(O)C=CC2=CC(C3=NNC4=CC=C(C=C43)C(=N)OCC)=CC=C21 CEIPQQODRKXDSB-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
230000005713 exacerbation Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
238000001400 expression cloning Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
238000001914 filtration Methods 0.000 description 1
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
238000002875 fluorescence polarization Methods 0.000 description 1
239000007850 fluorescent dye Substances 0.000 description 1
238000001215 fluorescent labelling Methods 0.000 description 1
239000006260 foam Substances 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
229960000297 fosfestrol Drugs 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
230000005714 functional activity Effects 0.000 description 1
238000002825 functional assay Methods 0.000 description 1
235000021255 galacto-oligosaccharides Nutrition 0.000 description 1
150000003271 galactooligosaccharides Chemical class 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000007897 gelcap Substances 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
230000009368 gene silencing by RNA Effects 0.000 description 1
108091006104 gene-regulatory proteins Proteins 0.000 description 1
102000034356 gene-regulatory proteins Human genes 0.000 description 1
238000010353 genetic engineering Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
208000005017 glioblastoma Diseases 0.000 description 1
229930195712 glutamate Natural products 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
230000002414 glycolytic effect Effects 0.000 description 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 1
229960002913 goserelin Drugs 0.000 description 1
230000002440 hepatic effect Effects 0.000 description 1
206010073071 hepatocellular carcinoma Diseases 0.000 description 1
125000005842 heteroatom Chemical group 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
238000001794 hormone therapy Methods 0.000 description 1
102000054751 human RUNX1T1 Human genes 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000000852 hydrogen donor Substances 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
230000033444 hydroxylation Effects 0.000 description 1
238000005805 hydroxylation reaction Methods 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
230000003100 immobilizing effect Effects 0.000 description 1
210000002865 immune cell Anatomy 0.000 description 1
239000012642 immune effector Substances 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000005847 immunogenicity Effects 0.000 description 1
238000001114 immunoprecipitation Methods 0.000 description 1
238000000126 in silico method Methods 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000006882 induction of apoptosis Effects 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
150000002484 inorganic compounds Chemical class 0.000 description 1
229910010272 inorganic material Inorganic materials 0.000 description 1
102000006495 integrins Human genes 0.000 description 1
108010044426 integrins Proteins 0.000 description 1
230000008611 intercellular interaction Effects 0.000 description 1
230000004068 intracellular signaling Effects 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000001038 ionspray mass spectrometry Methods 0.000 description 1
108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
239000008101 lactose Substances 0.000 description 1
210000005053 lamin Anatomy 0.000 description 1
239000002523 lectin Substances 0.000 description 1
210000005240 left ventricle Anatomy 0.000 description 1
108010071185 leucyl-alanine Proteins 0.000 description 1
108010044056 leucyl-phenylalanine Proteins 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
108091005446 macrophage receptors Proteins 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
230000036212 malign transformation Effects 0.000 description 1
230000003211 malignant effect Effects 0.000 description 1
239000000845 maltitol Substances 0.000 description 1
235000010449 maltitol Nutrition 0.000 description 1
229940035436 maltitol Drugs 0.000 description 1
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
208000027202 mammary Paget disease Diseases 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
229960001855 mannitol Drugs 0.000 description 1
SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
229960001924 melphalan Drugs 0.000 description 1
229950009246 mepitiostane Drugs 0.000 description 1
230000037323 metabolic rate Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
RMAHPRNLQIRHIJ-UHFFFAOYSA-N methyl carbamimidate Chemical compound COC(N)=N RMAHPRNLQIRHIJ-UHFFFAOYSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
NEGQCMNHXHSFGU-UHFFFAOYSA-N methyl pyridine-2-carboximidate Chemical compound COC(=N)C1=CC=CC=N1 NEGQCMNHXHSFGU-UHFFFAOYSA-N 0.000 description 1
230000011987 methylation Effects 0.000 description 1
238000007069 methylation reaction Methods 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 1
229960000282 metronidazole Drugs 0.000 description 1
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
238000000520 microinjection Methods 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
208000027361 mineral metabolism disease Diseases 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
231100000324 minimal toxicity Toxicity 0.000 description 1
OBBCSXFCDPPXOL-UHFFFAOYSA-N misonidazole Chemical compound COCC(O)CN1C=CN=C1[N+]([O-])=O OBBCSXFCDPPXOL-UHFFFAOYSA-N 0.000 description 1
229950010514 misonidazole Drugs 0.000 description 1
210000003470 mitochondria Anatomy 0.000 description 1
230000011278 mitosis Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000006011 modification reaction Methods 0.000 description 1
239000003607 modifier Substances 0.000 description 1
238000012900 molecular simulation Methods 0.000 description 1
ZFRKLDBGVWUUEE-UHFFFAOYSA-N n,n-dimethyl-1-phenylmethanamine;hydrate Chemical compound [OH-].C[NH+](C)CC1=CC=CC=C1 ZFRKLDBGVWUUEE-UHFFFAOYSA-N 0.000 description 1
NCLWMRHNDKORFM-UHFFFAOYSA-N n-benzyl-n-methylhydroxylamine Chemical compound CN(O)CC1=CC=CC=C1 NCLWMRHNDKORFM-UHFFFAOYSA-N 0.000 description 1
SHDMMLFAFLZUEV-UHFFFAOYSA-N n-methyl-1,1-diphenylmethanamine Chemical compound C=1C=CC=CC=1C(NC)C1=CC=CC=C1 SHDMMLFAFLZUEV-UHFFFAOYSA-N 0.000 description 1
230000017095 negative regulation of cell growth Effects 0.000 description 1
QZGIWPZCWHMVQL-UIYAJPBUSA-N neocarzinostatin chromophore Chemical compound O1[C@H](C)[C@H](O)[C@H](O)[C@@H](NC)[C@H]1O[C@@H]1C/2=C/C#C[C@H]3O[C@@]3([C@@H]3OC(=O)OC3)C#CC\2=C[C@H]1OC(=O)C1=C(O)C=CC2=C(C)C=C(OC)C=C12 QZGIWPZCWHMVQL-UIYAJPBUSA-N 0.000 description 1
210000005170 neoplastic cell Anatomy 0.000 description 1
230000001613 neoplastic effect Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
210000000440 neutrophil Anatomy 0.000 description 1
239000002547 new drug Substances 0.000 description 1
229910052759 nickel Inorganic materials 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
230000000683 nonmetastatic effect Effects 0.000 description 1
238000011580 nude mouse model Methods 0.000 description 1
XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 description 1
229960002378 oftasceine Drugs 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229940124276 oligodeoxyribonucleotide Drugs 0.000 description 1
239000002751 oligonucleotide probe Substances 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
201000008482 osteoarthritis Diseases 0.000 description 1
230000001599 osteoclastic effect Effects 0.000 description 1
210000004409 osteocyte Anatomy 0.000 description 1
229940043515 other immunoglobulins in atc Drugs 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
238000004091 panning Methods 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
230000005298 paramagnetic effect Effects 0.000 description 1
238000004810 partition chromatography Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
QIMGFXOHTOXMQP-GFAGFCTOSA-N peplomycin Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCCN[C@@H](C)C=1C=CC=CC=1)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C QIMGFXOHTOXMQP-GFAGFCTOSA-N 0.000 description 1
229950003180 peplomycin Drugs 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
210000005259 peripheral blood Anatomy 0.000 description 1
239000011886 peripheral blood Substances 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000008180 pharmaceutical surfactant Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
150000008300 phosphoramidites Chemical class 0.000 description 1
238000002428 photodynamic therapy Methods 0.000 description 1
238000000206 photolithography Methods 0.000 description 1
IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
238000000053 physical method Methods 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
229950010456 pimonidazole Drugs 0.000 description 1
108010054442 polyalanine Proteins 0.000 description 1
125000003367 polycyclic group Chemical group 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920002704 polyhistidine Polymers 0.000 description 1
229930001119 polyketide Natural products 0.000 description 1
125000000830 polyketide group Chemical group 0.000 description 1
229930001118 polyketide hybrid Natural products 0.000 description 1
125000003308 polyketide hybrid group Chemical group 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920005990 polystyrene resin Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
238000010837 poor prognosis Methods 0.000 description 1
239000005373 porous glass Substances 0.000 description 1
230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
230000004481 post-translational protein modification Effects 0.000 description 1
230000001323 posttranslational effect Effects 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000003380 propellant Substances 0.000 description 1
AOHJOMMDDJHIJH-UHFFFAOYSA-N propylenediamine Chemical compound CC(N)CN AOHJOMMDDJHIJH-UHFFFAOYSA-N 0.000 description 1
230000004952 protein activity Effects 0.000 description 1
230000012846 protein folding Effects 0.000 description 1
238000009163 protein therapy Methods 0.000 description 1
230000002797 proteolythic effect Effects 0.000 description 1
230000006337 proteolytic cleavage Effects 0.000 description 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 1
239000011589 pyridoxal 5'-phosphate Substances 0.000 description 1
229960001327 pyridoxal phosphate Drugs 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
230000006340 racemization Effects 0.000 description 1
238000000763 radioactive isotope labeling Methods 0.000 description 1
239000002287 radioligand Substances 0.000 description 1
230000010837 receptor-mediated endocytosis Effects 0.000 description 1
238000003259 recombinant expression Methods 0.000 description 1
230000007115 recruitment Effects 0.000 description 1
239000006215 rectal suppository Substances 0.000 description 1
238000006722 reduction reaction Methods 0.000 description 1
230000009703 regulation of cell differentiation Effects 0.000 description 1
230000020404 regulation of osteoclast differentiation Effects 0.000 description 1
230000037425 regulation of transcription Effects 0.000 description 1
239000003488 releasing hormone Substances 0.000 description 1
229930002330 retinoic acid Natural products 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
239000002336 ribonucleotide Substances 0.000 description 1
XMVJITFPVVRMHC-UHFFFAOYSA-N roxarsone Chemical class OC1=CC=C([As](O)(O)=O)C=C1[N+]([O-])=O XMVJITFPVVRMHC-UHFFFAOYSA-N 0.000 description 1
230000022932 ruffle assembly Effects 0.000 description 1
238000013341 scale-up Methods 0.000 description 1
238000013391 scatchard analysis Methods 0.000 description 1
238000007423 screening assay Methods 0.000 description 1
238000010845 search algorithm Methods 0.000 description 1
208000011581 secondary neoplasm Diseases 0.000 description 1
230000028327 secretion Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000002864 sequence alignment Methods 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
210000001599 sigmoid colon Anatomy 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
230000011664 signaling Effects 0.000 description 1
238000004088 simulation Methods 0.000 description 1
208000000587 small cell lung carcinoma Diseases 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
229940126586 small molecule drug Drugs 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
239000001540 sodium lactate Substances 0.000 description 1
229940005581 sodium lactate Drugs 0.000 description 1
235000011088 sodium lactate Nutrition 0.000 description 1
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
238000001899 southwestern blot Methods 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
229940063673 spermidine Drugs 0.000 description 1
229940063675 spermine Drugs 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
102000009076 src-Family Kinases Human genes 0.000 description 1
108010087686 src-Family Kinases Proteins 0.000 description 1
238000007447 staining method Methods 0.000 description 1
238000012289 standard assay Methods 0.000 description 1
229940032147 starch Drugs 0.000 description 1
210000000130 stem cell Anatomy 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
229940014800 succinic anhydride Drugs 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
238000001308 synthesis method Methods 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
229940061532 tegafur / uracil Drugs 0.000 description 1
229940118376 tetanus toxin Drugs 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
229960001196 thiotepa Drugs 0.000 description 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
229960002175 thyroglobulin Drugs 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
QVMPZNRFXAKISM-UHFFFAOYSA-N tirapazamine Chemical compound C1=CC=C2[N+]([O-])=NC(=N)N(O)C2=C1 QVMPZNRFXAKISM-UHFFFAOYSA-N 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
108091007466 transmembrane glycoproteins Proteins 0.000 description 1
102000027257 transmembrane receptors Human genes 0.000 description 1
108091008578 transmembrane receptors Proteins 0.000 description 1
238000011277 treatment modality Methods 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
229960001727 tretinoin Drugs 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
230000005740 tumor formation Effects 0.000 description 1
208000025421 tumor of uterus Diseases 0.000 description 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
108010020532 tyrosyl-proline Proteins 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
229940035893 uracil Drugs 0.000 description 1
206010046766 uterine cancer Diseases 0.000 description 1
210000003934 vacuole Anatomy 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
229960004355 vindesine Drugs 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
201000005102 vulva cancer Diseases 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
238000001262 western blot Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
238000003158 yeast two-hybrid assay Methods 0.000 description 1
238000001086 yeast two-hybrid system Methods 0.000 description 1
229960002555 zidovudine Drugs 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229950009268 zinostatin Drugs 0.000 description 1
XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
229940002005 zometa Drugs 0.000 description 1

Images

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

CNA2003801088289A 2002-11-15 2003-11-17 防止和治疗癌转移以及与癌转移相关的骨质损失的方法 Pending CN1787837A (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42678102P	2002-11-15	2002-11-15
US60/426,781		2002-11-15

Publications (1)

Publication Number	Publication Date
CN1787837A true CN1787837A (zh)	2006-06-14

Family

ID=32326424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CNA2003801088289A Pending CN1787837A (zh)	2002-11-15	2003-11-17	防止和治疗癌转移以及与癌转移相关的骨质损失的方法

Country Status (14)

Country	Link
EP (3)	EP1572106B1 (pt)
JP (2)	JP4727992B2 (pt)
CN (1)	CN1787837A (pt)
AT (1)	ATE466885T1 (pt)
AU (1)	AU2003291002A1 (pt)
CA (1)	CA2505994A1 (pt)
CY (1)	CY1110305T1 (pt)
DE (1)	DE60332483D1 (pt)
DK (1)	DK1572106T3 (pt)
ES (1)	ES2345885T3 (pt)
IL (3)	IL168531A (pt)
PT (1)	PT1572106E (pt)
SI (1)	SI1572106T1 (pt)
WO (1)	WO2004045532A2 (pt)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106573061A (zh) *	2014-04-30	2017-04-19	佩德罗巴里德拉玛泽康德德费诺萨基金会	药剂、制品和用途
TWI595005B (zh) *	2007-08-21	2017-08-11	安健股份有限公司	人類ｃ－ｆｍｓ抗原結合蛋白質
CN109970852A (zh) *	2019-04-01	2019-07-05	浙江大学	分泌抗狂犬病毒m蛋白单克隆抗体的杂交瘤细胞株及应用
CN111053903A (zh) *	2019-12-26	2020-04-24	深圳市纳诺艾医疗科技有限公司	一种携带共振原子的核酸类似物的化合物的应用

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7108852B2 (en)	2000-03-20	2006-09-19	Warner-Lambert Company Llc	Methods of treating inflammation using antibodies to M-CSF
CN1787837A (zh)	2002-11-15	2006-06-14	希龙公司	防止和治疗癌转移以及与癌转移相关的骨质损失的方法
AR045563A1 (es) *	2003-09-10	2005-11-02	Warner Lambert Co	Anticuerpos dirigidos a m-csf
PL2311873T3 (pl) *	2004-01-07	2019-01-31	Novartis Vaccines And Diagnostics, Inc.	Przeciwciało monoklonalne specyficzne wobec M-CSF i jego zastosowania
EP1706137A2 (en) *	2004-01-21	2006-10-04	Chiron Corporation	M-csf muteins and uses thereof
US20060024677A1 (en) *	2004-07-20	2006-02-02	Morris David W	Novel therapeutic targets in cancer
WO2006096489A2 (en) *	2005-03-08	2006-09-14	Pharmacia & Upjohn Company Llc	Anti-m-csf antibody compositions having reduced levels of endotoxin
AR054233A1 (es) *	2005-03-08	2007-06-13	Pharmacia & Upjohn Co Llc	Composiciones de anticuerpos igg2
EP2311876A3 (en) *	2005-07-28	2011-04-27	Novartis AG	M-CSF-specific monoclonal antibody and uses thereof
EP1913028B1 (en) *	2005-07-28	2015-03-04	Novartis AG	Use of antibody to m-csf
EP1977238B1 (en) *	2005-12-22	2016-09-28	Novartis AG	Soluble human m-csf receptor and uses thereof
US20090246208A1 (en) *	2006-01-05	2009-10-01	Novartis Ag	Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
US8080246B2 (en)	2008-11-26	2011-12-20	Five Prime Therapeutics, Inc.	Colony stimulating factor 1 receptor (CSF1R) extracellular domain fusion molecules
US8183207B2 (en)	2008-11-26	2012-05-22	Five Prime Therapeutics, Inc.	Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules
SI2949670T1 (sl)	2009-12-10	2019-05-31	F. Hoffmann-La Roche Ag	Protitelesa, ki se preferenčno vežejo na zunajcelično domeno 4 človeškega CSF1R, in njihova uporaba
US9221910B2 (en)	2010-03-05	2015-12-29	Hoffmann-La Roche Inc.	Antibodies against human CSF-1R
BR112012020372A8 (pt)	2010-03-05	2018-01-02	Hoffmann La Roche	anticorpo que se liga ao csf-1r humano, composição farmacêutica, ácido nucleico, vetores de expressão, célula hospedeira e método para a produção de um anticorpo recombinante
AR080698A1 (es)	2010-04-01	2012-05-02	Imclone Llc	Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e
RS58211B1 (sr)	2010-05-04	2019-03-29	Five Prime Therapeutics Inc	Antitela koja vezuju csf1r
ES2618828T3 (es)	2011-07-18	2017-06-22	The University Of Melbourne	Uso de antagonistas de c-Fms
WO2013057290A1 (en)	2011-10-21	2013-04-25	INSERM (Institut National de la Santé et de la Recherche Médicale)	A m-dc8+ monocyte depleting agent for the prevention or the treatment of a condition associated with a chronic hyperactivation of the immune system
KR20140113683A (ko)	2011-12-15	2014-09-24	에프. 호프만-라 로슈 아게	인간 csf-1r에 대한 항체 및 이의 용도
US9452215B2 (en)	2012-02-22	2016-09-27	The Regents Of The University Of Colorado	Bourvadin derivatives and therapeutic uses thereof
EP2817004B1 (en)	2012-02-22	2018-04-11	The Regents of The University of Colorado, A Body Corporate	Bouvardin derivatives and therapeutic uses thereof
AR090263A1 (es)	2012-03-08	2014-10-29	Hoffmann La Roche	Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
US20130302322A1 (en)	2012-05-11	2013-11-14	Five Prime Therapeutics, Inc.	Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
RU2718751C2 (ru)	2012-08-31	2020-04-14	Файв Прайм Терапьютикс, Инк.	Способы лечения патологических состояний антителами, которые связываются с рецептором колониестимулирующего фактора 1 (csf1r)
JP5799048B2 (ja) *	2013-03-26	2015-10-21	株式会社三共	遊技機
JP2016516092A (ja)	2013-04-12	2016-06-02	モルフォシス・アー・ゲー	Ｍ−ｃｓｆを標的とする抗体
AR095882A1 (es)	2013-04-22	2015-11-18	Hoffmann La Roche	Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
AR097584A1 (es)	2013-09-12	2016-03-23	Hoffmann La Roche	Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano
JOP20200094A1 (ar)	2014-01-24	2017-06-16	Dana Farber Cancer Inst Inc	جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar)	2014-01-31	2017-06-16	Children’S Medical Center Corp	جزيئات جسم مضاد لـ tim-3 واستخداماتها
SI3116909T1 (sl)	2014-03-14	2020-03-31	Novartis Ag	Molekule protiteles na LAG-3 in njih uporaba
EP3157957A1 (en)	2014-06-23	2017-04-26	Five Prime Therapeutics, Inc.	Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
MA41044A (fr)	2014-10-08	2017-08-15	Novartis Ag	Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
CA2964367C (en)	2014-10-14	2024-01-30	Novartis Ag	Antibody molecules to pd-l1 and uses thereof
SMT202100164T1 (it)	2014-10-29	2021-05-07	Bristol Myers Squibb Co	Terapia di combinazione per il cancro
EP3233918A1 (en)	2014-12-19	2017-10-25	Novartis AG	Combination therapies
JP6797801B2 (ja)	2014-12-22	2020-12-09	ファイヴプライムセラピューティクスインク	Ｐｖｎｓを治療するための抗ｃｓｆ１ｒ抗体
EP3268035A4 (en)	2015-03-10	2018-10-31	Aduro Biotech, Inc.	Compositions and methods for activating "stimulator of interferon gene" -dependent signalling
CA2980460A1 (en)	2015-04-13	2016-10-20	Five Prime Therapeutics, Inc.	Combination therapy for cancer
EP3108897A1 (en)	2015-06-24	2016-12-28	F. Hoffmann-La Roche AG	Antibodies against human csf-1r for use in inducing lymphocytosis in lymphomas or leukemias
PL3317301T3 (pl)	2015-07-29	2021-11-15	Novartis Ag	Terapie skojarzone zawierające cząsteczki przeciwciał przeciw lag-3
WO2017019896A1 (en)	2015-07-29	2017-02-02	Novartis Ag	Combination therapies comprising antibody molecules to pd-1
US20180207273A1 (en)	2015-07-29	2018-07-26	Novartis Ag	Combination therapies comprising antibody molecules to tim-3
BR112018008867A8 (pt)	2015-11-03	2019-02-26	Janssen Biotech Inc	anticorpos que se ligam especificamente a pd-1 e seus usos
CA3007671A1 (en)	2015-12-17	2017-06-22	Novartis Ag	Antibody molecules to pd-1 and uses thereof
EP3507367A4 (en)	2016-07-05	2020-03-25	Aduro BioTech, Inc.	CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
WO2018036852A1 (en)	2016-08-25	2018-03-01	F. Hoffmann-La Roche Ag	Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent
CN110072553B (zh)	2016-12-22	2023-09-15	豪夫迈·罗氏有限公司	在抗pd-l1/pd1治疗失败之后抗csf-1r抗体与抗pd-l1抗体组合对肿瘤的治疗
UY37695A (es)	2017-04-28	2018-11-30	Novartis Ag	Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
EP3642240A1 (en)	2017-06-22	2020-04-29	Novartis AG	Antibody molecules to cd73 and uses thereof
CR20190593A (es)	2017-06-22	2020-05-10	Novartis Ag	Moléculas de anticuerpo que se unen a cd73 y usos de las mismas
TWI808092B (zh)	2017-08-30	2023-07-11	中國大陸商北京軒義醫藥科技有限公司	作為干擾素基因調節劑之刺激劑的環狀二核苷酸
BR112020004879A2 (pt)	2017-09-13	2020-09-15	Five Prime Therapeutics, Inc.	métodos para tratar o câncer pancreático, para tratar o câncer e para determinar a responsividade de um sujeito com câncer
CN111655288A (zh)	2017-11-16	2020-09-11	诺华股份有限公司	组合疗法
UY38247A (es)	2018-05-30	2019-12-31	Novartis Ag	Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
US20210214459A1 (en)	2018-05-31	2021-07-15	Novartis Ag	Antibody molecules to cd73 and uses thereof
AR116109A1 (es)	2018-07-10	2021-03-31	Novartis Ag	Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
MX2021007392A (es)	2018-12-20	2021-08-24	Novartis Ag	Regimen de dosificacion y combinacion farmaceutica que comprende derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona.
EA202192019A1 (ru)	2019-02-15	2021-11-02	Новартис Аг	Производные 3-(1-оксо-5-(пиперидин-4-ил)изоиндолин-2-ил)пиперидин-2,6-диона и пути их применения
ES2982474T3 (es)	2019-02-15	2024-10-16	Novartis Ag	Derivados de 3-(1-oxoisoindolin-2-il)piperidin-1,6-diona sustituidos y usos de estos
JP2022548881A (ja)	2019-09-18	2022-11-22	ノバルティスアーゲー	Ｅｎｔｐｄ２抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
US20230056470A1 (en)	2019-12-20	2023-02-23	Novartis Ag	Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases
MX2022015852A (es)	2020-06-23	2023-01-24	Novartis Ag	Regimen de dosificacion que comprende derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona.
EP4188549A1 (en)	2020-08-03	2023-06-07	Novartis AG	Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CA3195020A1 (en) *	2020-10-07	2022-04-14	Samuel GENIER	Live biotherapeutics secreting synthetic bacteriophages in the treatment of cancer
TW202304979A (zh)	2021-04-07	2023-02-01	瑞士商諾華公司	抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
AR125874A1 (es)	2021-05-18	2023-08-23	Novartis Ag	Terapias de combinación

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5491065A (en) *	1989-02-10	1996-02-13	Cetus Oncology Corporation	Monoclonal antibodies that bind to and neutralize dimeric but not monomeric human M-CSF and methods of use thereof for detection of dimeric M-CSF

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4179337A (en)	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
US4816567A (en)	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
US5019369A (en)	1984-10-22	1991-05-28	Vestar, Inc.	Method of targeting tumors in humans
US6103224A (en) *	1985-02-05	2000-08-15	Chiron Corporation	N∇2 CSF-1 (short form) and carboxy truncated fragments thereof
US4847201A (en)	1985-02-05	1989-07-11	Cetus Corporation	DNA encoding for CSF-1 and accompanying recombinant systems
US5057313A (en)	1986-02-25	1991-10-15	The Center For Molecular Medicine And Immunology	Diagnostic and therapeutic antibody conjugates
US4902505A (en)	1986-07-30	1990-02-20	Alkermes	Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US5567610A (en)	1986-09-04	1996-10-22	Bioinvent International Ab	Method of producing human monoclonal antibodies and kit therefor
US5032676A (en)	1986-10-14	1991-07-16	Immunex Corporation	Nonglycosylated analogs of human colony stimulating factors
US4987071A (en)	1986-12-03	1991-01-22	University Patents, Inc.	RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5116742A (en)	1986-12-03	1992-05-26	University Patents, Inc.	RNA ribozyme restriction endoribonucleases and methods
US4837028A (en)	1986-12-24	1989-06-06	Liposome Technology, Inc.	Liposomes with enhanced circulation time
US4929700A (en)	1987-04-16	1990-05-29	Cetus Corporation	Production of purified, biologically active, bacterially produced recombinant human CSF-1
US4904582A (en)	1987-06-11	1990-02-27	Synthetic Genetics	Novel amphiphilic nucleic acid conjugates
US4892538A (en)	1987-11-17	1990-01-09	Brown University Research Foundation	In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5283187A (en)	1987-11-17	1994-02-01	Brown University Research Foundation	Cell culture-containing tubular capsule produced by co-extrusion
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
GB8823869D0 (en)	1988-10-12	1988-11-16	Medical Res Council	Production of antibodies
US5175384A (en)	1988-12-05	1992-12-29	Genpharm International	Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
DE3920358A1 (de)	1989-06-22	1991-01-17	Behringwerke Ag	Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
GB8915572D0 (en)	1989-07-07	1989-08-23	Natural Environment Res	Use of bluetongue virus proteins as vaccine components
WO1991010741A1 (en)	1990-01-12	1991-07-25	Cell Genesys, Inc.	Generation of xenogeneic antibodies
US5283173A (en)	1990-01-24	1994-02-01	The Research Foundation Of State University Of New York	System to detect protein-protein interactions
US5229275A (en)	1990-04-26	1993-07-20	Akzo N.V.	In-vitro method for producing antigen-specific human monoclonal antibodies
US5723286A (en)	1990-06-20	1998-03-03	Affymax Technologies N.V.	Peptide library and screening systems
GB9014932D0 (en)	1990-07-05	1990-08-22	Celltech Ltd	Recombinant dna product and method
GB9015198D0 (en)	1990-07-10	1990-08-29	Brien Caroline J O	Binding substance
US5650554A (en)	1991-02-22	1997-07-22	Sembiosys Genetics Inc.	Oil-body proteins as carriers of high-value peptides in plants
JP3417558B2 (ja)	1991-05-10	2003-06-16	ジェネンテク，インコーポレイテッド	配位子作用薬および拮抗薬の選択
US5565332A (en)	1991-09-23	1996-10-15	Medical Research Council	Production of chimeric antibodies - a combinatorial approach
US5733731A (en)	1991-10-16	1998-03-31	Affymax Technologies N.V.	Peptide library and screening method
US5270170A (en)	1991-10-16	1993-12-14	Affymax Technologies N.V.	Peptide library and screening method
ATE297465T1 (de)	1991-11-25	2005-06-15	Enzon Inc	Verfahren zur herstellung von multivalenten antigenbindenden proteinen
WO1993016177A1 (en)	1992-02-11	1993-08-19	Cell Genesys, Inc.	Homogenotization of gene-targeting events
US5573905A (en)	1992-03-30	1996-11-12	The Scripps Research Institute	Encoded combinatorial chemical libraries
WO1993024640A2 (en)	1992-06-04	1993-12-09	The Regents Of The University Of California	Methods and compositions for in vivo gene therapy
ES2301158T3 (es)	1992-07-24	2008-06-16	Amgen Fremont Inc.	Produccion de anticuerpos xenogenicos.
JP3628713B2 (ja)	1993-06-07	2005-03-16	帝國製薬株式会社	生理学的に活性なペプチドを含有する膣投与製剤
US5585277A (en)	1993-06-21	1996-12-17	Scriptgen Pharmaceuticals, Inc.	Screening method for identifying ligands for target proteins
US5922545A (en)	1993-10-29	1999-07-13	Affymax Technologies N.V.	In vitro peptide and antibody display libraries
US5443953A (en)	1993-12-08	1995-08-22	Immunomedics, Inc.	Preparation and use of immunoconjugates
AU1662595A (en)	1994-01-28	1995-08-15	Herbert Altmann	Method of determining the activity of a regulatory factor, and use of the method
US6054287A (en)	1994-05-27	2000-04-25	Methodist Hospital Of Indiana, Inc.	Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species
US20020111461A1 (en)	1999-05-21	2002-08-15	Todd C. Somers	Low molecular weight peptidomimetic growth hormone secretagogues
US6130364A (en)	1995-03-29	2000-10-10	Abgenix, Inc.	Production of antibodies using Cre-mediated site-specific recombination
CA2761116A1 (en)	1995-04-27	1996-10-31	Amgen Fremont Inc.	Human antibodies derived from immunized xenomice
CA2219486A1 (en)	1995-04-28	1996-10-31	Abgenix, Inc.	Human antibodies derived from immunized xenomice
US6025146A (en)	1995-06-05	2000-02-15	Chiron Corporation	Identification of M-CSF agonists and antagonists
GB9518220D0 (en)	1995-09-06	1995-11-08	Medical Res Council	Checkpoint gene
GB9712818D0 (en)	1996-07-08	1997-08-20	Cambridge Antibody Tech	Labelling and selection of specific binding molecules
DE69718341T2 (de)	1996-10-08	2003-10-30	U-Bisys B.V., Utrecht	Verfahren und mittel zur auswahl von peptiden und proteinen mit spezifischer affinität zu einem zielmolekül
EP2305027B1 (en)	1996-12-03	2014-07-02	Amgen Fremont Inc.	Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
US6017757A (en)	1997-02-20	2000-01-25	Mississippi State University	Isolated viable nematode intestinal cells
US6306393B1 (en)	1997-03-24	2001-10-23	Immunomedics, Inc.	Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US20020032315A1 (en)	1997-08-06	2002-03-14	Manuel Baca	Anti-vegf antibodies
AU1804499A (en) *	1997-12-05	1999-06-28	La Jolla Institute For Experimental Medicine	Inhibition of tumor growth by macrophage intervention
US20020029391A1 (en)	1998-04-15	2002-03-07	Claude Geoffrey Davis	Epitope-driven human antibody production and gene expression profiling
CN1214043C (zh)	1998-12-01	2005-08-10	蛋白质设计实验室股份有限公司	抗γ－干扰素的人化抗体
EP1223980B1 (de)	1999-10-28	2003-05-21	Hofbauer, Reinhold	Verwendung von csf-1-inhibitoren
US7560534B2 (en)	2000-05-08	2009-07-14	Celldex Research Corporation	Molecular conjugates comprising human monoclonal antibodies to dendritic cells
PT1354034E (pt)	2000-11-30	2008-02-28	Medarex Inc	Roedores transgénicos transcromossómicos para produção de anticorpos humanos
US20030199531A1 (en)	2001-07-19	2003-10-23	Todd Wipke	YIGSR peptidomimetics and methods for using the same
AU2003220525A1 (en)	2002-03-29	2003-10-20	Abgenix, Inc.	Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same
US20030198965A1 (en)	2002-04-19	2003-10-23	Isis Pharmaceuticals Inc.	Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression
CN1787837A (zh)	2002-11-15	2006-06-14	希龙公司	防止和治疗癌转移以及与癌转移相关的骨质损失的方法

2003
- 2003-11-17 CN CNA2003801088289A patent/CN1787837A/zh active Pending
- 2003-11-17 DK DK03783587.3T patent/DK1572106T3/da active
- 2003-11-17 CA CA002505994A patent/CA2505994A1/en not_active Abandoned
- 2003-11-17 ES ES03783587T patent/ES2345885T3/es not_active Expired - Lifetime
- 2003-11-17 EP EP03783587A patent/EP1572106B1/en not_active Expired - Lifetime
- 2003-11-17 WO PCT/US2003/036679 patent/WO2004045532A2/en active Application Filing
- 2003-11-17 PT PT03783587T patent/PT1572106E/pt unknown
- 2003-11-17 AT AT03783587T patent/ATE466885T1/de active
- 2003-11-17 AU AU2003291002A patent/AU2003291002A1/en not_active Abandoned
- 2003-11-17 SI SI200331835T patent/SI1572106T1/sl unknown
- 2003-11-17 EP EP10004581A patent/EP2246363A1/en not_active Withdrawn
- 2003-11-17 DE DE60332483T patent/DE60332483D1/de not_active Expired - Lifetime
- 2003-11-17 EP EP10178225.8A patent/EP2287192B1/en not_active Revoked
- 2003-11-17 JP JP2004553807A patent/JP4727992B2/ja not_active Expired - Lifetime
2005
- 2005-05-11 IL IL168531A patent/IL168531A/en not_active IP Right Cessation
2009
- 2009-05-21 IL IL198884A patent/IL198884A/en not_active IP Right Cessation
2010
- 2010-04-11 IL IL204987A patent/IL204987A/en not_active IP Right Cessation
- 2010-07-20 CY CY20101100680T patent/CY1110305T1/el unknown
- 2010-10-12 JP JP2010230108A patent/JP2011006488A/ja not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5491065A (en) *	1989-02-10	1996-02-13	Cetus Oncology Corporation	Monoclonal antibodies that bind to and neutralize dimeric but not monomeric human M-CSF and methods of use thereof for detection of dimeric M-CSF

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MACINO ET AL.:: "Breast cancer increases osteoclastogenesis bysecretingM-CSF and upregulating RANKL in stromal cells.", J.SURGICAL RES.100 *
SUSAN D. NEALE ET AL.: "Macrophage Colony-Stimulating Factor and Interleukin-6 Release by Periprosthetic Cells Stimulates Osteoclast Formation and Bone Resorption", 《JOURNAL OF ORTHOPAEDIC RESEARCH》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI595005B (zh) *	2007-08-21	2017-08-11	安健股份有限公司	人類ｃ－ｆｍｓ抗原結合蛋白質
CN106573061A (zh) *	2014-04-30	2017-04-19	佩德罗巴里德拉玛泽康德德费诺萨基金会	药剂、制品和用途
CN109970852A (zh) *	2019-04-01	2019-07-05	浙江大学	分泌抗狂犬病毒m蛋白单克隆抗体的杂交瘤细胞株及应用
CN109970852B (zh) *	2019-04-01	2020-10-13	浙江大学	分泌抗狂犬病毒m蛋白单克隆抗体的杂交瘤细胞株及应用
CN111053903A (zh) *	2019-12-26	2020-04-24	深圳市纳诺艾医疗科技有限公司	一种携带共振原子的核酸类似物的化合物的应用

Also Published As

Publication number	Publication date
EP1572106B1 (en)	2010-05-05
IL198884A (en)	2013-10-31
SI1572106T1 (sl)	2010-08-31
ATE466885T1 (de)	2010-05-15
EP1572106A2 (en)	2005-09-14
PT1572106E (pt)	2010-06-17
CY1110305T1 (el)	2015-01-14
JP2006519163A (ja)	2006-08-24
EP1572106A4 (en)	2007-06-13
EP2246363A1 (en)	2010-11-03
DE60332483D1 (de)	2010-06-17
ES2345885T3 (es)	2010-10-05
AU2003291002A1 (en)	2004-06-15
IL198884A0 (en)	2011-08-01
IL204987A (en)	2015-02-26
WO2004045532A2 (en)	2004-06-03
IL204987A0 (en)	2011-08-01
EP2287192B1 (en)	2015-08-26
AU2003291002A8 (en)	2004-06-15
WO2004045532A3 (en)	2006-01-26
IL168531A (en)	2012-08-30
CA2505994A1 (en)	2004-06-03
EP2287192A1 (en)	2011-02-23
JP2011006488A (ja)	2011-01-13
DK1572106T3 (da)	2010-08-23
JP4727992B2 (ja)	2011-07-20

Publication	Publication Date	Title
CN1787837A (zh)	2006-06-14	防止和治疗癌转移以及与癌转移相关的骨质损失的方法
JP6305964B2 (ja)	2018-04-04	Ｉｌ−２２に結合する抗体およびｉｌ−２２ｒに結合する抗体を含む、サイトカインシグナリングに関連する疾患および障害の処置のための組成物および方法
JP5904985B2 (ja)	2016-04-20	免疫調節因子であるｂａｆｆレセプター（ｂｃｍａ）
JP2006519163A5 (pt)	2006-11-16
DK2514436T3 (en)	2018-03-12	IL-22 FOR USE IN TREATMENT OF MICROBIAL DISEASES
EP1223964A1 (en)	2002-07-24	April receptor (bcma) and uses thereof
CN1242809C (zh)	2006-02-22	T－bam(cd40l)技术在制备治疗涉及平滑肌细胞的疾病的药物中的应用
AU2016202280B2 (en)	2017-08-24	Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to IL-22 and IL-22R
TW202426496A (zh)	2024-07-01	特異性識別cd40的抗體及其應用
TW202426497A (zh)	2024-07-01	特異性識別cd40的抗體及其應用
CN1756764A (zh)	2006-04-05	新型蛋白质及其用途
AU2014259514A1 (en)	2014-11-20	Compositions and methods for treatment of microbial disorders

Legal Events

Date	Code	Title	Description
2006-06-14	C06	Publication
2006-06-14	PB01	Publication
2006-08-09	C10	Entry into substantive examination
2006-08-09	SE01	Entry into force of request for substantive examination
2007-02-16	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1092717 Country of ref document: HK
2008-07-02	ASS	Succession or assignment of patent right	Owner name: NOVARTIS VACCINES & DIAGNOSTIC Free format text: FORMER OWNER: CHIRON CORP. Effective date: 20080530
2008-07-02	C41	Transfer of patent application or patent right or utility model
2008-07-02	TA01	Transfer of patent application right	Effective date of registration: 20080530 Address after: Delaware Applicant after: Novartis Vaccines & Diagnostic Inc. Address before: American California Applicant before: Chiron Corporation
2016-03-02	C02	Deemed withdrawal of patent application after publication (patent law 2001)
2016-03-02	WD01	Invention patent application deemed withdrawn after publication	Application publication date: 20060614
2016-06-10	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1092717 Country of ref document: HK