CN1745798A - Pure Chinese medicine formula granules for preventing and treating hypertension and hyperlipidemia and preventing arteriosclerosis - Google Patents

Abstract

A Chinese medicine in the form of particles for preventing and treating hypertension and hyperlipemia and preventing arteriosclerosis is prepared from 9 Chinese-medicinal materials including astragalus root, haw, Chinese angelica root, chrysanthemum flower, etc. Its advantages are high curative effect and no need of decoction.

Description

Pure Chinese medicine formula granules for preventing and treating hypertension and hyperlipidemia and preventing arteriosclerosis

technical field

The invention relates to a traditional Chinese medicine preparation, in particular to a pure Chinese medicinal formula granule preparation for preventing and treating hypertension and hyperlipidemia to prevent arteriosclerosis.

Background technique

The pursuit of quality of life, the prevention and treatment of high blood pressure, hyperlipidemia, prevention of arteriosclerosis, and prolonging life are common wishes and pursuits of people. With the progress of society and the improvement of people's living standards, people's requirements for health and quality of life are getting higher and higher. However, due to changes in lifestyle and living habits, as well as the increasing degree of aging society, the incidence of hypertension, hyperlipidemia, and arteriosclerosis is increasing. In the current field of western medicine, it is difficult to see preparations for prevention, treatment, and health care; in the field of traditional Chinese medicine, there are related ancient secret recipes, which usually need to go through a complicated process of preparing and decocting traditional Chinese medicine, which cannot meet the fast-paced needs of modern people. Living needs; the price of Chinese patent medicine preparations is relatively expensive.

Society calls for a convenient preparation for prevention, treatment and health care.

Contents of the invention

The object of the present invention is to develop a convenient preparation for prevention, treatment and health care.

The technical scheme of the present invention is to develop a pure Chinese medicine formula granule preparation for preventing and treating high blood pressure and hyperlipidemia and preventing arteriosclerosis. : Uncaria 12-18 parts, Astragalus 12-18 parts, Alisma 10-12 parts, raw hawthorn 10-12 parts, cassia seed 9-12 parts, angelica 9-12 parts, kudzu root 6-8 parts, safflower 6-6 parts 8 parts, 6 to 8 parts of chrysanthemum.

The preparation method of the above-mentioned pure Chinese medicine formula granules for preventing and treating hypertension and hyperlipidemia and preventing arteriosclerosis is to mix the above-mentioned dosed Chinese medicine formula granules, and prepare granules according to the traditional Chinese medicine preparation process;

Or the granules of the above-mentioned Chinese medicine formulas, mixed according to the dosage and ready for use.

The application of the above-mentioned pure traditional Chinese medicine formula granules for preventing and treating hypertension and hyperlipidemia and preventing arteriosclerosis is applied in the preparation of Chinese medicine formula granules for preventing and treating hypertension and hyperlipidemia and preventing arteriosclerosis.

The advantages of the present invention are: no decoction, tea brewing for drinking, convenient and easy to implement, and easy to popularize. With just a little effort, you can achieve the effects of lowering blood pressure, lowering blood lipids, preventing arteriosclerosis, regulating the body, curing diseases and strengthening the body, balancing yin and yang, replenishing side effects and remedying disadvantages, and health care; strive to balance blood pressure, eliminate fat and unblock the veins, maintain the body and mind, and strengthen the body. Physical fitness, disease prevention, longevity.

clinical information

Inclusion criteria for hypertension: patients with mild to moderate (grade 1-2) essential hypertension, ie sitting systolic blood pressure (SBP) 140-179mmHg or diastolic blood pressure (DBP) 90-109mmHg. Exclude (1) secondary hypertension; (2) severe hypertension sitting systolic blood pressure (SBP) ≥ 180mmHg or diastolic blood pressure (DBP) ≥ 110mmHg; (3) heart, liver and kidney dysfunction; (4) diabetes patients.

A total of 467 patients with essential hypertension were selected. According to the ratio of 3:1, they were randomly divided into a treatment group and a control group. In the treatment group, 350 cases were male, 245 cases, and female cases were 105 cases. There were 80 males and 37 females, with an average age of 54.6±11.6 years and an average blood pressure of 164.0±7.4/99.0±9.4mmHg.

method

The treatment group took traditional Chinese medicine formula granules (entrusted to Jiangyin Tianjiang Pharmaceutical Co., Ltd. to process), and the composition of the agreed prescription (weight ratio): 12-18 parts of Uncaria, 12-18 parts of Astragalus, 10-12 parts of Alisma, and 10-10 parts of Hawthorn. 12 parts, 9 to 12 parts of cassia seed, 9 to 12 parts of angelica, 6 to 8 parts of kudzu root, 6 to 8 parts of safflower, and 6 to 8 parts of chrysanthemum. Prepare granules according to the traditional Chinese medicine preparation process for the prepared medicinal materials in proportion; or prepare granules according to the traditional Chinese medicine preparation process for the above-mentioned pure medicinal materials, mix according to the proportion, and set aside; the fineness is 100-120 mesh.

How to take: Wash the powder in the bag with 100-150ml of boiling water, and take it warm. 1-2 times a day, the recommended time to take is 8:00 am or 3:00 pm; or take according to your physical condition as directed by your doctor.

The control group took Niuhuang Jiangya Capsules (product of Tianjin Darentang Pharmaceutical Factory), 1.6 grams once a day.

During the treatment, no other antihypertensive drugs were added to the two groups.

result

Efficacy Judgment Antihypertensive Efficacy: According to the drug efficacy index formulated by the Pharmaceutical Administration Bureau of the Ministry of Health of the People's Republic of China in July 1993.

Significant DBP drops ≥ 10mmHg and returns to normal; or SBP drops ≥ 20mmHg;

Effective DBP drops to ≥ 10mmHg but drops to normal; or SBP drops ≥ 10-19mmHg;

Invalid does not meet the above criteria.

       Table 1 Blood pressure results before and after treatment in the treatment group and control group (X±S)

Groups Number of Cases SBP mmHg DBP mmHg

160.0 ± 11.5 97.0 ± 9.3 before the treatment

therapy group

                                                                                                                                                                                                                                                                

117 before treatment 164.0 ± 7.4 99.0 ± 9.4

control group

                                                                                                                                 

Comparison of antihypertensive efficacy between the two groups

348 cases in the treatment group, 104 cases (29.9%) were markedly effective, 207 cases (59.5%) were effective, 37 cases (10.6%) were ineffective, and the total effective rate was 89.4%;

Of the 116 cases in the control group, 52 cases (44.8%) were markedly effective, 30 cases (25.9%) were effective, and 34 cases (29.3%) were ineffective, and the total effective rate was 70.7%;

There was a significant difference between the two groups at P<0.01.

Among the 467 selected patients with essential hypertension, there were 387 cases of dyslipidemia, and we tried the above-mentioned preparations for treatment.

60 cases of the control group (hyperlipidemia caused by diet) took the jujube oral liquid made by the preparation room of the hospital. (250ml mixture made from 20g single jujube)

Blood lipids were measured before and after treatment in both groups, and the results showed that:

Triglyceride (TG), β-lipoprotein (β-LP), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and arteriosclerosis in the treatment group after treatment The index (AI) was significantly different from that before treatment, P<0.01.

In the control group, there was no significant difference between before and after treatment, P<0.05. (See Table 2)

Table 2 Blood lipid measurement results (X±S) ^-C /mmol/1 before and after treatment of the treatment group and the control group

                                                               Period period (n = 60)

Before treatment After treatment After treatment Before treatment After treatment

TG 1.79±0.44 1.38±0.30 1.77±0.38 1.68±0.49

β-LP 5.41±0.60 4.70±0.50 5.49±0.24 5.23±0.51

TC 5.61±0.23 5.13±0.20 5.63±0.41 5.39±0.22

HDL-C 0.39±0.04 0.45±0.03 0.38±0.05 0.40±0.02

LDL-C 1.43±0.64 1.27±0.54 1.47±0.48 1.41±0.36

0.185± 0.2255± 0.1732± 0.1943±

HDL-C/TC

0.1074 0.099 0.1014 0.1084

AI 4.90±3.35 3.70±2.001 4.50±2.962 4.10±2.109

According to the clinical practice of Qingdao Municipal Hospital, this patent application technology has the clinical curative effect of preventing and treating hypertension and hyperlipidemia and preventing arteriosclerosis. Moreover, no liver or kidney damage has been found clinically, no toxic and side effects, no environmental pollution, easy to use, and reliable curative effect.

Typical cases:

Shi XX, male, 59 years old, a cadre, went to the doctor on January 15, 2002. He had suffered from high blood pressure for ten years and had taken western medicine Jiangya tablets for a long time. Clear, low back pain. Blood pressure 160/100mmHg. Two weeks after taking this Chinese medicine formula granule for treatment, the above-mentioned symptoms were alleviated or eliminated. After taking it for two weeks, the symptoms disappeared, and the blood pressure was stable at 120/80mmHg. There was no change in the three-month follow-up.

Liu, female, 52 years old, business worker, went to see a doctor on May 19, 2002, blood lipid test showed: triglyceride (TG) 2.9mmol·L ^-1 β-lipoprotein (β-LP) 6.9mmol·L ^-1 , total cholesterol (TC) 6.6mmol·L ^-1 , high-density lipoprotein (HDL-C) 0.51mmol·L ^-1 , low-density lipoprotein (LDL-C) 2.10mmol·L ^-1 , blood pressure 150/90mmHg. Complaints of dizziness, malaise, lumbago and tinnitus, restless sleep, irritability. Two weeks after taking this Chinese medicine formula granule for treatment, the above-mentioned symptoms were basically eliminated. After taking it for two weeks, the blood lipids were checked again, and the above indexes were all normal, and the blood pressure was stable at 120/70mmHg. Follow-up for three months showed no change.

Detailed ways

Example 1

Medicinal material described in the present invention refers to:

Uncaria (Ramulus Uncariae Cum Uncis), Astragalus (Radix Astragali), Alisma (Raizoma Alismatis), Hawthorn (Fructus Crataregi), Cassia (Semen Cassiae), Angelica (Radix Angelicae), Pueraria (Radix Puerarlae Lobatae), Safflower ( FlosCarthami), Chrysanthemum (Flos Chrysanthemi)

Drug composition: Uncaria 18g, Astragalus 18g, Alisma 12g, hawthorn 12g, cassia seed 12g, angelica 12g, kudzu root 8g, safflower 8g, chrysanthemum 8g.

Preparation method: mix the above-mentioned traditional Chinese medicine formula granules, prepare granules according to the traditional Chinese medicine preparation process, and set aside. The dosage per person is 10-30 grams each time.

Tests show that the preparation of the invention can be used in the preparation of traditional Chinese medicine formula granules for preventing and treating hypertension and hyperlipidemia and preventing arteriosclerosis.

Function: subduing yang and calming pressure, clearing the brain and improving eyesight, promoting blood circulation and removing blood stasis, soothing the mind and calming the nerves.

Indications: Hypertension, hyperlipidemia, atherosclerosis, abnormal blood rheology, cardiovascular and cerebrovascular diseases, dizziness, blurred vision, fatigue and other diseases. Applicable to: various hypertension, hyperlipidemia, atherosclerosis, cardiovascular and cerebrovascular diseases.

Direction of administration: Rinse off the medicinal powder in the bag with 100-150ml of boiling water, and take it warm. 1-2 times a day, the recommended time to take is 8:00 a.m. or 3:00 p.m.; or take according to your physical condition as directed by your doctor.

Note: avoid spicy, salty, tobacco, alcohol. It is forbidden for children, pregnant women and postpartum women. Those with bleeding tendency are forbidden.

Example 2

Drug composition: Uncaria 12g, Astragalus 12g, Alisma 10g, hawthorn 10g, cassia seed 9g, angelica 9g, kudzu root 6g, safflower 6g, chrysanthemum 6g.

The preparation method is to mix the above-mentioned Chinese medicine formula granules according to the dosage and set aside. Others are with embodiment 1.

Example 3

Drug composition: Uncaria 14g, Astragalus 14g, Alisma 10g, hawthorn 10g, cassia seed 10g, angelica 10g, kudzu root 6g, safflower 6g, chrysanthemum 6g. All the other are with embodiment 1.

Example 4

Drug composition: Uncaria 16g, Astragalus 16g, Alisma 11g, hawthorn 11g, cassia seed 11g, angelica 11g, kudzu root 7g, safflower 7g, chrysanthemum 7g. All the other are with embodiment 1.

Claims (4)

1. A pure Chinese medicine formula granule preparation for preventing and treating hypertension and hyperlipidemia to prevent arteriosclerosis, characterized in that, it is made up of the Chinese medicine formula granules of the following weight components: Uncaria 12-18 parts, Radix Astragali 12-18 parts, Alisma alisma 10-12 parts, hawthorn 10-12 parts, cassia seed 9-12 parts, angelica 9-12 parts, kudzu root 6-8 parts, safflower 6-8 parts, chrysanthemum 6-8 parts. 2. according to the preparation method of the pure Chinese medicine formula granule preparation of prevention and treatment of hypertension, hyperlipidemia prevention arteriosclerosis described in claim 1, it is characterized in that, the Chinese medicine formula granule of proportioning, mix, prepare granule by Chinese medicine preparation process. 3. according to the preparation method of the pure Chinese medicine formula granule preparation for preventing and treating hypertension and hyperlipidemia preventing arteriosclerosis according to claim 1, it is characterized in that the dosed Chinese medicine formula granules are mixed evenly for subsequent use. 4. According to the application of the pure Chinese medicine formula granule for preventing and treating hypertension and hyperlipidemia preventing arteriosclerosis according to claim 1, it is characterized in that it is used in the preparation of Chinese medicine formula granules for preventing and treating hypertension and hyperlipidemia preventing arteriosclerosis.