CN1279944C - Medicine for treating cardiocerebral vascular system disease and blood supply deficiency, medicine preparing method and preparation - Google Patents

Abstract

The present invention relates to a medicine for treating cardiocerebral/cardiovascular system diseases and blood supply deficiency, a medicine preparing method and a preparation, which is characterized in that raw medicinal materials are prepared from ganoderma, ginkgo leaf, epimedium herb, kudzuvine root, rhizoma ligustici wallichii, red sage root, hawthorn fruit and earthworm. The medicine can be made into the forms of peroral preparations and injection preparations. The medicine of the present invention has the functions of supplementing Qi, activating blood circulation, dispersing blood stasis, dredging collateral, lowering fat, eliminating thrombus, refreshing the brain and enhancing immunity, and the medicine has the advantages of obvious effect, clinical recovery, high efficiency and obvious long-term therapeutic effect on treating blood supply deficiency and cardiocerebral/cardiovascular system diseases, such as brain trauma, apoplexy (comprising cerebral embolism, cerebral embolism and cerebral hemorrhage), coronary heart disease, hyperlipoidemia, hypertension, arterial sclerosis, diabetes, vasculitis, cervical vertebra hyperostosis, slipped disk, etc.

Description

The medicine, process for preparing medicine and the preparation that are used for the treatment of diseases of cardiovascular and cerebrovascular systems and blood supply insufficiency

Technical field:

The present invention relates to treat medicine, its preparation method and the preparation of cardiovascular and cerebrovascular disease such as cerebral trauma, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, coronary heart disease, hyperlipidemia, hypertension, arteriosclerosis, diabetes, vasculitis, cervical spondylosis hyperosteogeny, intervertebral disk hernia and blood supply insufficiency, belong to the field of Chinese medicines.

Background technology:

In the prior art, for cardiovascular and cerebrovascular disease and blood supply insufficiency treatments such as cerebral trauma, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, coronary heart disease, hyperlipidemia, hypertension, arteriosclerosis, diabetes, vasculitis, cervical spondylosis hyperosteogeny, intervertebral disk hernias, no matter be oral Chinese patent medicine, FUFANG DANSHEN PIAN, BUCHANG NAOXINTONG glue are assisted with Tongxinluo glue and are assisted, or oral western medicine, troxerutin, Thebe woods, the stupid Horizon of nitre, nitrendipine all can only relief of symptoms, late result is poor, and the normal phase of most patient takes medicine and all can't solve the problem of recurrence.

Summary of the invention:

The present invention is for avoiding above-mentioned existing in prior technology weak point, provide a kind of medicine that is used for the treatment of diseases of cardiovascular and cerebrovascular systems and blood supply insufficiency, in the hope of more effectively treating cerebral trauma, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, coronary heart disease, hyperlipidemia, hypertension, arteriosclerosis, diabetes, vasculitis, cervical spondylosis hyperosteogeny, intervertebral disk hernia etc.

The present invention provides the preparation method and the preparation of medicine simultaneously.

The technical scheme that technical solution problem of the present invention is adopted is:

The characteristics of medicine of the present invention are: crude drug by weight consists of: Ganoderma 6～25, Folium Ginkgo 6～30, Herba Epimedii 6～15, Radix Puerariae 6～30, Rhizoma Chuanxiong 6～30, Radix Salviae Miltiorrhizae 6～30, Fructus Crataegi 6～30, Pheretima 5～15.

The characteristics of process for preparing medicine of the present invention are to operate as follows:

A, to take by weighing each crude drug by compatibility standby;

B, get Pheretima, stir-baking with vinegar is concocted; Getting the 30-80% Ganoderma powder is broken into 120 orders and gets the Ganoderma fine powder; Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; Remaining Ganoderma powder is broken into 10 orders and gets the Ganoderma coarse powder, and Ganoderma coarse powder and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi and Pheretima add water 3-8 by weight doubly measures and decoct three times, and the collecting decoction filtration is concentrated into relative density under 80 ℃ and is 1.15 extractum;

C, will merge by each extractum of above-mentioned steps b gained and Ganoderma fine powder, add conventional adjuvant after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

The characteristics of medicine of the present invention are that also crude drug by weight consists of: Ganoderma 6～25, Folium Ginkgo 6～30, Herba Epimedii 6～15, Radix Puerariae 6～30, Rhizoma Chuanxiong 6～30, Radix Salviae Miltiorrhizae 6～30, Fructus Crataegi 6～30, Pheretima 5～1, Hirudo 6～25, Flos Carthami 3～15, Radix Notoginseng 3～15.

The characteristics of the preparation method of medicine of the present invention also are to operate as follows:

A, to take by weighing each crude drug by compatibility standby;

B, get Pheretima, stir-baking with vinegar is concocted; Getting the 30-80% Ganoderma powder is broken into 120 orders and gets the Ganoderma fine powder; Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; The Ganoderma powder of remaining part is broken into 10 orders and gets the Ganoderma coarse powder; Flos Carthami adds 1.7 times of boiling water more than 95 ℃ and overflows bubble and filtered in 1 hour, adds 1.5 times of boiling water more than 95 ℃ for the second time and overflows bubble and filtered in 1 hour, merge Flos Carthami filtrate, separate red flower pesticide slag; Flos Carthami medicinal residues and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, Pheretima, Hirudo, Radix Notoginseng and Ganoderma coarse powder add water 3-8 by weight doubly to be measured and decocts three times, and collecting decoction and Flos Carthami filtrate filter, and is concentrated into relative density under 80 ℃ and is 1.15 extractum;

C, will merge by each extractum of above-mentioned steps b gained and Ganoderma fine powder, add conventional adjuvant after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

The characteristics of medicine of the present invention are that also crude drug by weight consists of: Ganoderma 6～25, Folium Ginkgo 6～30, Herba Epimedii 6～15, Radix Puerariae 6～30, Rhizoma Chuanxiong 6～30, Radix Salviae Miltiorrhizae 6～30, Fructus Crataegi 6～30, Pheretima 5～1, Hirudo 6～25, Flos Carthami 3～15, Radix Notoginseng 3～15, Borneolum Syntheticum 0.1～5.

The characteristics of process for preparing medicine of the present invention also are to operate as follows:

A, to take by weighing each crude drug by compatibility standby;

B, get Pheretima, stir-baking with vinegar is concocted; Getting the 5-40% Ganoderma powder is broken into 120 orders and gets the Ganoderma fine powder; Get Borneolum Syntheticum powder and be broken into 150 order Borneolum Syntheticum fine powders; Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; The remaining part Ganoderma powder is broken into 10 orders and gets Ganoderma coarse powder, Flos Carthami and add 1.7 times of boiling water more than 95 ℃ and overflow bubble and filtered in 1 hour, add for the second time the casual bubble of 1.5 times of boiling water more than 95 ℃ filtered in 1 hour, merge Flos Carthami filtrate, separate red flower pesticide slag, Flos Carthami medicinal residues and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, Pheretima, Hirudo, Radix Notoginseng and Ganoderma coarse powder add water 3-8 by weight and doubly measure decoction three times, collecting decoction and Flos Carthami filtrate filter, and are concentrated into relative density under 80 ℃ and are 1.15 extractum;

C, will merge by each extractum of above-mentioned steps b gained and Ganoderma, Borneolum Syntheticum fine powder, add conventional adjuvant after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

The characteristics of pharmaceutical preparation of the present invention are that its preparation comprises peroral dosage form and injection type.

Angina pectoris is ictal chest pain or the uncomfortable clinical syndrome for main performance of chest that causes myocardium temporary hypoxic-ischemic to cause owing to coronary atherosclerosis and the functional change of coronary artery (spasm).Belong to the traditional Chinese medical science thoracic obstruction, disease category such as pained.

Hypertension is that to increase with arteriotony be the disease of main performance.Belong to disease categories such as Chinese medicine is dizzy, headache.

Hyperlipemia is that to increase with blood plasma lipide concentration be the disease of main clinical manifestation.In blood circulation, blood fat is general to be combined into lipoprotein with the blood apolipoprotein and to participate in turning round and metabolism, so hyperlipemia often is reflected in hyperlipoproteinemia.Belong to the turbid category that waits of traditional Chinese medical science expectorant.

Apoplexy has another name called apoplexy, be with fall forward unexpected dusk, half body by, crooked mouth and tongue, speech stuttering puckery or in silence, hemianesthesia is primary symptom, primary disease is equivalent to the acute cerebrovascular disease of western medicine.

Cervical spondylosis is cervical vertebra and accessory structure degenerative change thereof, a series of clinical symptoms, the body card that stimulate or oppress linked groups to occur.Primary disease belongs to Chinese medicine arthromyodynia, myopathy, headache, category such as dizzy.

At five kinds of diseases of last kind, Ganoderma during medicine of the present invention is formed, sweet, flat.GUIXIN, lung, liver, kidney channel.Invigorating QI and tranquilization, Folium Ginkgo, sweet, bitter, puckery, flat.The GUIXIN warp.Blood circulation promoting and blood stasis dispelling, pain relieving.Herba Epimedii, hot, sweet, warm, return liver, kidney channel, kidney-replenishing, bone and muscle strengthening.Radix Puerariae, sweet, hot, cool.Cure mainly the hypertension neck pain.Rhizoma Chuanxiong, hot, warm.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.The Radix Salviae Miltiorrhizae hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to remove obstruction in the collateral, relieving restlessness clears away heart-fire.Crataegolic acid, sweet.Cure mainly trusted subordinate's twinge, hyperlipemia.Pheretima is salty, cold.Return liver, spleen, urinary bladder channel.The heat clearing away arresting convulsion, collateral dredging.Cure mainly: hypertension, numb limbs and tense tendons, hemiplegia.Each medicine of we all has synergism, has the effect of benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral, blood fat reducing embolism extinguishing, consciousness-restoring and orifice-opening, and can raise immunity.The effect that if can increase Hirudo, Flos Carthami, Radix Notoginseng, Borneolum Syntheticum four Chinese medicine and benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral, blood fat reducing embolism extinguishing, consciousness-restoring and orifice-opening is stronger.Better efficacy.

Have technology to compare with oneself, the present invention is by carrying out compatibility with above-mentioned Chinese medicine, and oneself obtains embodying the beneficial effect that is produced in secular clinical practice:

Medicine: select the capsule preparations of embodiment 1 preparation, every contains 0.4 gram (including crude drug 1.29 grams)

Function: benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral, blood fat reducing embolism extinguishing, consciousness-restoring and orifice-opening.

Cure mainly: chest pain, uncomfortable in chest, shortness of breath and palpitation, soft unable, the numb hand and foot of headache, dizzy, aphasia, facial hemiparalysis, hemiplegia, limb, blurred vision, body of the tongue is light red, thin white fur of tongue, stringy and hesitant pulse.

Therapeutic Method: oral: three times on the one, one time five, one month is a course of treatment.

Case choice criteria and curative effect are judged: formulate (Ministry of Public Health issue in 1993) according to new Chinese medicine clinical research guideline

The tcm syndrome efficacy evaluation

□	Clinic control	Cardinal symptom disappears substantially, and the clinical symptoms integrated value descends 〉=90%.
			□	Produce effects	Main disease is obviously improved, and the clinical symptoms integrated value descends 〉=60%≤89%.
□	Effectively	Cardinal symptom is alleviated to some extent, and the clinical symptoms integrated value descends 〉=30%≤59%.
			□	Invalid	Cardinal symptom does not have obvious improvement, and the clinical symptoms integrated value descends＜30%.

Traditional Chinese medical science individual event symptom curative effect determinate standard

□	Clinic control	Symptom is treated the basic disappearance in back, and the clinical symptoms integrated value descends 〉=90%.
			□	Produce effects	Disease is treated the back and is obviously improved clinical symptoms integrated value decline 〉=60%≤89%.
□	Effectively	Alleviate to some extent after symptom is treated, the clinical symptoms integrated value descends 〉=30%≤59%.
			□	Invalid	Symptom is treated the back does not have obviously improvement, and the clinical symptoms integrated value descends＜30%.

Through controlling angina pectoris 375 examples, wherein clinic control 275 examples, produce effects 63 examples, effective 34 examples, invalid 3 examples.Wherein, clinic control, obvious effective rate reach 90%.

Through controlling hypertension have a headache 225 examples, wherein clinic control 205 examples, produce effects 8 examples, effective 7 examples, invalid 5 examples.Wherein, clinic control, obvious effective rate reach 94.6%.

Through controlling hyperlipemia 357 examples, wherein clinic control 302 examples, produce effects 41 examples, effective 8 examples, invalid 6 examples.Wherein, clinic control, obvious effective rate reach 96%.

Through controlling apoplexy 42 examples, wherein clinic control 9 examples, produce effects 19 examples, effective 10 examples, invalid 4 examples.Wherein, clinic control, obvious effective rate reach 66.66%.

Through treating cervical spondylosis 78 examples, wherein clinic control 25 examples, produce effects 41 examples, effective 8 examples, invalid 4 examples.Wherein, clinic control, obvious effective rate reach 84.6%.

Case 1: Huang Daren, man, prescription on individual diagnosis in 55 years old, 98 years 5 days on the 4th, readme is dizzy, headache, palpitation and restlessness, red tongue, yellow fur, stringy and hesitant pulse.After lipid examination: change of serum C T6.50mmol/L, TG87mmol/L took capsule preparations 15 of the present invention, symptom was clearly better, and symptom all disappears after 30 days.Lipid examination: change of serum C T4.80mmol/L, TG65mmol/L reach the clinic control standard.

Case 2: Li Fayou, man, on October 12nd, 45 years old 1 are gone to a doctor readme chest pain, uncomfortable in chest, shortness of breath and palpitation, light red tongue purple, hesitant pulse.Electrocardiogram S-T section, upright T popin is smooth, and smooth T ripple is inverted.After obeying capsule preparations 10 of the present invention, symptom is clearly better, and symptom is most of after 30 days disappears.It is normal to serve on three months electrocardiograms.Clinic control.So far not See recurrence.

Case 3: go to a doctor next in opening, male, on April 6th, 45 years old 1.The headache of readme hypertension all can not stop outbreak through the multiple Western medicine of informal dress for many years.Take capsule preparations of the present invention, one day three times, one time five, just obtained produce effects in one month, serve on three months clinic control.So far not See headache recurrence.

Case 4: Wang Liwei, man, 59 years old, 97 on Decembers were gone to a doctor in 17.Readme apoplexy half a year, facial hemiparalysis, hemiplegia.Red tongue, hesitant pulse.Take capsule preparations of the present invention, one day three times, one time five, just obtained produce effects in two months, serve on six months clinic control.Can participate in manual labor now.

Case 5: Wang Meizhen, woman, 58 years old, prescription on individual diagnosis on October 9 calendar year 2001.Cervical spondylosis more than 20 year, often outbreak are suffered from readme.Headache, dizzy, upper limb numbness, unable.Take capsule preparations of the present invention, one day three times, one time five, 15 just obtain produce effects, serve on 3 months clinical Signs and disappear substantially, follow up a case by regular visits to not See recurrence in a year.

The specific embodiment:

In concrete the enforcement, pharmaceutical formulation by weight is: Ganoderma 6～25, Folium Ginkgo 6～30, Herba Epimedii 6～15, Radix Puerariae 6～30, Rhizoma Chuanxiong 6～30, Radix Salviae Miltiorrhizae 6～30, Fructus Crataegi 6～30, Pheretima 5～15.

Its better formula such as table 1 by weight is listed:

Table 1:

	Ganoderma	Folium Ginkgo	Herba Epimedii	Radix Puerariae	Rhizoma Chuanxiong	Radix Salviae Miltiorrhizae	Fructus Crataegi	Pheretima
									1	6.0	6.0	6.0	9.0	6.0	9.0	6.0	5.0
2	18.6	18.6	13.6	18.6	18.6	18.6	18.6	13.6
									3	25.0	30.0	15.0	30.0	30.0	30.0	30.0	15.0

Its optimization formula by weight is: Ganoderma 11.5, Folium Ginkgo 11.5, Herba Epimedii 11.5, Radix Puerariae 17.5, Rhizoma Chuanxiong 11.5, Radix Salviae Miltiorrhizae 17.5, Fructus Crataegi 11.5, Pheretima 11.5.Preparation method such as following embodiment 1 to embodiment 6 at this prescription:

Embodiment 1, the preparation of capsule:

Step 1, get Pheretima, concoct according to stir-baking with vinegar (appendix II D) by pharmacopeia of version in 2000.Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; Get 50% Ganoderma powder and be broken into 10 order Ganoderma coarse powder, Ganoderma coarse powder and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi and Pheretima add 5 times in water by weight and decoct three times, and collecting decoction filters, and are concentrated into relative density under 80 ℃ and are 1.15 extractum;

Step 2, remaining 50% Ganoderma powder are broken into 120 order Ganoderma fine powders;

Step 3, will merge by each extractum of above-mentioned steps 1 gained and by step 2 gained Ganoderma fine powder, add the 2g lactose after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

Step 4: divide the capsule of packing into the dry extract pulverizing, the sterilization back that make, make 100, promptly.

Embodiment 2, the preparation of tablet:

Step 1,2 is with embodiment 1.

Step 3: will merge by each extractum of above-mentioned steps 1 gained and by step 2 gained Ganoderma fine powder, drying under reduced pressure makes dry extract and is the pharmaceutically active composition.

Step 4: the dry extract that makes is pulverized, and drying under reduced pressure is pressed into 100, sugar coating or film-coat, promptly.

Embodiment 3, the preparation of pill:

Step 1,2 is with embodiment 1, and step 3 is as follows:

Step 3: the gained dry extract is pulverized mixing.Use refined honey in per 100 gram powder

Gram adds an amount of water pill, and drying is made water-honeyed pill.Or add refined honey

Restrain into big honeyed pills.

Embodiment 4, the preparation of granule

Step 1,2 is with embodiment 1, and step 3 is as follows:

Step 3: will merge by each extractum of above-mentioned steps 1 gained and by step 2 gained Ganoderma fine powder, every 1g dry extract adds 4.5g sucrose and 1g dextrin, and mixing is ground into fine powder behind the drying under reduced pressure, make granule, drying, promptly.

Step 4 also can be: will merge by each extractum of above-mentioned steps 1 gained and by step 2 gained Ganoderma fine powder, spray drying is got dried cream powder, and every 1g dry extract adds 1g dextrin and an amount of stevioside, mixing, vacuum drying is ground into fine powder, make the sugar-free granule, drying, promptly.

Embodiment 5, the preparation of syrup or extractum

Get Pheretima, concoct according to stir-baking with vinegar (appendix II D) by pharmacopeia of version in 2000.Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; Ganoderma and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi and Pheretima add 5 times in water by weight and decoct three times, and collecting decoction filters, and are concentrated into relative density under 80 ℃ and are 1.15 extractum, put coldly, it is an amount of to add ethanol, leaves standstill, draw supernatant, surplus liquid filters, and filtrate and supernatant merge, and adds 180g sucrose, boil, leave standstill, filter, filtrate concentrates.Add Polysorbate, benzoic acid and receive etc. in right amount, be with the citron acid for adjusting pH value

Stir evenly, filter, leave standstill, fill, sterilization promptly gets syrup or extractum.

Embodiment 6, the preparation of injection:

Get Pheretima, concoct according to stir-baking with vinegar (appendix II D) by pharmacopeia of version in 2000.Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; Ganoderma and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi and Pheretima add 5 times in water by weight and decoct three times, and collecting decoction filters, and are concentrated into relative density under 80 ℃ and are 1.15 extractum, put cold, it is an amount of to add ethanol, leaves standstill, and draws supernatant, surplus liquid filters, filtrate and supernatant merge, and handle twice with ethanol precipitation, and containing the alcohol amount in the solution for the first time is 70%, be 85% for the second time, at every turn all in

Cold preservation is placed after 24 hours and is filtered, and filtrate is concentrated into 20mml, adds the injection water to 80mml, and prediction content is regulated pH value, filters, and adds the injection water to 100mml, embedding, and sterilization, promptly.

In addition, the preferable prescription of medicine of the present invention crude drug by weight comprises that also table 2 is listed:

Table 2:

	Ganoderma	Folium Ginkgo	Herba Epimedii	Radix Puerariae	Rhizoma Chuanxiong	Radix Salviae Miltiorrhizae	Fructus Crataegi	Pheretima	Hirudo	Flos Carthami	Radix Notoginseng
												1	6.0	6.0	6.0	9.0	6.0	9.0	6.0	5.0	6.0	3.0	3.0
2	18.6	18.6	13.6	18.6	18.6	18.6	18.6	13.6	13.6	9.0	13.6
												3	25.0	30.0	15.0	30.0	30.0	30.0	30.0	15.0	15	15	15

Its optimization formula by weight is: Ganoderma, Folium Ginkgo, Herba Epimedii, Rhizoma Chuanxiong, Fructus Crataegi 11.5, Pheretima 11.5 and Hirudo each 11.5, Flos Carthami and Radix Notoginseng each 6.0, Radix Puerariae and Radix Salviae Miltiorrhizae each 17.5.Concrete preparation process at this prescription is:

A, to take by weighing each crude drug by compatibility standby:

B, get Pheretima, stir-baking with vinegar is concocted; Getting 50% Ganoderma powder is broken into 120 orders and gets the Ganoderma fine powder; Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; The Ganoderma powder of remaining part is broken into 10 orders and gets the Ganoderma coarse powder: Flos Carthami adds 1.7 times of boiling water more than 95 ℃ and overflows bubble and filtered in 1 hour, adds 1.5 times of boiling water more than 95 ℃ for the second time and overflows bubble and filtered in 1 hour, merge Flos Carthami filtrate, separate red flower pesticide slag; These Flos Carthami medicinal residues and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, crataegus pin natifida var. Major, Pheretima, Hirudo, Radix Notoginseng and Ganoderma coarse powder add 5 times in water amount by weight and decoct three times, and collecting decoction and medicine flower filtrate filter, and are concentrated into relative density under 80 ℃ and are 1.15 extractum;

C, will merge by each extractum of above-mentioned steps b gained and Ganoderma fine powder, add conventional adjuvant after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

The preferable prescription of medicine of the present invention crude drug by weight comprises that also table 3 is listed:

Table 3:

	Ganoderma	Folium Ginkgo	Herba Epimedii	Radix Puerariae	Rhizoma Chuanxiong	Radix Salviae Miltiorrhizae	Fructus Crataegi	Pheretima	Hirudo	Flos Carthami	Radix Notoginseng	Borneolum Syntheticum
													1	6.0	6.0	6.0	9.0	6.0	9.0	6.0	5.0	6.0	3.0	3.0	0.1
2	18.6	18.6	13.6	18.6	18.6	18.6	18.6	13.6	13.6	9.0	13.6	3.0
													3	25.0	30.0	15.0	30.0	30.0	30.0	30.0	15.0	15	15	15	5.0

Its optimization formula by weight is: Ganoderma, Folium Ginkgo, Herba Epimedii, Rhizoma Chuanxiong, Fructus Crataegi, Pheretima and Hirudo each 11.5, Flos Carthami and Radix Notoginseng each 6.0, Radix Puerariae and Radix Salviae Miltiorrhizae each 17.5, Borneolum Syntheticum 2.0.Concrete preparation process at this prescription is:

A, to take by weighing each crude drug by compatibility standby;

B, get Pheretima, stir-baking with vinegar is concocted; Getting 15% Ganoderma powder is broken into 120 orders and gets the Ganoderma fine powder; Get Borneolum Syntheticum powder and be broken into 150 order Borneolum Syntheticum fine powders; Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; The remaining part Ganoderma powder is broken into 10 orders and gets Ganoderma coarse powder, Flos Carthami and add 1.7 times of boiling water more than 95 ℃ and overflow bubble and filtered in 1 hour, adds 1.5 times of boiling water more than 95 ℃ for the second time and overflows bubble and filtered in 1 hour, merges Flos Carthami filtrate, separate red flower pesticide slag; These Flos Carthami medicinal residues and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, Pheretima, Hirudo, Radix Notoginseng and Ganoderma coarse powder add 5 times in water amount by weight and decoct three times, and collecting decoction and Flos Carthami filtrate filter, and are concentrated into relative density under 80 ℃ and are 1.15 extractum;

C, will merge by each extractum of above-mentioned steps b gained and Ganoderma, Borneolum Syntheticum fine powder, add conventional adjuvant after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

Claims (10)

1, a kind of medicine that is used for the treatment of diseases of cardiovascular and cerebrovascular systems and blood supply insufficiency is characterized in that crude drug by weight consists of: Ganoderma 6～25, Folium Ginkgo 6～30, Herba Epimedii 6～15, Radix Puerariae 6～30, Rhizoma Chuanxiong 6～30, Radix Salviae Miltiorrhizae 6～30, Fructus Crataegi 6～30, Pheretima 5～15.

2, medicine according to claim 1 is characterized in that the prescription of described raw material medicaments in part by weight is: Ganoderma, Folium Ginkgo, Herba Epimedii, Rhizoma Chuanxiong, Fructus Crataegi and Pheretima each 11.5, Radix Puerariae and Radix Salviae Miltiorrhizae each 17.5.

3, the preparation method of a kind of claim 1 or 2 described medicines is characterized in that operating as follows:

A, to take by weighing each crude drug by compatibility standby;

B, get Pheretima, stir-baking with vinegar is concocted; Getting the 30-80% Ganoderma powder is broken into 120 orders and gets the Ganoderma fine powder; Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; Remaining Ganoderma powder is broken into 10 orders and gets the Ganoderma coarse powder, and Ganoderma coarse powder and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi and Pheretima add water 3-8 by weight doubly measures and decoct three times, and the collecting decoction filtration is concentrated into relative density under 80 ℃ and is 1.15 extractum;

C, will merge by each extractum of above-mentioned steps b gained and Ganoderma fine powder, add conventional adjuvant after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

4, medicine according to claim 1 is characterized in that having in addition by weight in the described crude drug: Hirudo 6～25, Flos Carthami 3～15, Radix Notoginseng 3～15.

5, medicine according to claim 4 is characterized in that described medicine prescription by weight is: Ganoderma, Folium Ginkgo, Herba Epimedii, Rhizoma Chuanxiong, Fructus Crataegi, Pheretima and Hirudo each 11.5, Flos Carthami and Radix Notoginseng each 6.0, Radix Puerariae and Radix Salviae Miltiorrhizae each 17.5.

6, the preparation method of the described medicine of a kind of claim 4 is characterized in that operating as follows:

A, to take by weighing each crude drug by compatibility standby;

B, get Pheretima, stir-baking with vinegar is concocted; Getting the 30-80% Ganoderma powder is broken into 120 orders and gets the Ganoderma fine powder; Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; The Ganoderma powder of remaining part is broken into 10 orders and gets the Ganoderma coarse powder; Flos Carthami adds 1.7 times of boiling water more than 95 ℃ and overflows bubble and filtered in 1 hour, adds 1.5 times of boiling water more than 95 ℃ for the second time and overflows bubble and filtered in 1 hour, merge Flos Carthami filtrate, separate red flower pesticide slag; Flos Carthami medicinal residues and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, Pheretima, Hirudo, Radix Notoginseng and Ganoderma coarse powder add water 3-8 by weight doubly to be measured and decocts three times, and collecting decoction and Flos Carthami filtrate filter, and is concentrated into relative density under 80 ℃ and is 1.15 extractum;

C, will merge by each extractum of above-mentioned steps b gained and Ganoderma fine powder, add conventional adjuvant after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

7, medicine according to claim 4 is characterized in that Borneolum Syntheticum 0.1～5 is arranged in the described crude drug by weight in addition.

8, medicine according to claim 7 is characterized in that the prescription of described raw material medicaments in part by weight is: Ganoderma, Folium Ginkgo, Herba Epimedii, Rhizoma Chuanxiong, Fructus Crataegi, Pheretima and Hirudo each 11.5, Flos Carthami and Radix Notoginseng each 6.0, Radix Puerariae and Radix Salviae Miltiorrhizae each 17.5, Borneolum Syntheticum 2.0.

9, the preparation method of the described medicine of a kind of claim 7 is characterized in that operating as follows:

A, to take by weighing each crude drug by compatibility standby;

B, get Pheretima, stir-baking with vinegar is concocted; Getting the 5-40% Ganoderma powder is broken into 120 orders and gets the Ganoderma fine powder; Get Borneolum Syntheticum powder and be broken into 150 order Borneolum Syntheticum fine powders; Herba Epimedii, Folium Ginkgo, Radix Puerariae with 50～90% alcohol reflux three times, are filtered, reclaim ethanol, be concentrated into relative density under 80 ℃ and be 1.25 extractum; The remaining part Ganoderma powder is broken into 10 orders and gets Ganoderma coarse powder, Flos Carthami and add 1.7 times of boiling water more than 95 ℃ and overflow bubble and filtered in 1 hour, add for the second time the casual bubble of 1.5 times of boiling water more than 95 ℃ filtered in 1 hour, merge Flos Carthami filtrate, separate red flower pesticide slag, Flos Carthami medicinal residues and Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, Pheretima, Hirudo, Radix Notoginseng and Ganoderma coarse powder add water 3-8 by weight and doubly measure decoction three times, collecting decoction and Flos Carthami filtrate filter, and are concentrated into relative density under 80 ℃ and are 1.15 extractum;

C, will merge by each extractum of above-mentioned steps b gained and Ganoderma, Borneolum Syntheticum fine powder, add conventional adjuvant after, drying under reduced pressure makes dry extract and is pharmaceutically active and forms.

10,, it is characterized in that the preparation of described medicine comprises peroral dosage form and injection type according to claim 1 or 4 or 7 described medicines.