CN1285354C - Medicine for treating cerebral infarction - Google Patents
Medicine for treating cerebral infarction Download PDFInfo
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- CN1285354C CN1285354C CN 03150283 CN03150283A CN1285354C CN 1285354 C CN1285354 C CN 1285354C CN 03150283 CN03150283 CN 03150283 CN 03150283 A CN03150283 A CN 03150283A CN 1285354 C CN1285354 C CN 1285354C
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- 206010008118 cerebral infarction Diseases 0.000 title 1
- 208000026106 cerebrovascular disease Diseases 0.000 title 1
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Abstract
The present invention relates to medicine for treating cerebral infarction, which is called 'Tongshuannaoling oral administration liquor 'and 'Tongshuannaoling capsules '. The medicine is prepared from astragalus root, blackfungus, red sage root, hemlock parsley, red peony root, tangkuei tail, earthworm, peach seed, safflower and cassia bark, and is a general medicine dosage form; the medicine has favorable the preventing and therapeutical effect on cerebrovascular diseases, and especially has the favorable prevent and therapeutical effect on cerebral infarction. Compared with congener traditional Chinese medicine, the medicine of the present invention not only can take a temporary solution, but also effect a permanent cure, and can reach the purpose of treating both manifestation and root cause of disease. By the clinical observation, during the acute attack period of the cerebral infarction, the dosage form of the oral medicinal liquor is the best; by using impact therapeusis, the present invention has the advantages of convenient taking and obvious effect; compared with chemicals, the present invention has the advantages of large therapeutic effect and small toxic side effect. The present invention is used for the precaution of the cerebral infarction, and the clinical significance is larger; people take the capsules according to requirements, the probability of generating the cerebral infarction is greatly reduced.
Description
Technical field: the present invention relates to the medicine of a kind of treatment and prevention of brain infraction, a kind of specifically Chinese patent medicine that is developed by Chinese medicine belongs to the field of Chinese medicines.
Background technology: cerebral infarction belongs to Chinese medicine apoplexy category, it is one of frequently-occurring disease clinically, pilosity is born in the middle-aged and elderly people more than 40 years old, and the trend of oriented younger development, its pathogenesis is cerebrovascular thrombosis or stops up cerebrovascular by the son of fastening at other position, clinical manifestation mostly is serious cerebral ischemia phenomenon such as happen suddenly in the static state hemiplegia, facial hemiparalysis, aphasis etc., and this sick morbidity is anxious, development is fast, disability rate is high.To the treatment of cerebral infarction, the measures of suiting the medicine to the illness such as low intracranial pressure fall in the general employing of doctor trained in Western medicine at present, and the traditional Chinese medical science generally adopts blood circulation promoting and blood stasis dispelling, ways such as dredging the meridian, and therapeutic effect is all not obvious.Particularly should therefore invent the medicine of a kind of effective treatment and prevention of brain infraction to put prevention first for the treatment of this disease, be pressing for of current medical circle.
Summary of the invention: the objective of the invention is to overcome above-mentioned the deficiencies in the prior art, provide a kind of instant effect, evident in efficacy, the poison effect of paying is little, the medicine of the cerebral infarction for the treatment of both the principal and the secondary aspects of a disease at the same time.
" blood stagnancy due to deficiency of QI " clearly proposed because of " qi as the commander of blood, the capable then blood of gas is capable, the stagnation of QI is blood stasis then " in the cause of disease errors in Medicine Corrected of cerebral infarction.Modern medicine study also proves the main cause that causes cerebral infarction, be owing to atherosclerosis, blood fat height, hyperlipidemia cause the blood vessel infraction, cause cerebral infarction district hypoxic-ischemic, cause the health hemiplegia, just " Ling Shu Miraculous Pivot or Divine Axis calentura " said " hemiplegia "." hemiplegia ... its deficiency of benefit, eliminating to treat the excess syndrome, and can answer also ".So in treatment, with the method for setting upright QI invigorating " its deficiency of benefit ", with the method " eliminating to treat the excess syndrome " of activating blood circulation to dissipate blood stasis.Promote blood capable so select the Radix Astragali, Cortex Cinnamomi, Radix Salviae Miltiorrhizae warming the meridian QI invigorating for use, and each medicine all have potentiation among the other side, because the Radix Astragali has the effect of heart tonifying diuresis and stimulating central nervous system, can make peripheral vasodilation, blood flow increasing; Radix Salviae Miltiorrhizae has activating blood circulation to dissipate blood stasis, the little blood vessel of diastole tip, microcirculation improvement effect; Cortex Cinnamomi has promoting the flow of QI in the collateral by warming the meridian, alleviates cerebral vasospasm, the blood circulation promoting effect; Rhizoma Chuanxiong has promoting flow of QI and blood, the up brain of priming, and expansion of cerebral vascular reduces the intracranial pressure effect; Auricularia have blood vessel " street cleaner's " title, but both blood fat reducing, anticoagulant can soften the embolus in the cerebral infarction again, can also the intestine moistening toxin expelling, and the effect of protection cerebrovascular; Radix Angelicae Sinensis, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami, Pheretima all have the effect of activating blood circulation to dissipate blood stasis collateral dredging.
Said medicine is share, and can improve cerebral circulation effectively, anticoagulant, thrombus, anticoagulant, improves the regressive effect that hemorheology is learned index, blood fat reducing and atheromatous plaque had highly significant.So when being used for acute cerebral infarction clinically, existing eliminating thrombus and removing obstruction in channels effect has the cerebral edema of alleviating effect again, cerebral ischemia has certain therapeutical effect to acute and chronic.
The object of the present invention is achieved like this:
Described pharmaceutical composition of the present invention is composed as follows:
Radix Astragali 100-150 gram
Auricularia 20-25 gram
Radix Salviae Miltiorrhizae 5-12. gram
Rhizoma Chuanxiong 5-12. gram
Radix Paeoniae Rubra 4-8 gram
Radix Angelicae Sinensis 4-8 gram
Pheretima 3-8 gram
Semen Persicae 3-8 gram
Flos Carthami 3-8 gram
Cortex Cinnamomi 3-8 gram
The preferable amount proportioning of pharmaceutical composition of the present invention is:
Radix Astragali 100-150 gram
Auricularia 20-25 gram
Radix Salviae Miltiorrhizae 7-12 gram
Rhizoma Chuanxiong 7-12 gram
Radix Paeoniae Rubra 5-9 gram
Radix Angelicae Sinensis 5-9 gram
Pheretima 4-6 gram
Semen Persicae 4-6 gram
Flos Carthami 4-6 gram
Cortex Cinnamomi 4-6 gram
The optimum amount proportioning of pharmaceutical composition of the present invention is:
The Radix Astragali 150 grams
Auricularia 25 grams
Radix Salviae Miltiorrhizae 12 grams
Rhizoma Chuanxiong 12 grams
Radix Paeoniae Rubra 8 grams
Pheretima 8 grams
Radix Angelicae Sinensis 8 grams
Semen Persicae 6 grams
Flos Carthami 6 grams
Cortex Cinnamomi 6 grams
The said pharmaceutical composition of the present invention can be prepared into any pharmaceutical preparation that is suitable for using clinically according to the process of Chinese medicine preparation of routine; for example tablet, powder, capsule, pill, oral liquid etc.; as long as used pharmaceutical composition of the present invention; no matter take which kind of dosage form, all belong within protection scope of the present invention.
Preferred dosage form of the present invention is oral liquid and capsule.
The preparation method of oral liquid of the present invention (the logical brain Ling oral liquid of fastening) is:
Choose raw material according to above-mentioned each amounts of components, (except the Auricularia) adds 1000 ml waters and soaked 1 hour, after decocting 1 hour taking liquid then (behind the Cortex Cinnamomi down), to add 1000 milliliters in water in the medicinal residues again, decocted again 30-50 minute, take out medicinal liquid with the first time medicinal liquid mix, staticly settle after the filtration, refilter, heat concentrated 300 milliliters, three bags of (bottles) sealings of packing, promptly.
The preparation method of capsule of the present invention (logical bolt brain curing capsule) is:
1, the raw material of choosing according to above-mentioned each amounts of components is gone into oven drying after the mixing.
2, medicine material is pulverized, then with 100 mesh sieves with the medicated powder mixing of sieving.
3, reuse 60 mesh sieves make for twice it reach mix homogeneously.
4, powder is packed into be capsule, every 0.4 gram.
Drug use method of the present invention is:
1, treatment: Cerebral Infarction Patients, from onset of illness, take logical bolt brain Ling oral liquid every day three times, each 100 milliliters, can be continuously with 15 days.Take the edible simultaneously Auricularia of oral liquid.The eating method of Auricularia, with Auricularia clean soak after, add that condiment is eaten raw or fry to eat all can.
2, rehabilitation: the Cerebral Infarction Patients convalescence, every day can oral logical bolt brain curing capsule 12, divides and takes for three times, can take medicine continuously 3 months.
3, prevention: all easy carbuncle in the occipital region infraction persons, every day, oral logical bolt brain curing capsule was 9, and divide and take for 3 times, but continuous use 1 month, drug withdrawal 7 days continued to take medicine 1 month again.
Medicine of the present invention is compared with similar Chinese medicine and is had the following advantages;
1, medicine of the present invention, clinical when being used to control cerebral infarction, existing thrombolytic is opened the logical again effect of plug, and can solve logical associated with hydrocephalus and free radical again increases problem again, so effectively protected cerebral tissue.Clinical proof, not only transference cure is rapid, and reduced significantly that this disease causes disable fatality rate.
2, medicine of the present invention is compared with similar Chinese medicine, and this medicine can not only take stopgap measures, and can also effect a permanent cure, and reaches the purpose for the treatment of both the principal and the secondary aspects of a disease at the same time.Through clinical observation, the cerebral infarction acute attack stage for well, adopts flooding, not only taking convenience, and instant effect with oral liquid formulation.
3, compare with chemical drugs, not only curative effect is big, and toxic and side effects is little.
4, be used for prevention, its clinical meaning is bigger, as long as take capsular people on request, the probability that cerebral infarction takes place can reduce greatly.
5, add Auricularia, have the effect of deposit, vessel softening in tangible blood fat reducing, the removing blood vessel.
For showing the therapeutic effect of the present invention to cerebral infarction, 168 routine brain jam patients are divided into two groups contrast treatment, two groups of patient ages, sex and diseases all adopt random sampling pattern by stages, wherein 120 examples are organized in treatment, matched group 48 examples, curative effect determinate standard is calmed down (method of specifically calming down is simple) according to the apoplexy efficacy assessment standard that passes through for the tcm emergency seminar of the Chinese Medical Association whole nation.
The treatment group adopts logical bolt brain Ling oral liquid or logical bolt brain curing capsule, and matched group adopts XUESAITONG ZHUSHEYE gram dead point every days 1.0, and clinical experiment shows effective percentage apparently higher than matched group, and P value＜0.05 proves notable difference.(seeing table 1 for details)
Table 1 treatment group and the comparison of matched group curative effect (X ± S)
| The example number | Produce effects | Effectively | Invalid | Total effective rate | The P value | |||||
| N | N | ％ | N | ％ | N | ％ | N | ％ | ||
| The treatment group | 120 | 87 | 72.5 | 24 | 20 | 9 | 7.2 | 111 | 92.5 | ＜0.05 |
| Matched group | 40 | 18 | 37.5 | 20 | 41.7 | 10 | 20.8 | 38 | 79.2 | |
In 120 example treatment cases, wherein male 68 examples, women 42 examples, all logical bolt brain Ling oral liquid (capsule) treatments of employing, clinical experiment shows that effective percentage all reaches more than 90% P value＞0.05, no significant difference.(seeing table 2 for details)
The logical bolt brain Ling oral liquid (capsule) of table 2 to men and women's sufferer therapeutic effect relatively
| The example number | Produce effects | Effectively | Invalid | Total effective rate | The P value | |||||
| N | N | ％ | N | ％ | N | ％ | N | ％ | ||
| The women | 42 | 31 | 73.8 | 8 | 19 | 3 | 7.2 | 39 | 92.8 | ＞0.05 |
| The male | 68 | 48 | 72.1 | 14 | 20.5 | 6 | 8.8 | 62 | 92.6 | |
In 120 example treatment cases, the age distribution situation is that maximum 78 years old, minimum 29 years old, clinical experiment showed that logical bolt brain Ling oral liquid (capsule) is all effective to each age group patient.Simultaneously we observe comparison to the convalescent's of treatment group and matched group therapeutic effect, and the result shows, and are little in acute stages treated group and matched group difference, and in convalescent care group curative effect apparently higher than matched group, P value＜0.05, notable difference is arranged.(seeing table 3 for details)
| Acute stage | The example number | Effective percentage | The P value | Convalescent period | The example number | Effective percentage | The P value | ||
| N | N | ％ | N | N | ％ | ||||
| The treatment group | 33 | 29 | 87.8 | ＞0.05 | The treatment group | 78 | 74 | 94.8 | ＜0.05 |
| Matched group | 12 | 10 | 83.3 | Matched group | 26 | 16 | 61.5 | ||
The specific embodiment:
Embodiment 1
Take by weighing raw material by following weight proportion:
The Radix Astragali 120 grams
Auricularia 20 grams
Radix Salviae Miltiorrhizae 8 grams
Rhizoma Chuanxiong 8 grams
Radix Paeoniae Rubra 6 grams
Radix Angelicae Sinensis 6 grams
Pheretima 6 grams
Semen Persicae 5 grams
Flos Carthami 5 grams
Cortex Cinnamomi 4 grams
Add 1000 milliliters in water, soaked 1 hour, decoct 1 hour (under behind the Cortex Cinnamomi) then.After taking out medicinal liquid, add 1500 milliliters in water again, decoct again about 30 minutes, take out medicinal liquid and medicinal liquid hybrid filtering for the first time after, staticly settle and refilter heating and be concentrated into 300 milliliters, divides three bags (bottle) to seal, take one bag (bottle) at every turn.Auricularia is soaked, divide before taking medicine, to eat for three times.
Embodiment 2
Take by weighing raw material by following weight proportion:
The Radix Astragali 120 grams
Auricularia 20 grams
Radix Salviae Miltiorrhizae 10 grams
Rhizoma Chuanxiong 10 grams
Radix Paeoniae Rubra 8 grams
Radix Angelicae Sinensis 8 grams
Pheretima 8 grams
Semen Persicae 6 grams
Flos Carthami 4 grams
Cortex Cinnamomi 5 grams
After the selected oven dry, medicine material is pulverized, then with 100 mesh sieves with the medicated powder mixing of sieving, reuse 60 mesh sieves make for twice it reach mix homogeneously, powder are incapsulated every heavy 0.4 gram.Be used for the prevention of brain infraction, obey each 3 every day three times.Be used for the rehabilitation cerebral thrombosis, obey every day three times, each 4.
Embodiment 3
Take by weighing raw material by following weight proportion:
The Radix Astragali 150 grams
Auricularia 25 grams
Radix Salviae Miltiorrhizae 12 grams
Rhizoma Chuanxiong 12 grams
Radix Paeoniae Rubra 6 grams
Radix Angelicae Sinensis 6 grams
Pheretima 6 grams
Semen Persicae 4 grams
Flos Carthami 4 grams
Cortex Cinnamomi 4 grams
Add 1000 milliliters in water, soaked 1 hour, the back decocts 1 hour (under behind the Cortex Cinnamomi).After taking out medicinal liquid, add 1000 milliliters in water again, decoct again about 30 minutes, take out medicinal liquid and medicinal liquid hybrid filtering for the first time after, staticly settle and refilter heating and be concentrated into 300 milliliters, divides three bags (bottle) to seal, take one bag (bottle) at every turn.Auricularia is soaked, divide before taking medicine, to eat for three times.
Choose raw material according to above-mentioned weight proportion, after the selected oven dry, be ground into 100 purpose fine powders, reuse 60 mesh sieves make for twice it reach mix homogeneously, powder are incapsulated every heavy 0.4 gram.Be used for the prevention of brain infraction, obey each 3 every day three times.Be used for the rehabilitation cerebral thrombosis, obey every day three times, each 4.
Claims (4)
1, a kind of medicine for the treatment of cerebral infarction, it is characterized in that: the raw material of making effective ingredient consists of:
Radix Astragali 100-150 gram
Auricularia 20-25 gram
Radix Salviae Miltiorrhizae 5-12 gram
Rhizoma Chuanxiong 5-12 gram
Radix Paeoniae Rubra 4-8 gram
Radix Angelicae Sinensis 4-8 gram
Pheretima 3-8 gram
Semen Persicae 3-8 gram
Flos Carthami 3-8 gram
Cortex Cinnamomi 3-8 gram.
2, a kind of medicine for the treatment of cerebral infarction, it is characterized in that: the raw material of making effective ingredient consists of:
Radix Astragali 100-150 gram
Auricularia 20-25 gram
Radix Salviae Miltiorrhizae 7-12 gram
Rhizoma Chuanxiong 7-12 gram
Radix Paeoniae Rubra 5-9 gram
Radix Angelicae Sinensis 5-9 gram
Pheretima 4-6 gram
Semen Persicae 4-6 gram
Flos Carthami 4-6 gram
Cortex Cinnamomi 4-6 gram.
3, require 1,2 described medicines according to letter of authorization, it is characterized in that: the consumption proportion of described medicine each component is:
The Radix Astragali 150 grams
Auricularia 25 grams
Radix Salviae Miltiorrhizae 12 grams
Rhizoma Chuanxiong 12 grams
Radix Paeoniae Rubra 8 grams
Pheretima 8 grams
Radix Angelicae Sinensis 8 grams
Semen Persicae 6 grams
Flos Carthami 6 grams
Cortex Cinnamomi 6 grams.
4, require 1 described medicine according to letter of authorization, it is characterized in that: the dosage form of this medicine is oral liquid or capsule preparations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03150283 CN1285354C (en) | 2003-07-24 | 2003-07-24 | Medicine for treating cerebral infarction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03150283 CN1285354C (en) | 2003-07-24 | 2003-07-24 | Medicine for treating cerebral infarction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1569095A CN1569095A (en) | 2005-01-26 |
| CN1285354C true CN1285354C (en) | 2006-11-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03150283 Expired - Fee Related CN1285354C (en) | 2003-07-24 | 2003-07-24 | Medicine for treating cerebral infarction |
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| Country | Link |
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| CN (1) | CN1285354C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100371002C (en) * | 2005-04-25 | 2008-02-27 | 云南生物谷灯盏花药业有限公司 | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN1935211B (en) * | 2006-09-19 | 2010-05-26 | 高庆林 | Medicinal composition for treating cerebral ischemia |
| CN101396441B (en) * | 2007-09-26 | 2011-11-30 | 首都医科大学附属北京友谊医院 | Traditional Chinese medicine composition for treating blood stasis syndrome of multi viscera organs incompetence syndrome |
| CN102048852B (en) * | 2010-12-17 | 2012-05-23 | 马耀茹 | Oral medicine for treating cerebral infarction and relieving limb spasm |
| CN105079407A (en) * | 2014-05-08 | 2015-11-25 | 焦志明 | Traditional herbal medicine composition for preventing cerebral infarction |
| CN106138532A (en) * | 2016-08-04 | 2016-11-23 | 马畅 | The inducing resuscitation for the treatment of cerebral infarction is removed obstacles Chinese medicine and preparation method thereof |
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2003
- 2003-07-24 CN CN 03150283 patent/CN1285354C/en not_active Expired - Fee Related
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| C14 | Grant of patent or utility model | ||
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