CN1528338A - Thunder godvine multi-aglycone drop pill and preparing method thereof - Google Patents
Thunder godvine multi-aglycone drop pill and preparing method thereof Download PDFInfo
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- CN1528338A CN1528338A CNA2003101009221A CN200310100922A CN1528338A CN 1528338 A CN1528338 A CN 1528338A CN A2003101009221 A CNA2003101009221 A CN A2003101009221A CN 200310100922 A CN200310100922 A CN 200310100922A CN 1528338 A CN1528338 A CN 1528338A
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- coolant
- glycosides
- polyethylene glycol
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- tripterygium glycosides
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Abstract
The present invention utilizes ultramicropulverization and dripping pill preparation production process to produce thunder god vine polyglycoside dripping pills, and can attain the goal of raising disintegration dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration, and its compliance is good.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically dripping pills of tripterigium wilfordi glycosides and preparation method thereof.
Background technology
Tripterygium glycosides has the detoxifcation of dispeling the wind, dehumidifying detumescence, channels sootheing and network vessel quickening, effects such as antiinflammatory and inhibition cellular immunization and humoral immunization.Be used for the rheumatic fever stasis of blood, the rheumatoid arthritis due to the poison heresy blocks, nephrotic syndrome, Behcet triad, lepra reaction, autoimmune hepatitis etc.
Tripterygium glycosides mildly bitter flavor, puckery, its disintegration of tablet time is long, absorption difference, bioavailability is low, and the supplementary product consumption ratio is big, and child, old people, bed patient and dysphagia patients are taken inconvenience, compliance is poor, has influenced the performance of Tripterygium glycosides therapeutical effect.
The present invention makes the dripping pills of tripterigium wilfordi glycosides agent by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of Glucosidorum Tripterygll Totorum, and the therapeutical effect of Tripterygium glycosides is given full play to.
Summary of the invention
The dripping pills of tripterigium wilfordi glycosides of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, and is easy to carry and use, and onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also have working condition and production equipment is simple, production cost is low, compare the advantage that supplementary product consumption reduces with tablet, demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the Tripterygium glycosides fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available Glucosidorum Tripterygll Totorum disintegration time testing result: 63 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 5 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 4 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 4 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 6 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 12 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 17 minutes
The specific embodiment
One, example 1
Prescription:
Tripterygium glycosides 5g
Polyethylene glycol 6000 15g
Make 1000
Method for making: the Tripterygium glycosides fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Tripterygium glycosides 5g
Macrogol 4000 15g
Make 1000
Method for making: the Tripterygium glycosides fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Tripterygium glycosides 5g
Polyethylene glycol 6000 5g
Macrogol 4000 10g
Make 1000
Method for making: the Tripterygium glycosides fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Tripterygium glycosides 5g
Glyceryl monostearate 15g
Make 1000
Method for making: the Tripterygium glycosides fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Tripterygium glycosides 5g
Polyethylene glycol 6000 10g
Poloxamer 5g
Make 1000
Method for making: the Tripterygium glycosides fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Tripterygium glycosides 5g
Glyceryl monostearate 15g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that Tripterygium glycosides and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (3)
1. dripping pills of tripterigium wilfordi glycosides and preparation method thereof is characterized in that: the Tripterygium glycosides fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
3. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009221A CN1528338A (en) | 2003-10-08 | 2003-10-08 | Thunder godvine multi-aglycone drop pill and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009221A CN1528338A (en) | 2003-10-08 | 2003-10-08 | Thunder godvine multi-aglycone drop pill and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1528338A true CN1528338A (en) | 2004-09-15 |
Family
ID=34304115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101009221A Pending CN1528338A (en) | 2003-10-08 | 2003-10-08 | Thunder godvine multi-aglycone drop pill and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1528338A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115252626A (en) * | 2022-08-17 | 2022-11-01 | 泰州市中医院 | Pharmaceutical composition containing glucocorticoid and application thereof |
-
2003
- 2003-10-08 CN CNA2003101009221A patent/CN1528338A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115252626A (en) * | 2022-08-17 | 2022-11-01 | 泰州市中医院 | Pharmaceutical composition containing glucocorticoid and application thereof |
| CN115252626B (en) * | 2022-08-17 | 2024-04-02 | 泰州市中医院 | Pharmaceutical composition containing glucocorticoid and application thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |