CN1528284A - Herba seu flos rorippae extract drop pill and preparing method thereof - Google Patents
Herba seu flos rorippae extract drop pill and preparing method thereof Download PDFInfo
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- CN1528284A CN1528284A CNA2003101009452A CN200310100945A CN1528284A CN 1528284 A CN1528284 A CN 1528284A CN A2003101009452 A CNA2003101009452 A CN A2003101009452A CN 200310100945 A CN200310100945 A CN 200310100945A CN 1528284 A CN1528284 A CN 1528284A
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- rorifone
- coolant
- drop pill
- pill
- polyethylene glycol
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Abstract
The present invention utilizes ultramicropulverization and dripping pill preparation production process to make rorifone dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not only can be sucked, but also can be swallowed, and its compliance property is good.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, Shuo Shi rorifone drop pill and preparation method thereof particularly.
Background technology
Rorifone has and eliminates the phlegm, and the cough-relieving function is used for chronic bronchitis.
Rorifone odorless or odorless almost, mildly bitter flavor, insoluble in water, its disintegration of tablet time is long, absorption difference, bioavailability is low, and the supplementary product consumption ratio is big, child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, influence the performance of rorifone therapeutical effect.
The present invention is Chenged the rorifone drop pill by using ultramicro communication technique with dropping pill formulation Technology Zhi, thereby the therapeutical effect of the above defective ， Shi rorifone of Ke Fu rorifone sheet is given full play to.
Summary of the invention
By using ultramicro communication technique and dropping pill formulation Technology make De rorifone drop pill not only have disintegrate molten loose fast, steady quality, the pill volume is little, and is easy to carry and use, and onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also have working condition and production equipment is simple, production cost is low, compare the advantage that supplementary product consumption reduces with tablet, demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: 1 weight portion is added in 1～10 weight portion molten matrix through micronizing De rorifone fine powder, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
The chemical name of rorifone among the Ben Faming (Rorifonum) is the 10-Rorifon, and molecular formula is C
11H
21O
2NS, molecular weight are 231.35, and structural formula is
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, Shi Shou rorifone sheet disintegration time testing result: 72 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 5 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 3 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 4 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 9 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 10 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 12 minutes
The specific embodiment
One, example 1
Prescription:
Rorifone 5g
Polyethylene glycol 6000 15g
Make 1000
Method for making: the micronizing of learning from else's experience is crossed 200 mesh sieve De rorifone fine powders and is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Rorifone 5g
Macrogol 4000 15g
Make 1000
Method for making: the micronizing of learning from else's experience is crossed 200 mesh sieve De rorifone fine powders and is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Rorifone 5g
Polyethylene glycol 6000 5g
Macrogol 4000 10g
Make 1000
Method for making: the micronizing of learning from else's experience is crossed 200 mesh sieve De rorifone fine powders and is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Rorifone 5g
Glyceryl monostearate 15g
Make 1000
Method for making: the micronizing of learning from else's experience is crossed 200 mesh sieve De rorifone fine powders and is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Rorifone 5g
Polyethylene glycol 6000 10g
Poloxamer 5g
Make 1000
Method for making: the micronizing of learning from else's experience is crossed 200 and is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix from Shai De rorifone fine powder, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Rorifone 5g
Glyceryl monostearate 15g
Poloxamer 1g
Make 1000
The mixing fine powders that method for making: Qu rorifone and poloxamer are crossed 200 mesh sieves through micronizing is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. rorifone drop pill and preparation method thereof is characterized in that: 1 weight portion is added in 1～10 weight portion molten matrix through micronizing De rorifone fine powder, and abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the chemical name of claim 1 Suo Shu De rorifone Rorifonum is the 10-Rorifon, and molecular formula is C
11H
21O
2NS, molecular weight are 231.35, and structural formula is
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009452A CN1528284A (en) | 2003-10-06 | 2003-10-06 | Herba seu flos rorippae extract drop pill and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009452A CN1528284A (en) | 2003-10-06 | 2003-10-06 | Herba seu flos rorippae extract drop pill and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1528284A true CN1528284A (en) | 2004-09-15 |
Family
ID=34304129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101009452A Pending CN1528284A (en) | 2003-10-06 | 2003-10-06 | Herba seu flos rorippae extract drop pill and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1528284A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140228433A1 (en) * | 2010-12-15 | 2014-08-14 | Olatec Industries Llc | 3-methanesulfonylpropionitrile for treating inflammation and pain |
-
2003
- 2003-10-06 CN CNA2003101009452A patent/CN1528284A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140228433A1 (en) * | 2010-12-15 | 2014-08-14 | Olatec Industries Llc | 3-methanesulfonylpropionitrile for treating inflammation and pain |
| US8975297B2 (en) * | 2010-12-15 | 2015-03-10 | Olatec Industries Llc | 3-methanesulfonylpropionitrile for treating inflammation and pain |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |