CN1528306A - Noscapine drop pill and preparing method thereof - Google Patents
Noscapine drop pill and preparing method thereof Download PDFInfo
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- CN1528306A CN1528306A CNA2003101009077A CN200310100907A CN1528306A CN 1528306 A CN1528306 A CN 1528306A CN A2003101009077 A CNA2003101009077 A CN A2003101009077A CN 200310100907 A CN200310100907 A CN 200310100907A CN 1528306 A CN1528306 A CN 1528306A
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- narcotine
- coolant
- pill
- polyethylene glycol
- drop pill
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention utilizes ultramicropulverization and dripping pill preparation production process to make noscapine dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not only can be sucked, but also can be swallowed, and its compliance property is good.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically narcotine drop pill and preparation method thereof.
Background technology
The narcotine odorless, almost insoluble in water, be cough medicine, be used for dry cough.But its disintegration of tablet time is long, absorption difference, and bioavailability is low, and the supplementary product consumption ratio is big, and child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, has influenced the performance of narcotine therapeutical effect.
The present invention makes the narcotine drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of narcotine sheet, and the therapeutical effect of narcotine is given full play to.
Summary of the invention
The narcotine drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, both can swallow also can buccal, easy to carry and use, onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also has working condition and production equipment is simple, production cost is low, compares the advantage that supplementary product consumption reduces with tablet, has demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the narcotine fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
The chemical name of narcotine among the present invention (Noscapinum) is [S-(R
*, S
*)]-3-(5,6,7,8-tetrahydrochysene-6-methyl-4-methoxyl group-1,3-dioxole [4,5-g]-6,7-dimethoxy-5-isoquinolyl-1 (3H)-isobenzofuranone, molecular formula is C
22H
23NO
7, molecular weight is 413.43, structural formula is
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available narcotine sheet disintegration time testing result: 59 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 4 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 3 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 4 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 7 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 8 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 10 minutes
The specific embodiment
One, example 1
Prescription:
Narcotine 5g
Polyethylene glycol 6000 15g
Make 1000
Method for making: the narcotine fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Narcotine 5g
Macrogol 4000 15g
Make 1000
Method for making: the narcotine fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Narcotine 5g
Polyethylene glycol 6000 5g
Macrogol 4000 10g
Make 1000
Method for making: the narcotine fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Narcotine 5g
Glyceryl monostearate 15g
Make 1000
Method for making: the narcotine fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Narcotine 5g
Polyethylene glycol 6000 10g
Poloxamer 5g
Make 1000
Method for making: the narcotine fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Narcotine 5g
Glyceryl monostearate 15g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that narcotine and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. narcotine drop pill and preparation method thereof is characterized in that: the narcotine fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, and abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the molecular formula of the described narcotine of claim 1 is C
22H
23NO
7, molecular weight is 413.43, structural formula is
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009077A CN1528306A (en) | 2003-10-08 | 2003-10-08 | Noscapine drop pill and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009077A CN1528306A (en) | 2003-10-08 | 2003-10-08 | Noscapine drop pill and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1528306A true CN1528306A (en) | 2004-09-15 |
Family
ID=34304100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101009077A Pending CN1528306A (en) | 2003-10-08 | 2003-10-08 | Noscapine drop pill and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1528306A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194907B (en) * | 2006-12-08 | 2011-08-10 | 天津天士力制药股份有限公司 | Dropping pills containing noscapine and method for preparing the same |
| CN107661335A (en) * | 2017-10-31 | 2018-02-06 | 广州市桐晖药业有限公司 | A kind of coscopin piece and preparation method thereof |
-
2003
- 2003-10-08 CN CNA2003101009077A patent/CN1528306A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194907B (en) * | 2006-12-08 | 2011-08-10 | 天津天士力制药股份有限公司 | Dropping pills containing noscapine and method for preparing the same |
| CN107661335A (en) * | 2017-10-31 | 2018-02-06 | 广州市桐晖药业有限公司 | A kind of coscopin piece and preparation method thereof |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |