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CN1330513A - 低腺苷反义寡核苷酸、组合物、试剂盒及与支气管紧缩、肺炎、过敏及表面活性剂缺失相关的通气途径疾病的治疗方法 - Google Patents

低腺苷反义寡核苷酸、组合物、试剂盒及与支气管紧缩、肺炎、过敏及表面活性剂缺失相关的通气途径疾病的治疗方法 Download PDF

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Publication number
CN1330513A
CN1330513A CN00801046A CN00801046A CN1330513A CN 1330513 A CN1330513 A CN 1330513A CN 00801046 A CN00801046 A CN 00801046A CN 00801046 A CN00801046 A CN 00801046A CN 1330513 A CN1330513 A CN 1330513A
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CN
China
Prior art keywords
oligonucleotide
receptor
composition
adenosine
antisense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00801046A
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English (en)
Chinese (zh)
Inventor
乔纳森·W·尼斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
East Carolina University
Original Assignee
East Carolina University
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Filing date
Publication date
Application filed by East Carolina University filed Critical East Carolina University
Publication of CN1330513A publication Critical patent/CN1330513A/zh
Pending legal-status Critical Current

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/33—Chemical structure of the base

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  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN00801046A 1999-04-06 2000-03-24 低腺苷反义寡核苷酸、组合物、试剂盒及与支气管紧缩、肺炎、过敏及表面活性剂缺失相关的通气途径疾病的治疗方法 Pending CN1330513A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12795899P 1999-04-06 1999-04-06
US60/127,958 1999-04-06

Publications (1)

Publication Number Publication Date
CN1330513A true CN1330513A (zh) 2002-01-09

Family

ID=22432865

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00801046A Pending CN1330513A (zh) 1999-04-06 2000-03-24 低腺苷反义寡核苷酸、组合物、试剂盒及与支气管紧缩、肺炎、过敏及表面活性剂缺失相关的通气途径疾病的治疗方法

Country Status (9)

Country Link
EP (1) EP1168919A4 (pt)
JP (1) JP2003515525A (pt)
CN (1) CN1330513A (pt)
AU (1) AU4031700A (pt)
BR (1) BR0006019A (pt)
CA (1) CA2330022A1 (pt)
HK (1) HK1042017A1 (pt)
IL (1) IL140054A0 (pt)
WO (1) WO2000062736A2 (pt)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107941681A (zh) * 2013-04-19 2018-04-20 艾皮恩蒂斯有限公司 鉴定生物样品中定量细胞组成的方法
CN108175862A (zh) * 2003-12-03 2018-06-19 科达治疗（新西兰）有限公司 靶向连接蛋白的反义化合物及其使用方法
CN112969799A (zh) * 2018-09-26 2021-06-15 奥姆生命科技公司 2′fana修饰的foxp3反义寡核苷酸及其使用方法
CN114591963A (zh) * 2022-05-10 2022-06-07 上海优替济生生物医药有限公司 sgRNA及利用其构建GM-CSF(-)细胞的方法

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US6737040B1 (en) 1998-08-04 2004-05-18 Diadexus, Inc. Method and antibody for imaging breast cancer
WO2000058468A2 (en) * 1999-03-26 2000-10-05 Human Genome Sciences, Inc. 47 human secreted proteins
DE10049549A1 (de) 2000-10-06 2002-05-02 Markus Hecker Modulation der Transkription pro-inflammatorischer Genprodukte
AU2002319033B2 (en) 2001-07-06 2008-01-10 Pharmaxis Ltd Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals
WO2004086052A2 (en) * 2003-03-28 2004-10-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor adenosine a2b (adora2b)
US7671182B2 (en) * 2003-03-31 2010-03-02 Council Of Scientific & Industrial Research Gene variants of signal transducer and activator of transcription-6 (STAT 6) variants and process of detection the same
WO2006010492A1 (en) * 2004-07-28 2006-02-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with tryptase 1 (tps1)
US7485468B2 (en) 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
US8673268B2 (en) 2004-10-15 2014-03-18 Galapagos N.V. Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
WO2006086821A1 (en) * 2004-10-20 2006-08-24 Antisense Therapeutics Ltd ANTISENS MODULATION OF INTEGRIN α4 EXPRESSION
ES2450929T3 (es) 2004-10-29 2014-03-25 Topigen Pharmaceuticals Inc. Oligonucleótidos antisentido para tratar la alergia y la proliferación de las células neoplásicas
AU2005307831A1 (en) 2004-11-17 2006-05-26 Amgen, Inc. Fully human monoclonal antibodies to IL-13
EP1877557A2 (en) 2005-04-04 2008-01-16 The Board of Regents of The University of Texas System Micro-rna's that regulate muscle cells
PL2068889T3 (pl) 2006-08-10 2020-06-29 Roy C. Levitt Anakinra do zastosowania do leczenia zespołu zarostowego zapalenia oskrzelików
WO2010111503A2 (en) * 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF THE HIGH AFFINITY IGE RECEPTOR ALPHA CHAIN (FCεRLα) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
CN109260217A (zh) * 2018-09-30 2019-01-25 深圳松乐生物科技有限公司 3`-脱氧次黄嘌呤核苷在制备用于多种疾病药品、食品或保健品中的应用

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DE637965T1 (de) * 1991-11-26 1995-12-14 Gilead Sciences Inc Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen.
US5858784A (en) * 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5320962A (en) * 1992-07-22 1994-06-14 Duke University DNA encoding the human A1 adenosine receptor
US5801154A (en) * 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US6025339A (en) * 1995-06-07 2000-02-15 East Carolina University Composition, kit and method for treatment of disorders associated with bronchoconstriction and lung inflammation
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CN1317009A (zh) * 1998-08-03 2001-10-10 东卡罗来纳大学 低腺苷反义寡核苷酸制剂、组合物、试剂盒及处理

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108175862A (zh) * 2003-12-03 2018-06-19 科达治疗（新西兰）有限公司 靶向连接蛋白的反义化合物及其使用方法
CN108175862B (zh) * 2003-12-03 2022-02-08 科达治疗（新西兰）有限公司 靶向连接蛋白的反义化合物及其使用方法
CN107941681A (zh) * 2013-04-19 2018-04-20 艾皮恩蒂斯有限公司 鉴定生物样品中定量细胞组成的方法
CN107941681B (zh) * 2013-04-19 2021-07-30 艾皮恩蒂斯有限公司 鉴定生物样品中定量细胞组成的方法
CN112969799A (zh) * 2018-09-26 2021-06-15 奥姆生命科技公司 2′fana修饰的foxp3反义寡核苷酸及其使用方法
CN114591963A (zh) * 2022-05-10 2022-06-07 上海优替济生生物医药有限公司 sgRNA及利用其构建GM-CSF(-)细胞的方法
CN114591963B (zh) * 2022-05-10 2022-07-19 上海优替济生生物医药有限公司 sgRNA及利用其构建GM-CSF(-)细胞的方法

Also Published As

Publication number Publication date
IL140054A0 (en) 2002-02-10
AU4031700A (en) 2000-11-02
WO2000062736A2 (en) 2000-10-26
EP1168919A4 (en) 2002-03-06
BR0006019A (pt) 2001-03-13
WO2000062736A3 (en) 2001-10-11
CA2330022A1 (en) 2000-10-26
EP1168919A2 (en) 2002-01-09
JP2003515525A (ja) 2003-05-07
HK1042017A1 (zh) 2002-08-02

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