JP2003515525A - 気管支収縮、肺炎、アレルギーおよびサーファクタント枯渇と関連する気道障害を治療するための、低アデノシンアンチセンスオリゴヌクレオチド、その組成物、キットならびにその方法 - Google Patents

Abstract

(57)【要約】 標的遺伝子またはmRNAに核酸を選択的に送達するインビボでの方法は、開始コドン領域、コード領域、5’-3’イントロン-エキソン接合部、あるいは遺伝子の接合部の2〜10のヌクレオチドの領域、にアンチセンスである、または遺伝子に相補的なmRNAにアンチセンスである、治療量のオリゴヌクレオチド（オリゴス）を、標的ポリヌクレオチドに到達させて発現を減少または阻害するために有効な量で、患者の、例えば呼吸系へ局所投与することを含む。さらに、治療の方法およびアデノシン仲介効果は、呼吸、肺または気道疾病の治療に有効な量のアンチセンスオリゴスを患者に局所投与することを含む。それらの代謝によるアデノシンレセプターの誘発を最少にするために、投与されるオリゴスは、アデノシンの含有量が低い、または基本的に含まない。医薬組成物および調合物は、アデノシンレセプター、それらをコードする遺伝子およびmRNA、ゲノムおよびmRNAのフランキング領域、イントロンとエキソンの境界、ならびに、ポリペプチドをコードする遺伝子およびmRNAのすべての調節および機能に関連するセグメント、に対するオリゴアンチセンス、それらの塩ならびにその混合物、を含む。さまざまな調合物は、必要とされる担体、および所望であればその他の添加物および生物学的に活性な薬剤を含む。本発明の方法を実施するための低アデノシンまたはアデノシン非含有（des-A）薬剤は、肺気道を冒す疾病または病状と関連する標的遺伝子、ゲノムフランキング領域，RNA、および／またはポリペプチドを選択し、標的遺伝子および／またはゲノムフランキング領域と関連するmRNAおよび／または標的ポリペプチドをコードするRNAの配列を得、チミジン（T）含有量の最大で60％のチミジンを含まない、少なくとも一つのmRNAセグメントを選択し、そして、オリゴヌクレオチド内にアデノシン（A）が存在する場合、Aを天然発生塩基で置換することによりアデノシンを含まないmRNAセグメントに対する1以上のアンチセンスオリゴヌクレオチドを合成することによって、調製される。また、T含有量が低く、GCランニングストレッチ(running stretch) を持つ標的核酸配列を選択することによって、また、所望であればアンチセンスオリゴヌクレオチド内のAを”天然発生または代替塩基”で置き換えることによって、薬剤を調製することもできる。薬剤、組成物および調合物は、呼吸障害、肺アレルギーおよび／または炎症、ならびに肺血管収縮、炎症、アレルギー、アレルギー性、喘息、呼吸困難、肺痛、嚢胞性線維症、気管支収縮のような、肺サーファクタント涸渇、およびサーファクタント生成欠如と関連する病気の予防的、防御的、および治療的治療のために用いられる。本発明は、例えば、その他にもいろいろあるが、照射、化学療法、抗体療法、および外科手術を含む、その他の治療前、治療中および後の、その他の治療と組み合わせての投与に適している。代わりに、本薬剤は、それ自身が既知の治療を行わない状態に、または望ましくない副作用を示す治療の代わりとして、予防的または治療的に有効に投与される。本発明の治療を、直接患者の呼吸系内に投与することができ、そうすることによって、薬剤は、病気の症状を軽減または阻害するために効果的な量で、直接的に肺に、または、例えば、局所、経皮 、移植等の、その他の有効な投与経路によって、接近しうる。

Description

【発明の詳細な説明】

【０００１】 発明の分野 本発明は、アデノシンレセプターに対してアンチセンスであり、少量のアデノ
シン（A）を含むかまたは含まないオリゴヌクレオチド（単数または複数）（オ
リゴ（単数または複数））を含む組成物に関する。これらの薬剤は、その他にも
いろいろあるが、肺病および二次作用で患者の肺に悪影響を及ぼすような疾病を
含む、炎症、気道障害と関連する肺疾患の治療に適している。これらの疾病の例
としては、アレルギー、喘息、呼吸障害、アレルギー性、痛み、嚢胞性線維症お
よび白血病のようなガン、例えば結腸ガン、等が挙げられる。本薬剤は、他の治
療法と合わせて、予防的または治療的に投与することができ、明らかに負の副作
用を持つ治療法の代わりとして利用することができる。

【０００２】 発明の背景 呼吸性疾患は、さまざまな疾病および状態と関連するが、一般の人々に非常に
多くみられ、アフリカ系アメリカ人のようなある民族集団にはより多く認められ
る。ある場合、それら疾病は、炎症を伴い、肺の状態を一層悪化させる。例えば
、喘息は工業地帯内で最も一般的な疾病の一つである。合衆国では、全健康管理
費用の約1％を占めている。過去10年以上にわたって、喘息の有病率と死亡率の
両方の危機的増加が報告されており、喘息は、これから10年間の顕著な独占的肺
疾患になると予想される。工業地帯での喘息の死亡率増加は、この疾病治療で頼
りになるβアゴニストの涸渇に帰因するが、喘息の根本的原因は、未だ殆ど分か
っていない。

【０００３】 アデノシンは、気管支喘息を含むさまざまな疾病に関して、肺内で重要な仲介
物質の構成要素であろう。その潜在的役割は、喘息患者がエアゾール化アデノシ
ンに良く反応して顕著な気管支収縮を呈するが、正常な個体は反応しないと言う
知見から示唆された。喘息のウサギ動物モデル、ヒト喘息の代わりのほこりダニ
アレルギー性ウサギモデルは、エアゾール化アデノシンに同様の様式で反応し、
顕著な気管支収縮を呈するが、喘息でないウサギは反応を示さなかった。この動
物モデルでのごく最近の研究は、アデノシン-誘導気管支収縮および喘息での気
管支過剰反応が、主にアデノシンレセプターの刺激を通して仲介されうることを
、示唆した。また、アデノシンは、過去に過剰反応気道を持つと診断されたこと
のない患者に、他の疾病および病状を治療するために投与した場合、死を含む副
作用の原因となることが分かっている。

【０００４】 呼吸疾患および病状を治療するために入手できる薬剤は僅かであり、しかも、
一般に、それらにはすべて制限がある。テオフィリンは、喘息治療の重要な薬剤
であり、喘息ウサギのアデノシン-仲介気管支収縮をなくすことが報告されてい
る既知のアデノシンレセプターアンタゴニストである。選択的アデノシンA₁レセ
プターアンタゴニスト、8-シクロペンチル-1、3-ジプロピルキサンチン（DPCPX
）もまた、アレルギー性ウサギのアデノシン仲介気管支収縮および気管支過剰反
応を妨げることが報告されている。最近入手できるようになったアデノシンA₁レ
セプター-特異的アンタゴニストの治療的予防的適用は、やはり、それらが毒性
を持つために制限される。テオフィリンは、例えば、喘息の治療に広く用いられ
ているが、治療投与量範囲が狭いことに帰因して、しばしば明らかな毒性を呈す
る。DPCPXは、毒性が強すぎて、臨床的に有用であるとは言い難い。この十年間
広範に研究が行われたにもかかわらず、特異的アデノシンレセプターアンタゴニ
ストが臨床使用に利用できないという事実は、これら薬剤の一般毒性を実証して
いる。アンチセンスオリゴヌクレオチドは、ヒトの疾病に潜在的に有用な医薬品
としてかなり理論的考察を受けた。しかしながら、ヒト疾病の実際モデルにおけ
るそれらの実地適用では、多少不可解なことがあった。それらの効果的適用への
一つの重大な障害は、それらの作用部位へ薬剤を送達する適当な投与経路を見つ
けだすことが難しいことであった。インビボでの数多くの実験は、アンチセンス
オリゴヌクレオチドを脳の特定領域に直接投与することによって、行われた。し
かしながら、これらの適用は、それらの侵略的形態により、必然的に臨床使用が
制限される。アンチセンスオリゴヌクレオチドは、ヒト疾病における医薬品とし
てのそれらの潜在的使用について、かなりの理論的考察を受けたが、しかしなが
ら、ヒト疾病の実際モデルでこれら薬剤についての実質的効果的適用を見出すこ
とは、特にそれらを大量投与しなくてはならないと言う理由のため、長い間極め
て稀であった。これら分子の薬学的適用において考えなくてはならないもう一つ
の重要なことは、それらの投与経路である。インビボでの数多くの適用には、脳
の限定領域へのアンチセンスオリゴヌクレオチドの直接投与が含まれている。し
かしながら、そのような適用は、それらの侵略的形態故に、臨床的利用を制限す
る。医薬品としてのアンチセンスオリゴヌクレオチドの全身投与は、疾病を含む
組織の標的化の元来の難しさが最少のものではなく、さらに明らかな問題を持つ
ことが分かった。即ち、循環系におけるアンチセンスオリゴヌクレオチドの希釈
の必要性は、静脈または経口投与により標的組織が治療投与量を獲得することを
、極端に難しくしている。経口投与されたアンチセンスオリゴヌクレオチドのバ
イオアベイラビリティーは非常に低く、約5％より少ないオーダーである。アン
チセンスオリゴヌクレオチドは、本発明者を含む、彼の以前の仕事で、肺へのこ
れらの薬剤の直接投与によってさまざまな疾病および病状の治療に成功した多く
の人々によって、治療に用いられてきた。数多くの例では、他の研究者らは、所
望標的へのDNA分子の送達に関して困難さに直面しなければならなかった。この
ように、投与経路は、全身的疾病および病状ならびに局所的それらの治療に極め
て重要である。これに対して、現時点まで、アンチセンス薬剤の肺への送達につ
いては、比較的開発されてこなかった。本発明に従って以下により詳細に記載さ
れるように、肺は、アンチセンスオリゴヌクレオチドの直接投与に関して卓越し
た標的であり、侵略的でない組織特異的経路を提供する。

【０００５】 明らかに、現在のところ、これらの病気を治療する有効な治療法は存在しない
、または、有効であって且つ明らかに有害な副作用を妨げる治療法は少なくとも
存在しない。従って、未だ、肺を冒すアデノシン仲介疾病、および、呼吸問題、
気管支収縮、炎症、アレルギー、サーファクタント（surfactant）涸渇（deleti
on）または分泌欠乏（分泌不全）（hyposecretion）等を含む、肺気道（lung ai
rway）に影響を与える呼吸疾病を治療するための、有効性が高く充分に選択的で
あってその他の治療法によって生み出される有害な副作用を防ぐ、薬剤が必要で
ある。さらに、低量の治療薬剤を要求し、mRNAの組織遺伝子の迅速な標的化への
接近および患者を苦しめる都合の悪い逆効果に有効であろう、送達方法を手に入
れることが、明らかに必要である。

【０００６】 発明の要約 一般に、本発明は、アンチセンスオリゴヌクレオチド［オリゴ（単数または複
数）］：気管支収縮および／または肺炎。アレルギー、および／またはサーファ
クタント涸渇および／または分泌不足を緩和するために有効であり、哺乳動物へ
の投与時に、約0〜約15％アデノシン（A）を含み、肺気道機能障害と関連する、
開始コドン、コード領域、5’末端および3’末端ゲノムフランキング領域、5’
および3’イントロン-エキソン接合部（ジャンクション、junction）、ならびに
標的ポリペプチドをコードする遺伝子の接合部の2〜10のヌクレオチドの領域、
からなる基から選択された標的に対してアンチセンスであるか、またはポリペプ
チドmRNAに対してアンチセンスである上記オリゴ：オリゴの組み合わせ：および
オリゴの混合物：ならびに医薬としてまたは家畜の病気の治療に関して許容しう
る担体または希釈剤を含む、医薬的または家畜の病気の治療に関する組成物に関
する。標的は、典型的には、他にもいろいろあるが、転写因子、ペプチド刺激活
性化因子、サイトカイン、サイトカインレセプター、ケモカイン、ケモカインレ
セプター、アデノシンレセプター、ブラディキニンレセプター、内因的に生成さ
れる特異的非特異的酵素、イムノグロブリンおよび抗体、抗体レセプター、中枢
神経系（CNS）(cntral nerbous system)ならびに末梢神経および非神経系レセプ
ター、CNAおよび末梢神経および非神経系ペプチド伝達物質（transmitter）、接
着分子、デフェンシン、成長因子、バソアクティブペプチドおよびレセプター、
結合タンパク質ならびに成熟関連タンパク質のような、気道疾病、ガン等と関連
する分子である。例として、アデノシンレセプター（類）を標的としたオリゴ（
単数または複数）が挙げられ、典型的には、その他にもいろいろあるが、気道閉
塞症、炎症、アレルギー（類）、およびサーファクタント欠乏の様な、アデノシ
ン仲介影響の減少に有効な量で組成物中に存在している。好ましくは、アデノシ
ンレセプターは、アデノシンA₁、A_2bおよびA₃レセプター、ならびに、ある場合
には更にアデノシンA_2aレセプター、からなる群より選択される。本発明のオリ
ゴは、（a）アデノシン-仲介気管支収縮、呼吸障害、炎症、アレルギー、サーフ
ァクタント生成の涸渇、および治療の必要な患者のその他の有害な肺への影響を
減少させるための、および／または（b）喘息、嚢胞性線維症、アレルギー性、C
DPD等のような具体的疾病および病状を治療するための、薬剤の製造に適用され
うる。最初に、本発明は、1つ以上のオリゴヌクレオチドの呼吸系内への直接的
な標的化投与を提供する。オリゴは、任意の標的に向けることができ、望ましい
標的ポリペプチド、例えばmRNAとハイブリダイゼーションさせるために肺の粘膜
組織を通して迅速に送達されるように計画すると、遺伝子の転写および翻訳を妨
げ、そうすることによって、タンパク質発現は減少する、妨げられる、あるいは
完全に停止するであろう。このように、本発明は、また任意の型の疾病と関連す
る標的化遺伝子およびmRNAにアンチセンスであるオリゴヌクレオチドを、呼吸系
内への直接投与によって、例えば吸入によって、呼吸気道内への溶液またはエア
ゾール導入によって、および．または直接肺内へ投与する、より一般的な方法を
提供する。

【０００７】 さらに、本発明のオリゴは、さまざまな標的タンパク質および遺伝子によって
仲介される影響、例えば、肺、呼吸器、およびその他の関連する影響、例えば気
管支収縮、炎症、免疫仲介反応、アレルギー、およびガンを含む異なる状態を原
因とするその他の気道の問題、を含むアデノシン仲介影響、を減少させるために
適当である。本発明の薬剤で防止的、予防的および治療的に治療することのでき
る、疾病および病状の例としては、肺血管収縮、炎症、アレルギー、喘息、呼吸
障害、呼吸窮迫症候群、痛み、嚢胞性線維症、アレルギー性、肺高血圧症、肺血
管収縮、気腫、慢性閉塞性肺疾患（COPD）、気管支炎、ならびに、白血病、リン
パ腫、ガン腫等、例えば結腸ガン、乳ガン、肺ガン、膵臓ガン、肝細胞ガン、腎
臓ガン、黒色腫、肝転移等、ならびに乳ガンおよび前立腺ガンを含む、肺に転移
する可能性のある、または転移した、すべての型のガン、があげられる。また、
本薬剤は、ガンの照射療法、化学療法、抗体療法、光線療法を含むその他の治療
、およびその他の型の外科手術の前、間および後の投与に適している。本薬剤は
、その他の療法と合わせて、または既知の治療を施さず病状に単独で、または有
意な負の副作用を持つ治療の代わりとして、予防的および治療的に有効に投与さ
れる。オリゴ（単数または複数）は、既知の任意の手段で、患者、例えば患者の
肺に、より一般的には任意のおよびすべての全身的および局所的経路を通して、
投与することができる。用いられるこのオリゴヌクレオチド［オリゴ（単数また
は複数）］は、標的DNAまたはRNA、例えばアデノシンレセプターDNAまたはRNA、
に対してアンチセンスであり、好ましくは、実質上、最大で約15％のアデノシン
（A）からなり、より好ましくはアデノシンを含まない。オリゴスは、担体また
は希釈剤を含み、所望であればその他の治療薬剤、ならびに具体的経路、例えば
呼吸系、局所、経皮、非経口、移植等による投与に用いられる付加剤を含む、具
体的組成物および調合物の形で提供される。また、オリゴは、カプセルまたはカ
ートリッジとして、およびキットの形で、提供される。本発明のオリゴスは、以
下に記載のようなアデノシンレセプターをコードする遺伝子またはmRNAの特異的
標的化セグメントの選択によって作り出すことができる。一つの好ましい実施態
様では、選択は、実質上約15％より少ないアデノシン（A）からなるオリゴスを
得るために行われる。このことは、上記のように、肺気道を冒す病気と関連する
、遺伝子、ゲノムフランキング領域、RNAsおよびポリペプチドを含む、標的を選
択し；標的遺伝子および／またはそれらのゲノムフランキング領域および／また
はその膜近傍領域に相当するmRNA（s）、ならびに標的ポリペプチドをコードす
るmRNA（s）の配列を得、そして少なくとも一つのmRNA（s）セグメントを選択し
、選択されたmRNAセグメントに対する1以上のアンチセンスオリゴヌクレオチド
を合成し、そして、必要であれば、1以上のAを、代替物、例えばユニバーサル塩
基（類）（Universal Base）またはその他の塩基（類）で置換して、オリゴヌク
レオチド内に存在するAの割合を、約15％以下に、アデノシンを含まないところ
まで減少させることによって、行うことができる。同様に、代替および／または
一般的塩基を、アデノシンの代わりに用いることができる、例えば、アデノシン
特異的A1、A2bおよびA3レセプターアンタゴニストまたはA2aレセプターアゴニス
ト、テオフィリン、エンプロフィリン、およびこの技術分野で既知の数多くの他
のアデノシンレセプターアンタゴニスト、ならびに、アデノシンに関して有意に
減少したアゴニスト活性、例えば0．5％以下、0．3％以下等、を持つアゴニスト
。

【０００８】 本発明は、今、具体的実施例に関して、一般的に、概念的実験的用語で記載さ
れるであろう。本発明のその他の目的、長所および特徴は、以下の説明から当業
者に明らかになるであろう。

【０００９】 好ましい実施態様の詳細な説明 本発明は、先行技術での肺およびその他の疾病の治療を改良すると言う発明者
の願いから起こり、その技術は、一般に、高投与量の治療薬剤を投与する必要性
による、有害な副作用と戦う。本発明は、アデノシンレセプターを標的とするア
ンチセンスオリゴヌクレオチド（オリゴ、単数または複数）が、呼吸を障害する
、炎症および／またはアレルギーの原因となる、気管支組織を収縮させる、肺気
道を塞ぐ、サーファクタントの分泌を涸渇させる、または一方で正常な呼吸を妨
げる、疾病または状態の治療に用いることができる言う、発明者自身の発見から
起こっている。一般に、多くの疾病および病状は、炎症と関連する、またはこれ
を原因とする、気管支組織または肺気道を収縮させる、サーファクタントの分泌
を涸渇させる、アレルギーを増大させる、または一方で正常な呼吸を妨げる。こ
の治療は、これらの徴候と関連する、または仲介する特異的標的について選択的
であり、薬剤は、この技術分野で認められている投与量の最大で1／1000倍の低
い投与量で投与される。発見者は、さらに、抗体療法、化学療法、照射療法、光
学療法および手術、例えばガン手術を含む、その他の方法を受けている、または
その他の治療を施されている患者の結果およびライフスタイルを改良するであろ
う、そして防御的、予防的または治療的に有効に投与されうるであろう、治療を
提供したいと考えた。発明者は、アデノシン含有量を減らしたオリゴを選択する
、または、そうでなければ内因性ポリヌクレオチド配列に相当する標的化された
アンチセンスオリゴスのアデノシン含有量を減少させることによって、この発見
をさらに改良できると、推論した。本発明は、オリゴヌクレオチドがインビボで
モノヌクレオチドに代謝されることが発明者によって発見されたことを前提とし
ている。アデノシン（A）-含有オリゴヌクレオチドを壊して、順々にアデノシン
レセプターを活性化し、それによって、気管支収縮、炎症、サーファクタント涸
渇、アレルギー等の原因となる、アデノシンを放出させる。このようにして、彼
は、低アデノシン-アデノシンフリーオリゴスを用い、それらの投与時のこれら
の副作用を防ぐことを、考えた。彼はこの努力で成功し、この特許で、気管支収
縮、アレルギー、炎症、呼吸困難、サーファクタント涸渇、および気道ブロック
、ならびに直接または間接的に肺に影響を及ぼすその他の病状を予防し緩和する
以前から知られていた治療法と比較した場合、大きく改良された結果を提供する
、新規の改良された組成物、調合物および方法を提供している。別の実施態様で
は、本発明の1以上の核酸を、単独で、および／または1以上の界面活性剤成分と
共に、および／または担体と共に、および／またはこの技術分野で既知のその他
の治療薬剤および／または調合薬剤と共に、調合することができる。従って、本
発明の組成物は、全身および局所投与用のさまざまな調合物内に取り入れること
ができる。さらに、また、発見者は、喘息の急性発作および急激に発症するその
他の疾病および病状に向けられた治療開始の迅速な手段として、アンチセンスオ
リゴヌクレオチド（オリゴス）を呼吸系を通して送達するための広範な方法を提
供している。さらに、本薬剤は、半減期が長く、非常に低い投与量で投与するこ
とができる。このことにより、本薬剤は週一回型治療に理想的である。過去に、
アンチセンスオリゴヌクレオチドは、ヒト疾病治療用の医薬品として有用である
可能性があるという、考慮に値する理論的考察を受けたことがある（Wagner，R
．，Nature，372，333〜335、1994）。しかしながら、これらの分子をヒト疾病
を緩和し治療するために実際に適用することは、難しかった。これら分子の薬学
的適用における一つの重要な検討事項は、それによって非常に多くの副作用を引
き起こす、循環およびそれによるその他の非標的組織への侵入を防ぎながら、化
合物をその標的に送達するためのさまざまな投与経路が失敗に終わったことであ
る。アンチセンスオリゴヌクレオチドを利用する大部分のインビボでの実験は、
脳の限定領域へのオリゴの直接適用を含んでいる。Wahlestedt，C．，Trends i
n Pharmacol．Sci．，15，42ー45、1994；Lai,J．ら、neuroreport，5，1049-1
052、1994；Standifer，K．ら、Neuron，12，805-810、1994；Akabayashi，A．
ら、Brain Res．，21，55-61、1994、を参照のこと。別の人達はそれらを骨髄液
内に適用した。例えば、Tseng，L．ら、European J．Pharmacol．，258，R1-3
、1994；Raffa，R．ら、European J．Parmacol．，258，R5-7、1994；Gilardon
，F．ら、European J．Neurosci．，6，880-884、1994；を参照のこと。そのよ
うな適用は、明らかに、それらの侵略的性質により、実行可能な臨床的有用性を
持たない。従って、アンチセンスオリゴヌクレオチドの全身投与は、それらの薬
学的適用に関して明らかな問題を持ち、疾病を含む組織を選択的に標的化する難
しさは、大いなる問題である。また、アンチセンスオリゴヌクレオチドの全身投
与は、それらの薬学的適用に関して明らかな問題を持ち、疾病を含む組織を選択
的に標的化する難しさは、大いなる問題である。

【００１０】 しかしながら、生物体内に侵入する最終港としての呼吸系、特に肺は、アンチ
センスオリゴヌクレオチド投与のすぐれた経路である。これは肺疾病の治療のた
めだけでなく、特にその非侵略的組織特異的性質故に、送達の手段として肺を利
用する場合にもすぐれている。このように、標的組織への直接的アンチセンスオ
リゴヌクレオチドの局所送達は、これら化合物の治療での使用を可能にする。Fo
mivirsen（ISIS2302）は、シトメガロウイルス（CMV）網膜炎を治療するための
眼内への局所薬剤送達の例であり、それについての新たな薬剤適用はISISによっ
て提出されている。肺を通しての薬剤投与は、眼の硝子体内への直接注射が侵略
的であるのに対して、吸入は非侵略的であるという、さらなる利益をもたらす。
本発明の組成物および調合物は、その他にもいろいろあるが、気管支収縮、呼吸
困難、妨げられ塞がれた肺気道、アレルギー、炎症およびサーファクタント涸渇
と関連する疾病および病状の予防および治療に非常に良く効く。本方法による治
療に適当な疾病および病状の例としては、急性呼吸窮迫症候群（ARDS）(Acute R
espiratory Distress Syndrome) 、喘息、アデノシン投与を含む疾病および病状
、例えば上部心室性頻脈（SVT）(Supra Ventricular Tachycardia)およびその他
の不整脈の治療、ならびに過敏症個体、虚血、ある薬剤によって誘導された腎臓
損傷または腎不全、新生児呼吸窮迫症候群、痛み、嚢胞性線維症、肺高血圧、肺
血管収縮、気腫、慢性閉塞肺疾患（COPD）(chronic obstructive pulmonary dis
ease) 、肺移植切除、肺感染症、および白血病、リンパ腫、カルシノーマ等の様
な、結腸ガン、乳ガン、肺ガン、膵臓ガン、肝細胞ガン、腎臓ガン、黒色腫、肝
臓転移等、ならびに、乳ガンおよび前立腺ガンを含む、肺に転移する可能性があ
る、または転移したすべての型のガンを含むガンへのストレステスト、が挙げら
れる。本発明は、標的としてのアデノシンレセプターについて記載されるであろ
うが、アンチセンスオリゴスの肺投与に関して任意のその他の標的と同様に適用
できる。以下に提供された例は、ヒト気管支収縮、アレルギーおよび炎症ならび
に卓越しすぎたアデノシンレセプターアゴニストの能力の除去に関するウサギモ
デルでのそのようなアデノシンレセプター関連症候群の完全な阻害を示し、アデ
ノシンはアデノシンレセプターアゴニストに対するヒト過敏症についての動物モ
デルである、過敏症サルでの気管支収縮の原因となる。それ故、本発明の医薬組
成物および調合物は、アデノシンA₁レセプターのようなアデノシンレセプターの
刺激に関する症候群の予防および緩和に適当である。このように、本発明の組成
物および調合物は、また、一般に呼吸活性が冒されている疾病に認められる、あ
る個体内でのアデノシン仲介過敏症の有害な副作用の予防にも適当である。

【００１１】 本発明の方法を用いると、アンチセンス化合物のアデノシン含有量を最少にし
、減少させ、または除去し、そうすることによってアンチセンス崩壊時のその放
出を妨げる目的と共に、任意の種類の患者および任意の理由で気道疾病および病
状を治療することができる。本発明の組成物および調合物で、防止的、予防的、
治療的に治療することのできる、疾病および病状の例としては、肺血管収縮、炎
症、アレルギー、喘息、アレルギー性 、呼吸障害、急性呼吸窮迫症候群（ARDS
）、虚血と関連する腎臓障害および腎不全、ならびに、例えば上部心室性頻脈（
SVT）およびアデノシンストレステストにおける、ある薬剤投与、アデノシン投
与と関連する副作用、新生児呼吸窮迫症候群（infantile RDS）、ARDS、痛み、
嚢胞性線維症、肺高血圧、肺血管収縮、気腫、慢性閉塞性肺疾患（COPD）、肺移
植切除、肺感染症、および白血病、リンパ腫、カルシノーマ等のようなガン、例
えば、その他にもいろいろあるが、結腸ガン、乳ガン、肺ガン、膵臓ガン、肝細
胞ガン、腎臓ガン、黒色腫、肝転移、肺、乳房および前立腺転移のような転移ガ
ン、があげられる。本発明の組成物および調合物は、照射療法、化学療法、抗体
療法、光学療法およびガン、ならびにその他の型の外科手術を含むその他の治療
の前、間、および後の投与に適している。本発明の組成物および調合物もまた、
明らかな負の副作用を持つ療法の代替法として有効に投与することもできる。用
語「アンチセンス」オリゴヌクレオチドは、一般的に、一本鎖DNAに似た、小さ
い、合成されたオリゴヌクレオチドを指し、それは本特許では、標的メッセンジ
ャーRNA（mRNA）の阻害による遺伝子発現の阻害に適用される。Milligan，J．F
．ら、J．Med．Chem．，36（14），1923-1937、1993（その関連武分をここにそ
の全体を参照として採用する）を参照のこと。調和させるために、本特許内では
、すべてのRNAsおよびオリゴヌクレオチドを、左から右へ読む場合、5’から3’
方向への一本鎖として表すが、それらの相補性配列もまた本発明の四隅に包含さ
れる。さらに、すべてのヌクレオチド塩基およびアミノ酸は、IUPAC-IUB Bioche
mical Nomenclature Commissionの勧告、または（アミノ酸に関しては）既知
の3文字コード、を用いて表される。ヌクレオチド配列は、ここでは、5’から3
’方向での、左から右への、一本鎖のみによって示される。さらに、ヌクレオチ
ドおよびアミノ酸は、ここでは、IUPAC-IUB Biochemical Nomenclature Commi
ssionによって勧告された様式で、または（アミノ酸に関しては）、37CFR’1．8
22および確立された使用法に従って3文字コードを用いて、表される。例えば、P
atent In User Manual，99-102（1990年11月）（合衆国特許およびTrademark
Office，Ofice of the Assistant Commissioner for Patents，Washington，
D．C．20231）；合衆国特許第4，871，670号（Hudsonら、col．3，20-43行）を
参照のこと。本方法は、アンチセンス薬剤を用いて、以下の表1および2に列挙し
たそれらを含む、標的遺伝子の遺伝子発現を阻害するかまたはダウンレギュレー
トする。このことは、一般的には、この技術分野で既知のように、標的化メッセ
ンジャーRNA（mRNA）のコード（センス）配列へのアンチセンスオリゴヌクレオ
チドのハイブリダイゼーションによって成し遂げられる。内因的に投与された本
発明の薬剤は、標的遺伝子によってコードされるmRNAおよびタンパク質のレベル
を減少させる、および／または、これらの処理細胞の成長特徴または形態を変化
させる原因となる。Milliganら、1993；Helene，C．およびToulme，J．，Bioche
m．Biophys．Acta，1049，99-125、1990；Cohen，J．S．D．編、("Oligodeoxynu
cleotides as Anti-sense Inhibitors of Gene Expression")「遺伝子発現のア
ンチセンスインヒビターとしてのオリゴデオキシヌクレオチド」、CRC Press；B
oca Raton，FL，1987（その関連部分を、ここにその全体を参照として採用する
）を参照のこと。ここに用いられている、「アンチセンスオリゴヌクレオチドま
たはアンチセンスオリゴ」は、一般的に、（1）適当なハイブリダイゼーション
条件下で標的化タンパク質をコードするmRNAの任意のセグメントとハイブリダイ
ズする、そして（2）ハイブリダイズ時に、標的タンパク質の遺伝子発現の現象
の原因となる、合成ヌクレオチドの短い配列である。用語「desアデノシン」（d
esA）および「desチミジン」（desT）は、実質上アデノシンの欠損した（desA）
またはチミジンの欠損した（desT）オリゴヌクレオチドを指す。ある例では、de
sAまたはdesT配列は、天然発生であり、また一方では、アゴニストとして活性化
されるか、またはアデノシンAレセプター誘発効果を持つような、非所望活性を
欠くもう一つのヌクレオチドによって非所望のヌクレオチド（A）を置換するこ
とによって生じさせることができる。本状況下では、置換は、一般的にこの技術
分野で現在知られている、または後ほど確かめられる、「一般的たは代替の塩基
」でAを置換することによって成し遂げられる。ここで用いられている、用語「
防ぐ」「防いでいる」「治療する」または「治療している」は、そのような治療
を施された患者がアデノシンレセプター刺激と関連する症状を表すであろう可能
性を減らす、防御的、予防的、維持的または治療的処置を指す。用語「ダウンレ
ギュレーション」は、生成、分泌または効力の減少を誘導し、それによって、レ
セプター、例えばアデノシンA₁、A_2b、A₃、ブラディキニン2B、GATA-3またはそ
の他のレセプターである、細胞内標的生成物の濃度が減少する、またはアデノシ
ンA_2aレセプターの濃度が増加する、ことを指す。本技術は、肺気道病理学を含
む病気と関連するmRNAsを標的とするアンチセンスオリゴスの設計、および、そ
れらを修飾して、崩壊時にそれらがアデノシンを放出することを原因とする好ま
しくない副作用の発生を減少させ、それらの予定される目的にそれらの活性およ
び効き目を維持すること、頼っている。この方法では、発明者は、特定の遺伝子
を標的化し、相当するmRNAと選択的に結合する1以上のアンチセンスオリゴヌク
レオチドを設計し、必要であれば、次に、代替あるいは一般塩基、またはアデノ
シンA₁、A_2bあるいはA₃レセプターを活性化あるいはアンタゴナイズする、また
はアデノシンA_2aレセプターのアゴニストとして働くことのできる、能力を明ら
かに、または実質上減少させる能力を持たないアデノシン類似体、での置換を通
してそれらのアデノシン含有量を減少させる。存在する任意数のアデノシンを、
チミジン塩基とは結合するが、アデノシンA₁、A_2bおよびA₃レセプターのアデノ
シン塩基アゴニストまたはアンタゴニスト活性の約0．3より少ない活性を持つ、
ヘテロ芳香族塩基のような、代替および／または一般の塩基によって置換するこ
とができる。この分野での彼の以前の実験から、発明者は、特定の遺伝子を「ダ
ウンレギュレートする」ことに加えて、チミジン（T）を含まない、あるいはそ
の含有量が低い、または、代わりの方法として、チミジンとは結合するが、アデ
ノシン活性化能力を欠き、一方で肺内でのアデノシン収縮に影響を及ぼす、その
他のヌクレオチド塩基、いわゆる一般の塩基を持つ設計されたオリゴヌクレオチ
ド内に存在する1以上のアデノシンを置換した、いずれかの選択されたRNAセグメ
ントを投与された薬剤の効果を増加することができると、推論した。アデノシン
（A）はチミジン（T）に対して相補的なヌクレオチド塩基であることを考えに入
れると、1つのTがRNA内にある場合、アンチセンスオリゴは、同位置に一つのAを
持つであろう。

【００１２】 本発明の一つの態様では、アンチセンスオリゴヌクレオチドは、呼吸障害、ア
レルギー、肺炎症、肺サーファクタントの涸渇、肺サーファクタントの低下、気
道障害、気管支炎等と関連するタンパク質をコードするmRNA分子の部分またはセ
グメントと特異的に結合する、配列を持つ。この結合の一つの効果は、相当する
mRNAの翻訳を減少させるか、あるいは妨害し、それによって標的タンパク質の患
者肺内への到達量を減少させることにある。本発明の一つの好ましい実施態様で
は、アンチセンスオリゴヌクレオチドのホスホジエステル残基は、修飾または置
換されている。ホスホジエステル残基を、例えばメチルホスホネート、ホスホト
リエステル、ホスホロチオエート、ホスホロジチオエート、またはホスホロアミ
デート、に修飾または置換されたオリゴヌクレオチドの化学類似体、インビボで
のオリゴヌクレオチドの安定性を増加させる、α-メトキシエチルおよび類似修
飾が特に好ましい。オリゴヌクレオチドの自然発生のホスホジエステル結合は、
細胞ヌクレアーゼによって、ある程度、分解されやすい。反対に、本明細書で計
画された残基の多くは、ヌクレアーゼ分解に対して高い耐性を示す。Milliganら
；Cohen，J．S．D．、上記を参照のこと。本発明のもう一つの実施態様では、オ
リゴヌクレオチドの3’末端のホスホジエステル結合の代わりにヌクレアーゼ耐
性結合を用いて「3’-末端キャップ」を付加することによって、分解からオリゴ
ヌクレオチドを保護することができる。Tidd，D．M．およびWarenius，H．M．，
Be．J．Cancer，60，343ー350、1989；Shaw，J．P．ら、Nucleic Acids Res．
，19，747-750、1991（その関連部分を、ここにその全体を参照として採用する
）を参照のこと。ホスホロアミデート、ホスホロチオエート、およびメチルホス
ホネートは、α’メトキシエチル等のようなα’を修飾すると言ったような、本
発明の目的のために、この様式で十分にすべての機能を結合する。ホスホジエス
テル骨格の修飾が大規模であればあるほど、得られた薬剤はより安定になり、多
くの例では、それらのRNAアフィニティーおよび細胞浸透が高くなる。Milligan
ら、上記を参照のこと。さらに、炭水化物環への複数置換もまた、核酸の安定性
を改良することが知られている。このように、修飾または置換されうる残基の数
は、その必要性、標的および投与経路に依存して変化し、残基の1〜すべて、そ
の間の任意の数であることができる。新規の結合でホスホジエステル骨格全体を
置き換える別の方法は、数多く知られている。Millikanら、上記、を参照のこと
。好ましい骨格類似体残基には、ホスホロアミデート、ホスホロチオエート、メ
チルホスホネート、ホスホロトリエステル、ホスホトリエステル、チオホルムア
セタール、ホスホロジチオエート、ホスホロアミデート、ホルムアセタール、ト
リホルムアセタール、チオエーテル、カルバメート、ボラノホスフェート、3’-
チオホルムアセタール、5’-チオエーテル、カルボネート、C₅-置換ヌクレオチ
ド、5’-N-カルボネート、スルフェート、スルホネート、スルファメート、スル
ホンアミド、スルホン、スルファイト、2’-Oメチル、スルホキシド、スルフィ
ド、ヒドロキシアミン、メチレン（メチルイミノ）（MMI）、メトキシメチル（M
OM）およびメトキシエチル（MOE）、ならびにメチレンオキシ（メチルイミノ）
（MOMI）残基、およびその組み合わせ、が含まれる。ホスホロチオエートおよび
メチルホスホネート-修飾オリゴヌクレオチドは、自動オリゴヌクレオチド合成
を通してのそれらの入手しやすさにより、特に好ましい。Millikanら、上記、を
参照のこと。適当な場所に、本発明の薬剤を、それらの医薬として許容しうる塩
の形で、またはアンチセンスオリゴヌクレオチドおよびその塩の混合物として、
投与することができる。本発明のもう一つの実施態様では、異なるアンチセンス
オリゴヌクレオチドまたはそれらの医薬として許容しうる塩の混合物を投与する
。本発明の単一薬剤は、標的mRNAの発現を緩和する能力を持つ、および／または
さまざまな薬剤は経路での活性を強化または弱める能力を持つ。実施例では、標
的mRNAまたは遺伝子内に、約7またはそれより多くのモノヌクレオチド、好まし
くは最大で約60のモノヌクレオチド、より好ましくは、約10〜約36のモノヌクレ
オチド、さらにより好ましくは約12〜約21のモノヌクレオチドをそれぞれ含む、
チミジン（T）が少ないデオキシリボヌクレオチドセグメント、またはアデノシ
ン（A）が少ないデオキシヌクレオチドセグメントの可能なすべてを同定するこ
とによって、本方法を実施することができる。これは、標的配列内で、アデノシ
ンと相補的なヌクレオチドである、チミジン（RNA）が少ない、あるいは欠損し
ている、またはアデノシン（遺伝子）が少ない、7以上のヌクレオチド長である
、モノヌクレオチドセグメントを探すことによって、成し遂げられ得る。大部分
の場合、この検索は、典型的には、約10〜30のそのような配列、即ち、約40％以
下のアデノシンが天然に欠落しているか、または約40％以下のアデノシンを持ち
、平均の長さ、即ち約1800ヌクレオチド長、の典型的標的mRNAの長さを変化させ
たアンチセンスオリゴヌクレオチド、を結果として生ずる。TまたはAの含有量の
高いそれらは、それぞれ1以上のAを一般塩基で置き換えることによって、調整し
た。本発明の薬剤は、限定するつもりはないが、約7〜約60のヌクレオチド長、
好ましくは約12〜約45、より好ましくは約30のヌクレオチド長、さらにより好ま
しくは最大で21のヌクレオチド長を含む任意の適当な長さであることができるが
、それらは、特定の標的および送達用式に従って、また違う長さであっても良い
。本発明の薬剤を、標的RNAの任意のそしてすべてのセグメントに向けることも
できる。薬剤の一つの好ましい群は、イントロンとエキソンの間の接合部を含む
mRNA領域に向けられたそれらを含む。薬剤がイントロン／エキソン接合部に向け
られる場合、それは、接合部を全体的に覆うか、または接合部を充分に塞ぎ、前
駆体mRNAの成熟mRNAへのプロセシング中に、介在するエキソンの接合除去を防ぐ
ことができる、例えば、イントロン／エキソン接合部の、約2〜10、好ましくは
約3〜5ヌクレオチド内に位置するアンチセンスオリゴヌクレオチドの3’末端ま
たは5’末端、かのいずれかであることができる。また、開始コドンならびにコ
ード領域の5’末端および3’末端近くのそれらに重なる、アンチセンスオリゴヌ
クレオチドが好ましい。エキソンのフランキング領域もまた、前駆体mRNA内のス
プレイスさせるセグメントと共に、標的化することができる。アデノシンレセプ
ターおよび多くのその他の標的のmRNA配列を、レセプター、例えばアデノシンレ
セプター、酵素、ファクターまたは気道疾病と関連するその他の標的のいずれか
を発現する遺伝子のDNA塩基配列から誘導する。例えば、ゲノムのヒトA₁アデノ
シンレセプターの配列は、合衆国特許第5，320，963号（Stiles，G．ら）に開示
されている。A₃アデノシンレセプターをクローン化し、配列決定し、そしてラッ
ト（Zhou，F．ら、P．N．A．S．USA，89，7432、1992を参照のこと）およびヒト
（Jacobson．M．A．ら、英国特許出願No．9304582．1、1993を参照のこと）内で
発現させた。アデノシンA_2bレセプター遺伝子の配列もまた、既知である。Salva
tore，C．A．，Luneau，C．J．，Johnson，R．G．およびJacobson，M．，Genomi
cs、1995（その関連部分を、ここにその全体を参照として採用する）を参照のこ
と。残る多くの例示的標的遺伝子の配列もまた既知である。GenBank，NIHを参照
のこと。配列が未だ入手できないそのような遺伝子の配列は、この技術分野で既
知の技術を適用して標的セグメントを単離することによって得ることができる。
一度、遺伝子、そのRNAおよび／またはタンパク質の配列が分かったならば、ア
ンチセンスオリゴヌクレオチドを、上記の方法に従って本発明によって作成し、
標準技術に従って、標的となるタンパク質の生成を減少させることができる。ア
デノシンA_2aブラディキニンおよびその他の遺伝子の配列ならびにオリゴヌクレ
オチドの調製方法は、本発明が適当である、多くのその他の標的遺伝子およびmR
NAの調製方法として知られている。従って、アデノシンA₁、A_2a、A_2b、A₃、ブラ
ディキニン、GATA-3、COX-2、および数多くのその他のレセプターを含む、気道
疾病と関連する標的配列の生成をダウンレギュレートするアンチセンスオリゴヌ
クレオチドを、標準的技術に従って作成することができる。本方法での治療に適
している病気および病状の例としては、急性呼吸窮迫症候群（ARDS）：喘息：な
らびに、例えば、上部心室性貧弱（SVT）およびその他の不整脈の治療、ならび
に過敏性個体、虚血、ある薬品によって誘発される腎臓障害または腎不全、新生
児呼吸窮迫症候群、痛み、嚢胞性線維症、肺高血圧、肺血管収縮、気腫、慢性閉
塞性肺疾患（COPD）、肺移植切除、肺感染症、および白血病、リンパ腫、カルシ
ノーマ等のようなガン、例えば、その他にもいろいろあるが、結腸ガン、乳ガン
、肺ガン、膵臓ガン、肝細胞ガン、腎臓ガン、黒色腫、肝転移等、ならびに乳房
および前立腺ガンを含む、肺に転移する可能性のあるかまたは転移したすべての
型のガンに対するストレステストにおけるアデノシン投与：を含む、病気および
病状があげられる。

【００１３】 上記のアデノシンレセプターは、発明者の技術が高い効果を発揮する単なる例
にすぎない。事実、多数の遺伝子を本薬剤によって同様の方法で標的化し、タン
パク質発現を減少またはダウンレギュレートすることができる。標的の病気また
は病状が、呼吸妨害または呼吸縮小、気管支収縮、慢性気管支炎、肺気管支収縮
および／または高血圧、慢性閉塞性肺疾患（COPD）、肺移植切除、肺感染症、ア
レルギー、喘息、嚢胞性線維症、呼吸窮迫症候群、直接または転移によって肺に
罹患するかいずれかのガン、と関連する一つであるならば、本方法を、その他に
もいろいろあるが、以下の表1および表2に列挙した標的を含む、潜在的標的mRNA
のリストに適用することができる。本発明のアンチセンス薬剤は、A含有量が低
く、インビボでの薬剤分解時のその放出を防ぐ。例として、例えば、系が肺また
は呼吸系であれば、以下の表1に列挙されたそれらを含む多数の遺伝子が、別の
機能に含まれる。

【００１４】

【表１】

【００１５】 これらの遺伝子、およびその他の遺伝子は、呼吸の正常な機能、ならびに、嚢
胞性線維症、喘息、肺高血圧および血管収縮、慢性閉塞性肺疾患（COPD）、肺移
植切除、肺感染症、慢性気管支炎、呼吸窮迫症候群（ARDS）、アレルギー性、肺
ガンおよび肺転移ガンおよび炎症性応答を持つそれらを含むその他の気道疾病を
含む、呼吸病理学と関連する疾病内に含まれる。

【００１６】 標的レセプター、例えば、その他にもいろいろあるが、アデノシンA₁、A_2a、A _2b およびA₃レセプター、CCR3（ケモキンレセプター）、ブラディキニン2B、CAM
（血管細胞接着分子）、および好酸球レセプターに対するアンチセンスオリゴは
、それらの遺伝子の発現のダウンレギュレートに有効であることが示されている
。これらの内のいくつかは、例えば、アデノシンA₁、A_2a、A_2bおよび／またはA₃ レセプターおよびCCR3、ブラディキニン2B、VCAM（血管細胞接着分子）および好
酸球レセプターの「ダウンレギュレーション」によって、症状を緩和する、また
は呼吸系の病気および炎症を減少させるように作用する。これらの薬剤を、本方
法単独で、またはその他の遺伝子を標的としたアンチセンスオリゴヌクレオチド
を合わせて利用し、それらが含まれる経路および／またはネットワークに効力を
発生させることができる。よりよい結果を得るために、好ましくは、オリゴスを
、例えば吸息またはその他の手段で、実験動物の呼吸系内に直接投与し、そうす
ることによって、オリゴスを全身に広く散布することなく肺に到達させることが
できる。このことにより、それらの全身投与、または一般的経路と比較して低い
薬剤投与量で用いることが可能になり、結果として、身体への薬剤の広範囲分布
により生じる望ましくない副作用の数および程度を減少させることができる。本
発明の薬剤は、組織によって発現するレセプタータンパク質の量を減少すること
が分かっている。これら薬剤は、従って、それらの標的、例えばレセプターと単
に作用するのみと言うよりはむしろ、その他の薬剤が作用することのできる標的
タンパク質の数を低下させる。このように、本薬剤は、毒性が低く非常に高い効
果を与える。とりわけ、A₁、A_2b、A₃、ブラディキニンB2、GATA-3、CAM（血管細
胞接着分子）、好酸球レセプターおよびCOX-2レセプターに対するアンチセンス
オリゴヌクレオチドは、細胞内のそれぞれのレセプタータンパク質のダウンレギ
ュレーションに効果的であることが分かった。アデノシン仲介気管支収縮の慣用
的治療法と比較して、この治療法の一つの新しい特徴は、投与を肺に直接、また
はその他の組織、器官あるいは全身の使用位置に行うことである。さらに、レセ
プタータンパク質自身は、単に薬剤と作用するというよりはむしろ、その量を減
少させ、そしてその毒性を減少させる。肺の状態を治療するアンチセンス薬剤で
標的化されうるその他のタンパク質には、限定するつもりはないが、CCR3（ケモ
キン）レセプター、ヒトA_2aアデノシンレセプター、ヒトA_2bアデノシンレセプタ
ー、ヒトIgEレセプターβ、ヒトFc-εレセプターCD23抗原、ヒトヒスチジンデカ
ルボキシラーゼ、ヒトβトリプターゼ、ヒトトリプターゼ-I、ヒトプロスタグラ
ンジンDシンターゼ、ヒトシクロオキシゲナーゼ-2、ヒト好酸球カチオンタンパ
ク質、ヒト好酸球誘導神経毒、ヒト好酸球ペルオキシダーゼ、ヒト細胞間接着分
子（IACM-1）、ヒト血管細胞接着分子（VCAM-1）、ヒト白血球内皮接着分子-1（
ELAM-1）、ヒトP選択、ヒト単球内皮活性化因子1、ヒトIL-3、ヒトIL-4、ヒトIL
-5、ヒトIL-6、ヒトIL-8、ヒト単球誘導好中球走化性因子、ヒト好中球エラスタ
ーゼ、ヒト好中球オキシダーゼ因子、ヒトカテプシンG、ヒトデフェンシン1、ヒ
トデフェンシン3、ヒトマクロファージ炎症性タンパク質-1α、ヒトムスカリン
性アセチルコリンレセプターHM3、ヒトフィブロネクチン、ヒトGM-CSF、ヒト腫
瘍壊死因子α、ヒトロイコトリエンC4シンターゼ、ヒト主要塩基性タンパク質、
およびヒトエンドセリン1が、含まれる。限定するつもりはないが、より広範な
遺伝子リストを以下に提供する。これらのいくつかは、例えば、アデノシンA₁、
A_2a、A_2b、 および／またはA₃レセプターならびにCCR3、ブラディキニン2B、VC
AM（血管細胞接着分子）および好酸球レセプターの「ダウンレギュレーション」
により、症状を緩和する、または呼吸系の病気および／または炎症を減少させる
ように作用する。好ましくは、例えば吸息またはその他の手段で、これら薬剤を
直接呼吸系に投与し、そうすることによって、全身に広く拡散することなく、薬
剤を肺に到達させることができる。このことにより、それらを先行技術によって
全身に、あるいはその他の一般的経路によって投与する場合と比較して、本発明
の薬剤を実質上低い投与量で用いることが可能になり、結果として、薬剤が全身
に広く拡散することから生じる非所望の副作用が減少する。本発明の薬剤は、組
織によって発現するレセプタータンパク質の量を減少させることが分かった。従
って、これらの薬剤は、単にそれら標的、例えばレセプターと相互作用すると言
うよりはむしろ、その他の薬剤が作用しうる標的タンパク質の数を低下させる。
このように、本薬剤は、低毒性で極めて高い効果を提供する。これらの後者の標
的内、および一般的標的遺伝子内では、特に、アデノシン放出からそれらの崩壊
生成物を守るために、相当するアンチセンスオリゴヌクレオチドのアデノシン含
有量を排除または減少させることが特に必要である。

【００１７】 ここに用いられている、用語、喘息を「治療する」または「治療している」は
、そのような治療を受けた患者が肺疾病の症状を表すであろう可能性を減少させ
る治療を指す。用語「ダウンレギュレート」は、標的とされる細胞内タンパク質
の生成、分泌または有効性の減少（その結果としての濃度の減少）の誘導を指す
。本発明は、主に、ヒト患者の治療と関係している。しかしながら、ここに開示
された薬剤および方法は、ウシ、ウマ、野生動物、動物園動物および飼育動物、
例えばイヌおよびネコ、の様なその他の動物の治療における場合のように、家畜
の病気の治療目的でも用いることができる。標的タンパク質は、好ましくは哺乳
動物、より好ましくは治療される患者と同一種のタンパク質である。一般に、「
アンチセンス」は、標的メッセンジャーRNA（mRNA）の機能を阻害することによ
って遺伝子発現を阻害する、一本鎖DNAに似た、小分子の合成オリゴヌクレオチ
ドを用いることを指す（Milligan，J．F．ら、J．Med．Chem．，36（14）、1923
-1937、1993）。本発明では、A₁またはA₃アデノシンレセプターの遺伝子発現の
阻害が望ましい。遺伝子発現は、ワトソン-クリックの塩基対法則に従って、水
素結合によって特定のメッセンジャーRNA（mRNA）標的内のコード配列（センス
）とハイブリダイズすることを通して、阻害される。アンチセンス阻害の機構は
、適用された外因性オリゴヌクレオチドが標的遺伝子のmRNAおよびタンパク質レ
ベルを減少させる、または細胞の増殖特性あるいは形態を変化させる原因となる
ことである。また、Helene，C．およびToulme，J．，Biochim．Biohys．Acta．
，1049、99-125、1990；Cohen，J．S．D．編、「遺伝子発現のアンチセンスイン
ヒビターとしてのオリゴデオキシヌクレオチド」("Oligodeoxynucleotides as A
nti-sense Inhibitors of Gene Expression")、CRC Press、Boca Raton，FL、1
987、もまた、参照のこと。ここに用いられている「アンチセンスオリゴヌクレ
オチド」は、（1）下記のハイブリダイゼーション条件に従って、標的タンパク
質をコードするmRNA内の任意のコード配列とハイブリダイズし、そして（2）ハ
イブリダイゼーションにより、A₁またはA₃アデノシンレセプターの遺伝子発現の
減少原因となる、合成ヌクレオチドの短い配列と、定義される。上記のレセプタ
ーは、本技術の高力価の単なる例に過ぎない。事実、本方法を実施することによ
るのと類似した方法で、多数の遺伝子を標的化し、タンパク質発現を有意にダウ
ンレギュレートまたは抹消し、そして、系内、例えば呼吸系およびその他の肺疾
病に関する標的、での1以上の機能に対して任意の変化を認めることができる。
実施例によって、呼吸系内では、標的は、呼吸困難、気管支収縮、炎症、アレル
ギー性 、慢性気管支炎、サーファクタント涸渇、ならびに、慢性閉塞性肺疾患
（COPD）、肺移植切除、肺感染症、ハレーション熱傷、急性呼吸窮迫症候群（AR
DS）、嚢胞性線維症、肺線維症、肺照射、扁桃炎、気腫、歯痛、口内炎、関節痛
、食道炎、肺ガン、食道ガン等のような直接的、または、とりわけ転移による間
接的、のいずれかの呼吸系を冒すガン、の様な病気および病状と関連するその他
疾病、の難しさと関係するであろう。これらの機能は、喘息、アレルギー、アレ
ルギー性、肺気管支収縮および高血圧、慢性閉塞性肺疾患（COPD）、肺移植切除
、肺炎、アレルギー、喘息、嚢胞性線維症（CF）、急性呼吸窮迫症候群（ARDS）
、ならびに新生児および胎児関連RDS、直接的にあるいは転移により肺を冒すガ
ン等の場合のように、呼吸障害を持つそれらの関連性故に、非常に興味がある（
本アンチセンスオリゴヌクレオチドは、その他にもいろいろあるが、上記表1に
列挙した標的を含む、標的mRNAのリストに示されている）。

【００１８】 本発明のオリゴスは、最初、GおよびCよりなる群より選択された少なくとも4
の連続核酸を持つ、および／または特定の型および／または程度の活性を持つ、
標的核酸のフラグメントを選択し、次に、選択されたフラグメントを含み、且つ
チミジン（T）核酸含有量が、最大で約15％、好ましくは約12％、約10％、約7％
、約5％、約3％、約1％、より好ましくはチミジンを含まない、4〜60のヌクレオ
チド長の第一オリゴヌクレオチドを得ることによって、得られる。後者のステッ
プは、選択されたフラグメントに対するアンチセンスである配列を含む4〜60の
ヌクレオチド長の第二オリゴヌクレオチドを得る助けとなり、その第二オリゴヌ
クレオチドは、アデノシン塩基含有量が最大で約15％、好ましくは約12％、約10
％、約7％、約5％、約3％、約1％、より好ましくはアデノシンを含まない。選択
されたフラグメントが少なくとも1つのチミジン塩基を含む場合、相当するアン
チセンスヌクレオチドフラグメント内のアデノシン塩基を、ヘテロ芳香族塩基か
らなる基より選択された一般塩基を持つ相当するアンチセンスヌクレオチドフラ
グメントに置換することができ、このヘテロ芳香族塩基は、チミジン塩基と結合
するが、アデノシンA₁、A_2a、A_2bおよびA₃レセプターでのアデノシン塩基アゴニ
スト活性は、約10％より少なく、好ましくは約1％より少なく、より好ましくは
約0．3％より少なく、また、ヘテロ芳香族塩基は、呼吸系内で実証すると、アデ
ノシンA_2aレセプターで活性を持たない。その他の系内での他のアデノシン活性
は、適当に、別の系内で測定することができる。ヘテロ芳香族塩基類似体を、O
、ハロ、NH₂、SH、SO、SO₂、SO₃、COOHによって置換され、分枝化され、そして
一級および二級アミノ、アルキル、アルケニル、アルキニル、シクロアルキル、
ヘテロシクロアルキル、、アリール、ヘテロアリール、アルコキシ、アルケノキ
シ、アシル、シクロアシル、アリールアシル、アルキノキシ、シクロアルコキシ
、アロイル、アリルチオ、アリルスルホキシル、ハロシクロアルキル、アルキル
シクロアルキル、アルケニルシクロアルキル、アルキニルシクロアルキル、ハロ
アリール、アルキルアリール、アルケニルアリール、アルケニルアリール、アリ
ールアルキル、アリールアルケニル、アリールシクロアルキルと融合し、さらに
O、ハロ、NH₂、一級、二級および三級アミン、SH、SO、SO₂、SO₃、シクロアルキ
ル、ヘテロシクロアルキルおよびヘテロアリールで置換されうる、すべてのピリ
ミジンおよびプリンから選択することができる。この技術分野で既知なように、
すべての位置で、ピリミジンおよびプリンを置換することができるが、位置1、2
、3、4、7および／または8を置換されたそれらが好ましい。化学式

【００１９】

【化３】

【００２０】 （式中、R¹およびR²は、独立的に、H、アルキル、アルケニルまたはアルキニル
であり、R³ は、他にもいろいろあるが、H、アリール、ジシクロアルキル、ジシ
クロアルケニル、ジシクロアルキニル、シクロアルキル、シクロアルケニル、シ
クロアルキニル、O-シクロアルキル、O-シクロアルケニル、O-シクロアルキニル
、NH₂-アルキルアミノ-ケトキシアルキルオキシ-アリール、モノおよびジ-アル
キルアミノアルキル-N-アルキルアミノ-SO₂アリールである）を持つ、テオフィ
リン、カフェイン、ディフィリン、エトフィリン、アセフィリンピペラジン、バ
ミフィリン、エンプロフィリンおよびキサンチンの様な、ピリミジンおよびプリ
ンが、より好ましい。糖部分の同様の修飾もまた、本発明の実施態様内にある。
標的RNA内に存在するチミジン（T）と関連するアンチセンスオリゴスのアデノシ
ン含有量を減少させると、系内、例えば肺、脳、心臓、腎臓等、組織環境内にア
デノシンを放出する生成物内のオリゴスの崩壊を防ぎ、従って、それによる任意
の非所望の効果を防ぐことに役立つ。実施例によって、Nf6B転写因子を、標的と
して選択し、そのmRNAまたはDNAを、低チミジン（T）またはデスチミジン（desT
）フラグメントから探し出した。mRNAまたはDNAのdesTセグメントのみを選択す
ると、順番にそれらの相補鎖としてdesAアンチセンスを生成するであろう。多数
のRNA desTセグメントが見つかった場合、アンチセンスセグメントの配列を推定
することができる。典型的には、約10-30およびより多数のdesAアンチセンス配
列を得ることができる。これらのアンチセンス配列は、上記表1、下記表2に示し
たそれら、および、その他にもいろいろあるが脳、心臓血管および腎臓系の機能
と関連するその他のいずれかのような、標的のmRNAのdesTセグメントと関連する
いくつかまたはすべてのdesAアンチセンスオリゴヌクレオチド配列を含むことが
できる。これが起こる場合、認められたアンチセンスオリゴヌクレオチドは、10
0％Aを含まないと言える。標的遺伝子、例えばNF6B転写因子、と関連するオリジ
ナルのdesAアンチセンスオリゴヌクレオチド配列のそれぞれについて、典型的に
は約10〜30の配列が、チミジン含有量の低い（RNA）標的遺伝子またはRNA内で見
つかっている。本発明に従って、選択されたフラグメント配列もまた、二次また
は三次または四次配列内に少数のチミジン（RNA）ヌクレオチドを含むであろう
。ある場合には、アデノシン含有量が高くても、標的に対して活性が小さいまた
は不活性でさえあるアンチセンスオリゴヌクレオチドを与えるに充分であること
もある。本発明では、これらのいわゆる「不完全desA」配列は、好ましくは、約
15％、約12％、約10％、約7％、約5％および約2％のアデノシンより少ないアデ
ノシン含有量を持つであろう。最も好ましくは、アデノシン含有量が0％である
。しかしながら、いくつかの例では、より高いアデノシン含有量も受け入れ可能
であり、それでもなお、オリゴヌクレオチドは、有害な「アデノシン活性」を示
さない。特に重要な実施態様は、アデノシンヌクレオチドを「固定」する、また
は天然DNAに存在する、A、G、CおよびTの4ヌクレオチドの内の2つ以上と類似ま
たは等価なアフィニティーで塩基対合することのできる「一般または代替」塩基
で置換する場所である。

【００２１】 本特許では、一般のまたは代替塩基を、チミジンとハイブリダイズする実質的
能力を持つが、同時に、アデノシンが実験動物または細胞系内に望ましくない副
作用を及ぼす可能性のあるアデノシンレセプターまたはその他の分子と結合する
する能力が減少している、または実質上欠落している、任意化合物、より共通に
は、アデノシン類似体、と定義する。代わりに、アデノシンA₁、A_2bおよびA₃レ
セプター、最も好ましくはA₁レセプター、およびアデノシンA_2aレセプターのア
ゴニストとしてさえ作用するそれらのような、アデノシンレセプターを全く活性
化できない、または活性化する能力が明らかに減少したアデノシン類似体を、用
いることもできる。一般塩基の一つの例は、α-デオキシリボフラノソル-（5-ニ
トロインドール）であり、技術者は、その他を選択する方法を知っているであろ
う。この「固定」段階は、さらに天然に認められるアンチセンスに対してそれら
のアンチセンスと異なり、アンチセンスオリゴヌクレオチドが標的RNAと好まし
くは等しく良く結合することを可能にする、新規の配列を生成する。一般または
代替塩基のその他の例は、2-デオキシリボシル-（5-ニトロインドール）である
。一般塩基のその他の例は、3-ニトロピロール-2’-デオキシヌクレオシド、5-
ニトロ-インドール、2-デオキシリボシル-（5-ニトロインドール）、2-デオキシ
リボフラノシル-（5-ニトロインドール）、2’-デオキシイノシン、2’-デオキ
シネブラリン、6H，8H-3，4-ジヒドロプリミド［4，5-c］オキサジン-7-オンお
よび2-アミノ-6-メトキシアミノプリンである。上記に加えて、ハイブリダイゼ
ーション能力が幾分減少するが、任意のその他の塩基の代わりに置換することの
できる一般塩基には、3-ニトロピロール 2’-デオキシヌクレオシド 2-デオキ
シフラノシル-（5-ニトロインドール）、2’-デオキシイノシンおよび2’-デオ
キシネブラリン（Glen Research、Sterling，VA）が含まれる。より特異的な誤
対合修復は、他にもいろいろあるが、グアニン（G）またはアデニン（A）のいず
れかと塩基対合する、”P”ヌクレオチド（6H，8H-3，4-ジヒドロピリミド［4，
5-c］［1，2］オキサジン-7-オン）を、そしてシチジン（C）またはチミジン（T
）のいずれかとの塩基対では、”K”ヌクレオチド（2-アミノ-6-メトキシアミノ
プリン）を、用いて作ることができる。この技術分野で既知であるか、または入
手できるようになるであろうその他もまた、適している。例えば、Loakes，D．
およびBrown，D．M．，Nucl．Acids．Res．，22，4039-4043、1994；Ohtsuka，E
．ら、J．Biol．Chem．，260（5），2605-2608、1985；Lin，P．K．T．およびBr
own，D．M．，Nucleic Acids Res．，20（19），5149-5152、1992；Nichols，R
．ら、Nature，369（6480），492-493，1994；Rahmon，M．S．およびHumayun，N
．Z．，Mutation Research、377（2），263-8、1997；Amosova，O．ら、Nuclei
c Acids Res．，25（10），1930-1934，1997；Loakes，D．＆ Brown，D．M．
，Nucleic Acids Res．，22（20），4039-4043、1994（一般塩基およびそれら
の調製および核酸結合における使用に関連する部分全体を、ここに参照として採
用する）を参照のこと。天然発生標的内に完全でないdesT配列が見つかった場合
、典型的には、それらを選択し、そうすることによって約1〜3の一般塩基置換で
、100％”desA”アンチセンスオリゴヌクレオチドを得ることができるであろう
。このように、本方法は、A含有量が低いかまたは含まれない異なる標的に対す
るアンチセンスオリゴヌクレオチド、ならびに、例えば約1〜3、あるいはそれよ
り多くの1以上のアデノシンオリゴヌクレオチドが、「一般」または「置換」塩
基で置換されることによって、「固定化」されているアンチセンスオリゴヌクレ
オチドのいずれかを提供する。一般塩基はこの技術分野では既知であり、ここに
列挙する必要はない。技術者は、どの塩基が一般塩基として作用し、Aの代わり
にそれらで置き換えることができるかを、知っているであろう。以下の表2は、
本発明の薬剤が効果的に適用される、標的の選択数を提供している。しかしなが
ら、その他もまた、標的化することができる。

【００２２】

【表２】

【００２３】 ガン治療に好ましい標的群は、任意の異なる型のガンと関連する遺伝子、また
は、調節するか、あるいはRNAおよび／またはタンパク質の生成に含まれるかの
いずれかの、一般に悪性と関連することが知られているそれら、である。例とし
ては、限定するつもりはないが、その他にもいろいろあるが、ras、src、myc、
およびBCL-2を含む、トランスフォーミングガン遺伝子があげられる。その他の
標的は、さまざまな酵素、主に、限定するつもりはないが、チミジレートシンタ
ーゼ、ジヒドロホレートレダクターゼ、チミジンキナーゼ、デオキシシチジンキ
ナーゼ、リボヌクレオチドレダクターゼ等の様な、現在のガン走化性薬剤を向け
られるそれらである。本技術は、慣用のガン治療が、化学療法、放射線療法等の
ような治療の破滅的効果から正常な生きた細胞を保護しつつ、ガン細胞を選択的
に殺すという未解決の問題と戦っている限りにおいて、特にガン疾病の治療に有
効である。本技術は、望ましい経路または標的を選択的に弱めるまたは強める能
力を提供する。この研究は、一般的には正常細胞では同時に発現しない、一次、
二次さらに可能であれば三次の標的を含む経路を選択できるため、標準的なガン
治療法以上の有意の利益を提供する。従って、本薬剤を患者に投与すると、例え
ば3つの標的すべてを発現している腫瘍細胞内では毒性が選択的に増加する原因
となるが、これに対して、1または2のみの標的を発現しているであろう正常細胞
では、明らかに影響が少ない、または影響を与えない場合もある。ガン治療に好
ましい標的群は、異なる型のガンと関連する遺伝子、または悪性腫瘍と関連する
ことが一般に知られているそれらであり、それらはRANおよび／またはタンパク
質を生成を調節するか、またはその生成に含まれる。例としては、限定するつも
りはなく、その他にもいろいろあるが、ras、src、mycおよびBCL-2を含む、形質
転換ガン遺伝子があげられる。その他の標的は、現在のガン化学療法薬剤が向け
られる、さまざまな酵素、主に、限定するつもりはないが、チミジレートシンセ
ターゼ、ジヒドロホレートレダクターゼ、チミジンキナーゼ、デオキシシチジン
キナーゼ、リボヌクレオチドレダクターゼのような、それらである。

【００２４】 一つの実施態様では、本発明のオリゴが標的とする少なくとも一つのmRNAsは
、他にもいろいろあるが、転写因子、刺激および活性化因子、細胞内および細胞
外レセプターならびにペプチド伝達物質、一般に、インターロイキン、インター
ロイキンレセプター、ケモカイン、ケモカインレセプター、内因的に生成される
特異的および非特異的酵素、イムノグロブリン、抗体レセプター、中枢神経系（
CNS）ならびに末梢神経および非神経系レセプター、CNSおよび末梢神経および非
神経系ペプチド伝達物質、接着分子、ディフェンシン、成長因子、バソアクティ
ブペプチドおよびレセプター、ならびに結合タンパク質の様なタンパク質をコー
ドする；または、mRNAは、ガン遺伝子、およびさまざまな病気または病状と関連
するその他の遺伝子と関連する。標的タンパク質の例としては、その他にもいろ
いろあるが、エオタキシン、主要塩基性タンパク質、プレプロエンドセリン、好
酸球カチオンタンパク質、P-選択、STAT4、MIP-1α、MCP-2、MCP-3、MCP-4、STA
T6、c-mas、NF-IL-6、シクロフィリン、PDG2、シクロスポリンA-結合タンパク質
、FK5-結合タンパク質、フィブロネクチン、LFA-1（CD11a／CD18）、PECAM-1、C
3bi、PSGL-1、CD-34、サブスタンスP、p150，95、Mac-1（CD11b／CD18）、VLA-4
、CD-18／CD11a、CD11b／CD18、C5a、CCR1、CCR2、CCR4、CCR5およびLTB-4であ
る。しかしながら、その他も、同様に適当である。もう一つの実施態様では、オ
リゴが標的とする少なくとも1つのmRNAsは、その他にもいろいろあるが、交感神
経作用レセプター、副交感神経レセプター、GABAレセプター、アデノシンレセプ
ター、ブラディキニンレセプター、インスリンレセプター、グルカゴンレセプタ
ー、プロスタグランジンレセプター、甲状腺レセプター、アンドロゲンレセプタ
ー、同化レセプター、エストロゲンレセプター、プロゲステロンレセプター、凝
固経路と関連するレセプター、腺下垂体レセプター、腺下垂体ペプチド伝達物質
、およびヒスタミンレセプター（HisR）の様な、細胞内および細胞外レセプター
およびペプチド伝達物質をコードする。しかしながら、その他もまた考えられる
。コードされた交感神経作用レセプターおよび副交感神経レセプターには、アセ
チルコリンエステラーゼレセプター（AcChaseR）、アセチルコリンレセプター（
AcChR）、アトロピンレセプター、ムスカリン様レセプター、エピネフィリンレ
セプター（EpiR）、ドーパミンレセプター（DOPAR）、およびノルエピネフリン
レセプター（NEpiR）が、含まれる。コードされたレセプターのさらなる例とし
ては、アデノシンA₁レセプター、アデノシンA₂Bレセプター、アデノシンA₃レセ
プター、内皮レセプターA、内皮レセプターB、IgE高アフィニティーレセプター
、ムスカリンアセチルコリンレセプター、サブスタンスPレセプター、ヒスタミ
ンレセプター、CCR-1 CCケモカインレセプター、CCR-2 CCケモカインレセプター
、CCR-3 CCケモカインレセプター（エオタキシンレセプター）、インターロイキ
ン-1βレセプター（IL-1βR）、インターロイキン-1レセプター（IL-1R）、イン
ターロイキン-1βレセプター（IL-1βR）、インターロイキン-3レセプター（IL-
3R）、CCR-4 CCケモカインレセプター、システイニルロイコトリエンレセプター
、プロスタノイドレセプター、GATA-3転写因子レセプター、インターロイキン-1
レセプター（IL-1R）、インターロイキン-4レセプター（IL-4R）、インターロイ
キン-5レセプター（IL-5R）、インターロイキン-8レセプター（IL-8R）、インタ
ーロイキン-9レセプター（IL-9R）、インターロイキン-11レセプター（IL-11R）
、ブラディキニンB2レセプター、交感神経作用レセプター、副交感神経レセプタ
ー、GABAレセプター、アデノシンレセプター、ブラディキニンレセプター、イン
スリンレセプター、グルカゴンレセプター、プロスタグランジンレセプター、甲
状腺レセプター、アンドロゲンレセプター、同化作用レセプター、エストロゲン
レセプター、プロゲステロンレセプター、凝固経路に関連するレセプター、腺下
垂体レセプターおよびヒスタミンレセプター（HisR）が挙げられる。また、ここ
に列挙していない、その他もまた考えられる。本発明のオリゴス開発用のコード
酵素には、その他にもいろいろあるが、シンセターゼ、キナーゼ、オキシダーゼ
、ホスファターゼ、レダクターゼ、多糖、トリグリセリド、およびタンパク質ヒ
ドロラーゼ、エステラーゼ、 ならびに、多糖、トリグリセリド、脂質およびタ
ンパク質シンターゼ、が含まれる。標的酵素の例としては、その他にもいろいろ
あるが、トリプターゼ、誘導酸化窒素シンターゼ、シクロオキシゲナーゼ（Cox
）、MAPキナーゼ、好酸球ペルオキシダーゼ、β2-アドレナリン作用性レセプタ
ーキナーゼ、ロイコトリエンc-4シンターゼ、5-リポオキシゲナーゼ、ホスホジ
エステラーゼIV、メタロプロテイナーゼ、トリプターゼ、CSBP／p38 MAPキナー
ゼ、好中球エラスターゼ、ホスホリパーゼA₂、シクロオキシゲナーゼ2（Cox-2）
、フコシルトランスフェラーゼ、キマーゼ、プロテインキナーゼC、チミジレー
トシンセターゼ、ジヒドロホレートレダクターゼ、チミジンキナーゼ、デオキシ
シチジンキナーゼ、およびリボヌクレオチドレダクターゼが挙げられる。しかし
ながら、疾病または病状と関連する如何なる酵素もまた、本発明の標的として適
当である。本発明の適用に適当なコード因子は、その他にもいろいろあるが、Nf
6B転写因子、顆粒球マクロファージコロニー刺激因子（GM-CSF）、AP-1転写因子
、GATA-3転写因子、単球活性化因子、好中球走化性因子、顆粒球／マクロファー
ジコロニー-刺激因子（G-CSF）、NFAT転写因子、血小板活性化因子、腫瘍壊死因
子α（TNFα）、および塩基性繊維芽細胞成長因子（BFGF）である。特別に言及
しないが、さらなる因子もまた本発明内にある。本発明で用いられる適当な接着
分子には、細胞内接着分子1（ICAM-1）、2（ICAM-2）および3（ICAM-3）、血管
細胞接着分子（VCAM）、白血球内皮接着分子-1（ELAM-1）、好中球接着レセプタ
ー、mad CAM-1等、が含まれる。その他の既知のおよび（この時点で）未知の因
子もまた、ここに標的とすることができる。サイトカイン、リンホカインおよび
ケモカインの中では、インターロイキン-1（IL-1）、インターロイキン-1β（IL
-1β）、インターロイキン-3（IL-3）、インターロイキン-4（IL-4）、インター
ロイキン-5（IL-5）、インターロイキン-8（IL-8）、インターロイキン-9（IL-9
）、インターロイキン-11（IL-11）、CCR-5 CCケモカイン、およびランテス(Ran
tes)が望ましい。しかしながら、治療される特定の疾病または病状、または炎症
のような一般活性に含まれることが知られているような、その他もまた、標的と
することができる。本発明実施用のデフェンシンの例としては、デフェンシン1
、デフェンシン2、およびデフェンシン3が挙げられ、選択の例としては、α4β1
選択、α4β7選択、LFA-1選択、E-選択、P-選択、およびL-選択が挙げられる。
ガン遺伝子の例としては、リストにすべて含まれるわけではないが、ras、src、
mycおよびbcBCLである。しかしながら、本発明での使用には、その他もまた適当
である。

【００２５】 本発明に従って投与される薬剤は、好ましくは、投与されるはずである種に対
するオリジンと関連する標的遺伝子および／またはmRNAに対してアンチセンスで
あるように、設計される。ヒトを治療する場合、薬剤は、好ましくは、ヒト遺伝
子またはRNAに対してアンチセンスであるように設計される。本発明の薬剤は、
天然発生のDNAおよび／またはRNA配列、標的配列より最大で1塩基少ない長さ、
好ましくは少なくとも約7ヌクレオチド長であるそのフラグメント、約0．02％以
上、より好ましくは約0．1％以上、さらにより好ましくは約1％以上、さらによ
りこのましくは4％以上のアデノシンヌクレオチドのみ、および、最大で約30％
、より好ましくは最大で約15％、さらにより好ましくは最大で約10％、なおより
好ましくは最大で約5％アデノシンヌクレオチドを持つ、または全くアデノシン
を欠く、オリゴス；ならびに1以上のアデノシンヌクレオチドがいわゆる一般塩
基で置き換えられ、チミジンヌクレオチドと対合するが、実質上アデノシンレセ
プター活性を誘発できないオリゴス：に対してアンチセンスであるオリゴヌクレ
オチドを包含する。限定するつもりはないが、本発明のアンチセンスオリゴヌク
レオチドのヒト配列およびフラグメントの例としては、以下のフラグメントなら
びにフラグメントおよび全遺伝子またはmRNAコード配列のより短いセグメント、
好ましくは、それぞれの配列の7、10、15、18〜21、24、27、30、n−1（nは、配
列の全ヌクレオチド数である）のヌクレオチドを包含するエキソンおよびイント
ロン-エキソン接合部である。これらのフラグメントは、より長いオリゴ、例え
ばオリジナル配列の任意のその他の部位の中央、5’-末端、3’-末端または開始
部位、の任意の部分から選択されうる。特に重要なのは、低アデノシンヌクレオ
チド含有量のフラグメント、即ち、本発明による選択または一般塩基での置換の
いずれかによる、約30％またはそれより少ない、好ましくは約15％またはそれよ
り少ない、より好ましくは約10％またはそれより少ない、さらにより好ましくは
約5％またはそれより少ない、そして最も好ましくは、約アデノシンヌクレオチ
ドを除いたそれら、である。本発明の薬剤は、配列中に存在する1以上のアデノ
シンがここに例示したいような一般塩基（B）によって置換された、最も好まし
いグループの配列およびそれらのフラグメントとして含まれる。同様に、また、
上記のような、配列、そのフラグメント、またはそのセグメント内に含まれるア
デノシン（類）［A（s）］をB（s）で置換することによって設計された、B-含有
フラグメントのすべてのより短いフラグメントも含有される。限定されてはいる
が、配列およびフラグメントのリストを以下に提供する。

【００２６】 アンチセンスオリゴヌクレオチド配列フラグメントのある例は、それぞれの遺
伝子の開始コドンを標的としており、ある場合は、アデノシンを、”B”で表し
た一般または代替塩基アデノシン類似体で置換されており、アデノシンA₁および
／またはA₃レセプターと結合する能力を欠いている。事実、そのような置換ヌク
レオチドは、「スペーサー」として働く。以下に示す多数の例は、一つのそのよ
うな配列および開始コドンを含む多くのフラグメントを提供し、好ましくはヌク
レオチド数nが、約7、約10、約12、約15、約18、約21、および最大で約28、約35
、約40、約50、約60である。

【００２７】 ヒトレセプター関連アンチセンスポリヌクレオチド 5'-GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C TGCTTTTCT TT
TCTGGGCC TCTGTGGTCT GTTTTTTTCT GGCCCTGCTG GGGCGCTCTC CGCCGCCCGC CTGGCTCC
CG GBGCCCBTGB TGGGCBTGCC GTGGTTCTTG CCCTCCTTTG GCTGCCGTGC CCGCTCCCCG GCC
TCCTGGC GGGTGGCCGT TGGGCCCGTG TTCCCCTGGG GCCTGGGGCT CCCTTCTCTC GCCCTTCTT
G CTGGGCCTCT GCTGCTGCTG GTGCTGTGGC CCCCGTACA CCGAGGAGCC CATGATGGGC ATGCC
ACAGA CGACAGGCGT BCBCCGBGGB GCCCBTGBTG GGCBTGCCBC BGBCGBCBGG C GGC GCC G
TG CCG CGT CTT GGT GGC GGC GG GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC GT
T CGC GCC CGC GCG GGG CCC CTC CGG TCC CGG GTC GGG GCC CCC CGC GGC C GCC
TCG GGG CTG GGG CGC TGG TGG CCG GG CCG CGC CTC CGC CTG CCG CTT CTG GCT G
GG CCC CGG GCG CCC CCT CCC CTC TTG CTC GGG TCC CCG TG ACA GCG CGT CCT GT
G TCT CCA GCA GCA TGG CCG GGC CAG CTG GGC CCC BCB GCG CGT CCT GTG TCT CC
B GCB GCB TGG CCG GGC CBG CTG GGC CCC ACA GAG CAG TGC TGT TGT TGG GCA TC
T TGC CTT CCC AGG G BCB GBG CB TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG G
CC CTT TTC TGG TGG GGT GGT GCT GTT GTT GGG CTT TCT TCT GTT CCC BCB GBG C
BG TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG GCC CTT TTC TGG TGG GGT GGT G
CT GTT GTT GGG C TTT CTT CTG TTC CC TTT CCC CTG GGT CTT CC CTC CTG CTC T
TT TTT C ATT TGC TCT CCT ATT ACT TTC TGT GTC CAT TTT TTC ATT AAC CGA GCT
GT BTT TGC TCT CCT BTT BCT TTC TGT GTC CBT TTT TTC BTT BBC CGB GCT GT G
CC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G
GTC CTG CTC CTC CGG GCT GTG G GTC GTG GCC CTG GCT CCG GCT GGT GGG CTC C
CC TGG CCT TCG CTG GCT GGC GGC GTG C GGG TCT TGC TCT GGG CCT GGC TGT GGC
CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC TCT CTG AAT ATT GAC C
TT CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA TCT CTG BBT BTT GBC CTT CC
T CCB TGG CGG TCC TGC TTG GBT TCT CCC GB GCC TTT CCT GGT TCT CTT GTT GTT
TTT GGG GTT TGG CTT ACA GTA GAG TAG GGG ATT CCA TGG CAG GAG CCA TCT TCT
TCA TGG ACT CC TTC AAG GAG ACC TTA GGT TTC TGA GGG ACT GCT AAC ACG CCA
TCT GGA GC BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG B
CT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC
GTT GTT TTT GGG GTT TGG CTT GCC TTT CCT GGT TCT CTT BCB GTB GBG TBG GGG
BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT
TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC GCC TGT GTC TGT CCT CCT GCT T
CG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT GTG
G GTC CTC GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC G
GC GTG C CCC BGB BCG BGB CCC GGB CCG BCB GGC CGT GGT TGG GGG TCT TC GCT
GCC TCC GTT TGG GTG GC GAT CTC TGA ATA TTGA CCT TCC ATG GCG GTC CTG CTT
GGA GBT CTC TGB BTB TTGB CCT TCC BTG GCG GTC CTG CTT GGB TCT GGG GTG TCC
TGG CCT TCG TGG TTC CTC TTC CTT CGT TTG CCG TCC GCG GGG GCC CCC GGG CCT
GGC TGC GCT CCT GCC CCG CCT CTT TCC CGG GCT CTT GCG CTG GGG GGT GCT CC
CGT GTG TTT GCG CCC TC CTC CTG GTC GCG CTT GTC GTT TTG GGG CCG GCT TTG C
CC GCC TCC CGG CGC CTG GCC CGG CC TTC CTG GGC TGC GTG CGC GTT CTG TTC TT
C TTC CTG GCT CTG GGG TGT CCT GGC CTT CGT GGT TCC TCT TCC TTC GTT TGC CG
T CCG CGG GGG CCC CCG GGC CT GGC TGC GCT CCT GCC CCG CCT CTT TCC CGG GCT
CTT GCG CTG GGG GGT GCT CCC GTG TGT TTG CGC CCT CCT CCT GGT CGC GCT TGT
CGT TTT GG GGC CGG CTT TGC CCG CCT CCC GGC GCC TGG CCC GGC CTT CCT GGG
CTG CGT GCG CGT TCT GTT CTT CTT CCT GGC GCA GGA GAC AGG GCA GGG CGA TCA
GGA GCA GCG TGA GCC AAA GGA GGA CCA TCG GGA ACG CAG CTC CGG AAC GCA GGA
CAG AGG TGC C GC BGG BGB CBG GGC BGG GCG BTC BGG BGC BGC GTG BGC CBB BGG
BGG BCC BTC GGG BBC GCB GCT CCG GBB CGC BGG BCB GBG GTG CC TCT GCC CTG
TCC GCC GGC TCT TCG GTG GCT CGG CCC CGC TCC TTG TCT TGC CGC GGG TTG GTT
CCT GGG CCT GGT TCT TGC GGG CGT TTC GGT CTG CTG GCT GGT CTG GGC CCG CGG
TGC GGC GGG TGG CTT GCT GTT CTG CCT GGG CTC TCC CCT CTC CTC CTT TTC TCC
CTT CCT CTG TCT TGC CTC CTT CCT CTG GGT CCT CTT GGC CTG GGC GCT CTT CCC
CTC GGG CGG CTG CGG GCG CTC GTG CTG CCT GGT CCG CTC CCT GGG GGT GCT CCT
TCC CTT TCC CCG CTC GTG GGG TTT GCG GGG CTG GGC TGC CCT GGG GGG TCT GGG
CCT TTT GGG GTC GGC TGG CTG CTG CTT CGG GCC GCC TGG GCT TCC CTG TGC CCC
TTT CCT CTG CTG GGT CCC CCT CCC GTT CCA AGC TGC ACC GCA CAG ACC GGC GCT
ACA GGA CAG AGC CAG GCA AGC ACC CAT GGG GAT CCA GGC CCA GCT GTT CCB BGC
TGC BCC GCB CBG BCC GGC GCT BCB GGB CBG BGC CBG GCB BGC BCC CBT GGG GBT
CCB GGC CCB GCT G CTCAGTGGCC CCCAAAAGGA TGAGTAATAC ATGCGCCACG ATGATCATAT
CCTTTTTACT ATGAGGCCGT GTCTGTCGTG TCTTTCCTTT GCTCTTGGTG TGTCTTTGCT GTGCC
CTGCC TCTCTGCCCG TGTCTGTCGT GTCTTTCCTT TGCTCTTGGT GTGTCTTTGC TGTGCCCTGC
CTCTCTGCC CGTGTCTGTC GTGTCTTTCC TTTGCTCTTG GTGTGTCTTT GCTGTGCCCT GCCTCTC
TGC GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GC
TCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCG
GC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTG
TCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGG
C CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGG
GTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC
GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTC
CCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC
TTGGTTTTGG GCTTTTTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCC GCACGCCTCT TGCCACC
TCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AG
CGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAG
GC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGG
CCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG
GTCCCGCBGB GGCGGBCBGG C GCTGCCCGGC GGGGTGTGCG CTTGGCGCTC CCGTGCTCGG TTC
TCTGTCT CCCGGTCCCC CTTGCCTGGC GTCTCGGGCC TTCGTCCTCT TCCTCTTCTT CCTTCCGCT
C CGTGGGGGCT GCTTGGTGGG GGCCTGTGCCT CGGGGTCCCG GGGCTTCTGG CCCTTGCCGT TCA
TGGTGGC TAGGTGGGGC GTTCBTGGTG GCTBGGTGGG GC GGG GTG GGT BGG CCG TGT CTG
GGGGTT GGC CBT GTT GGT TGC CTCT TGG TGG TGC GCC GGG CGCG TCT TGG CTT TCT
TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT GGGCT CCT CCC GGG CGG CCT CCC C
GG GCG GGG GCT TCT TGGCG CTG GCG GGG GGG CCT CCTGCT CTG TGG CTG GGC GTT
CCT TGG TGT TCT GGG TGGTGG CGG GCG TGG TGG CCT CTG TGGGGG CCC GCG GCT GC
B GGG GTTG CCT GTC TGC TTC GTCCTT TGC GCT CCC GGG CCG CCGGG GTG GGT AGG
CCG TGT CTG GGGGTT GGC CAT GTT GGT TGC CGGG CCC GCG GCT GCA GGG G ACAGGG
GCTG TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CACATCTGTG
GATCTGTAAT ATTTGACATG TCCTCTTCAG TTTCAGCAAT GGTTTGATCT AACTGAAGCA CCGGCC
AGGB CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTTBGBTC BTCBBBBTCC C
BCBTCTGTG GBTCTGTBBT BTTTGBCBTG TCCTCTTCBG TTTCBGCBB TGGTTTGBTC TBBCTGBB
GC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC TGTTGTTGCG GCGCTCGGTT GGTGTGGCCC CTG
TGGTGCT TCGTTTCCCC CTCTTTCTCT TTGTTCGGGG GTTCTTGTGG CGGGCTGCTT GTCTCGTTC
C GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCA
GCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG
TCCGGTGGCC GCCGCGCC CTGTCGGGCG GGBBGCCTCT CTCCTCTCCC CBGBTCCGCG BCBGGCCG
CB GGCBBGBBCC BGCGCBBCCB GGGCGCGTCC GCBCBGBCTT GGBGGCGGCT GCBTGCTGCT BCC
TGCTCGGGCG GGBBGCCTCCG GTGGCCGCCG CGCGTCCGGT GGCCGCCGCG CCTCTCTCCT CTCCC
CGTGG CCCTGTCGGG CGGGTCCTGC CGTCCTGTCT CCTTTTCTTT TGCTGTCTTG TCTTCCCGTC
TCTGCTTT GTCTGTCCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGGG CTTCCCCGGC TTCGGGTG
GC CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGGGCTGCC GGG
TCCGCGC GGCGCCTGGG CCCTTGTGCT GCTTTTTGCT TGTTCCGTTC TGGCTGCTCC GGTCTGTGT
T GTGGTTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG GCCCTTTGGG GCCT
TGGCTT CTGGCTCGTC TGTCCTCCCC GTCTCCTCCC ACTGCTTCT CCCGGGGGCT TCCCCGGCTT
CGGGTGGCCG GTGTCCCGGG CTCCGGCGCG GCGGCGGCTT CGGCTGCGGG TGGGTGGCGC GGGCTG
CCGG GTCCGCGCGG CGCCTGGGCC CTTGTGCTGC TTTTTGCTTG TTCCGTTCTG GCTGCTCCGG T
CTGTGTTGT GGTTGTTTTG TTTCTTCTTG GGTGTGGGCC TTGCGGTTTT GGCTGTGGGC CCTTTGG
GGC CTTGGCTTCT GGCTCCAT CCACATGATT GCTTAGATTT GTGCTGTATC TCTCAGGATT ATCA
CTGATT ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC AAAGGGTTTC CATCTTGAGG
CAAATTTGAG GACBTCCBC BTGBTTGCTT BGBTTTGTGC TGTBTCTCTC BGGBTTBTCB CTGBTT
BCBC BTCCBBCCBG TGCCBGCCBB BBGGBTGCCC TGBGGCBBBG GGTTTCCBTC TTGBGGCBBB T
TTGBGGBGGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG
TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG BGGTG
TTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTTT CGBBGCTBGG
CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG TCGTGGCGCC TGGGGC
TCBG GGTCCGGGC TAAGATGATC CACATCACTA CCACGTTGCC CACCACAGAG GTCACCACAA TG
ACCGTGTA GGCAGCTGCC CAAAGGACAA TTTGCCAGGC TGGTTGCACG AACTGATTGG GTTCCGAG
GT GTTAGTGGAG ATGTTTGGGG AGAGGTCTGA GTCCACCGGG AGGACGTTAT CCATTTCGAA GCT
AGGCGGT AAAGCCCTAC TATCTGTACA CAACCCCCCT CTGCAGCAGA GTCCTGTCGT GGCGCCTGG
G GCTCAGGGTC CGTCCTGTCG TGGCGCCTGG GGCTCTTCTT TTGTGGGCTC TTTGGTGGCT GTGG
CTGTGG TCTCTGTGGT TGCTGCCCTG GGTCTGGGGG TGTGGCCTTG GGGCCGTCCT CTGGCTCCTC
CTCGTGGGCC CCC GGTGBCBTTG BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC C
CAGCCACTC CACTTGGGGG CGGGTGGCCA GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGA
AGG GCAGCCCGCA GGCCAGGATC AGGTCTGCTG CGGCCGGAGA TAATGGCATT CACCACGCGG CG
GCCCAGCG CACGCCGCGC ATCCGGCCCG GGTTCTGACC TGCAGCCCCC GTCTCCTTGG CATTCCTG
GG CCCCAGTCAC TCCTCTCCCT GCCCCCCTTG CTGGGGCAGG GACGGGGTG BCBTTGBGCB TGTC
GGCGCG GTCCCGTTBB GBGTGGGCCC GCCAGCCCAG CCACTCCACT TGGGGGCGGG TGGCCAGCAC
GAACAGCACC CAGAGGAAGG GGGGCGGCCC AGAAGGGCAG CCCGCAGGCC AGGATCAGGT CTGCT
GCGGC CGGAGATAAT GGCATTCACC ACGCGGCGGC CCAGCGCACG CCGCGCATCC GGCCCGGGTT
CTGACCTGCA GCCCCCGTCT CCTTGGCATT CCTGGGCCCC AGTCACTCCT CTCCCTGCCC CCCTTG
CTGG GGCAGGGACG GCCGTGTTGT CBGTGGTGCT GCCCGTTTGB GGTBTGGCGC TCCBCCBBTT C
CCTTTTCTC CTTGTTTTCC GTTTCTCTTG CCGTCTGTGG TT ATGCCGCCCT CCATCTCAGC TTTC
CAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG
ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGC
GGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC
AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCC
TGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT G
GTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGA
CTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGC
ATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTC
A ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTA
CCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG
GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGC
CTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC
TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATC
CAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC C
CATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTG
CCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT
CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGA
ACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG C
GGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCC
CGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG AT
GGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCC
CT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGC
CCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCT
T CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTC
ATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC
ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCC
TCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC
TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCT
GGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT G
GAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATC
TAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GA
CCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTT
TG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACA
AGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTG
T CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGC
TGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT
TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGG
GGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA
CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCT
GGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC T
GCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGC
AGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TG
TCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACG
GA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCT
AAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGG
T GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGG
GTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT
GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTG
AGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC
CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAG
AACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT C
TGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGG
AGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CT
AGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTT
AG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGG
GGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTG
T GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGT
CGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA
ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCAT
TTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT
AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGT
GTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG C
GACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCC
TTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GG
ACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCC
TT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCA
GGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGAT
C TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGG
TGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA
CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTG
GCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT
GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACT
GACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC A
TGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCA
ACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT AC
CTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGG
AA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCC
TTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTA
C ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCC
AGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA
TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCAC
ATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC
CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTC
CACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA C
GGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCA
GTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TG
GGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCA
GC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTG
AGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA CCCAGCCCCG AGGCTCAGAA GCGGCA
GGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC G
GCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACG
CGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GC
GCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCG
GC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CAC
TGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAG
C CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGG
TCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA
CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGA
ACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGCTACAT
GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAA
GATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC C
TCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGT
TAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AG
TGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCT
TA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGC
AGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAG
G CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCA
TTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGGAGCTAC
CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA TGATC
TATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCTTTTG
TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTTTA CTGTGAAACA GTGTGA
ACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA A
AATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGG
TGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TT
CAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA
CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTC
CGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC C
GACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGT
CCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TA
GGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCG
CT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CAC
GGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGT
G GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCT
GCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG
CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGA
GCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG
GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAG
CTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT T
TCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGG
CCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TC
CATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCT
GT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TAT
GGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGA
C TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTG
GGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC
CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGC
TACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT
AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTT
TTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC T
GCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGC
AAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG GAATTCCCA
G ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGG
TTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT
TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGG
AGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTTTTT
TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAA
GCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG C
TTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAA
ATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TC
TGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGA
GT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAG
AGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTAC
T GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAG
CCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA
TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAG
TGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC
AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTG
ATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT C
CTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGC
TGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TC
TGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTG
TG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGC
TGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTT
G CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTG
TCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC
ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGC
CCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA
AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTC
AGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT G
GAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAA
AAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GT
CTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGT
TC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATC
ACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAG
C TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGC
TGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG
CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCA
TCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG
CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC CTGCTGAATT TTATTTTGGA CTGTAC
ATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT G
TTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCAC
CTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CT
AGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTG
AG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTC
TTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGC
C AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAG
GTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT
GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAA
GAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT
CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAAT
CAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT C
TGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCT
TTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TG
AAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACA
TC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCA
TTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTT
T CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAA
TTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT
ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAAC
AACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG
ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGG
CTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC C
AGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGA
CGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GG
AGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTAC
AT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGT
CAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACAT
T GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCT
ACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG
CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCAC
AGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT
GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATT
TGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC C
TGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACT
TAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TT
CTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTT
AA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GAT
GAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGC
C TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTAT
CCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA
TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCT
CCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT
CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTC
CTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA G
GCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGA
GAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GG
GACTTAAA CTGCTGAATT C CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAA
ACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC C
AGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCG
GAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CG
CACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGC
CT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCG
TGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGG
T GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTT
TGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC
CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGC
ACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG
AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGA
AAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC C
AAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTA
ACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TG
CTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACAC
TG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACC
AGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCC
C CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATG
AGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC
AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAA
GGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG
AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGA
ATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG A
GGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAA
GCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA AC
CTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAA
GG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCT
AGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAA
C CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATG
GAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC
TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTC
TGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC
CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAA
AACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA A
AAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACT
CTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CT
GAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGT
GA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATG
TAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA
ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGT
CTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA
CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCG
CCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT C
CTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTC
AAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TG
CTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGA
GC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCA
TCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGG
T CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCC
TCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC
TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTC
CTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA
ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACC
ATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G
ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGC
TGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG
TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCT
TGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA G
CCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGG
ACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GT
GCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAG
GT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCA
GGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGC
C CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCA
TGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG
ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCG
GTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA
CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTG
CGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG C
CCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACA
AGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AG
TCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATC
AC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCA
CGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCT
T AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAG
AGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA
GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGG
GCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT
ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAG
GCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG G
GCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCT
GCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AG
GAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTG
TA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAG
GACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGG
A TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCT
GGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA
GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCAT
CTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG
CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTG
GGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG G
GTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCT
GTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TT
GCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGC
CA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCG
AGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGG
G GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTG
CTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT
AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTG
AAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT
TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGAT
GGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC C
ATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAA
GGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GT
GACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCA
TG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTC
TCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACC
T TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGC
CATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT
CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCA
AGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC
TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAG
CGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA T
CAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGT
CCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CT
CCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCT
TC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCC
TGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAAC
C CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCA
TTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC
CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGT
CCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA
GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGG
AGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC C
CCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGA
GAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TC
TGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCT
GA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA
CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGG
GTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC C
GGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTC
GGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CA
ACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCA
TC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTG
GTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGT
G TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTG
GGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA
CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTG
AGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG
CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAG
CTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA T
TGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCC
AGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TT
CAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTA
TC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCT
GCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAA
A CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCC
TCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA
AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTT
GAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA
AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGG
AAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA A
AAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGG
CAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGT
TATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT
TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTG
CCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG C
TCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTG
CCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GG
AGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACG
TG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTG
TCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTG
G GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAG
CTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA
TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTG
GCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA
CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCC
ATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG T
GATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTC
GAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TG
CCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAA
AT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCC
ATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTT
C TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGG
CCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG
GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTT
CCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA
TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAA
CAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT G
TGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTT
GAC TGTACTAAAA ATG GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTC
T CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGT
TTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC
ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCT
ATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT
TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGA
GGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG A
CATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAG
TCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AA
CTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAA
GA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGT
AAACACC AGAACGCCAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTA
A GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGC
CTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG
TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTC
AGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA
ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTC
TGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT G
CCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCT
CAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CT
TTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGA
AT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGT
TTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGC
T CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCT
TGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT
TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTA
TCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA
CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGA
GGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG G
GTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCAC
TGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TT
GCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCT
GT CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCA
ACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTG
T CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGC
CTGGGC ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC
GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAG
GTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGCS
CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAA
GCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA
ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAG
TGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA G
TCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGAT
TCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CT
CACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCT
GA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCT
GAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGT
G CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCT
GCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG
CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGT
CCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC
ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGC
CCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA A
AAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGATTC
AGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TG
GAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAA
AA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGT
CTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGT
T CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGG
GGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC
TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAG
AAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT
GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGA
TCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC T
GCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTG
GGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TT
CATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGT
CA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTA
CCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCG
T CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTG
TCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA
AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAG
CTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA
TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGG
AGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT A
TCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATC
CTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AA
GGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAG
CA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCC
CCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCC
A CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTC
CACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG
TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGG
GTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT
TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAAC
AGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C AAATGATAGA CCGTCAATAA
TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCA
GCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG
GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCC
CAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC A
AGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAA
AAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CA
GGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAG
GT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTG
CTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAAC
T CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAA
CTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG
GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACA
CACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG
ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCC
CCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC T
GTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGT
CAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GG
AGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAAT
AC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTG
CTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCA
T CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCA
GTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC
CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGG
TTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG
GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGG
CCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC A
CCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTG
GGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TT
GCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTAT
AC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCA
TTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCT
T TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTC
CCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT
GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTG
GAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC
AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAG
AGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA G
ATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAA
TGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GA
ACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATA
GG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTC
CACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTG
C ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTC
AGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA
TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGG
GGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC
CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATT
CAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA A
AGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAA
GTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GC
AATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATC
CC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTG
AAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTA
G AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAG
CACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA
CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGT
TCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC
CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCC
CCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG G
GGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAA
AAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CA
GCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCC
GT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCC
TTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTG
T GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAA
AAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC
AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCC
CATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT
CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTG
GTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA G
TGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTT
TAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG AC
ACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACC
CC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CAC
GATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGA
C TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACAC
GGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG
AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTT
GGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT
AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATG
CAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT C
TCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTC
TTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GA
GCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGC
TG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGC
TGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTG
C CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGT
GGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA
CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGC
TCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC
ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATC
TGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA C
CTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCA
GAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GC
CCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACG
AG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AAC
CCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTG
T GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGAC
CTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA
CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCA
GGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG
GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGC
ACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG C
CTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGT
GTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GG
TGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTT
GA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GAC
CAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCA
C ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGA
GCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA
AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAG
GTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC GCCCTTCAAA GATGAGCTGT TC
CCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGA
CA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGT
GGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAG
A GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTC
A ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGA
GGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC
AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGC
CAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC
ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTG
GTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT C
TGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGG
TTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CC
CTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAG
CC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCG
CAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCA
T GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAA
ACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA
GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCC
GGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC
TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAG
CCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG A
GGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCG
CCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CA
GGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGC
CG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGA
GGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTT
C CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC
CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGA
ATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG
ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACA
GCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT G
CTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTG
TTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GC
AATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAA
GG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAG
GATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACAT
A TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCC
ATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC
TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGG
TTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA
TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTAC
GTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG A
GGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTG
TCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CA
ACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGC
AG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGC
CGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGA
T TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAA
GGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT
TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGC
TAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT
AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGG
AGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG G
CTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAA
CCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CT
GGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGA
GC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAG
AACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAA
T TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACC
ACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC
ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAA
GAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC
TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGT
CTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA A
AGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAA
CAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA AAA
TGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCT
C ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGAC
CAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG
CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCA
AGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT
CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTT
TCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC A
AACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAAC
CCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TC
ATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCT
GA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCA
GAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATA
C CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTT
TCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA
GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGC
CTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT
GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCA
ACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG C
CCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCC
TGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CC
AGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCA
GC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCT
TTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAG
C ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCC
CAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC
TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTG
CACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC
CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACT
GTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC A
GCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGG
GAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CT
GTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGA
GT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CAC
CACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACAC
C CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGA
TGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA
ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATG
TTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC
AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACAT
TTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA G
AGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGG
TCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CT
CAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGAT
GA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGA
GAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATA
G ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGT
TGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT
TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCT
TGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC
CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCAC
ATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT C
AGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAG
CAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CA
CCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAA
AG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTC
CCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTG
C CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTT
CTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT
CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGG
AGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC
ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGC
TCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA T
GATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACC
TTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GA
GTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGT
TG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGA
AGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTC
A TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAG
GTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG
GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAA
TGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC
CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTA
ACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT G
GCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGA
AGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CC
ATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATT
AA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTT
GATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGA
G ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAA
CATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA
CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTT
GTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC
AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAAC
GGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC C
CCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTG
CCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GA
TCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGG
AG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTG
ATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGC
G TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCAT
GCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG
CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGC
CCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG
AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTC
ATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC T
CTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAG
CAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GG
AGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCA
TG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGG
AGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCT
T TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGT
CTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA
TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTG
CCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA
CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAAC
TGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT C
TATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTG
ATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AA
GAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAG
GG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGG
CACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAG
C AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC CTGCAG
AAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC C
TTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTT
CAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CA
AATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGT
TC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGC
ACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCC
T TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGT
GAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG
CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCT
ACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG
AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGG
GAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT T
CTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGAC
GGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CT
TCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGC
GC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCA
CTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGC
C AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTC
CATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC
CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGA
ATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG
ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACA
GCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT G
CTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTG
TTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GC
AATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAA
GG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAG
GATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACA
T ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGC
CATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC
TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGG
TTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA
TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTAC
GTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG A
GGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGG
TT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AAC
CCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTC
A GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAG
GCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT
CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTT
GGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA
AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAG
ATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG T
CAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGG
CTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GG
TAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTC
TT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATC
CAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTC
T TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGA
CCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT
TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTT
TCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG
CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCA
CCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG T
CATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCT
GCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GA
TGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGC
TA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGC
ATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCC
T ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTC
TTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA
CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGG
CAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA
GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTG
TTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG C
TGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTA
TTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AG
GAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAG
GA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCT
TTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGT
C CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGT
GCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA A
TGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCT
CTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AG
AGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTG
CT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAG
CTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCT
G CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCG
TGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG
ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAG
CTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC
CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCAT
CTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC A
CCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCC
AGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TG
CCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGAC
GA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAA
CCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGT
G TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGA
CCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA
ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T ATGTTCTCTC CCT
GGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCG
A CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCC
CAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG
GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGC
AGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG
CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCA
TTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT G
GCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTG
GTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TA
CAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTT
CA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGA
TGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGA
G GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATC
AGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC
GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTA
CGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG
GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCG
TGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG G
GCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCG
CCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC
CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCA
GGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG G
GAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTGT
TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGG
GACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA G
GTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCAC
AGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCT
TCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CA
GAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACT
CC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAG
GCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGC
C ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGC
TGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT
CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAG
GGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG
CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTG
AGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA G
CGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGG
CAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GT
AAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGAT
AA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAG
CCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAAT
C TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGC
AGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG
AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGC
CGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT
CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGT
GCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG G
GAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCC
TTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAAC
GC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAG
GAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGA
G ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCA
CAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT
GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTG
TGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT
GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTG
AAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC C
AGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCAC
ATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AG
CCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAA
GC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAA
GGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAAC
A TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCT
ACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG
AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAG
TGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC
CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAG
GCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC A
GCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGG
GAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AA
AAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAAT
AT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGG
GCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGC
T AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCT
GGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG
GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAG
AACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC
CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGA
GAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC T
AGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTG
AAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CA
CCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAA
CC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAA
AAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCT
C TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGA
GTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA
AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTA
AACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA A
AATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGC
CTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AG
ACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGT
GG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGG
CAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTC
T CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAAT
TTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC
AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAA
ACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT
TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGT
CTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT G
CAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACA
TAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GC
TTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGA
AA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGC
GCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATG
T GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTT
CAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG
CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGAC
CCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA
CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTC
CAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG C
CTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCA
AGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC AT
CCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTT
CC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCC
TGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTC
C CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCA
CTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC
AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCA
GGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC
CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCT
GAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC C
ACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGAC
ACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GT
GATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGG
GA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATA
TGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACC
C AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGAC
ATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA
GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGG
GGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT
CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTG
ATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC T
GAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGA
TAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GG
GTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGT
TT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGC
CTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGAT
C CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTC
ACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT
CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGA
AGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA
CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGC
AAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC T
TCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTG
TGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GC
TTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAA
GT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCA
GGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAG
C ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTG
GCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA
TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGA
CCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT
GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAAT
GTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA A
GAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAAC
TCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AA
AGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATG
AG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACT
AATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAAC
C CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAG
TAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT
GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATA
GAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG
CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAA
TTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG G
TTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTT
GAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AG
AACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTG
CA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGG
TTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAA
C AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTA
ACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC
CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTC
TGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT
GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGG
GGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC C
TGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCG
GCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CC
ATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATC
AG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCT
GCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCA
G AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTAT
TCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC
TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTAC
AGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG
GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTC
CATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA G
GGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTG
CTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG AT
GTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAG
GA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGC
TGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTG
A CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGA
ACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT
CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCC
TGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA
AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAG
AGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT G
GGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGAC
AGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC CTGC
AGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC
CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCCAC TTTCT
TTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG
CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCT
GTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC T
GCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGC
CCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TG
GTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGAC
CG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCT
CTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCAT
G AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCT
GGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT
TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAG
ACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC
CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGA
GCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC C
CACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGT
GCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CC
TCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAAC
GC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAG
GAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGA
G ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCA
CAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT
GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTG
TGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT
GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTG
AAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC C
AGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCA
CAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GA
GCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAA
GC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAA
GGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAAC
A TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCT
ACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG
AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGT
GGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG A
ACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCT
TCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CT
AGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTT
TT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCC
TTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTC
A AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTC
AGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG
TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCT
GGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG
GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCAC
TCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC A
TCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCG
TCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CA
GACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTC
TT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTG
TTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGAT
G CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCT
CACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG
TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTC
CTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA
GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCT
GCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC G
GCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGG
CCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AG
TCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAG
AA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTG
GGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGAC
A GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAG
TGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG
CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCT
TATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG
AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCC
AGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT T
CTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGG
GTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CT
GTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA
ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGC
CTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC
AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGG
TGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG C
AGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGG
CTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CG
CGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCAT
CG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCA
AGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGA
C CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTC
ATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC
ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGAT
CCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC
TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGG
ACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT C
AACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGA
GTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CG
GACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGC
AA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T ATGTTCTCTC C
CTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGC
CGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CC
CCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGC
TG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTG
GCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGG
G CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGC
CATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT
GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCT
TGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG
TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTG
TTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA C
GATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAG
GAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GA
TCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCA
TC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTG
TACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAA
G GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTC
CGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG
GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCC
CGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTG
C CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGG
CAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG
GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTG
T TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTG
GGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA
GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGC
ACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCT
CTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT
CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAA
CTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC C
AGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAG
GCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TT
GCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTC
CT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGA
AGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCA
G CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCC
TGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA
GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGT
GGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC
GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATG
ATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT C
AGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAA
ATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CC
GCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGG
CG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCC
GCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACA
T CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGG
GTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG
GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTC
CCTTC CTTCCGGAGG GAGG GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAA
GAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG C
ACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGA
TGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TT
TGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTT
TC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACT
CTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTT
G CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGG
GCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA
GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTG
CCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC
TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATAT
AGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG A
TGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTA
CAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA AC
ATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCT
GG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGA
TGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCA
T GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCT
CTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA
GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACT
GACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA
CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAAT
GCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT T
AATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAG
AAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AA
GTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTT
AG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AAT
ATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC GCCACCATGG
AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTG
AGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT C
AGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAAC
TAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT AC
TATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTAT
GA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTG
ATCTCCC TATCAATGTA TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCG
T ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTC
TGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT
CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CCTGA
AGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA
ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATT
TCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG A
AGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACA
GTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG AA
GAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGA
TT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGA
GCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGA
T GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAAC
ACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT GAATTCGGGA
AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGAT
GGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC
CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGC
TCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA C
AACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGT
ACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TG
TATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCAT
TG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTG
GCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACC
T CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGG
ATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT
GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCT
CAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT
ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACA
GAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA A
ACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTG
AAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC AT
GGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGT
GA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTC
TGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACA
A CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACT
CCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC
TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGT
TTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT
TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGG
ATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT G
GTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTT
TTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TG
TCATTTGG TGCCAGTATC CCGAATTC AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA
ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTG
ACTTA GGGGTTAGAT TTTATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA
CAAGTTACTT AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTA
CTTT ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA T
GTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT TCTAAGT
TGT AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG TGCTAGACCT AT
GCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGT
GG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAA
CCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG AAAACATTTC CTTCTGCTTT TTGGTTTTA
A GCCTATATTT GAAGCCTTAG ATCTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG
GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAGCAA
GGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA CTGTCCCTGT C
TTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA TCTTTGCAAA TGACAAG
CCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT TAATATCAGA TCCTGGAAGA AG
GTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA GTAAAGGAAT CCTGGAGAAA GCCCCTGC
TG TGTATTTAAA GGAGAAAGGG AGATCATGTT GGGAAATTAT AATATTAAAA GTAAACAAAA GCT
AGGAAGT AAAATAAAAT AAATTATATG GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTC
C TGTGTTCTGA GCCAGATTAG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTC
GCTGGT CAGACAGCGG ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA
GCAGGAAATT AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TTGCT
AGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA
TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT TAACCT
CACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT TATAGGATTA T
TGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT ATGTTTGGTA TTCAGTA
ATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT TTTCTAAGTT GTAAACTAAA TA
GTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT TGTGCTAGAC CTATGCCTCT CTCTCACC
AG ATTCCAGGTG TATATGTGGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCC
CAGTTGG GCACCATCCT GAATATTATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTT
A ACCAGATATG ATACAGAAAA CATTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG CCTT
AGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT
ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGG
CCCAA ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA
CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAA
GTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA TTTGCTCTGG C
ATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TTTCTTC
CCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC CATGGATGTA GATCTTATCC CC
ACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGGACT
TT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACA
TGTCTGG GCATTGCTTT CCTCTCACTA TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATG
A ATCTGTTCCT TGGCCAGACT ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGAT
TCATTG CATTCTCTCA AGTCATTCTC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA
CATGTCTCAT TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TTATT
ATTGC CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA
CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT TTTGTT
ATCA CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT GTTCCAGGAA G
CCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA CATATGTTTT TCACTCT
GTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG AGAAACCTTA TATTTCATCC AG
TCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT CACATAATAA ATATTTAATG TAACAATG
GT TGAACATGGC AGACAGTGTT TCTACCTCAA AAGAGATTGC AGTCCTCATT TACAGATACT GAA
TTGAAAT TAACAGAAGT AGAGTGAGTC AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTTTAA
A TCTCCTGCAT ATGTGTCCTG TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAAT
TTCTCC TTCCCCTAGA AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG
ATTGTCAGAA TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TCTCT
CTACA TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC
TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT CTTTGA
AGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC AAGTTTGAAT A
TTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTG
AAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT GT
GAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA TTCCAAGGGT TAGGACACCA GAGTGGGA
TT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCC
AGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATG
G TGAAACCCCA TCTCTGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACC
TGTAGT CCCAGGTACT CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA
GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAAT
AAATA AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACTTG
TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC TATCTT
TTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACATTTCAA A
GAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTTGCT CTGCATAATC CATATGG
CAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT CTGGGTACAT TTCCTTATGT CC
TCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT CATTTTTATC ACTCCTACTG CCAACAAA
TA GCATAGCATG CTTAGGCACA TGTGGCTTAA TTAGCAAATG TTGAATAAAC AAATTAATGA TTT
TGAATAG TGACCAATAG GTCTCTTTTA TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCA
A CCTCCATATG TAAATTCCAA ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAG
TAGGTT CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT
CCTTTCAAAA TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTG
ATTCT TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT
TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG TCCCTG
ACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTAA T
TTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA CACTAGAACT GGGAAGT
TTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT AAAATTCCCA AGAAAGACTG TT
TATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT CTGAAAGGAA TTCTGGCTTT CAAGTGTT
CC ATGTATGGAC TCATCAGGGA GGTCCGAGAG GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGG
GAAAGGA TTTATCAATA CACAAGACAG GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTT
A TGAGCCAAAA AGTGAGTTAA TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCT
TTTCTC TATTCATTCT CTCTCTCTTC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTCAGA
CTGGCTGCTC CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCC
ATGGT TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC
TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC TACTGT
ACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA ATAAAAGGTG A
GTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CTTCTGAGCC TGAGCAG
TTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG AG
ACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA GCCTTGACTT GTTAAATGGT GATAGTAA
TA CCTGCTTGCA CTATGAAATT TTTATGAAGA TTAATGTGGT AATATTTGTG AAATGACTTT GTA
AACTGTT AAGCACTACC CAAGCATAAC AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTG
C TCCTGGGGGA ACACTTATAT TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGAT
ATAAAG AGCTTGAGGA GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG
CTGTGTGCCT GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACT
GCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG
TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT TTAAAA
AAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT TGAGACTGAA G
TGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA ATATTTGGTC TAGATTC
CAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT GTCTCATTTC TTGAGATTCT GA
TTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT TTCATAGGTC TTTCACATAA TGGTAATG
GG TAGCCAATAT TGAGAATCAC TTGTCTAGGT GATCTTTAAA TGATTTCTGG ATGTAATATT CTG
AGGCTCT ATAATTTGAG ACTAATCACA AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACA
A AATAATAGAA TTGGAAGGCA ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAA
GAAATG ATGATTGATT GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC
CTTAATTATA TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTC
CCCTC TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC
AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT GGATGC
CACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA AACTCTGAAC C
TCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT CCACTACAGC TCCGCGT
GAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA TTCTGTTTGC TGTGGACACA GG
ATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT TGAAGATTAA GAGAACCAGG AAAGGCTT
CA GACTTCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA ATA
TTTGCAA CATTAGTTTT TTTCCAGCAT CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCAATA
T ACATAGAAAC GTCTGTGCTC AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTA
AGTGGC ATGTAATAGT AAGTGCTCAA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATTCAT
TTATTAGCAT TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAAT
GCTTC TGAGTATTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA
GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC ATAGGA
GGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG AACTTTCAGT T
CTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATTCCT
CTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT GTCTTGTATC TTTATACAGC AC
CTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA ATAACCAAAA CCTTCGGCTC TGAAAACA
GT CCAGGACTGA ATAAGATCTT GGGCAAAAGA ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATT
TTATGTC TTCATCATAG TCATTGGAGG CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC
TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG CCTTA
GATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT
ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC AGTCCCTCAG AAACCT
AAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA GAATGTGACT CTTACATGTA A
TGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT CCACAATGGC AGCCTTTCAG AAGAGAC
AAA TTCAAGTTTG AATATTGTGA ATGCCAAATT TGAAGACAGT GGAGAATACA AATGTCAGCA CC
AACAAGTT AATGAGAGTG AACCTGTGTA CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCT
CT GCTGAGGTGG TGATGGAGGG CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GAT
GTGTACA AGGTGATCTA TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATC
T CCATTACAAA TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCT
GGACTA TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA
ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC AACTC
AGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT TCTGAACCCA
CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT TTGCAACATT AGTTTT
TTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG CAATATACAT AGAAACGTCT G
TGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG AAACTGGTTA AGTGGCATGT AATAGTA
AGT GCTCAATTAA CATTGGTTGA ATAAATGAGA GAATGAATAG ATTCATTTAT TAGCATTTGT AA
AAGAGATG TTCAATTTCA ATAAAATAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAA
AA AAAAAAAAAA AAAAAAAA TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATG
AAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG
CCTGCATTTG AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCC
TCAT CCCCACCACT GCATACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA C
ACAAATTCT GACTGCTATG ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG ATATTTC
ACA CATTGAGGGA GACATTTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG GAGCCATATT TT
TTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAA
GC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AAC
CTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTT
A TGGCTTCCTT TTCCACTGAA ATTGTAGTGA TGATGCTGTT TCTCACCATT CTGGGACTTG GTAG
TGCTGT GTCACTCACA ATCTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG
TGTTTATGAA GAATTAAACA TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGT
CTCCT CCCATTGATT TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA
AGGCCAAGGT CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT A
AGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC AAGTGGG
GAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC TTCTCAACTC CT
ACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCAGGAG
TC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC TTCTCAATTT TTCTATTCAT CAC
AAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAA
A GAGAATCATC AATGTCATGA GGTAACCCAT TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGA
AATCCA CCAAGTCTCA ATATAATAAT ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA
CACAGAAAGT AATAGGAGAG CAAATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTA
TTATT TTTTTCTACC CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA
AACTTTATTG ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTT
GCTG TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG A
AATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT GTGTATG
TAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA CATGCTTTTA TA
AATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA AGCTGTGGGA TGCTTCTC
TG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA GCCATTCCTT CATTGTATTC TGT
GCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT TCAGATACAT TTCTATGTTA AAAGGATTG
T GAGATGCATA GGTAAATGTG TTTATTTTCA GTTTTACTTG TCAACATAGA TGAATGAGAA AGAA
CTTGAA AGTAACACTG GATTAAGAAT AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC
TAATCACTTG GATAGTGTTC AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCT
TGGTG ATTACAATGA AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC
TGTCTGTCGA GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTC
ACAG TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT G
AAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA GTTCCTG
GGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA AGAATATTGA GT
TGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT TAAAAAACAT GGTAGATA
AA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG CATTTCCTCA TAAAGACTTT AAA
TTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT CATAACTTTA TCTTTACTTA GATGTAAAG
A ACAATTACTG ATGTTCAACA TGACTACATA CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCC
ATGCAT TAGGTAGTGC TTGTATCAAT TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG
GATCATTTCT CAGGACAGTC TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAA
AATGA TACAATCTCG GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC
ACAAATTCTG ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTC
ACAC ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT G
TGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC AGATCTA
ACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA TATATGTGAG CA
TATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC AATTAACGGT GGGTTAAA
CA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA TACAAGTTAA ATGACTTGCC TAA
GGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC AGAATCCAAC TCCAGGAACA TACTTCTAG
C ACTATTCATC AATAAAGTTA TATGATAAAT ACATACAACT TTATCTGTCA ACTAAAAATA ACAA
CAGAGG CTGGGCATGG TGGCTCACAC CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC
ACCTGAGGTC AGGAGTTTGA GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATA
AAAAA TTAGCTGAGT GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG
CTTGTTTGAA CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGG
CAAT AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG A
AAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC CTTCTAT
GCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT TCTATCTGGA AA
AATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT AATTGACATA TATAAATT
GC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA GACACACATG AAAACATCAC CAC
ATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT CCCTGTGTAT CTTTGTAACT CTTTCTTCC
T CCCTCCACTC CTTGTCCTCT CGTTCCCAAG AAAACATTGA TCTGCTTCCT GTGAATATAA ATTA
ACTTAC ATTTTTTAGA GCTTTATATA AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG
TTATTTTGAG ATTCTTCAAG TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAAT
TCTAG ACTATGTCAC ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG
ACTCTCCTTG AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACAC
AGCT TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA T
TTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT GTACNTT
TTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGACA CG
TGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG ATTGCAGTAG AATGAGAG
TG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT TACTACNCCA AGAGTACCCC CTG
CATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA AATGAAGAAT TTCATGCTCC ATCCAGGAC
C TAATGAATAA GAATCTGCAT TTTAGCAAGA CCCTCATATG ATTCATATAC ACTTTTTTTT TTTT
TTTTTA GATGGAGTCT CACTCTTGTC GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCACTGC
AACCTCTGCC TCCCGGGTTC AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGG
TGCAT GCCACAGTGG CTGGCTAATT TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC
AGGCTGGTCT TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTA
CAGA CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG A
AAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT ACCCCAA
ATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC TCATTGTGGC TT
TTTTTTCC TCCTTTTTGA ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT TATATCTGAA AGGAGAAA
TG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT CCTTGAAAAG ATAAGAAGAA CAG
AGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC CTATATTACT TGTGAATGTG GATATATGA
T TTTGTTTCAA TCTATTTTGT GTCCTAAGGC TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAA
CATAAA TTGTACCATT TAACATACAT GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGTGTCC
TACACCGGCA TTGTCCTTGT AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAG
GAGAA TATTTGAGGA AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA
ATATATGCTT CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCA
ATGT GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA G
TGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGC
CAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CT
ATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTG
TA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC TAATGTAAGT AAGAAGCCCT CTT
CTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC TATTACACAG TATAGTGGTT CTGTAAGTT
C ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAA
GTTATC TACTGCAAGT GACGATCTCT GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT
GTGTGTGTGT GTATGTGTCA CTTTAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGAT
GCTAT AAGAAAATAA ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT
GTTCAATAGG AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCA
CTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA A
TCTTGAATG ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC TGAAACA
TTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC ACATTTAAAT CA
CATTTTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA GGGTTGGGAT AATAGGAC
TG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA TGGATGTACA GAAGGCTTGT GAG
GAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA GAACTAGCCG CCTATTCCTG TTTCTGTTT
T ATTCCTTTGT TTCTTGACTT TTCCTTTCCA ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TTCT
GATTCA TGACTACCAA ATGTTTTCAC TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA
GACCTTGTGC TCATGTACTT GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTT
TCCTG AGGCATTCAA GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC
GCCTGTAATC TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACC
AGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA C
TAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCGTGGT
GGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAGA GA
TGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACTTCCC
AG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG GATTTGGAGA CCAGCCTGGC CAA
CATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAA
T TTCAGCTACT TAGGAGGCTG AGGCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGA
GCCAAG ATCGTGGCCA CTGCACTCCA GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA
AAGAAATTTA AAAAATCACT CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAAT
AACCT CACCAACTTG TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT
TGGTTTTCTG GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACA
AAAG TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA T
GAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT ATTCAGC
TAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT AAGAATCACG TG
TCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT GTTAAGGGGC TACTGGAA
AA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT TTATTCGCCT GATAAGAATA TTT
TGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT CTATTTGTAG ATATGATAGA CTCCTATTT
T TCTTGTTTTA TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTT
AACTGT TTGATTATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT
TGACAGTTTG ATAATATTTG GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGT
TGGGC ATGATTTGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT
TACACTATAT ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACA
TGAA GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT T
TGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG TAAATAG
GTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG TGAAACATTT GT
GAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTTA
TA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT AACAAATTAA AGAATAAAGT TAG
ACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG TCTAAGATGA AAGGAGAACA CTGGTTATG
T TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGG
CCGAGG TGGGCAGATC ACGAAGTCAG TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC
TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACT
TGGGA GGATGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC
ACCAGTGCAC TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAA
GATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT T
TTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACA
TGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA AATCATTATT AA
ATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACA
TG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATA
AACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAA
T AAGTATCCAT CAGAGACAGT ATCTCTAGGC TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAAC
TCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG
CAAATTCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGA
AAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG
CAAGCTAAGA AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATA
AGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT T
ACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT AGATTGT
GAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT ATTTAATTGT AG
GGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT CCAAATTTGA CAGCAGAA
TA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT AGG
TATTAAT CACATCACTT CCATGGCATG GATGTTCACA TACAGACTCT TAACCCTGGT TTACCAGGA
C CTCTAGGAGT GGATCCAATC TATATCTTTA CAGTTGTATA GTATATGATA TCTCTTTTAT TTCA
CTCAAT TTATATTTTC ATCATTGACT ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT
CTCAAGATCA TTCTGAGAGT TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGA
CACAG AGCACAATGC TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA
ACTTCAATGT CATCTTCTCC ATGAAGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTT
GCTC CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC T
CCTTATGTA TTCTCAATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT TCTTATC
TGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCAA TA
AAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC AGCTCTTTAT CAAACAGA
AC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA TAA
ACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC ACCAGCCATC TTTTGTCAAT AATTGATGG
A ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATTTGACC AGTCAGTCCT CACTCTTATT TACT
TGCTAT GTAAACTTGA GAAAGCTTTT TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA
AATTTGGAAC AAAAGATTCC TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTA
GGATT TTTGGTAATC ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG
GTGGACATAT TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCT
CACG CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA G
ACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGG
TGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AG
GCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCG
TC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAA
TATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG GGTTTTTTTC CTAAAAATTG TCTTAGAAA
T AAAATTTCCC CTTTGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTG
AAACCC CGTCTCTACT AAAAATACTA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC
CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC GCCACGTGCT GCTGGGTCTC AGTCCTC
CAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AATGTTGCGC TTGTACGTGT TGGTAATGGG AG
TTTCTGCC TTCACCCTTC AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGA
GG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCC
TACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGG
A CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGC
CTTGCA GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC
CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA AATTT
TAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG TGACAAAACT
GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTTTGG ATAAAGACAA TGAGAAATTT CTAAGT
GTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA AGATGCTGGC TATTACCGCT G
TGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT CACTAGGAGT ATTGAGCTAC GCATCAA
GAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTCCCCCCTC AAGACCATAT CAGCTTCTCT GG
GGTCAAGA CTGACAATCC CGTGTAAGGT GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGT
GG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCA
CGCCAGG AATATTCAGA AAATAATGAG AACTACATTG AAGTGCCATT GATTTTTGAT CCTGTCACA
A GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACG
CACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTTCACTGGC
CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC AGATG
GTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA TAAATGGAAT
GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA GCCGGAGCCG ACTCGGAGCG CGCGGCGC
GG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGA
GCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCG
C CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCA
GGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG
GCCTTCTCCA AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTC
TTCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG
AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT ATAAAG
ATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA AAGAGAAACT T
TGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG TAAGAAATTC ATCTTAC
TGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC CTAACTTATG TTATAATGCA CA
AGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG GAGGACTTGT GTGCCCTTAT ATGGAGTT
TT TTAAAAATGA AAATAATGAG TTACCTAAAT TACAGTGGTA TAAGGATTGC AAACCTCTAC TTC
TTGACAA TATACACTTT AGTGGAGTCA AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATA
G AGGGAACTAT ACTTGTCATG CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTA
ATAGAA TTTATTACTC TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG
ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGA
CATTG CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT
ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA TATCGG
AAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGTTTTGCC AAGAATACAC ATGGTATAGA T
GCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA TGATTGGTAT ATGTGTC
ACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATCTATAAAA TCTTCAAGAT TGACATTGTG CT
TTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA AAGCTTCAGA TGGAAAGACC TATGACGC
AT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTCTACCTC TGACTGTGAT ATTTTTGTGT TTA
AAGTCTT GCCTGAGGTC TTGGAAAAAC AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACT
A CGTTGGGGAA GACATTGTTG AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATC
ATTTTA GTCAGAGAAA CATCAGGCTT CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG
TATAATGCTC TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTA
TGAGA AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG
ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA TGCCAG
TCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG AGAAACTGCA A
AGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT CTTTAGGTGC CTCCTGT
CTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA GAGTTCATGG AATGTAACTA TA
TCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3'(配列番号3002) ヒト酵素関連アンチセンスポリヌクレオチド 5'-CTT GCT CCT GGG GGC CTC CTG GTC CCT CTG GCT G TT CCC GGC CCT GGB CTG
GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB
GGC TCB GCB TCC TGG CCB CGG BBT TCC GGT GTG CGG GGC CTG GTG CC CCT GGG C
CT CGG GTG CTG CCT GT GCG CTG CCT TCT TCT CCT GG GTC CTC GCC GGG GCC CTT
GCT GCC CTG GCT GT GCC CTG GGG GTC TGG GTT CGG CTG T CCC CBG CBG GBC CB
G TCC CBT CCB CBG CGT GTG BTG BGT BGC CBT TCT CCT GCB GCC GBG GGG CGC GG
G CGB GCB TCG C TTT GGG CTT TTC TCC TTT GGT T TGB GCG CCB GGB CCG CGC BC
B GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG GGGCTCCCGC CGCGBGB
GGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC BTTCGCCBCG CBGTGCGCGG CC
GBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCCT CCGCGCBGCT GCBGGGBC
BC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGT
GCCCCCC BGCBGCBBGG CCGGCBGGBC BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBT
G GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGCTGG TGGGGCTGGG GCTCCGGGG TCTCT
GCCCC TCCGTGCCGC GTGGGGCCGC GCTCGCCGGC CCCCCCCTGC CGGGTGGGCT CCCGCCGCGC
GCCGGCCTGC CGGCCCCTCG TGGGTCCTGC TGGCCGGGTC CGGGTCCCGG GGGTGGGGCG CGBGTC
GGCG GCCGBGGGTC CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB T
GTBGGGGCG GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGG
TBG GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG CBTCTTTCCT GGTGGGGCCT GCTCTCCCGG CC
TCCGTGTG TTGCTGGGTG TTTTCCCGTC TCTGGTCTGC CTTCGGGGGT CGT CCGGGGCTGC BGCB
BCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCBCCBGGBG BBTGGCBGCB
BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGCB GGGTGBCCBG BGBGG
GC GGG TCC TCB TGG CTG GGG GCC TGG GCC TGC BGG GCC GCT CTT GCC TGG BGT G
GC TC GCC CBG BGT CTT CCC TGG T CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCB
GCTC TTGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCG
BGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGGGGG TCCTCBTGGC TGGGGTCCCT
CTCTCCCGTC CT CGG TTT CCT TTG CGG TC TTG GCC CGG GCT CCG GGT G CCC GCC C
GC CCG CCG GCC GCC GC CCC GCC GGG CTG TCC CCG CCC CGC CCC GGC CCG GGG CG
C GGG GG CGG CCC TCC CGC CCC TCT GG GCC GGC GCG GGC GTC GG CCG CTC GCG C
CT GGG GTT CCC TCT CCT CCC CCT GTG C GCC TGC CTC TTG CTC TTCTGC GTC CGC
TGC CTT CTC CC CTC TCC TCG GCC GTT GCC TGT GC TGT CCG TCC TGT CGC CCT TC
C GTG GTG C TGT TGT CTC TTC TGC CCT C GGT GTG CTG GTG CTG GTG GTG GTG CC
T CTG CCC GTG CTC GCCCTG CCT GGG CTG GCC TCT TCG GGT GTG GCT TTG GGG CTC
TCT TGG TTG CCC TTT CTT CTC GTG GTG CCT CTC CTC CCT GGC TTG GTC GT TGT
CTG GGG TGG TGC TCC TCT CCC TTT CCC TGC TGG CCG TTT GT CCT GTT TTC TGT C
TT CCT CT TTC CTC CTG TTT CTC CGT TTG GCT TGC TGC TTG CGG GGC TGT CTC C
CTT GCC CCT GTG GGC TTT CCC TGG TCC GGT CTT CTC CTT GGG GGT C GCC CTT CT
T GGT GGG CTGGCT CGT CTG TCT TTT TCC TTC C TGG GGG TGG CCG TTG TGG GCG G
TG TGG TCC GCC T TGC CTC TGC TGG TCT TTC CTCGGTBGBC GCGCTCGBBC TCGGGTGGG
C CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CCTGCGCGCC GBGBTCBCCTG CBGGGBGBBG TB
GGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBGCCB GTBGBGCTBC CTCGTCCTTC BTGGTBCC
GT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CGBGCTGGGC CCCGTCTGCT GCTCCTCGTG CCG
CCTCGTC CTTCA TGG TA CCGTCGGTGT GGTGGCCTCG GGTGGGCCGG TGGTGGGGCG CGCGCGC
TCG CGTGGCTCCG GCTCTTCTTT CCCGGCTCCGT CGGCCCGGGG GCCTTGGTCT CCCTCGTCCT T
CBTGGTBCC G BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG TGGGTTTCTC CCCGCCGTTC TCBCC
CBCCG CGCTGBGCTC BGCGCCTBBG BCTGCTGTTT CTGGBGCTCC TTGGCBBGCC BCBBBCBGCB
GBGBGBBBBT CBTGBGCBBB TBBTCCBTTC TGBBBBBBBG GGBTCBBBBB CCTCCCGTTC CCCGTT
CGCC TGGCGCGCGC TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TTCTCCGGTC TGTTGCCTTT G
TGGGCTTCT TGTCTTTTTG GCTGTTCTTT TCCTGCTTGG CGTCTTTTCC TTTCTTTGTG CTCGGTT
GTG GGTCCGCTGG TCCTTTGCCC TGTGTGTTTC TGCTGCCCGT TCGCCTGGCG CGCGCTGCGG GT
TCCTCGTG GGTTTCTCCC CGCCGTTCTC CGGTCTGTTG CCTTTGTGGG CTTCTTGTCT TTTTGGCT
GT TCTTTTCCTG CTTGGCGTCT TTTCCTTTCT TTGTGCTCGG TTGTGGGTCC GCTGGTCCTT TGC
CCTGTGT GTTTCTGCTG GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGC
T TCBGCTCTGG BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGB
GGCTGC CTGBGCBBBT GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG
BGGGGCBBGG CGTTTTCTTC TCTCGCTGGT TTTCCTTTCC TGGCAGTGGG TGGGGGTGGG GGTGG
GGTGG CTTCCTTGTT CCTGGGGGTG TCCTCTTGCT CTGGGCTTTT CTCCCCTTTT CCTTCCTGTC
TGTTTTCCTG GGGCTCTCCT CTGTCTCTGT GTCCTTGCCC TGGCCCTCTT CCCTCTCCTG TCTCCT
GTCC CTGTGTTCCG CCCGTCTTCC CTCTCCTGAC CTCCTTTTCC TCCGCTGGGT GGGGCCCTGC C
TGTTCTCTG CTCCCTGGCT TGGGGTTTCT TCTGTGTGTC TTCTTCCTCT GTTGGCTGGC TTTCTCC
TTC TTTTGTCTTC CTGGGTGCCC CTTCTTCCTT TCTTGGGTCC TTGGTGCTTG GGCTGGG GCGTC
TTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT GGGGGGCCGG
GGTGGCTGGG CCCTGCTTGC CGCACGACCC CGGGCCGACC CGAGGCTCGG GGGGCTGTGT TCTGGC
GCTG GTGGGCTTGG GCCCCTCTGG GGGCTGGGTT TCCTGCTGCG CCTGGGCGCT GGCGTCTTGG G
GTGCGGGGC CGGGGGGCCG GGGGGCCGCT GTTCGTGGGC CTGGGGGTGC CTGTGGCTGC CGGTTGC
CCC GGTTGGTGGC GCCGTCCTGC TGCCGGTCGT TGGCTGGGTC CCCCCGCCCG TTTCCTGGGG TC
CGCGTGGG GTGCTCCGGT TCCTCGTGCC GCTGCTGCCT TGTCTTTCCG GCCGTGGCGG CGTGGTGG
TC CGCCCCCCCT GGCCTTCTGC TCGGGGTCTG GCTGGTTGCC GGTGCCCTTG GCGGCGGTCT TCT
TCCTGGT GGCTCTGGGC CCGGCCGGTC TCGGGCGTCT CGTGTTCGCT CTTGTGCTGT TCCGGCCGC
T CCTTCCTCTT CCGCCGCCGC CGCTCCCCGC CCGCTCGTCG CCCTGGCCCG GCCTCCTCCT GGCC
GCTGTC TCGGGCGGCG GCCTTGGCGC TCCGTTTGGG GCTGCCTCTG GCGCTTCCGG CCCTCGGCCT
GGGCGCTCTC TTCCGCCTGT GCTGGTGGCC CTCGTGGGCC CCTCCTGGCC TCCGGTGTCC TGTGG
TCCCC CGGCTGGTGG CCGGGCCGGT TGGGCGGGCG TGGGCGCCGG CGGGTCCTCC GGGCTGCCCT
TCTCCGCCGG GGGTCCCGCG CTCCTGCTGT TCCCTGGGCT CTTCTGCCTC TCTCCTGGGT GGGTGC
TGGG TGCCGGGGTC TCCGGGCTTG CCCCGCGCTG CTGGGCGTTC TGCGGTCTTG GGGTTGTCTG T
GGCCCCGCT CGTGTCGCCC TCCGTCGCCC GTCGCCGGCC TCGTCCCCTC CTGGGTGCGC GGCGGGC
TGG TCCTGGCGTT TTGCTCCTTC CTGGGCGTCT TGGGGTGCBG GGCCCBTCCT GCTGCGCCTG GG
CGCTGCTG TGCGTCCGTC TGCTGGGGGG CCGGGGTGGC TGGGCCCTGC TTGCCGCACG ACCCCGGG
CC GACCCGAGGC TCGGGGGGCT GTGTTCTGGC GCTGGTGGGC TTGGGCCCCT CTGGGGGCTG GGT
TTCCTGC TGCGCCTGGG CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC CGCTGTTCG
T GGGCCTGGGG GTGCCTGTGG CTGCCGGTTG CCCCGGTTGG TGGCGCCGTC CTGCTGCCGG TCGT
TGGCTG GGTCCCCCCG CCCGTTTCCT GGGGTCCGCG TGGGGTGCTC CGGTTCCTCG TGCCGCTGCT
GCCTTGTCTT TCCGGCCGTG GCGGCGTGGT GGTCCGCCCC CCCTGGCCTT CTGCTCGGGG TCTGG
CTGGT TGCCGGTGCC CTTGGCGGCG GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC GGTCTCGGGC
GTCTCGTGTT CGCTCTTGTG CTGTTCCGGC CGCTCCTTCC TCTTCCGCCG CCGCCGCTCC CCGCCC
GCTC GTCGCCCTGG CCCGGCCTCC TCCTGGCCGC TGTCTCGGGC GGCGGCCTTG GCGCTCCGTT T
GGGGCTGCC TCTGGCGCTT CCGGCCCTCG GCCTGGGCGC TCTCTTCCGC CTGTGCTGGT GGCCCTC
GTG GGCCCCTCCT GGCCTCCGGT GTCCTGTGGT CCCCCGGCTG GTGGCCGGGC CGGTTGGGCG GG
CGTGGGCG CCGGCGGGTC CTCCGGGCTG CCCTTCTCCG CCGGGGGTCC CGCGCTCCTG CTGTTCCC
TG GGCTCTTCTG CCTCTCTCCT GGGTGGGTGC TGGGTGCCGG GGTCTCCGGG CTTGCCCCGC GCT
GCTGGGC GTTCTGCGGT CTTGGGGTTG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC GCCCGTCGC
C GGCCTCGTCC CCTCCTGGGT GCGCGGCGGG CTGGTCCTGG CGTTTTGCTC CTTCCTGG CTGCCC
CBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT TCTGCTGCTT G
CTGCTTCTT TCCCGTCTCC CTTCTTTCCC GTCTCCTTTT TGCCTCTTTG GGTTCCTGTT GTTTCTG
GCC TGCTTGGTGG CGGCTTGTGC GTTTCCTCTC TCTTCTCTTG GGTCTCCGCT TCTCGTCCTG CC
TTTTCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC CTCCTGCCCT GTGCTGTTTG CCTCGGGT
GG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG GCTGGTTGCC TGGGCCTGTC TGGTGGGGTG TGG
GGCCGCT GGGTTGGGGG TGTGGTGGGC TCTTCTGTGG CCTGTGGGGC TGTTGGTGTC TCTGTGGGC
G TGTGCTGGGT CTTGGGGCTT CCTCCCTTGT GCTGGGTGCG GCCTCCCCGC CCCCCTTCTG GGCC
GGTGGC CTGGCTCCTT GTGGGCGCTT CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG
GCTGC GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG
GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCC
CAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT
TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGC
CCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT G
GCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTC
TCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TT
CCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAG
CG ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATG
ACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTG
A CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAG
ACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC
TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGG
GGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG
CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAG
CCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT C
TCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAG
GGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CG
GGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGAC
GA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGC
AGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCT
T TTTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCA
CGAGGG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA
ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTG
GCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC
GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCA
TGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA C
CTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAG
GAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GG
TGGGAAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCG
CG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCT
CGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCG
C CCACCCGCCT CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCAC
GGAGGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT
GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGT
CCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC TTTGGGCAGA
GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCT
GCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC A
GGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCT
CAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CA
GTTGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGA
GA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGG
TAGCCTA GAGGTGCACA GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGC
A TGGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCA
AAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA
CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCC
GGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG
GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGT
GGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA G
GAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGG
GTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GT
GTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAG
TC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGT
CAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGA
G GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGA
GTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC
TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTT
CAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC
TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCT
CGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG C
CGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCC
TCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GG
CGGGGCCG GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACT
GC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGC
GCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGC
C CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGG
CGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG
TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATA
CTGCT GCCCGAGCCC AGGTGAGGAG AAGCT TCCCAGTTAA TACATAATCA ATATGCAATT TATTA
ATACA TCTCTCCATG TCCACTCCCC CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT
ACCTTCCCTA GAGGCCAACT CATTTTCTTT GAAAAACCTG GCATTTCCCA GAAAAAAAAG TGAAGG
GCTG GGAGCTGTCC GTTGTCCTGA TTTGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG A
AGCACTATT GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACA
TGC TGTTGATACC ACCTGCCTCA TGAGTCTCAC ATAATTTGCC CTTTCACACT ATCTACCCCA TC
AGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG AATCTCCT
TG CAACCAAGAA TGACTAGACC AATGAGACAC CCTTTAAGGC CCCAGCACAA TATAGAAATC CCA
CAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT CTAGAATACA ACTAGAGTA
T AGTTCCTTTC AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATG
ATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATTAAACAAG
CATCTTGTGG ACCCCTGGGA TGGAAAGAAT AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACA
CAGAA AAGATAAAAT CATCATGGCT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC
CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCA
CATA AAGAGCTTTG CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT T
AGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATG
CTT TTTAGGTTTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC CT
CCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCATT CTCCTGGATA CACTGTCC
AC TCAGAAATAT TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TATTGTGTTA GGAGTGAAGG CAA
GAGTATC GTAAAATAAA TCAAATTTGA AATGAATTCT CTTAAATTGC TTTATAGATG TTTAATGTA
A GCCAGCAGCT ATTAAACGAT AAACCTTAAA TTCGAGAAAA ACTTGGTCAT TCAGAAACTA TAGA
AACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT GAGCTCCAGC CTGCTTCAGG AAAATCTGCC
AGTGCCATGA AGGATGTACT CTGTCTGCTC CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATC
AGCTG TCCCTGACCC ACAGGAGTTC TTTAGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGTGTTTT
ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA TGCTCAATCA AGAAAGACAC AGTCAT
TACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA A
GCATGAAAT AACCAAATTC CATAACAGAT GTTAATCTGT AATGTGTTTA GGAGAATTTA GAGGAAG
TAT AAGATTTATT CTTTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT CAATTATCCA TC
AAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTTATTAA GAACCAAT
CA TGTGGCATTT CACATTGAGC ATCATATTTA ATTCTGAAAA AAATCCTTGT ACTGTATCAT TCT
TCATATT TTATGGATGC AGTAACTAAG GCTGAGAACT TTAAAATTTT TCCTAAGTTC AGACACATA
G CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC TGCAGAGCAA ACTGCATGCC TTAA
ATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT TTGGAAACTC AGAGAAGGAA TGATCCCTCT
GCATTATAGT TACTAAGGAA TCATTGCCAT TATTTAAATG CCAGTGCTTC TACATCAGGC CCAAA
TTTTC TGTCCTACTA ACTGTGAATC AAGACTTGAT TCAACCTCTA CTTGAGTATC TGCCGCAATG
AGAAATCACT TACCTCCACT AACCACACAT TTATTTTATA ACAACAGATT GTTAGTAAGT CCTTTC
TTAT ACATACTCAA CAGCTGCTTC CCAAGATGCT GTAGGATTAT GTCTAGAGTC AAACTAGCCA G
AAGCAATGT CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTGTTT GGCCCAA
ACA TTCTAGGCAG CACTGGATAT CTGAATCATC AATTATTTCC ACAAACACTG ACCCCTCTAC CA
GTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA GCTCCCTCAT GTTACTCCCT TCTAAGTC
AA ATTGTACACC CCTTTATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA CTG
GGAATGG ACGTTTGTGG ATTCTACCTT AGTAAGGCAA AGTTATCATT GGGAATTCCT CTAATACAG
G AAGGGTGTTC CAGAGACATT AAGGAGCCAT ATAAATGGAA AATGTCCACT ACAATCCATC ACTT
GGTTGC CCCACATCAA CATTCATTCT TTTGCCACAC TTAAAGTTTC CAAGAACAAA AATTATCCCA
CTGAACATAA TCTTTACTAT CTTTTATATA AAGGAAAATT AGACTTGACT CAGCAGAACT GAAAT
AACCC AGCTCTAACA GTTACTGCTT TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA
ACAATAGTTT GGTCACATTT TCAATTTGAT ATTCTCTAGT CTCCCAACTT GATAACTGTA CCCTAA
ACCA TAAAGTTCAC TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA A
AGGAAATCT CTTAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGT
GCA GTCCTCGTTT CTGAAATTGG TCCCCTGACT GGGGCTATAC CTATTCCATT TCCTCACCCT CA
GCCAGGCA GGTGGAGCAA AAACTTAAGT CTTGGTGGAT CTGAATCTTG ATGCTGTGGA GCTGTCTT
AC TAGCCCCAGA CTACCTGCCT CTCAATTTCT AATTATATCA GTGAAAGCAA ACAGCTTTGA TTT
GTTTAAG CCTCTGATTT TTTGGTCTAA CTGATGTAAG ACCACAAGGA CAAGAGTTCT CCAGCTCCG
G ATTCTCTTCT GTTCTGTTAA TGGTGAAATG CCCGAGAGAA GAGTTGCCAA CTTTGGCAAA TAAA
AAATAC AGGATTCCAG TTAAATTCAA ATTTAGATAA ACAACAATTT TTTAGTATTA GTGTGTCCCA
TTCAATATTT GGACATACTT AACTAAAAAA TGATTTGTTG TTCATCTGAA ATACAAATTT AACTG
GGCAT TCTGAATATT CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACTTAAGA
AGACCAGATT TGAAAAGACA TTACGGATGT GTTTAAATGT CTTATTCTAG AGAGAGTTAG AGCTGT
AGGT AGAACTTGGG AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG T
GGATCACTC TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATTTGGGAA AGGCACT
TAT ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCTTATAAA TCTCCAAGAG AAATGACAGT CC
ACCATGTG GACTGCTTTC TGTAAGTCCA GGGAAAATAA AAGCTATGTG CTTGAAACCC ACTTCTGA
TA TTATAAGGTG TGTGATCTTT GTCATGTTAA TGGGTCTGAG TATCAATTCT ACAATTGTAA AGT
GACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TTGATTCTTA ATGCAACAGT AGGAAACCC
C AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTTTACTTCC CCTGCACATT GGCAGGACTC TATT
CCTCTA TTTCTCTCTA GTGCTAGAGC AGAAAGGGAC CTTGATTTGA TATCAGGAAA ATCTATTTCT
GAACCATAAG CTATGATAGC TGATTTAAAA AATTGACTAT CATGACATGA TAATGATCAT AATGG
TAATA CATATTGATA GGGTTGCCGT GAAAGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT
ACGCCTAGAC TCTCAGAAAA TGCTAATTCC AATCCCAATT GCTCTTTGCA TAAAGTTCTG TCCTAG
GGTC TGTTCTTTTC CCACATCTAC CCTCCTTGGA TCTCTCTTCT GTCTTTTTCA TGTGGTTCAG A
GGAGGAGAG AGATCCAGGT CAATGTTTTT CAAATTACAA GGAATTATCA TTTAAATGGG GAAGAAG
CTC AAGTTTTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA CA
CTGCACAT GGTTAAGATA AAGATTGTTT CCTGAAACCT TTAATTTGTG CTTACATACT CACACATA
CA TATGTGCATG CACTGGGACT CTGCAATATG CATTTCTGAC TATGGAACAT AGCCATAAAA GTC
TTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG AAAGAAAAAC ATGGTCCCT
C CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA GGGTACATCT GAGAAGCCAG CACT
TGGGAG TTCAGGGCTC AAGTTCCTTT CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CTTCCGATCA
GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTG
CCCCT CTCTTGCCTT CTGGGAGTTA TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG
GCAGCCTCTC TGGGAAGATG CTGCTTCTTC CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT CCAGAG
CTGA AGCTGGTGAG TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG A
TGTTTAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAG
GAA ATTTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG CC
TAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GGAAGGAA
AA GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCTTC TGAGCATCAG GGCTACCCAT TAC
TTTGTGA CTTTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGA
C AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGA
GATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATTTCACCT GGGAGGTTAT GGGTGGGGAA
AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCA
GGGAA GCCTAGCTCA GCTTTAACCC AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT
CAAACCCTGG GGTGCTCTGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGC
CCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC T
TATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTT
ATC TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA AG
AGGGGGTC CTGGGTCTTG TCAACTTTCA GGAGAGGGAA GACTTTGGGC TGAAAGACTT TAGTCTGT
GT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA AAAGGAGGTC CTG
TCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC TCAAGACACA CGGCTCACT
T TTCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG CCTTTTCAAG AACACTGGCT CTAG
TTCTCA GGGTCCTGAA CCCATCATTT TATGGGAGCA GAGAACAGGT CTACATAAGA CCCCCACTTT
CCCGTTTTAA CTGATATCTC CTGCTTCAGG GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAA
GTGTG AACCCTGTCC CCTGAGTCCT CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG
AAATTGTGTC TGTTTCCTGA GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGT
GGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTTTTCT C
AGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTTCCTTCCT TCTTCCT
CAC AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CA
GAAGCTTG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC CACGATAT
CA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCTTTCCAC TTCCCATTCT CCTAAGCTTC TCC
TTCAGGT CCTCATTGCC CTGAATTTTT CTTAGGACTT GGCTATAACA TGAAGCTACT CACCCTGTC
C CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG ACTGACAGTC CTTCATTCCC TTCA
CAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC
TTTGTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGG
CTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG
ACTTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGA
TCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA T
GGGGTCAGC AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTC
CAA GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA AT
GTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCAC
CT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACT
TCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGT
G CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCAC
CCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG
CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTA
CCCTT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA
ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCC
TGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA CACCGCTCCT GTCAGCCAAC AAATATC
CAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TG
GTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGG
GG TGGGGGGTTT CAGTCTCAAA ACTCCCATGA AAACCAGAGA GAAGTTTCAG AACTCCACCC AAG
AGGCTGG GTTTCTAGGG CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCC
C AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGG
GAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC
AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTG
AGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA
AGCACTTGGG TCTTGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC CATCTCTTTG AACAGC
CTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG G
ATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGA
TCA GT TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC
CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGC
CCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG
CCAGAGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTTC
CCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG T
GCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTAT
GAG ACAGAGACAC AAG CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAA
G AACCAGCGTG ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAG
TCCGCA ACCAGATCAA CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT
CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTT
CAAGA CAACGGCCGG GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA
CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGA
AACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGGTTTG G
GACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC AC TGAAGAGATG GAGGTCCAGT GAGG
GCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT
TTCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAA
ACCCC CAAACTGGCA GCCATGCACA CCCTCTTTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT
GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGC
CATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC CTTTGTATCT CCACCCACCA ATAGTA
AATT AATGTTGTCA CATTTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTTTGAAAAG G
CAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTAC
CGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GG
GTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACAC
AA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATG
TCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG TTTTCCAGG
G GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG TCCAGCTGCT TCATGTCTCT
CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAG
CTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC
CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCG
TCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG C
TGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCC
ACC TCTTCTCCCA GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC CG
ACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG GCCCTGAG
CA GAATTTCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT TCAAGGGACA TCT
TCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAG
C CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTA
AGCCTC ACATCCTTCC CTGGATGGAT GGCTGAGTCC TCTTAGGTCT CTAAGCAGAG AAAACAGAAC
TTGTCACTAG GTACTCTTTC CAAGTGGCTT CCCAATGTGC TAGTTTCTGG GCTGACAGTC AATTC
CAGGC CCTAGGACTT TGGGGGGAAA TTAGGAGCAT CCAACTA GAATTCCGTG GCCAGGACCC CTG
CCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGA
G GCCAAGTTGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCA
GCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG
TTGTTCGGGC CGCAGATTAT ATGCATGTGG CTTTGGGGCT GCTTGAAGAG AAGTTACAAC CCCAG
CGGTC CGGACCCTTC ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC
CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACG
GTGC AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC G
CCGAGTATG AGGATGGGCT GTCGCTCCCC TTCGGCTGGA CCCCCAGCAG GAGGCGCAAT GGCTTCC
TTC TCCCTCTTGT CCGGGCTGTC TCCAACCAGA TTGTGCGCTT CCCCAATGAG AGACTGACCT CC
GACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GTTCATTGAC CATGACCTGG ACTTCTCC
CC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGTTGAC TGTGAGAGGA CCTGCGCCCA GCT
GCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCAT
C CCTTTCTTCC GCTCGGCACC CTCATGCCCC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACG
CGCTCA CCTCCTTTGT GGACGCCAGC ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC
GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA GCGCTTTCAA GACAACGGCC GGGCC
CTGCT GCCCTTCGAC AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC
CTGCTTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCTT
TATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC A
AACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA GACTTTC
TGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CC
AATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAG
CC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAG
CTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCT
C ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGC
TGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC
ACGGCCTTCC AGGGTACAAT GCTTGGAGGC GCTTCTGTGG GCTCTCCCAG CCCCGGAATT TGGCA
CAGCT TAGCCGGGTG CTGAAAAACC AGGACTTGGC AAGGAAGTTC CTGAATTTGT ATGGAACACC
TGACAACATT GACATCTGGA TTGGGGCCAT CGCTGAGCCT CTTTTGCCGG GGGCTCGAGT GGGGCC
TCTT CTGGCTTGTC TGTTCGAGAA CCAGTTCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC A
GAACGAGGT GTTTTCACCA AAGACAGCGC AAGGCCCTGA GCAGAATTTC CTTGTCTCGA ATTATAT
GTG ACAATACCGG TATCACCACG GTTTCAAGGG ACATCTTCAG AGCCAACATC TACCCTCGGG GC
TTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGC
AG GAGTCTATCC CAAGTCTCCA ACTTTTGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CTT
GTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCA
G CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTA
TTAGGC TATGAATCAG CGCCACGTGC AAAGGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG
CAAGAAAAGT CAGCTGGAGG GTTTACAGCA CTTTCTACTG TTTCCCAGCC CTCCCTCCCC TCCCT
CACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA
GGCCAGGCAG CATGCTCTGC TTCTACCAAT AAAGCACTGC CGGAATTC CATATGTATG GGAATACT
GT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCTTGTAATC CTA
GCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGTTC GAGACCAGCA TGGACAACA
T GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTA
GTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA
GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATA
AATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA
TCATTTCCAT TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTA
AAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT T
TCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATC
ACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT CCCCCAGCTT CC
TGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTG
AG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCG
TGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTTGGGAC CAGAAAGAG
G TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCC
TGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA
AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAA
ATACT TCTTGGCTGC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA
GAGAACTCAG CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTC
TAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA G
GCAGTGCAG CCAGCTGCAA GGTGAGTTGC C CATATGTATG GGAATACTGT ATTTCAGGCA TTATA
AGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA
AGTGGGCAGA TCACTTGAGC TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTC
TACC AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG A
GGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACT
CCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TA
AATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT TATAAGGG
AA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG ATGAGGTGTT AGT
AAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT TTCCCTTCCA AAAACCTCA
A GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG AACC
TGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC
TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAG
ATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG
CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAG
GCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT A
AATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAG
AGA CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CA
GTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTC
CT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTT
CTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCA
A GGTGAGTTGC C CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GA
CAGTCCCG AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGT
GC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTG
ACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA AATTCCACC
A GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCC
AGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG
CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTC
CTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC TTTCCAAGAC ACACTTCACC
ATAAGGCCAA AGGGATTTTA ACTTGCAGGT CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAA
GTTT GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA A
TTTGTCAAC CAATATTACG GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAA
GCG GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GC
CACCAAGC AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGT
CT TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC GTT
ACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG ATGGCAAGC
A CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGC
ATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG
TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGA
AATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG AACATCCCAA ATACGAGTGG TTTCGGGAAC
TGGAGCTAAA GTGGTACGCC CTGCCTGCAG TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGT
TCCC AGGGTGCCCC TTCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA C
GTCCAGCGC TACAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCC
TCG CTCTGGAAAG ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CA
GAATGTGA CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATA
CC GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA TCA
CCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC AGGTAGAGG
C CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGATTCCATT GAAA
GTCTTG GTCAAAGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA
GTCACCATCC TCTTTGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTT
ATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG
AGGAACGGCT GCTGTTGGTG GTGACCAGTA CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGA
AACT GAAGAAATCG CTCTTCATGC TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG C
CTCGGCTCC AGCATGTACC CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCAC
CTG GGGGCCTCTC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TT
CCGCAGCT GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCA
CA TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG TGC
AGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TGTTCACCA
T GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAA
CTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACCTTGGGGT TTGCCCAGGC
AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGAC
AGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG CTGCCCCCCT
GCTCACTCAG CCAGGCCCTC ACCTACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCC
AAAA GCTGGCCCAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC C
TCAGAGTAC AGCAAGTGGA AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCG
TCC CTGCGGGTGT CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TC
CATCAGCT CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCA
CA CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGC
CCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCC
A TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT TCTGGCAGCA ACGG
CTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTTTGG GTGCCGCCGC
CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGC
GGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC
AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGG
ATGT GCGCATGGCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT G
AATGAGGAG CAGGTCGAGG ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATC
TTC GGTGCTGTAT TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GA
GATGTCAG CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGC
CA GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTC
AAGTCTT ATTTCCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA GTAGCACCC
T GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG AGACAAAATC TTAA
ATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT GCACCACTTC AAGTGACCAC
CAGGAGGTGC TATCGCACCA CTGTGTATTT AACTGCCTTG TGTACAGTTA TTTATGCCTC TGTAT
TTAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC ACTTGGGTCT TCCCTGTATG ATTCCTTGAT
GGAGATATTT ACATGAATTG CATTTTACTT TAATC GAATTCCCAC TCTGCTGCCT GCTCCAGCAG
ACGGACGCAC AGTAACATGG GCAACTTGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCT
GGGG CTGGGGCTGG GCCTTGGGCT GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC A
GCCGGGCCC CAGCATCCCT ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCC
AGC CCCCAGAGGG GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG AC
ACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTA
TT TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG TCA
GGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACA
G CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGC
TGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA
AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAAC
CACAT CAAGTATGCC ACCAACCGGG GCAACCTTCG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG
CCCTGGCCGA GGAGACTTCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCA
GGAC GGCTCTGTGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC T
GGACCCCAG GAAACGGTCG CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAG
AAC TCTTCCTTCT GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GG
TTTGCAGC CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGG
GG CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAA
CCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT GGATACCCG
G ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTT
ACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC CTCTTTCATG AAGCACCTGG
AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCG
GGCAG CCTCACTCCT GTTTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCTTCCGCTA
CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAA
AGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG A
AGGCGACAA TCCTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGAC
TCT TCCGGAAGGC TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AA
CACGAGAC GCTGGTGCTG GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAG
AG CTTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCA
CAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCG
G AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGTTCTGT GTGT
TCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG TGCCGTGGAC ACACGGCTGG
AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAG
GCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA
TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCT
GAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG T
TCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGG
TGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GC
CCGCCCAA CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACT
GA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCG
GGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT CACCTCCCC
A CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGC
TGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC
TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCT
CTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT
CACTGTAGCT GTGCTGGCAT ACAGGACTCA GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTC
CACG TGGCTAAGCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC T
TCCGGCTGC CACCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCT
TCC GGGGATTCTG GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TG
ACTTTGGT GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCC
CA GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA GAC
CTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCG
G GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCA
TCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC
AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATA
CGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAGTT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC
TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGG
CTGC CCGACTCAGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT C
TCACATCTG TCCAGAGGCT GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTT
TCC CTCTCTAGGC CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GC
GGTACCCC AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCT
CT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATT ATTGAAGATT TAC
CATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC-3' (配列番号
3003) ヒトファクター関連アンチセンスオリゴヌクレオチド 5'-CCT CCT TCC TGG TCT GTC TGC CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG B
BC CBT GTT TCC CBG TCT CTG BGC TGT GGC GCC CTG CTG CTC TTT CTG CT TCC CT
T GGT GGG TTG GGC C GCT GGT TGT TCT GGG GTT C TTG CTG CCC CTT CTG TCC C
TGT TTG CTG GTG TCT GCG C CCC CBB CBG BBG BBG CBG BCB BBT TTG GGB BGT GB
B CBG TTT TGG BBC CBT GTT TCC TGT GCG CTC GGC CTG GTC CCG G GGG TCT CCT
CTT GTT GTT GC TTG CGC CTC CTG CTG GGG GT CC CTC TGT TCT TGT TTT GGG GGC
GGG CCC GGC CGT TGT CTT G GTT TGG GGG TTT CCG TTG GGG TTC TCC TGG CCC G
GG CCT TGC CC GGC CGT GGT CCC GGC TTC GTTCCT GTC TCC GTC TCG GCT CTT CTG
GGG CCT TGC GCT GTC TTT GGT G GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC G
CT GCB GCG CTC GGC CTG GTC CCG GBG BGC GCG CGG GCC GGG GGC TGC TGG G GGT
TGG CCC GGG GTG CCC C GCC GCT GGG TGC CCT CGT CCT CTG CGG TC GTG TCT CC
T GGC TCT GGT TCC CC GCT GCG CCC GTT GTC CTC TGG GGT GGC CTT C GCT CCC G
GG TCT GGT TCT TGT GT TGG GGG TCC CTT TTT GGG CCT GTT GT GGC GTG GCT TGT
GTG TTC GGT TTC TGC CCT GTC CTC CGG CGT CCC CGG BGC CTC CCC GGG GCB GGB
TGB CTT TTG BGG GGG BCB CBG BTG TCT GGG CBT TGC CBG GTC CTG GGB BCB GBG
CCC CGB GCB GGB CCB GGB GTG CGG GCB GCG CGG GCC GGG GGC TGC TGG GBG CCB
TBG CGB GGC TGB G CCT CTT TTC TGT TTT TCC C CTC TGC CTT TGT TTG GGT TCG
CTT CCT TTC TGC TTC TTC C CTG TGT CTC CTG TCT CCG CTT TTT TCT TC GTC TT
T GTT GTT TTC TCT TCC TTG CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GB
T TTT BBBB GCT TGB GBB GCT GCB BBC BTT BTC CBB BGT BTB TTT GBG GCT CCB B
GG BTC BCG BCC BTC TTC CCB GGC BTT TTB BGT TGC TGT CGT BBG TGB GBG CTG B
GB GBB BCT GTG BBG CBB TCB TGB CTT CBB GBG TTC TTT TCB CCC GTT CTT GGC T
TC TTC TGT C CGT TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC CCC T
TC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G GTT CTT GGC TTC TTC TGT CCG
T TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC CCC TTC GGG GGC TGG
TGG GGC CGT CCT TGC CTG CTG G TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG T
TC CTC CTT TT TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT CTT TTC TTT TCT CT
T TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT TTG CTG TTT TTT CTC CTT CTT
CTC TCC TTT CTT TTC CTC TGT CTT GTT CTG GTC CTT CGT GGG GCT CTG TGT CGC
GTG G GTG CGG CCG TGG CC GGC GGB CCB GGB GTT GGB GCB GGB GCB GGB CGG GC
B GGC GGC TCB TGT TTG GBT CGG CBG GBG GCB CTC CTC TGG TTG GCT TCC TTC GC
C GGC BCB TGC TBG CBG GBB GBB CBG BGG GGG BBG CBG TTG GGB GGT GBG BCC CB
T TBB TBG GTG TCG B TCCCTGTTTC CCCCCTTTCG TTCTGCGTTT GCCTTTGGCG TTTTTTGT
TT GTTTTCTCTC TCCGTCTTTC TTCTCCCCT GTGGGBBTTT CTGTGGGGBT GGCBTBCBCG TBGG
CBGCTC CBBGBGCTBG CBBBCTCBBB TGCBGBBGCB TCCTCBTGGC TCTGBBBCGG TGGGAATTTC
TGTGGGGBTG GCATACACGT AGGCAGCTCC AAGAGCTAGC AAACTCAAAT GCAGAAGCATC CTCA
TGGCTC TGAAACG GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GC
CGCGCTCG GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGC
CC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCG
CCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGG
G GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTC
CGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC
TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTC
CCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC
CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCC GCACGCC
TCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GG
CAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAG
AG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCT
CCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB
CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCB
CTGBCBT CTBBGTTCTT TBGCBCTCCT TGGCBBBBCT GCBCCTTCBC BCBGBGCTGC BGBBBTCBG
G BBGGCTGCCB BGBGBGCCBC GGCCBGCTTG GBBGTCBTGT TTBCBCBCBG TGBGBTGGTT CCTT
CCGGGC TTGTGTGCTC TGCTGTCTCT TGGTTCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCTTTC
TCTTGG CCCT TGGC CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB
GTCCTTCTTG TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGB
TTBGG TBGBBBCTBG GBGGCCGGCC TCCBCCBGGG BCBTGGTCCT TCTTGTCCGC TGCCTCTCTG
GGGTTTTCGG TCTGGGTGGG CTTTCCTCCT GGGGCTGCTG CTGGGCTCTT CTTTTTGTTT CTGGCC
TGGT GCTCTCTCGT GCCCTTTCCC TTGGGTGTCT TGTTTTTGTG GCCTCCBCCB GGGBCBTG GTC
TTTGTTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGTTCCGTC CTCTGTGGTG TTTGGCCCT
G CTTCCTTTTG CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC GTTCACCTTC TGGC
ACGGAGTT GCATCCCCATA GTCAAACTCT GTGGTCGTGT CATAGTCCTC TGTGGTGTTT GGAGTTT
CCA TCCCGGCTTC TCTCTGGTTC CAAGGGAGB GGGGGCBGCB GTTGGGCCCC BBBGGCCCTC TCG
TTCBCCT TCTGGCBCGG BGTTGCBTCC CCBTBGTCBB BCTCTGTGGT CGTGTCBTBG TCCTCTGTG
G TGTTTGGBGT TTCCBTCCCG GCTTCTCTCT GGTTCCBBGG GB GGGCBCGGGG CBGTGGGCGG G
CBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB GCGCBGB
GGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GG
CTGTCGGB GGGGGTGTGG TGTCCGCTTG GCGGTTCTTT CGGGTGTTTC TTCTCTGGGT TGGCCTGC
TG CTCGTCGTGGT CGCTCCGCTC CCGGGTTCGT CTCGCTCTGT CGCCCCTTCC TTCCTTGTCG TG
TTCCTCCC TTCCTTGCCT CT GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGB
TCBCB TTTBGBCBTB GGBBBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG
BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC
TCCGGTGGCT TTTTGCTTGT GTGCTCTGCT GTCTCTG TTC CTTCCGGTGG TTTCTTCCTG GCTCT
TGTCC TTTCTCTTGG CCCTTGGCCC CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC
BGGGGGGTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGC
TTCB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG G
CGGTCCBGCCBTGGGTCTG GGGGCTGGG CTGCBGGCTC CGGGCGGGCG GGTGCGGGCT GCGTGCTGG
G GGCTGCCCCG CAGGCCCTGC GGTCCBGCCB TGGGTCTGGG GGCTGGGCTG CBGGCTCCGG GCGG
GCGGGT GCGGGCTGCG TGCTGGGGGC TGCCCCGCAG GCCCTGC GCBCCGCCTG GBGCCCTGGG GC
CCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC CBCGTCCCGG BTCBTGCTTT CBGTGCTC
BT GGTGTCCTTT CCBGGGGBGB GBGGGGCTGG TCCTCTGCTG TCCTTGCTGG TGCTCBTGGT GTC
CTTTCCG CCCTGGGGCC CCCCTGTCTT CTTGGGGCCT CTTCCCTCTG GGGGCCGTCT CTCTCCCTC
T CTTGCGTCTC TCTCTTTCTC TCTCTCTCTT CCCCTTTCCC GCTCTTTCTG TCTCGGTGTC TGGT
TTTCTC TCTCCGCTGG CTGCCTGTCT GGCCTGCGCT CTTGGCCTGT GCTGTTCCTC CTCCGGTTCC
TGTCCTCTCT GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG GGTGGTGGTC TTGTTGCTTG GGCTG
GGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGCGCTG GTCCTCTGCTG
TC CTTGCTGGTG CTCBTGGTGT CCTTTCCGCC CTGGGGCCCC CCTGTCTTCT TGGGGCCTCT TCC
CTCTGGG GGCCGTCTC TCTCCCTCTC TTGCGTCTCT CTCTTTCTCT CTCTCTCTTC CCCTTTCCCG
CTCTTTCTGT CTCGGTGTCT GGTTTTCTCT CTCCGCTGGC TGCCTGTCTG GCCTGCGCTC TTGGC
CTGTG CTGTTCCTCC TCCGGTTCCT GTCCTCTCTG TCTGTCGCCC CCTCTGGGGT CTCCCTCTGG
CGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGC
GTCT GCTGGC CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCC
GGCBG TTCCTCCTTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT
CCTBTTTCTT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTT
CBTGT TGGBTTTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCBC
GTGGTCGCTC CGCGTTTCTC TGGTTCCTCC GGTCCCGCGG GGTGCTGTCT GGTCGCTGTC GTGGCT
TGGG TCTCCGGGCG GTTTCCTTCC TTTTCCGC CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCT
CCATGGG AGGGTTGGGC TTGGCCGGGG CTGCCCGGTG CCTCCTCTTG GCTGGTCCCT CGTTGTCCT
T GGGCCCCGC TCCCGCTGCT CGGCCTCCGT GTTCTTTGGC CTCTTGCTCC GCCTGCTGTC TTGTC
CCGTC CCCTCCTCGC TTGCGTTTCC CTCTTCCTTG TCTTCCAGGC CTTCCTCCGC TTCCGCTGCT
GGGGCCCGCG CCGGGGGGGC GCTCGGCTCC GCGGCTTCCT CCCCGGCTGG GGGGTCCTGG TCTCCG
GGGC CTGCGGCTCG CGGGCTCGGG GCTGCGTGCG CCGCGCGCGG CGTCCGCGGT GGGTGGCGCT G
TCCCGCCGT GGTGTGTCTC CGTTCTCGTC CTGCGCCGTC CTGGTCTGCC CGTGGGGTCC TGGGCGT
GGT GGGGGGCGTC TGGTGCCTCG TCTGCCCCGT GGGGCTTCGG GCTCGGGGCT GTTCGTCCCC CC
TGCCGCTC TGTGGCCTCC GGGGCTCCTC GTTTTCGCTG CTTCGGGTGT CCTTCTCGGC GTGTGGCC
CC GGGTCCCGGC CCTGCTGGGC TGGGCGGGGT CGCTGCCCTG GGCTTCTGGC CCGTCTGGTT GTC
TGTCGGT GCTTGTCTCG GGTTTCTGGC CTCTGTGCTG GGCGCTTCTC TGCCTCCTGC TCCGCCCTC
C TGGTGGCTCG GCTGGGGGTG CCCGTGCGGG GGTGGGTGTG GGGTGTTTTC GGGGTCCTCC CCTT
CCC GTT TCA TCT TGG CTT TAT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG G
RG TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC
TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA GTT TCA TCT TGG GTT TCB TCT
TGG CTT TBT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TT
C CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TG
G GCC CTT CCC TGC TGG GGG GGB GTT TCB TCT TGG GGG GGB GTT TCB TCT TGG CT
T T CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TT
GTTTTCCG TTTCTCTTGC CGTCTGTGGT T GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTC
CTGA AATCCTGAGT GTTGCCTGCC AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTTTACTCTC T
GCTTACTTT TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA TCTGATC
ATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TT
CAAGGCAC CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGA
CG CAGAAGTGAA ATGAACTTTT TATAAGCATT CTTTTAATAA AGGAAAATTG CTTTTGAAGT AT
ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC CAGCTA
TGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGTC T
ACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT TACCATCACT TCAAGTG
AGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC AT
TTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG CAGCAAGTGA GAGCTGCC
TC TTACTTTCTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATTTAG GTA
GAGCACA TAAAGGCTTT ATTTCATATT CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAATAGT
T TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAA
GCCCTG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTAGCA
GTTCTGACAG CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTCTTTTTTT TTTTT
TTCTT TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG
AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTTTTGTA TTTTTCATGG AGATGGGGTT TTGCCA
TGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAACT G
CTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTTT ATAAAAATGT CATTAAG
GAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC AG
GTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC ATTGTCCC
CA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT TTC
TCAAACT GCCCTTAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAAAGG
C CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGG
TTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT
CCTTCATAAG TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTG
CTTCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC
CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA ACTCAA
GTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTCA C
AATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTCTCC
CGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT TCACCAGCTC AGATCTCCTG TG
AGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGGGTT
TG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA AAG
AGCTCTC AATTTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGG
C AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC CAGC
CCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCAAGA
GCAGGAGGAA GGGATTTTCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCA
TTGTT CTTTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG
CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTTATAA GGTGGA
AGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT T
GTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGGAAA
TAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG TCTCCTCTCA TTCCCCTCCA CC
TATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG TGTGTCCCCT CCATCCTTTT CTCCTGCT
TC TCTCTCTTCT TCCCTCTCTC TCTTTTTTCT GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT GTC
TTTCTTT CTTTCTCTTT CCTTTCTTCT ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGAACA
A AGCATTGCTT CCTTCAATAG AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT TCTA
AGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG
CTGAGACTAT GGTTGAAACC TGTTAGGTGA CTTTTTAAAT AAAAGGCAGA AATTTTGATT TTATC
TAAAG AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAACCT
AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGC
CTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA C
AGGACAGGG TACAGCCCAT TGAAACCTAC TTTTAAACCT GGATGCCTAA CCTTCATTTT CTCCTTG
ATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GA
GAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTGTGA
AA TCCTCATTTT ACCAATCTTA TTTATGAGTC CTGGGTTTTG TGAGAACAAT GGGGTTCTGA GAG
GCACCAG AGACCTCATG TTTTCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGA
G GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAG
GGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG
AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTG
TTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTATCC CATCTCAGGT CAAATACTTA
ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTTA AAATGGAGGT ATGGTG
GCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA GCTCCTACCA G
ACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA ATCAGGTTCT ACAAAAA
TAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC CAAATGACTG AC
TCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA GAAAGAAGCC CGCTGCGGAT TTACTCAA
GG CGATACTGAC ACAGGGTTTG TGTTTTTCCA ACATGAGTTT TGAGTTCTTA CACGCTGTTT GCT
CTTTTTG TGTGTTTTTT CCCTGTTAGG TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCTTAA
G AGTGGAGCCA TATGTCATCC AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTC
TCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT
CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGA
TACGC AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCTAA
TATCCTTGAA ACACCTTTTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGGAGT
GCTT TCCAGGGTCA CAGGCATCTG TATTCTTTGG ATTCCTTGAC CTTCCCCATT TATTCCCGGC A
TTTTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC CCTCACCTAC CCCACAT
CTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC ATGGAATCAT AGTGGATCTG CC
AAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCTTCTTC TGGCTAAGGT TTCTTATG
CA ATTAT CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCA
CA TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA GCC
ACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA AATGAAGCC
T CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTCAAA CTTT
GGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GGGACCAGAA
ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATTACTGC AAAAAGTGGA AAAAT
AGCCT TTGGATGGAA GTTACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT TTCCAACAGA
GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGG
CTAC CAGATTTATC GTTTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT T
TCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGT
GTC TGTCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TG
TGTCTGTC CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGT
GT TTAACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTT
AGGGCTT CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAG
A CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCA
TGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA
AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA GAGAGTAACC ATAATTTCAG CCCGA
TGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGATTCAAGG
CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAG
CTGC TTCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT T
GTTTGGAAA AATAACTTGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAG
AAC CCCACTGTTC ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GC
TCTTCAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAA
GA CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG CTA
CAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA GGCCTTGGC
C ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGAT
CTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA
CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTTTTATAA GCATTCTTTT AATAAAGGAA AATTG
CTTTT GAAGTATACC TCCTTTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGTAAAGAAG
TAGGGGGTTA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGG
GGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG A
CTGATTTTG GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTT
GCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CTTTTGTCTG AG
ATGGCCTC AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT GCGTCAGC
AG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG GCACCTGTTA CAG
AGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAA
C TT GAATTCACAT TTCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCTCTATC A
AATTTTCAT GCCTTCAATA ATTTCTAATT CATCAGTCAG TGTTTTTCCA TCCTTTACTG TGATGAT
GCC CTTTCTTCCA AACTTTTTCA TTGCATCAGA GATGATGTTA CCAATTTCTT TGTCTCCATT TG
CAGAAATT GTAGCAACCT GTGCAATTTC TTCAGGTTTG GTCACAGGTT TAGACTGCTT TTTAAGTT
CA GCAATTACAG CATCAACAGC TAACATCACA CCTCTCTTGA TTTCCACTGG ATTAGCACCT TTG
CTAACCT TCTGGAAGGC TTATTTGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GTGCCATCC
C CCAGTCTCTC CATTTGTGTT ATTGGCAACA TCTTGGACAA GTTTAGCTCC AATGCTTTTA TATT
TATCCT TTAAGTCAAT TGACTTTGCA TCAGTCACAC CATCTTTTGT TACTTTGGGA CTTCCCCAGC
TATGTTCAAT AATTACTGTT CTTCCCTTTG GCCCCATTGT AATGGCTACA GCATCGACAA AAAGT
CTACA CTTTGAAGCA TTAAGGCTCA GACATCAGCA CCAAATTTTA CATCTTTACC ATCACTTCAA
GTGAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGC
ATTT CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC T
GCCTCTTAC TTTCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTT AGGCAGA
GCA CATAAAGGCT TTATTTCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG GAAGAAATAG TT
TTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG CACACAAGGA AACAAAGC
CC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC TGGATGCATA TTTGTTTAGC AGT
TCTGACA GCATCTGACC CAGCCCTCTC TTTGCATACC CCACCAGAAC CTTCTTTTTT TTTTTTTTT
C TTTGAGACTG AGTCTTGCTC TGTCGGAAGC GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAA
TTATAG GCGTAAGCCA TCATGCCTGG CTAATTTTTG TATTTTTCAT GGAGATGGGG TTTTGCCATG
TTGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCT
GGGAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT GTCATTAAGG
ATCTTGGCTG CACAATATCG TTACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA TCAGGG
TTCT TCAGAACCTG ACATTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC C
CATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TGTTTCT
CAA ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT TCCCAAGAAA GG
CCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG CCAATTGCTA CTCTGGGT
TA CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA CACAGCCCTG AAAACATGGG GCT
CCTTCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TTGCAGCCCT ACTCGGTGC
T TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCC
CAAAGC CCTGAAGTCC TGTGGAGCTG ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT
GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAA
TCCCA TCCTCCCATT CTCCTTCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC
GTGGGGAAGA TGGGGAGTTT CAGGGGAACT TTCACATAAA TTTCACCAGC TCAGATCTCC TGTGAG
GATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGTTT G
AGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG AAAGAGC
TCT CAATTTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG CA
GCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTTTGAGTT TGTTCTCACG TGAGACAGAC CCAGCCCC
TC ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG AGGAATTTTC TGGTCCCAAG AGC
AGGAGGA AGGGATTTTC TGGGGTTTCC TGAGTCCAGA TTTGCATAAG ATCTCCTGAG TGTGCATTG
T TCTTTGAGGA CCATTCTCTG ACTCACCAGG TAAGTGGCTG AATTCTAACC TCTGTAATGA GCAT
TGCACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GACCTTTATA AGGTGGAAGG
CTTGATGTCC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTA
TCTCC TCTTCTCGTT CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGGGAAATA
GGAGGGTTGG CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTAT
CTCT CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTTT TCTCCTGCTT C
TCTCTCTTC TTCCCTCTCT CTCTTTTTTT CTGTCTTTCT TTTTCCTCTC TCCCTAGAGC ATGTCTT
TCT TTCTTTCTCT TTCCTTTCTT CTACCCACAC TTTTAGACTG AGTAGACTGA ATGCCCTATT TA
ATTGAACC AAGCATTGCT TCCTTCAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC TCACTCGT
TC TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT CATCTCTTCA CTGCTTTCCA TGC
TACAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG ACTTTTTAAA TAAAAGGCAG AAATTTTGA
T TTTATCTAAA GAAAGTAGTA TAGAATGTCA TTTTCTAAAT TTTTATATTT AAAGAGTAGA TACT
GCAACC TAGAGAATTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA
CTCTGCCCCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAG
GTTCA CAGGACAGGG ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTCATTTTC
TCCTTGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGG
ATGG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT C
TTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG GGGTTCT
GAG AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GG
AGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTT
GA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTT
TTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTTAT
C CCATCTCAGA TCAAATACTT AACAGACTAA ATGATTTGAA AAAGCAAAAG TTTACTGGCT TGTG
TGTGTT AAAATGGAGG TATGGTGGCT TTGATATTAT CTTCTTGTGG TGGAGCTGAA TTCACAAGAG
ATCGTTGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCT
TTCAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCATGTCAG
AAACTTAGAT CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG AGAAAG
AAGC CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTGTTTTTCC AACATGAGTT T
TGAGTTCTT ACACGCTGTT TGCTCTTTTT GTGTGTTTTT TCCCTGTTAG GTGTTTTTGG TGGTATA
GGC GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTCTTTTG CCCTAGAAGG TA
TAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA GGCCAAGA
AG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGTAAA CCA
AATTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT CCTAGTAATT GTGGTCATTG GGTGATGTT
G GTTTGGGCAG GCCATCTCTA ATATCCTTGA AACACCTTTT TCTGCTCTCC AGGAAGGGGT CAGG
GCTGCC ACAGCGGGGC TTGGAGTGC GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA
TACAACCTGA CCTGTGTCCA AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACC
AATG CTTAAACACC AGCAGCCCTC ACAACCACAG ATCGTGTTTT AAGGATGAGG AGGTAGTTCT C
TGGATGCAC AGGCTTCAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGA
AGA GTTGGAGCAT TGCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GT
TCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGCTTTT
GC TGAATGCTTC TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATG
CCCAGAC TCCCACCTCC TTTCTTGGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATG
C CTCAGACCAG TTCTTGGCCC AGATGATCCT AGACAATTGT TTAAGCTTAA ACTGTTCATT GGCC
AAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC
CCAAAAATGT CTGTTCCACA TAGCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCT
CCAAC ATCCCAGCTC AGCCAAATGG CTTTCATTAG TTTTTATGGT TAGACCCCAG GTCCTCGGGA
CACTGCTTTA GAAACACATT CCAAATCCTC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTCTT
TGCA GGGCGTATAC TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTTAAATATT CCCTTGGTGC A
GGTAGTTCA GCTTAGCCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCC
ATA GTTGGTTGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AG
TTCTACTT TAACCTCACC TTCCCACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA TTTAATGG
AC CCAACAGAAA GTAACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCTT TAAATAGGGG AAG
TCCACTT GTGCACGGCT GCTCCTTGCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTC
T GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACTACAAA ACTTAAACTT TACACTGAGT TTTC
ATCATT GAAGCTATGC CTCCAATCTG ACCTCTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT
GAATCCCTGC TAGGAACGTC TGTCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAA
CTTAA TAGAGAAACT CAAGCAGTTT CCTTCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC
CAGTAAGAAG ACTATCACAG GTCTTTGGAA CATTCTTTTG AGAGAAACCT ATTTAGGTCC TTGGTC
TGTT TTTCAATCAG GTTGTTTGAT TTTTGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT A
TTTGCCCCT TCTGCCATGT AGGTTTTGCA AATATTTTCT CTCATTTTCT GGGTTATCTT TTCACTC
GGT TGATTGTTTC CTTTGCTGTG CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTATTT TC
CCTTTTAT TGCCTGTGCC TTTGGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAGCT
TT ATCCTTCTAT ACACTTCTAG TAGTTTATGG TTTCAGTTGT TACATTTAGG TTTTCAATTC ATT
CTGAGTT GATGTTCCTA CATGGTGTGA GATAAAGATT TAAATACATA CATATATAAA ATCATGAGG
T AGTGTACACT ATAAATATAC AATTGTTAAT TGTTACTCAA GTCTAAGTAG AGGTGGAAAT AATA
AACTTT CTTTTTTTTA CTTAAACCAC TCTGTGTCAC TGAGCTGATT TCACCTTTAG CCTGATAAAA
TCATTGTCCT CTCCACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTC
ATGAG GATGGTAAGT CACCTGAATC CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG
GACACCAGAA TCTAGACCTC CAGAGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT TTGTTC
CCTG AGCCTGTTGA ATCAAAGTGC AATTTCTATT CTTTTTGGAA TGTTAAAAAG TGAATCATAA T
ATTTAAGCA GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAG
CAC AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA AC
CTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGTTTCT
TG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTG
CTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTTGCT GCCATTCTC
C TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCC
GGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT TTCCCTTGCA TGGGACGAAA GCTTGGCTCC
AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGA
GGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT
TGATTTTCTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTTATTTCTC CAAAGA
CTTG ATTCCAAGAA ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT T
TCTGGATCT AAACAAGTAG ACTTAGTTGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTTTT
AAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA AT
GAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA TTCCTATC
GA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACT
TCCCCGA GATTCTTTTT CTTACCCACT GCTAACTCCA TACTCAATTT CTCATGCTCT CCCTGTCCC
A GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCT
ATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA
TGAGCTCAAA ATTTGCTTTG AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATT
TCCTT TCCTCATCTC AAATAAATGC CTTGTTACAA GATTTCTGTG TTTCCACCTC TTTAATGTGT
GATATGTGTC TGTGTCAAGA CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAATTTTT GAACAA
TATA CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT G
CCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC TCCTGGT
GGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GC
AGATTGCA GCGGACATCC CAGAAGTGGT TGTTTCCCTT GCATGGGACG AAAGCTTGGC TCCAAAGC
AT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGT
CGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGA
A AAATGAGCTC AAAATTTGCT TTGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTTCT GCTC
AATTTC CTTT GATCAAAATT TTTACCTATT ATGCATTTGA TATATAAATA AGTATATAAA TGCAC
ACACA GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC
TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT CAAAAA
TAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG GGGAGGGGAC A
GTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTA
CAG GATGTGTTGG TTGTAAAAAT GCATTTTTTT ATATCTAGCT TTTTCCATGT GTATATTATA CT
TCAAAGAA GTTCAGTTAA TAATTTCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCT
CT GGCTTAATCT TGTTTTACCT TAAGCCATCA GTCATTTACA AGTAGGAAAA TTCACAGGGA AAG
TTAGAGT ATAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTTTCCAA AGCCCGTTT
A TTTCTTGATT CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TTTTTCATGT ATCTTACAAG AAGA
CAGCAT GTGCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA
TTTTTCTTGT AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGT
GGGAT TAAAGATACA GTAGAAAGTA TTTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA
ATTGGTGCTA TAGAATGGAA GTTACAGGCT TCTTTCTTTT TTCCCACAAG ATCTGCTCCT TGAGCC
CCTA GAGACTTTTC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG T
GCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAAC CTCTGAC
TGC TGCGCATAAT ACATTTCACT CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAGAGGCCA GA
AATAATGC TGAACACTGA CAACCATCTG ATCTTTGACA AAATCCACAA AAACAAGCAA TGGAGAAA
GG ACTCCCTATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTGAACCT GGG
CCCCTTC CTTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAA
C ACTATAAAAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACT
TCATGA CAAGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT
TTAGTTGTAC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTAC
AGAAT GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA
ATTTAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA CAGATG
CTTT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC ATCACTAATC A
TTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGACT ACTATTA
AAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGTT TATGCACTGC TA
GTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGATT CCTCAAAGAA TGTAAAAC
CG AACTGCCTTT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAAATTGT TTT
ACCGTAA AGGCGCATGC ATGCATATGT TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATC
G TCTAAATGCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGA
ATAGTA TGCAGCCATA AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA TGTAGTTGGA
GGCCATTATC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAA
GTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG
AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT ACCTGG
GTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG AAAACCTGTG C
ATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTTGTGGTA TAAATCT
GAG CATTCATATT AAAATAAAAT ATTTACCTCA TTAGAGTAAT TAACATTTAT TAAGCAAAGA GC
CAAGTACC TTACACACAT GATGTTTAAT CTCACAATGA TCTTTAATCT CATAACAACC GTCCATTG
TA TGTACATATG TGGAAATTGA GCCTTGGAGA GATTAAATGC ATGGGGCATG CCATTTGACT AGA
AACTGGA AGCATCAGGA TTTAAACTCA GTTCTGAATG GTTTTGTAGG CTTTGTTTTT TCCACATTA
T AGCATGGCCT GCCATGAAGA ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAAGTGA AGCA
AATATT TATTTAAATA TTCAAGATAT GCTGTTAAAT TTTTACTCAA AAATTTGAGT ACAGTATGGA
TCTTCTGAAG CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTTTAT GGAGTAGTTC TCAAT
TTTTA TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TTTTCCTCAT
TTGGACATCA GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTTTTA AAATAAAAAC CTTGTT
TTTA TATCAAGTGG GGACATTTTT TCCAAATGAA AACCGTGTAT TCATTTTATA TGATAAAATC A
ATGTTATTA TTTTTAAAAT TTTGATTTAA AAATCATTAA AAATAAATTT TCAGATATTA CCTGAAA
TTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA GACACACACA CATATATACA TA
TATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA GTTTTTAATA AAAACTAGGA GATTAATG
CC CTTTGAATGA AAATAAATAC AATGTGTATG CTTTAACATC TTGCCTTTAC TTTATAACAT TTA
TCACAGC AGTCATGAGA TAATGATTTA CATGGTCATT GTTAGTAAGC TAATAGCTAA GTGCATGAA
C TCTGGAGCTA GCCTCCCTGG ATTTTAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGG
TAAATT GCTCTTGTTC CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA
GGATTGGTGT GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCTTCA CATAC
TGAAC ACAAATATAC GAGCTGTTGT CTTATTGGGC TCATGTTTTT CCTACCACTA AGCCGCATGC
ATGCAAGGAC CATGTTGGTT TTGTTCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA TTCAAT
AGTT GTTGACTATT ATTACTAGTG GCATTTAACA AATATCTGTT AAATGAGTGA AGAAATACCC A
TTTACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA CTCTGGAGTC AAACAGG
TTT TAAAACCTTA TTCCCTCATC CTCAGTTATT GACGTTTTTT TTTTGGCAGG TGTGTGTGTG GG
ACAACTTA TTGAACTTTT CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA TTCATTCT
TG CAATGTATGG ATTTGAGACA ATTGTGTAAG TTTATCAATA AATAGTAGCT ATTTTTGTAT AAG
TATTACA TATAATATCC AGGCCACTGC TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATAC
A ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TTTA
TAGTTC ATAGATTACA AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT
AAGAGCAATT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATTTTA AATCC
GCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTTAAATGCC AAGTTCACCA
TTTTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCA
AGTT AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA TGTCCAATCA G
ATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATT TTCTTGGCAA GTTCTTT
ATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTAGCATACC CTGTTGTGCA AA
TGCTGTCT GTGTTTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAG
TT TTCCCAGAAC TTTCTTATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACA
CAAAAGG GTCAACCTGG GGGATGGCTA GGGTTTGACT CAGTCGTTAC ATTTCAATAG AGCAGGAAG
G GGAAATGGTG GCCTGTAACC TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTG
CTCTGA GGAAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA
AGCAGACTCT TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTTTAT TAAAATTTTT AATAA
CACTC AAGTATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC
TGTGGAAGAA TCAGCCAATC ACATTTGTTT ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATG
TTGC AGCAAGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG CTAGGCTAAT T
ACATATTGG AACTATTTTT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA AGAATTCTGA AGAAAAT
ATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG TT
CTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTTTGT ATTAGTATGT TTTTACAC
TT ATTTGCAAGG CATAAATAGG TTAGGTTTTG ATCTTAATTT AATTCTAACA TGTATTGTGC ACA
AGCTGTG AGCAGTTTTC AGGAGTTAGG TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTG
G TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACA
GAGAGC TGTAGAATTT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA
AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTG
TACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT
GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA TCGCAT
CACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC A
TGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCAG TCAACTC
TGC TCCCCCACAG GAGATGCCAG TGATGCATTT TCATGGCCAA CATTGTCAGT CAGCATCATT GA
ATTACTCC TGATTATAGA GACACAGCTG CAAACGATTC CCCATTAAAT ATGATGTTTC TTGCAATG
TT TGGAAGGTAC TCCTTTTTAG TAAGGGAAAT CCCCTCTTCT GGCTTGCTGA AAGTTTTTTC TTT
CCATTTT AAAAATCGTG AATTCCTTTT TGCAATATTG AGGTGGTTAT ATGGTTTCTC TTCTCTAAT
C TGTTAATATG GTGATTTAAT GGTTAGAAAT TTTCTAATGT AAATTCCACT CATATTGCAG AAAT
AAACCT AAACTGAGCA TGAGGCTATA TTTTTTATTT GCTTCTATAT TTGGTTGCTA TACAGTATTA
TGTTTAAGAT TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTATTTTTC CTTCTTGCCG ATTTT
TATCT GGTTTTTAAA TTAAGGATAT TTTAGACTTA TGAAATATTT GGCAAACAAT CCTTGGCAAG
TAATTTTTTG GGGAATTTGT TTTGGCTATT TTGAGTATTA CCCAATATAT TTTAATTAAG TTATTC
TTAA TGTTTTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC TCCAGATTTT G
TCTATTTAT ACCACTTTTC TTTTTTCCTC GATGAGTGTC ATAGATGTTC ATCTATTTTT TTATCTT
CTT TGATCTTCTC TTATTCCTTG TTTCTATTAA CTTCTGAAGT TTATTATTTT CTTTTTTCCA CT
TCCTTATG GTTTATTCTT TCAATTTTTC TCTAACTTCT TAAGTTGGGT GTTTAATTTT TAGCTTGC
TT TGCTTTTTTA GGATAAGCAT TAAAACTACA AATTTTCCTT GTTATTCTTT TGCTGCACCC CAA
ATTGTTG ATATTTCTAT TGTCTAATTT CTATTCAATT AGAATACTTT AAAGTTTCTT TTTGGTTTT
T AAAAACTAAC TTTTTAAATT GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGCATAT GGCT
TTGAAA TATATGTACA TTGTGGAATG GCTAAATTTA GCTTATTAAT GTATGCATTA TCTCACATAC
TTATCATTTT TTGTGGTGAG AGCTATGTGA CTTTTGAACT TATGAGTTAT TTAAATATTT TTAAA
TTATT AAGCATATTG GGATTTTAAG TAATTTACCT TTTTATTATT AACTTATAAC AAGTAGAACA
GTTAACCTGT ATGATTCTAC ATCATTGAAA TTTATTGACA TTTGCTTCAT AGTCTATTAT ATGGTC
TACT TTTGTTCATG TTACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA CACATATGTC T
ATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT GTTCTAGGTG CTATTAT
ATG TTGTCATGTT TAATCCTCAC CACAATTGTA TGAGGCAGCC ATAATTAATT CCACTTTACA CA
TGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATTTGTAAAG AATGAAGCAA AGATACAA
AT GAAGGCCCAC ATATCCTATA ACTAGATATT TAAGCATTTT AATTCAAGCT TTAAAACTGC TAA
ATAAAAT GTGCTCCAAT TTCTATATTG ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAG
A AATCTTTGAT GCTTCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTCCCCA GCCT
TCAGTC CACCCACCTT CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC CCAGCCTCCA
AGTCCAAACC CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCATCCT CAGGA
AAACC TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TGTGGTCTAT
AAGGGAGGCC TCAGAAGACA GGTTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAAGG GTGCTG
GAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT C
TAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGTCTTC
TGA AATTAATAAT AATAATAACT ATTACCATTA TTATACCAGT AGCTGTCATT TATTTAGTGC TT
ATTATTTG CCAGTCACTG TTCTAAATTC TTTACATGTA TTATACAACT GCCATATAAC TGCCATAT
GA GGGATGTACC CTCATTGTCA CCATTTTACC GATGAGAAAA CTGGCATAAA ACGTTTAAGT AAC
TTGTCCA AGTTACAGAG CTTAGTGAAG CCACAATGTT GCTCAATTTG CTCTCAAACT TCAAAGGGA
T GGGAAGGACA CCTAAGTCAT AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATC
TAGTCA GCCTCCTCCC ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATTTTTGCA
TGTGAATTGC AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCGCTG GATAT
AGGAA CAGTGGTTTT AAATCTCTAG GCTTTAACTT TTCTCAGAAC AAGAAATCCT TTTTGGTTTT
AATCTATATG CACATCTGTA TTTTTCTCAA TTATCGGGTA GTAAAATATA ACTTTTCTTC TGTAAT
ATTT TTTAACTTTA ATGAGTGTTC CTCATAATAG AAAAGTTTGG AAACCATTGC TATGGGTATA T
ACTTTCTAA AGGGATAGTA ATTTCTCTAG AATATTCATT TAATGCTCCA GAAGTAATTA GCACAAT
TGT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTTTA CTCCAAATCC ACATGAAACT GA
TTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATTTT TGGAGACTTC CTGGTACATT GAGACAGG
GT CGGCCAGTCT GCGTTAGGGT CTTGGTCAAA ACTGCATTTC TGAAACTAAA CTCAGATTGC TTT
CTTTTAA GGGGTCAGAA CTGATTCAAA TCTACATTTT TAAAAGCCTT AGATGTGGGG CTTTTCCTA
T TCCCAGTCTC CGCTATTGGT CTTTGTGAAT CCACAGGCAA TTTGGCCACA TCCTTGACTC TCTC
TTATAT TAAGAATTAA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTTTCCTACA
AGATCTTTGA AAAATGGAAC ATTTGCATAA GTCATATTTA GCCAGAACTG TTGTTTTATA TTTTC
CTTTC TGAATACTTT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA
GAGACCAAAG CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCATCA CGCCTG
AATA ATTACATTCA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA ACCCTCTGAC A
CCTTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA GTTTTCCCAG AAACTAG
AGT ACAAACTTTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT CTTTTTCATC CCCAGGTCTC TG
CCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA TACCTTTGTC TTAGATACTA GACTCTCC
TC CTGGTTTCTA ATTAAACCTG ATCTAGGATC TAATTTTGCC TCTGAATTCT GTTGCCCTTT GCC
AAGTGAT CTCTTCCTCC TCTGAGCCGC AGCATCTCTG AGCTTGCACA CTTAGCATAG CCATAGCAC
A CACAGCCTTA GCTTGCAGTT CAGGGTGTTT ACCTTCCCTC CCCTTCCAGA TGCTGGATCC CCAG
GGATAG GAACTCTGCC CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG TACATTTTCA
GCAAATGTTT AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCTTTTTGC TAAAC
ATGCC TGTGTCCTTT GTCATTGAAC AACTATTTTG ATCTATTTTC TTCCTGACAT AGGGGTCAGT
TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGTGA TTTTGT
TGTG AATTGAGAAC TGGCTGCCTA CTTTTGGACT ACCCACTTCA GCAAGAGTGT TTGAAACCAA A
TCTATTCTA AGTAATTTTT TATTCCCTTT TCTCTATGGC ATTAGACACA CAGCTCTTTT AAACTAC
CTT TCGTTATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA CTGTCTAGCT ATATGAACTT AG
ACAAACTA ATATCTCTGA GCTTCAGTTT CTTAAAATTT AAAATGAGGA CAATACCATC TATGGCCG
GG GATTAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAA
ATGAATT AAAAATACTG GCCGCAAACC CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA GCTTAATTT
T CATGCTCACC ATAGCACCGA TTTTCTTCTA AATATTTTGT TTCTACCAAA ATATTTTGTC CCAA
TTTTGC CTTTTATGGC TATTTCTTCA TATCCACTTT CCCAAACTAA AGAAGCAGCC CCTTCACCTT
AAACTCCTCC TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT ACAGA
GGTTA GTGTGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AGGCCAGGCT
GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGTTC TTCTCT
CTCT ACTTTCATTA CCTTCTCTCT TTTTTTTTTT CTTCTCATGT GCTCACGGGA GCAGAGAAAA T
TAACTCCTC TAAGTTTTCT TAACACAGAG TGCCTTAATT ACATATTACT ATTGTTTGAG TTCCTGC
CAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT ATCAAAAAAA GATAGCTTTC TC
CTAAAAAG GGATTTGGAT GCCTACTAAG ATAACTGGAT GCCAAGATAA GTTTAACCTA ACAAACTT
TA TTATTATTAT TATTATTATT ATTAGAGATA GGTACTTATT CTGTCACCCA GACTGCAGTG CAG
GGATGCA ATAATAGCTC ACTGCAGCCT CAAAGTCCTG AGTTCATGCA ATCCTTCTGC TTCAGCTCC
C TGAGTAGCTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTTTTAAA AAAATAATTA GGGA
TGGGGT CTTGTTGTAT TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT CCTGCCTTTT
ACCTCCCTAA TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAAAAC TTTTA
AAAGA AATCACATTA CTTACTGTTA TCATCATTAT GGTTACTACC AGTGTTAAAA CAATTGGTAT
TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTCAG ACCTCT
GAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAAAGAACTG A
AAATGGCCG GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG TTCCTGCCCC ACCTTGA
CTG AGGGATTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG CTCCCCGACT GAGTACCTTG TG
ACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCCCTTTGA CTGTAATTTT CCACTACCCA CCCAAATC
CT ATAAAACAGC CTCACCCCTA TCTCCCTTCG CTGACTCTCT TTTCAGACTC AACCTGCCTG CAC
CTAGGTG ATTCAAAAGC TTTATTGCTC ACACAAAGCC TGTTTGGTGG TCTCTTCACA CAGACCATG
T GACATTTGGT GCCGTAACTC AGATCGGGGA ACCTCCCTTG GGAGATCAGT CCCCTGTCAT CCTG
CTCTTT GCTCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA
TCTCACCAAT TTTAAATTGG GTAAGTGGCC TCTTTTTACT CTCTTCTCCA GCCTCTCTCA CTATC
CCTCA ACATCTTTCT CCTTTCAATC TTGGCACCAC GCTTCAATCT CTCCCTTCCC TTAATTTCAG
TTCCTTTCTT TTTCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACTCC AGCACT
GGTC ATGGACTTGG AAAGACAGTC TTCCCTTGAT GTTTAATCAC TGCAGGGATG CCTGCCTGAT T
ATTCACCCA CATTTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GATCCTTCAC CTTAGTG
GCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCACCTCTCC TG
GGGGGCAA GTACCCCCCA ACCCCTTCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT TGCCTCCT
TC ACTATGGGCC ACCTTCCACC CTCCATTCCT CCCTTTTCTC CCTTAGCCTG TGTTCTCAAG AAC
TTAAAAC CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC TTTCTTCTGC AATACCGCT
T GACCCCAATA CAAACTCAAC AATGGTTCCA AATAGCCTGA AAACGGCACT TTCAATTTCT CCAT
CCCACA AGATCTAAAT AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC
ATTCTTTTAC ACGTCGGTCC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAATCC TCCTT
CTTTC CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTCTTTCC AATCTTCCTT
TTCTACTGAC CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC CCGCCA
GGCT GAATCAGGCT CCAATTCTTC CTCAGCGTCC GCTCCTCCAC CCTATAATCC TTCTATCACC T
CCCCTCCTC ACACCTGGTC CAGCTTACAG TTTCATTCTG TGACTAGCCC TCCCCCACCT GCCCAAC
AAT TTCCTCTTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GGTTAATGCT CCTTTTTCTT TA
TCCAACCT CTCCCATCTC AGTTAGTATT TAGGCTTTTT TTCATCAAAT ATGAATACCT AGCCCACT
CC ATGGCTCATT TGGCAGCAAC TCCTAGACAT TTTACAGCCT TGGACCCAGA GGGGCCAGAA GGT
CATCTTA TTCTCAATAT GCATTTTATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAGT
T AGACTCCGGC CCTCAAACCC CACAACAGGA CTTAATTAAC CTTGCCTTCA AAGCGTACAA TAAT
AGAGTA GAGGCAGCCA AGTAGCAACA TATTTCTGAG TTGCAATTCC TTGCCTCCAC TGTGAGAGAA
ACCCCAGCCA CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCAAGC ATTCC
TACAG GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT
GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT CGGACT
GTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTCTGACTGA C
TCCTTCCCA GATCTTCTTG GCTTAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCC
TGG ACCATCACAG ATGCTTTTGG TAACTCTTAC AGTGGAGGGT AAGTCCGTCC CCTTCTTAAT CA
ATGCAGAG GCTACCCACT CCACATTACC TTCTCTTCAA GGTCCTGTTT CCCTTGTCTT CATAAATG
TT GTGGGTATTG ATGGCCAGGC TTCTAAACCC CTTAAAACTC CCCAACTCTG GTGCCGATTT AAA
CAACATT CTTTTATACA CTTCTTTTTA GTTATCCCCA CCTGCCCAGT TCCCTTATTA GGCTGAGAC
A TTTTAACCAA ATTATTTGCT TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATTGCTG CCCT
TCTTCC CAACCCAAAA GTGGCAACTC CTTTGCCACT TCCTCTCATA TCCCCCTACC TTAACCCACA
GGTATGGGAC ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCATTA CTATCCCATT AAAAC
CTAAT CACCCTTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTTTAAA GGGATTAAAG
CCTGTTATCA CTTGCCTGTT ACAACATGTC CTTTTAAAGC CTGTAAACTC TCCTTACAAT TCCCCC
ATTT TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA GGATCTGTGC CTTATCAACC A
AATTGTCTT GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA TCCTCAATAC CTCCCTC
CAA AACCCCTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC ATGCTTTCTT TACTATTCAT TT
GCACCCTT CATCCCAGCC TCTCTTCACT TTCACTTGGA CTGACCCTGA CACCCATCAG CCTCAGCA
AC TTACCTGGGC TGTACTGCCG CAAGGCTTCA TGGACAGCCC CCATTACCTC AGTCAACCCA AAT
TTCTTCT TCATCCATTA CCTATCCAGG CATAGTTCTT CATGAAAACA CACGTGCTCT CCCTGCTGA
T CATGTCCAGC TAATCTCCCC AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGCCCCA AATC
AGGACA CTAAAGTACC TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC CTTTCCCACA
GGGCCTAAGA AGGCCACCGT GGTCATTTCT TCCCTTCTGT CAGACATAAT TCCTTGGTTT GGCCT
TCCCA CCTCTATACA GTCTGATAAT GGACAAGCCT TTACTAGTCA AAGCACGCAA GCAGTTTCTC
AGGCTCTTGG TATTCAGTGA AACCTTCATA CCCCTTACCG TCCTCAATCC TTAGGAAAGG TAGAAC
TGAT TAATGGTCTT TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA AGGACTGGAC A
GTACTTTTA CCACTTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGTA CAGCCCA
TTT AAGATTCTGT ATGGACGCTC CTTTTTATTA GGCCCCAGTC TCATTCCAGA CACCAGCCCA AC
TTGAACTG TGCCCCAAAA ACTTGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA TTCACCAT
TC TCAACTACTT GTAAATGCCC TGCCCTTTTT TACAGTGCTG ATTTATACTT TTCCTCCAAA CCA
TCATAAC TGATATCTCC TGGTTTTACC TCAAACCGCC ACCCTTAAGT CTCTCTTAAA GTGGATAGA
A GATCTTCAGT GACAAGGTAC ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTTTACT TTTA
TATTCA CTCTTATTCT TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC
ACTATCAATC TCACTCACTC TCTCCTAGCC ATTTCTAATC CTTCTTTAAC AAACAATTGC TGGCT
TTACA ATTTCTCTTT CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AAAGGGGACT
CTGCATATTT TTAAATGAAG AGTGTTGTTT TTACCTAAAT CAATCTGGCC TGGTATATGA CAACAT
AAAA AAAACTCAAG GATAGAGCCA AAAACCTTGC CAACCAAGCA AGTAATTATG CTGAACCCCC T
TGGGCACTC TAATTAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA ATACCTGTTT TTCTCCT
TCT CTTATGCAGA CCTTGTGTCT TCCATTTAGT TTCTCAATTC ATACAAAACC GTATCCAGGC CA
TCACCAAT CATTCTATAC GACAAATGTT TTAAGGGAGG AGACCACCCC TCATATTGTC TTATGCCC
AA TTTCTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGC
CTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG TTATCTATA
G ATTACAGACA TTGTATGGAA AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTCTAAT TACC
AGTACA CGCAGCCCCT AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC
CTCTCACGCA GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCACTCG GAGAG
CTCGG TTTTTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTTCC TTCTTTAACT
CAGTGTCTGA GGGGTTTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT AATATC
ACCC CTTACCACAA AATCTTCCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA CGCCACCCCT A
ATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAAA AATTTTC
ACT GCCCCAACAC TTTACCACTA TTTCGTTTTA TTTTTCTTAT TAATATAAGA AGATAGAAAT GT
CAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAA
AG AAGTGAAAAT GGCTGGTTCC TGCCTTAACT GATGATATTC CACCATTGTG ATTTGTTCCT GCG
CCACCTT GACTGAGGGA TTAACCTTGT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGC
A CCTTGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTTCCACT ACCC
ACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTTGG ACTCAGCCCA
CCTGCACCCA GGTGATTCAA AAGCTTCATT GCTCACACAA AGCCTGTTTG GTGGTCTCTT CACAC
CGACA CGCGTGATAA TTATTATATT ACTTTTAACT AAAACCCTTT CAGAGTCTCG CAGGGAAGGC
TGTATATATC TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGT
AAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG GTAGGCTGTT A
TGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG AACAGAAGGG AAAAATC
AAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG AAAGAACTGT ACAGAGAAGT CA
ACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG ATGTCTAAAG AATACATTTA TTCATTTT
CC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC TTGCTTCTTT CTATTCTCAT TAAATCATTA GAG
CTCAAGC AATCCTTCTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCA
G CTAATTTTTT AAAAATTAGA TTTTAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA TACA
GCCCAG GCACATTGAT CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGTT CCTGGGACTC
TGACAATTTC ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAG
CACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT
AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC TCCCTG
TCCC AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA A
ATCTGAGGG CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT TCTAATCTCA GGATAAG
GAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GA
AAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGTTTCAG ATTCAGTTCA CAAAGCAG
TT TCATACTTAA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT TTCATTCTTG TTT
TATGGGC ATAGGAAGTA AGTCTCAGGG AGGTTAAGAC CAAGGTTTCT GGAGAATTTT ATATTATGA
A TCTTGATTTA TGGGATTACT ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCTT GAAT
ATAGAA CTTTATTTTT AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCTT
GGCCCTGATG TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTG
CACTG TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTTGCACATC CAAGATTTAC
AGTGTACTAT AGGGAGAATC TTTTGCAACA GCTTTTGCTA TAATACAGAA TCTGAGATGT CTTTGA
GAAA GAAAAGTGTA ATCATTACCA AAAAATTATT CTCATAATGT GTGCAAATTT GTATGAAATC T
ATATTGGCC ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC TCTATTCTCT CATAAGA
ATT CAGCTGTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGTT TG
CTGAAACT TATATCAGCA GTGCACTGTA TGCTCTTTCT GATTTATTTG AACATTCATT TATTGAGT
GT CAAGTAATGC ACTAGATACT CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGCATGTA ATC
TCACTGG GGAGAAAACA AAACATATGA TAATTTCAAA ATAACAAACT AGGCAAACTA GTTAACACT
T AAAAAGCAGG CTTTATTCAA ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCA
GGAAGA GGAGCTCATC ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG
GGAGGCCTGA GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGC
AGGGG AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTTCCATAT
GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTTCTTA CTAATAATAT CGTGAT
AAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA A
CTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCTTT TGCTTGGCAC TCATGAGATG CTAGGTG
TGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTTAA AT
AGGATGGT CCAATTCACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTTCAACTTG AGCAGGAC
CC CATTACTTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC TTTTTGAACT TTCTATAAGA GTG
TACCTCC ACAGTATACA GAAGACGACG TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACA
T ATGTATCAAA TTTGCACTTC ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTG
AAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTTTAT
GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGG
GTTGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AAATCTTCCC
AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT TTCATG
GAAG GATTTAAAGG ATCTCATGAT TTTTAGTATT CCAAGAATTT TCTTTCACCA AGGGCGATTT A
ATATGGGTC ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA AAATTGCAAA ACTTGGA
GTG TTAGTAGTAA AGGTAAATAT TCATTAGAGA TGAGAAGAGG AGCAAGGAAA TGCTTTCAGC TG
GAAATCTC AGACAAGAGG CCAGGCTTTA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAG
TA GCAGCACTTC TCAGATTTTC ATGTGCTTAC CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGA
TTCAGTA GGTCTGAGTG GAGCCTGAGA TTCTGCACCC CTAACAAGCT CTTTAGTGAT GCTTATGCC
A CTGGCGCACA GACCCCACTT GGAGAAATTT TTGTGGTGCA TACGGTCTTT GTCTCCAGAT CTAA
TGAGTC TGAAGGACAG TGTAGATTGA TTTTTTAAAT TTATGTTTAT TTTAATTTAA TTTAATTTAA
TTTATTTATT TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCA
CGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG
TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA TGGGGT
TTCA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG A
AAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTTGAGCAGT GGAAAGT
CAA GGAATTAGAA GGCATGCTTA AATGGAAAGT GAAATTGGAG AAAATTTAAA CTCATGAAAT AG
TGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAATTTAAT GAGATGGTAA CACATTTA
GT TTAAAGAAAT AAGTGACACT TTTTTTGTGT GACACAACTG TCTTATTCTT GGAAAGGACA AGG
AGAGAAT GAAATATGGT ATGTCTTCAC AGCACCTTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGG
T CTCATGATGA ACTGTCAGGG TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT AGAG
ACAAAA AAATGTTTCT GAAAACAAAA TTTCACATAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC
CTGTGTATCT TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGAT
AAACA GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG
GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATTC ACCCAA
GAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATTT TACCTTTGAC T
TGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT TTCAGTG
TGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAGCTGGTA GT
CAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGA
TC TCAGCATTGC CATTTATTGT GACCTCAGGC TATTTTATTT CTCTGTGCCT GTTTCTTTAT CAG
TAATGAA GATGTTCATA GACCCTTCTC CCACAGACTT AAAGGCATAT TTCATGATTT AAGACATGT
A AACCATTCAT AACAGTATAC AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTATTGT AACT
AACTCT GTCACTTGCT CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTTTG
AATGTGATAT CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTT ATGAATTAAT ACAGC
CTTGG TCAATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG GCCTTTCTAG ACCATCTGGT
GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACAAC TCCTCA
ATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA TAGTCTCACT A
CCATACCAC TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC TGCTTTTCTC CATATAC
CTA AATCCTATCT ATTCTTCATA AGCAACCTTC TTTATAACAT TTTCTATAAC CACCAAGCCA AA
TGACCTTT TCCTTCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT TTTTCTGA
TT TTTTTCTTTC TATATTCCTG TCTTAACTCC CCAGCTAGGT AATAATTTTC CTGAAATCAG GGA
CCAGGCT GACTCCTCTT GCTGTCTCAA GAAAGCTTAG CAGTTTCCAA CACAAAAATG TTCAATAAA
C AACTATTAAT TGACTGATTA TAAAAAATCA GTGAACCATT AAACTTAATA TAGCAATTTG CTTA
GCATGG TAATTAGCTT TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC
TTAAAAAAAA AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGGTTC CGGTA
GCCAG AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CGAGTTTGAA
AGAAATCTTC ACATCTGTGG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG AAGCCT
TTCC TCACTAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG AATAAAAAGA A
CCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC TTCACAGCCA AACATTT
TAA AAGAGATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC AGTAATGCTC AATGCTTGGC CG
TCTGACCT CTGTCTTGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACCCTTGTTG CATCCAGG
GG ATACTTACTG GTTCTCTTGG CAATGTTTGA AACCGTTCCC CTTTCTTTGT TTCCTTGGCA TTC
ATTACCC CACACTCTTT CTCCTCTTCC TTCTCCCTGC CTGGCAACAT CTTTTCATTT CTCTTTCCC
T TAGGTGACTT ATTAGATAAT GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCTT CCAT
TCTTAA AGCACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT ACCTCCTGAA
ATGTGAGGGA CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCCAAT GAGCC
ACAGT GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA
AACCTCTCAT TCTTTTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGTTT CCAGGT
GAGA AAGATGATAA TTTGATTCTT CTCTCTCACT TTTAGCCAAT TAACAGACAC ATTCAGTTAA T
ATCACCTCC TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA CAGGCGCCAT CGGTTTT
AAT CTAATAACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT CCAGGCTCAC CTGTCTCCCA CA
CTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT GTTTAAAC
CC CTTTAGTGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATACATTAG TTT
ATGATCT GGCTTCTGGT GCCTCATTTT TCCCCACTTT TTCCTTTGCA TTCTAAGCAA TGGCCCATA
C TAAGTTTGTG ATTGGTAGGA TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAATCATC TCAC
TTCATT TCTAGCATTT TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC
TCCTTTCATA GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCACTAA ACCCT
AGATA CTGAGAAATA TTTTTCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CACATGTCTG
CATCTCCTCC CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAACTG AAAAAT
ACTT GCCTCCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC ATTTCTGAAG G
ACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT TTATTCATTT CTCAATA
AGT GCTTGTTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA ACAAGAAGAA CACACCACAA TG
TTTTTAAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT GCCCTTTT
CT AATAGGGATT ACTTGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTC
TGAAAGG AAGCTAGTAG ATTTATCACC TTATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAAC
T ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGC
AGATGT GGAAACTCCT CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT GAAAATAGAA
AATAGAGAAA AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTTCAAGT AAGGGAGAAG GAAGA
CTCCC ACTCTCAAAA CTGTCTTTTG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC
AAAGGAGATT TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTTGAT
GCAG ATGCCTCCTG AGGTTCCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 TTGCTA
AATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA TCTGCCATCT C
ATCCTACCT GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAG
CTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT TTGGTCTTGT TGGTAGGAAT TG
TGCAGCCT CATCTGAGTA ACTAATGTGT TTTTATCTTA CAAACACAAG GAATATCACA TGGTTCTC
CT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AAC
TTTGTGA CATACATTTT TGTGCCATAA CTTCAACCTT GGTTCCAAAT GATTTTTGTA CCCTAAGTT
T AAATTTGGCT TTCTTTTTTT TTTTTTTGTA CTCAATAAAA CATCAAGCTC ATTTATTATT GCGA
AGAGCG AAACAACAAA GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTTGCCCAA ATTGGCTTCT
TTTTCTTACT TTTTAATTAA TTTTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CATTC
TTTTT GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGAAT
CATTTGGGAG GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA GGTGAA
AGCC CTATTTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTCTTTT CTAAACTACA A
TTTCTTCAT CTGTTAAAGA GGCATAATAA TTGTATCATC CTCATTGGGT TGATAAAATA AAATATT
TCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA TTACTGTTTT AATCCTTTAA AG
TATTAAAG ACTACTATTT GAAATCTTTT CTTCTAAAAT TCAGCCTGCT GATGACCAAG TGCACTTG
AG CAGGGGGAAT CAAATCTGAA TTAATTTCAG ATTCTGGTTA GCTTCACATA AATATTTTTT TTA
GGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTTTGA
A GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG TTTCATGCCC TGGTCTAACC CTGTGTGTTG GTTC
TGGTGG GAAATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA
GATGTATCTG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GATTT
GGCCT AAAACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAATCA
GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT GTTTCT
GGAA CTGTTCCTTA TTCCTTTCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG G
CAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAG
TCA CTTCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT TTTTCTAACT ATTAGAACCC AA
AAAGCCTA TAAATTCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACAC
AT AGACACACAC ACACACCTAA ACACACACAT AGAGATTTAT GACTTTTTAC TTTTATCCTT GTA
AATGCCA TTAACTATAT TTTGTCTTAG ATTTAGCCTG GGAATGTAGC CATTATTTCT ACCATTGCC
T CCATAGGAAA AATACTCTTC ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA GCAG
AATCAT TTGTAAGTTG GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTTTTT TTTTTTTTTT
TTTTGAGACA GGGCCTCACT CTGTTGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CCTTG
ACCTC CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC
TACCATGCCT GACTAATTTT TTGTATTTTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG GCTGGT
CTTG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGTG A
CAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTTATCTTAA AGATACCCTA AGCTTCC
TAC CAAGCCAGTG ATCTTTTGGG GCTTCTGTTT TCTTTGTTGG CATAACTGTA ACTAGCCTAA CT
GCCCGTTA TCTGTTTCCT GTTTGCCCCA CACTGATTCC CACAGCAGTT TTCAAGTTAT CGGTTTGA
GA TCTTGTACAG AAATGACTCC AAGGTAAAAA ATTTAAAAAC AACCCCTCTA ATTTTTTTAC CCT
TGCTTAT AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAGTTTGATT CTATTCTTT
T GATTCTACAA ACACTTATTA AAAGATTTTA GAATTCGGAA ATAAATAGCT TCCTTATTAA GGTG
ACTTAC AGCCCCAAAG TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT
AATAACCCAC CCTGTTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAG
GACAA CCGGGGTCAA GATTTGAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGTCA
TTCTTCTTTT GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTTAGT ACTGTA
TAAT ACTATAAGAT AGTGAGATTC AATCAGCACA GAATTTCTAA TAGCAAGGGC AGAGACATTT T
AACTGCTCA GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA TCAACAATCC CCACCCC
CCT CACACACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT AGCGCCCACT ATTCTCAAAT TT
AAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATATTTTTGT AATTGCCA
GT GTAAATGGAC AGGGGGCAAC CTTTACATAC CATATTCAGT GAACAGAATA CGTACTAACT AAT
TTGATGG AAGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGT
T AGCAATTGTT TCGAGATCAT CCCTGAACTT GAAACAGGTA TATCTTTTTT TTTTTTTTTT TTGA
GACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG
CCTCCCGGGT TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCC
ACCAC GCCTGGCTAA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT
CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAG
CCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA TGTTACAGCC T
TGAATGGTT CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTA
GTG GGTTGCTCAC ACTTTAAAGC TGAGACACAC TCATGCCTTA AGGTAAAGGG AGTGATAATC TG
GGCAGCAG ATGTTAACTT CTCAAGGCAG TCCTCCTTCT CTTTTCCTCT CCAGTGACGG ATGGTTGG
AA AGCATATATG GTGCATTTGG TTAGAGCTGT GGCCTTGGTG AATAGATACT TGGGAGAATA CAT
GGGAATT TCTCCCAGGG TTAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTCTTG AAGAGGTCA
G GTATTTGGGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAG
CATTGA AATCCAAGGC ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATTTTTT CAGAATTAAT
TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGC
AGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA
ATACAAAAAA TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT GAGGTG
GGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA CTGCACTCTA G
CCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAG
AAC CATTAGAATA TCTCACTTAG TTGTTATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA TT
TTTAAAAG TTTATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTTTTAA TGAAGGTGTG TCCTGGGC
TG ATTTACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTTGGCATC CTGCTTGTGT TGA
ATCTATC ACATTTAATT TCCTGTGGGT TTCTTTTTTT TTTCTTTTTC ACTTTAAAGT TGTGTTCTT
T TCATGTGAAG TTAAACTCAC ATACCTTTTT TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAA
CCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTTAAT
CATTGAGAAA CTTTTGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAG
CATTA TTTCCTTAGT CTATCTCATG ATATTTGACT TTTTTCCTCC TTACATCTCC CAGTAGTAGC
CCATTTGATG CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATA
GGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GATTTGTGGT T
CATAGAGTT CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC GTTGTATTTA GCTCCAT
GGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA GG
AAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATTAAT GCTTTTAC
TT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA TTTTTACATG CCAAGGACCT GCACTAATTT CTT
TCCAATG CAGTAGTTAC CACTTCCCTC TACTTCCTTC ACGAATAAGT AAAAGGGCAT GTTTAGAGA
T ACTCTTGTAA GTGTAAACTA AGTTCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA AAAA
AATCTG TCTCCTGATA CTAACATTTG AAGGAATCTA CTTTTTTACA TATTGGCAGA GGGTCTGATT
CTATCCTTAG TTCTTCCCAT TACTTTGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAA
TATAT GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG
AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA ATACAC
AGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA C
GCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT TTAAAGACTT TTGTCAT
CCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT CACATGCTAG CTTAACATGC AT
TTGCTTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACATGA
TT CTTCTCATAT ACAGATAGAT TTTGGAGGCA TTAGCTTAGT GATGATTCAG GAGTATCCAT TAT
TTGGGGA AGTAGGTGGT CATTAGTGAC CTTTTACAGG CATTTCAATG GGCTAACAGA GATGTTAGA
T TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATG
GCAAGA GGTGAGAACA AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT
TTTACAGTGA GTTAAGCATA CAAATTTATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TGTAA
ATGTT TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TTTCAGTTTT
CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT TCACAA
ATGG TTTTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTAA A
GCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACA
CTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATTTCT GAGTAGAGAC CC
TCCCTTGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATTGC TTCCAGGC
TT TATTTTCTTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCT
GTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAA
G TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGT
TTCATC TGTTCTGATA TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC
TTCCGTAAAT TCCAGTAGGT GGGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CACTT
CTAAG AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT
CGTAAGTTCA GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAAAAA
AAAA AAAAACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTTTG TTTTTCAGTT G
TTATTCTCC TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG AATAAGCCAA ATAAAAC
AAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TATTAAGTAG GACACCACAT AA
AACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATTA TTTATGCA
AT GGCAATGAGA AAAATAAAAA ACACAGTATA ACCATGCTGT ATTGCTATAA GTCATGTTAC ACA
CTGGGAG ATGGCTTCAG GGGTATTTGG TTTTTACTTT TTGTTTGGGA GGTTTTTCAA AAAAATTTA
G TTAGAATAAG TCCTTTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCT
AAGTTT GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA
CCTCTAGTCT GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GGTCC
ACAGG TGGTTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC
TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCT
CACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT G
GATTTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG GTTACTTGAA CCCTCCA
ACT TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTTTAT CAAATTGATA TG
GAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC TTAGAACAAA GCCTGACTCA TCAGAAAT
TC TAAGTAAACA TTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA GTGAGAATCC TTA
AAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCT
G AGTCTACTAG AGTATTGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCT
TTGCAA GGAGAGAATA TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC
AGTTCCAGAA TTTTAACTCT TTTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGT
TCTGA TTGGTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GTTTTCACAT TTTAGACCCT
GCCATGCCAT TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA GCCATT
ATTG CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATTTTTGTA T
TTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TTTTTTC
ATT GATTTAAAGA GTATCTATTA TATATCAAGC ATTACTCTGG GGCTTGAAGA GCTTAGATTT CA
CCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG GATTGTCATG TATGTGTGAT GTGTTTTA
AT TGCTTTTAAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATTTGAGGGG AGCTAATTTA AAA
TTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTA
G AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA CCCT
GCATAA ATGTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT
ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AAACA
TCCCA AAGGACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC
ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG AGTCAG
AAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT C
ATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACC
AAG ACAAAGAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TA
AAATAGGC ATACCAATAA CATAAGGGTT AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAGTAT
TA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTATTTCAGT TGG
TTGACAT TTAAATGTAT TTTGGTTTTA ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAAATT
A AATTGTCCAA TTCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CATTTTGTGG ATCC
CAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA
CAAGTGAACA GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAA
CTAAG AAAGCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCTTAA AGATGACATG TTTTTTGGCC
ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT AAGTGT
GGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT GGGTAACTCA G
CCTCCTAAT GATAAATGGC ATAGTTTCTT CCAGACCTTA GAGTTCTAAT TAATCTAACA AGCTCAT
TAG ATCGTGAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT CCTTATGGTA ACCCTGACAG CT
TTTATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG AAGTGAGTCG AAACTTCA
TG CTGACTTATG AAATCTTTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC TTTCTGATCA AAA
CTTCCCA TTTCTCAGAG TGGCTAGTAT CATTTTGTTC CAACCAGCTT CATGATAAGC TATAATGAT
T CCTGTGACTT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCC
CATAGT ACCCCACATC ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGCCAC
TGCATGACCA GGGCTGGCAA GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACA
TTTTA GTACTCAAAG TCATTTCTTT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAATC
AGGAAAGGTT TATTTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT TTTACGTATA AAATAC
ACTA AGCATATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC TAATATTCTG T
AACACTTAT AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT TGTTTTTAAT GAGTGAG
AAG GTTAAATGAT GACCTGACCT CAATCATTTC TGCATGCAAT TATTTCTTGG CAATCCCTTT CT
TTATAGAA ATCAAAGATT AAAAAGTCCA AATTTGCTAA AACGGTAGAG TCCAATTTAT AAGAGACC
AA ATTAACTATG GTTCATTATT AAAACATCAC TTGGAAAATG CTGGCTGTTT TGGAATTGTA GAA
GATTTTA CAGAAATATT CATACACCAA AGATAGTGCA ATTTTTATAT AAAATTATAT AAGGTTAGA
C CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGC
CTAAGT TTCCAACTGG CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTGATT
GTCTAGCTCT TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GGGTA
TAGCT TTTGTGCACA GGGACAAATC TTACACACCA AAAATTCTTA GGAGTGACAC GATGCAAGAT
TATATAGAGG GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT TCCATG
GGGT AAATCTGAGT ATTCTCTTAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGTCTTG T
CACTCCCTA CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TGGCAGGCGT CATCGTTCCA TTTGCCT
GCA TCTTTGTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT TGTTCTTCTT GTTGTTGGGC TC
ACCATCTC CCCAGTTCTC TGCTTCTTCA GTAAGAGATT TGTTGGTTCC CACCCACGTC CATATTCC
TC CTATCTTCCG GATTCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACT
CAATTTC CGCCTTGTTT TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAGCCC
T TTGCCAGTTC ATGGGTTTTT CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGG
AAATCT GCAAGACATC AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC
ACTACTCCAG GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCAT
CTCAG GATCACAGAA TAGTTGTTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CTTGAATATA
AGATGCTTTT ATCTAAGGTT CTATTTGAAA CAAATTTAGT GGTTTTCTAG GTTTATTTTC TTATTA
ATTT TTTTCTCAAA ATTATTTCAG GTGAAATTTA ACCAACATAT TTTAGACATT CATATTTCTT T
TTCTTTGTA GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA TAACTATACA ATTTACG
TAT ACTTTTTAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA TA
ATAAGGAC AGGAAGAACA GTGACATACT TTTAAGTAAC CTCTTTTACA TAAAAAACAT TTTATTTT
AC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA ATATACCACT CAACTCTTAT ATATCTAACT GTA
TAATTTT TAAAAAGAAC AATTTACAAA GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCATGT
T CTATACACAA AGAGACTCAA CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA GGGC
TTTGAA GATATCTAAT TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTAAGC
ATGGTATGAT CTACATGAAT CACTATTTAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGA
GCATC ATAAAATAAA CATTTTGAAC AGAGTTTTGA ATGAGCATTC CACTAGAATG CAAGTTCTAA
GAGGGAAAAA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA TTGTAG
GGAC TCAGAAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA GTGCAGACAT G
GCATAAGGA ATGTGTGAAC GGGAGAGTTA GCATGTTTGC TTGGCTAGAG CTGAAAATCC AGGCTAG
GGA GAAAGAAGAC ATTAGTTTAC TTAGGAAATG AAAAACCAAG TTCAAAGCTA TTGCTGGAGA GT
CTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCCCCG
TC CCTTAATAAG CTCGTATTGT AATTGTAGAA ATGACATTAA TGTACACTGA ACTATGAATA AAA
AATAGAA AATGAGGTGC TAAATATTTG GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAATTA
A CATTATTCCT TTATAATTGA GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT GGGC
TATTAT AGGTTAAAAA TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT
GTTTACAGAA GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA ACTAG
TGGAT ATTTAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC
CACAACAGAG CATTGTCCAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC TCTGAC
ATTT CCATGGAAAT ATCTGCAAAT GAAATACAAA ATTATATTTA GATGTATACT CTTAAACCAC A
CATTTATAG CCTTTGAGGT GGTGCTTACA ACTTTCTTAA TAATCAGAAT AAAACACATA TGTCTAC
TAA CCCTGTCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA ATTACTTCAA ATTTACATCA GA
ACTGATGC ACAGTTTTGT TTTGTTCTAT TTTATTTTTA CGCTTTAGTC TCAAGTTGCT AATCGGTA
CT GCCCTGAATT TTTTCTATGG TTTGGTAATT TTTATACCTG CTTTTCTGCT GAGCTATTAG ATA
AAACTAT TTAATATTTA CTATGTATAT TTTTTAAAGT ATTGTTGCTG CTTAATTAAC TATTGATGC
T TATATTTAAT GTTATAGCCT CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAA
AAAAAA ATTAGATAGC CAGACACCAG GAAAGAAAAG TATTTCTTTT TTTAATAAAA AGAAATACCT
TTTTGAGCAA CTGAAATGAC AAAGTCACAA ATTTCCTGCA CACCTTAAAA TATACTTAAT GTAAA
TGACG AGTTAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT
TGTGCACATG TACCCTAGAA CTTAAAGTAT AATTTTAAAA AAATTCTATC TTCCAAAGCA TATCAC
TTCT CAGGTAGACA CAGTGTTTAT TGCAAAAGAT CTGATTTCAA TAGTATTTCT TCAAGAGTCT C
CCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA TTTCAGGATC ACTTTTT
TTG AGGGTCTGAG AAAATGTTTA GTTTCTATAT TATTTAAAAC CAGAATTGAA ATGGGGTGAT TC
CTATCCTT GCCACCTGCC TCTACAACCC CAAGAGTTTC TATCTGAGCA TCTAAACGTC TTTTAGGC
TG AAAGGCTCAC CATGGCTTTG CTTGGTCCTT CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC TTG
ACTTAGC ACAAGGGTCT CAGGTCCTTG CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTG
A ATGTCAACAG AAAGCCTTGC TTTCTTTCAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT CCTC
CCCTTT TCCCTCCCCT TCCTCCTGCA CTTCTCTTTC CTCTTTCCCC ACCCCTTTCC TAGACTGGCC
TCTATTGCCT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CTCTC
TTCCT TCCCTCCTTT CTATCCTTCC TTCCATTCTC CTATGCATCT TTCCTTACCC TCCTCCTCCT
TCACTCATTG TTGTTGCTGT TCTTCTTCCT CTTCTTTTTC CTCCTGCTCC TCTTCTTCTA CTTGTT
CTTG TTCTTGTTTT TGTTTGGTTC TTGTTCTCCT CTTCCTCCTT CTCTCTCTCC TCCTCCTCCT T
CTTTTCCAC CACCCTCCCC TATCTTTTTC ATAAATGCTA AACTAACTCT TGGCTACCTG TGGTAAA
TGG CCCTTGGAAA TTGCAAATAC TACAAATCAA AACTGCATTT CAGACATATT TATGATGTTT GC
AAAACTTC AGTAGAGCTA AGCAGTGGAC TTGACTCGTT TCGGTTCCTT CACCTCCGTC TTTCCTTG
CT CACCACCTAG TGGACGTCCT TGTTAGTGGC ACTTCCTGAA GTTAACCCCT GAAGAGAGCC CAT
GCTCTCT AGCTTTTCAC CGTGTAGGTT TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTATAA
A ATGAGATGGT TTTATAAGAC TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGG
AAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGATTTG CATTTTTAGG AAAATAATAA
TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATATTT ATTATATTGT TTAATCTTTA TAACA
GCTCT CTGCTATAGA TATGATTATT ATCCCCATTC TAAAGAGTCT CAAAGAGGTT AAGAAACAAA
TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACG
AAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGATTAAC AAAATAGATG G
ACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATT
ACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT TTACACAAAT AA
ACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCAGGA
AG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TAC
CAACTAA AAAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGC
T GGTACCATTC CTTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATTT
TATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG
CCAATATCCC TGATGAACAT CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAG
CACAT CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA
CATACACAAA TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT GATTAT
CTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAAT A
AACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA CAAACCCACA GCCAATA
GCA TACTGAATGG GCAAAAACTG AAAGCGTTCC CTTTAAAAAC TGGCACAAGA CAAGTATGCC TC
TCTCACCA CTCCTGTTCA ACATAGTATT GGAAGTTCTG GCCAGGGCAA TCAGGCAAGA GAAAGAAA
TA AAGTGTATTC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTTTGCAGAT GACATGATTG TAT
ATTTAGA AAATCCCATT GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCT
C AGGTTACAAA ATCAATGTGA AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC AGAG
AGCCAA ATCATGAGTG AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA
CTTACAAGGA ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGA
GGACA CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA
CCATACTGCC CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT TTTTCA
CAGA ATTAGAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT ATAGCCAAGA C
AATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC AAACTATACT ACAAGGC
TAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AG
AGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCTTTGACA AAGCTGACAA AAAGAAGC
AA TTGGGAAAGG ATTCCCCATT TAATAAATGA TGTTGGGAAA ACTGGCTAGC CATATGCAGA AAA
CTGAAAC TGGATCCCTT CCTTACACCT TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTAAAT
G GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTAT
GGGCAA AGACTTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA
TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAA
ACCTA CAGAATGGGA GAAAATTTTT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAATCT
ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATAT
GAAC AGATGCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA T
CACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAATGG
CGA TTATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTTT TT
ACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT GGAAGACAAT GTGGCGATTT CTCAAGGA
TC TATAACTAGA AAAACCATTT GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATT ATA
AATCATT CTACGATAAA GACACATGCA CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGA
G TTGGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATC
ATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG
GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCAT
AAGTG GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT
CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG GTTGAT
GAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT CTGCTCATGT A
TCCCAGAAA TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG CCTTAGTCAC ATAACTA
GTA AGAGACATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC CAAATCCATG CTCTTGATCA TT
AAGCTGAA CTTATGGCAG GAACTTGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGGAGA
CT TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTT ACTTTTTTCT AAG
TCCTCTC CTCTAATTCT CTCAATCTCT CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTGTCA
C TCAGGCTAGA GTGCAGTGGT GCGATCATAG CTCATTGCAC TCAAGGAATC CTAGGGTCTA GTGC
CCCTTC TCCCTCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAATTTT
TTTATTTTTT ATTTTTGTAG AGACAGGATC TCACTATGTT GCTCAGGCTG TAATTCTGTC TTGAA
GCTTG TCCAATCAGG CTTTCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT
TCACTAACAC AAACAGCCTA TTCTCCATCC TCATCTTACT TCACCAGGGA GCTCCTGGTT TTCCTC
CTAC TTCACTGGCT ATTTCTTCTG TATCATGTGT TGATTCTCCC TCATCTCCCC AACCTCCAAA C
CCTTGGAGT ACTCCAGAGA TCACCGCTTT GCTCTTCTGT GTCTAACCTC ACTAACTTGG TGGTCCA
ATT CACACTCTTG ACTTTGAATA CCATTTAAAT GCGAACGAAT TCTAAATTCT GTACAACCAG AA
CCATTCTC CTGTAGCCAA ATGCCTACTC AACATCTCCA TCCCCAAACA AATTTAGTTG TTCAATAA
GC CTCTCATATT TTACATATCC CAAACTGAAC TTCTGAATTT CTCCTCCAAT CTGTAGGGCT CTT
CCCACAG CCTTTCCATC TCAGTGGATT ATAACTCCAT CCTTCCAGTT ACTCAGACCA AAACTTTTG
G AGTTAACTGA GACACCTCTC TTTTTTTTCA CAAGTCATAT CCAATGTGTC AACAAATTTT GGTA
GTGGAA ATATTGCGGG ATTTTTTAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATATTTATTA
TTTAGGTGCA CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGTT AAGTT
ACCTT TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA
GTGAGAAATA AAGACAGTTA TTCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTTT TCAAGA
AGAA ACATGTTTTG CGACTTGAGT TTATCTGTCT AGTGACCTTG CAGCTGCACA GCTAGAGAAA C
AGGGTCTTC ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGT
TAA TTTTTAAAGG GCTCCAGCTC TTTCTCTTTC TCAGGGGGAG TTGGGTTTTG TTACATACAA CT
GAGTTTCC GCTTACACAT TATTTAATTT CTTTTAATTC CTGTTCCAAA AGAAGCCAGA TACAAAAG
GT TACATGTTGT CTGATTCCAT TTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAA
GTAGATT AGAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAGTTT
T CTTCTGATAA AAATATTTTG GAACTAGATA GACATTTTGT TAGGCCATTC TTGCATTGTT ATAA
AGAATT ACCTGAGACT TGGTAATTTA TAAAGAAAAG ATGTTTAATT GGCTTACACT TCTGCAAGCT
TTACAGGAAG CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTACA ATCAT
GGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG
GAGGTGACAG TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA CAGTAC
CAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA G
GCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA GAACACGGAT CCAAACC
ATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA TTGTACACTT TAAGATGGTT GT
TTTATGTT GTGTGAACTT CACCTCAATA AAAAAAAATA TTTAATGTAC ATTCAGCCAA AAGAAGAT
TT GGAATAGGAA AGGTCATGGA GATATATTAA CAGCCATTTG ATGGGTGGTA AGGAAAAGAG TGG
TTATTAG ACTGTTTTGT GGCCCTCAAA AGGTAGAACT AGATCGAGTT GGTGAGCATT ATAAAACCA
T CACAAAACCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TGAGACATGA GGGA
AGTACC AGTGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC
AACCCTTCCC TAGCCTACGC CTCCATTACA GATGACCGCA AGATTTATTT GCTCATTGCT GCCAA
CCAAG GCTGCACTCA CTGCAGTTGC TATCAGTTTA TCATGGGTAA AAGGAATGTG CAGTAGAGAA
CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT TCCTTA
CATT TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA CCTAAACTGT T
CTCTCCTGA CCCAACCTTG ATTTTCATCC CAAATGCTTC CTTGCCATCT CTGGGATTCC TGTCTTC
ACC ATCACCAAAC TCCCCTCAAT CTTCCAGTTT CCTGTTCAAA CTTTTCTCCT ACCTCCTTGC TT
TGTCATTA GCCCGACTGC CTCCCTAGGA CATCACTTCC CCTGCAGATC TCTCAAGATG ACAATATT
TA TTCTCCACAC AGCACATACT TCAGGGTTGG AAGGCAGGGG CAATCTTCTC CTTTATAATG AGT
GCCTCTT ATATATGTTT ATTCATCTGC CCTCTTGTAA AACACACACA CACACACACA CAAAGAAGA
A ATAAAATAAC TCTGCTTCTT TGAAGCTTGT GACACTGAGA TAAACCATCT CACTGTCCTC ATTG
TAGTGA CCTCTCAACT CCTCATGCAA GATTGGCTTT GGCACCTAGT TCCTGATCTT CCTTTCCCTG
TAAGCACTTC TCATAGTCTT ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGAT
CCTCA GCTCTCCAAT GACATTTTCC TCCACTAGAC TTGAGCTACC TCCTTCCCTA GGCACAGCCT
CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTTCAA ACACTTCACT CTTTAA
CCAC TGTCTCCTAT TCTTGCAAGT GTATTGCTCA AGTATCTCAT TGCAATGCTT TTTACTTCTA C
CTCATTGAA CCTCCAGGCC ATTAAACATT TCCTTATTTC TAACCATCAG GTTTCTCCTT ACTTGTT
TGT TTGTTTATTT GTTTCTTTTT TTTTTTTTTT TTTGAGACAG GGTCTCACTC TGTTGCCCAG GC
TGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTTCAAGTGA TTCTCATG
TC TCAGCCTCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGATTTTGT ATT
TTTATTA GAGAAGGGGT TTTGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCC
A CCTGCCTCAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT TTCT
CCTTAT TTATTTCAAG TCTATGCTGC ACTATTAAAA CTGCCTTGAC AAAAATTATA ATAGTGAGAA
AATTATGACA GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCTTT ACCTTCCAGA CTGCC
CTTAA TAATTCCTGA GCTTGGGCCA AGCTATCTTT GGCAGAAATT TAGTTTATAG TTTAAATGAT
AATAGCCCTT CTCCAAAACT AAACTGCCTT TGTAAAACTA ATAAAAGACC ACCAATGAAA GGTTAG
GAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC TGTTATTCCG G
AGGTCACAA GATTTGCAAC ATCGCCAATT ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTGATT
GGC CTTTTGAGAT GTCTTTTCAG ATTCTTACAT TTCAACTGGT GGCTCTACCT GGACCCATCA AC
AAGTCCTG TGGCTCCACC CAGAAGCAGA CTTAACATGC ACAAGGACCA TTTTCCACAC CGCTATGA
TT GCATCCCAAC CAATCAGCAG CAACCATTCC TCTGCCTGCC AAATTATCCT TGAAAAATCT TAG
CCTTAGA ATTTTGGGGG AGGCTGATTT CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGGCTC
T GCATGAATTA AATTCTTTCT CTATTGCAGT TCCCATCTTG ATAAATCACC TTTATCTGGG CAGC
AAACAA AAGGAACCCA TTGGACAGTT ACACTGTTGG CAGATATATC TTGCTTCCAA AATTGGATTT
TTGTTTAATG AATTTATTCT GTTTTCTTGA TATTTACAAC TGTGAATGTT GTGTCTGAAT TCTCT
TTATT TCTTGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG CTAATTACTC
AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA TTGTCCACTT TTCCCA
AACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA AATACCACAT A
GACATCAGG GACACTTTAA ACTAATCAGC CTATAGTCCT TTTTCAGTAA TTTCCAAACC TGGTTGT
GCA TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA TC
CTACTGAA TCAGAATATT TTGGGTTGGT TCAGGAACAT TCAGGAGTTT TTCAGGGTCC AAGGTTTA
TA TAATTTGAGG TCTCTCTTTG AGAAAAGGAA CGTAAAAGCG TCTTGCTTTT ATAGATCTTA CAA
AGATGTA TTACCATGTA AACACATTCC TAGGACCCAG GCCCTTGTAA TTTAAAGGTT TATCTAAGT
A ATGGGCCCTG AAGCTTAATT TTCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTTT AGGA
ATATAT CTCTCTGTGT ATGTGTGTGC ACATTAGCAT GTACGCTTGT GTGGATTTTT TTTTTTTTTT
TTTTTTTTTC TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCT
CACTG CAAACTCCGC CTCCCAGGCT CAAGCGATTC TTCTGCCTCA GCCTCTTGAG TAGCTGGGAC
TATAGGCACG CACCACTATG CCCAGCTAAT TTTTGTATTT TTAGTAGAGT TGGGGTTTCG CCATGT
TGGC CAGGATGGTC TTGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTGG G
ATTACAGGC GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGTTTTAAGC TCCCAGGTGA GTGAATA
CAA AACTAGATCT TTCCCTTCTG TAGCATCTGT ACTGTTTACT CTATGCATCT CAATATTTTT TC
TTTTAGTA TCTTTCCTTT TTCTCTCTTA TTACTTCCTC TTGTGCTATT TTTACACCTC CTTTTTTA
AA AAATTTTTTC CCTTTTATTT CTATTGACCT TTAGCCCTCA CAATGATTCC TACAAGCCCC ATT
TCTGTAA ATGGGGATTG AAATAATTGC TGGACTTTTG AGAGATAGAT ATATTAAATT GCAAACTGG
C AGTAGTGGGG GCAGTTGATA CATAACTAGG TTTTAAAGTC TAGCCTTCTG AGACCACTCA TTCC
ATTTGT GAAAAGTGAT TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC CATGCATTGA
TTTATTCATT CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGA
ATACA GCAATGAACA AGGTAATTTT TCCCTACCCC TAAGGAACTT AGAGTTTAGT GGGGAAGACA
GACATTAAAC AAACAATTGT GCAAGTAATA ATCTATAATT ATTTATTACA ATTAAAGGAA GGAAGA
GACA TATGGATTAT GAGGGCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC TCGTGAAGGG A
CATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGT
GCG TGTGTGTGTT GGGGTGTGGG GGTGTGGTAT TTTTTATAGA AATTGTCTCA CACAATTATG GA
AGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TACTTCAA
AG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCT
TAAAAAG ACAGTGAATT CACTCTTTTT GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACC
C ACATTGGTGA AGGCAATCCT CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT CTCA
CAGACA CACTGAGAAA TAATGTTTTA TCAGGGTGAT AGAAATCTTC TGGAGTTAAA CAATGGTGAT
AGCTGTACAA TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG TTTTATCTAA ATAAA
ATTTC TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATTGTCAAC CTTTATAGTG
TTATGTCAAA TAGGTCTGAC ATAAGCTTAA ATAAATATAT ACTTTAAAAA TTATAAAATA TTTTAA
GTTA TAATTTAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTATTTCA CACAGCTAAT T
TCTAATGCA GTTTACATAA ATATTTACAA CACTTAAACA ATTTCAAAGA AAATAACACT GTATTCC
ATA CATAGCCTGA TCACAGTAGT TGTTCTCTCT TATTTCCCAG AGTTTTTCTG CCCCTTTAAA AG
AACCTCTG CTGTTCTGAT CCTTATCACA TCTCTGTTTT GACTGTTGGC TTTGTTGTTG CCAGTGTT
CA GCCAGAACTT CTCTGAAACT TTTTTTTCAA CACATGCTAA GTTAATGGAA GTGTAGGAGA GTT
TTGATTC TCACACTCCT CAAGGCTAGA GCAGCTTTGG CAATTACTGA CTGAGAATTT TTCATTGCC
A GTGATCAACT GAAAACTGGA GATTCCTTTG GAATTGTTAA ATCTGCTTAT AAATAAACAT AAAT
GCTTGC TCACACAGGC ATTCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA
TAACTATTAG ACATCTTCAT TCGTTAAAAA TCTACCAGAT GACTCTTTTA CATGGTGAGT TTCTA
TTGTG AATTTAAAAT CTTCCATAAT ATACAAGAAT TATGTTTACA TATCATATCT GACAAACATC
TTTGTAGGAA TGCAAAGCAC ATCCATCTTT CTGTATTCTT TTCCAACAAA GACATTCATA AAATTA
TACC TTTGTGTGTT TGCATTTATG CTTTTATTAG TTCAAAACGT TTGGCCTCAT GGAAGTTTTT C
ATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC TTCCATTCAG TTTTTAC
TCT CCAATTCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA CACTCAGAAC TTTATTCTGG TT
AACATCAT GCCTTGCTAG GGGACAATAG TTTCCCTTTT TGAAATAAAT TTAAAACAGA TGTAACAT
AA TTTGTTAATA AACAATGAGG GGGTAATCTA GAATAAGTAA CTTTTACCAT ATCATAGTTG ACA
GCATTTA CAAGTTTTTT AAGTCCCTAC CACACTTGTA TTGAATGAAG AAGTATGGAA GATTATAAT
A TATTCAATGC AAGTAAAAAT ATCACAATCC TTAAGAACTC TTTAAGAAGC ACTGAATCCC ATAG
GGATGA AAGTGATTAA ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TTGCACCATT
AACAACCCTC CATGCATTTG CCTGTGGGCA TTCAACATCT GTCATTTTTT TAAGTTATAA TATTT
TTAGT CATTTTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA
TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG TGCCAA
GATT TTACAGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC TTGGTCTCTT C
ACCTTTGCT TGGAAGAAAA TATCCTTTCC CTTCATTAGC CAACACTTTC TTGATCCTGA GAGTAGG
AAA GGGAACACTG AGTCTTTTCA GTTGAAGGCC GTCCTTGCCT GCTGGACTTT GATCTATTGA AG
TGGTGATG GGTGTTGCGG TTTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGAC
CC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA GTGTATCCCT CTAGTTCCCC AGATGCACCT GTT
TCTGTAA ATATAAACAT GCATGTCATC AGAACACTTA ATATTCTGCA TACTGATCAT GACAACAAA
A TGTACCTTCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT TCAG
TTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC
AGAGTGAATT CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAG
TTGTA ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG
AACTCTTTGT GCTTTCTGCT CAATTTTTCT GTAAACTTAA AACCGCACAC ACAAAAAAAG TTATTT
TAAT TTTTTAAAAA GTATTCAGAG GGACTTGACC TTTCCAAATT CTCTCAAAGC AGGTCGGAGT A
GTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC TACACCACTT ACTAGCT
TTG AGATTTCAGA CAATTTACTT AACTTCTCTG TCTCATTTTC TTCATCTGTG TGATAAGAAA TA
AAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTTT GAGAGGCCAA GGCGGGTG
GA TCAGGAGTTC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TAC
AAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGA
A TTGCTTGAAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAG
GCAACA GAATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT
AGTACCAGCC CCTATCTCAG AGTTCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGT
AAGGG TCAGCTATCT TCATTATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG
TTTCTTTCCT CTCCTTCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG ATTTCT
CCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG AGCATGTAGA G
AAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC TTTTGAACTT AAAGGAT
GTA AGAAGGCTTT TGGTAGCTTC CATCTGATTC AAGGCTTTGG CAGCTGCTGT GGAATACATG AG
AACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGCATG
CT TTGTATAAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TTGCTGCAAA AGAAAAGACA AAC
AACCATT AATTCAGACT AAATGACTTT TAAGGATATA TTAAATCCAG ATACAATATG ACTTAATTC
A TCAAGTGTTG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGT
GGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA
AATAGCTACG GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CTTAA
TTTAA ATGTGAGATT TCCTATTTTG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACTCT
TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA GAGACT
CTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT TTTCCTTAGA G
TGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACC
CCC TGGAGTTGTA CAATATTAGG CACGACTAAC ATTTTTATTT CCTGAAACAC TTCCCACACT GA
GTTGTACT ACTAACTCTT TTCTTAATAC TTCTGCTTAA TTATACTGCA TTTTATCCAG ATTCTAAT
TA TTGTTTAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATTTTCAAAA ACA
TTTTTGA AGTACATTCA TAAACTTCCT CACCTTTCCG TAAGCATTTC CGAAGCCAGA GGAGAAATG
G TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCA
GTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA AGTCTCTCCG
TCCTGTCCCT TTGGCCTTTT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAAT
ACAAG AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT
TCCACCATTG GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC TTGGTT
AATA AACACTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT TCCCCTTTCT C
CTCTCCTCT CTCTGTCTCC TTTTTCCAGT TGTCAGAATT CTACCCTTTC CATCAACATG CAACTTC
TGT TTTTTCTCTA TCCCCATACA ACTTAATATT CACAACTTGT CAACCTGGGC GAACTTTCTG GT
TTGGATAT AATGAATAGT TGATTACTGT AACAAGATAG CTCCCCCTTT TTCTTTTTAA TCACCAGA
CA ACCACCATCA ATCAATGCAT CACCTTCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGC
TCCACAT GTCCGAGCTG CAGAGCCATT GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGT
G CCAAACACGG GCTCCCCACT GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA CATT
TTACCA CTGCAAATGT TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAAAAC
TTGCTTAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTTTTC AGCATGTAGG AAATT
AGGAC CAAACCCCTT TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCCTA
AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG AGATGT
GCAC TCAAGTTGAG TTGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC T
TGTAGGTGA ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGACAG
CAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA GTTTGTTTGC ATCTCCAGCA AT
ACGTTTCC CAAGGTAACC AAGTTCCCAA GCTCTTCAAT AGTTCTTTTT ATCTTAAAAT AAAATAAA
AA CAAAGACTGT ACCTTCACAT GTGGGCTTCT CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGA
GCCTTTT GGATCCCTTC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGA
A ACTGCCAGAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCAC
TGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT
TTGTTGAGTG AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CCCTG
GACAA ATGGGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATT
AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATTATG
GTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT ATAGATGGTG C
CAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTTGCAG TTTGGTTTTT GTGTTAT
GTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AA
AACTGCTT GTTTTCAATA TCCTTGCTCT CACTTTAAAG TGAATTAAAA TTTACTGCTT ATATATGC
AT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCA
TTTCAGA AGACAGGTGT GATGAGAGTT TTACATTCAA ATCATGTTCT CATTATTCTG CTTTCCGAA
T TTTCTAATAT GATTCCTTTA GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TTTT
ATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TTCATTCTTA ACACATATGA TCCTTTCCCT
GGCCAAACAT TAGTTCTTTT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTC
TATAG TTAAAGTGGG TATTGGTTTT TTTTTTCACT GTCCAAGTTT GAAGATGGTT GTTCTTTAAG
AAAGTATAAA TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT GCCCTT
GAGT GGTGCATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTTGCA G
GATGATTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCATTCTG AGGCTGG
CGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG ATATTAGCAC GGCCTAGAAT TA
GCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACT
CT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGC
TCCCATT AGTTCAAATC CTTCTTCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGG
G TTTTGGAAAC ATTCCACGAA CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT GAGG
ATTTTA AAGAGCACCA TGAATTTTAC AGAAGAATGA TCTTTTCACT TCCTATTGAG CTGGGTGCCT
AACAGAGTGA GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GACAT
GCACA GCCAGAATAA AAGCTTTTAT TCTTTTTCAT GGATATTCTA TCTTTTCTGA TTTCCACTTT
GCCTATGCTG AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA AATAGA
TTCC AGATTAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT TAGCCCATCA G
AGCCTGAAG AACTGATTTT TCTTTTTTTG GCCTCTGGTT CAGAAAGATA AAATTAAGAG AGAAAAA
GAG ATACTAAGAC TGCTTGACTA TCATGGTCTT AAGTTAGTCC CATGGCTTGG AAAAGTTAAA CA
GGGAAACA AGATGAGAAA TCCATTGAGA TTTCTAGAGC TTTATTGTTT TATGGTCTCC CTTACAAA
TC ACCAGAGCCT CAGAAACACC CATTTCAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAG
GTACTGG GTTGGCAATA TACATTGGCT GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAA
A CTTTCCCTGA AGTTTTGAAA ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTAC
AGAACG TTCTGTGCAT TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTCTCC
AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGC
AGGAA GAATTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGGAT
TCCAGGGCTG TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA CCTTTA
ACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTTTT TTTTTTTAGT TTAAAAATTT A
TAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTTTT CTTTTATTCA AGAAAAT
GCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT GA
TATGGGGA GAGTAGTGTA ATTGTGTTTA CCTCAAAACT GTTCAAATTA TATGAACAAA CACAGCAA
AC TTAGGTACCA CAACAAATTT CTTGTTACTT TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCT
TCCAACC AGGATGAGAA CCATTCACAA AGCTATATTT CAAATTTAAG TACTAGAATA CATTACAAA
T TTTAAAACCC TAATGCTGCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTTA
AACTTG AATTCGTTGA AATCAAATAA CATTTAAAAT TCAGTTCCTC AGTGTCACCA GCCACATTTC
AAGTACTCAA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TTTCC
ATTAT CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT
CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC TACACG
GCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCACT C
ATTTCTACT GCAACGTCTT GTTACCACCT AGATGAGGTG AGTACATGTT CCTCGCAGGG ACACAGA
ATT ACAGTTTATT GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGTTC AC
ACTATTAT TATCCTCATT TTACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG TCAAGGTG
CC AAAATAAATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGACTT CATAGTCTCA GCT
CACGATC ACCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCA
G CTAGGACGTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGC
TCACAC TTGAGTCCAC TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACACAT
TCACCGTGGC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGA
GGACT ATTACTGTGC TTATACTGAG TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACAGAGACAT
CAGCAGTCCT ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG AGTTTC
AGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAAT T
TACTTCTTC ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG TAATTAAAAT ATGTATT
GTG TGTGTGCATT TTTATATGTA AAGAACTACA TATTTGCCTA CAGTATTTAT ATATATTTTA TA
TATATACA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAATGC
TG TAGGCTATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT ATA
TATATAC ATATCCACAT ATTCTTGCCC ACATTCACAC AAAACAGCAA AAGAGAGAAA CTTTAGCAG
T TAAACAGAAT CTTTTGGAAC ATAAAATGAC CACAATAGAG AGCAGTTTTT GCATGCTGTA AATT
TGCCAA GATGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT
AGGGCAAGCT TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC TTTTTCTCTC TTGAT
GTAGA TCTCCACGCA GTCCTCATCT TTTTGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTTGG
CTTCTTCTGT CAGAGGTTTC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACTTTTCTGA TTCCAA
TCCA GTAATAACTT GGTGAATAGC TCAATATGGA GTTTAGGTAC TCAATCTCTT CTTTGTTTTG A
ATTGCAACC AGGTGTGTGT ACCTTTGCTG ACAATAAGCA CTGGCCTCAT CATAAGTCAT AGCTTCC
GTG GAGGTGTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA GCACTAGTGG GAGAAAAAGA AA
AGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT GACAACTGTG CTTTTTATTG TCTTATTT
TT GGCAATGTTT GTGACATGGC CCAGACTTTT CTCATCTTTT CAAAAGTAAG AAGTACGTAT GAA
GAAACAG CGACTTATTG TTTATCTCTT TTGTGACTGC CACCCACTAG GTACCTTATC CACACTCAC
T CACAACATTA TAGTATACCC ATTTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAG
CACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC TTTCCATGAA CCATGCTATT GAATCCTCAC
AATGCATCTG GGAAATAGGT CATTATGATC CACACTTTAC ACTTAAGGAA AGGGAGACAC CAAGA
GGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGCCA
GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG TGCGAG
AATG AGAAATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG C
AATCATGAC TTCAAGAGTT CTTTTCACCC AAAGGTTTAG GCTTGAAATA CTTTCCTGGG GAGATAA
AAC ACAAAATGAA TTAAAGAAGG AAATCGTGGG TAGCTAGTTA CATTATTCTA CCATGATGTT TA
AGGCAGCA TCCTAAGATT TTGGGCAAAG GACACTAGTG CAATAATCTT TATTTCAGAG TTTAATCA
AA TAAATAAACA AATTTTAAGA CTTTCATTAT TTAGGTCAAA GAGAAAAGAC AGGTTTTAGC TAC
AATACAA TAAGAGCTTG TACAGATGTG GTTTTTATTA GAAGGCCTTT TGCATATCTG TGTTTCATG
G CCCGAGGCTG CCCTTATAAA GCGTTCTGCA CTTACCGTTT TGGGAAGCAG TTGTTCAAAC ACAG
GATCTC TCAGGTGGGT ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC
AGCCAAGAAC AGCTGAACAC TACTTCGGCT GAGGCCCTTT TATAGGAGGG ATTGCTTCCT GTGAA
TAATA GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTTTCCC
GGGAATATCC ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC TTGAAGCTAC TTCACC
TTTG TCCATGCCTT TATATCGTAT ATGCAATTTT ATTAATATGA CAAAAATGCA TGATTTTTAA T
TATAATAAC ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG TTAGTAGTGT CTCTCAT
GTA GTTGTGGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC AAGAATAGGT TTGTCATCCA TA
GTCTACTA CCTTCAATTT CTCATTCATA GCTGTGGATA ACCAATCACT ACTCATTTTT TCTTCCTT
TT TCACCTGCCA ATTCAACATA TTTAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGA
TATTAAT CTTCAGATTT TGCACGGCAG TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATATCTA
A CACTCAAATG GTTAAAATAA TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT ACAT
CTGGGA AAGTTTCATG GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC
CTGTAATCCC ACCACTTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GACCA
GCCTG ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC
ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG TGGAGG
TTGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTAA A
AAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTTAAT
TGG TCAAAATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA AGAATAAAAA TTCTTCCACA AT
GTTAACAG TGACTAACTC TGGATGGCAG GATTTGGGAT AATTTTTATA TCCTTCATTA TTATTTTC
AG GATTTTAAAG TTTTTTTCAA TTTCCCTTTT TTTCACCTTT ATAGTAACAA GAATACAGTT TAA
AGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAG
G TGGGTGGATC ACCTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTC
TACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC
CTGATGCAAG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTG
CACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG
AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCTTCA
TTTT GACATTTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG A
TGGTAACAG TAAATGGGGA TCATTTTAAT TTCCATATTC TGTAGGTTTT CAGAGCTCAA GTCAAGC
TAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CC
TGAACGAG TAGTGGTAAA AGCCTCGTTT TTCTCTTTAC TTGTTAGCAC TGGTCTTTCT GTGTTCAT
AA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATTCCAAA AAAGACAACT GAT
TAGAAAA AAATAACTTA ATTAACGAAT TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATTCCC
T CCACCTTACC ACTCTCTTAC ATGATCCAGA TACTGACATT ATTCCAATTC TTTATCCCAC TTTA
CTTAGC TCAATGTGGT TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTATTTA
GATTTTAGGG CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTTTTAA TAAAG
TATGA ATACATAATC TGCTATTTTT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA
AAACAATTTA TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG TCGTTA
ACAT CCCTAGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA GTTTATCTCT T
CCCCTTTTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTTTC TATTTTA
CTT ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TTTATTGAGT GCTTACTATG TG
CCAGGCCA TATTCTGAGC ATTTTGTATG TTCACCTATT GATTATTCAA TCCGTACAAC AGCCTATG
AA ATAGGTACTC CTATTATCCC CATTTTACAG ATGAGGAAAT TGAGAATCTG GGGATTTTAT CTC
ATTCAAA AGCACAGAGC TAAGGGTTGA AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTACCTG
C TACTCCAAAC CATGATTTCT TTTGTTGTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT TCCT
GTACTC TTCTTGCCCT CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG
TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGA
TGCAG TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC
AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA GTTCCT
GATT CAAAAGCAAA TTTTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT CTAAACTGAT T
ATTTCTAAA TTGAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTG
GAA GAGATAGGTG AGTAACAGTA ACTTAAATGT AGACTATATA TAATATATAA TATATGTAGA GT
ATATATAT ATAATTACAA TATATTATAT ATGTGGAATA TATATATTAT TTATATATAT TTATATAT
TT TATATATATA GATATTTTTA TATTTTATAT ATAAATATAG ATATTTTTAT ATTTTATATA TAA
ATATAGA TATTTTTATA TATATTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATC
T TGAGACCTCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACT
GCCTTC CTTTTGTTCC CAAATACCTG TAATTTCACA TGCTTACTTT ATCTTATATA AAATGTAGAT
GTACTGAGCA TGAGATCCAT GCATAATTTC CCTCTAGTCC CTTCTTTTTA CATGTAAAGT GTAGA
CTCAC TGAGTGTTAC AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTTCG
TTTATTTTCT TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCTTTG
GAAA AAGCGCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC AAAATAAACC T
CTAATCTGT TGAGATATGC TTCAGTTACT TTTTGGTTTA CAATATGTAC ATGTATGTAT ATAATTT
ATA TGTATATAAT ATATGTACTT GTTTTAACCA GAGGTATGTT ATTCAAAATC CATTCATCCT TA
CAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC TGCCCCCGAG GTTGTCACTG CAAATCAG
GT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGA
CAGACCC AGCTTTCCTC TCGTGGAGAG GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCA
G ACTATAGCTT CTTCACCTGC TTTTTCCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT TTTG
AGGGTG GGGGCAAATC AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTTGAATAGT TGGGCATGTT
GAATATTATG AATATCATCT CCCTCTTCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGAT
TAGAG GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT
TGCCGGTTTT CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG CATCCG
CTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG C
CACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT CTCTTCCTGG AAGTCTC
TTG TCCTCTCCTC CACACCCTTT AATCAGGCAT CAAAGACTTT AACCAGTTTT GCTGTGTGCC CA
GGCCCACT CATTCTCACT TTTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGA
TT GGGGACCCCA AGACAAATGT TAGAATTTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGG
GTTTAGT GGAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTA
T ATTTGGTGAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGT
TCCCTT ACCTCTGCGA AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCCTCT
CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AGGGA
GGAAA TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTTCTT GCATTCCCAA
AATTGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA CCTAAA
TATA TTTGATGAAA ATGTGTCTGG TTCTAAGTTT ATTTCCCAGA AAGCCATGTT TACTCACTTG G
AATTTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTTTCTC
CCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA AGAGGAATCA CCTGGACAAC TC
ACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCC
AA GAATTTGGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA GAT
CCTATCA CACTTAGATG TATTGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGT
G GTTGGTGCTC AGCTATAGGT ACCAGAATTT TGATCAAAAT TTACTATCAT TGTGACACTT CTCT
TCGGAA CTGGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA
GTAGCATTTT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAG
CAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTTTTCTCCT
CTGATTCCAG AGGACTTTGT AATTCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG ACTTGA
ATTT TTCATGTGCT TTTTGCTTCC TATTTGGCAG CATCTTATCT TGAAGTTTCC GCTTTCTGCT T
GGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAAAGC
GGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT TTCCTGAATG TAGCCAGACT GT
TTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT GGATTTTAGA AGAGCCCCTT GTTTGTTT
TC CTTGGCCATT TGTGCTGCTT GTTTTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC TTT
GTTCTCA CGTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTTGGATTTT ACTGTATTA
G AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTTT
TTTTCT TCCCCAAATC TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTAGAT
CTCTTTAGAG CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGA
TTAAC CGGATAACAA TGAATATTTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTGTA
ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGG
CCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT GGTGCAAGAC T
GTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTGCAG
TGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA GCGAAATTCC ATCTCAATAA AT
AAATAAAT AAATACAGTG ATTTAACACA AGAGATTTCT ATTTCACACT AATGAGCTCT GTCACTGG
GG CAAGCTTCTT TGCCTCATTA AGTCTCAGAT TTCCCGAGAG CTTATTTATT TATACCAAGA GTG
CTTTACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACT
A ATTTATATCA AAGCGTTCTT CGTTTTTCCT TGCTGTGAAG TTTTTAGCTA ATAATTCATA AGAA
TATACC ATATTTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT
TTTACAAAGT GAAAGGTAGA TATTAATCTC ATTTTATGGA GGACAAGATA GAGATCTGGA GAGGT
TACAT AACTTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC
TAAAGTCCGT GTCCTTTTTA TTGGCTCCAT GCCTACTCAG ATTTAAATCT CAGCAGGGAA GTAAAC
CTTA GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC CATCCCAGTT T
CACGAGCTT AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCA
GTC ATTTATTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AA
GGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT ACCGCTGTGG GCAGCCATGG GGCTCAGC
TG CACTAACAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCT
GCCTAGG GTATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAAT
T CCTCTGCACT TTCAAGTGGA TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCT
TGTATT TAAATCTGAC ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTTTCTGTC
ATTACTGTAA CAGATTACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTT
TGTGT GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTTTCAC ATTGCCAATA
TCAAGGTGTC ATCCAGTTGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTTCAAGC TCATTC
AGAT TGTTGGCAGA ATCCAGTTCC TTGTGGTTGC AGGACCAAGG TCCCTGTTGC CTTGCTGGCT G
TTGGCCAGG AGTCATTCTT AGCTTCTAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC ACTTCAC
CTT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTTCAAATG TCTCCAACTG TGCCTTCACC TC
ATTTCTCC TCTGTGTACC ATGTCTGCCT CTACTGCTTG TAAGGGCTCA TGGGATTACA TTGGATTT
AT TCAATCCAGG ATAATCTCCA TATTTTAAGG CTAGCTGACT AGTGATCTTA ATTCCATCTA CAA
AGTCCCT TCCAATAGTA CTGTATTAGT CCATTTTCAT GCTACTGATA AAGACATACC CAAGACTGG
G CAATTCACAA AAGAAAGAGG TTTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC ACAA
TCATGG CAGAAGTCAA GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGAGAG
CTTGTGCAGG GAACTCCTCT TTTTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CAAGA
ACAGC ATGGGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA
GGAATTCAAG ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA TGTTTG
ATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC TGCCCACCAA G
GCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTTT GGGAGGCCAA GGTGGGTGGA TCATGAG
GTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCATTT CTACTAAAAA TACAAAAATT AG
CCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCACTTGA
AC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA TTGCGCCGCT GCACTCCAGC CTGGGAGACA GAG
CAAGACT GTCTCAAAAA AAAAGAATTC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCA
G GAATTAGGTG AATGGCTAAC CTAAATTAGC ACTGTGATGT GTTTTCTGAC TTGGTCCTTA TAGC
TCCTCT GCTTAGATGT GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTTA AGTGGGAGTT
AAATATCCAA AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TTTCT
TGGAT AACCCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTCCC
ATAAATAGAC ATTTCATTTT GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC AGTTAT
CATT AATTGGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG TCATTTGATC A
TCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA GGCACTGAGG GTTAGAG
TTT AAATAACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT CC
ATCTGACT CCAAAGTCTA TGTTCTTGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGTTTTA
CT ACTATATTCA CACTCTACTA ACTTTACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA CAC
AGCACAG AAAACACATG AATGCAAAAT AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAATAC
C TGATGTTTGC TCTAATCCAG TTTTACTATT AATTAGTTGC TGGTGCCCAA GTTTTTACTG AGAA
ATGGGG ATAATTTTGG AAGTCATAAT GATGCCTTCT TCTCATAGGG TATTTTATTT GTTGTTGTAT
CTCCAGGCCC CAACACAGCC TGGCTTTTAG TAAATGATCA AAAATACCTG TTGAATGAAT AAATG
GAGTC ACCTGAAACA TGTTAAACAT TTGTTCATGT GTCCTAATCG TGGATTTCAG GATAGTAAGC
ATCCTAAAAG GAAAGCATGC ACACTGTTCT TGCTACATTA ATTTCTCACA ATATAAAAAA AGAAAA
GCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGAA G
CTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA GTCCTGGGGG TCAGACC
CGA GGAGAGCAGG AAGTGTCTTT TGAGGGATAC ATTTCCACAG TGGAAATAAT GAGACTTAAA TA
AATATTAT ATACACAGTT CAACTGTTTT TATGTGTAAA GGTAGTAGGT TTTCACAGTA AGGAAGCA
CT TCTTTTTTTT TTTGTTTGAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCT
ATCTCGG CTCACTGCAA TCTCTGCCTC CTGGATTCAA GTGATTCTCC TGCCTCAGCC TCCCGAGTA
G CTGGGACAAC AGGTGTGTGC CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC GGTT
TCACCA TGTTGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGTT CTGCCCGCCT CTGCCTCCCA
ATGTGCTGGG ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TACAA
ACCCT TCTTAGAATA TTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTTCCCAA CTAATACTAG
GAGGTTATAA CCTTCATACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGCCAC
CTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC G
GCATGGCCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATAAAG
GAG TCAAGGTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT GTTACACAGG TTGAAAAGCT AA
GGTTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCAT
TG TCCAGAAAGG AACTGTGGAA GATTTTGGGC TGAATTTCAA AACAGAATTT CCTCACTCTC TGG
ATGTTGG CTTACTTGGC CTTTGATGTT CAGAGGTGGT GCCTTTGTGT TGTTGAACAA TGTTGATTT
T GGAGAGAAAA CAGAGTTGAA AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC AGAG
GATAAT TTCAGCAAGC CAGCAAGGCC TCATCTCTGC TTCTAATAGA TAGGAAGAAA GGAAGAGAGG
AACAATACTT TTTTAAGAAG CTCAGCTTTA TCGCCTTATC TCATAGAAAG ATGCCTCCAG TCTGT
CTGGC TAAAGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGTTTCCCT
TCATTAAGAG AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC TGTAAC
CCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCACTTGC C
TCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT TCTTAGTCTA ATAGACT
AAG GGTCTCTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GT
AGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TATTGCTGCT AACTAGCTAT GTGACCTT
AA GCAAGGTATT AACTCTCTCT GAATTTCAGG TTCTTCATCT GTTAAATAGC ATATCTGTAA AAT
GGGAATT ATTTTCATAT CATAATGCTG TAGCTTTAAA AAATAAAATA AAATGGATGA GATAATCAG
A ATTAAAGAGC CTGGGATATA TAGTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTA
ATTTTA CAGTTAACCA TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATTTG
CCTGTCCTTC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCAT
CTGGA TGGGTGGGAA ATTTCTAGGC TAGTATTGAG AAGCCCATTT CTTGGGAAAT AGGTCCTGGA
CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAG
AGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTTTA CCTTCTTGTG AAATGGATTC A
AAGATTCAA AGACCTTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG CTGTATGTTC CATGGAA
CAC TACTTCCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTT TGGAAACACT CC
ATTATGTG GCCACCTCCT TGAAGACTCT AATGCACATT AGCATGTTAA ACAGTCTTGA GAAGTCCT
GC AGAGCAGAAA TTGCTTCACA TCTGCTAAGC CGGCAGTTTC CCAATATACT TGATTATGGA TAG
TTTTTTC CTTACAACAC CATTCTCTGA TATGCTTCCA ATGACATGAA ATAAATATAT ATGCATGAG
G TTCTTCATTA GGGCATACTT TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGC
ATTTAC CTTTTCTGCA TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGTTT GGTTCCCACA
ATATCTCCAA AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTT TTTGG
TTTCC CAATGTATAT CAAAGTTACA TTTTTACTAT ACCATAGTCT ATTATATATA CAATAGCATT
ATATCTAAAA AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATTTTCTACC CAGACC
ACTA AAACTTTCTT CATATCAGCA ATAAGGCTGT TTCACTTTCT TACTATTTTT TGTGATAGCA C
TTTTCCTTT CCTTCAAGAA TTTTTCCTTT CTATTCACAA TTTGTTTGAT ACAAGAGGAC TAGATTT
TAG CTTATCTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT GCTAATGATC ATCTGAGACT TC
AGCAAGTC ATAATCTTTT GCTGGTGGAA GGTCTTGCCT CAGTGTTGAT GTCTGCTGAC TGGGTGGC
TT TGGCAATTTC TTAAAGTAAG ACAACAATCA AGTTTGACAT ATCAATTGAC CCTTCCTGTC ATA
AATGATT TTTTTTTTCT CTGTAGCCTG CAATGCTCTT TGATAGCATT TTACCCACAG TAGAATTTT
C AAAATTGGAG TCAATCCTTT CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA TTAG
AAATCC CTTGTTGTCA TTTCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA
AACCACTTTC TTTGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TTTATCCTGA GATTG
CAACA ATTCAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTCAT
TTGTGCTTAC TTTCTCCGCT GAAGTCTTGA ACCCCTTAAA GTCACTCATG AGGGTTGGAA TCAACT
TCTT ACAAACTCCT GTTGATGTTG ATATTTTGAC CTGCTCCCAT GATTCATGGG TATTCTTAAT G
GCATCTAGA ATGGTGAACG TTTTCAGAAG GTTTTCAGTT GGCTTTGCCC GGATCCATCA GACGAAT
CCC TATCTATGGA AGCTATAGAT TTATAAAATG TATTTCTTTT TTTGTGGGGG CATAGCGTCT CA
CCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCT
CA AGTGATTCTT CCACCTTGGC CTCCCAAAAC ACTGGATTAC AAGCTTGAGC CACTGTGTCT AGC
CCAAAAT GTATATCATA ACTAATGAGG CTTGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTACAG
A ATGGACGCTG GGTTACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTC
CTGGGT GAGCAGGCCC ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTTTTT TCTGAGCAGT
AGATCTCCAC AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAA
GCTCT GTTTTTCCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA TAATTCTCTA GGGCCTTAGG
ATTTTTGGAA TGGCAAATTG AGCATTGGCT TCAACTTTTT TTTTTTTTTT TTTTTTTGAG ACAGAG
TCTT GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC C
TAGGTTCAC ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATG
CCC GGCTAATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA TGTTAGCCAG GATGGTCTCG AT
CTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAG
CG CCCAGCCTGT CTTCAACTTA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGT
CCTTTCA AGCTTTGAAG CCAGGCATCA TTCTCTTCTC TAGCTATGAA AATCTTAGAT AGCATCTTC
T CCCAATAGGA AGCCATTTTT TATGCCCTAA AAATCTGTCG TTTGGTGTAG CCACCTTCAT CATT
GATCTT ACCTAGATCC GCTGGATAAC TTACCACAGT GTCTACATCA TTACTTCTGC TTCACCTTGC
ACTTTTATGT TATGGGGATG GCTCCTTTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACA
TTCTT CTTTTACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATGTT GGGCCTTGGA
TTACACTTTG GTTTAAGGGA ATGCTGTGGC TGGTTTGATT TTCTATCCAG AACACTAAAA CTTTCT
TCAT ATCAGCAATA AGACTGTTTC ACTTTCTTAC TATTTTTTGT GATAGCACTT TTCCTTTCCT T
CAAGAATTT TTCCTTTCTA TTCACAATTT GACCGTTTGA TATGAGAGGC CTAGATTTTA GCCAATC
TCA GTTTACACCA TGCCTTTTTC ACTAAGCTTC ATCATTTTAG CTTTTTATTT AAAGTAAGAT GT
GTGACCCT TCCTTTCATT TGAACACTTA CATGATGATG CCTGGCTTCA AAGCTTGAAA GGACAGGC
AG ACTCTCTTAT TAGGGGCTAA CACAGCTGGC GACTTTTAAG TTGAAGCCAA TGCTCAATTT GCC
ATTAGAA GCCATTGTAG GGTTAATTAA TTTGCCTAAT TTTAATATTA TGGTGTCTCA GGGAATAAG
G AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT TATC
AATTAA GTTTATCACC TTGAGGGCAC AGGTCATGAT ACTTCAAAAC AATTACAATA ATAAAATAAA
AAATCATTGA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TGAGA
ATTAC CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGA
CTTACTTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA GTACCA
TAAA AACAAGGTAT ACCTGTTTAT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCACT C
CCTAGCTCG GAGACATTCT AACCAACATA CACTTACCTT TCTTTTTGCT GTGTACAGAA TTCAAAT
CCC TGTCTCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA TG
TTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG TGTTGCTATA AGCATTAGTT CTTCTCCA
AA GAAAATAGTC CACTTGGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATTTT TTA
CAAGAAG ATTCAGTCTC TTACCTACAT AAGCAAAAAT ATGAGATGTT CTCTTATCAT TTTTCCATC
T ATCTTATAAT CTTTGGTGCT GACTTAGACA CTCATTTTCC TTTTTGTACG TGACCATGTA AAAG
TTCAAG TCAAGAAAAA CTTGTTTTGA CATTTGTTTT GCTGAGTGAT GGGTCCCTAA AAGAAATTTG
GCTTTGCTTT TGAAAAGTTC AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AGAAC
AGTTG TGATGTGTTT AGGTGTTTTA AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA
AATGAAAGAA TATGAAGGAA AGCCTTCTTG TCTTAGAACA CACTGATTCA CAAATAAGCA GCTTCT
CTCA AAATGTTGTA ATTACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATGT C
TAGAAACTT AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT ATATATATAC AAATTGT
GGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACTGTTTAA AAGGGAGGGT AT
CCTTGAAA GCTTGACACT TGACTCTTTT GACGAGGCTG AGGGAAAACA CTCAGTTTCA TAGATTGC
TG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAATT TGGCAATATC TAGCAAAAGT GCT
TATGCAT TTATTCTTTG ACCTAGTAAT CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAA
T AAAAATATAT ATACATTAGG TTATTAGTTA TGGTTTAATT TTTAATAGCA AAATATTTAA AACA
ACCTAC ATGAACAAAT AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATT
CACTTATGTT GTTAATTTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TTAGT
ATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAGGA
TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG AATTAG
GCTT CTTTGAGTAT ATGTTTATAT ATAGTTTTGA CTTTTGAATT ATGTTTATGT TTACATAGTC A
AAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CTTTAAAATT TAATACA
AAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TA
ATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT ACATTCAGTG GTTATAGTCT AAGGACAA
GA AAAATTGCAA AAATATCTTG AACTTTAGCT TGTAGGATTT TTATTGGTAG CAATACTAAT GTA
CTAATTC TGAAATTAAT GTTCGTGTAT TATAGAATTG AGTAAATGAA TAAATATGTT GATGTTATT
G GGAACTAAAA TTATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTTGG CAAATGAAAC AAAG
ACCTGC AGAGAGATAA CCATATAAAC TCATTATTTT AAAAATTATA AGTGTCCTAG CTCTGTTACT
GAAAAGGCCT AGATTCAATC TTATCTTGAT AGACAGGAGG GCACCCCTTT CTCAGAACAT GGTTT
CCAAA TGCCATTCTC CATTAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCTGG
ATTAGGTAAA GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA AGAAAGTGCT CAAAAA
CATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA TTTAGGACAA T
CGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT AAAACAAAAA ATAATCC
ATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC TTATTTACAG ATGAATATCA AATAGCAAAG AC
AGAAGAAA TGACAGAATT AGAGAAACAT CATTTTGCAA AACACCACTG TAATAATCAA TTCAGGCA
AG TATTATTAAT GGATGTATTA CTATTGCGTA AAACCAGTTG GGGAACAGGA TATTCATACA GTC
TGAAGGT GTCACCCTAA ACATAACTTA TTACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCT
A GCAGAAACCA TCTTAATCTA GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG TCAT
GTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTATTCTT TTGTATTCAA
CAGACCACCC AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTAATT CATTT
TGGAT TTTAAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATCTTTT
ATTCAATACT TTAGCTTGGA GAACCATTCA GAGTTTCTAA CTCATTGTAT TGCCAAAAAT AGAAAA
CAGC ATGGTTTCTT TTGAAAATGT CTAACTTTAA AGTTACTTGT GTGTGTCACT CAGATTCACA T
AGCTTTTTT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TTTACAATCT TTTATTT
AAT ATGACTCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC AA
AGCATAGC AATTTGATTT GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATTACA GGAATCAT
TT ATGAAGCAAA CACTAAAATA TTTATTGTGA AGATTATGAG AACATAGAAG ACAGTTATGA GAG
TAAATTT GAAAACCTGA ACACAAAACT TACATATACT CCAATTGTAA CTTATAAAAA ATACGTGCA
T ATAAGGATAA AACAGTACAA ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC CTTT
TGCTGT CTTAATTTTT TCCTTTTACA TTTTGATACA TTATTTTAAT TTTAATTTTA AAATTCAAAA
GAATTTGCCA CTCATCTTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA TTATTCTGTT CTTAG
TATAG TTTTGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATAAG
ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC ATTATG
GACT TTTTTTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT G
GCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG CAGACAGTTA GCTGAGA
ATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC ACCTTTCCAC CCACGTTTCC CT
GTTCTGTT GTACTCTGCT TACCCTTTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TTGCTCTT
AG TCATTCACTA TGTTGTTTAA TCTGCCTTCC ATCTTTCTTA TCAGTTCAAA TTAGAATGTA GAC
CTGAATT TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTC
A GAGAACATTC TTCATTTGTA GAATGGGAAG ATTAATCTAT ATTCCACTTG GATGGCAAGT CTTT
TATAAA CTTTATAACC TAAACATGTG TGAGTTGCTA GTATCATTAT GTTGGTAAAG TTATTCTGAG
ATATGATAAC AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTT AGAGAGTGTG GAATT
AAAAG GCTTTATCCT CAAATATGAC TTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAACAA
ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TTTTGTTTAG TCTTTGACAT CCACAT
GGTT AAATCATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT GAAAAGACTT A
TTGAGGAAT AGAAGACTAC ACATTTTTCA GCAAACACTG CACGTTTTGC AGAATTTCCC CAGGCAC
CAG TCTCCAGGAA TTTATTGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TG
GAGATCTT GCAAGTTTTG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGTTGTG AAATATTA
GT ACAAGTAAAA ATTATTTACA ATGAAAGACA TTTTGTCAAT AGCTATGAGA ATTTTACCAT TGA
CCCAGAA ATTCCATTTC TTTCTTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TATTCATTA
C AGTATCGTTT TTCATAGGAA AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAG
GTCATA GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATGTTT TTAAATTAAC TTGGCTTGGG
TCTTCAGCAA AATTGGCTTC TTAACATTGC ACTCCAGAGT TAGACTTACC CACTCAGTCA CTTAT
CATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG
CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT GAACTC
TGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA TCATAATAAC A
CAACGGCTT TGTTTTGTTT TTGTTTTTGT TTTTTGACAC GGAGTTTTGC TCTTGTTGTC CAGGCTG
GAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC TGGGTTCAAG TGATTCTCCT GC
CTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAATTTTG TATTTTTA
GT AGAGACGAGG TTTCTCCACG TTGGCCAGGC TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACC
CGTCTTG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTT
T TGTTTACATC TCTAGTGCAG CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTTCAT CTTT
TTATTT TATACAGCAA TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA
AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGAT
ATTGA CATCATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTTTTG GAATATAGAA
AATCTGGATT ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG TTCCAC
ATGT TTCTGAGGCT GTTTGTCCTT ACTTTCTTTT CTGTTTTATC CACTCTTTCT GTTCTTTAGA T
TGGATCATT CCTATTGAGC TGACATCAAG TTAACTGACC TTTTATTTTG TCCAAACTGC TGTTAAA
TGC ATCCAGTGAA TTTTTAACTT TATATAGTAT ATCTTTTAGT CCTAGAATTT CCACATGAGT TT
TTTAAGTT TCCATTTCTC TGCTGAGATC TCCTATTTGT TCATTCATTA TGACCATATT TTTCTCTA
CA TTATTGAGCA TAATTATAAC AGCTCTTCTA AAATTCTTGT CTGCACATTC TAACACCTGA ATT
ATTCTGG GGTCAGTCTC TGTTACATTG CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTGTTT
C TTAATATGCA AAATGATTTT TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA TTCT
GGATTC TCGAGAGAGT ATTGACTTGT TTTTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAACTCC
AAACTCTAGG TCCTCTGTAA TGGGCAACTG CAGTAATCTT TGTTTAGTTC TTTAAGACTT ATTGG
CCAGG CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG
AGGTCAGGAG TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAAAAA
TTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAATC A
CTTGAACCT GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT ACTCCAGCCT GGGTGAC
AAA AGCGAGACTC CCTCTCAAAA AAAAATTTAT TGGCACTGCT TGGCATCTGC TATGAATACA TG
AAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC ACAGAATTTG GGTCTCCCTT TCTCTGGA
TT TCTCCTTTTC TGGATTTCTT TTCTCATTTT CCAGCAGCTG TGGTTGCCCT AAACTCGGTC CTC
TGTTTCT TTACGGCAGT AAGATTTGGG AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAAAAA
A TAATTTTCAT CTTGATGCTA CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT TGCT
TTTTAT TGCTCTCCAG AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC
TACTCCCCCA AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC TTCTT
TGGAA AAGGATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG TTTTTCTCAT CCGTAATCTT
TTTATTTTCA TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT CAAATG
ACCC CCATATTACT AAATACAATA TCCCCAACTG CATTTATAAA AAGAAAATTT ACTGTTTATT A
GTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT TAGAATC
CCA GATTCTAACT TACTAGCTGG TGTATTAGTC CTTTCTCATG CTGCTAATAA AGACATACCC CA
GACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATTGACTCA CAGTTCAGCA TGGCTGGG
GA GGCCTTAGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA AGC
CCCTTAT AAAACCATCT GATCTTATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACT
G CCCTCACGTT TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATA
ATTCAA GATGAGATTT GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA
TCTCATGTCC TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCA
TTCCA GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTGCC
TATGAGCCTA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC GTTGGG
TAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAGT C
CAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC TTTGACTTCA TGTCTCA
CAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GC
TTTGCAGG GTATAGCCTG CTTCCTGTTT GCTTTTTCAC AGGCTGACAT TGAGTGTCTG TGGCTTTT
CC ATGAGTATGG TGCAAGCTGT TGGTGGATTT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCT
CATGCCT GTAATCCCAG CACTTTGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACC
A TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGT
GGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT
GGAGCTTGCA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCAT
CAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG
CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC CCTAGT
AGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA GGCATTTCCA T
ACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTCTTGA CTCCTGTGCA CCCACAG
GCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG AACCCTCTGA AGCAATGGCC TG
AGCTGTAC GTTGACACCT TTTAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCTTCAT
AA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA ACCATTTTTC CATCCTAGGC CTCCAGGCCT GTG
ATGGGAA GGGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTTT TCCCCATTGT CTTGGTAAC
T AACATTCAGC TCCGTGTGCA GCACCAACTT ACTTATGCAA ATTTCTGTCA CTGGTTTGAA TTTC
TCCCCA GAAAACAGGA TTTTTCTTTT CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTTATGC
TATGCTTCCT GTTGAAGACT TTGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TCTCT
CTCAA GTTCAAAGTT CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAAGA
GTGACCTTTA CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG GACTTA
GTTG TCCATGTTAC TATCAACATT TTGGTCAAAG CCATTCAACA AGTCTCTATG AAGTTTCAAA C
TTCCCCATG TTTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT CTGTCTGTTA CCCAGTT
CTA AAGTCACTTC TACATTTTTG GGTATCTTTA CAGCAGTGGC ACTCCCCATG GTACTAATTT AC
TGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACTTAC TCGAGACTGG GTAATTTATA AAGAACAG
AG GTTCAACTGG CTCACAGTTC AGCATGGCTG GGAGGCCTCA GGAAACTTAC AAACATGGTG GCA
GCAAAGA GAAGTTCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTC
A CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC CCTC
CCATGA CAGGTGGGGA TTATGGGAAC TACAATTCAA GATGAGATTT GGGTGGGGAC ACAGCCATAC
CATGCCAGCT AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTTTCCTAT TTGTT
CAACA AAAATAATGA CACCCCTTTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGCCT
TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT GTAGAC
TTTA TTTTTTAGAG TTTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG TTTCCGTATA G
CACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTACATT
TAT TATAACTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA AAATCCATAG TTTATATTAG GG
ATGCCTCT TGGTGTTGTA CCTTCTATGG GTTTTGACAA ATGTATAATG ACATGTATTC ACCATTAC
AG TATCATAAAG AATAGTTTCA CTGTCCTAAA AATCTTTGAT CTTCTTCCTA TTCATCACTC CCT
CCCCATT AATCCCTGAC AACTACTGCT AATTTTCCTG TCTCCATTGT TTTGTCTTTT CCTGAATGT
C ATATAGTTTA AATATACAGT ATGTAGGATT TTCAAACTGG TTTATTTCAC TTAGTAATAT GCAT
TTGATG TTCTTCCATA TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TAATATTCCA
TTGTCTGGAT GTACTACAGT TTATGTATTC ATTCACCTAT CAAAGAACAC CTTGGTTGCT TCCAA
GTTTC AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTTTTTTTGT GAATTGAACA
TTTTCAGCTT TTTTAGCTCC ATTCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGTTTA
GTGT TGTAAGAAAC TGCCACGCTC TTCCTAACTG GATGTACTGT TTTGCATTCT CACCAGCAAT G
AAAGAGTTC CTGTTGCTCC ACATACTCAC CAGCATTTGG TGTCGTCAAT GTTTTGAGCA ATAGCAT
TTT GATCTAACTT TTCCTAGGTA TTCTTTTTGA AGGAAATAAT ATGACAGATA ATAGAGAAAG GA
TATACGAG GACAGTTCTG TCCTTTATTT ATAGTCCATC ATTTAATGAA GGACTCTGTC CACACTTG
GT ATTTTTAACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGTTGCT GGC
ACACATG GTTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TTTTTTTTTT TTTTTTTTT
T TTTTTTTGAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCA
CTGCAA GCTCCGCCTC CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC
AGGCGCCCGC CACCACGCCT GGCTAATTTT TTGTATTTTT AGTAGAGGCG GGGTTTCACT GTGTT
AGCCA GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA
TTACAGGCGT GAGCCACCGC GCCCGGCCTT TTTTTTTTTT TTTTTTTTTT TTTGAGATGG AGTCTG
TCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC CATCTTTCAG G
TTCAAGTGA TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATTACAGGT GCCCGCCACC ACACCCA
GCT ATTTTTTTGT ATTTTTAGTA GAGACGTAGT TTCACCATGT TGGCCAGGCT GGTCTCATTC CT
GACCTTGA GTGATCCACC TGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCATGGGT CATCACAT
GT GGCCTGAAGC ATGACTGTTG CTTTAATCAT ATGAAATACT GCTCTGTATT GTTATCTATT TGA
AATGCCA CACCTCCTGA GCTAAATTGC AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATATTAG
C ATGATACCAT GACACATATC AAAAGCTGTT ATATATTGTT ACGTGAATTG ATTCTTTCTC AGTT
AAGAGG ACCTCTGTAG TAGCACTTTC ATACCGTTAA TTTTTCATTT TGTGCCCAGC CCCTACTCTG
TGAAAAATGA AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTGTGGACAA TGTGT
GGCTC AAGAGAAAAT TCAGTCAGTA AATTTGTTCA GTGCACAAAC TCTTTATCAC CTCTCACTGT
TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCTTA CAAATTGTCT GGTATATAGT AGGCAC
TCAA TAAATGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT ATGGTAGACA G
ATCATTGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA TATGTTACAT TTCATGT
CAA AAGGGACTTT GCTAATGTGA TTAAGGATTC AGACCCTTGG ATTGTAAGAT TATCCCGGAT TA
ACCAGGGC CAATCTAATC ACATGAGACC TTAAAAAAGC AGAAAACATT TCCCAGCTGG GTTAGAGA
GA GATGAGACAG AGTAAAAAGG AAAGAGATTC AGGGCATGAA AATGACTCTA CCCACTGTTG CTG
GCTTTGA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTTAAGAAA TAGGAAAAA
G CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCA
CTCAAA TGAGCAAGGA AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC
TTGATTTTAG CCAGGTGAGA CCTGTTTCAG ACTTTTGACC TATGGAAATA TAAGATAATA AAGTT
TTATT GTATGCTGCT AAATTTGCGG TAGTTTATTA CTGAAGCAAT GGAAAGCCAA TACAGACAGA
ATATACAGAG AGAAAGAGAA TGAGTTCTTT CCTGATAATT TGTAAATATT TGGGTCTTCA CTGGAC
AAGC TTCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCTT T
CTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGGAAA
GAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TC
TTTCTCAT ATGTCCCAGG CTGACTCTTG TGAGTTGTTT TCCCTTGGAG GCTATCGATG ACAGTCAC
AG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACTTCCAA GGA
CTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTTCCT
G AATATATTCC CTATTGTTAG GAAGCCAGGT TGGCTTCCTT GCCTACAATT ATGCCAAGCA GTCA
CACTAT AGAGTCCCTA GGGACATGAT ATTAAGTGAT TCTTTTAACA CAAACAACTT AATAATCATT
TATACTAATA GCAAAACGGC CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGG
AAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCTG CCTCTGGATT
CCCCTTTTCC TTATATTACC TCTCAGCACT GGCAGGCCTT TATTTCAGGA TACAGTTTCA CAAGTA
TTAT GTCACGTCTC TGAGAATTAT GTTGGTAGAT ATTTGCTCCT CTGGCCAGAA AGACCTAGTT T
GGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGT
GAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG CT
TATCTCAC AAGGAACTTG ACAATTTTCT TCAAAAATCC TAGTAGCTAA GATTTCTTAG TAACAAAG
CC ACTAAGGCAC AATTATGATT AACTTGACCC TTAGGTGACT TTTAAGGACT ATTCTATAAA ATA
TTACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAATTGACAG TGTCCACAC
T GGTAAAATAA GTTGTTTCAT AAATACATTA GAATTCATTT GCACTTTCTA CACAGCCCCA AGTC
CAGAAC TTTCCCCAGA ATAGGTCTAT GTTTTGCAAT CTGCTACTCC ATACAGAGAT TTGAGTTCAC
TTGGCAATTT AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AACAT
TACTA TACTTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAAAT
CCTTATGTGA ATATGTAGAT AGTCACAATT GCTGGTTGAT GATGATCTGT CTTTTCCTGT ATTTGA
GAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG TGAGAGAGAG A
GAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTTAGGCAG TAAACACTTT CGTTAATAAA GACGGAA
AAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA CACTCTGAGT TC
CCGGATGT GAGACATCCA GGCGCATTTA TCCAAGAGGC AGTTGGAAGC AACGTTCCGG AGCTTAGG
AG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCATTCTG GAAAACTGTT TGG
CAGTTTC TTAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCCCAG
A TAAATGAAAA AAAAAAAAAG CATTTTTTTT ACACAAAAAC ATATACATGA AAGTTCATAG AAGT
GTTATT CATAAAAAAC TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG
TCTATCCATA CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAAC
ACAGA TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC
TGTACTATTT TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTAATG
GGTA CTGTGTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA A
AGAGCCTTG TGGTTGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGTGAT
AAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AG
CTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTTTCAA TATCAGACTA CAGTTATACA AAACATTG
TC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACATTTGGC ATATATTTTT GCAATTTCCT GTG
AATCCGT AATTATTTAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATG
A GTTTACCTAG TGGATAGCTT TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAA
GTATAA GCTCAGAGAA CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA
GGCAAGCAGT ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGC
TATTC ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCACTC
TCCAAGAGAG AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC ATGCTG
TGGC TTGCACCTTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT GAGCCCAGGA G
TTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGA
GCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TC
ATTTTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTTTGACCT AGCCTGAACT GTAGCAAA
AG TCATCAGATA TTTTTCCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAA
CTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAG
G CTCATTTAAA ACTCAACCCA AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAG
GAGCTT GAGTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT
CTCCCCATTC TTTGATAGGC ATACTTGCTG TTTTCTCACA GCCAAGGTAC AGAGGGGACT TAGAG
GAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT
TTATCAGTTT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTATT
TACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCTTGTG T
GTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAG
GTA TTTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG ATTGCTCTTG AT
AGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTTTC CCGGAGAG
AA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA GCC
TAAAGAT TTGCTAGGCA TTATAATCAC ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATATATT
G ATACAATGAA TGGTTATAGC AGCCTTATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTC
CTTCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA
ATAAATGGTT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AATGG
AAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG
GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA GGTATT
GTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG AGGGTGATTG A
TATGTTCAT TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATACAC
TTT TAAAATGTTC AGTTTACTGT ATATCTATTA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG GC
AGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATTTTGG AGTTTAGA
TT TTAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA TTATGAGTCC ACA
AAAACCA CCAGGAAGTC ATGTATGTTT ATACTTTTAA GTGAAGGATC AGTGGATTAT CAACTCCCT
A ATGCTTTGCC TCTCTATGAC TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC CCTT
GCTTAA ATGTAAGCCT TCTTTCCTCC TTTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC
TTAAACAGAA TGTACAGCAT ATTATTTGTA CAATTAAAAA TTTTTGGCCA GGTGTGATGA CTCAT
GCCTG TAATCCCAGC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG AGTTCGAGAC
CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGTGTG
GCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAGG T
GGAGGTTGC TGTGAGCAGA GATCAGACTA TTGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCGGTC
CCC AAAAAAAAAC ACATTTTTTT TTAATGTTTC CTCCTTGCCT GTAGGAAAAA GGCTCTGACT CC
TTAGCCTG GGCATCAGAG CTCTATCTAA ATGGACTTTA ACCTGATTTT GTGGCACTAA TTCCATTG
CA GTACTTGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT TTTTGGAATA ATGTCCTCTC TCC
ATCTTGT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTT
C AGCCCACAGA GATATTTAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA CATT
TACTTA TATATGATCT TGTGATATTT TTTGTTGACG TGTTTACTTT AATTTTCTTC CATAACCTAT
TCATTCAACA AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATAT
AGATT ATAGATATGT TTGAAATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT
ATATCTGTGA TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT CAGGAG
AGAT ACGTGGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC ATTAAAAAAA A
TTTTTTTTT TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCT
CAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG AT
TACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TATTTTCTTG TTCTTTTCCT CCTCAGTT
GT CTTCCCTGAA GAAAGGAATG CCTTTTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA TTT
TTGACCA ATTTAATTTA ATCAGATGTC TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGAT
T AGAGACCAAT TCCCAAACAT GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGA
GCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCTTTT
TATTTTTATT ACTCTATTAG TCACTACAAC TATTTTCTGA TTGCTATGGT GATAGATGGT TTAAA
ACAAG CCTTCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGGTA
TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT GAAGAC
TCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGTG G
ACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAG
TAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AG
TCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGA
TT GGCTTCTAAA ACCTATGTAG TATCTTGGAC CTTACCCTAA ATGTAATGAG AAGCTTCTAA AGA
ATCTTTC ATTTATTCAT TCATTGAACA AATATTTTGA GGCTTTCTGT GAAGAACATC ATTCTAAGT
A GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAG
AGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT GATTTCAGAC AATGGTACGT
ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCT
TTGCA TGGTTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC
GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTTTTG GACTGAATAG CAAATACAAA TGCCCT
TGGG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAGC A
CAGAGGAAA ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA GATAATATAG TCTCTTA
TAG GTCATAATAA GGCAACCAGA TTTTATTCCA AGAGGATTTA AAAATCACTG GAGGTTTTGC AC
TAGGGTGA GAGGTGTGAT TTGTATTTTT AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGTAGG
AG TAAACTAAGT TAGGGGCTAT TTCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG GAT
AGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTT TGGGGGTAGA GTCTATAATA GGTTTGGTT
T ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTTGTA CCTG
AGCAAC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTTTTG
CAAATTAATT TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC ATTGA
AAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCAAG
GCAGACAGAT CAGTTGAGCT CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCT
ACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CACTTGGGGG G
CTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGC
AAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AG
GAAATTAA TCTGATCATT GGCAAATGCA TAGTATTTAA AGCCAGGGGA GTAGATGAGA TACTCAAA
GT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATTTAG ATGGTTATAA GAG
GAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATG
A AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCA
GTCAAA TAATATAAGG ACAGAAAAGT GACCATTGGA TTTGGAAATA TGATGAGCAC TTTGAGTGGA
GTGTTGAGAC AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCT
GCAAG CACAGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA GACACAGAGT CTTAGCATGT
CTTGTCTTTC TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT TATTCTGCTT TTTGTA
CCTC TACATTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA TTCTTATCGC C
TGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGGATG
GAT GGAAGACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GA
AAGAAGAG TTTAGATTTT TATTCTTTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAGTCC
TT AGATAATTTA TGTAATTGTT CACTTAGGAT TTTTAAATGT GATCACTGAT ATTGGACATG TTC
CTAGTGA AGCATTTTTG GTGTTTCACT GGTTGAAGTT AATAACTGTA AAATTATTTC CCGTTCAGG
A CAGAAAAACA GAAAACTTGA AGCTCCTATT AGAAAGTTCA AGATTCTCTG GGGTTCTTAG GATT
TACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG
TGGAAAGACA ATTCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTTCCATA GGAATCAAAC AATAG
CTTTC AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC TTCCAACCTC ATGGCTGTTG
TACCTTACCT TTCGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAACTT ACCAAGGACT AACCAG
CCTC TGGGGAATTG CTGTATACTT AGCAAACTTA CAATGGACAT ATTTATAAGC CATAATGATA A
CTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCATTTGC AAATGAGTTC CCTTGCC
CAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATTAATCT TTGAAATCCT CCTTTTCCAT TT
TTTGTGTC TTCCTTTTCC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGAAAA
AA AAAGTGATTT GATAAACTGA TTTATATTGT GTCCAAATGT GATTGTATTT TCAAAGATAA CCT
AAGGGGA GAATGCTGTC TGGCCCAACA GCAGGCTCTC GACTTCATTT CAGACACTGT GGCCAATGG
C TGGGAAACAG GTATGAACAG TAGGTTTCTG AGTCCCCTGG AATTATTCCA TTTATGTAGC CACC
TCCATG ACAGGAAGCC TCCCTACTCT TACTTCCCAG TTTGTTCATT CATGGCACCA GGTTGCAGAT
TAAAATTTGC TCAGTGACCT TTTATCTAAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AAGGG
ACAAA TGCTCATGGT ATACTTTTAG GAGATTGTGG CTCTCTATTA ACAGTATTTA TTCAACAAAC
ATTTATTGAG CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TATTAT
TTCA TTTAATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT CAGAAGAAGA A
ACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC TAAGATACAG AACCAAG
AGT CAAAGACATG ATTTTAAACC AAAGCTTTTT CTGCTACTCC ACATTGCTTC CCTAGGTGAG AT
CTGAGGCA TTCCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGCTTAGGAA AAAAAAGG
GA AATGTCCTAA ATAAACAGCT TTCCTATTTA CCAGAAACCA CTAGTTTAAA AATATAATGG GAA
AAATCCT ATTCACTTTA ACAATGTTAA AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAACTTAAC
A CATTTGTAGG ATATGTAAAG AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC TTAC
ATGTAT GGGGAGATAG ACCATCTTAC TGGATTCTAA TATTTAATAG TCTAGGTGTT CCATTTCTCA
CCAAATTAAT GTATACATTT AATACAATGT CAAACGAAAT ATCTTAGGAA TTGCTTACAA ATTGT
CAGAT AATTACAAAG TTTACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC
TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAA
AATT CTATTATAAA GGTGTATTGA TGAAAACAAT TTAATACTAG TGTAGCAATA GGCAGCAAAG C
AATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT TTAAGGTATG ATAAACA
TGA CATAATTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCATTAG AG
GGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTCATCT TACATTAAAA TAAATTCC
AG ATGTATTACA TTTAAATTTT TTTAAAAAAA GAAACCACAA AATACTTGAA GAAAATATAA GTT
GTTATAT AGTCTTTTGA TGGGAATTTT TTTTTTTTTC AGAGACAGGG TCTTGCTCTG TCACCTAGC
C TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTCC
CAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTTATTT
TTTGTAGAGA CAGGGGTCTT GCTTTGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTCAAG CACCT
CAGCC TCCCAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATGAA
AAGCTTGTAA AATACTAATT TTTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT TAAAAA
GCAA ACACAAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC C
TTTACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAAAGC
AAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAGTTTAAC CTTATCAAAG AA
GTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTTTTCCC ACAAATAACC AAAATCTG
TA AGAATACTGA GCTGCGAATG TTTCAGAAAA AAAAAAAAAT CATACACCTA GTTCGGCATG TAA
TTAATAT AGATCAGAAC ACTTTAAAAA TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAATCC
C AGCACTTTGG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG ACCA
ACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA
ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CAGTG
AGCTG ACATTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA
TAATAAATAA AAATAAAATA TTTATATACT CTGACCCATC AATTTGTCCA GCATAATTAG GCATGT
GTAC AAGGGTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA AAAAATTGGG G
AAAATGCTT TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT ATAATCAATA GTATACA
GCT ATTATTTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACATT CTGTTAGGAT AC
GCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG TTTCACACCA CTGCTCCTTT GCTAATAA
CC TTCAATGGCT TTTAAAGAAG TAAAAAACAA AGGCAAAATT CCTTAGTCAG CCCTTAAGAC TCT
CTGTTAC TTAGCTCAAA CTACCCTTTT CAACAACACT GCCCTAACCA GGATGAGTTT TTTGCCCCC
C TGGAGTACAT TCAGCCTTTC CTTATCAAAC CTTCCTTTAA ATAAGTATCT TCTCCAGGAC CACT
TCACTT TCTTCCCCAA TTTAGCATTT TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC
CACTCAAACC CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATTT AGGTA
AAAAG GTTTTTACTG TTTATTACCT ACTCAATAAA AATTTTCTTT TTTTGAGACA AGGTCTTACT
CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCTT CTACCTCCCA GCTCAA
CAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA C
TTTTCATTT TTTATTTTTT GTGAGATGGA ATCTCACTAT GTTACCCAGG CTGGTCTGCT GATCTCA
ATT GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGATTACAG GCATGAGCCA CAATATCTGG CC
CCAGTAAG CTTTTAAGGC CATTAACATG AGGAACAGTG TTCTTTACAC TATTTTATCA GCTAGGGC
TT TGCATGGAGT AGGAGTTTAG TAAATGCGGT TGATGGGTTA ATCAATGTGT GAAAATATTC AGA
GCCACCA AAAACAGATA TTATGTCTAT TCTCATCAAC AATCAAAATT GAGTAAACAG CCATTTTCT
A ATACAGGAAA CCACAAAACA TTGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA CCAA
TTTTTT CATCCTGATC CAAGTTAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAATTTGA
GTAGAAGCAT TTCTTATGAA GGCTGTCTTG ACTGGATCAC ATTTTTATTG CTGTTGGAGG TGCCA
AATGT GTGTGTTTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT
ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCTTGCA CTAGGGAAAA GACATA
TTCC AGGTACAAGT ACTCCCACTT TGATGCTACA GAGGAGTTGC TGAACTTTGT GTCATTAATC T
CTCTTCGTT AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT GGGTCTTCAC CAATTTA
CTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCCTTT AGATTTAAAC AGGTCTCCGT TT
AAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG ACAGTATGCC TGTCAGTCAT ACTACATT
TC CTCAATTCCA TTCATGTGAC TGCTCCATAC CCTTCCCTCT CTCTTCATAC TACTATTATC TCT
TCCCCCC TCCCTCATTT TTAACTGATG ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCATCA
A AAGAGAGTTT CCACAAACTC CTACTGCCTT ATCTAGCCCT GTACCATATA CTTTGCATTT CCTC
TCATTA CCATGGATGT ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTTCCAC TTCAGTTTTG
AATATTATCA GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC ATTCTCTCTC ATTTT
CTTCC ATCAAGTTTT CCTTTTCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT
TTTTCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCT
CACA CCAGTTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGGA G
AAATAGGAA CACTTTTACA CTGTTGGTGG GACTGTAAAC TAGTTCAACC ATTGTGGAAG ACAGTGT
GGC GATTCCTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC AGCCATCCCA TTACTGGGTA TA
TACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGTTTATTG TGGCACTA
CT CACAATAGCA AAGACTTGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATTAAGAA AAT
GTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CTTTGTAGG
G ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACT
GCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA
CCCACTGGGG CCTGTTGTGG GATGAGGGGA GTGGGGAGGG ATAGCATTAG GAGATATACC TAATG
TTAAA TGATGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG
CACGTTGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAAACA
ACTA AAAATAAATC TTCTTTTTCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTGTTTTA T
GTTGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC AGTTGTCACC TCAGTTC
TCC ACTTCTTTTT GCTGATAAAC TACTCTAACT AGTTACATAT GATTTCTGTC CCCAGGTCCC CT
CCCTCAGT TGTTTTGAAC ATAATCATTT ATATCATTTA TCATTTTCAC TCTAATTGCA CAACCAAA
AA CTCCCTTTTT TTTTAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCT
CGGCTCA CTCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTG
G GATTATACAC ATGCACCACC ACACCTGGCT AATTGCTTTG TTTTTGTTTG TGTGTGTGTG TGTT
TTTTTT TTTTTTTGGA CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC
TCACTGCAAC CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGA
CTACA GGCATGCACC ACCATGCCAG GCTAATTTTT TTGTATTTTC AGTAGAGACC AGGTTTCACC
ATGTTGGTCA GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTG
CTGG GATTACAGAC TTGAGCTACT GCGCCGGGCT ATTTTGTGTT TTTAGTAAAG ACGGGGTTTC A
CCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCAAAG
TGC TGGGATTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCCTTTGT TAATATGACT GT
TGGCCTGC ACATTGTCAA ATCCAGTGGC ATTCATCTTA CTCGGCCAAC CTACGGCATT TGACACTG
TC TGTCTTTCCT TCTGTTCCTC TATCTGTTTC CAGTATACTG GCCTGGCTTT CTTTTTACCT CTT
TTATATG CTCTTCCAGT CTCAGGCTCC TTTGGGGATT TGAAGGTATG TTGCATTTTG CTATTCAAT
G AATAATGACA AGTAATGATC ACTTAAGACA TTAAGTGGTC AGTTCCTTTA CTAGGATAAA AATA
ATTTTC TTCCCAACAT GGGGCATATT CCATTTCCAG TCTGACTGTT CTGTGTAATC TTTGTATTCC
TTGGCAGCCC CTTTTATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATTTGCAC TGGTA
TAACC AAATACAGTT GAACTTTTGG CTTGACTCTT AGCTGAACTC ACCAAAAATA ATTTCTGTAA
GAGACTGAGA CGTCTACGAG TAGGTTTTTC AGAATTAGTA AACATAAATC AAGGATACAC AGGTAG
ATTT GAATTTCAGA TAAACAACAA ATACTTTTTT AGTATGTCTA CTGAAATATT TGTATCTTAT C
TGGCAATTC TACCTGGTAC AGAACTAATC CATTCTCTTG AAAGATCTTG ACTCTGTAAT AAGTTCT
TTG GTGATGGAAG GGAGGTATTT CTGTAATTAG AGTCACTGTC TTCCTCCCAG TTTTTTATCC TG
GCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTGCTTTG CAGGAAAA
AA AAATTAAAAA CATCTGAAAA AGCTTTTGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGA
GAACTTT CTGTCTGCAC TTTACATCAG AACAACCTTG GCGTCTAGAA GCTGTGCCCT GTGGGAAGT
G GTGGTGCTTG GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCA
AGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAACGTC
ACGGAGAAAA GGCCAGACTT CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AGTAA
AAAAG CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC
TGCATCATAT GTTTGTTTCT GTTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGGTTTA ACCCCA
TAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC T
CAAGTTTCC ACTGATCAGC TTTTCACAAC TCTTATCCTT TCACTAACTT TGGAGCAAGA TTTGAGA
ATT GGATGGCTAT TTGAGGGCTA TTTCTGCGCT TTAGTTCAAT GTTTTGTTCT TTCTTTATTA GA
GAACTATG GTTTTTTATT ATATTTACAC TTTAAGTTCT AGGGTACATG TGCACAACGT GCAGATTT
GT TACACAGGTA TAAATGTGCC ATGTTGGTTT GCTGCACCCA TCAACTCGTC ATTTACATTA GGT
ATTTCTC CTAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCC
C CTTCCTGTGT CCAAGTGTTC TGTTTATGTG ATAGATTACG TTTATTGATT TGTGTATGTT GAAC
CAGCCT TGCATCACAG TCACTTGCTT ACAAGAAACA AACACTTCAC AGATGGATCA TTATGTGTGA
TAAGTGAAAT CCAAGGATTT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TTCCT
TCAAC CATGAGTGTA TGCAGGTTTT TCTTTTCTTT TTTGAGATGG AGTCTCACTC TTTTACCCAG
GCTGGCGCGC AGTGGTGCGA TCTTGGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA TTCTCC
TGCC TCAGCCTCCC AAGTGGCTGG GATTACAGGC ACCTGCCACT GTCTCCGGCT AATTTTTGTC T
TTTTAGTAG AGATGGGGTT TCACCATCTT GGCCAGCCTT GTCTTGAACT CCTGACCTCA TGAATCA
TCC TTCTCAGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT TT
TTCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTTCCC AATGAAATAT AAAACTAAAG TGCTAAAC
TG TGATAGACTG TTTTACAAGA ATGCCAGTTT TCACAAGTGT CTATAGAACA TGTAATTTAG ATA
GGTAAGA TGAAATTTTG ATAATATTTG ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAATTC
T AAGCCCCTCA ACCAACTGAA TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAA
AAACTA GTTTTGGCCA GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA TTCTCTCCTC
CCTTTGGAAT TCAGGCACAA CTGAATGTCA GCATTGACAC TAAAACACAG ATCTTAAGAC TGACA
AGCCA GACTCTTTGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTTATTTTAT CCCAAAAAAT
ATTTCTTTGA TATATTTTCA AATGGCCCTG CAAAGCTGTC TCTTGTGGGG AAAATTGACA TGCTGT
ACAG AATTTCCTTC TCTTTCCAAG TTTTTACTGA TCCAGGAGAG ATTTAACTAA GAGGCTAGCA T
GTTTTTTTT TTTTTTTTTT TGAGGCGGAG TCTTGCTCTG TTGCCCAGGC TGGAGTGCAG TGGCGTG
ATC TCAGCTCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATT CTCCTGCCTC AGCTTCCCGA GT
AGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA TTTTTGTATT TTTTGTAGAG ACAGGGTT
TC ACCATGTTGG CCAGGCTAGT ATTGAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAA
AGTGCTG GCATTACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTCTGA
A GCTACTATCT AGAGGCTTCA TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTTATCT TATC
CTATTA GTTTCTACTG ATTCCAGGTC TTTAGATAAT AACAACTCTT TCAACCAATT GCCAATCAGA
AAGTCTTTGA ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTTATC CCGCCTTTCT GGACT
GAACC AATGTACACC TTATATGTGT TGATGGATAT CTGCCTGTAA CTTCCATTCC CCTAAAATGT
ATAACATCAA GCTGTAACCC AACCACCTTG GGCACATGTT TTCAGGAACT CATGAGACTG TGTTGC
AGAC CTTGGTCACT CATATTTGGC TCACAGTAAA CTTCTTTAAA TATTGTATAG AGTTTGGCTT T
TTTCATTGA CACAGGAAAA ATAAAGAATT GGAAGGTCTT TCATCAGTCA CTGAGCCAGC TTCATAT
CTG ACTGAGGTCA TACAGTTCAG TGATTTGTAG CTTTGCTACT TAGATTGCTA TCCATTATCT AG
AAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA CTTTCCTCCT AGAACCCAGG ACCTTGGA
AT ATTCTTGGCA CATAGTAGGT GCTCAATACA TATTGAACTC CTAGGTGCAA TTCATTAATT CAT
GAATTAA TGAATTAACA CGCTCTCAAA GTTTAGTGCT TTTTCACAGA CTAGTCTTTC TGCCTCTTA
A GCACTCAGCT CACCACGCTT CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTGCTTA CATG
TGAGTC TGAGATCAAG TGTTATCTCT TCTGAGAAGT CTTCCCTCAC TGGCCCAAAG GAATTTCTCC
TCTATTTTAG CACTGTCCCA GTTGACTTGT CATTATTCTA GTCTTTTTCA TATTAGTTGT TTTTC
ATATA TATGTTATTA AGGAAACTAG TCATTTCCCC TAATAGAACA AAATTGCTGG CCTTTGGGGT
TGGCAATGGA GGGGAGGCTC TTCTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATTTTTCT TACGAG
ATTT ATGTTGCTCA TCTTTAGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC AGAGACCATC T
GTTCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA GTTTTCC
TAG CTCTTTGATC AACTTTCAAA GTTTTACTTC CATTTGAAAA TTTACTAAGT CACCAGGAGA TG
GTTTATAC TGAGAAATAT CCACTCATAC TCTTCCTCTT CAACTTTCTT CCATATACAC CCTATTAC
AG GGATATAGTC TTACTCTATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAA
ACATTCT CACCAGAGGT TCACTTGTGT ATTTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAA
T GTATCATTTT AACTTTAGAT TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT AATA
TTTATT TATCAAGTGA TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT
GTTACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ATTTTTTTGC GACAG
GTTCT CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTGAACT
TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCA
TGTC CAGCTAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT ATGTTGCCCA AGCTGGTCTT G
AACTCCTTG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCC
ACC ATGCCTGGCC ATAATCAATA CACTTTTAAG AATGCTAGAA TGTTATATCA GATGCATACT TC
AGCACTAT CTCAAGCAAA CTGGGGTGTG GGTTATTCTA CATATAAAGT TCAGCAGTGT TGTTCCAC
AG TCCCAAACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGG
CCTCTCC TTGCACTCTT GCCAACCCTG TTTCTTGATT GTCTCTACCA CCATGAGTCA CCAGCAATC
T CCCACAGTCA CTTGTTTAAA AGTTCACAAG TATTGTGTGA ATTGCAGGCA ACCCCTTGAC TCCC
TGATTG CCTGGTCTTC TTCCTTGGGC TCTACCATTT TTTTTCCCCA GCACTCTTTC TGCTGCTCTA
AATTTTAATT CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CTTCC
ATCCA ATTTTGTTTG TCTGTTTGCT TGCTTGCTTG CTTTAATACA TTTCTCTTTT TCTGAGAAGG
CTTGAGTCCA AAACTCTCAG TTACCTGTTG TTCTGTTTCC CGTTAGTTAA TCTCCGAACC TTCATA
AATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC A
CACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTTT TTATAGGAGA TCCAGGA
GAA ATGAAGTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA CAAGAGTAAA CTTTCTTATA AG
TGGTAATT TTTTTTTACA GGAATAATTG AAAATGGAAA TTACCTTCTC TACTCATAGT AAGTACTC
AG TGCGTTCTTG ATGGGATGAG AATGTGTTTG AGCTTTAGTG TAAGGCAGAA TTCTGTTTAG TCT
GCCAGTA TTGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCT
C AATTCTTCCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG GGAG
AGTTCT CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT
CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TTGGG
CTCTG GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT
GTTACAGTGC ACTCTTTCAG CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTTC TTCTTG
GTAC CCAGGTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA AGGATGAATG T
GGGAGTTTT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGA
GTG GGAAGATGAT ATTCTCCTGG AGTTTGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CC
AGCCTCTC GACGTTCAGA TGCTCCTCTT CTCTCCTTCT CTGCCATGCT GTTCTGCCGT TCATCTGC
CT GTCTCTCTCT GGAGCCTGGA ATTTGGGGTT TATATGGTAC ACAATAAGGG GCATGGCAGG CCA
AAAGGGA ACTTTTTAGG TGCAAAAAAC AGGAATGCCT CTTCTCACTT AGGGCTATAG ATTTTCAGG
C TTGAAGGTGG GGCCTTTACC AGCGAACCTG TATTTCCCTG TCTCCTGTGC ATATCAATGT AATC
AAATAC TGGGCTGATC CAGGATGTTT CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAGGTT
TTTATATTTG CTTTTGTCAT TTCTTTTTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGA
TGATA GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA ATGATTTCAA CTGTAACTAA
GGTTATTTCT CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTGAAGTAT TTCAGA
AACA CAAAGAGGGA GGTTATATAA ATAATATTTT TTTCCTACTT TGGGAAAATG AAAGCTAGTC A
CAAAGTTAA ACGAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG TATTTCCTGT TAAAGAA
AAT AAAATGCAGA ATATTCAAAA CGTCTGACCA CCCTTCTAAG AAAATGCATC TCTGAGGTAT TT
TTCCTTAG AAGTTATTGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCAGAG
TT TAATCTGTGG AAAGCTTAGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCTCTGAAG ATT
TTTAAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATT
T GCTGTGCCAC TGAGCTGACT GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA CACG
CATTCT CCCTTTAAAA AAAATGCCCA CACACTGAAT ACTTTTTTCA TGCAATTTAA AATAAGCGCA
CCATCTAGTT TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GAATT
TTGAG CTCTAGGACA TTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATGAC
AGAATAGAAA TTTCTTTTCC TATTTATCTC TTTGAATAAA ATTTTCAGGA TCTTACAGTG GACAAG
TTTG TTATCTACAC ATTGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA GATCTGAGAG G
TGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTTTAC TGGTGGA
GAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC TA
ACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAG
AG AACATCTAAG GCTCTTGAAT GGGGCGATAG GGACAGATTT CAGCAGCCAT CTGACTTCAG TGC
TCATTTT GATGCTTTCC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCAC
A CAGGAATACT TGCTTCTGTA GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACAG ATTC
TTTCCT TGGCCAAAAT TTAGTTAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG ACTTTTTGGT
AAAATCCAGT TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AGTCA
CTATC TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTTAGATT
AGAATCCTCC TTACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCTTGAC CCACCT
TGCT CCTCGGCTAT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT CTCCCCACTA C
TGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC TTACCAT
GCT TTAACAAGTA ACATTGAACC ATTTTTTTCT TTAACAATCT GCTGCACAAT GAGATTACTA AA
ACTTTATT CCATTTTGCC ATGCTGGATG TCCTCAATGG AATGGCTCTT GTGAGCACCA AATCATTG
TG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT GTAACGTGAT GTATGTTACA TGTGATGTAT GTT
ACATAGT TTTTTTTCAT GTTGATCACT TTTTGCCCAT TTTCCTATAT CTTATCAGTT GGAAGACTG
T GGAAGTTTGT AGTACTAAGC CACAAGATGA CTAAGAAGAG TTGAAAGGGC AAGTGGGGCT AAAA
ACAGAT TTTGTTTGAC TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA
GCATCTTTAT CTTTGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTTG GGGTT
TCATG AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTTGAAC
AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC TGAGAC
AGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTCTACT T
GAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG AATAGTAAAT ATGTTTT
CTC TTCCTCCTAA TTTTTTAACA CTTTCTTCTC TCTAGCTTAA TTTATTGTTA AGAATACAAT CT
ATAATACA TATGACATAC AAAATATGTC TTAGTTGACT GTTTATGTTA TCTGTAAGGC TTCAGGTC
AA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG GAGTCAAAAG GTGTATGTGG ACTTTCAACT GCA
GGGGGGT GGGCACCCCT GCCCCCATGT TGTTCAAGGG TCAACTTTAC TGCCAAAGGC AAGCCTTTA
C ATCCACTTTT TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCT
TTTTTT TTGCAGATCA CAAATTGGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCACTTTCT
TTAGTAATAT TTAAGTTAGA TAATATTTAA GTTATAAAGT TGTTCTTTGT AATCGTTAAT TGTAA
TTTTT ACATAGTTTC TTTCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGATGATG
AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT AGTAGT
CATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC TTGGACTGCA G
TAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GGTTGCGCTA GTTATGATGG CAATTTT
AAA TGTGTACTTT TACCCAAAGA AAATCCTTAT TATCAACAAT CACAATGCCA TCATAACCAT GG
TATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CAGAGTTT
CC TTGCTATTCC TCTTTTTCAA ATGACCATTT AGTAAGCACC TGAAGAAAAT ACTATGGACG GCA
TTGAAAA GTGAAGATAG GTTTAATCTT CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACTTA
T CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACATTTGACA CAGAGAAGTC ATAA
CTCAGT CAGCACAGAG ACATTTCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT
GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTTTAAA GGCAGAACAT AGCAC
ATATG TGACTGGGTT TTAGAAGCAA ATTTACAAGA CGCACTCTTC TTCATCCTAA ATAATCTGCA
ACCAAAGCTT CCAAAAAAGA CAATTTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGATGA
GAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTTTCT TCAGGTTCTG A
ACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT GAGCAGGACT TCCTATC
TGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA TAATAATTTC CACTTATACA TA
GGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT AATCTTCAAG GAACTCTGCT AGGGATAT
AA TATTATAAAT CTTGTTTTGC AGATGGAGAA ATTGAATTTT AACCCAAGTT ATCATAACCC TTA
AATGATT AAATGATACT GTTACATGAG AAAGCTGCGT ATCTGTTTCC TGGATTTGTA GCCATAATT
T GTGTCTCAAG TCCCTTTTGC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TTGGGCTGTT TGAT
ACCCCC ACATTTATCT TTTTTTTTTC TCTTTTTTTG TTGAGAGAGT CTTTCCCTGT TGCCTAGGCT
GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC TCACG
ATTCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAATT
TTGTATTTTT AGTAGACAAG GGGTTTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA CCTCAG
GTGA TCTGCCTGCC TTGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGCC C
CAAATTTAT CTTTAATGCC CCAAATTATC TAGTTCCCAT GACTGGGCTT CTGCTTTGAT CCTTTCT
GCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA TTGTGTCCTG AGCCCCTAGT TAGAGGCTAT GT
CTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC ATTAAAAGTC TAATTCTCTT GGAGAATT
GA GAGATACCTA TTTGTCTCAA AATCATTGAA ACCAATTAAT GTATTATGAG CCTCTATCCA GTG
ATTTGTA CCTCAATTCC CCAATCCAGC TGTCAAGGCC AATTTGTTCT ACCTTACCTA GTAGGTAAG
T CTGGAATTGT AGCTGTGGCA TTTTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCTT TTTG
GCACCA GGGACCAGTT TTGTGGAAGA CAATTTTTCC ATGAAGGGCT GGGCAGGGGA GTGGTTTCAG
GATGAAACTG TTCCACCTCA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT AGATC
CCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG
ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTTGCCTAC CGCTCACCTC CTGCCGTGCA GCTCAG
TTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGTTGCTAGG T
ATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG TATCTGATGA GATATAA
ATT ATTTGATTAT AAATTACTTT CTTCATATTA GAGTTGTGAA TGAGTATCAC ATATAATTAT AC
ATAAACTA GGAATATGCT TTTTAATAAT GTATATAAGT AAGTTTCCTT AACTATGACT TTCATCTT
AG CGTAGTAAGA GGGTGCTAAG AAATATTTGT GATGAAAATA GGCATTGGTA GAGTTGAGAC CAC
TGGGTGA TGAAAGAGTG TAAAGATTTT AAAGCCTTCA GATGCTGGTT CAAGGTGAGA AATGTGATT
G GGAGCAAATC AATTAACTTC TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAAC ATAT
GTAAAG CTCTTCTGCC CTGTATACAG TAAATGCTAG TTAGCTATTA TGATCACTAC TAAAATGGGG
ATGACATAAA CCTCATAAGG TTTTAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCA
CATTC AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA GAGAGAAAAA AATGCTGTCA
GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA TTTTTG
CATT TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTATTT AACAACTGGT AAGTCTATAC T
CCCCCAAAT CTGGAATTCT CCTTTCTTAT TCTTTTTCCT CCTACCAAGA CCGCAGGATC TTTTACT
TGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT TACTTTTATA CTCTGTCACA GA
TTCCCTTT GTTTCCTCAT CTCCATGTGA ATTTAGTTAA ATTCTCAGCA TTCTGATCCT TACTATAC
AA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTATTTACA TAAGGCCCCA ACC
TAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGAC
T TGAGAGAAGA AATGGCAGGA TTTCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAAA AGGT
CAAATA GAATGAAGAT GGAGAATACC GGATTTTCTT ACAAAATGAT TTCCCAGGAG ATCTCATCAA
ATGCACGAGG ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTACA
ATTTG GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGAAA
TCAAACACTC AAATTTTTGG TCCTTCTGTT TATTTCATTT TGGATACTCA GTGAATGTTA ATTAAC
CAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA TTTTGAGTAT T
CTGGTCTTA AAAACATCTC TTTCTTCTAC AAACTTCTGA AAGAGATGAA CACCTCCACC TACACCA
AAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCATTTTTAC TTAACAGTCT AAGGAAAGTC TG
GTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT CTGAGGTGAG AATGAGATCA TATTTTAC
AA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC AAAACTCAGA CCACTCACCA GAAAAAAATC GGC
ATTTATA TAGTTGTGTT ACTTTTGGTT TCCTGCATCT TTTCACATCT GGCTCATTTA CATCATTTT
C TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTG
TTATAA TCTTGAAAGT GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCTGAT
CCACAACCAA GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GCCAG
GAGGT CAAAGGTACA TTCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT
GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG TTTTCA
CTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT CTAACATCTT C
TTTAAATCT TTAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT GTTTTCCATG TGGCTCC
AAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCATTT TC
CATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TTTCTGTC
CC TCTCTTCTCC TTTTTGACTT TCTGAGACTG ACAGCTCTTT TGAGGAATCC AGGGTCAAAG CTC
CATCTCT AATGGGTGTT AATTCATTTT CCAGATGGTC TTCTATAGTG AAATTAAACT GAAAGGTCA
T CCTCTTATTA AATGCACACA ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTTG ATGA
TACACA CAAATCTGCC TCAATTATTC AATTAGTTTT GTTGGGCCCA ATTTCTCTTT AGCAGCTTAT
ACATGGTAAC AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TTGGTCCTCT TTCCA
AGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT
TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTTTTT
CTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA CCTTAAGGGT T
CCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTAC
CAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTCTTTC AG
CTGTCTTG ATTTGTGTCC AACCATATTC ACCCCCTAAG CTTCCAGAAT AACTTCACTT CTGTCTTT
TA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA GTCAGCGTCC CTTTAAAAAC ATGCATAGGT ATG
GCCTGGT GTGTGTAAAT TCATCCAAGA CTTCACTCCA AACATTTAGT CGAGAACAGC AGCCCTAAG
T GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCA
AACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTTATT GAGAATCTTC
TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATTTT CACAGTTCTG GCAAGTGGGA TCTTT
GTTCC CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC
GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC GGAACA
AATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA TGTTTACAGT G
ATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT CTGAAAAAGC TCACCTC
ACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CC
CGACTTTC TTTCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGGT
TT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTTCCGGT CTGGGCTTTG GCG
GGTCTGG TTTGAAGCTC TCCTGTTTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGC
G GTTCCCCTGG AAGAATTAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCC
TGCCCC GACTCCTCAT ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC
GAACCTTTCT CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCGGCCT GAACC
CCCTC TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG
TAGATTTAAG TAAGGCTTTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT TAGCAG
TGGA TGTGGCGTTT TCTTCCATTC CTTCTTTCAG TTTTTCTGTA CTCGTTGCTT GCAATTAAGT G
TAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCT
GGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCTTTT GTCTCCCGTA AAAAGGGTGG TG
AATATGAA TAAGGGCTTT CTTAGCGTTA TAAGAATTAA AGGGCATAGT TCTGTGGTGT GAAATCTT
TA AAAGATGTTC AGTAAATAAA AATGATTTTC CTCCTTCCCC TCTCAGACCT CTTTTTCTTC TTT
CTTTCTT TTTTTTTGAC AAGTTCTCAC TCCTCTCACC CAGGCTGGAG TCTTTCTGAA AGAGTTCTT
C CGCTTGTTGT TGGCTTTCAA CTGTTGGATT TGAGGCGCTT AGCGCCTTCT TCGTCCGGGT GCAG
CACATT CTTGATTGGT CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CTTTCATGGT
AAACCATATG TATATGTATC TTTTTCACAA CATTTGAGCC CAGCTTTATA CAATTACACT CAAAA
GAAAA AAAGTAACCT TCACTTGAGA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAAGCCCT
ATGTAATCAC ATAGAAGTCA TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC CCCCTT
TTTT AGTTTTTGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTT TCAACTTGAA AACAAATAGC C
ACCCTCAAA ACATTCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGGCTT
TGG GAGAACAGAG ACACGGAACG TGATTCCTCT TCTTCCCCAC AAGCTTATAG AGAGACTTCA TT
AAGTTGAA AGTCAACATT CCCACCTAGC TTTGCACTTC AAACGACATA TTCAAAAAAG CCCAAACT
TC CTCTAGTTTT CTTCATCTGA GTAAATGGTT TCACAAACTG AAACCTTGAA TCCTCTCTGT CTC
ACACACC CGATCAGTAA GTTCTATTGT TTCTGATTCC AAACTATGTC TTGAATCAAT CCGTTTATC
T CCATCCTCAT TGCTACCACT CTGATTCCAA ACCCTTATCA CCTCTCACTT GGAGTATTAA TAGT
TTCCTT GTTTCTACTC ATAATTCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTCGTC
ATTTCCCTTT TTAAACCACT TTACCTTCAA GGTTCCAGGT GATCTAAGCC TTGCCCTTCT CTCAT
ACCTA GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATCTTTTTG
CTCAGCCTGA TTTGTTCTCT CAGCCTTTTG CATATTTCAT GTTTATGTCT TGGCCCAAAT GTCACT
TCCT TAGAGGGGCT TTTTCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA GTCTTACACT T
GTATCACAT TGGCCTGTTC AGTTTTCTAA AAAGCACATT ACCATTAAAA GAAATGCTCT TGTTTGC
TTT GTATATTTTC CACTTCTACA CATTATGTTG CAAAGTTCAT AAAGGCAGGA TGTTGATTTT CT
TCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC ACATAGTAAG CATTCATTAA AGGGCTAA
AA ATATTTCATG TTTTAAAAAT ACTTGGGAGT CTAATTAGAC AATACTTTTT TTCAGCTTAA TGG
TAGTATT TTAGCTTCAC TATTTTAACA AATGAAAAAT TTGCAATAAA TCTACAATGC CATTACCCC
C CAAAATCTTT TTCATGTTTT GCATTTTACG TATTATTTTC CAGGCCTTAC CTGCATGTCT GCAT
AATCAT AACTGACTAA TTTTGGAACA GCTGGTAATT ATTTGAGCTT TACTGAAATT TTTTCATGAG
GCCAATTCTA CCCTACTGAA CTCAAATTTG AGTTAATGAT GACCTCATTT TGATTGCTGC TGTAA
AAAAT AAGATTTCGG AAGAGGAATG AATTCTTGTA TTACTGTGGT AGGACTATGG GTTTTTTTTT
GTTTGTTTGT TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT GCGATC
TCAG CTCACAGCAG CCAGGTTCAA GTGATTCTCC TTCCTCAGCC TCCCGAGTAG CTGAGATTAC A
GGCACGTGC CACCATGCCC GGCTAATTTT TTGTATCTTT AGTAGAGATG GTTTCACCAT GTTGGCC
AGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TGCTGGGACT AC
AGGCGTGA GCCACCGTGC CCGGCCGGGT TATTCATTTT TCTTATTAAC ATTCTTTGAT GATTCTTA
TG GTGTTGTTAC AGTAAAACAT TTCTAACAAT TATTCTAACA ATTATTCTTG ATGGTGTATA TGA
AGAATTT ATTGTCGTGT ATTTGTAAGC TGCTATGTGC AGAAGAATTT CAGTCAAATA AAGTTGGTA
A GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAATT AAGT
ACAATA GAAATGTTGA GGAAAGAAAA ATTTCTTGTA ATAGAAATCG GAAGTACAAA CTGGGCATGG
TGGTGTGCAT CTCTAATCCC AGCTCCTTGA GAGGCTGGTA TGGGAGGATC ACTTTAGCCC AGGAG
CTTGA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGTCT
CTCTTTTTTT TTTTTTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT TGGCTC
ACTG CAACCTCTGC CTCCCAGTTT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG CAGCTGGGAT T
ACAGGTGTG CGCCACCATG CCCAGCTAAT TATTTTGTAT TTTAAGTAGA GACGGGTTCT CACCATA
CTG GCCAGGCTGG TCTTCAACTC CTGACCTCTT GTTCGCCCAT CTAGGTCTCC CAAAGTGCTG GG
ATTACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TAAATAAA
TA AATCATAAAC CTGTGGATTA TTGTAGCATT GTTTCTCATC TGTCAAAAAT ATTTCATGAC TAT
GCATAGT TTGAAAAGGC AAGTTTGTCC CTGGGCAATT TTCAAAATAT TTCTTTAATG TGTTTTCAC
A ATACTGTTTA CCTAATAAAT CTTAAGTTTT TAAAAGCAAA ATTAAGCCAG TAATTTGAGT CCAA
TTCCAA TCTCTTATGA GTCATTGCTT AAATTTCAAA AGGGTTTTAT TTTTTTTTTA GGTTTGTTCT
GAGTAATGAA TACCCTATTA CTATGATACT AGTATCTTCC TTAATTATCC TACTCATTGT CTCAA
CATTC TGACAGTTGG ATTGAGCATA TTCGTAAGTA AAATTGTTTT AACTGTATGA TGTACTTTGA
TGTTAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGTT CTTACAGTTT TGTATTCCCT TGAAAT
GTAA CTGTTCTCTA TGTTACAGCC TTTATAACCT TCAGTTACTT GAAATGAACA AATTCATTCA A
ATTCCAGCA CTTAAAAGTT TTAAATTACA TTTTGGATAA ATACCAAAGT GTTTTGTTGA TGATGTA
TGT ATAAACAAAT TGTAAATATT AAACGTTAGT TGTTACGATT AGACCTATAT AAAACATGAT AT
GCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGTTTA GTGTCATTTA GAAAATGCTT TCTAAATT
GC CAAAAGCTGA TTGTCTAGGT GATAACAAAT TTACCATTTG GAGGAAGTTG ACTTTCTCAT TTT
CATGTCT TCATCAGTCT TACTTGATGA GATTCATTCT TCTAGTCAGA AGAGAGTTTA GACTGCTCA
G TTTACTCATA TTTTGAGTTA GCTTTTCTAT TTAGAGTTCA CTTGGTTGTG GAATATTCAT TTAT
AATTTG AATCTACGTT GTGTAATGGG ACCTAATTTT TTTTTCCTTT GTTTTTGTTG GAGTCTCGTT
TTGTCACCCA GGTTGGAGTG CAGTGGCGTG ATCTTTGCTC ACTGCAACCT CCACCTTCCA GGTTC
AGGTG ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGCCTGGC
TAATTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCATGT TGGCCAGGCT GGTCTCAAAA CTCCTG
AGCT CAAGTGATCC TCCTGCCTTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGCTGAG C
CTGGCCCCA GAGTTTGTTT TGTTTTGTTT TCAAGACAAG ATCTCACTCT ATTGCCCAGG CTGGAGA
GCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTATT CTCCTGCCTC CA
TCTTCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT GCTTGGCCTG TGTTTTTGTT TGTTTGTT
TT GGGGGACAGG GTCTTGCTTT GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCA
CTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGC
A GGTGCGTGCT ACCATGCGTG GCTAATTTTC TATTTATATA TTTATTTTTT GGTAGACATG AGGT
CTTGTC ATGTTTCCCA GGTGGTCTTT AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCACCCA
AAGTGTTGGG ATTACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTTTTT AAGTAAATTA TTTTT
TTATC TTGAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAACAGAA
AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATTTTG ATGAGAACAG TCTCATCTCA TTTCCG
TATA TTCCTGCCAG CCTATCCATC ATTCTTCGTA CATGTTTATC TACATTAAAA TTGGTGTTAT A
TTTTGGAAA CTTTTTGTTT AACTACATTG TGAACATTTT TCATGTTTTA AAATGTCATT TTAATGA
TGG CAGATCCTAT TCAATAGATG TACACACACC TATTTAACTG GTCCACAATT GTTGGATATG TA
GGTCGTTT CCTTTCTCTC TTTTTTTTTT TTTTTGGCTA CTACTTAATA GTTTCTCTGT ATAGAATG
TG GTATTTTGAA AGTGTATCAA GCTTTAGATT GGTAGTATTC TTGCATTTAA TAAAGGGCAG TGG
CCTTTGT TGACTGACAT GACAATATTT TTATAAAATT TGTTATTTGC TTTACAGAAA TTTTGAAAA
T TATTGTAGAA ATGTTTTTAC CTCATATGAA CCACCTGACA TTGGAACAGA CTTTCTTTTC ACAA
GTGTTA CCAAAGGTAT AATACTATTA CCTGAAAATA CATGTTATAA GGAATCTAGC CTCAGTCTTA
GATGATTTAT TATTAATTAT GGCTCTCTTT TTCTAATATA TCAAATATAT TCAAAATAAA AATAA
GGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATTAGGCAG TTAAAAACTG
TTACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG GCAGAT
CATC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACTAAAA G
TACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT GAGACAG
GAG AATTGCTTGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA GATCGTGCCA TTGCACTCCA GC
CTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACTTAT ATTTTCAG
AT TGTGTGGTTC CTTTACTAAC TGAATTTAAA TTATTTGTAG TCAATTTTAA ATGCTCTTGT ATT
TTAAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAAAAA
A AAGAAAAGCT GGAATATTGG CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGAA TACA
TTATTA CATTTTAGAT ATATATGGTA TATGTTTTCT CTGAAAAGCA CAAGCATACC TTTTTTGTTT
TAAATGGAGG GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG TAATTAATCT CTTAT
TGAAA TGGGTTTCTA ACTTTAGCTT TGAATCGTAA TCTTTCAAAT TTCTTGTACT CATAGTCACT
TGATGATTCT CTATCTGAAA TATTTCTTAG AATTTGTTCT TGACCACCAG AAAAAGATTC AACTGT
TACA TAGATGAAAA TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT TCTTTAGCTA C
ATTGTATTG TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCATTTAA ATTGTTAGAA AGATCCA
AGT ATTAAGATCT AGGGTGGCTA ACTTTTCACA GACAAAAAGC TTGTTTGTAA GGTCATTTAC TA
TACCCTTA ATTCAGGAAG GTTAGCTTGA ATTGGGTCAA AAGGAAACTG GTTAGAAAAT AAGTGAGT
AG TGAATAGGCG ATTCAGTGCA AATTCCTTCC AGAAAATACC CTTGTAAATG ACTGTATGAA TGT
GGATTCT TCAAGACAGT CAAATTTATT GTGCGAAAGT AATACTTTTA TTTTTTGCAT CTCTAAAAC
A TGAACTTTGA GTGATTTTTT AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAAA TGGA
AAATAA ATTTCTGTTT GGGGCTTTTG GGGGGATTAT GTTGTAAAAA TACCTTTTCT CTGTATTTTG
TGCTTAATTA GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATGTTAC TAGTGCAAAA TCAAA
TTATC GTATTGTGTT TTCTCTGTAA AGTTTTGTCT TGTCTTTTCT AGTGATTTCT CTTATTCCTG
TTTATTACTT GATTTGTTTT TACAGACTGT GAAATTATTC GATGACATGA TGTATGAATT AACCAG
TCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA ATCCAGACCA CTCTAAGGAA TATTTTACAA G
TAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAATTTTT ATACTGA
TAC TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA ATTAAATTTA TAGAATTAAA GA
CGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AGCTAGCT
GA CCCTACCTGT ATTTTCAAGG ATATGTGTGG AACACCTGCC ATGTGTTTTG AAGTTTGTGT TAG
TATTCTA AATGGCTAGA CAGTTGTTCC AGTATTTGTA GTTCTGATAG ACTAAAGTTC TGTGAAAAG
A GGAAGAGACT GTGTTTTGTT CATTGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATACC TTTT
CAGTGC ACAAAAAATA TATTCTAAGT GAAATTTCCT TCCTTATTCA CAGACAATGG TGCAGCTCTT
AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATTTTGGA AAATA
TTCAG AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCATTG TAAGGTGAGT
AAAGGTCTAA TTATACTTTG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA ATGTTT
GTAT AAGATTTTAC ATTTTAGTCT ATATTATTGA AATAAACTTT TCCATAGAAT AAAGAACATG T
AAGTAAATA ATTGTTGCAA AAAAAGTGGT TTTAAGGAAG TCATTAAAAG TGGCTTTTTG GGGTTTT
TTA GTTTTATCTT ATTTCCCCTC TATAAAGAAA GAAGTTTTAA GAATTTGTGT TGAGACAGAC AC
AGGGATCC TGAAATAGTT ATGTCATGTT GCATTGACCA ATATTCAATT ACCATTATGA TTAGATGT
CA GAACTTCCTT TTATAAAGGA AAGTTAATCC TTATTTAGTC CATCTCTACA TGCCAGAGGT AGC
CTTGAGG CACAAAAGCT TGCCTAGAAT TTATGGGTCA CAGACAGTTT TAATATTGCT ATTTGTTGG
G CGAATGAAAA TCACTAGTTA ATTAATACCT CTCTTTGCTG ATAGGATGCT AAAAATGTCA CGCA
CCTGGC CTAATGTTAC CCTTTTTTAG TTCTGTATTT GCAAGATCAT GGAAGTCAGA AATAATATTT
TATACATGCT TGCATCTCTT GAAGCACACT ATATTTAATG GATGTTCACT AAACAATGAA TGAAT
ATGTG ATTCAGTAAA TTTATGATCT CTAATAGTAT GAATTAAAGT AAATTTGGCT CTTGAGCTTT
GATTTGTTTT TTCTCTCATT TTTATTTATC CGTAATCAGA ATAGTGAATC TGTGTATTCT GGGTGT
TTAC ACCTAGTTTC AGACCTTCTC CAGGCTCTTT TCAAGGAGGC CTATTCTCTT CAAAAGCAGT T
AATGGAACT GCTGGACATG GTTTGCATGG ACCCTTTAGT AGATGACAAT GATGATATTT TGAATAT
GGT AATAGGTGAG TGAAGAAAAC TTTCTGCTTA GTATATGGTG ACTATAAATC ATGTATCAAT TA
AAATTGTC TCTAATGATT CATGTTATTT TCTTACTAAT TATGCATTAA AATTGATTTA AATCTTAC
CA AATAAATTTT TAATCTTGAA ATTTGGAATT TGTAAAATTT ATTTTGGGTA CCTTAACCTA GAT
TTGCGTA TTTAGTTACT GTAATTTCTC CACAATGATT AACTTATATA ACTTTATAAT CTCTGAGGT
T GTCCATATTC AGAGACAATA ACTTTCACAT TTTTTTAACC ATAACTGATA TTGAGATGCA GTTT
ATATTT CCTTCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCATATA
CATATTATAA TGAAATAACT CATTTTACAT GTGATGCACT TTATACTAGT TTATTTTTAT TTTAT
TTTAT TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCGGC
TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT GGGATT
ATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TATTTTTAGT AGAGACAGGG TTTCACCGTG T
TGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA GCCTCCCAAA GTGCTGG
GAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGTTTAT TTTTAAAGAA TTGCTGGTCG TA
ACACACTT CATTGATTTT ATCACTCATT AATGGATTAT GAACAAGAGT TTGAAAAACA ATATAAAG
GC AAAGTTTGCA TTCAAAACTT TGGTATAAAG AGAGTAAGTT GGTTTTGTGC AGTGTATCAG GCA
CCTGTTG CTCTGCAACA CACCACCTCA AAATCTATTT ATTCACTATT TATTTATTCA TGATTCTGT
G AGTCTGCAGT TTAGGGTGGG ATGTCCTGAG ACAACTTTCT CTGATCCACC TGGGGCACTA GCTC
ACCCAT GTGACTTCAG TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTTGAGAAAG
CCATGTGCAT CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGGTTTCAGG GTTTC
TAAGA GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG CTAGCACTTT TCAAGTTTCT GCTTGCCTTA
ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCATTGTAG AAAAGT
GTGG ATTCACAAAG GGCAGTCATT GTGGCCATTT TTATAAATAA TCTACCACAG ACTGAGTAAA A
GCCTTGCAT GAATACCATG GATATTAATT TGAATTCTTC CTTTTTAGAT TTTCTTTCCT TAGCAAT
TTG TTTTGTCATT TTGGATTAGA ATTATATCTG TAGAATATTT CAGTTATAAT AGGGTACAAC TT
TTATTCCA CTGAACATCT TTAGTTTTAT TTAGGTCATC TGGTAGGTAT AAACTTCAGA AGTTAATA
TT CAATATTTAT AAAAACCATT AACAAGTGTG ACACTTAAAT AGTTTAAATA ATTCTTTTGA CAC
AACTGTT TCCAAGTTGT GTTACGTATT TTAATTCAAT CAAATGTTGA AATTGTTCAG TAGATAGTT
T TAATTATAGG AGAAACTCAC CCCCATGACA TTTGGATGTC TTAAAAGTTC TGTTATCTTT CTTT
GCAGTT ATTCATTCTT TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC ATTTCATGCC
AATACTTGGA AGTTTATAAT TAAGTAAGTT TGTTTGTTAT TTTTTACTTT TTAGAAAATG TTTTC
CATAT TCCCCAATCT TAATTATTCA TGATTCTTTA GATTGCATTT AAAACATTTT GTGTGAATTT
AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA ATTGGA
CTTC TTTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC TAGTTAGCTA GTACTTCAGA A
ATAATGGGC CATGGGCCAG ACTAGAACTT AACCACTTTT CTTCTGCTAC TGTTGTTTAA CCAGCTA
TCA AGTATCCTAT TTCTAGGATT AGATAAATTG ATAACTATAA TTAAAACTGA ATATAATCTT TT
CATTAGGT ACTTTTAAGT TGTTCACACT TAATTCCATT TGTACAGTAA TTTTAACTTT CTGAAACT
GA AGCATTTTAA AGGGTCACCA GGGATAGTGC CTGTAGCATT CATCAGATTC TTAGGGGTGA GAG
GAGATGT GGTTGAGATG TAAAAATGGT TAAGAATATC TACTTTATAC ACATACATAA AACATTAAA
G GTCAGTGTAT TTTCAGGTCT TAGGTACTTT TCTTGTACTA CCAGGACATT AAGTTGCCAT TCAG
TGGTTA AGAGTGTTGC CTGGGAGCTG TATCACATGT GCTTAAATCC ATTCTTGAAA TCATTTACTC
CTTCTGAGCC CTTGGGCTAT TTGGTTAATT TCTCTGAACG TTAGTTTGCT CATCTGAAAA TGGAA
ATAAT AATAGCAACT TCTTGACAGG GTTATAGTGA GAATTGAGTT CATCACTGTG AAATGCTTAG
AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT GATTAT
CTTC CACTCTTACC CTCTTCCAGT TCATTTTCTG CCCAGCAGAA TGATCTTTTA AAAAGTAAAT C
AGATCATGT TACTCTATTG CTTGAAGTCT ATCCCATTTG ATTAAGAATA ACAACCTAAT CCTCTGT
GGA TGCTGCCTCC TTCACCAGCC TGTCTCATGC TGCTCTCCCT ACTCTTAGTT CCTCAAACAT AC
CAAACTCT CCTGTCCCAG AGTCTTTTCG TGGTTTTTCC ATCTGCCTAG GATGCTTCTC TCTCCTAT
TT TGTGTACCTT GCTAACTCCT GCTTACTGTC TTTCAGTTCT CAGCTTAAGA GTTATATCTT CAT
GATAACA TTCTTTGATA TCCTTACCCT AAGATTAAGT TAGATTGATA TCCTTACCCT AAGAATAAG
T TAGATTAGGT CTCTCTATTG TAGCACCTTA GACTCTGTCA TTTGACAAAT CACAGCCCTA ATTA
ATTATT CTTAAAATTA TTTAACATTC TCTCTCATGC TAGACCACAA GTTTCATGCA GGTAAGGCGG
AGATTGTGTC CATTTGTTTG ACCCCTTTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAA
GAATT CAATTAATAT TTTACACAGA GAAAAAATTA GCAACTTATT TAAACAAATA TAACTGCTTC
AGAGGTAAAC TGGGCACATC TTAGTTATAT TATGTGATAT ATGATGCTTT TTGATTGTTT TTTTAA
ATGT TCTACAAGGT AGATATTGTT AGAGGTCCTA AGTTACTTGA TGTGTTACTT GTGGTGATTG T
ATTCTTTTC TTTTTATTCA TTTAGGCAGA GCCTTAAGCA CCAGTCCATA ATAAAAAGCC AGTTGAA
ACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTTTTC TCCTTCCATT CTTGTTTACA GT
TAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA TTTGGGCTAA TAGCATTTTA AACAGCAA
CT CTTATTTTCT TTGGCAGTTA GTAAATCTCA TTTGAATGTC TGGGTCAGTC TATTTAAGAG GAT
TTTAATT TATTTCATTT GGGTGTTTTT TTTTGATCTG TGGGATTATT TATATCCCAT AATTACTTT
T CACCCAGAGC ATTGTATTAG ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT CCCT
CTTTGC TTGGTAACTG GTTGGTCACA GCATTCTTCT CAGAATCCTT TCATTCTTTT CTGCATGAGA ACAAAAATTC TTTTGTTCAT ATTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT TTTTTC
TTCA CCAACGCATT GCGACCTTTA GGGATACAAG TATGTTTGTG CATGTATATG TATGTATCAG T
CTTTTAAAT TTGATATAGT CATACATTTG TTTTTATTTT GAAAAGTTAG AGTGTTGAAT TGGTATC
CCA TTTATGAAAC ATTATATTCT AAAAATTTGT AGTACGATTA TTGGGAATTA TAACTCATTT TC
CTGTAACA CTGTTATACA TAGTACCTTT TGCTTTCAGA CTAGCCCTCA ATTTTATTTA ACTATAGT
AG TCCTAAATTA TAAGATTAAT AGTACTCAGG ACCTAACAGT TATATGTCAT TTGTTTTTTT TTT
TTTTGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA GTGCAGTGGT ATGACCTTGG CTCACTGCA
G CCTCTGCCTC ACGGGTTCAA GGGATCGTTC TGCCTTAGCC TCCTGAGTAG CTGGGATTAT AGGC
GCCTGC CACCACGCCT GGCTAATTTT TTTAGTAGAG ACGGGGTTTC GCCATGTTGG CCAGGCTGGT
CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCTTGGCCT CCCAAAGTGC TGGGATTACA GGTGT
GAGCC ACCGCGCCCA GCCTATATGT AATAATTTTA ATGGGACCAT GAATTGAATA TTTCTTCCTT
GAATAGCAAT GACATAGCCC CTTCTATTGT ACATCTGCAA GCTGATACAG GGAATTCCTT TGTACC
TGCG CTCTTCCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GTCCTAAAAC T
GGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC TTTAAAA
AGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTTA GGAAGGGGCT AACTTTTTTC TT
CTTGCTTC TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TATCCCTTCT TCCTTTTTCC CTTTCCTT
TT TTGTCCTCAC TTCATTCGTG CATCCTTTCT GATTCCTCTT ACCTTGCTAA AAGGAGAAGT TTG
TTTGGGT ATCCTATATC AATGGCAGGA AGGTTGTTTT CTTCTTTACC TTTATCCTAT AGATTCATA
T TCTCAACACC AACCTCCTCC TTTTTCAGTT TCCTTCTTGC TTCTCTTGAC ACCACAGAGT TTGC
AGCTAG TACTTGGAGA GGAAAATTAA ACAGAGATAC TTGGACCAAG AGTAAGATGA AGAAAGTCTA
AACAACAGTA TAGTCTATAG TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT GTACA
TAAAG TATATCTTCA GTTTATATAA ACTGCTTATA GATGGAAATC AGAAAATTTA AATTCTCTTA
ACTGTCCAAG AAAATTCTCA TTTTTTCAAA TTTGGGACTG ATAAATGTGA CCAGTTCTGC TTACTG
TCCA TTGCCTGAAA TGGAGCTTTG AGGTGGACTG TATAATTTCT TCAATCTTAA CTCCAAATTC T
GATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATTTAT TTACCAATCA AAGTAAAGTA TTGAAGT
TTT CCTGGCAGTT TTCACTTTGT GTTTTAGTCC ATTTAGGCTG CTATAACAAA ATCCCTTAAA CT
GGGTAAGG GATTATAAAT ATTAGAAATT TATCTCTCAC AGTTCTGGAA GCTGGGAAGC CCAATATC
AA GGCACCAGTA GATTTGGTGT CTAACGAGGG TGTGCCGTCT GCTTCAAAAA TGGCCCCTTG TTG
CTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC CTTCAACCTC TTTTATAAGG GCACTTATG
T CATTCATGAG GGCAGAGCCC TCATGACTTA ATCACTTCCC CAAAGGCCCC ACCTCTTAAT AGTA
TCACAT TGGGTGTTAG GTGTCTGGGA GGACACCAAT CTTCAAGCCA TATCATCTCA CTTGGAAAAA
AGTCAAAATA AAACCAGTAG ATTTAATTAA TATTACACTA TTTATAGAAG CATGTGATGT ATCAT
TCCTT GTATTAATTT CCTGGGGTTG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACAATA
GAATTTTATT CTCTCACATT TCTAGAGGCA GAAGTTCACA GTGTGTCAAT AGGGCCATGT TCTCTG
GAAG GCTTTAGGGG AGAATATATT TCATATCTTT CTCTTAGCTT CTCGGTGTCA CTGGCAATCC T
TAGCTTACT TTGGCTTTCT GTGTCTTCAC ATCATCTTTT TATAAGAACA CCAGTGATAG TGATTAA
GGG CATACCTTAC TTTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA CCCTATTTCC AA
ATAAGGCC ACATTCTGAA GTATTGGGAG TTAGAACTTA AAGCTTTTTG GGAGGGACAC AGTTCAAC
CC ATAACAACCC CTAAAATCGA TATTTATTCT CAATTAAGTC TTGAAATTGG TTTCAAAAAG AGA
ATATTCT ATTAGAGTTT TTAATGTATA GTTTTAACAT ATAGTTCTTT AGCCCCCAAT TTTTTTTTT
T TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGG
ACTGCA GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCTTCCCGGG TTCACGCCAT TCCCCTGCCT
CAGCCTCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTTTTTGT ATTTT
TAGTA GAGACGGGGT TTCACCTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCCACC
CGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAATTA
TTTA GTTTTTCTAT AAACAGGGAA ATTTATTTGT GTGGCCCTTA GAACTAATTT AATTTCCACT C
TAATTCCTA CTTATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC ATATACT
ATT GTATCTGTTG CCTACACTTA GATTTTATTG CCTGCTATAT TTAAATTTTA TTAGTATTTT AA
TTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACTTTTGAGA GGCCAAGGCA GAAGGATT
GC TTGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA AAT
AAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG TTCTAGTTAC TTGGGAGACT GGGGTGGGA
G GATGCATTGA GCCCAGGAGA TTGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCTT
GGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG
ATTATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAA
TAGAC AGATTATCTA AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCTATC
TAAATAGATA ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TAGATA
GAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG G
TGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTCCTTGC TTATATTACC CACACCTTCT TTGTTGG
CAT TAAGATGCAA ACTTTGTTTT AAACAGTTGA GTAAATCAAA GATGGGACTG TTAAGTTATT TG
TGTTATTT ACCTGCTTTT TGAAAATGTA AAAATAAAAC TCTAGGTTTA ATTAGTAGTA TGCTATTT
AG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA ATTTCCTCTT GAATGAGAGA GAA
AATTTAA AGTAAGCAAA CAAATAAGTT GTGTGTCACC ACTCATTCAG TCATTTAACA AGTATTTCC
A GAGTACTTAT TCTGTGCCAG GAAATGTTGT AGGTGCCCTC AACAACTTAG AGTCTAGCCT GAGA
CACAAG TAAGTAGGTA ATTATTATAG AATGGTATGA TCTTTGGAGG ACTGGGTATT GGCTGGCTCA
TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATGA TGACG
TCTAT GCTGATTATA AGGTCAGTGT AGAATAAACT TTGTGCTTTT AAATTTGCAT AGCACTGTAT
TAGAGAGTTC ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCA
CTTT GGGAGGCCGA GGTGGGCAGA TTGCTTGAGC TAGGAGTTCG AGACCAGGCT GGCCAACATG G
TGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT AATGCCA
GCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT GAAGTAAGCC GA
GGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAAATGA
TC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG AAAATGGACT ATTTTCAAAT ATT
TTTAATA AGGGTCAAAA TGAGGGATC GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC
AAAAATAAAC CAGAAACCAC CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGG
TCTCC GCAGCACTTC TGTGGCTGCT GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG
CCAGCTTCTG TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTA
GAGA GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC T
GGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC TGGACCA
AAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATTTTTGAA ACCAAACCAG AGCCTGAGTG TT
GCCTAATT TGTTTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT ATCAGTCCAA AGGGCATG
GG TTTTATTATA TATATATATA TTTTTTTTTT AAAAAAAAAC GTATTGCATT TAATTTATTG AGG
CTTTAAA ACTTATCCTC CATGAATATC AGTTATTTTT AAACTGTAAA GCTTTGTGCA GATTCTTTA
C CCCCTGGGAG CCCCAATTCG ATCCCCTGTC ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCC
TCCCTG GAATCTTGTA AAGGTCCTGG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC
CCAAAGTGTG ACTCATTAAA TGGAAGTAAA TGTTGTTTTA GGAATAC ATGAAGGTCT CCGCAGCA
CT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGT
CCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAG
G AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATA
TCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA
CTCCAAAGCC ATAA CCACATATTC CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT
GTACCAAGTC CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCT
GGTC AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC C
ACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCC
AGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG GTCTCCGCAG CA
CTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCC
CC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCTT TAC
AGACTCA CTGCAAATTC TCCATTTGAA AAATAGGGAA ACAGGTTTTG TGGGTGGACA AGAAATGCC
T CAACCGTCAC ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACAT
TCAAGA GGGCCGCTGG GTGCATCCTT ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT
CTGTCTTACT GTGGGCATGG TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGA
AGCTC AGTATGTTAA TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT
CCCAGGGGAT CTCTTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTC
CATA ACTCATTTTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT G
CATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA ACAAAAG
TTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA TTTTATACTC AG
GATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT ACTGTGATAA AGCAGAAG
AA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA AAAATGACAC CCATCACTTT GTC
TCCTTCT TTATTGATCA AAACTAATTA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGT
C TACCTTGTGT CTCAAAACAG AGGATGGAGA ATATTTGGTG AAAATTACCA TGACCATCAC ATGG
CCACGT AGGTCTTTAT AATGACAGAG CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC
TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAG
ACACA TAAGACTTCA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA
CTTCCTTTAC AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTT
CATT TTTTTTCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG A
AGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTG
TGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC AA
GAACTGTG GGAGTCATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT TCATTAATTT TCACAAGT
GA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA TTGCTGTAGT CATATCAATT TCTTCAAGTC AAG
AGCAAAG ATGGTTTTAC TGGGCCTTTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC TTCCTCCTC
T CCGTAGCAAC CCTTTGTCCA GGGGCAGATG GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATT
TTCAAA AACAATCCTT CCAATTGCAT CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG
ATATCTGTGC CGACCCCAAG AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCT
CCAAC TCCAAAGCCA TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT
TTGTTTTCCC TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTA
TTAT ATATATATAT ATATATTTTT TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT T
AAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT TTACCCC
CTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCTTCCTC CC
TGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTTGT GAACCCAA
AG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTAGGAATAC ATAAAGTATG TGCATATTTT ATT
ATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC ACTGAGCTGA GGGGG GCCAGGTCGC TGT
TGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CGCCATGGGA GGCCGGAGC
C GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG ACCGCTATGG GCGT
GGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG AAGGGCCAAA CGTGTGTGGT
GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGAG ACAGAAACAA ACCTT
TCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA GGTTTTGAAG AGGGTGCAGC CCAGATGAGC
TTGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGT
GTCA TCCCTCCCAA TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG A
AGGAACTCA AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGC
TCC TGCTTTTGGG GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATTCTC TC
TGCCCAAG TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG CTTGAGGAAA CTTCGGTT
GC AGATTGAAGC ATTTCAGGTT GTGCATTTTG TGTGATGCAT GTAGTAGCCT TTCCTGATGA CAG
AACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT AAACCACACA CACAAGGTG
C TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCCAG TTACCTTTGC TGTC
ACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT AAACAATGTC CTCTTTGAGA AAATGTAAAA
TAAAGGCTCT GTGCTTGACA GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTC
GCGCC GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG
AGACGGGCGC ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGA
TGGA AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG G
AGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA CTGACTA
TAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA CATGCCACTC TC
GTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT CCCTTAGCTC CCTGTTCT
TG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA CATGAGTCCA TATGGAGCTT TTC
CTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT GACTGAATGT GTTCTGTCAC TCAGCTTTG
C TTCCGACACC TCTGTTTCCT CTTCCCCTTT CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCC
ATAAAC CTCAAGTTAT TCATTTTATT TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT
GGATATAGGT TTCCAATTAA GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAG
AATAG GAATTGGTGT TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT
TTTATCTATT ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTG
TTGA GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA A
ACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA ACCCTCT
GCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT CCCTGGGCCA GC
AGGGACCT CTGAAGCCTT CTTTGTGGCC TTTTTTTTTT TTCATCCTGT GGTTTTTCTA ATGGACTT
TC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT TCCTAAATCT TAAGAACTTT AAT
TGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA CACCCAGTGA AAGCCCAGCC ATCATGACA
A ATCCTTGAAT GTTCTCTTAA GAAAATGATG CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTT
GATGCT TGGCTCCCTC TGCTGATCTC AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT
TTGCTGTCCT GTGTAGTGAT TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATG
AGTCT CAAGTTTTAT TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC GCCGCCGCCA TGGGAGTG
CA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC AAGCGCGGCC AGACCTGCGT GGT
GCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT GATTCCTCCC GGGACAGAAA CAAGCCCTT
T AAGTTTATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTG
TGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA
TCATCCCACC ACATGCCACT CTCGTCTTCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGG
CCTCC TCCCTTAGCT CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC
ACATGARTCC ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTG
AATG TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA T
GTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA AAGCTTCTAC CCTAGTCTGG TG
CTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC TGTGGCTCCT GTTATAACTA TTATAGCA
CC AGGTCTATGA CCAGGAGAAT TAGACTGGCA TTAAATCAGA ATAAGAGATT TTGCACCTGC AAT
AGACCTT ATGACACCTA ACCAACCCCA TTATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATC
C AACTCACACA AGCTGTTTTC CTCCCAGATC CATGCTTTTT TGCGTTTATT ATTTTTTAGA GATG
GGGGCT TCACTATGTT GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC
CTCCTGAATA GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTATTTA AAATA
TACAT GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA
CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTTTAAT AATAGTAACC AGGCAA
CATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTTCTC CCAATCTCCA TTCCCAAACT T
AGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC ACACCTTCTT CTACAGA
AGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTCTC TGGTCCTTGG TAGAGGGCTA CT
TTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGCTCCATCC CCTCTATAGG AAATGTGT
TG ACAATATTCA GAAGAGTAAG AGGATCAAGA CTTCTTTGTG CTCAAATACC ACTGTTCTCT TCT
CTACCCT GCCCTAACCA GGAGCTTGTC ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAA
A CTTCCCTCTT CAGAAAAGAT GGCTCATTTT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCT
GCCAAT TCACCCTGGA GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT
ATTATTATTA ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTT
CCTCC TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTCTAAG ACTACATGTT TGTCATCTTA
TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC AATAAT
ATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG AAAAATACAA A
ACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC ACGTAGCCAC GCCTACT
TAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG CTGCCAGCCA GAGAGGGAGT CA
TTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CATCTCTGGC TATTAAAGTA TTTTCTGT
TG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTC
TTTTCTT GTCCCTCCCT GGTTTGGTAT GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCT
C TCATTTTGCT GATAAGGACT GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGG
CATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA
AATTGAAAAT TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGG
TGTTT TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG
CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG AGACAG
GTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG GACTAAGTCA T
TCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT ATCTGGATTA GAGGCTG
GCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG ATGGCCAAAG TTCCAGACAT GT
TTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA TTTATCTCTT GTGATTTAAT GAGGGTTT
CA AGGCTCACCA GAATCCAGCT AGGCATAACA GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTG
TAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCA
G CATGTTAAAC TGAGATTACA TTGGCAGGGA GACCGCCATT TTAGAAAAAT TATTTTTGAG GTCT
GCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT
ATAAGAATGG GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGC
TCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG
GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT CTGTAG
TAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT ATAAATTATG A
AATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT TGGTTAAAAT AAAAAGG
AAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACATT CTTCCCTGAA CTTCAATTAA AG
CTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA AAGCACAGGT AAAGCTCAAA GCCTGTCT
TG ATGACTACTA ATTCCAGATT AGTAAGATAT GAATTACTCT ACCTATGTGT ATGTGTAGAA GTC
CTTAAAT TTCAAAGATG ACAGTAATGG CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATT
A AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATTTT GACA
GTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT
AATTCTCATG GGACTGCTAT TCTTACACAG TGGTTTCTTC ATCCAAAGAG AACAGCAATG ACTTG
AATCT TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGAGACC TGTCTTTCAT TATAAGTGAG
ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA ACTATC
CCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT ATGCCATCCT G
AGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG TGTTGTGGTT GTCTTCT
CTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA GCTGAGAGAG AGGAAGCAAG CC
AGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGTTATTGTG TTTGGAGACC ACAAATAG
AC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATT
TCTAAAA TATTTTGAGC ATTGTTAAGC AGATTTTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCT
A CCACTCACTA CAATCATTGT TAACCTATTT AGTTACAACA TCTCATTTTT GAGCATGCAA ATAA
ATGAAA AAGTCTTCCT AAAAAAATCA TCTTTTTATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG
GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCAC
TACCT CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG
CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA AGGCTG
CATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT TACCTTCAAG G
AGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG GTTGAGTTTA AGCCAAT
CCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAGCA CA
ATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC AGTAGAATTT AGGGGAAAAT TAAACGTG
GA GTCAGAATAA CAAGAAGACA ACCAAGCATT AGTCTGGTAA CTATACAGAG GAAAATTAAT TTT
TATCCTT CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTAT
T TCTTAGCCAT ATTGTAAAGG TCGTGTGACT TTTAGCCTTT CAGGAGAAAG CAGTAATAAG ACCA
CTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CCTTGGTCAT GTTACATAAT CTTTTCGTGA
TTCAGTTTCC TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGA
TTAAG AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG
AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA AATGTT
AGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTTTTTTG AGATGGAGTC TGGCTCTGTC A
CCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC TCCTGGGTTC ATGCCAT
TCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC CGCCACTGTT CCCGGCTAAT TT
TTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT CCATCTCCTC GTGATCCACC CACCTTGG
CC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTATTAT TATTATTATT ACT
ACTACTA CTACCTATAT GAATACTACC AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAAC
C TCACAAGAAT CCTACCTTCT CATTTTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACT
GCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA
ATCATGGTTT CTCCTCCATC CCTTTACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCC
TGTTT TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTTTTAAAA TGTAACAAAA
TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG TATGTT
TCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT CAAGACCACA C
TATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GTATTGAGGA CATTTTAGAG TGCCCGT
TTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA TAAATATTCA TTTCTCTCAC CC
TTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC CCAGAGCCAT GAGGATTTGT GACGCTAT
TG ATATGTGCCA CTTTGCACTC TCTGTGACAT ATATAATTAT TTTTAATGCA TTCATTTTTT TCT
CAGAGTG CATTCGTTTG AAAACATAGA CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACAC
C CAAACAATGA AAAATGAAAA AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAG
GAATTG AAGTTTAAAA AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG
ACTGGGTGAT TTCACTTCTC TTTGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAG
AACTA TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG
CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCTTTT AGCTTCCTGA GCAATG
TGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC TCAATCAAAG T
ATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC TGGATGAAGC AGGTACA
TTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTTCA TTTACTTATT TATTTATTTC AA
TCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGGTTGCACA ATTCTTCCAG AATAGCTT
GA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCC
ACAAGAG AGAAGTTTCC TATCTTTGAG AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCT
C TTTGGTTCTT TCAGACATTC TTACCCTCAA TTTTAAAACT GAGGAAACTG TCAGACATAT TAAA
TGATTT ACTCAGATTT ACCCAGAAGC CAATGAAGAA CAATCACTCT CCTTTAAAAA GTCTGTTGAT
CAAACTCACA AGTAACACCA AACCAGGAAG ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCA
AAACC TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGTTTAG TGTCCAAAAA CTTTTATCAC
ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA TTTTCAAAGG TCCAGA
GAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTGGAT GCACTTCAGC TAACATGCTT T
CAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TACTTAATAT TATTTCTGCA ATTTTCC
CAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCACT AGACAATTCA ATCAGGTTGC TA
CGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC AAATATCTTT GTATATATTA TTGTTTTT
TC TCCTATCTTG TAATTTCTTT GAGCACATCC CAAAGAGGAA TGCCTAGATC AATGGGCACA AAT
AATTTGA CAGCTCTTAT TAAACATTAT TCTGTAAGTA AAAACTGAAC TACTTTTCAG TATCACTAG
C AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAA
CAAATT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG
ATTCATTCAA CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTTACCTGC CTAGTGAGTG TGGAA
GACAT TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG
GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA CACAAT
CTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTACTTT CTTTTTGGTT CTTCTCTTCA C
CAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA AATTACCGTG ATTCTAA
GAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA CCAACCAGTG CTGCTGAAGG TC
AGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT CATATGTTTG TAAATAAGCC CAATAGGC
AG ACACCTCTAA CAAGGTGACA CTGTCCTCTT TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCC
ACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGG
A AAATTACCTT CTTTCTTTTT CCTTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCC
ATTTAT TCCATTGATC TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT
GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAAT
GGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT
CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTTCCCC CTCAAA
CACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC AATTTGTAAG T
ATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG TGCTTTTCTA CCTGGAT
CAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC TCATTCAACA AGCATTATTC AC
TGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA GTGTGGACAG TGGTGCATCA AAGCCTCT
AG TCTCATAGAA CTTAGTCTTC TGGAGGATAT GGAAAACAGA CAACCCAAAC AACCAACAAA AGA
GCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTA
T TTAGACAAAG TGGTAAAAAC AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTC
ATGGTT GTGGGTTTTT GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG GTTTTTGGGT
AGGACATTCA GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGG
GCGGG TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT
TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG ACAGCT
CCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTGAGA AGGAGGAAAA ATATGCAGAG A
CTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA ACCCATTAAT GGGTTTC
ACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG AAAACAGATC AGAAGGAAGG CA
ATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAA
GT GGAAAGAAAC AGACAGAATT GGGTTATATT TTGGAGATAG AACCAACAGA AGGAAGAGGA GAA
ACAACAT TTACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACAT
T GGAAACCCCA AGGAAGCCTC AAAAGTATAT TTACTTGCTT TAGATTTAAA AGAATAGGAA AGAA
GCATCT CAACTTGGAA TTTGAAATCT ATTTTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA
CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATTTT GTGTG
TATGT GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCAATTG TTGACTTAAA TACTGAGATA
AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA AATGTT
TAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTTAGGCC TATGTTGAAG G
CAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CAGTAAGATA CTAGTGTCAC TGACAAT
CTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT CAACTCTTAT TAATAGACTG GG
CCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA TGAACAAATG AATGAAGAGC CTATAGCA
TC ATGTTACAGC CATAGTCCTA AAGTGGTGTT TCTCATGAAG GCCAAATGCT AAGGGATTGA GCT
TCAGTCC TTTTTCTAAC ATCTTGTTCT CTAACAGAAT TCTCTTCTTT TCTTCATAGG AGATGCCTG
A GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACT
AAGAAC TATTTCACAT CAGTTGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG
TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTG
GAGTC TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA
AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG TTTACA
CTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA CCCTATATTT T
GCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA ATTTTAGGAG GACCAGAGCT ACTGACT
ATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT TAAGGCATAA GAAAACTAAG AA
ATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC TAGGATTTCA TGATTTCATT TCAACTGT
TT GCCTTCTGCT TTTAAGTTGC TGATGAACTC TTAATCAAAT AGCATAAGTT TCTGGGACCT CAG
TTTTATC ATTTTCAAAA TGGAGGGAAT AATACCTAAG CCTTCCTGCC GCAACAGTTT TTTATGCTA
A TCAGGGAGGT CATTTTGGTA AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGA
AATGTT ATTTTTTAAT TATTATTTAT ATATGTATTT ATAAATATAT TTAAGATAAT TATAATATAC
TATATTTATG GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTG
TTTTC TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCATTTT GGTCCAAGTT GTGCTTATCC
CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA CATTAA
TTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTGCCA TTAAACTTAC CTGGGCATTC T
TGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA TGAACTCAAC TTTGACA
ACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA ATCAATGTTT CTTCTAGGTT CT
AAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA ACAATAGTGA TTGATAGAGT GTTATCAG
TC ATAACTAAAT AAAGCTTGCA ACAAAATTCT CTGACACATA GTTATTCATT GCCTTAATCA TTA
TTTTACT GCATGGTAAT TAGGGACAAA TGGTAAATGT TTACATAAAT AATTGTATTT AGTGTTACT
T TATAAAATCA AACCAAGATT TTATATTTTT TTCTCCTCTT TGTTAGCTGC CAGTATGCAT AAAT
GGCATT AAGAATGATA ATATTTCCGG GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG
TTCCCATCTT TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACG
GTGGC TCAGACCTGT AATCCCAGCA CTTTGGGAGG ACCAACCTCT TCGAGGCACA AGGCACAACA
GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAG
TACC TGAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA A
GCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGC
ATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GT
GGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAG
CA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTT
ATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGG
T GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTG
GTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC
AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAG
TGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA
TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAG
AAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA A
TTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGG
GCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT AC
ACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGT
CA GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTGA GCCAGGCCTC TCTCACCTCT CCT
ACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT CTGTCATTC
G CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA TTTATTTGTT TGTTTGTTTT ATTC
ATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA AAAGAGCCTA GTTTTTAATA
GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT AAATCAAGTC CTTTAATTAA GACTG
AAAAT ATATAAGCTC AGATTATTTA AATGGGAATA TTTATAAATG AGCAAATATC ATACTGTTCA
ATGGTTCTGA AATAAACTTC TCTGAAG AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGA
A GGAAGGAAGG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGG
TTAATT TGCAAAGTGG ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTT
TTAGCTATCT GCAGGCCAGA CACCAAATTT CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCTT
ATCAA ATTCACAGGA AACTAACATG TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC
TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA TCAGAA
GGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TTTCCCACAG TAGAACCTAT TTCCCTCGTG T
CTCAAATAC TTGCACAGAG GCTCACTCCC TTGGATAATG CAGAGCGAGC ACGATACCTG GCACATA
CTA ATTTGAATAA AATGCTGTCA AATTCCCATT CACCCATTCA AGCAGCAAAC TCTATCTCAC CT
GAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA AAAGATTTCA GTTTCCTGGA GGAACCAG
GA GGGCAAGGTT TCAACTCAGT GCTATAAGAA GTGTTACAGG CTGGACACGG TGGCTCACGC CTG
TAATCCC AACATTTGGG AGGCCGAGGC GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGC
T AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGC
CTGTAG TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC
AGGGGGCCGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAA
AAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC
ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAG
CAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTGGTATTAC CAAGAGATAG A
GTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TTTCAGAGTT CACCAAAAAA TCATTTT
AGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGATT GGCTAGGGTA ACAGCACCTG GT
CTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCAT
AC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACA
GAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGG
G CTATTGGCCC TTCATTGTAC CCATTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTAC
AAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA
TACTAAATTT AAACATTCTT CTAACGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCAC
AACGA TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG
CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA GAAGCT
TCCA CCAATACTCT TTTCCCCTTT CCTTTAACTT GATTGTGAAA TCAGGTATTC AACAGAGAAA T
TTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA GATACCA
AAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATTC TCTTCAGCCA ATCTTCATTG CT
CAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT GCCTCTTT
GT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGC
CTCCTCT CTCAGCTTTT TGCAAAAATG CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCT
G GGAATGGATA CTGCTTATCT AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAG
CTCTCC TAGCCAATAC ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG
ACTTCTCTTT CACACATTCA TTCATTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTG
GATGC TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA
CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACA
GGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT AGAGTGTTAT C
TGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA ACAGGGTGCC AAGTAAA
TCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGCCT TGGGACCTGG AGGCTATCCA GA
TGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG AGAAAAGATT CCAAGCCCAC AATACAAG
GA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGG
GCTAGAG GTTAGGCCTC AAGATCCAAC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCT
G CCTTCTGGAC TGTTCTGCGC ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAG
GCAGGC TGTTTGCAGT TTCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT
TTAGAAGACA TAATTGAGAC ATGTCCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTT
TGAAG CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG
CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT TGTTTT
AGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTTGGT C
ATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTT GGTGGTGACA GGGGAGG
AGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCAAG TCTTCAACAT AAATTTGATT AT
CCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG AGTTAAACTC TGAAACCAAG AGATGATC
TT GAGAACTAAC ATATGTCTAC CCCTTTTGAG TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTT
ATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACT
T GCTGTTTGAC CTTGACAAGT CATTTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAG
CTGGAT GATCTCTGAG ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA
AGGGCATTTG GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCC
TGCTG TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCTAGGT GCCCAGCCAT CAGCCTAGCT
AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG TGATAG
CCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA GAAGTTTTAA G
ACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT CTGCCTGGCC TTTGCCC
CCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA ATTCTCTCCT GCTCAACTTT CT
TTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC CTTTGAACCA TTATCAGCCT TAAGGCAA
CC TCAGTGAAGC CTTAATACGG AGCTTCTCTG AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAG
TACTCTC ACAGGATTTG CAGAATGCCT ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTG
T AGAAAAATTG AATACTTGCT GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGA
AAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG
TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGT
AAGGT GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA
CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT GTTTTG
TTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA GTGCAGTGGT A
CAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTCAA GCGATTCTCC TTCCTCAGTC TCCTGAA
TAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATTTT TGTATTTTTA GTAGAGAAGG GG
TTTCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC CTAAATGATT CATCCACCTC GGCTTCCC
AA AGTGCTGGGA TTACAGGCAT GAGCCACCAC GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCT
CGGGATT CTTTCAAGCC CTTTCCTCCT CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCC
T GGCAGGACCA CCTCACCAGG CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGA
CCTCTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG
GCAGGCCGCG TCAGTTGTTG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGA
CCTTC CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA
GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCC
AGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC A
AAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG CTACTGACAT TTGCAAC
TCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA GAGGTTCGTA ACCTCCCTGT GG
GCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT CTGTTGCTCG GCCACAGTGA GCAGTAAT
AG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCA
GCTTCAT CCCTACTGGT GTTGTCATCA GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATC
A AATTTTGCCA CCTCGCCTCA CGAGGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCC
ACATTT CAGAACCTAT CTTCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC
GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAA
CTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT
CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA ATTTAA
GGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT GGTCCTAGAA A
TGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC CCTGAGAAAT TAGACGG
CTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA TAGTGCAGTG TCAATTCTTC CA
CAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT GTGGGTTCTC TCTTCCTGTT GTTGAGGC
TG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAA
CATCCGT CCCACCCAAT GCCAGGTGGT TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATA
T CTCTCCGCTG TAACGGGCAA AAGTTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGC
CTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT
GAAGGACAGC CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTT
TGGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA
AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT CCCATG
GGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTCTGG CAGAAGTACA GCTTCACCTC T
TTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA CATTGCCAGC CAGTGAC
ACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG ACCCTCTTTC ATTCTCCGTT CC
TACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA GGGGAAACCC TAAATCAACA AAATGACC
CT GCTATTGTCT GTGAGAAGTC AAGTTATCCT GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTC
CCACAGA GGCTACCAAT TACATGTATC CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCT
G TGTCCCTAAC CACAAGACCC CCTTCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAG
AAGAAA GTAATGACAA AATACCTGTG GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG
TGTTGAAAGA TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTC
TCAGC CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA
GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA AATAAATTTA ACATAATTTT TAACTG
CGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTTGCC GATGTTATTA TGTCCTACCA T
AGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCATTTGAT AGACACCTTG GGAAATA
GAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA AATCACCACC ACTATCACCT CC
AGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC ATTCTAGGAC CATAAGGAAA AATACAAT
AA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAA
AAAATTC TCACCTACAT TATGCTCCTC AGCATTTGGC ACTAAGTTTT AGAAAAGAAG AAGGGCTCT
T TTAATAATCA CACAGAAAGT TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTG
ACCTGC TCGTCAGTTT CCTTTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT
TGCCCCACAA AAATTCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAA
GAAGA TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG
CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG GAGGGA
CCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGTG TCTTCCTAAA GAGAGCTGTA C
CCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGGTTT
TTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACCAA TGCCCAACTG CCTGCCTTAG GG
TAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCAGCTCTCT CCTTTCAGGG CCAATCCC
CA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAA
CCACGGC CACATTTGGT TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCT
T CCCTATTTAT TTATTTATTT GTTTGTTTGT TTTGATTCAT TGGTCTAATT TATTCAAAGG GGGC
AAGAAG TAGCAGTGTC TGTAAAAGAG CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGGACT
GGTGTGCTCT CTTTAAATCA AGTCCTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAA
ATGGG AATATTTATA AATGAGCAAA TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA
GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC AAACAG
GCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA CCTAGAAATA T
CCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TATTTCGTTG TTCAACAGAA GGATATT
CAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TCAGGACTGG TAGTAACAGC TA
CCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGT
AC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACA
AGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAA
C GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGG
TGTCGG TTACGCCTGT AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA
GTTCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAA
AACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG
GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA C ACAA
ACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCAATGCTCA
AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTG
GCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC
CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGC
TTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC C
ACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTT
CTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GC
TCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCC
AG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AAT
GACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGAT
G ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAA
GCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA
CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCC
AGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT
GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCT
ATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA G
GATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTT
GAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TT
TGGTTCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTA
TT TATTTATTTG TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGC
AGTGTCT GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCT
C TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA ATAT
TTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT CTGGCAGGAG TAG
CAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCA
A CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTTCGCT TGCCGTCCAC CACT
GCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG ATCCGGCAAG
GGCCTGCGAT TTTGACAATG TCAAGATTTA CCGTATATCC CTGTTTGTTT GGATACACCA GTGAC
GTCCA CTTCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA
ACAATATTAT CAATACACAG CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAA
AGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC T
ACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGA
AAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC AA
CAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTC
AG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA ATGGCCAAAG TTC
CAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA GACAGTTCCT CCATTGATC
A TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT GGCCCACTCC ATGAAGGCTG CATG
GATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCTTACCTT CAAGGAGAGC
ATGGTGGTAG TAGCAACCAA CGGGAAGGTT CTGAAGAAGA GACGGTTGAG TTTAAGCCAA TCCAT
CACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG
CACCTTTTAG CTTCCTGAGC AATGTGAAAT ACAACTTTAT GAGGATCATC AAATACGAAT TCATCC
TGAA TGACGCCCTC AATCAAAGTA TAATTCGAGC CAATGATCAG TACCTCACGG CTGCTGCATT A
CATAATCTG GATGAAGCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAA
ATT ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCAAGA TGAAGACCAA CC
AGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC CTCCTCTT
CT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA AACTTGTTTA TTG
CCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATCACTGACT TTCAGATAC
T GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT TGTGCAGTGT TGACAGTTCA TATG
TACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT AGTCATTTGC TGAGCATGTA CTGAGCCTTG
TAATTCTAAA TGAATGTTTA CACTCTTTGT AAGAGTGGAA CCAACACTAA CATATAATGT TGTTA
TTTAA AGAACACCCT ATATTTTGCA TAGTACCAAT CATTTTAATT ATTATTCTTC ATAACAATTT
TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC TCTACCCATA TTACAGATGG GCAAAT
TAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACCTAGG A
TTTCATGAT TTCATTTCAA CTGTTTGCCT TCTGCTTTTA AGTTGCTGAT GAACTCTTAA TCAAATA
GCA TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA GGGAATAATA CCTAAGCCTT CC
TGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT ACTTCTCGAA GCCGAGCC
TC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTATT ATTTATATAT GTATTTATAA ATA
TATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC CTCTGAGTGT GACCAGGCA
T CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT TTGATTTCAT TAATACAGGG CATT
TTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGCATTCT AGTACTTGGG AGACCTGTAA
TCATATAATA AATGTACATT AATTACCTTG AGCCAGTAAT TGGTCCGATC TTTGACTCTT TTGCC
ATTAA ACTTACCTGG GCATTCTTGT TTCATTCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA
ATTAGATGAA CTCAACTTTG ACAACCATAG ACCACTGTTA TCAAAACTTT CTTTTCTGGA ATGTAA
TCAA TGTTTCTTCT AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACATTAT TATCAACAAT A
GTGATTGAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA GGGAGTCATT TCATTGG
CGT TTGAGTCAGC AAAGAAGTCA AG AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTTGA
GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAG
TGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG
TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCT
CTAA AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT G
AAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGAC
TCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA TGTGAAATAC AA
CTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA TCAAAGTATA ATTCGAGC
CA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA TGAAGCAGTG AAATTTGACA TGG
GTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC CGTGATTCTA AGAATCTCAA AAACTCAAT
T GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAA
ACCATC ACAGGTAGTG AGACCAACCT CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC
ACATCAGTTG CCCATCCAAA CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGG
GGGGC CACCCTCTAT CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT
GTCTCACTTG TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTG
TTAG TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA G
AGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA GTACCAA
TCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC TATGGCTACC AA
AAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC TAAGAAATAT GCACAATA
GC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT CATTTCAACT GTTTGCCTTC TGC
TTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA AGTTTCTGGG ACCTCAGTTT TATCATTTT
C AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGT
CATTTT GGTAAAATAC TTCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT
TAATTATTAT TTATATATGT ATTTATAAAT ATATTTAAGA TAATTATAAT ATACTATATT TATGG
GAACC CCTTCATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT
AAGTAAGTTT GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAA
ACTC TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG C
CAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT CATTCAA
TTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC AACCATGAGA CC
ACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTTTCTTCTA GGTTCTAAAA ATTGTGAT
CA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA GAGTGTTATC AGTCATAACT AAA
TAAAGCT TGCAACAAAA TTCTCTG GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG C
TGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTG
CCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TG
AGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGAC
CC TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCT
GGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCT
G GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGG
ACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC
TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTG
ATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC
CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTG
GGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT C
CTTCCAAAG CCAGATCTTA TTTATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCC
CCC GCCATTATCT CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TT
ATTTATAC TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGA
GG GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TCT
TCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT GTTGGGGTG
G GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGA
GAACAG GGAATTAAAT GTGTCATACA TATCC CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTG
TCTCTG TTCCTTTCCC CTCGGGGTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG
CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTT
GCTTC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT
CAGTCTGTCC TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCT
CTTC CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT T
CCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGG
CCC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG AC
CTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTT TTCAACTTTT CCAACTTTTC CTTCCGTG
CC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAG
GCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGC
C CCAGGCCCCC TATATAACCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCA
GGGCAC ATGCCTCCCC TCCCCAGCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA
GGGAAGGGTT AAAGGCCCCC GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGAC
ATGAA CTGTAAGTTG GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA
CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGA
GGAG AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC G
GATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGA
CGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CC
CAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGG
AA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGG
AGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACA
G ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCG
CTGATT GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG
ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCC
GGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC
GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCT
GGGC TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG G
TTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACG
GGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AG
CCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCC
TC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGG
CCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC CTCTCCTCCC TCAGACCCAG GAGGAGTCC
A GACCCCAGTT CCTCCTCCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGA
GTCCAG CCTGAGCTCT CTGCCTTATC CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA
GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGAC
CCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT
GGCTGCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGG
AGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG G
AAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGC
TTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC AC
CCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAA
GG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTTCTCTGA TGT
CCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGC
G GCACGTGCAG TGGCTGCGCC GGGCAGGTGG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGC
ACCCTG CAGGCCCGAC TGGACCGGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG
ACCTGACACC CCAGACCCCC ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAG
ACCCC AGACCCGAGT GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC
CCTGACACCG TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCC
TGCA GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA A
CTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGC
CCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC TCACCTCAAG AC
TTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGT
AA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCA
GACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCC
T GTAATCCCAG CTACTTGGGA GGCTGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGC
AGTGAG CCGAGATCGC ACCATTACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA
AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAG
GCCCC AGCCCTGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA
AGCCAGCCTT GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGG
CCCT ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG A
CTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGTT
CTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA GACTCCAGCC CT
CACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT TCAGCCTTGA GATCCAGG
GC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGG
AGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCAT
G AGTTTGAGAC AGCCTGGGCA GCATAGCAAG ACTCTGTTTC TTAATTATTA TTATTATTAT TATT
TTTTGG AGACAGAGTC TCGCGCTCTG TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT
GGAACCTCCG CCTCCTGGGC TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCA
GGTGC ACACTGCCAC ACCCGGATAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG
CCCAGGCTGG TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGA
TAAC AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC C
AGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGA
TGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GA
CTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGC
GC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA GCTCCACAGC ACCCCTGCCC TGC
ACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTGGCCC
T GCCCCAGCCA CCCCCGGACC CGCCGGCGCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGC
ATCAGG GCCGCCCACG CCATCCTGGG GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG
CTGCTGCTGA AGACTCGGCT GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATC
TTATT TATTTATTTA TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC
CCCTAGTTAG AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTAT
TTCA GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC C
GGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT AGGCCTG
GGC AGGAACATAT ATTATTTATT TAAGCAATTA CTTTTCATGT TGGGGTGGGG ACGGAGGGGA AA
GGGAAGCC TGGGTTTTTG TACAAAAATG TGAGAAACCT TTGTGAGACA GAGAACAGGG AATTAAAT
GT GTCATACATA TCCACTTGAG GGCGATTTGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGG
GGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGG
G AGATGGGTCG GTCACCCAGA CAGCTCTGTG GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCA
CTGCAT AGGGCCGTTT GTTTGTTTTT TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG
TGAGGCAATC TAAGGTCACT GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCT
CCCGA TTAGCTGGGA TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT
TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCC
TCCT GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT C
TTCAATAAA TATTTAATGG AAGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAA
AGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA AACAATCTAG AT
ATCCAACA GTGAGGGTTA AGCAACATGG TGCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGC
AG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG GGATATAGAA AGATATCCTG ACA
TTGGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC ACTTTGGGAG GACGAAGCGA GTGGATCAC
T GAAGTCCAAG AGTTTGAGAC CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAA
TGATGT CCTGACATGA AACAGCAGGC TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT
TCTTTCTATA TATGGATTAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACT
GTCTC CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT
TTACAGAATT TCTGCCATGA CTGTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTT
TAGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA C
CGCTGATTG AGCCTGTCAG GGCTGTGCAC-3' (配列番号3004) ヒトアデノシンA1レセプター核酸およびアンチセンスオリゴヌクレオチドフラ グメント 5'-ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTG
GTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCC
A CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCT
CGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT
CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGG
TCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC
TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGG
AGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TC
ATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATG
GT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTC
CTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCT
C TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGT
CCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA
ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGAC
CATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA
G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGG
CTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG
TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACC
TTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA
GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGG
GACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT G
TGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGA
GGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CC
AGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTG
CC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTC
ATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTG
G ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGC
GGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA
CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGT
GCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG
CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAAC
AAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA A
GTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCAT
CAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GC
ACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCC
TT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAA
GAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCC
A GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGG
GGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT
ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGA
GGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG
GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTC
TGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA A
GGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCT
GTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GA
GGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAG
GA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGC
TGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGT
A GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCA
TCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG
CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCT
GGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG
GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGC
TGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG T
TGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTG
CCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GC
GAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCG
GG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTT
GCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGAC
T AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTT
GAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT
TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGA
TGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC
CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGA
AGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG G
TGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCC
ATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GT
CTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCAC
CT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCG
CCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCC
T CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTC
AAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC
TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGA
GCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA
TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGG
TCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC C
TCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTC
TTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TC
CTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAA
CC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACC
ATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGA
C CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTG
TCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA
GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAG
GAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC
CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTG
AGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG T
CTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTC
TGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA
GAT GGA GGG CGG CAT GGC GGG G CGG GTC GCC GG GGC GGG CBC BGG C GGC GGG
CBC GC GGC CTG G GGB GGG CGG C GBT GGB GGG GG CTG GGC GC GGC CTG GAA AGC
TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC ATGCCGCCCT CCATCTCAGC T
TTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTG
GTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CT
GGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCC
AC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCA
TCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGA
T GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTG
GGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC
AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTA
CTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT
TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACT
ATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG G
CTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTT
ACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CG
CATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACC
TC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA G
GGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAA
CCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GA
CAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGC
GG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGC
GGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAG
G ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGC
CGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG
TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTC
TGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT
CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCAT
CCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG A
TCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGA
TCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GG
GCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGC
AT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCT
CATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGG
C GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCC
TCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC
ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCC
ATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT
CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCC
GCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC C
CAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAG
ATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AG
GCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCA
CC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGA
CTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGC
T TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGA
GACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA
GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATAC
CAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA
AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGA
GCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG C
CCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGC
CCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GA
GGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGT
GT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCA
GAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACC
C CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGA
CTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG
GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCC
TGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG
CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTT
GGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT C
GCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAA
TTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TT
TGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGG
AG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCC
GGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACT
T GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTG
CCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT
CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGG
TGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG
GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCA
CAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA T
CCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGAT
GGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GG
GACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCA
GC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TAC
TTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTC
T ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTA
TGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT
GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTA
CCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC
ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCT
CCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG C
CCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTG
CCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TC
CCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCC
TA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATG
AGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGG
C TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGG
TGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG
TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3'(フラグメント番号 )(配列番号3005) [2423)] 5'-CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGG
AAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTT
G TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTAC
CGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG
GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGG
CACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT
CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAG
CTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT G
CTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCG
CTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GG
GCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTC
CA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACA
AGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGG
T GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAAC
GGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC
TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGT
CTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT
ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCT
GGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT C
CTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTC
CGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GC
ACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCAC
CG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAG
CCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTG
G TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGG
GTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC
ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACC
TGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG
GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGA
GAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3' (フラグメント番
号 )(配列番号2434) 5'- ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GA
GGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGG
CG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGA
CCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAG
A GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCT
GGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT
GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATC
GAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA
CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGG
TGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC C
TCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTG
TGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CG
GCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGG
AA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAA
GTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCT
G CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCA
ACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA
AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGC
ATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC
GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTT
CCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA G
AAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGT
CCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TG
GGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACC
CT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTA
GAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCT
G GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCT
TCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA
AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTT
CTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT
GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCC
AGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG T
GCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTG
GTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GT
CATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTC
TG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGC
CTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGT
G GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTT
GCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG
TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCC
TGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG
GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGT
CGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA C
TTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTG
ACT AATAAAAAAC TGTGAACCCT -3' (フラグメント番号 )(配列番号2433) 5'- ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CT
GGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGC
CA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCC
TCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGG
T CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGG
GTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC
TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGT
GGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG
TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCA
TGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC C
TCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATC
CTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CC
GTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCAT
GA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATG
ACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACT
A G-3' (フラグメント番号 )(配列番号2432) 5'-CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGG
AAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTT
G TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTAC
CGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG
GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGG
CACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT
CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAG
CTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT G
CTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCG
CTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GG
GCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTC
CA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACA
AGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGG
T GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAAC
GGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC
TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGT
CTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT
ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCT
GGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT C
CTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTC
CGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GC
ACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCAC
CG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAG
CCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTG
G TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGG
GTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC
ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACC
TGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG
GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGA
GAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3' (フラグメント番
号 )(配列番号2422) 5'-ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAG
GCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGC
G TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGAC
CTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA
GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTG
GGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT
GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCG
AGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA C
CAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGT
GCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CT
CATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGT
GG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGG
CGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGA
A CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAG
TGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG
CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAA
CAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA
AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCA
TCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC G
CACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTC
CTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GA
AGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTC
CA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGG
GGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCC
T ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAG
AGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG
GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTT
CTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA
AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTC
TGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT G
AGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCA
GGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TG
CTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGG
TA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTC
ATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCT
G CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCC
TGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG
GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTG
CTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG
TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCT
GCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG G
CGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTC
GGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CT
TGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGA
CT AATAAAAAAC TGTGAACCCT -3' (フラグメント番号 ) (配列番号2421) 5'-ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTG
GTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCC
A CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCT
CGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT
CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGG
TCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC
TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGG
AGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TC
ATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATG
GT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTC
CTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCT
C TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGT
CCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA
ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGAC
CATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA
G (フラグメント番号 ) (配列番号2420) 5'-GAT GGA GGG CGG CAT GGC GGG-3' (フラグメント番号1657) (配列番号2412)
5'-G CGG GTC GCC GG-3' (フラグメント番号1658) (配列番号2413) 5'-GGC GGG CBC BGG C-3' (フラグメント番号1659) (配列番号2414) 5'-GGC GGG CBC-3' (フラグメント番号1660) (配列番号2415) 5'-GC GGC CTG G-3' (フラグメント番号1661) (配列番号2416) 5'-GGB GGG CGG C-3' (フラグメント番号1662) (配列番号2417) 5'-GBT GGB GGG-3' (フラグメント番号1663) (配列番号2418) 5'-GG CTG GGC-3' (フラグメント番号1664) (配列番号2419) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'
(フラグメント1) (配列番号11) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'(
フラグメント2) (配列番号12) 5'-GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'(フ
ラグメント3)(配列番号13) 5'-GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フ
ラグメント4)(配列番号14) 5'-C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フ
ラグメント5) (配列番号15) 5'-CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラ
グメント6) (配列番号16) 5'-TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグ
メント7) (配列番号17) 5'-G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグ
メント8) (配列番号18) 5'-GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメ
ント9) (配列番号19) 5'-AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメン
ト10) (配列番号20) 5'-A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメン
ト11) (配列番号21) 5'-AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント1
2) (配列番号22) 5'-GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント13
) (配列番号23) 5'-C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント14)
(配列番号24) 5'-TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント15) (
配列番号25) 5'-GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント16) (
配列番号26) 5'-A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント17) (配
列番号27) 5'-GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント18) (配列
番号28) 5'-AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント19) (配列
番号29) 5'-T GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント20) (配列番
号30) 5'-GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント21) (配列番号
31) 5'-GA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント22) (配列番号3
2) 5'-A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント23) (配列番号33
) 5'-GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント24) (配列番号34)
5'-GG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント25) (配列番号35) 5'-G CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント26) (配列番号36) 5'-CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント27) (配列番号37) 5'-GG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント28) (配列番号38) 5'-G CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント29) (配列番号39) 5'-CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント30) (配列番号40) 5'-AT GGC GGG CAC AGG CTG GGC-3' (フラグメント31) (配列番号41) 5'-T GGC GGG CAC AGG CTG GGC-3' (フラグメント32) (配列番号42) 5'-GGC GGG CAC AGG CTG GGC-3' (フラグメント33) (配列番号43) 5'-GC GGG CAC AGG CTG GGC-3' (フラグメント34) (配列番号44) 5'-C GGG CAC AGG CTG GGC-3' (フラグメント35) (配列番号45) 5'-GGG CAC AGG CTG GGC-3' (フラグメント36) (配列番号46) 5'-GG CAC AGG CTG GGC-3' (フラグメント37) (配列番号47) 5'-G CAC AGG CTG GGC-3' (フラグメント38) (配列番号48) 5'-CAC AGG CTG GGC-3' (フラグメント39) (配列番号49) 5'-AC AGG CTG GGC-3' (フラグメント40) (配列番号50) 5'-C AGG CTG GGC-3' (フラグメント41) (配列番号51) 5'-AGG CTG GGC-3' (フラグメント42) (配列番号52) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3
'(フラグメント43)(配列番号53) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3'
(フラグメント44)(配列番号54) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3'
(フラグメント45)(配列番号55) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (
フラグメント46)(配列番号56) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フ
ラグメント47)(配列番号57) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フ
ラグメント48)(配列番号58) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラ
グメント49) (配列番号59) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグ
メント50) (配列番号60) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグ
メント51) (配列番号61) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメ
ント52) (配列番号62) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメン
ト53) (配列番号63) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメン
ト54) (配列番号64) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント
55) (配列番号65) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント56
) (配列番号66) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3'(フラグメント57)
(配列番号67) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント58)
(配列番号68) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント59) (
配列番号69) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント60) (
配列番号70) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント61) (配
列番号71) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント62) (配列
番号72) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント63) (配列番
号73) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント64) (配列番
号74) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (フラグメント65) (配列番号
75) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG C -3' (フラグメント66) (配列番号7
6) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG -3' (フラグメント67) (配列番号77)
5'-GGC GGC CTG GAA AGC TGA GAT GGA GG -3' (フラグメント68) (配列番号78)
5'-GGC GGC CTG GAA AGC TGA GAT GGA G -3' (フラグメント69) (配列番号79) 5'-GGC GGC CTG GAA AGC TGA GAT GGA -3' (フラグメント70) (配列番号80) 5'-GGC GGC CTG GAA AGC TGA GAT GG -3' (フラグメント71) (配列番号81) 5'-GGC GGC CTG GAA AGC TGA GAT G -3' (フラグメント72) (配列番号82) 5'-GGC GGC CTG GAA AGC TGA GAT -3' (フラグメント73) (配列番号83) 5'-GGC GGC CTG GAA AGC TGA GA-3' (フラグメント74) (配列番号84) 5'-GGC GGC CTG GAA AGC TGA G-3' (フラグメント75) (配列番号85) 5'-GGC GGC CTG GAA AGC TGA-3' (フラグメント76) (配列番号86) 5'-GGC GGC CTG GAA AGC TG-3' (フラグメント77) (配列番号87) 5'-GGC GGC CTG GAA AGC T-3' (フラグメント78) (配列番号88) 5'-GGC GGC CTG GAA AGC-3' (フラグメント79) (配列番号89) 5'-GGC GGC CTG GAA AG-3' (フラグメント80) (配列番号90) 5'-GGC GGC CTG GAA A-3' (フラグメント81) (配列番号91) 5'-GGC GGC CTG GAA-3' (フラグメント82) (配列番号92) 5'-GGC GGC CTG GA-3' (フラグメント83) (配列番号93) 5'-GGC GGC CTG G-3' (フラグメント84) (配列番号94) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'
(フラグメント85) (配列番号95) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3'
(フラグメント86) (配列番号96) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (
フラグメント87) (配列番号97) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (
フラグメント88) (配列番号98) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フ
ラグメント89) (配列番号99) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラ
グメント90) (配列番号100) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラ
グメント91) (配列番号101) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグ
メント92) (配列番号102) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメ
ント93) (配列番号103) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメン
ト94) (配列番号104) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメン
ト95) (配列番号105) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント
96) (配列番号106) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント9
7) (配列番号107) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント98)
(配列番号108) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント99)
(配列番号109) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント100)
(配列番号110) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント101) (
配列番号111) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント102) (
配列番号112) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント103) (配
列番号113) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント104) (配列
番号114) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント105) (配列番
号115) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント106) (配列番
号116) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (フラグメント107) (配列番号
117) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG C -3' (フラグメント108) (配列番号1
18) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG -3' (フラグメント109) (配列番号119
) 5'-GC GGC CTG GAA AGC TGA GAT GGA GG -3' (フラグメント110) (配列番号120)
5'-GC GGC CTG GAA AGC TGA GAT GGA G -3' (フラグメント111) (配列番号121)
5'-GC GGC CTG GAA AGC TGA GAT GGA -3' (フラグメント112) (配列番号122) 5'-GC GGC CTG GAA AGC TGA GAT GG -3' (フラグメント113) (配列番号123) 5'-GC GGC CTG GAA AGC TGA GAT G -3' (フラグメント114) (配列番号124) 5'-GC GGC CTG GAA AGC TGA GAT -3' (フラグメント115) (配列番号125) 5'-GC GGC CTG GAA AGC TGA GA-3' (フラグメント116) (配列番号126) 5'-GC GGC CTG GAA AGC TGA G-3' (フラグメント117) (配列番号127) 5'-GC GGC CTG GAA AGC TGA-3' (フラグメント118) (配列番号128) 5'-GC GGC CTG GAA AGC TG-3' (フラグメント119) (配列番号129) 5'-GC GGC CTG GAA AGC T-3' (フラグメント120) (配列番号130) 5'-GC GGC CTG GAA AGC-3' (フラグメント121) (配列番号131) 5'-GC GGC CTG GAA AG-3' (フラグメント122) (配列番号132) 5'-GC GGC CTG GAA A-3' (フラグメント123) (配列番号133) 5'-GC GGC CTG GAA-3' (フラグメント124) (配列番号134) 5'-GC GGC CTG GA-3' (フラグメント125) (配列番号135) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'
(フラグメント126) (配列番号136) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (
フラグメント127) (配列番号137) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (
フラグメント128) (配列番号138) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フ
ラグメント129) (配列番号139) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラ
グメント130) (配列番号140) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラ
グメント131) (配列番号141) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグ
メント132) (配列番号142) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメ
ント133) (配列番号143) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメ
ント134) (配列番号144) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメン
ト135) (配列番号145) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント
136) (配列番号146) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント1
37) (配列番号147) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント13
8) (配列番号148) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント139)
(配列番号149) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント140)
(配列番号150) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント141) (
配列番号151) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント142) (
配列番号152) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRA 143) (配列番号15
3) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント144) (配列
番号154) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント145) (配列番
号155) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント146) (配列番
号156) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント147) (配列番号
157) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (フラグメント148) (配列番号1
58) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG C -3' (フラグメント148) (配列番号15
9) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG -3' (フラグメント150) (配列番号160)
5'-C GGC CTG GAA AGC TGA GAT GGA GG -3' (フラグメント151) (配列番号161)
5'-C GGC CTG GAA AGC TGA GAT GGA G -3' (フラグメント152) (配列番号162) 5'-C GGC CTG GAA AGC TGA GAT GGA -3' (フラグメント153) (配列番号163) 5'-C GGC CTG GAA AGC TGA GAT GG -3' (フラグメント154) (配列番号164) 5'-C GGC CTG GAA AGC TGA GAT G -3' (フラグメント155) (配列番号165) 5'-C GGC CTG GAA AGC TGA GAT -3' (フラグメント156) (配列番号166) 5'-C GGC CTG GAA AGC TGA GA-3' (フラグメント157) (配列番号167) 5'-C GGC CTG GAA AGC TGA G-3' (フラグメント158) (配列番号168) 5'-C GGC CTG GAA AGC TGA-3' (フラグメント159) (配列番号169) 5'-C GGC CTG GAA AGC TG-3' (フラグメント160) (配列番号170) 5'-C GGC CTG GAA AGC T-3' (フラグメント161) (配列番号171) 5'-C GGC CTG GAA AGC-3' (フラグメント162) (配列番号172) 5'-C GGC CTG GAA AG-3' (フラグメント163) (配列番号173) 5'-C GGC CTG GAA A-3' (フラグメント164) (配列番号174) 5'-C GGC CTG GAA-3' (フラグメント165) (配列番号175) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (
フラグメント166) (配列番号176) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (
フラグメント167) (配列番号177) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フ
ラグメント168) (配列番号178) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フ
ラグメント169) (配列番号179) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラ
グメント170) (配列番号180) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグ
メント171) (配列番号181) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグ
メント172) (配列番号182) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメ
ント173) (配列番号183) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメン
ト174) (配列番号184) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント
175) (配列番号185) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント1
76) (配列番号186) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント17
7) (配列番号187) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント178
) (配列番号188) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント179)
(配列番号189) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント180) (
配列番号190) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント181) (
配列番号191) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント182) (配
列番号192) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント183) (配
列番号193) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント184) (配列
番号194) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント185) (配列番
号195) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント186) (配列番号
196) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント187) (配列番号1
97) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (フラグメント188) (配列番号19
8) 5'- GGC CTG GAA AGC TGA GAT GGA GGG C -3' (フラグメント189) (配列番号199
) 5'- GGC CTG GAA AGC TGA GAT GGA GGG -3' (フラグメント190) (配列番号200)
5'- GGC CTG GAA AGC TGA GAT GGA GG -3' (フラグメント191) (配列番号201) 5'- GGC CTG GAA AGC TGA GAT GGA G -3' (フラグメント192) (配列番号202) 5'- GGC CTG GAA AGC TGA GAT GGA -3' (フラグメント193) (配列番号203) 5'- GGC CTG GAA AGC TGA GAT GG -3' (フラグメント194) (配列番号204) 5'- GGC CTG GAA AGC TGA GAT G -3' (フラグメント195) (配列番号205) 5'- GGC CTG GAA AGC TGA GAT -3' (フラグメント196) (配列番号206) 5'- GGC CTG GAA AGC TGA GA-3' (フラグメント197) (配列番号207) 5'- GGC CTG GAA AGC TGA G-3' (フラグメント198) (配列番号208) 5'- GGC CTG GAA AGC TGA-3' (フラグメント199) (配列番号209) 5'- GGC CTG GAA AGC TG-3' (フラグメント200 (配列番号210) 5'- GGC CTG GAA AGC T-3' (フラグメント201) (配列番号211) 5'- GGC CTG GAA AGC-3' (フラグメント202) (配列番号212) 5'- GGC CTG GAA AG-3' (フラグメント203) (配列番号213) 5'- GGC CTG GAA A-3' (フラグメント204) (配列番号214) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (
フラグメント205) (配列番号215) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フ
ラグメント206) (配列番号216) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フ
ラグメント207) (配列番号217) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラ
グメント208) (配列番号218) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグ
メント209) (配列番号219) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグ
メント210) (配列番号220) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメ
ント211) (配列番号221) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメン
ト212) (配列番号222) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメン
ト213) (配列番号223) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント2
14) (配列番号224) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント21
5) (配列番号225) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント216
) (配列番号226) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント217)
(配列番号227) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント218) (
配列番号228) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント219) (
配列番号229) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント220) (配
列番号230) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント221) (配
列番号231) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント222) (配列
番号232) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント223) (配列番
号233) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント224) (配列番号
234) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント225) (配列番号2
35) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント226) (配列番号23
6) 5'- GC CTG GAA AGC TGA GAT GGA GGG CG -3' (フラグメント227) (配列番号237
) 5'- GC CTG GAA AGC TGA GAT GGA GGG C -3' (フラグメント228) (配列番号238)
5'- GC CTG GAA AGC TGA GAT GGA GGG -3' (フラグメント229) (配列番号239) 5'- GC CTG GAA AGC TGA GAT GGA GG -3' (フラグメント230) (配列番号240) 5'- GC CTG GAA AGC TGA GAT GGA G -3' (フラグメント231) (配列番号241) 5'- GC CTG GAA AGC TGA GAT GGA -3' (フラグメント232) (配列番号242) 5'- GC CTG GAA AGC TGA GAT GG -3' (フラグメント233) (配列番号243) 5'- GC CTG GAA AGC TGA GAT G -3' (フラグメント234) (配列番号244) 5'- GC CTG GAA AGC TGA GAT -3' (フラグメント235) (配列番号245) 5'- GC CTG GAA AGC TGA GA-3' (フラグメント236) (配列番号246) 5'- GC CTG GAA AGC TGA G-3' (フラグメント237) (配列番号247) 5'- GC CTG GAA AGC TGA-3' (フラグメント238) (配列番号248) 5'- GC CTG GAA AGC TG-3' (フラグメント239) (配列番号249) 5'- GC CTG GAA AGC T-3' (フラグメント240) (配列番号250) 5'- GC CTG GAA AGC-3' (フラグメント241) (配列番号251) 5'- GC CTG GAA AG-3' (フラグメント242) (配列番号252) 5'- C CTG GAA AGC TGA GAT GG A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (
フラグメント243) (配列番号253) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フ
ラグメント244) (配列番号254) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラ
グメント245) (配列番号255) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラ
グメント246) (配列番号256) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグ
メント247) (配列番号257) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメ
ント248) (配列番号258) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメ
ント249) (配列番号259) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメン
ト250) (配列番号260) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント
251) (配列番号261) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント25
2) (配列番号262) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント253
) (配列番号263) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント254)
(配列番号264) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント255)
(配列番号265) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント256) (
配列番号266) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント257) (配
列番号267) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント258) (配
列番号268) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント259) (配列
番号269) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント260) (配列
番号270) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント261) (配列番
号271) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント262) (配列番号2
72) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント263) (配列番号27
3) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント264) (配列番号274
) 5'- C CTG GAA AGC TGA GAT GGA GGG CG -3' (フラグメント265) (配列番号275)
5'- C CTG GAA AGC TGA GAT GGA GGG C -3' (フラグメント266) (配列番号276)
5'- C CTG GAA AGC TGA GAT GGA GGG -3' (フラグメント267) (配列番号277) 5'- C CTG GAA AGC TGA GAT GGA GG -3' (フラグメント268) (配列番号278) 5'- C CTG GAA AGC TGA GAT GGA G -3' (フラグメント269) (配列番号279) 5'- C CTG GAA AGC TGA GAT GGA -3' (フラグメント270) (配列番号280) 5'- C CTG GAA AGC TGA GAT GG -3' (フラグメント271) (配列番号281) 5'- C CTG GAA AGC TGA GAT G -3' (フラグメント272) (配列番号282) 5'- C CTG GAA AGC TGA GAT -3' (フラグメント273) (配列番号283) 5'- C CTG GAA AGC TGA GA-3' (フラグメント274) (配列番号284) 5'- C CTG GAA AGC TGA G-3' (フラグメント275) (配列番号285) 5'- C CTG GAA AGC TGA-3' (フラグメント276) (配列番号286) 5'- C CTG GAA AGC TG-3' (フラグメント277) (配列番号287) 5'- C CTG GAA AGC T-3' (フラグメント278) (配列番号288) 5'- C CTG GAA AGC-3' (フラグメント279) (配列番号289) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラ
グメント280) (配列番号290) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラ
グメント281) (配列番号291) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグ
メント282) (配列番号292) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグ
メント283) (配列番号293) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメ
ント284) (配列番号294) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメン
ト285) (配列番号295) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメン
ト286) (配列番号296) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント2
87) (配列番号297) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント28
8) (配列番号298) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント289)
(配列番号299) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント290)
(配列番号300) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント291) (
配列番号301) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント292) (
配列番号302) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント293) (配
列番号303) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント294) (配列
番号304) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント295) (配列
番号305) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント296) (配列番
号306) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント297) (配列番
号307) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント298) (配列番号3
08) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント299) (配列番号309
) 5'- CTG GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント300) (配列番号310)
5'- CTG GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント301) (配列番号311)
5'- CTG GAA AGC TGA GAT GGA GGG CG -3' (フラグメント302) (配列番号312) 5'- CTG GAA AGC TGA GAT GGA GGG C -3' (フラグメント303) (配列番号313) 5'- CTG GAA AGC TGA GAT GGA GGG -3' (フラグメント304) (配列番号314) 5'- CTG GAA AGC TGA GAT GGA GG -3' (フラグメント305) (配列番号315) 5'- CTG GAA AGC TGA GAT GGA G -3' (フラグメント306) (配列番号316) 5'- CTG GAA AGC TGA GAT GGA -3' (フラグメント307) (配列番号317) 5'- CTG GAA AGC TGA GAT GG -3' (フラグメント308) (配列番号318) 5'- CTG GAA AGC TGA GAT G -3' (フラグメント309) (配列番号319) 5'- CTG GAA AGC TGA GAT -3' (フラグメント310) (配列番号320) 5'- CTG GAA AGC TGA GA-3' (フラグメント311) (配列番号321) 5'- CTG GAA AGC TGA G-3' (フラグメント312) (配列番号322) 5'- CTG GAA AGC TGA-3' (フラグメント313) (配列番号323) 5'- CTG GAA AGC TG-3' (フラグメント314) (配列番号324) 5'- CTG GAA AGC T-3' (フラグメント315) (配列番号325) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラ
グメント316) (配列番号326) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグ
メント317) (配列番号327) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグ
メント318) (配列番号328) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメ
ント319) (配列番号329) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメン
ト320) (配列番号330) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメン
ト321) (配列番号331) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント
322) (配列番号332) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント32
3) (配列番号333) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント324
) (配列番号334) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント325)
(配列番号335) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント326) (
配列番号336) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント327) (
配列番号337) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント328) (配
列番号338) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント329) (配列
番号339) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント330) (配列
番号340) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント331) (配列番
号341) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント332) (配列番
号342) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント333) (配列番号
343) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント334) (配列番号34
4) 5'- TG GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント335) (配列番号345)
5'- TG GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント336) (配列番号346)
5'- TG GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント337) (配列番号347) 5'- TG GAA AGC TGA GAT GGA GGG CG -3' (フラグメント338) (配列番号348) 5'- TG GAA AGC TGA GAT GGA GGG C -3' (フラグメント339) (配列番号349) 5'- TG GAA AGC TGA GAT GGA GGG -3' (フラグメント340) (配列番号350) 5'- TG GAA AGC TGA GAT GGA GG -3' (フラグメント341) (配列番号351) 5'- TG GAA AGC TGA GAT GGA G -3' (フラグメント342) (配列番号352) 5'- TG GAA AGC TGA GAT GGA -3' (フラグメント343) (配列番号353) 5'- TG GAA AGC TGA GAT GG -3' (フラグメント344) (配列番号354) 5'- TG GAA AGC TGA GAT G -3' (フラグメント345) (配列番号355) 5'- TG GAA AGC TGA GAT -3' (フラグメント346) (配列番号356) 5'- TG GAA AGC TGA GA-3' (フラグメント347) (配列番号357) 5'- TG GAA AGC TGA G-3' (フラグメント348) (配列番号358) 5'- TG GAA AGC TGA-3' (フラグメント349) (配列番号359) 5'- TG GAA AGC TG-3' (フラグメント350) (配列番号360) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグ
メント351) (配列番号361) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグ
メント352) (配列番号362) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメ
ント353) (配列番号363) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメ
ント354) (配列番号364) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメン
ト355) (配列番号365) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント
356) (配列番号366) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント3
57) (配列番号367) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント358
) (配列番号368) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント359)
(配列番号369) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント360) (
配列番号370) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント361) (
配列番号371) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント362) (配
列番号372) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント363) (配
列番号373) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント364) (配列
番号374) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント365) (配列番
号375) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント366) (配列番
号376) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント367) (配列番号
377) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント368) (配列番号3
78) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント369) (配列番号379
) 5'- G GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント370) (配列番号380)
5'- G GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント371) (配列番号381) 5'- G GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント372) (配列番号382) 5'- G GAA AGC TGA GAT GGA GGG CG -3' (フラグメント373) (配列番号383) 5'- G GAA AGC TGA GAT GGA GGG C -3' (フラグメント374) (配列番号384) 5'- G GAA AGC TGA GAT GGA GGG -3' (フラグメント375) (配列番号385) 5'- G GAA AGC TGA GAT GGA GG -3' (フラグメント376) (配列番号386) 5'- G GAA AGC TGA GAT GGA G -3' (フラグメント377) (配列番号387) 5'- G GAA AGC TGA GAT GGA -3' (フラグメント378) (配列番号388) 5'- G GAA AGC TGA GAT GG -3' (フラグメント379) (配列番号389) 5'- G GAA AGC TGA GAT G -3' (フラグメント380) (配列番号390) 5'- G GAA AGC TGA GAT -3' (フラグメント381) (配列番号391) 5'- G GAA AGC TGA GA-3' (フラグメント382) (配列番号392) 5'- G GAA AGC TGA G-3' (フラグメント383) (配列番号393) 5'- G GAA AGC TGA-3' (フラグメント384) (配列番号394) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメ
ント385) (配列番号395) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメ
ント386) (配列番号396) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメン
ト387) (配列番号397) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメン
ト388) (配列番号398) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント3
89) (配列番号399) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント39
0) (配列番号400) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント391
) (配列番号401) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント392)
(配列番号402) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント393) (
配列番号403) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント394) (配
列番号404) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント395) (配
列番号405) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント396) (配列
番号406) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント397) (配列
番号407) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント398) (配列番
号408) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント399) (配列番号
409) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント400) (配列番号4
10) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント401) (配列番号41
1) 5'- GAA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント402) (配列番号412
) 5'- GAA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント403) (配列番号413)
5'- GAA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント404) (配列番号414) 5'- GAA AGC TGA GAT GGA GGG CGG C-3' (フラグメント405) (配列番号415) 5'- GAA AGC TGA GAT GGA GGG CGG -3' (フラグメント406) (配列番号416) 5'- GAA AGC TGA GAT GGA GGG CG -3' (フラグメント407) (配列番号417) 5'- GAA AGC TGA GAT GGA GGG C -3' (フラグメント408) (配列番号418) 5'- GAA AGC TGA GAT GGA GGG -3' (フラグメント409) (配列番号419) 5'- GAA AGC TGA GAT GGA GG -3' (フラグメント410) (配列番号420) 5'- GAA AGC TGA GAT GGA G -3' (フラグメント411) (配列番号421) 5'- GAA AGC TGA GAT GGA -3' (フラグメント412) (配列番号422) 5'- GAA AGC TGA GAT GG -3' (フラグメント413) (配列番号423) 5'- GAA AGC TGA GAT G -3' (フラグメント414) (配列番号424) 5'- GAA AGC TGA GAT -3' (フラグメント415) (配列番号425) 5'- GAA AGC TGA GA-3' (フラグメント416) (配列番号426) 5'- GAA AGC TGA G-3' (フラグメント417) (配列番号427) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメ
ント418) (配列番号428) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメン
ト419) (配列番号429) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメン
ト420) (配列番号430) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント
421) (配列番号431) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント42
2) (配列番号432) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント423
) (配列番号433) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3'(フラグメント424)
(配列番号434) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント425) (
配列番号435) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント426) (
配列番号436) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント427) (配
列番号437) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント428) (配列
番号438) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント429) (配列
番号439) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント430) (配列番
号440) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント431) (配列番号
441) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント432) (配列番号4
42) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント433) (配列番号44
3) 5'- AA AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント434) (配列番号444
) 5'- AA AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント435) (配列番号445)
5'- AA AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント436) (配列番号446) 5'- AA AGC TGA GAT GGA GGG CGG CA-3' (フラグメント437) (配列番号447) 5'- AA AGC TGA GAT GGA GGG CGG C-3' (フラグメント438) (配列番号448) 5'- AA AGC TGA GAT GGA GGG CGG -3' (フラグメント439) (配列番号449) 5'- AA AGC TGA GAT GGA GGG CG -3' (フラグメント440) (配列番号450) 5'- AA AGC TGA GAT GGA GGG C -3' (フラグメント441) (配列番号451) 5'- AA AGC TGA GAT GGA GGG -3' (フラグメント442) (配列番号452) 5'- AA AGC TGA GAT GGA GG -3' (フラグメント443) (配列番号453) 5'- AA AGC TGA GAT GGA G -3' (フラグメント444) (配列番号454) 5'- AA AGC TGA GAT GGA -3' (フラグメント445) (配列番号455) 5'- AA AGC TGA GAT GG -3' (フラグメント446) (配列番号456) 5'- AA AGC TGA GAT G -3' (フラグメント447) (配列番号457) 5'- AA AGC TGA GAT -3' (フラグメント448) (配列番号458) 5'- AA AGC TGA GA-3' (フラグメント449) (配列番号459) 5'- A AGC TGA GAT GGA GGG CG G CAT GGC GGG CAC AGG CTG GGC-3' (フラグメ
ント450) (配列番号460) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメン
ト451) (配列番号461) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント
452) (配列番号462) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント4
53) (配列番号463) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント454
) (配列番号464) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント455) (配列番号465) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント456)
(配列番号466) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント457) (
配列番号467) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント458) (配
列番号468) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント459) (配列
番号469) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント460) (配列
番号470) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント461) (配列番
号471) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント462) (配列番
号472) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント463) (配列番号4
73) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント464) (配列番号47
4) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント465) (配列番号475
) 5'- A AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント466) (配列番号476)
5'- A AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント467) (配列番号477)
5'- A AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント468) (配列番号478) 5'- A AGC TGA GAT GGA GGG CGG CA-3' (フラグメント469) (配列番号479) 5'- A AGC TGA GAT GGA GGG CGG C-3' (フラグメント470) (配列番号480) 5'- A AGC TGA GAT GGA GGG CGG -3' (フラグメント471) (配列番号481) 5'- A AGC TGA GAT GGA GGG CG -3' (フラグメント472) (配列番号482) 5'- A AGC TGA GAT GGA GGG C -3' (フラグメント473) (配列番号483) 5'- A AGC TGA GAT GGA GGG -3' (フラグメント474) (配列番号484) 5'- A AGC TGA GAT GGA GG -3' (フラグメント475) (配列番号485) 5'- A AGC TGA GAT GGA G -3' (フラグメント476) (配列番号486) 5'- A AGC TGA GAT GGA -3' (フラグメント477) (配列番号487) 5'- A AGC TGA GAT GG -3' (フラグメント478) (配列番号488) 5'- A AGC TGA GAT G -3' (フラグメント479) (配列番号489) 5'- A AGC TGA GAT -3' (フラグメント480) (配列番号490) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント
481) (配列番号491) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント4
82) (配列番号492) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント48
3) (配列番号493) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント484
) (配列番号494) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント485)
(配列番号495) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント486) (
配列番号496) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント487) (
配列番号497) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント488) (配
列番号498) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント489) (配列
番号499) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント490) (配列番
号500) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント491) (配列番
号501) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント492) (配列番号
502) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント493) (配列番号5
03) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント494) (配列番号504
) 5'- AGC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント495) (配列番号505)
5'- AGC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント496) (配列番号506)
5'- AGC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント497) (配列番号507) 5'- AGC TGA GAT GGA GGG CGG CAT G -3' (フラグメント498) (配列番号508) 5'- AGC TGA GAT GGA GGG CGG CAT -3' (フラグメント499) (配列番号509) 5'- AGC TGA GAT GGA GGG CGG CA-3' (フラグメント500) (配列番号510) 5'- AGC TGA GAT GGA GGG CGG C-3' (フラグメント501) (配列番号511) 5'- AGC TGA GAT GGA GGG CGG -3' (フラグメント502) (配列番号512) 5'- AGC TGA GAT GGA GGG CG -3' (フラグメント503) (配列番号513) 5'- AGC TGA GAT GGA GGG C -3' (フラグメント504) (配列番号514) 5'- AGC TGA GAT GGA GGG -3' (フラグメント505) (配列番号515) 5'- AGC TGA GAT GGA GG -3' (フラグメント506) (配列番号516) 5'- AGC TGA GAT GGA G -3' (フラグメント507) (配列番号517) 5'- AGC TGA GAT GGA -3' (フラグメント508) (配列番号518) 5'- AGC TGA GAT GG -3' (フラグメント509) (配列番号519) 5'- AGC TGA GAT G -3' (フラグメント510) (配列番号520) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント5
11) (配列番号521) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント51
2) (配列番号522) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント513
) (配列番号523) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント514)
(配列番号524) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント515) (
配列番号525) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント516) (
配列番号526) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント517) (配
列番号527) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント518) (配列
番号528) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント519) (配列
番号529) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント520) (配列番
号530) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント521) (配列番号
531) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント522) (配列番号5
32) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント523) (配列番号53
3) 5'- GC TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント524) (配列番号534)
5'- GC TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント525) (配列番号535)
5'- GC TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント526) (配列番号536) 5'- GC TGA GAT GGA GGG CGG CAT GG -3' (フラグメント527) (配列番号537) 5'- GC TGA GAT GGA GGG CGG CAT G -3' (フラグメント528) (配列番号538) 5'- GC TGA GAT GGA GGG CGG CAT -3' (フラグメント529) (配列番号539) 5'- GC TGA GAT GGA GGG CGG CA-3' (フラグメント530) (配列番号540) 5'- GC TGA GAT GGA GGG CGG C-3' (フラグメント531) (配列番号541) 5'- GC TGA GAT GGA GGG CGG -3' (フラグメント532) (配列番号542) 5'- GC TGA GAT GGA GGG CG -3' (フラグメント533) (配列番号543) 5'- GC TGA GAT GGA GGG C -3' (フラグメント534) (配列番号544) 5'- GC TGA GAT GGA GGG -3' (フラグメント535) (配列番号545) 5'- GC TGA GAT GGA GG -3' (フラグメント536) (配列番号546) 5'- GC TGA GAT GGA G -3' (フラグメント537) (配列番号547) 5'- GC TGA GAT GGA -3' (フラグメント538) (配列番号548) 5'- GC TGA GAT GG -3' (フラグメント539) (配列番号549) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント54
0) (配列番号550) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント541
) (配列番号551) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント542)
(配列番号552) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント543)
(配列番号553) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント544) (
配列番号554) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント545) (配
列番号555) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント546) (配
列番号556) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント547) (配列
番号557) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント548) (配列番
号558) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント549) (配列番号
559) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント550) (配列番号5
60) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント551) (配列番号56
1) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント552) (配列番号562
) 5'- C TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント553) (配列番号563)
5'- C TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント554) (配列番号564) 5'- C TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント555) (配列番号565) 5'- C TGA GAT GGA GGG CGG CAT GG -3' (フラグメント556) (配列番号566) 5'- C TGA GAT GGA GGG CGG CAT G -3' (フラグメント557) (配列番号567) 5'- C TGA GAT GGA GGG CGG CAT -3' (フラグメント558) (配列番号568) 5'- C TGA GAT GGA GGG CGG CA-3' (フラグメント559) (配列番号569) 5'- C TGA GAT GGA GGG CGG C-3' (フラグメント560) (配列番号570) 5'- C TGA GAT GGA GGG CGG -3' (フラグメント561) (配列番号571) 5'- C TGA GAT GGA GGG CG -3' (フラグメント562) (配列番号572) 5'- C TGA GAT GGA GGG C -3' (フラグメント563) (配列番号573) 5'- C TGA GAT GGA GGG -3' (フラグメント564) (配列番号574) 5'- C TGA GAT GGA GG -3' (フラグメント565) (配列番号575) 5'- C TGA GAT GGA G -3' (フラグメント566) (配列番号576) 5'- C TGA GAT GGA -3' (フラグメント567) (配列番号577) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント568)
(配列番号578) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント569)
(配列番号579) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント570) (
配列番号580) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント571) (
配列番号581) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント572) (配
列番号582) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント573) (配列
番号583) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント574) (配列
番号584) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント575) (配列番
号585) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント576) (配列番号
586) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント577) (配列番号58
7) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント578) (配列番号588
) 5'- TGA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント579) (配列番号589)
5'- TGA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント580) (配列番号590)
5'- TGA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント581) (配列番号591) 5'- TGA GAT GGA GGG CGG CAT GGC G-3' (フラグメント582) (配列番号592) 5'- TGA GAT GGA GGG CGG CAT GGC -3' (フラグメント583) (配列番号593) 5'- TGA GAT GGA GGG CGG CAT GG -3' (フラグメント584) (配列番号594) 5'- TGA GAT GGA GGG CGG CAT G -3' (フラグメント585) (配列番号595) 5'- TGA GAT GGA GGG CGG CAT -3' (フラグメント586) (配列番号596) 5'- TGA GAT GGA GGG CGG CA-3' (フラグメント587) (配列番号597) 5'- TGA GAT GGA GGG CGG C-3' (フラグメント588) (配列番号598) 5'- TGA GAT GGA GGG CGG -3' (フラグメント589) (配列番号599) 5'- TGA GAT GGA GGG CG -3' (フラグメント590) (配列番号600) 5'- TGA GAT GGA GGG C -3' (フラグメント591) (配列番号601) 5'- TGA GAT GGA GGG -3' (フラグメント592) (配列番号602) 5'- TGA GAT GGA GG -3' (フラグメント593) (配列番号603) 5'- TGA GAT GGA G -3' (フラグメント594) (配列番号604) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント595)
(配列番号605) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント596) (
配列番号606) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント597) (
配列番号607) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント598) (配
列番号608) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント599) (配列
番号609) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント600) (配列
番号610) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント601) (配列番
号611) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント602) (配列番号
612) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント603) (配列番号6
13) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント604) (配列番号614
) 5'- GA GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント605) (配列番号615)
5'- GA GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント606) (配列番号616)
5'- GA GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント607) (配列番号617) 5'- GA GAT GGA GGG CGG CAT GGC GG-3' (フラグメント608) (配列番号618) 5'- GA GAT GGA GGG CGG CAT GGC G-3' (フラグメント609) (配列番号619) 5'- GA GAT GGA GGG CGG CAT GGC -3' (フラグメント610) (配列番号620) 5'- GA GAT GGA GGG CGG CAT GG -3' (フラグメント611) (配列番号621) 5'- GA GAT GGA GGG CGG CAT G -3' (フラグメント612) (配列番号622) 5'- GA GAT GGA GGG CGG CAT -3' (フラグメント613) (配列番号623) 5'- GA GAT GGA GGG CGG CA-3' (フラグメント614) (配列番号624) 5'- GA GAT GGA GGG CGG C-3' (フラグメント615) (配列番号625) 5'- GA GAT GGA GGG CGG -3' (フラグメント616) (配列番号626) 5'- GA GAT GGA GGG CG -3' (フラグメント617) (配列番号627) 5'- GA GAT GGA GGG C -3' (フラグメント618) (配列番号628) 5'- GA GAT GGA GGG -3' (フラグメント619) (配列番号629) 5'- GA GAT GGA GG -3' (フラグメント620) (配列番号630) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント621) (
配列番号631) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント622) (
配列番号632) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント623) (配
列番号633) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント624) (配
列番号634) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント625) (配列
番号635) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント626) (配列番
号636) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント627) (配列番
号637) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント628) (配列番号6
38) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント629) (配列番号63
9) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント630) (配列番号640)
5'- A GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント631) (配列番号641)
5'- A GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント632) (配列番号642) 5'- A GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント633) (配列番号643) 5'- A GAT GGA GGG CGG CAT GGC GG-3' (フラグメント634) (配列番号644) 5'- A GAT GGA GGG CGG CAT GGC G-3' (フラグメント635) (配列番号645) 5'- A GAT GGA GGG CGG CAT GGC -3' (フラグメント636) (配列番号646) 5'- A GAT GGA GGG CGG CAT GG -3' (フラグメント637) (配列番号647) 5'- A GAT GGA GGG CGG CAT G -3' (フラグメント638) (配列番号648) 5'- A GAT GGA GGG CGG CAT -3' (フラグメント639) (配列番号649) 5'- A GAT GGA GGG CGG CA-3' (フラグメント640) (配列番号650) 5'- A GAT GGA GGG CGG C-3' (フラグメント641) (配列番号651) 5'- A GAT GGA GGG CGG -3' (フラグメント642) (配列番号652) 5'- A GAT GGA GGG CG -3' (フラグメント643) (配列番号653) 5'- A GAT GGA GGG C -3' (フラグメント644) (配列番号654) 5'- A GAT GGA GGG -3' (フラグメント645) (配列番号655) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント646) (配
列番号656) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント647) (配
列番号657) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント648) (配列
番号658) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント6) (配列番
号659) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント650) (配列番
号660) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント651) (配列番号
661) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント652) (配列番号6
62) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント653) (配列番号663
) 5'- GAT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント654) (配列番号664)
5'- GAT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント655) (配列番号665) 5'- GAT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント656) (配列番号666) 5'- GAT GGA GGG CGG CAT GGC GGG C-3' (フラグメント657) (配列番号667) 5'- GAT GGA GGG CGG CAT GGC GGG -3' (フラグメント658) (配列番号668) 5'- GAT GGA GGG CGG CAT GGC GG-3' (フラグメント659) (配列番号669) 5'- GAT GGA GGG CGG CAT GGC G-3' (フラグメント660) (配列番号670) 5'- GAT GGA GGG CGG CAT GGC -3' (フラグメント661) (配列番号671) 5'- GAT GGA GGG CGG CAT GG -3' (フラグメント662) (配列番号672) 5'- GAT GGA GGG CGG CAT G -3' (フラグメント663) (配列番号673) 5'- GAT GGA GGG CGG CAT -3' (フラグメント664) (配列番号674) 5'- GAT GGA GGG CGG CA-3' (フラグメント665) (配列番号675) 5'- GAT GGA GGG CGG C-3' (フラグメント666) (配列番号676) 5'- GAT GGA GGG CGG -3' (フラグメント667) (配列番号677) 5'- GAT GGA GGG CG -3' (フラグメント668) (配列番号678) 5'- GAT GGA GGG C -3' (フラグメント669) (配列番号679) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント670) (配
列番号680) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント671) (配列
番号681) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント672) (配列
番号682) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント673) (配列番
号683) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント674) (配列番号
684) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント675) (配列番号6
85) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント676) (配列番号68
6) 5'- AT GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント677) (配列番号687)
5'- AT GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント678) (配列番号688)
5'- AT GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント679) (配列番号689) 5'- AT GGA GGG CGG CAT GGC GGG CA-3' (フラグメント680) (配列番号690) 5'- AT GGA GGG CGG CAT GGC GGG C-3' (フラグメント681) (配列番号691) 5'- AT GGA GGG CGG CAT GGC GGG -3' (フラグメント682) (配列番号692) 5'- AT GGA GGG CGG CAT GGC GG-3' (フラグメント683) (配列番号693) 5'- AT GGA GGG CGG CAT GGC G-3' (フラグメント684) (配列番号694) 5'- AT GGA GGG CGG CAT GGC -3' (フラグメント685) (配列番号695) 5'- AT GGA GGG CGG CAT GG -3' (フラグメント686) (配列番号696) 5'- AT GGA GGG CGG CAT G -3' (フラグメント687) (配列番号697) 5'- AT GGA GGG CGG CAT -3' (フラグメント688) (配列番号698) 5'- AT GGA GGG CGG CA-3' (フラグメント689) (配列番号699) 5'- AT GGA GGG CGG C-3' (フラグメント690) (配列番号700) 5'- AT GGA GGG CGG -3' (フラグメント691) (配列番号701) 5'- AT GGA GGG CG -3' (フラグメント692) (配列番号702) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント693) (配列
番号703) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント694) (配列
番号704) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント695) (配列番
号705) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント696) (配列番
号706) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント697) (配列番号7
07) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント698) (配列番号70
8) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント699) (配列番号709
) 5'- T GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント700) (配列番号710)
5'- T GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント701) (配列番号711) 5'- T GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント702) (配列番号712) 5'- T GGA GGG CGG CAT GGC GGG CA-3' (フラグメント703) (配列番号713) 5'- T GGA GGG CGG CAT GGC GGG C-3' (フラグメント704) (配列番号714) 5'- T GGA GGG CGG CAT GGC GGG -3' (フラグメント705) (配列番号715) 5'- T GGA GGG CGG CAT GGC GG-3' (フラグメント706) (配列番号716) 5'- T GGA GGG CGG CAT GGC G-3' (フラグメント707) (配列番号717) 5'- T GGA GGG CGG CAT GGC -3' (フラグメント708) (配列番号718) 5'- T GGA GGG CGG CAT GG -3' (フラグメント709) (配列番号719) 5'- T GGA GGG CGG CAT G -3' (フラグメント710) (配列番号720) 5'- T GGA GGG CGG CAT -3' (フラグメント711) (配列番号721) 5'- T GGA GGG CGG CA-3' (フラグメント712) (配列番号722) 5'- T GGA GGG CGG C-3' (フラグメント713) (配列番号723) 5'- T GGA GGG CGG -3' (フラグメント714) (配列番号724) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント715) (配列番
号725) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント716) (配列番
号726) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント717) (配列番号
727) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント718) (配列番号7
28) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント719) (配列番号729
) 5'- GGA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント720) (配列番号730)
5'- GGA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント721) (配列番号731)
5'- GGA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント722) (配列番号732) 5'- GGA GGG CGG CAT GGC GGG CAC A-3' (フラグメント723) (配列番号733) 5'- GGA GGG CGG CAT GGC GGG CAC-3' (フラグメント724) (配列番号734) 5'- GGA GGG CGG CAT GGC GGG CA-3' (フラグメント725) (配列番号735) 5'- GGA GGG CGG CAT GGC GGG C-3' (フラグメント726) (配列番号736) 5'- GGA GGG CGG CAT GGC GGG -3' (フラグメント727) (配列番号737) 5'- GGA GGG CGG CAT GGC GG-3' (フラグメント728) (配列番号738) 5'- GGA GGG CGG CAT GGC G-3' (フラグメント729) (配列番号739) 5'- GGA GGG CGG CAT GGC -3' (フラグメント730) (配列番号740) 5'- GGA GGG CGG CAT GG -3' (フラグメント731) (配列番号741) 5'- GGA GGG CGG CAT G -3' (フラグメント732) (配列番号742) 5'- GGA GGG CGG CAT -3' (フラグメント733) (配列番号743) 5'- GGA GGG CGG CA-3' (フラグメント734) (配列番号744) 5'- GGA GGG CGG C-3' (フラグメント735) (配列番号745) 5'- GA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント736) (配列番
号746) 5'- GA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント737) (配列番号
747) 5'- GA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント738) (配列番号7
48) 5'- GA GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント739) (配列番号74
9) 5'- GA GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント740) (配列番号750)
5'- GA GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント741) (配列番号751)
5'- GA GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント742) (配列番号752) 5'- GA GGG CGG CAT GGC GGG CAC AG-3' (フラグメント743) (配列番号753) 5'- GA GGG CGG CAT GGC GGG CAC A-3' (フラグメント744) (配列番号754) 5'- GA GGG CGG CAT GGC GGG CAC-3' (フラグメント745) (配列番号755) 5'- GA GGG CGG CAT GGC GGG CA-3' (フラグメント746) (配列番号756) 5'- GA GGG CGG CAT GGC GGG C-3' (フラグメント747) (配列番号757) 5'- GA GGG CGG CAT GGC GGG -3' (フラグメント748) (配列番号758) 5'- GA GGG CGG CAT GGC GG-3' (フラグメント749) (配列番号759) 5'- GA GGG CGG CAT GGC G-3' (フラグメント750) (配列番号760) 5'- GA GGG CGG CAT GGC -3' (フラグメント751) (配列番号761) 5'- GA GGG CGG CAT GG -3' (フラグメント752) (配列番号762) 5'- GA GGG CGG CAT G -3' (フラグメント753) (配列番号763) 5'- GA GGG CGG CAT -3' (フラグメント754) (配列番号764) 5'- GA GGG CGG CA-3' (フラグメント755) (配列番号765) 5'- A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント756) (配列番号
766) 5'- A GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント757) (配列番号7
67) 5'- A GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント758) (配列番号76
8) 5'- A GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント759) (配列番号769
) 5'- A GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント760) (配列番号770)
5'- A GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント761) (配列番号771) 5'- A GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント762) (配列番号772) 5'- A GGG CGG CAT GGC GGG CAC AG-3' (フラグメント763) (配列番号773) 5'- A GGG CGG CAT GGC GGG CAC A-3' (フラグメント764) (配列番号774) 5'- A GGG CGG CAT GGC GGG CAC-3' (フラグメント765) (配列番号775) 5'- A GGG CGG CAT GGC GGG CA-3' (フラグメント766) (配列番号776) 5'- A GGG CGG CAT GGC GGG C-3' (フラグメント767) (配列番号777) 5'- A GGG CGG CAT GGC GGG -3' (フラグメント768) (配列番号778) 5'- A GGG CGG CAT GGC GG-3' (フラグメント769) (配列番号779) 5'- A GGG CGG CAT GGC G-3' (フラグメント770) (配列番号780) 5'- A GGG CGG CAT GGC -3' (フラグメント771) (配列番号781) 5'- A GGG CGG CAT GG -3' (フラグメント772) (配列番号782) 5'- A GGG CGG CAT G -3' (フラグメント773) (配列番号783) 5'- A GGG CGG CAT -3' (フラグメント774) (配列番号784) 5'- GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント775) (配列番号78
5) 5'- GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント776) (配列番号786
) 5'- GGG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント777) (配列番号787)
5'- GGG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント778) (配列番号788)
5'- GGG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント779) (配列番号789) 5'- GGG CGG CAT GGC GGG CAC AGG C-3' (フラグメント780) (配列番号790) 5'- GGG CGG CAT GGC GGG CAC AGG -3' (フラグメント781) (配列番号791) 5'- GGG CGG CAT GGC GGG CAC AG-3' (フラグメント782) (配列番号792) 5'- GGG CGG CAT GGC GGG CAC A-3' (フラグメント783) (配列番号793) 5'- GGG CGG CAT GGC GGG CAC-3' (フラグメント784) (配列番号794) 5'- GGG CGG CAT GGC GGG CA-3' (フラグメント785) (配列番号795) 5'- GGG CGG CAT GGC GGG C-3' (フラグメント786) (配列番号796) 5'- GGG CGG CAT GGC GGG -3' (フラグメント787) (配列番号797) 5'- GGG CGG CAT GGC GG-3' (フラグメント788) (配列番号798) 5'- GGG CGG CAT GGC G-3' (フラグメント789) (配列番号799) 5'- GGG CGG CAT GGC -3' (フラグメント790) (配列番号800) 5'- GGG CGG CAT GG -3' (フラグメント791) (配列番号801) 5'- GGG CGG CAT G -3' (フラグメント792) (配列番号802) 5'- GG CGG CAT GGC GGG CAC AG G CTG GGC-3' (フラグメント793) (配列番号80
3) 5'- GG CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント794) (配列番号804)
5'- GG CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント795) (配列番号805)
5'- GG CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント796) (配列番号806) 5'- GG CGG CAT GGC GGG CAC AGG CT-3' (フラグメント797) (配列番号807) 5'- GG CGG CAT GGC GGG CAC AGG C-3' (フラグメント798) (配列番号808) 5'- GG CGG CAT GGC GGG CAC AGG -3' (フラグメント799) (配列番号809) 5'- GG CGG CAT GGC GGG CAC AG-3' (フラグメント800) (配列番号810) 5'- GG CGG CAT GGC GGG CAC A-3' (フラグメント801) (配列番号811) 5'- GG CGG CAT GGC GGG CAC-3' (フラグメント802) (配列番号812) 5'- GG CGG CAT GGC GGG CA-3' (フラグメント803) (配列番号813) 5'- GG CGG CAT GGC GGG C-3' (フラグメント804) (配列番号814) 5'- GG CGG CAT GGC GGG -3' (フラグメント805) (配列番号815) 5'- GG CGG CAT GGC GG-3' (フラグメント806) (配列番号816) 5'- GG CGG CAT GGC G-3' (フラグメント807) (配列番号817) 5'- GG CGG CAT GGC -3' (フラグメント808) (配列番号818) 5'- GG CGG CAT GG -3' (フラグメント809) (配列番号819) 5'- G CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント810) (配列番号820)
5'- G CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント811) (配列番号821)
5'- G CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント812) (配列番号822) 5'- G CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント813) (配列番号823) 5'- G CGG CAT GGC GGG CAC AGG CT-3' (フラグメント814) (配列番号824) 5'- G CGG CAT GGC GGG CAC AGG C-3' (フラグメント815) (配列番号825) 5'- G CGG CAT GGC GGG CAC AGG -3' (フラグメント816) (配列番号826) 5'- G CGG CAT GGC GGG CAC AG-3' (フラグメント817) (配列番号827) 5'- G CGG CAT GGC GGG CAC A-3' (フラグメント818) (配列番号828) 5'- G CGG CAT GGC GGG CAC-3' (フラグメント819) (配列番号829) 5'- G CGG CAT GGC GGG CA-3' (フラグメント820) (配列番号830) 5'- G CGG CAT GGC GGG C-3' (フラグメント821) (配列番号831) 5'- G CGG CAT GGC GGG -3' (フラグメント822) (配列番号832) 5'- G CGG CAT GGC GG-3' (フラグメント823) (配列番号833) 5'- G CGG CAT GGC G-3' (フラグメント824) (配列番号834) 5'- G CGG CAT GGC -3' (フラグメント825) (配列番号835) 5'- CGG CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント826) (配列番号836) 5'- CGG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント827) (配列番号837) 5'- CGG CAT GGC GGG CAC AGG CTG G-3' (フラグメント828) (配列番号838) 5'- CGG CAT GGC GGG CAC AGG CTG -3' (フラグメント829) (配列番号839) 5'- CGG CAT GGC GGG CAC AGG CT-3' (フラグメント830) (配列番号840) 5'- CGG CAT GGC GGG CAC AGG C-3' (フラグメント831) (配列番号841) 5'- CGG CAT GGC GGG CAC AGG -3' (フラグメント832) (配列番号842) 5'- CGG CAT GGC GGG CAC AG-3' (フラグメント833) (配列番号843) 5'- CGG CAT GGC GGG CAC A-3' (フラグメント834) (配列番号844) 5'- CGG CAT GGC GGG CAC-3' (フラグメント835) (配列番号845) 5'- CGG CAT GGC GGG CA-3' (フラグメント836) (配列番号846) 5'- CGG CAT GGC GGG C-3' (フラグメント837) (配列番号847) 5'- CGG CAT GGC GGG -3' (フラグメント838) (配列番号848) 5'- CGG CAT GGC GG-3' (フラグメント839) (配列番号849) 5'- CGG CAT GGC G-3' (フラグメント840) (配列番号850) 5'- GG CAT GGC GGG CAC AGG C TG GGC-3' (フラグメント841) (配列番号851) 5'- GG CAT GGC GGG CAC AGG CTG GG-3' (フラグメント842) (配列番号852) 5'- GG CAT GGC GGG CAC AGG CTG G-3' (フラグメント843) (配列番号853) 5'- GG CAT GGC GGG CAC AGG CTG -3' (フラグメント844) (配列番号854) 5'- GG CAT GGC GGG CAC AGG CT-3' (フラグメント845) (配列番号855) 5'- GG CAT GGC GGG CAC AGG C-3' (フラグメント846) (配列番号856) 5'- GG CAT GGC GGG CAC AGG -3' (フラグメント847) (配列番号857) 5'- GG CAT GGC GGG CAC AG-3' (フラグメント848) (配列番号858) 5'- GG CAT GGC GGG CAC A-3' (フラグメント849) (配列番号859) 5'- GG CAT GGC GGG CAC-3' (フラグメント850) (配列番号860) 5'- GG CAT GGC GGG CA-3' (フラグメント851) (配列番号861) 5'- GG CAT GGC GGG C-3' (フラグメント852) (配列番号862) 5'- GG CAT GGC GGG -3' (フラグメント853) (配列番号863) 5'- GG CAT GGC GG-3' (フラグメント854) (配列番号864) 5'- G CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント855) (配列番号865) 5'- G CAT GGC GGG CAC AGG CTG GG-3' (フラグメント856) (配列番号866) 5'- G CAT GGC GGG CAC AGG CTG G-3' (フラグメント857) (配列番号867) 5'- G CAT GGC GGG CAC AGG CTG -3' (フラグメント858) (配列番号868) 5'- G CAT GGC GGG CAC AGG CT-3' (フラグメント859) (配列番号869) 5'- G CAT GGC GGG CAC AGG C-3' (フラグメント860) (配列番号870) 5'- G CAT GGC GGG CAC AGG -3' (フラグメント861) (配列番号871) 5'- G CAT GGC GGG CAC AG-3' (フラグメント862) (配列番号872) 5'- G CAT GGC GGG CAC A-3' (フラグメント863) (配列番号873) 5'- G CAT GGC GGG CAC-3' (フラグメント864) (配列番号874) 5'- G CAT GGC GGG CA-3' (フラグメント865) (配列番号875) 5'- G CAT GGC GGG C-3' (フラグメント866) (配列番号876) 5'- G CAT GGC GGG -3' (フラグメント867) (配列番号877) 5'- CAT GGC GGG CAC AGG CTG GGC-3' (フラグメント868) (配列番号878) 5'- CAT GGC GGG CAC AGG CTG GG-3' (フラグメント869) (配列番号879) 5'- CAT GGC GGG CAC AGG CTG G-3' (フラグメント870) (配列番号880) 5'- CAT GGC GGG CAC AGG CTG -3' (フラグメント871) (配列番号881) 5'- CAT GGC GGG CAC AGG CT-3' (フラグメント872) (配列番号882) 5'- CAT GGC GGG CAC AGG C-3' (フラグメント873) (配列番号883) 5'- CAT GGC GGG CAC AGG -3' (フラグメント874) (配列番号884) 5'- CAT GGC GGG CAC AG-3' (フラグメント875) (配列番号885) 5'- CAT GGC GGG CAC A-3' (フラグメント876) (配列番号886) 5'- CAT GGC GGG CAC-3' (フラグメント877) (配列番号887) 5'- CAT GGC GGG CA-3' (フラグメント878) (配列番号888) 5'- CAT GGC GGG C-3' (フラグメント879) (配列番号889) 5'- AT GGC GGG CAC AGG CTG GGC-3' (フラグメント880) (配列番号890) 5'- AT GGC GGG CAC AGG CTG GG-3' (フラグメント881) (配列番号891) 5'- AT GGC GGG CAC AGG CTG G-3' (フラグメント882) (配列番号892) 5'- AT GGC GGG CAC AGG CTG -3' (フラグメント883) (配列番号893) 5'- AT GGC GGG CAC AGG CT-3' (フラグメント884) (配列番号894) 5'- AT GGC GGG CAC AGG C-3' (フラグメント885) (配列番号895) 5'- AT GGC GGG CAC AGG -3' (フラグメント886) (配列番号896) 5'- AT GGC GGG CAC AG-3' (フラグメント887) (配列番号897) 5'- AT GGC GGG CAC A-3' (フラグメント888) (配列番号898) 5'- AT GGC GGG CAC-3' (フラグメント889) (配列番号899) 5'- AT GGC GGG CA-3' (フラグメント890) (配列番号900) 5'- T GGC GGG CAC AGG CTG GGC-3' (フラグメント891) (配列番号901) 5'- T GGC GGG CAC AGG CTG GG-3' (フラグメント892) (配列番号902) 5'- T GGC GGG CAC AGG CTG G-3' (フラグメント893) (配列番号903) 5'- T GGC GGG CAC AGG CTG -3' (フラグメント894) (配列番号904) 5'- T GGC GGG CAC AGG CT-3' (フラグメント895) (配列番号905) 5'- T GGC GGG CAC AGG C-3' (フラグメント896) (配列番号906) 5'- T GGC GGG CAC AGG -3' (フラグメント897) (配列番号907) 5'- T GGC GGG CAC AG-3' (フラグメント898) (配列番号908) 5'- T GGC GGG CAC A-3' (フラグメント899) (配列番号909) 5'- T GGC GGG CAC-3' (フラグメント900) (配列番号910) 5'- GGC GGG CAC AGG CTG GGC-3' (フラグメント901) (配列番号911) 5'- GGC GGG CAC AGG CTG GG-3' (フラグメント902) (配列番号912) 5'- GGC GGG CAC AGG CTG G-3' (フラグメント903) (配列番号913) 5'- GGC GGG CAC AGG CTG -3' (フラグメント904) (配列番号914) 5'- GGC GGG CAC AGG CT-3' (フラグメント905) (配列番号915) 5'- GGC GGG CAC AGG C-3' (フラグメント906) (配列番号916) 5'- GGC GGG CAC AGG -3' (フラグメント907) (配列番号917) 5'- GGC GGG CAC AG-3' (フラグメント908) (配列番号918) 5'- GGC GGG CAC A-3' (フラグメント909) (配列番号919) 5'- GC GGG CAC AGG CTG GGC-3' (フラグメント910) (配列番号920) 5'- GC GGG CAC AGG CTG GG-3' (フラグメント911) (配列番号921) 5'- GC GGG CAC AGG CTG G-3' (フラグメント912) (配列番号922) 5'- GC GGG CAC AGG CTG -3' (フラグメント913) (配列番号923) 5'- GC GGG CAC AGG CT-3' (フラグメント914) (配列番号924) 5'- GC GGG CAC AGG C-3' (フラグメント915) (配列番号925) 5'- GC GGG CAC AGG -3' (フラグメント916) (配列番号926) 5'- GC GGG CAC AG-3' (フラグメント917) (配列番号927) 5'- C GGG CAC AGG CTG GGC-3' (フラグメント918) (配列番号928) 5'- GGG CAC AGG CTG GG-3' (フラグメント919) (配列番号929) 5'- C GGG CAC AGG CTG G-3' (フラグメント920) (配列番号930) 5'- C GGG CAC AGG CTG -3' (フラグメント921) (配列番号931) 5'- C GGG CAC AGG CT-3' (フラグメント922) (配列番号932) 5'- C GGG CAC AGG C-3' (フラグメント923) (配列番号933) 5'- C GGG CAC AGG -3' (フラグメント924) (配列番号934) 5'- GGG CAC AGG CTG GGC-3' (フラグメント925) (配列番号935) 5'- GGG CAC AGG CTG GG-3' (フラグメント926) (配列番号936) 5'- GGG CAC AGG CTG G-3' (フラグメント927) (配列番号937) 5'- GGG CAC AGG CTG -3' (フラグメント928) (配列番号938) 5'- GGG CAC AGG CT-3' (フラグメント929) (配列番号939) 5'- GGG CAC AGG C-3' (フラグメント930) (配列番号940) 5'- GG CAC AGG CTG GGC-3' (フラグメント931) (配列番号941) 5'- GG CAC AGG CTG GG-3' (フラグメント932) (配列番号942) 5'- GG CAC AGG CTG G-3' (フラグメント933) (配列番号943) 5'-GG CAC AGG CTG -3' (フラグメント934) (配列番号944) 5'- GG CAC AGG CT-3' (フラグメント935) (配列番号945) 5'-G CAC AGG CTG GGC-3' (フラグメント936) (配列番号946) 5'-G CAC AGG CTG GG-3' (フラグメント937) (配列番号947) 5'-G CAC AGG CTG G-3' (フラグメント938) (配列番号948) 5'-G CAC AGG CTG -3' (フラグメント939) (配列番号949) 5'-CAC AGG CTG GGC-3' (フラグメント940) (配列番号950) 5'-CAC AGG CTG GG-3' (フラグメント941) (配列番号951) 5'-CAC AGG CTG G-3' (フラグメント942) (配列番号952) 5'-AC AGG CTG GGC-3' (フラグメント943) (配列番号953) 5'-AC AGG CTG GG-3' (フラグメント944) (配列番号954) 5'-C AGG CTG GGC-3' (フラグメント945) (配列番号955) 5'-TTT TCC TTC CTT TGT CTC TCT TC (フラグメント946) (配列番号956) 5'-GCT CCC GGC TGC CTG (フラグメント947) (配列番号957) 5'-CTC GGC CGT GCG GCT CTG TCG CTC CCG GT (フラグメント948) (配列番号958
) 5'-CCG CCG CCC TCC GGG GGG TC (フラグメント949) (配列番号959) 5'-TGC TGC CGT TGG CTG CCC (フラグメント950) (配列番号960) 5'-CTT CTG CGG GTC GCC GG (フラグメント951) (配列番号961) 5'-TGC TGG GCT TGT GGC (フラグメント952) (配列番号962) 5'-GGC CTC TCT TCT GGG (フラグメント953) (配列番号963) 5'-CCT GGT CCC TCC GT (フラグメント954) (配列番号964) 5'-GGT GGC TCC TCT GC (フラグメント955) (配列番号965) 5'-GCT TGG TCC TGG GGC TGC (フラグメント956) (配列番号966) 5'-TGC TCT CCT CTC CTT (フラグメント957) (配列番号967) ヒトアデノシンA2aレセプター核酸およびアンチセンスヌクレオチドフラグメ
ント 5'-TGC TTT TCT TTT CTG GGC CTC TGT GGT CTG TTT TTT TCT G GCC CTG CTG GGG
CGC TCT CC GCC GCC CGC CTG GCT CCC GGB GCC CBT GBT GGG CBT GCC GTG GTT
CTT GCC CTC CTT TGG CTG CCG TGC CCG CTC CCC GGC CTC CTG GCG GGT GGC CGT
TG GGC CCG TGT TCC CCT GGG -GCC TGG GGC TCC CTT CTC TC GCC CTT CTT GCT G
GG CCT C TGC TGC TGC TGG TGC TGT GGC CCC C GTA CAC CGA GGA GCC CAT GAT G
GG CAT GCC ACA GAC GAC AGG C GTB CBC CGB GGB GCC CBT GBT GGG CBT GCC BCB
GBC GBC BGG C-3' (FRAG. NO. 1665) (配列番号1680) 5'-CTG GGC CTC-3' (フラグメント1666) (配列番号1681) 5'-TGC TTT TCT TTT CTG GGC CTC-3' (フラグメント 958) (配列番号968) 5'-TGT GGT CTG TTT TTT TCT G-3' (フラグメント 959) (配列番号969) 5'-GCC CTG CTG GGG CGC TCT CC-3' (フラグメント960) (配列番号970) 5'-GCC GCC CGC CTG GCT CCC-3' (フラグメント 961) (配列番号971) 5'-GGB GCC CBT GBT GGG CBT GCC-3' (フラグメント 962) (配列番号972) 5'-GTG GTT CTT GCC CTC CTT TGG CTG-3' (フラグメント 963) (配列番号973) 5'-CCG TGC CCG CTC CCC GGC-3' (フラグメント 964) (配列番号974) 5'-CTC CTG GCG GGT GGC CGT TG-3' (フラグメント 965) (配列番号975) 5'-GGC CCG TGT TCC CCT GGG-3' (フラグメント 966) (配列番号976) 5'-GCC TGG GGC TCC CTT CTC TC-3' (フラグメント 967) (配列番号977) 5'-GCC CTT CTT GCT GGG CCT C-3' (フラグメント 968) (配列番号978) 5'-TGC TGC TGC TGG TGC TGT GGC CCC C-3' (フラグメント 969) (配列番号979)
5'-GTACACCGAGGAGCCCATGATGGGCATGCCACAGACGACAGGC-3' (フラグメント970) (配
列番号980) 5'-GTBCBCCGBGGBGCCCBTGBTGGGCBTGCCBCBGBCGBCBGGC-3' (フラグメント971) (配
列番号981) ヒトアデノシンA2bレセプター核酸およびアンチセンスオリゴヌクレオチドフ
ラグメント 5'-GGC GCC GTG CCG CGT CTT GGT GGC GGC GG GTT CGC GCC CGC GCG GGG CCC CT
C CGG TCC GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC CGG GTC GGG GCC CCC CG
C GGC C GCC TCG GGG CTG GGG CGC TGG TGG CCG GG CCG CGC CTC CGC CTG CCG C
TT CTG GCT GGG CCC CGG GCG CCC CCT CCC CTC TTG CTC GGG TCC CCG TG ACA GC
G CGT CCT GTG TCT CCA GCA GCA TGG CCG GGC CAG CTG GGC CCC BCB GCG CGT CC
T GTG TCT CCB GCB GCB TGG CCG GGC CBG CTG GGC CCC CCCAGCCCCG AGGCTCAGAA
GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTC
GCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA C
AGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGG
TGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TG
GCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTC
TG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CAT
CTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAG
T TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCG
GATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG
ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGC
TACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA
CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGAC
CACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG T
GCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGC
CCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TC
TATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGC
CA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATG
ATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGT
T TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGG
AGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA
TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTC
TTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTTTA CTGTGAAACA
GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTA
CTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG G
GCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAG
GAG TTCAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACG
CGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG
GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGG
GCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG G
CGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTT
CGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT AC
GTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTG
GG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGT
GGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTA
C GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGG
CCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA
CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTC
CTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA
TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTT
CAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC C
TGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGG
AGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TG
CATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATG
AA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAA
CCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAA
G AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGC
CTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG
ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATC
TAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG
CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAA
AGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT A
TAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG CCC
AGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTC
T CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGC
CATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT
GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACT
ACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC
ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTG
CTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG T
CCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGT
CCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CA
ACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGA
AT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTT
ATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTG
A TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGT
GGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC
TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAG
TTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC
TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCT
CTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA C
AAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCT
CTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AG
GATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAA
TG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AAC
TATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAA
A ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAG
TATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG
GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGTTAT
CC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGG
GCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCG
C CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCA
GAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC
CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGA
CACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG
CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCC
CTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG G
CTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTC
CAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TA
AAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCA
TC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCC
TGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATG
A GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGAT
CTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG
GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCC
TGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT
AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATT
GTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC T
CTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCT
ATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GC
TGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCC
TG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TAT
ATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAG
A CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGA
AACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC
TGTACTAAAA ATG -3' (フラグメント番号1670) (配列番号3006) 5'- GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CC
CCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGG
CG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCA
GCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCG
G CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTG
GCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC
TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCC
ACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT
TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGT
GCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC A
TCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCC
TCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CC
ACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTC
TT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCC
ACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCAC
T GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCA
TGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC
AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCC
AATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA
AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACA
GCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA C
AAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGAC
TGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AG
GCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAAC
AG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATT
ACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGC
A ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG-3'(フラグメント番号 )(配列番号
2436) 5'-CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGG
CGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGC
C CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCT
TTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC
CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTG
CCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG
CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATC
TGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC T
CTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCAC
CAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CT
TTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCAC
TG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACT
GAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATG
A TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCA
GCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA
TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAA
TTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG
CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAA
GAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC T
GCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCA
CCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AG
CTTGAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACT
GA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAA
TGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATT
A AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCA
AGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG -3' (フラグメ
ント番号 ) (配列番号2435) 5'- GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CC
CCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGG
CG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCA
GCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCG
G CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTG
GCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC
TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCC
ACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT
TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGT
GCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC A
TCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCC
TCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CC
ACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTC
TT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCC
ACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCAC
T GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCA
TGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC
AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCC
AATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA
AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACA
GCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA C
AAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGAC
TGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AG
GCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAAC
AG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATT
ACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGC
A ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG-3'(フラグメント番号 )(配列番号
2425) 5'-CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGG
CGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGC
C CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCT
TTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC
CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTG
CCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG
CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATC
TGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC T
CTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCAC
CAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CT
TTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCAC
TG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACT
GAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATG
A TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCA
GCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAA
TTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG
CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAA
GAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC T
GCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCA
CCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AG
CTTGAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACT
GA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAA
TGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATT
A AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCA
AGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG (フラグメント
番号 ) ( 配列番号2424) 5'-GCGCGTCCTG-3' (フラグメント番号1671) (配列番号1686) 5'-GCT GGG CCC CGG-3' (フラグメント番号1672) (配列番号1687) 5'-CGG GTC GGG GCC CCC C-3' (フラグメント番号1673) (配列番号1688) 5'- CGC GCC CGC G-3' (フラグメント番号1674) (配列番号1689) 5'-GGC GCC GTG CCG CGT CTT GGT GGC GGC GG-3' (フラグメント972) (配列番号
982) 5'-GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC-3' (フラグメント973) (配列番
号983) 5'-GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC-3' (フラグメント974) (配列番
号984) 5'-CGG GTC GGG GCC CCC CGC GGC C-3' (フラグメント975) (配列番号985) 5'-GCC TCG GGG CTG GGG CGC TGG TGG CCG GG-3' (フラグメント976) (配列番号
986) 5'-CCG CGC CTC CGC CTG CCG CTT CTG-3' (フラグメント977) (配列番号987) 5'-GCT GGG CCC CGG GCG CCC CCT-3' (フラグメント978) (配列番号988) 5'-CCC CTC TTG CTC GGG TCC CCG TG-3' (フラグメント979) (配列番号989) 5'-ACAGCGCGTCCTGTGTCTCCAGCAGCATGGCCGGGCCAGCTGGGCCCC-3' (フラグメント980) (配列番号990) 5'-BCBGCGCGTCCTGTGTCTCCBGCBGCBTGGCCGGGCCBGCTGGGCCCC-3' (フラグメント981) (配列番号991) ヒトアデノシンA3レセプター核酸およびアンチセンスオリゴヌクレオチドフラ グメント 5'-ACA GAG CAG TGC TGT TGT TGG GCA TCT TGC CTT CCC AGG G BCB GBG CB TGC
TGT TGT TGG GCB TCT TGC CTT CCC BGG GCC CTT TTC TGG TGG GGT GGT GCT GTT
GTT GGG CTT TCT TCT GTT CCC BCB GBG CBG TGC TGT TGT TGG GCB TCT TGC CTT
CCC BGG GCC CTT TTC TGG TGG GGT GGT GCT GTT GTT GGG C TTT CTT CTG TTC CC
GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTC
TCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT
TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGT
AGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG C
TTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCC
TTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GC
CGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGA
AT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAA
TGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGG
G GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGC
CCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAA
GCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG
GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATG
GCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG A
TTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATA
TGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TT
CTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTA
GG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTT
TTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGG
T ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGG
TTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA
GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGAT
CCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC
TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTT
CCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA A
AAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACT
TTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TA
AAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACC
CC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTG
GGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCC
T GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTT
ACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC
GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGC
TGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC
ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCT
TGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG G
GGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC CTGCTGAATT TTATTTT
GGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GG
GTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTTGG ATGGTGCT
GA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAG
TTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGG
A TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCT
TTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG
GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAG
GCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC
TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAA
CTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT T
TTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGA
TTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TG
AATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTC
TT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAA
ACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCG
T TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGT
CCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA
TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCA
AGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC
CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAG
ATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA G
CACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGC
ATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG AT
CACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCT
CT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTG
TCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAAT
G TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCAT
CTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT
GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAA
TCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG
TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTC
ACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT T
GACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTC
ATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TT
TCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCA
GT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAG
TCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATC
A TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAA
CTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT
CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTG
AGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG
AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATC
TCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT T
GTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTG
TCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT AC
TGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAA
TT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAG
TTTAAGG GGGACTTAAA CTGCTGAATT C GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGAC
CCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT AC
AGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATT
CC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGT
TCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGC
C TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAG
AAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG
GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTA
ATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA
GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAG
ATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA A
GTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATA
TTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TT
CCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCT
GA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAG
GTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTG
A GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTC
TTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC
CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGG
TGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT
GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAG
AACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT C
TGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTC
AGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CT
GATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTT
TT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAA
GAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATC
T GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATT
CTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC
TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATT
TTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA
CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAA
CAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC G
CCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCT
TCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CC
ATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTT
AT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAA
GCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTAC
A AAGCCAGAGC CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGAT
AAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT
GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTA
TGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA
TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATA
TGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT T
CTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTA
GGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TT
TTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGG
GT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAG
GTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATG
A GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGA
TCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC
TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTAC
TTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC
AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCA
CTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC A
TAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCA
CCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TC
TGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTC
CC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGA
CATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGC
A TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCC
TTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA
ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCC
CTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA
ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCT
GCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC C
ACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTG
GCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CT
GCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGT
CA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTT
GCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAG
A GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATG
GTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC
ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATT
TTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT
GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGT
ACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT A
AAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCT
TTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG AC
CTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCT
TG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTA
CTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACT
T GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATG
GAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT
GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAG
ATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C -3' (フラ
グメント番号1675) (配列番号3007) 5'- CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TA
TAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACC
CA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAG
GAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGA
G CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGG
GAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA
ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCC
CAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG
TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTT
TTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT G
GACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGG
CTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AA
CATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCAT
GA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGT
GCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCA
A AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTC
TTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGT
CTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT
GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATG
ACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC A
AGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATAT
CTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GT
GTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAAT
AG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGG
CTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTC
G GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGC
TGAATT C -3' (フラグメント番号 ) (配列番号2439) 5'- CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CT
CAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAA
TA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGC
AAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGAC
A GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTT
GATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC
CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGA
GCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT
TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGC
TGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA G
GCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTT
TTG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC AC
TGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCAC
TC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTT
GGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCA
A AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGA
TTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCA
GAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA
CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGA
GGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG -3' (フラグメント番号 ) (配列番号2438) 5'- GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TT
CTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCC
CT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGG
GGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAG
G CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACT
TCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG
GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACT
AGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG
AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGG
TGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT G
AGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGC
CAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG AT
AAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCC
TG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACA
ATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCT
G ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGG
ATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA
TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTG
CTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG
TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCT
GGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT A
AGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCA
TGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CT
GATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTC
TC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTA
CTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTC
A AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGC
ACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA
TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATC
ACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT
CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGT
CCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA T
GTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATC
TGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CT
GGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAAT
CC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGT
CCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGT
G GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC -3' (フラグメン
ト番号 ) (配列番号2437) 5'-CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TAT
AGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCC
A CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGG
AATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG
CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGG
AAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA
ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCC
AGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG T
GCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTT
TAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GG
ACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGC
TG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AAC
ATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATG
A GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTG
CGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA
AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCT
TGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA
CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTC
TATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT G
CCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGA
CTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AA
GGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATC
TC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTG
TTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATA
G AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGC
TGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG
GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCT
GAATT C -3' (フラグメント番号 ) (配列番号2427) 5'-TTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCT
CTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT T
TCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTA
GGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CT
TCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCT
TC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCC
GATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAA
T GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAAT
GACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG
GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCC
CCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT
TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAG
CCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG G
TTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGG
CGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG AT
TCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATAT
GC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTC
TGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAG
G TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTT
TGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT
ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGT
TAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA
GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATC
CTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC T
ATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTTC
CTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AA
AAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTT
TC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAA
AGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCC
C ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGG
GAAGAC GTCTGGCGAG GCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT
GTGGAGGTTC CCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACC
TAC TCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTG
GTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC TGGCTGACA
TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC TCACAATCC ACTTCT
ACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC CCTCCATCA TGTCCTTGCT GG
CCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGC
AG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AGCCAGAGC-3' (フラグメント番号 )
(配列番号2426) 5'-GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCC
CGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGC
G CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAG
CGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG
CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGG
CCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC
TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCA
CCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT T
GCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTG
CTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC AT
CTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCT
CT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCA
CCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCT
T TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCA
CTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT
GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCAT
GATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC
AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCA
ATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA A
ATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAG
CCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CA
AGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACT
GC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGG
CTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACA
G CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTA
CTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA
ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG-3'(フラグメント番号 )(配列番号2
425) 5'-GBG CB TGC-3' (フラグメント番号1676) (配列番号1691) 5'-TTG TTG GGC-3' (フラグメント番号1677) (配列番号1692) 5'-TGC CTT CCC BGG G-3' (フラグメント番号1678) (配列番号1693) 5'-GTT GTT GGG CAT CTT GCC-3' (フラグメント番号1679) (配列番号3) 5'-GTG GGC CTA GCT CTC GCC-3' (GRAG. NO:1680) (配列番号5) 5'-ACA GAG CA TGC TGT TGT TGG GCA TCT TGC CTT CCC AGG G-3' (フラグメント
982) (配列番号992) 5'-BCB GBG CB TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG G-3' (フラグメント
983) (配列番号993) 5'-CCC TTT TCT GGT GGG GTG-3' (フラグメント984) (配列番号994) 5'-GTG CTG TTG TTG GGC-3' (フラグメント985) (配列番号995) 5'-TTT CTT CTG TTC CC-3' (フラグメント986) (配列番号996) 5'-CCC TTT TCT GGT GGG GTG-3' (フラグメント987) (配列番号997) 5'-GTG CTG TTG TTG GGC-3' (フラグメント988) (配列番号998) 5'-TTT CTT CTG TTC CC-3' (フラグメント989) (配列番号999) ヒトIgEレセプターβ核酸およびアンチセンスオリゴヌクレオチドフラグメン
ト 5'-TTT CCC CTG GGT CTT CC CTC CTG CTC TTT TTT C ATT TGC TCT CCT ATT ACT
TTC TGT GTC CAT TTT TTC ATT AAC CGA GCT GT BTT TGC TCT CCT BTT BCT TTC T
GT GTC CBT TTT TTC BTT BBC CGB GCT GT-3' (フラグメント番号1681) (配列番
号1694) 5'-CCC CTG GG-3' (フラグメント番号1682) (配列番号1695) 5'-GCTCTCCTBTT-3' (フラグメント番号1683) (配列番号1696) 5'-CBTTBBCCGBGCTG-3' (フラグメント番号1684) (配列番号1697) 5'-TTT CCC CTG GGT CTT CC-3' (フラグメント990) (配列番号1000) 5'-CTC CTG CTC TTT TTT C-3' (フラグメント991) (配列番号1001) ATTTGCTCTCCTATTACTTTCTGTGTCCATTTTTTCATTAACCGAGCTGT (フラグメント992) (配
列番号1002) BTTTGCTCTCCTBTTBCTTTCTGTGTCCBTTTTTTCBTTBBCCGBGCTGT (フラグメント993) (配
列番号1003) ヒトFc-εレセプターCD23抗原(IgEレセプター)核酸およびアンチセンスオリゴ ヌクレオチドフラグメント 5'-GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT G
CC G GTC CTG CTC CTC CGG GCT GTG G GTC GTG GCC CTG GCT CCG GCT GGT GGG C
TC CCC TGG CCT TCG CTG GCT GGC GGC GTG C GGG TCT TGC TCT GGG CCT GGC TGT
GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC TCT CTG AAT ATT G
AC CTT CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA TCT CTG BBT BTT GBC CT
T CCT CCB TGG CGG TCC TGC TTG GBT TCT CCC GB-3'(フラグメント1685)(配列番
号1698) 5'-GT CCT CCT-3' (フラグメント1686) (配列番号1699) 5'-TGT GTC TGT CCT CC-3' (フラグメント1687) (配列番号1700) 5'-GTG GCC CTG GC-3' (フラグメント1688) (配列番号1701) 5'-CGT GGT TGG GG-3' (フラグメント1689) (配列番号1702) 5'-TCT CTG BBT BTT GBC C-3' (FRAG1690) (配列番号1703) 5'-GCC TGT GTC TGT CCT CCT-3' (フラグメント994) (配列番号1004) 5'-GCT TCG TTC CTC TCG TTC-3' (フラグメント995) (配列番号1005) 5'-CTG CTT GGT GCC CTT GCC G-3' (フラグメント996) (配列番号1006) 5'-GTC CTG CTC CTC CGG GCT GTG G-3' (フラグメント997) (配列番号1007) 5'-GTC GTG GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG-3' (フラグメント998)
(配列番号1008) 5'-CCT TCG CTG GCT GGC GGC GTG C-3' (フラグメント999) (配列番号1009) 5'-GGG TCT TGC TCT GGG CCT GGC TGT-3' (フラグメント1000) (配列番号1010)
5'-GGC CGT GGT TGG GGG TCT TC-3' (フラグメント1001) (配列番号1011) 5'-GCT GCC TCC GTT TGG GTG GC (フラグメント1002) (配列番号1012) 5'-TCT CTG AAT ATT GAC CTT CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA (
フラグメント1003) (配列番号1013) 5'-TCT CTG BBT BTT GBC CTT CCT CCB TGG CGG TCC TGC TTG GBT TCT CCC GB (
フラグメント1004) (配列番号1014) ヒトIgEレセプターαサブユニット核酸およびアンチセンスオリゴヌクレオチ
ドフラグメント 5'- GCC TTT CCT GGT TCT CTT GTT GTT TTT GGG GTT TGG CTT ACA GTA GAG TAG
GGG ATT CCA TGG CAG GAG CCA TCT TCT TCA TGG ACT CC TTC AAG GAG ACC TTA G
GT TTC TGA GGG ACT GCT AAC ACG CCA TCT GGA GC BCB GTB GBG TBG GGG BTT CC
B TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB
GGG BCT GCT BBC BCG CCB TCT GGB GC GTT GTT TTT GGG GTT TGG CTT GCC TTT
CCT GGT TCT CTT BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB
TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT G
GB GC-3' (フラグメント番号1691) (配列番号1704) 5'- TGG BCT CC -3' (フラグメント番号1692) (配列番号1705) 5'-CCB TCT GGB-3' (フラグメント番号1693) (配列番号1706) 5'-CT GCT BBC BCG-3' (フラグメント番号1694) (配列番号1707) 5'-GTT TTT GGG GTT TG-3' (フラグメント番号1695) (配列番号1708) 5'-GCC TTT CCT GGT TCT CTT GTT GTT TTT GGG GTT TGG CTT-3' (フラグメント
番号1005) (配列番号1015) 5'-ACAGTAGAGTAGGGGATTCCATGGCAGGAGCCATCTTCTTCATGGACTCC-3'(フラグメント番
号1006)(配列番号1016) 5'-TTC AAG GAG ACC TTA GGT TTC TGA GGG ACT GCT AAC ACG CCA TCT GGA GC-3' (フラグメント番号1007) (配列番号1017) 5'-BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TT
C BBG GBG BCC TTB GGT TTC TGB GGG-3' (フラグメント番号1008) (配列番号101
8) 5'-BCT GCT BBC BCG CCB TCT GGB GC-3' (フラグメント番号1009) (配列番号101
9) 5'-GTT GTT TTT GGG GTT TGG CTT-3' (フラグメント番号1010) (配列番号1020)
5'-GCC TTT CCT GGT TCT CTT-3' (フラグメント番号1011) (配列番号1021) 5'-BCBGTBGBGTBGGGGBTTCCBTGGCBGGBGCCBTCTTCTTCBTGGBCTCC-3'(フラグメント番
号1012) (配列番号1022) 5'-TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC-3'
(フラグメント番号1013) (配列番号1023) ヒトIgEレセプター(FcイプシロンR)核酸およびアンチセンスヌクレオチドフラ グメント 5'-GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT G
CC G GTC CTG CTC CTC CGG GCT GTG G GTC CTC GCC CTG GCT CCG GCT GGT GGG C
TC CCC TGG CCT TCG CTG GCT GGC GGC GTG C CCC BGB BCG BGB CCC GGB CCG BCB
GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC GAT CTC TGA ATA T
TGA CCT TCC ATG GCG GTC CTG CTT GGA GBT CTC TGB BTB TTGB CCT TCC BTG GCG
GTC CTG CTT GGB-3' (FRAG: 1696) (配列番号1709) 5'-TCG TTC CTC TCG-3' (FRAG: 1697) (配列番号3001) 5'-BGB BCG BGB C-3' (FRAG: 1698) (配列番号1711) 5'-TGB BTB TTGB-3' (FRAG: 1699) (配列番号1712) 5'-GCC TGT GTC TGT CCT CCT-3' (フラグメント番号1014) (配列番号1024) 5'-GCT TCG TTC CTC TCG TTC-3' (フラグメント番号1015)(配列番号1025) 5'-CTG CTT GGT GCC CTT GCC G-3' (フラグメント番号1016)(配列番号1026) 5'-GTC CTG CTC CTC CGG GCT GTG G-3' (フラグメント番号1017)(配列番号1027)
5'-GTC CTC GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG-3' (フラグメント番号1
018) (配列番号1028) 5'-CCT TCG CTG GCT GGC GGC GTG C-3' (フラグメント番号1019) (配列番号1029
) 5'-CCC BGB BCG BGB CCC GGB CCG BCB-3' (フラグメント番号1020) (配列番号10
30) 5'-GGC CGT GGT TGG GGG TCT TC-3' (フラグメント番号1021) (配列番号1031) 5'-GCT GCC TCC GTT TGG GTG GC-3' (フラグメント番号1022) (配列番号1032) 5'-GBT CTC TGB BTB TTGB CCT TCC BTG GCG GTC CTG CTT GGB-3' (フラグメント
番号1023) (配列番号1033) ヒト高アフィニティーIgEレセプターオリゴヌクレオチドフラグメント 5'-AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCT
CCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT TTTATGTGT
T TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT AACCTCACTA AGGT
TCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT ATAGGATTAT TGTGAAAAAT
AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA TGTTTGGTAT TCAGAATTAG TTGCT
GCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT TCTAAGTTGT AAACTAAATA GTTGTACACA
GATTGACAGA TTAAGAAAGG CTTGTGATTG TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGAT
TCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG T
TGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACC
AGA TATGATACAG AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG AT
CTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG GATCTTCATG TGGAATGACT GGTT
TCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA TGATAGAATG GTTCCTCAAG
TGCTTCAGAT GTGAAGTGGG TTTAAATATA CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATA
AAATA GGACACTCAT TTAAAAGCAA TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT
TTCATTTCCA GTATTATCAT TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAA
AAAC AGAAGAATTA GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG A
GATCATGTT GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATTAT
ATG GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTCC TGTGTTCTGA GCCAGATTAG GG
CACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT CAGACAGCGG ATCATCAG
TG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT AAACAAGAAA AGC
GTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TTGCTAGCCA TGCTCCTGAA TATGTATAA
A CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA TTTTATGTGT TTGAACCCCA AATT
AGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT TAACCTCACT AAGATTCAGT TTTCCTGTTT
ATAAAATGTA GATAGTGATA GTATGTACTT TATAGGATTA TTGTGAAAAA TAAATGAAAT ATCAG
ATTTA TTTAGGATAA CACCTGGCAT ATGTTTGGTA TTCAGTAATT AGTTGCTGCT GTTTTATTCT
GCTCTCCCTT GCATCCCACT TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAA
GAAA GGCTTGTGAT TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA G
GTGGGATAG GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCCCAGTTGG GCACCATCCT GAATATT
ATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTTA ACCAGATATG ATACAGAAAA CA
TTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA GTAAGCAC
CA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACT
GTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA ATGAATTTGG GGAGCAGCT
G GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA CATGTGCAAA CTATTGGGCA TTTC
CCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG
GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA TTTGCTCTGG CATCTTCCAG AGTGCAAATT TCCTA
CCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG
ACGGTTGGTC CTTAAAATTC CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGA
GATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT T
AGCAGGTGA GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCTTT CCTCTCA
CTA TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT AC
TTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGATTCATTG CATTCTCTCA AGTCATTC
TC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT TCTCTCTCCT AGA
CACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TTATTATTGC CATTTTATAA TTGAGGATG
C TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA CTGGATTTCA ACGTAAGTTC CTTG
GATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT TTTGTTATCA CCATGTATCT ACTTCTTTGG
TCTCTGTTCA AATTTGCACT ACATCCCCTT GTTCCAGGAA GCCATTCAAG ACTGACTTTC TTAGT
GCCTC TCACTACTTT CTGGAACTGA CATATGTTTT TCACTCTGTA TATACTTACA ATTAAATAGT
CATAAATATT CAGAGCTTGG AGAAACCTTA TATTTCATCC AGTCCAGTAA ATTTATCCAT CCATAA
TTCA CTCATTCATT CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGTT T
CTACCTCAA AAGAGATTGC AGTCCTCATT TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGA
GTC AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTTTAAA TCTCCTGCAT ATGTGTCCTG TC
TTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA AATCAAAA
CA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA TATTGCTTCG TTT
GTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TCTCTCTACA TGTCTTTTCA TATTTTTAT
C TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC TCCATGGAAT AGAATATTTA AAGG
AGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT CTTTGAAGTC AGTTCCACCA AATGGTTCCA
CAATGGCAGC CTTTCAGAAG AGACAAATTC AAGTTTGAAT ATTGTGAATG CCAAATTTGA AGACA
GTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTTC
AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGG
GAAA AAACAGGTTA TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTTTTAAG A
CCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGG
TGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA AA
AATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGC
TG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGC
CCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCC
T GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACTTG TATGCCTTCT TTCAATATTC TAGT
CATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC TATCTTTTCT GCCTAGATTC AGGTATATAT
TATGTGGTCA AACAGCATGA CATATATGTG AACATTTCAA AGAGCTGTGT ATCTGGAATA GGATC
AAAAG GTTTGACTTA AAGTTTTGCT CTGCATAATC CATATGGCAG GACCTGAATA TTAGGTTGTA
CTCTTCGTTA TGAAACATAT CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATA
TTTC ATGCTTGTTT CATTTTTATC ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA T
GTGGCTTAA TTAGCAAATG TTGAATAAAC AAATTAATGA TTTTGAATAG TGACCAATAG GTCTCTT
TTA TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG TAAATTCCAA AC
ACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGTT CTAGAGAAGT CCTAAAGG
AT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTTTCAAAA TTCTCCTTTA ATG
AATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTGATTCT TGTCTTTCAC TGACTCATT
A GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT TGCTACCAAC TCCTAAATAC TGTG
TTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG TCCCTGACTT CTTGGAGCAC AGAGCAGTAT
GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTAA TTTAAATTAT ACATGTTTTG AAGAA
GTTTT TTTTTGACAA CTATAATTAA CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA
AATAGACACT CTCCTAAGCT AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC TAGAAC
TAGC AACAGAAGAT CTGAAAGGAA TTCTGGCTTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA G
GTCCGAGAG GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGA
CAG GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTTA TGAGCCAAAA AGTGAGTTAA TG
ATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCTTTTCTC TATTCATTCT CTCTCTCT
TC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC CTTCAGGCCT CTG
CTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT TGGAGGAACT GGGATGTGT
A CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC TGGTATGAGA ACCACAACAT CTCC
ATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC TACTGTACGG GCAAAGTGTG GCAGCTGGAC
TATGAGTCTG AGCCCCTCAA CATTACTGTA ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCAT
CCATA GCAGGGGAAG GAAGAGAGAA CTTCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA
CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCA
ATCT CTGTTTCAAA GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT T
TTATGAAGA TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCAT
AAC AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT TT
ATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA GCCCATTC
CA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT GTGTATTGAG GGA
GGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAAC
T GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG TATTCACTTT TGAAGGAGAA AGTT
AGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT TTAAAAAAGC ATGAGGTCAA AATACATAAT
TAAGTCCTAG CAGTTCTCTG TTAACTAATT TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTT
CCAGT ATCTTCATCT GTAAAACAGA ATATTTGGTC TAGATTCCAT TAGAATCATT TGATAACTTA
AAAAATATAT TGATGCTCAT GTCTCATTTC TTGAGATTCT GATTTAATTG GTTTGGGGTG CAGCCT
GGGT ATACGTATTT TTCATAGGTC TTTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC T
TGTCTAGGT GATCTTTAAA TGATTTCTGG ATGTAATATT CTGAGGCTCT ATAATTTGAG ACTAATC
ACA AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACAA AATAATAGAA TTGGAAGGCA AT
TTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAAGAAATG ATGATTGATT GAGTAATA
GG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC CTTAATTATA TGTGAATTCT GGT
CTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC TGGGCACGGC ACACTGGCT
A CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC AGGGAGCACC AACAGAGCAA CTCA
ACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT GGATGCCACA TCACGCTAAA AATGAAGGAC
AAAGCTTGGT CTTTCTCTTA GGGAGGATGA AACTCTGAAC CTCATTTTTC AGTTCCCAAG ATGAA
TTATG TTTCTCATTG CATCTGTGTT CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTTTT
TATCCCATTG TTGGTGGTGA TTCTGTTTGC TGTGGACACA GGATTATTTA TCTCAACTCA GCAGCA
GGTC ACATTTCTCT TGAAGATTAA GAGAACCAGG AAAGGCTTCA GACTTCTGAA CCCACATCCT A
AGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTTGCAA CATTAGTTTT TTTCCAG
CAT CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCAATAT ACATAGAAAC GTCTGTGCTC AA
GGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTAAGTGGC ATGTAATAGT AAGTGCTC
AA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATTCAT TTATTAGCAT TTGTAAAAGA GAT
GTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC TGAGTATTCA AGGCTTGCT
A GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA GTTCTAGATT GGAAATGTCC TCTC
TTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC ATAGGAGGAT GCCAGTGAGG TGGATCATTT
TTATGCTTCT TCTTCAGCTT ACTAAATATG AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTC
AAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA
AATTTATATC TTGAACTTAT GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAAT
TCCA GCTAATAATA ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT G
GGCAAAAGA ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATTTTATGTC TTCATCATAG TCATTGG
AGG CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC TACTAAGAGT CTCCAGCATC CTC
CACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA GTAAGCACC
A GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTG
TTCTTC GCTCCAGATG GCGTGTTAGC AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG
AATAGAATAT TTAAAGGAGA GAATGTGACT CTTACATGTA ATGGGAACAA TTTCTTTGAA GTCAG
TTCCA CCAAATGGTT CCACAATGGC AGCCTTTCAG AAGAGACAAA TTCAAGTTTG AATATTGTGA
ATGCCAAATT TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTG
TGTA CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG C
CAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA TTATAAG
GAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA TGCCACAGTT GA
AGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA TGAGTCTGAG CCCCTCAA
CA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA ATTTTTTATC CCATTGTTGG TGG
TGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC AACTCAGCAG CAGGTCACAT TTCTCTTGA
A GATTAAGAGA ACCAGGAAAG GCTTCAGACT TCTGAACCCA CATCCTAAGC CAAACCCCAA AAAC
AACTGA TATAATTACT CAAGAAATAT TTGCAACATT AGTTTTTTTC CAGCATCAGC AATTGCTACT
CAATTGTCAA ACACAGCTTG CAATATACAT AGAAACGTCT GTGCTCAAGG ATTTATAGAA ATGCT
TCATT AAACTGAGTG AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CATTGGTTGA
ATAAATGAGA GAATGAATAG ATTCATTTAT TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAA
TAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA TCT
CAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATA
G GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG AAGTCTTGGA AATA
TCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT CCCCACCACT GCATACATGG
CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA CACAAATTCT GACTGCTATG ATATG
CCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG ATATTTCACA CATTGAGGGA GACATTTTTT
CATCATTTAA AGCAGGTTAT CCATTCTGGG GAGCCATATT TTTTTCTATT TCTGGAATGT TGTCAA
TTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG C
AGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATC
CAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA AT
TGTAGTGA TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGG
AG CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA TAT
ATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT TATAAGAAT
C ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT CTTGTTAAGG GGCT
ACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT AAGCTTTTCA AAGGTGCAAT TGGAT
AACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC AAGTGGGGAC AATTCCAGAA GAAGGGCACA
TCTCTTTCTT TTCTGCAGTT CTTTCTCACC TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTT
CTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCAGGAGTC TCAAATTTTC TTATTTCATA T
TAGTCTTTA TTTAGTAGAC TTCTCAATTT TTCTATTCAT CACAAGTAAA AGCCTGTTGA TCTTAAT
CAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GG
TAACCCAT TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATA
AT ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG CAA
ATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT TTTTTCTACC CTCAGTCAC
T TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG ATTTAGGCAT GGAT
CCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG TACTTTCCAT GTGGTTCTCT
CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG AAATAGATTT TCTCACATTA GAAGC
TCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT GTGTATGTAG ATCTCTGGCT TCTGGGTCTG
ACATGTGCTG AGGGACACAT ATCCTTCACA CATGCTTTTA TAAATACTTG ATAAAGTAAC CTGCTT
CTTG ATTGGTCTTT ATAATCCATA AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA G
TCCCATCTA GCTATTCAAA GCCATTCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTAC
TGA CAAAATATAT TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TT
TATTTTCA GTTTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGA
AT AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC AGG
TGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA AGATTTGAA
T TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC TGTCTGTCGA GAATGTTGCA CAGG
GAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTCACAG TGTGCCTGCA TTTGAAGTCT
TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT GAAGTCGGCC TCATCCCCAC CACTG
CATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC
TTTGACTAGA GTAAGGGTTG GGTCTAGAAA AGAATATTGA GTTGCATCAA CTGTTTTCCC ACTTGG
ATTC ATGAGAGGTG TTAGGTCCTT TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC C
TTTTGGGAA GAGCCAGAAG CATTTCCTCA TAAAGACTTT AAATTGCTAG GACGAGAATG GCCAACA
GGA GTGAAGGATT CATAACTTTA TCTTTACTTA GATGTAAAGA ACAATTACTG ATGTTCAACA TG
ACTACATA CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCA
AT TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC TAG
GACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG GGAAAATTT
T TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC ACAAATTCTG ACTGCTATGA TATG
CCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTCACAC ATTGAGGGAG ACATTTTTTC
ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT GTGAGTATAT ATCTATAATT GTTTC
TGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC AGATCTAACC AGTTGTTTAT TCCCAGTATT
AAGATGATAT TTATAATTCT TAATTATAAA TATATGTGAG CATATATAAC ATAGATATGC TCATTA
ACAA CAACAAAAGA TTCTTTTTAC AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTTTTATCC C
ATGAGAAAC CTGAATCTAA TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAATTG
AAC CTAAACTTTC AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TA
TGATAAAT ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCAC
AC CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA GAC
CAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT GTGATAGTG
C ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA CCTGGAAGGC AGAG
GTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT AAGTGCGAAC TCTGTCTCAA
AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG AAAAATGAGG AAAGAGATTG CTGGG
GTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC CTTCTATGCC CTAGAAACTC TTTTANGGTA
TTTTCTCCTG GTATCTCTTT TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATA
ACGG TATATACTTT TTAAAGGTCT AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT T
GCTAACCTT GACACACATA GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATC
ATT CCAAAAGCTT CCCTGTGTAT CTTTGTAACT CTTTCTTCCT CCCTCCACTC CTTGTCCTCT CG
TTCCCAAG AAAACATTGA TCTGCTTCCT GTGAATATAA ATTAACTTAC ATTTTTTAGA GCTTTATA
TA AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TTATTTTGAG ATTCTTCAAG TTT
TTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAATTCTAG ACTATGTCAC ATTGACTTT
G TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG AACCTGTACC TCTG
TTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACACAGCT TATTAGGTGT CTCTCAACCC
ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA TTTGTGCTAT TGACTTATAT NTATA
TNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT GTACNTTTTC ATAATTACGC TATNTNCACA
TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGACA CGTGTTTCTT GCCTAAAGGG GCTGAT
GGAA GACNCACATA CNAATAGACG ATTGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT C
CTGATGTTG CTCGGACAGT TACTACNCCA AGAGTACCCC CTGCATTGTC AGGGTTAGCA TCTCCTG
GAA GCCTCATGTA AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TT
TAGCAAGA CCCTCATATG ATTCATATAC ACTTTTTTTT TTTTTTTTTA GATGGAGTCT CACTCTTG
TC GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC AAG
TGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG CTGGCTAAT
T TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT TGAACTCATG ACCT
CCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA CATGAGCCAC CACACCCGCC
TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG AAAATAAGAA TAAGAAAATA TTGGG
CTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT ACCCCAAATT TTACCTATGT TTGGAAGATG
GGGTTAAAAG GACACATTGA AAACAAGAAC TCATTGTGGC TTTTTTTTCC TCCTTTTTGA ACAGTT
TTCT ATTTCTGGAA TGTTGTCAAT TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC C
CGTTTCTGT CTTTGTCCAT CCTTGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTCTTAA GGGAAAC
ACA TCTTTGTCTC CTATATTACT TGTGAATGTG GATATATGAT TTTGTTTCAA TCTATTTTGT GT
CCTAAGGC TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATAC
AT GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TTGTCCTTGT AGG
CATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAGGAGAA TATTTGAGGA AAGACCGTA
C GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT CATTAAACAA TGCG
GACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCAATGT GGAATTTACT GGATGCATCC
AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAGT GTTCT
TCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG
GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGA
AATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGTA TGTATTTTTT TTTGTGTGGG A
AGACTAAGA TTCTGGGTCC TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCT
TTT CTGTAACTTC TATTACACAG TATAGTGGTT CTGTAAGTTC ACACAGCCCA GGGAGATGCT GG
CTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCT
CT GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA CTT
TAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA ACTTTTGGG
G CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT GTTCAATAGG AAATTGTAGT GATG
ATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA CAATCTGTGG AGCTGGGGAA
GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA ATCTTGAATG ACAGGTTAAC GAATT
GGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC TGAAACATTT CTTCCAGAAA ATAGTTTCTC
CAAGTTTTAT TACTTTGGTT TACAAATCTC ACATTTAAAT CACATTTTAT ACCATAAGTA GCACAC
ATTT CATAATATTC CTCTGAATGA GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA A
GTGTGTGGA GCATGAGAGA TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTT
GTT TTCTGCCCCA GAACTAGCCG CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TT
CCTTTCCA ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TTCTGATTCA TGACTACCAA ATGTTTTC
AC TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT GCC
CATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA GTCTAGCCA
C CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC TCAGCACTTT GTGA
GGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC TGGCCAAATG GCAAAACCAA
ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA CTAAAAAATA CAACAAAACA AAACA
ACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCGTGGTGGC AGGTACCTGA GGTTCCAGAT
ACTTGGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATC
ATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACTTCCCAG CACATTGGGA GGCCAAAGCT G
AAGAATAAT TTGAGGTGAG GATTTGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTA
AAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AG
GCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTC
CA GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT CTC
TTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG TCATTGACT
G ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG GAAATGAAAG AAAT
AATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG TAGATGAGGT AAGTCTCTTG
AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA TGAAATGATT TTTCCCTTAT CAGGT
TCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT ATTCAGCTAC TTACAGTGAG TTGGAAGACC
CAGGGGAAAT GTCTCCTCCC ATTGATTTAT AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCC
AAGG ATCCAGAAGG CCAAGGTTTT GTTAAGGGGC TACTGGAAAA ATTTCTATTC TCTCCACAGC C
TGCTGGTTT TACATTAGAT TTATTCGCCT GATAAGAATA TTTTGTTTCT GCTGCTTCTG TCCACCT
TAA TATGCTCCTT CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTTTA TATTATGACC AC
ACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAA
AT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG GTT
CTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGTTGGGC ATGATTTGTA CCATCCACC
C ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT ATAACTTCCT ATGC
AAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACATGAA GTTTTATAAA GATCTGTATA
ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT TTGCAGATTG ACAAGTAGGA AGTGG
GGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG TAAATAGGTT AAAAACAGGG AAATTATAAG
TGCAGAGATT AACATTTCAC AAATGTTTAG TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGAC
CTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG A
GTAACTGGT AGATTTTGTT AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACA
TTA AGCGTTTGAG TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TC
GGGCGCGG AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTC
AG TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA AAA
ATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA GGAGAATCG
C TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC TCCAGCCTTG GTGA
CAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AAAAGTCAGA AATCTGAAAA
GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT TTTTGGCTTT GATTTTGGGG AGACA
AAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTTCTGGTAA AGATAAAATT
TGATACACGG TTTGGTGTCA TTATAAGAGA AATCATTATT AAATGAAGCA AGTTAACACT CTAAGA
GAAT TATTTTGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA C
TAAGGATAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAG
AGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT AT
CTCTAGGC TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGG
CA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT TGT
GCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA TATGTGCGA
A ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATTCTG TTTA
TAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATAAGAG TCCTACAGAT GGACTGAAAA
AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT TACATTTTAT GTATTGAGGA TGCCA
AGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT AGATTGTGAA AGTGATCACG ACAATCACAC
AACAAATAAT TAAGTGACTT GGTATGCTTT ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATT
TTTC TAAAATACAA TTTTGTTTCT CCAAATTTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG T
GTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGC
ATG GATGTTCACA TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TA
TATCTTTA CAGTTGTATA GTATATGATA TCTCTTTTAT TTCACTCAAT TTATATTTTC ATCATTGA
CT ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT CTCAAGATCA TTCTGAGAGT TGC
CCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC TGGGGTTCT
C TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA ACTTCAATGT CATCTTCTCC ATGA
AGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTTGCTC CATAACTACT CTATCCCACG
ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC TCCTTATGTA TTCTCAATTA CCTGT
ATTTG TGCAATAAAT TGGAATAATG TAACTTGATT TCTTATCTGT GTTTGTGTTG GCATGCAAGA
TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCA
GTTT CTGAAGTCCT CCTTTTCATC AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG C
CAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAA
TGT AAGGACAATC ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AG
CATGAGTC ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTT
TT TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC TAA
CTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTAGGATT TTTGGTAATC ACAATTACT
T AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT TTTCAAAGGA GTAG
CTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG CCTGTAATCC CAGCACTTTA
GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA GACCATCCTG GCTAACACGG TGAAA
CCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG CGGGCGCCTG TAGTCCCACG
TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGAT
AGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA A
AAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAA
ATG CTAATCAAAG GGTTTTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CC
GAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATAC
TA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG CTG
GAGAATC ACGTGAAC-3' (フラグメント番号 )(配列番号2505) 5'-AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCT
CCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT TTTATGTGT
T TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT AACCTCACTA AGGT
TCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT ATAGGATTAT TGTGAAAAAT
AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA TGTTTGGTAT TCAGAATTAG TTGCT
GCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT TCTAAGTTGT AAACTAAATA GTTGTACACA
GATTGACAGA TTAAGAAAGG CTTGTGATTG TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGAT
TCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG T
TGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACC
AGA TATGATACAG AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG AT
CTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG-3' (フラグメント番号 )(
配列番号2500) 5'-GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAG
CAAGGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA CTGTCCCTG
T CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA TCTTTGCAAA TGAC
AAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT TAATATCAGA TCCTGGAAGA
AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA GTAAAGGAAT CCTGGAGAAA GCCCC
TGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT GGGAAATTAT AATATTAAAA GTAAACAAAA
GCTAGGAAGT AAAATAAAAT AAATTATATG GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCC
TTCC TGTGTTCTGA GCCAGATTAG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA T
TTCGCTGGT CAGACAGCGG ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGA
TCA GCAGGAAATT AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TT
GCTAGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTA
GA TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT TAA
CCTCACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT TATAGGATT
A TTGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT ATGTTTGGTA TTCA
GTAATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT TTTCTAAGTT GTAAACTAAA
TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT TGTGCTAGAC CTATGCCTCT CTCTC
ACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA ATATTAAATT
GCCCAGTTGG GCACCATCCT GAATATTATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGG
GTTA ACCAGATATG ATACAGAAAA CATTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG C
CTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCC
CCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GG
AGGCCCAA ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAG
GA CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGG
CAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA TTTGCTCTG
G CATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TTTC
TTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC CATGGATGTA GATCTTATCC
CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGG
ACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA GTCCTCTGTT CTTGTTCCCT TGGTGTATCA
ACATGTCTGG GCATTGCTTT CCTCTCACTA TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGC
ATGA ATCTGTTCCT TGGCCAGACT ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC T
GATTCATTG CATTCTCTCA AGTCATTCTC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACAT
ATA CATGTCTCAT TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TT
ATTATTGC CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGG
AA CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT TTT
GTTATCA CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT GTTCCAGGA
A GCCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA CATATGTTTT TCAC
TCTGTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG AGAAACCTTA TATTTCATCC
AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT CACATAATAA ATATTTAATG TAACA
ATGGT TGAACATGGC AGACAGTGTT TCTACCTCAA AAGAGATTGC AGTCCTCATT TACAGATACT
GAATTGAAAT TAACAGAAGT AGAGTGAGTC AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTT
TAAA TCTCCTGCAT ATGTGTCCTG TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC T
AATTTCTCC TTCCCCTAGA AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCA
CTG ATTGTCAGAA TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TC
TCTCTACA TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAAC
CC TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT CTT
TGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC AAGTTTGAA
T ATTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGA
GTGAAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT
GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA TTCCAAGGGT TAGGACACCA GAGTG
GGATT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT
CCCAGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAAC
ATGG TGAAACCCCA TCTCTGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG C
ACCTGTAGT CCCAGGTACT CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTT
GCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AA
AATAAATA AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACT
TG TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC TAT
CTTTTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACATTTCA
A AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTTGCT CTGCATAATC CATA
TGGCAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT CTGGGTACAT TTCCTTATGT
CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT CATTTTTATC ACTCCTACTG CCAAC
AAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA TTAGCAAATG TTGAATAAAC AAATTAATGA
TTTTGAATAG TGACCAATAG GTCTCTTTTA TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTT
TCAA CCTCCATATG TAAATTCCAA ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT G
GAGTAGGTT CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATA
TTT CCTTTCAAAA TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA AT
GTGATTCT TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGT
AT TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG TCC
CTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTA
A TTTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA CACTAGAACT GGGA
AGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT AAAATTCCCA AGAAAGACTG
TTTATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT CTGAAAGGAA TTCTGGCTTT CAAGT
GTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG GCTTTGTGGC CCCAGACTGA CTTTTCAGGA
GGGGAAAGGA TTTATCAATA CACAAGACAG GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCAC
TTTA TGAGCCAAAA AGTGAGTTAA TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT C
TCTTTTCTC TATTCATTCT CTCTCTCTTC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTC
AGA CTGGCTGCTC CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GT
GCCATGGT TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGT
AC TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC TAC
TGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA ATAAAAGGT
G AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CTTCTGAGCC TGAG
CAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG
AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA GCCTTGACTT GTTAAATGGT GATAG
TAATA CCTGCTTGCA CTATGAAATT TTTATGAAGA TTAATGTGGT AATATTTGTG AAATGACTTT
GTAAACTGTT AAGCACTACC CAAGCATAAC AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTG
TTGC TCCTGGGGGA ACACTTATAT TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA G
GATATAAAG AGCTTGAGGA GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGT
AAG CTGTGTGCCT GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GG
ACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGA
AG TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT TTA
AAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT TGAGACTGA
A GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA ATATTTGGTC TAGA
TTCCAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT GTCTCATTTC TTGAGATTCT
GATTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT TTCATAGGTC TTTCACATAA TGGTA
ATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT GATCTTTAAA TGATTTCTGG ATGTAATATT
CTGAGGCTCT ATAATTTGAG ACTAATCACA AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACC
ACAA AATAATAGAA TTGGAAGGCA ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT G
TAAGAAATG ATGATTGATT GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCA
CCC CTTAATTATA TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TC
TTCCCCTC TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCT
CC AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT GGA
TGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA AACTCTGAA
C CTCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT CCACTACAGC TCCG
CGTGAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA TTCTGTTTGC TGTGGACACA
GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT TGAAGATTAA GAGAACCAGG AAAGG
CTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA
ATATTTGCAA CATTAGTTTT TTTCCAGCAT CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCA
ATAT ACATAGAAAC GTCTGTGCTC AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG G
TTAAGTGGC ATGTAATAGT AAGTGCTCAA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATT
CAT TTATTAGCAT TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AG
AATGCTTC TGAGTATTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATG
AA GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC ATA
GGAGGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG AACTTTCAG
T TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATT
CCTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT GTCTTGTATC TTTATACAGC
ACCTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA ATAACCAAAA CCTTCGGCTC TGAAA
ACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA ACTAGACAGT TTTGGTTTAT TTTCCCTTTC
ATTTTATGTC TTCATCATAG TCATTGGAGG CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAG
TTC-3' (フラグメント番号 )(配列番号2501) 5'-TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG CCT
TAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCC
T ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC AGTCCCTCAG AAAC
CTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA GAATGTGACT CTTACATGTA
ATGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT CCACAATGGC AGCCTTTCAG AAGAG
ACAAA TTCAAGTTTG AATATTGTGA ATGCCAAATT TGAAGACAGT GGAGAATACA AATGTCAGCA
CCAACAAGTT AATGAGAGTG AACCTGTGTA CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGC
CTCT GCTGAGGTGG TGATGGAGGG CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG G
ATGTGTACA AGGTGATCTA TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACA
TCT CCATTACAAA TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AG
CTGGACTA TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTA
CA ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC AAC
TCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT TCTGAACCC
A CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT TTGCAACATT AGTT
TTTTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG CAATATACAT AGAAACGTCT
GTGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG AAACTGGTTA AGTGGCATGT AATAG
TAAGT GCTCAATTAA CATTGGTTGA ATAAATGAGA GAATGAATAG ATTCATTTAT TAGCATTTGT
AAAAGAGATG TTCAATTTCA ATAAAATAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAA
AAAA AAAAAAAAAA AAAAAAAA-3' (フラグメント番号 )(配列番号2502) 5'-TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAA
GTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG AAGTCTTGG
A AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT CCCCACCACT GCAT
ACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA CACAAATTCT GACTGCTATG
ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG ATATTTCACA CATTGAGGGA GACAT
TTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG GAGCCATATT TTTTTCTATT TCTGGAATGT
TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTG
CCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC C
TATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACT
GAA ATTGTAGTGA TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA AT
CTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAA
CA TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT TAT
AAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT CTTGTTAAG
G GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT-3'(フラグメント番号 )(配列番号2503) 5'-AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC AAG
TGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC TTCTCAACT
C CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCA
GGAGTC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC TTCTCAATTT TTCTATTCAT
CACAAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGT
ATAAA GAGAATCATC AATGTCATGA GGTAACCCAT TTCAACTGCC TATTCAGAGC ATGCAGTAAG
AGGAAATCCA CCAAGTCTCA ATATAATAAT ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAA
TGGA CACAGAAAGT AATAGGAGAG CAAATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA A
GGTATTATT TTTTTCTACC CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGA
TGA AACTTTATTG ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CT
ACTTGCTG TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACT
GG AAATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT GTG
TATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA CATGCTTTT
A TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA AGCTGTGGGA TGCT
TCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA GCCATTCCTT CATTGTATTC
TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT TCAGATACAT TTCTATGTTA AAAGG
ATTGT GAGATGCATA GGTAAATGTG TTTATTTTCA GTTTTACTTG TCAACATAGA TGAATGAGAA
AGAACTTGAA AGTAACACTG GATTAAGAAT AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCC
CATC TAATCACTTG GATAGTGTTC AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG T
TTCTTGGTG ATTACAATGA AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCT
TTC TGTCTGTCGA GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AA
TTTCACAG TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTA
TT GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA GTT
CCTGGGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA AGAATATTG
A GTTGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT TAAAAAACAT GGTA
GATAAA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG CATTTCCTCA TAAAGACTTT
AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT CATAACTTTA TCTTTACTTA GATGT
AAAGA ACAATTACTG ATGTTCAACA TGACTACATA CATAAAGGCG CATGGAGAAA AGTATTGGCC
TTCCATGCAT TAGGTAGTGC TTGTATCAAT TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACG
TGTG GATCATTTCT CAGGACAGTC TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT T
AAAAAATGA TACAATCTCG GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGT
AAC ACAAATTCTG ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TA
TTTCACAC ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATAT
TT GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC AGA
TCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA TATATGTGA
G CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC AATTAACGGT GGGT
TAAACA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA TACAAGTTAA ATGACTTGCC
TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC AGAATCCAAC TCCAGGAACA TACTT
CTAGC ACTATTCATC AATAAAGTTA TATGATAAAT ACATACAACT TTATCTGTCA ACTAAAAATA
ACAACAGAGG CTGGGCATGG TGGCTCACAC CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTG
GATC ACCTGAGGTC AGGAGTTTGA GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA A
TATAAAAAA TTAGCTGAGT GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGG
AGG CTTGTTTGAA CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CC
TGGGCAAT AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCA
TG AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC CTT
CTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT TCTATCTGG
A AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT AATTGACATA TATA
AATTGC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA GACACACATG AAAACATCAC
CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT CCCTGTGTAT CTTTGTAACT CTTTC
TTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG AAAACATTGA TCTGCTTCCT GTGAATATAA
ATTAACTTAC ATTTTTTAGA GCTTTATATA AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGC
ACAG TTATTTTGAG ATTCTTCAAG TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT T
TAATTCTAG ACTATGTCAC ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTC
AGG ACTCTCCTTG AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AA
ACACAGCT TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTG
AA TTTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT GTA
CNTTTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGAC
A CGTGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG ATTGCAGTAG AATG
AGAGTG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT TACTACNCCA AGAGTACCCC
CTGCATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA AATGAAGAAT TTCATGCTCC ATCCA
GGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA CCCTCATATG ATTCATATAC ACTTTTTTTT
TTTTTTTTTA GATGGAGTCT CACTCTTGTC GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCA
CTGC AACCTCTGCC TCCCGGGTTC AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT A
CAGGTGCAT GCCACAGTGG CTGGCTAATT TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTG
GTC AGGCTGGTCT TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GG
ATTACAGA CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTAT
AG AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT ACC
CCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC TCATTGTGG
C TTTTTTTTCC TCCTTTTTGA ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT TATATCTGAA AGGA
GAAATG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT CCTTGAAAAG ATAAGAAGAA
CAGAGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC CTATATTACT TGTGAATGTG GATAT
ATGAT TTTGTTTCAA TCTATTTTGT GTCCTAAGGC TTTTTGCAAC AGAAGTTGGA TATATCATTA
GAAACATAAA TTGTACCATT TAACATACAT GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGT
GTCC TACACCGGCA TTGTCCTTGT AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA T
TAAGGAGAA TATTTGAGGA AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAA
GTA ATATATGCTT CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GA
AGCAATGT GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGC
AA GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA ACA
CTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGG
C CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCC
ACTGTA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC TAATGTAAGT AAGAAGCCCT
CTTCTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC TATTACACAG TATAGTGGTT CTGTA
AGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT
TAAAGTTATC TACTGCAAGT GACGATCTCT GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGT
GTGT GTGTGTGTGT GTATGTGTCA CTTTAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG G
AGATGCTAT AAGAAAATAA ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTT
GCT GTTCAATAGG AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GT
GTCACTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATA
AA ATCTTGAATG ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC TGA
AACATTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC ACATTTAAA
T CACATTTTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA GGGTTGGGAT AATA
GGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA TGGATGTACA GAAGGCTTGT
GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA GAACTAGCCG CCTATTCCTG TTTCT
GTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA ACTTGCTCTA AAACCTCAGT TTTCTTTCCT
TTCTGATTCA TGACTACCAA ATGTTTTCAC TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACC
ACCA GACCTTGTGC TCATGTACTT GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC C
ACTTTCCTG AGGCATTCAA GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGT
CAC GCCTGTAATC TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AA
AACCAGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTC
TA CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCG
TGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAG
A GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACT
TCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG GATTTGGAGA CCAGCCTGGC
CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCT
GTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA
GTGAGCCAAG ATCGTGGCCA CTGCACTCCA GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAA
ATAA AAGAAATTTA AAAAATCACT CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA G
GAATAACCT CACCAACTTG TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTG
GTT TGGTTTTCTG GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AA
GACAAAAG TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGA
TA TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT ATT
CAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT AAGAATCAC
G TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT GTTAAGGGGC TACT
GGAAAA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT TTATTCGCCT GATAAGAATA
TTTTGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT CTATTTGTAG ATATGATAGA CTCCT
ATTTT TCTTGTTTTA TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG
ATTTAACTGT TTGATTATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAA
ACTT TGACAGTTTG ATAATATTTG GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT A
CAGTTGGGC ATGATTTGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATT
ACT TACACTATAT ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AA
GACATGAA GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATT
AT TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG TAA
ATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG TGAAACATT
T GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATG
GTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT AACAAATTAA AGAATAAAGT
TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG TCTAAGATGA AAGGAGAACA CTGGT
TATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCCTTTGG
GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCC
CGTC TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG C
TACTTGGGA GGATGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGAT
CGC ACCAGTGCAC TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AA
AAAAGATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCA
TT TTTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAA
TACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA AATCATTAT
T AAATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA GCTAAGCTAA ACTT
CACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATTAGTC
ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAG
AAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC TTGGGCAAGA GAAAAGTCCA CAGTGATAAG
CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGC
TGAG CAAATTCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT A
GAGAAAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAA
AAG CAAGCTAAGA AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AG
TATAAGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATA
AT TACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT AGA
TTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT ATTTAATTG
T AGGGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT CCAAATTTGA CAGC
AGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT
AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA TACAGACTCT TAACCCTGGT TTACC
AGGAC CTCTAGGAGT GGATCCAATC TATATCTTTA CAGTTGTATA GTATATGATA TCTCTTTTAT
TTCACTCAAT TTATATTTTC ATCATTGACT ACATATTTCT TATACACAAC ACACAATTTA TGAATT
TTTT CTCAAGATCA TTCTGAGAGT TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG G
CAGACACAG AGCACAATGC TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATT
TCA ACTTCAATGT CATCTTCTCC ATGAAGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TT
TCTTGCTC CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGA
CC TCCTTATGTA TTCTCAATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT TCT
TATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCA
A TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC AGCTCTTTAT CAAA
CAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA
TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC ACCAGCCATC TTTTGTCAAT AATTG
ATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATTTGACC AGTCAGTCCT CACTCTTATT
TACTTGCTAT GTAAACTTGA GAAAGCTTTT TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAAT
GAGA AATTTGGAAC AAAAGATTCC TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT A
TTTAGGATT TTTGGTAATC ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTAT
TTG GTGGACATAT TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GT
GGCTCACG CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATC
GA GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGC
GTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGG
G AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGAC
TGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA
TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG GGTTTTTTTC CTAAAAATTG TCTTA
GAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC
GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTA
GTCC CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC-3' (フラグメント番号 )
(配列番号2504) ヒトヒスチジンデカルボキシラーゼ核酸およびアンチセンスオリゴヌクレオチ ドフラグメント 5'-TCT CCC TTG GGC TCT GGC TCC TTC TC TCT CTC TCC CTC TCT CTC TGT CGC CT
C CGC CCT GGC TGC TGG GGT GGT GGT GC TTT TGT TCT TCC TTG CTG CC GCC CCG
CTG CTT GTC T TC CTC G CTC TGT CCC TCT CTC TCT GTB CTC CTC BGG CTC CBT C
BT CTC CCT TGG GC-3'(フラグメント番号1700) (配列番号1711) 5'-GGC TCT GGC (フラグメント番号1701) (配列番号1712) 5'-CCC TTG G (フラグメント番号1702) (配列番号1713) 5'- TT TGT TCT TCC (フラグメント番号1703) (配列番号1714) 5'- TCT CCC TTG GGC TCT GGC TCC TTC TC-3' (フラグメント番号1024) (配列番
号1034) 5'- TCT CTC TCC CTC TCT CTC TGT -3' (フラグメント番号1025) (配列番号1035
) 5'- CGC CTC CGC CCT GGC TGC TGG GGT GGT GGT GC-3' (フラグメント番号1026)
(配列番号1036) 5'- TTT TGT TCT TCC TTG CTG CC-3' (フラグメント番号1027) (配列番号1037)
5'- GCC CCG CTG CTT GTC T TC CTC G-3' (フラグメント番号1028) (配列番号10
38) 5'-CTC TGT CCC TCT CTC TCT GTB CTC CTC BGG CTC CBT CBT CTC CCT TGG GC (
フラグメント番号1029)(配列番号1039) ヒトベータトリプターゼ核酸およびアンチセンスオリゴヌクレオチドフラグメ ント 5'-CTT GCT CCT GGG GGC CTC CTG GTC CCT CCG GGT GTT CCC GGC GGG CCT GGC C
TG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB G
CB GBT TCB GCB TCC TGG-3' (フラグメント番号1704) (配列番号1715) 5'- GCT CCT GGG GGC CT-3' (フラグメント番号1705) (配列番号1716) 5'-CGT BGG CGC-3' (フラグメント番号1706) (配列番号1717) 5'-T GGC CTG GGG-3' (フラグメント番号1707) (配列番号1718) 5'-CTT GCT CCT GGG GGC CTC CTG-3' (フラグメント番号1030) (配列番号1040)
5'-GTC CCT CCG GGT GTT CCC GGC-3' (フラグメント番号1031) (配列番号1041)
5'-GGG CCT GGC CTG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB G
CG CCB GCB GCB GCB GBT TCB GCB TCC TGG-3' (フラグメント番号1032) (配列番
号1042) ヒトトリプターゼ-I核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-CTT GCT CCT GGG GGC CTC CTG GTC CCT CTG GCT G TT CCC GGC CCT GGB CTG
GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB
GGC TCB GCB TCC TGG CCB CGG BBT TCC-3' (フラグメント番号1708) (配列番号1
719) 5'-CT CCT GGG GGC CTC CTG-3' (フラグメント番号1709) (配列番号1720) 5'-B TCC TGG CCB CGG BBT TCC -3' (フラグメント番号1710) (配列番号1721) 5'-GTC CCT C-3' (フラグメント番号1711) (配列番号1722) 5'-CTT GCT CCT GGG GGC CTC CTG-3' (フラグメント番号1033) (配列番号1043)
5'-GTC CCT CTG GCT G TT CCC GGC-3' (フラグメント番号1034) (配列番号1044)
5'-CCT GGB CTG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG C
CB GCB GCB GCB GGC TCB GCB TCC TGG CCB CGG BBT TCC -3' (フラグメント番号
1035) (配列番号1045) ヒトプロスタグランジンDシンターゼ核酸およびアンチセンスオリゴヌクレオ
チドフラグメント 5'-GGT GTG CGG GGC CTG GTG CC CCT GGG CCT CGG GTG CTG CCT GT GCG CTG CCT
TCT TCT CCT GG GTC CTC GCC GGG GCC CTT GCT GCC CTG GCT GT GCC CTG GGG G
TC TGG GTT CGG CTG T CCC CBG CBG GBC CBG TCC CBT CCB CBG CGT GTG BTG BGT
BGC CBT TCT CCT GCB GCC GBG-3'(フラグメント番号1712)(配列番号1723) 5'-T TCT CCT GCB GCC GBG -3' (フラグメント番号1713) (配列番号1724) 5'-CTT GCT GCC CTG GCT GT-3' (フラグメント番号1714) (配列番号1725) 5'- TCT TCT CCT GG-3' (フラグメント番号1715) (配列番号1726) 5'-GGT GTG CGG GGC CTG GTG CC-3' (フラグメント番号1036) (配列番号1046) 5'-CCT GGG CCT CGG GTG CTG CCT GT-3' (フラグメント番号1037) (配列番号104
7) 5'-GCG CTG CCT TCT TCT CCT GG-3' (フラグメント番号1038) (配列番号1048) 5'-GTC CTC GCC GGG GCC CTT GCT GCC CTG GCT GT-3' (フラグメント番号1039)
(配列番号1049) 5'-GCC CTG GGG GTC TGG GTT CGG CTG T-3' (フラグメント番号1040) (配列番号
1050) 5'-CCC CBG CBG GBC CBG TCC CBT CCB CBG CGT GTG BTG BGT BGC CBT TCT CCT G
CB GCC GBG -3' (フラグメント番号1041) (配列番号1051) ヒトシクロオキシゲナーゼ-2核酸およびアンチセンスオリゴヌクレオチドフラ グメント 5'-GGG CGC GGG CGB GCB TCG C TTT GGG CTT TTC TCC TTT GGT T TGB GCG CCB G
GB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG-3' (
フラグメント番号1716) (配列番号1729) 5'-G GCB GGG -3' (フラグメント番号1717) (配列番号1730) 5'-TCC TTT GGT T-3' (フラグメント番号1718) (配列番号1731) 5'- GGG CGC GGG CGB GCB TCG C-3' (フラグメント番号1042) (配列番号1052) 5'- TTT GGG CTT TTC TCC TTT GGT T-3' (フラグメント番号1043) (配列番号105
3) 5'-TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG C
GG GCB GGG -3' (フラグメント番号1044) (配列番号1054) ヒト好酸球カチオニックタンパク質核酸およびアンチセンスオリゴヌクレオチ ドフラグメント 5'-CCT CCT TCC TGG TCT GTC TGC CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG B
BC CBT GTT TCC CBG TCT CTG BGC TGT GGC-3' (フラグメント番号1719) (配列番
号1732) 5'-TTC TCC TTT GGT T-3' (フラグメント番号1720) (配列番号1733) 5'-T TTC TCC TTT GGT T-3' (フラグメント番号1721) (配列番号1734) 5'- GGG CGC GGG CGB GCB TCG C-3' (フラグメント番号1042) (配列番号1052) 5'- TTT GGG CTT TTC TCC TTT GGT T-3' (フラグメント番号1043) (配列番号105
3) 5'-TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG C
GG GCB GGG -3' (フラグメント番号1044) (配列番号1054) ヒト好酸球由来ニューロトキシン(Eosinophil Derived Neurotoxin)核酸およ
びアンチセンスオリゴヌクレオチドフラグメント 5'-GCC CTG CTG CTC TTT CTG CT TCC CTT GGT GGG TTG GGC C GCT GGT TGT TCT
GGG GTT C TTG CTG CCC CTT CTG TCC C TGT TTG CTG GTG TCT GCG C 5'- CCC CB
B CBG BBG BBG CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC TG
T-3' (フラグメント番号1722) (配列番号1735) 5'-TTC CTG T-3' (フラグメント番号1723) (配列番号1736) 5'-CTC TTT CTG CT-3' (フラグメント番号1724) (配列番号1737) 5'-CCC CTT CTG TCC C-3' (フラグメント番号1725) (配列番号1738) 5'- GCC CTG CTG CTC TTT CTG CT-3' (フラグメント番号1047) (配列番号1055)
5'- TCC CTT GGT GGG TTG GGC C-3' (フラグメント番号1048) (配列番号1056)
5'- GCT GGT TGT TCT GGG GTT C-3' (フラグメント番号1049) (配列番号1058)
5'- TTG CTG CCC CTT CTG TCC C-3' (フラグメント番号1050) (配列番号1057)
5'- TGT TTG CTG GTG TCT GCG C -3' (フラグメント番号1051) (配列番号1059)
5'- CCC CBB CBG BBG BBG CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT
GTT TCC TGT-3' (フラグメント番号1052) (配列番号1060) ヒト好酸球ペルオキシダーゼ核酸およびアンチセンスオリゴヌクレオチドフラ グメント 5'-GCG CTC GGC CTG GTC CCG G GGG TCT CCT CTT GTT GTT GC TTG CGC CTC CTG
CTG GGG GT CC CTC TGT TCT TGT TTT GGG GGC GGG CCC GGC CGT TGT CTT G GTT
TGG GGG TTT CCG TTG GGG TTC TCC TGG CCC GGG CCT TGC CC GGC CGT GGT CCC G
GC TTC GTTCCT GTC TCC GTC TCG GCT CTT CTG GGG CCT TGC GCT GTC TTT GGT G
5'-GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC GCT GCB GCG CTC GGC CTG GTC C
CG GBG BGC CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCT
GCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG G
TAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTTT CAGTCTCAAA ACTCCCA
TGA AAACCAGAGA GAAGTTTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG CCCAGAGCTG CC
CTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC AGAGAAGAGC TGGAGGAA
GT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTG
GATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC AGAGATGCAT CTGCTCCCAG CCCTGGCAG
G GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTA
GACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCTTGGAGGG GGTCTTGTGG
CTTGCTGAAC CCTGAGTCCC CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCC
TGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG
TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT TAATACCTTG TGGGGTCAGG GAG
CCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTT
C CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCA
TTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGTTGACT
GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTTCCCAT CAAGGTACCT ACCCTCAGCC AATCT
CCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG
CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG CACTGTCTCC TC
TTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC TTTCTTCC
GC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCC
TTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACC
A ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTT
CGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC
AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGA
AGCAA TGGTGGGATG TGGTGAAGGT ACATGGTTTG GGACCTCAGT ATTAGGCACA CCATAAGCAT
GGATCTGTGC AC TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCC
CATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGA
G CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCT
CTTTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA
CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCC
AGCAT CCCCC CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGA
CAATA AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA
ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAA
GGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG G
CCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGG
ACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GC
TGGCGGAT CGTGTATGAA GGTGACCAGG TTTTCCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCAT
GC CCTCCCCTAG GTGG TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTAC
T AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCT
TCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT
CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCC
GGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA
AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTTTGCTCG GGCCAG
GCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC CGACTGCCTG GTAGGTTCTG GTGGCAGAAA C
GAGGTGTTT TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAATTTCCTT GTCTCGAATT ATATGTG
ACA ATACCGGTAT CACCACGGTT TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TT
GTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGG
TA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC ACATCCTTCC CTGGATGGAT GGC
TGAGTCC TCTTAGGTCT CTAAGCAGAG AAAACAGAAC TTGTCACTAG GTACTCTTTC CAAGTGGCT
T CCCAATGTGC TAGTTTCTGG GCTGACAGTC AATTCCAGGC CCTAGGACTT TGGGGGGAAA TTAG
GAGCAT CCAACTA GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GG
CAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACA
AT TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTG
TCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT ATGCATGTG
G CTTTGGGGCT GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTC ATTGTCACTG ATGT
GCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA
GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACCCTT GCTAG
GGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC
TTCGGCTGGA CCCCCAGCAG GAGGCGCAAT GGCTTCCTTC TCCCTCTTGT CCGGGCTGTC TCCAAC
CAGA TTGTGCGCTT CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC A
GTGGGGCCA GTTCATTGAC CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCAC
TGC AGGCGTTGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC AC
CCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCATC CCTTTCTTCC GCTCGGCACC CTCATGCC
CC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC ATG
GTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTG
G CCATCAACCA GCGCTTTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC AACCTGCACG ATGA
CCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG GCAGGTGACA CCCGATCAAC
GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCTTTATG CGAGAGCACA ACCGGCTGGC CACCG
AGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG
GGGGCCATGG TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCC
AGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT T
CACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTA
CCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CG
TGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTC
AG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTG
GACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT GCTTGGAGG
C GCTTCTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGA
CTTGGC AAGGAAGTTC CTGAATTTGT ATGGAACACC TGACAACATT GACATCTGGA TTGGGGCCAT
CGCTGAGCCT CTTTTGCCGG GGGCTCGAGT GGGGCCTCTT CTGGCTTGTC TGTTCGAGAA CCAGT
TCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT GTTTTCACCA AAGACAGCGC
AAGGCCCTGA GCAGAATTTC CTTGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG GTTTCA
AGGG ACATCTTCAG AGCCAACATC TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT T
GAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTTTTG
GAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GA
CGCTTCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATC
AG CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC AAA
GGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTTTACAGC
A CTTTCTACTG TTTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTA
GCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TTCTACCAAT
AAAGCACTGC CGGAATTC-3' (フラグメント番号1726) (配列番号3008) 5'-CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGG
GCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGG
A AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTTT CAGTCTCAAA ACTCCCATGA AAAC
CAGAGA GAAGTTTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG CCCAGAGCTG CCCTCCCCCA
CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAG
GTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA
CTCACTTCCC AGCTGGTGAA GCCTCGCTGC AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCT
GGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG C
AAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCTTGGAGGG GGTCTTGTGG CTTGCTG
AAC CCTGAGTCCC CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GA
CTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTG
GG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT-3' (フラグメント番号 )(配列番
号2483) 5'-TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC CGG
GCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTC
A TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG CCAG
AGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTTCCCAT
CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG TGCTG
GGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG
ACAGAGACAC AAG-3' (フラグメント番号 )(配列番号2484) 5'-CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACT
GCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCA
A CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGG
CTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTTCAAGA CAACGGCCGG
GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCAT
CCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGAAACA GCCATCCCTG
GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGGTTTG GGACCTCAGT ATTAGG
CACA CCATAAGCAT GGATCTGTGC AC-3' (フラグメント番号 )(配列番号2485) 5'-TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC AGC
CCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTT
T TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTTTAT GCGA
GAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC
AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC
-3' (フラグメント番号 )(配列番号2486) 5'-CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGACAATA AAG
AATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTC
C TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGG
CCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT
TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAG
TACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT
CGTGTATGAA GGTGACCAGG TTTTCCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCC
CTAG GTGG-3' (フラグメント番号 )(配列番号2487) 5'-TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG ACT
GGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTC
C AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGG
CCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC
GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGC
CTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT
TCTGGGAAGA CCCTGGTACC-3' (フラグメント番号 )(配列番号2488) 5'-CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG GCC
CTGAGCA GAATTTCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT TCAAGGGAC
A TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCT
ATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG
GTTAAGCCTC ACATCCTTCC CTGGATGGAT GGCTGAGTCC TCTTAGGTCT CTAAGCAGAG AAAAC
AGAAC TTGTCACTAG GTACTCTTTC CAAGTGGCTT CCCAATGTGC TAGTTTCTGG GCTGACAGTC
AATTCCAGGC CCTAGGACTT TGGGGGGAAA TTAGGAGCAT CCAACTA-3' (フラグメント番号 )(配列番号2489) 5'-GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACC
TCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACAAT TGGACCCAG
A AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAA
ACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT ATGCATGTGG CTTTGGGGCT
GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTC ATTGTCACTG ATGTGCTAAC AGAAC
CACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC
GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAAC
CAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC TTCGGCTGGA C
CCCCAGCAG GAGGCGCAAT GGCTTCCTTC TCCCTCTTGT CCGGGCTGTC TCCAACCAGA TTGTGCG
CTT CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GT
TCATTGAC CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGTTG
AC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC CCC
CGCATCA AGAACCAGCG TGACTGCATC CCTTTCTTCC GCTCGGCACC CTCATGCCCC CAAAACAAG
A ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC ATGGTGTATG GCAG
TGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA
GCGCTTTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC AACCTGCACG ATGACCCCTG TCTCC
TCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC
AAACTGGCAG CCATGCACAC CCTCTTTATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGC
CTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG T
CCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCT
GGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CT
TCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCG
CA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGG
GGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATG
T TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGC
TCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT GCTTGGAGGC GCTTCTGTGG
GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGACTTGGC AAGGA
AGTTC CTGAATTTGT ATGGAACACC TGACAACATT GACATCTGGA TTGGGGCCAT CGCTGAGCCT
CTTTTGCCGG GGGCTCGAGT GGGGCCTCTT CTGGCTTGTC TGTTCGAGAA CCAGTTCAGA AGAGCC
GAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT GTTTTCACCA AAGACAGCGC AAGGCCCTGA G
CAGAATTTC CTTGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG GTTTCAAGGG ACATCTT
CAG AGCCAACATC TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AG
CCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTTTTGGAG ACAAGGGG
AA GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG CTG
GCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACC
T TCCGCCTTGG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC AAAGGCTTGG GAGC
CAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTTTACAGCA CTTTCTACTG
TTTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACA
CCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TTCTACCAAT AAAGCACTGC
CGGAATTC-3' (フラグメント番号 )(配列番号2490) 5'-TC GGC CTG GTC CCG G-3' (フラグメント番号1727) (配列番号1740) 5'-TGG GGG TTT CCG TTG-3' (フラグメント番号1728) (配列番号1741) 5'-TG GTC CCG GBG BGC -3' (フラグメント番号1729) (配列番号1742) 5'-GCG CTC GGC CTG GTC CCG G-3' (フラグメント番号1053) (配列番号1061) 5'-GGG TCT CCT CTT GTT GTT GC-3' (フラグメント番号1054) (配列番号1062)
5'- TTG CGC CTC CTG CTG GGG GT CC-3' (フラグメント番号1055) (配列番号106
3) 5'-CTC TGT TCT TGT TTT GGG GGC-3' (フラグメント番号1056) (配列番号1064)
5'-GGG CCC GGC CGT TGT CTT G-3' (フラグメント番号1057) (配列番号1065) 5'-GTT TGG GGG TTT CCG TTG-3' (フラグメント番号1058) (配列番号1066) 5'-GGG TTC TCC TGG CCC GGG CCT TGC CC-3' (フラグメント番号1059)(配列番号
1067) 5'-GGC CGT GGT CCC GGC TTC GTT GC-3' (フラグメント番号1060) (配列番号106
8) 5'-CCT GTC TCC GTC TCG GCT CTT CTG-3' (フラグメント番号1061) (配列番号10
69) 5'-GGG CCT TGC GCT GTC TTT GGT G-3' (フラグメント番号1062) (配列番号1070
) 5'-GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC GCT GCB GCG CTC GGC CTG GTC C
CG GBG BGC -3' (フラグメント番号1063) (配列番号1071) ヒト細胞間接着分子-1(ICAM-1)核酸およびアンチセンスオリゴヌクレオチドフ ラグメント 5'-GCG CGG GCC GGG GGC TGC TGG G GGT TGG CCC GGG GTG CCC C GCC GCT GGG T
GC CCT CGT CCT CTG CGG TC GTG TCT CCT GGC TCT GGT TCC CC GCT GCG CCC GTT
GTC CTC TGG GGT GGC CTT C GCT CCC GGG TCT GGT TCT TGT GT TGG GGG TCC CT
T TTT GGG CCT GTT GT GGC GTG GCT TGT GTG TTC GGT TTC TGC CCT GTC CTC CGG
CGT CCC CGG BGC CTC CCC GGG GCB GGB TGB CTT TTG BGG GGG BCB CBG BTG TCT
GGG CBT TGC CBG GTC CTG GGB BCB GBG CCC CGB GCB GGB CCB GGB GTG CGG GCB
GCG CGG GCC GGG GGC TGC TGG GBG CCB TBG CGB GGC TGB G-3' (フラグメント
番号1730) (配列番号1743) 5'-GGG GGC TGC TGG G-3' (フラグメント番号1731) (配列番号1744) 5'-T GTC CTC CGG CGT CCC-3' (フラグメント番号1732) (配列番号1745) 5'-G CCB TBG CGB GGC TGB G-3' (フラグメント番号1733) (配列番号1746) 5'-CTC TGG GGT GGC CTT C-3' (フラグメント番号1734) (配列番号1747) 5'-GCG CGG GCC GGG GGC TGC TGG G-3' (フラグメント番号1064) (配列番号1072
) 5'-GGT TGG CCC GGG GTG CCC C-3' (フラグメント番号1065) (配列番号1073) 5'-GCC GCT GGG TGC CCT CGT CCT CTG CGG TC-3' (フラグメント番号1066) (配
列番号1074) 5'-GTG TCT CCT GGC TCT GGT TCC CC-3' (フラグメント番号1067) (配列番号107
5) 5'-GCT GCG CCC GTT GTC CTC TGG GGT GGC CTT C-3' (フラグメント番号1068) (
配列番号1076) 5'-GCT CCC GGG TCT GGT TCT TGT GT-3' (フラグメント番号1069) (配列番号107
7) 5'-TGG GGG TCC CTT TTT GGG CCT GTT GT-3' (フラグメント番号1070) (配列番
号1078) 5'-GGC GTG GCT TGT GTG TTC GGT TTC-3' (フラグメント番号1071) (配列番号10
79) 5'-TGC CCT GTC CTC CGG CGT CCC-3' (フラグメント番号1072) (配列番号1080)
5'- CGG BGC CTC CCC GGG GCB GGB TGB CTT TTG BGG GGG BCB CBG BTG TCT GGG
CBT TGC CBG GTC CTG GGB BCB GBG CCC CGB GCB GGB CCB GGB GTG CGG GCB GCG
CGG GCC GGG GGC TGC TGG GBG CCB TBG CGB GGC TGB G-3' (フラグメント番
号1073) (配列番号1081) ヒト血管細胞接着分子1(VCAM-1)核酸およびオリゴヌクレオチドフラグメント
5'-CCT CTT TTC TGT TTT TCC C CTC TGC CTT TGT TTG GGT TCG CTT CCT TTC TGC
TTC TTC C CTG TGT CTC CTG TCT CCG CTT TTT TCT TC GTC TTT GTT GTT TTC TC
T TCC TTG CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GBT TTT BBBB GCT T
GB GBB GCT GCB BBC BTT BTC CBB BGT BTB TTT GBG GCT CCB BGG BTC BCG BCC B
TC TTC CCB GGC BTT TTB BGT TGC TGT CGT-3'(フラグメント番号1735)(配列番号
1748) 5'-C TGT CGT-3' (フラグメント番号1736) (配列番号1749) 5'-TGC TTC TTC C-3' (フラグメント番号1737) (配列番号1750) HSVCAM1AS1: 5'-CCT CTT TTC TGT TTT TCC C-3' (フラグメント番号1074) (配列
番号1082) HSVCAM1AS2: 5'-CTC TGC CTT TGT TTG GGT TCG-3' (フラグメント番号1075) (配
列番号1083) HSVCAM1AS3: 5'-CTT CCT TTC TGC TTC TTC C-3' (フラグメント番号1076) (配列
番号1084) HSVCAM1AS4: 5'-CTG TGT CTC CTG TCT CCG CTT TTT TCT TC-3' (フラグメント番
号1077) (配列番号1085) HSVCAM1AS5: 5'-GTC TTT GTT GTT TTC TCT TCC TTG-3' (フラグメント番号1078)
(配列番号1086) CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GBT TTT BBBB GCT TGB GBB GCT
GCB BBC BTT BTC CBB BGT BTB TTT GBG GCT CCB BGG BTC BCG BCC BTC TTC CCB
GGC BTT TTB BGT TGC TGT CGT(フラグメント番号1079)(配列番号1087) ヒト内皮白血球(Endothelial Leukocyte)接着分子(ELAM-1)核酸およびアンチ
センスオリゴヌクレオチドフラグメント 5'-BBG TGB GBG CTG BGB GBB BCT GTG BBG CBB TCB TGB CTT CBB GBG TTC TTT T
CB CCC GTT CTT GGC TTC TTC TGT C CGT TGG CTT CTC GTT GTC CC TGT GGG CTT
CTC GTT GTC CC CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G GTT CTT
GGC TTC TTC TGT CCG T TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC
CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G CCTGAGACAG AGGCAGCAGT
GATACCCACC TGAGAGATCC TGTGTTTGAA CAACTGCTTC CCAAAACGGA AAGTATTTCA AGCCT
AAACC TTTGGGTGAA AAGAACTCTT GAAGTCATGA TTGCTTCACA GTTTCTCTCA GCTCTCACTT
TGGTGCTTCT CATTAAAGAG AGTGGAGCCT GGTCTTACAA CACCTCCACG GAAGCTATGA CTTATG
ATGA GGCCAGTGCT TATTGTCAGC AAAGGTACAC ACACCTGGTT GCAATTCAAA ACAAAGAAGA G
ATTGAGTAC CTAAACTCCA TATTGAGCTA TTCACCAAGT TATTACTGGA TTGGAATCAG AAAAGTC
AAC AATGTGTGGG TCTGGGTAGG AACCCAGAAA CCTCTGACAG AAGAAGCCAA GAACTGGGCT CC
AGGTGAAC CCAACAATAG GCAAAAAGAT GAGGACTGCG TGGAGATCTA CATCAAGAGA GAAAAAGA
TG TGGGCATGTG GAATGATGAG AGGTGCAGCA AGAAGAAGCT TGCCCTATGC TACACAGCTG CCT
GTACCAA TACATCCTGC AGTGGCCACG GTGAATGTGT AGAGACCATC AATAATTACA CTTGCAAGT
G TGACCCTGGC TTCAGTGGAC TCAAGTGTGA GCAAATTGTG AACTGTACAG CCCTGGAATC CCCT
GAGCAT GGAAGCCTGG TTTGCAGTCA CCCACTGGGA AACTTCAGCT ACAATTCTTC CTGCTCTATC
AGCTGTGATA GGGGTTACCT GCCAAGCAGC ATGGAGACCA TGCAGTGTAT GTCCTCTGGA GAATG
GAGTG CTCCTATTCC AGCCTGCAAT GTGGTTGAGT GTGATGCTGT GACAAATCCA GCCAATGGGT
TCGTGGAATG TTTCCAAAAC CCTGGAAGCT TCCCATGGAA CACAACCTGT ACATTTGACT GTGAAG
AAGG ATTTGAACTA ATGGGAGCCC AGAGCCTTCA GTGTACCTCA TCTGGGAATT GGGACAACGA G
AAGCCAACG TGTAAAGCTG TGACATGCAG GGCCGTCCGC CAGCCTCAGA ATGGCTCTGT GAGGTGC
AGC CATTCCCCTG CTGGAGAGTT CACCTTCAAA TCATCCTGCA ACTTCACCTG TGAGGAAGGC TT
CATGTTGC AGGGACCAGC CCAGGTTGAA TGCACCACTC AAGGGCAGTG GACACAGCAA ATCCCAGT
TT GTGAAGCTTT CCAGTGCACA GCCTTGTCCA ACCCCGAGCG AGGCTACATG AATTGTCTTC CTA
GTGCTTC TGGCAGTTTC CGTTATGGGT CCAGCTGTGA GTTCTCCTGT GAGCAGGGTT TTGTGTTGA
A GGGATCCAAA AGGCTCCAAT GTGGCCCCAC AGGGGAGTGG GACAACGAGA AGCCCACATG TGAA
GCTGTG AGATGCGATG CTGTCCACCA GCCCCCGAAG GGTTTGGTGA GGTGTGCTCA TTCCCCTATT
GGAGAATTCA CCTACAAGTC CTCTTGTGCC TTCAGCTGTG AGGAGGGATT TGAATTATAT GGATC
AACTC AACTTGAGTG CACATCTCAG GGACAATGGA CAGAAGAGGT TCCTTCCTGC CAAGTGGTAA
AATGTTCAAG CCTGGCAGTT CCGGGAAAGA TCAACATGAG CTGCAGTGGG GAGCCCGTGT TTGGCA
CTGT GTGCAAGTTC GCCTGTCCTG AAGGATGGAC GCTCAATGGC TCTGCAGCTC GGACATGTGG A
GCCACAGGA CACTGGTCTG GCCTGCTACC TACCTGTGAA GCTCCCACTG AGTCCAACAT TCCCTTG
GTA GCTGGACTTT CTGCTGCTGG ACTCTCCCTC CTGACATTAG CACCATTTCT CCTCTGGCTT CG
GAAATGCT TACGGAAAGC AAAGAAATTT GTTCCTGCCA GCAGCTGCCA AAGCCTTGAA TCAGACGG
AA GCTACCAAAA GCCTTCTTAC ATCCTTTAAG TTCAAAAGAA TCAGAAACAG GTGCATCTGG GGA
ACTAGAG GGATACACTG AAGTTAACAG AGACAGATAA CTCTCCTCGG GTCTCTGGCC CTTCTTGCC
T ACTATGCCAG ATGCCTTTAT GGCTGAAACC GCAACACCCA TCACCACTTC AATAGATCAA AGTC
CAGCAG GCAAGGACGG CCTTCAACTG AAAAGACTCA GTGTTCCCTT TCCTACTCTC AGGATCAAGA
AAGTGTTGGC TAATGAAGGG AAAGGATATT TTCTTCCAAG CAAAGGTGAA GAGACCAAGA CTCTG
AAATC TCAGAATTCC TTTTCTAACT CTCCCTTGCT CGCTGTAAAA TCTTGGCACA GAAACACAAT
ATTTTGTGGC TTTCTTTCTT TTGCCCTTCA CAGTGTTTCG ACAGCTGATT ACACAGTTGC TGTCAT
AAGA ATGAATAATA ATTATCCAGA GTTTAGAGGA AAAAAATGAC TAAAAATATT ATAACTTAAA A
AAATGACAG ATGTTGAATG CCCACAGGCA AATGCATGGA GGGTTGTTAA TGGTGCAAAT CCTACTG
AAT GCTCTGTGCG AGGGTTACTA TGCACAATTT AATCACTTTC ATCCCTATGG GATTCAGTGC TT
CTTAAAGA GTTCTTAAGG ATTGTGATAT TTTTACTTGC ATTGAATATA TTATAATCTT CCATACTT
CT TCATTCAATA CAAGTGTGGT AGGGACTTAA AAAACTTGTA AATGCTGTCA ACTATGATAT GGT
AAAAGTT ACTTATTCTA GATTACCCCC TCATTGTTTA TTAACAAATT ATGTTACATC TGTTTTAAA
T TTATTTCAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GATGTTAACC AGAATAAAGT TCTG
AGTGTT TTTACTACAG TTGTTTTTTG AAAACATGGT AGAATTGGAG AGTAAAAACT GAATGGAAGG
TTTGTATATT GTCAGATATT TTTTCAGAAA TATGTGGTTT CCACGATGAA AAACTTCCAT GAGGC
CAAAC GTTTTGAACT AATAAAAGCA TAAATGCAAA CACACAAAGG TATAATTTTA TGAATGTCTT
TGTTGGAAAA GAATACAGAA AGATGGATGT GCTTTGCATT CCTACAAAGA TGTTTGTCAG ATGTGA
TATG TAAACATAAT TCTTGTATAT TATGGAAGAT TTTAAATTCA CAATAGAAAC TCACCATGTA A
AAGAGTCAT CTGGTAGATT TTTAACGAAT GAAGATGTCT AATAGTTATT CCCTATTTGT TTTCTTC
TGT ATGTTAGGGT GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCATTTAT GTTTATTTAT AA
GCAGATTT AACAATTCCA AAGGAATCTC CAGTTTTCAG TTGATCACTG GCAATGAAAA ATTCTCAG
TC AGTAATTGCC AAAGCTGCTC TAGCCTTGAG GAGTGTGAGA ATCAAAACTC TCCTACACTT CCA
TTAACTT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTGGCT GAACACTGGC AACGACAAA
G CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AGAGGTTCTT TTAAAGGGGC AGAA
AAACTC TGGGAAATAA GAGAGAACAA CTACTGTGAT CAGGCTATGT ATGGAATACA GTGTTATTTT
CTTTGAAATT GTTTAAGTGT TGTAAATATT TATGTAAACT GCATTAGAAA TTAGCTGTGT GAAAT
ACCAG TGTGGTTTGT GTTTGAGTTT TATTGAGAAT TTTAAATTAT AACTTAAAAT ATTTTATAAT
TTTTAAAGTA TATATTTATT TAAGCTTATG TCAGACCTAT TTGACATAAC ACTATAAAGG TTGACA
ATAA ATGTGCTTAT GTTT GATCAAAATT TTTACCTATT ATGCATTTGA TATATAAATA AGTATAT
AAA TGCACACACA GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CA
TAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAG
TT CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG GGG
AGGGGAC AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGAT
G CTGGCTACAG GATGTGTTGG TTGTAAAAAT GCATTTTTTT ATATCTAGCT TTTTCCATGT GTAT
ATTATA CTTCAAAGAA GTTCAGTTAA TAATTTCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA
GCAAGCCTCT GGCTTAATCT TGTTTTACCT TAAGCCATCA GTCATTTACA AGTAGGAAAA TTCAC
AGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTTTCCAA
AGCCCGTTTA TTTCTTGATT CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TTTTTCATGT ATCTTA
CAAG AAGACAGCAT GTGCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA A
AGAACCACA TTTTTCTTGT AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGAC
CAA TAGGTGGGAT TAAAGATACA GTAGAAAGTA TTTAAAACTT GCCAGGGGGC AATAGTCTGA AA
ATAAGTAA ATTGGTGCTA TAGAATGGAA GTTACAGGCT TCTTTCTTTT TTCCCACAAG ATCTGCTC
CT TGAGCCCCTA GAGACTTTTC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG CCC
TGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAA
C CTCTGACTGC TGCGCATAAT ACATTTCACT CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAG
AGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATCTTTGACA AAATCCACAA AAACAAGCAA
TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTG
AACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT
AAAACCAAAC ACTATAAAAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGG
CAAA GACTTCATGA CAAGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA A
TGAAACTCT TTAGTTGTAC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAA
CAA CCTACAGAAT GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TC
TATAAGGA ATTTAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATG
AA CAGATGCTTT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC ATC
ACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGAC
T ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGTT TATG
CACTGC TAGTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGATT CCTCAAAGAA
TGTAAAACCG AACTGCCTTT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAA
ATTGT TTTACCGTAA AGGCGCATGC ATGCATATGT TCATTACAGC ACTATTTACG ATAGCAAAGA
CATGGAATCG TCTAAATGCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATAC
ATCA CAGAATAGTA TGCAGCCATA AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA T
GTAGTTGGA GGCCATTATC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTC
ATT TATAAGTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GA
CCTACTTG AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTA
TT ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG AAA
ACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTTGTGGT
A TAAATCTGAG CATTCATATT AAAATAAAAT ATTTACCTCA TTAGAGTAAT TAACATTTAT TAAG
CAAAGA GCCAAGTACC TTACACACAT GATGTTTAAT CTCACAATGA TCTTTAATCT CATAACAACC
GTCCATTGTA TGTACATATG TGGAAATTGA GCCTTGGAGA GATTAAATGC ATGGGGCATG CCATT
TGACT AGAAACTGGA AGCATCAGGA TTTAAACTCA GTTCTGAATG GTTTTGTAGG CTTTGTTTTT
TCCACATTAT AGCATGGCCT GCCATGAAGA ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAA
GTGA AGCAAATATT TATTTAAATA TTCAAGATAT GCTGTTAAAT TTTTACTCAA AAATTTGAGT A
CAGTATGGA TCTTCTGAAG CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTTTAT GGAGTAG
TTC TCAATTTTTA TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TT
TTCCTCAT TTGGACATCA GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTTTTA AAATAAAA
AC CTTGTTTTTA TATCAAGTGG GGACATTTTT TCCAAATGAA AACCGTGTAT TCATTTTATA TGA
TAAAATC AATGTTATTA TTTTTAAAAT TTTGATTTAA AAATCATTAA AAATAAATTT TCAGATATT
A CCTGAAATTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA GACACACACA CATA
TATACA TATATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA GTTTTTAATA AAAACTAGGA
GATTAATGCC CTTTGAATGA AAATAAATAC AATGTGTATG CTTTAACATC TTGCCTTTAC TTTAT
AACAT TTATCACAGC AGTCATGAGA TAATGATTTA CATGGTCATT GTTAGTAAGC TAATAGCTAA
GTGCATGAAC TCTGGAGCTA GCCTCCCTGG ATTTTAATCC CAGATCTGTC ACTGACCAGC TGAGCA
ATAC TAGGTAAATT GCTCTTGTTC CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT C
CACCTCATA GGATTGGTGT GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCT
TCA CATACTGAAC ACAAATATAC GAGCTGTTGT CTTATTGGGC TCATGTTTTT CCTACCACTA AG
CCGCATGC ATGCAAGGAC CATGTTGGTT TTGTTCCACA TTGCATCCCC AACCTGGTAT ACAGTGTG
CA TTCAATAGTT GTTGACTATT ATTACTAGTG GCATTTAACA AATATCTGTT AAATGAGTGA AGA
AATACCC ATTTACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA CTCTGGAGT
C AAACAGGTTT TAAAACCTTA TTCCCTCATC CTCAGTTATT GACGTTTTTT TTTTGGCAGG TGTG
TGTGTG GGACAACTTA TTGAACTTTT CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA
TTCATTCTTG CAATGTATGG ATTTGAGACA ATTGTGTAAG TTTATCAATA AATAGTAGCT ATTTT
TGTAT AAGTATTACA TATAATATCC AGGCCACTGC TTTGCATAAC CCAAAAGGGG CACCATTCAT
GCAGAATACA ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGT
ATAC TTTATAGTTC ATAGATTACA AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT T
GAGGTCCAT AAGAGCAATT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATT
TTA AATCCGCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTTAAATGCC AA
GTTCACCA TTTTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTG
AA TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA TGT
CCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATT TTCTTGGCA
A GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTAGCATACC CTGT
TGTGCA AATGCTGTCT GTGTTTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG
CCCACAAGTT TTCCCAGAAC TTTCTTATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ATAGT
TTGGT ACACAAAAGG GTCAACCTGG GGGATGGCTA GGGTTTGACT CAGTCGTTAC ATTTCAATAG
AGCAGGAAGG GGAAATGGTG GCCTGTAACC TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCT
CTCT CCTGCTCTGA GGAAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC T
AACCAGAGA AGCAGACTCT TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTTTAT TAAAATT
TTT AATAACACTC AAGTATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG AC
TCTTCCTC TGTGGAAGAA TCAGCCAATC ACATTTGTTT ACATCAGTTC CCCTGAAGAA GAAAAATA
CA CTGATGTTGC AGCAAGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG CTA
GGCTAAT TACATATTGG AACTATTTTT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA AGAATTCTG
A AGAAAATATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGA
TACTCG TTCTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTTTGT ATTAGTATGT
TTTTACACTT ATTTGCAAGG CATAAATAGG TTAGGTTTTG ATCTTAATTT AATTCTAACA TGTAT
TGTGC ACAAGCTGTG AGCAGTTTTC AGGAGTTAGG TATCTGGCCA TGACTGATTT TTCAGGAGTT
AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATA
ATCA CACAGAGAGC TGTAGAATTT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT T
GGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAAC
CCC GTCTGTACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CC
AGCTACTT GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGA
GA TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAA
AAAAGTC ATGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCA
G TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCATTT TCATGGCCAA CATTGTCAGT CAGC
ATCATT GAATTACTCC TGATTATAGA GACACAGCTG CAAACGATTC CCCATTAAAT ATGATGTTTC
TTGCAATGTT TGGAAGGTAC TCCTTTTTAG TAAGGGAAAT CCCCTCTTCT GGCTTGCTGA AAGTT
TTTTC TTTCCATTTT AAAAATCGTG AATTCCTTTT TGCAATATTG AGGTGGTTAT ATGGTTTCTC
TTCTCTAATC TGTTAATATG GTGATTTAAT GGTTAGAAAT TTTCTAATGT AAATTCCACT CATATT
GCAG AAATAAACCT AAACTGAGCA TGAGGCTATA TTTTTTATTT GCTTCTATAT TTGGTTGCTA T
ACAGTATTA TGTTTAAGAT TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTATTTTTC CTTCTTG
CCG ATTTTTATCT GGTTTTTAAA TTAAGGATAT TTTAGACTTA TGAAATATTT GGCAAACAAT CC
TTGGCAAG TAATTTTTTG GGGAATTTGT TTTGGCTATT TTGAGTATTA CCCAATATAT TTTAATTA
AG TTATTCTTAA TGTTTTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC TCC
AGATTTT GTCTATTTAT ACCACTTTTC TTTTTTCCTC GATGAGTGTC ATAGATGTTC ATCTATTTT
T TTATCTTCTT TGATCTTCTC TTATTCCTTG TTTCTATTAA CTTCTGAAGT TTATTATTTT CTTT
TTTCCA CTTCCTTATG GTTTATTCTT TCAATTTTTC TCTAACTTCT TAAGTTGGGT GTTTAATTTT
TAGCTTGCTT TGCTTTTTTA GGATAAGCAT TAAAACTACA AATTTTCCTT GTTATTCTTT TGCTG
CACCC CAAATTGTTG ATATTTCTAT TGTCTAATTT CTATTCAATT AGAATACTTT AAAGTTTCTT
TTTGGTTTTT AAAAACTAAC TTTTTAAATT GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGC
ATAT GGCTTTGAAA TATATGTACA TTGTGGAATG GCTAAATTTA GCTTATTAAT GTATGCATTA T
CTCACATAC TTATCATTTT TTGTGGTGAG AGCTATGTGA CTTTTGAACT TATGAGTTAT TTAAATA
TTT TTAAATTATT AAGCATATTG GGATTTTAAG TAATTTACCT TTTTATTATT AACTTATAAC AA
GTAGAACA GTTAACCTGT ATGATTCTAC ATCATTGAAA TTTATTGACA TTTGCTTCAT AGTCTATT
AT ATGGTCTACT TTTGTTCATG TTACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA CAC
ATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT GTTCTAGGT
G CTATTATATG TTGTCATGTT TAATCCTCAC CACAATTGTA TGAGGCAGCC ATAATTAATT CCAC
TTTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATTTGTAAAG AATGAAGCAA
AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATATT TAAGCATTTT AATTCAAGCT TTAAA
ACTGC TAAATAAAAT GTGCTCCAAT TTCTATATTG ACAGACATAC CTTCCTAATG AGCTGGGGTT
CGAATTTAGA AATCTTTGAT GCTTCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTC
CCCA GCCTTCAGTC CACCCACCTT CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC C
CAGCCTCCA AGTCCAAACC CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCAT
CCT CAGGAAAACC TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TG
TGGTCTAT AAGGGAGGCC TCAGAAGACA GGTTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAA
GG GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTG
CCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCAC
A GGTCTTCTGA AATTAATAAT AATAATAACT ATTACCATTA TTATACCAGT AGCTGTCATT TATT
TAGTGC TTATTATTTG CCAGTCACTG TTCTAAATTC TTTACATGTA TTATACAACT GCCATATAAC
TGCCATATGA GGGATGTACC CTCATTGTCA CCATTTTACC GATGAGAAAA CTGGCATAAA ACGTT
TAAGT AACTTGTCCA AGTTACAGAG CTTAGTGAAG CCACAATGTT GCTCAATTTG CTCTCAAACT
TCAAAGGGAT GGGAAGGACA CCTAAGTCAT AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAG
ATGT TATCTAGTCA GCCTCCTCCC ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC T
ATTTTTGCA TGTGAATTGC AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCG
CTG GATATAGGAA CAGTGGTTTT AAATCTCTAG GCTTTAACTT TTCTCAGAAC AAGAAATCCT TT
TTGGTTTT AATCTATATG CACATCTGTA TTTTTCTCAA TTATCGGGTA GTAAAATATA ACTTTTCT
TC TGTAATATTT TTTAACTTTA ATGAGTGTTC CTCATAATAG AAAAGTTTGG AAACCATTGC TAT
GGGTATA TACTTTCTAA AGGGATAGTA ATTTCTCTAG AATATTCATT TAATGCTCCA GAAGTAATT
A GCACAATTGT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTTTA CTCCAAATCC ACAT
GAAACT GATTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATTTT TGGAGACTTC CTGGTACATT
GAGACAGGGT CGGCCAGTCT GCGTTAGGGT CTTGGTCAAA ACTGCATTTC TGAAACTAAA CTCAG
ATTGC TTTCTTTTAA GGGGTCAGAA CTGATTCAAA TCTACATTTT TAAAAGCCTT AGATGTGGGG
CTTTTCCTAT TCCCAGTCTC CGCTATTGGT CTTTGTGAAT CCACAGGCAA TTTGGCCACA TCCTTG
ACTC TCTCTTATAT TAAGAATTAA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA C
TTTCCTACA AGATCTTTGA AAAATGGAAC ATTTGCATAA GTCATATTTA GCCAGAACTG TTGTTTT
ATA TTTTCCTTTC TGAATACTTT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CA
ACTAGTCA GAGACCAAAG CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCAT
CA CGCCTGAATA ATTACATTCA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA ACC
CTCTGAC ACCTTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA GTTTTCCCA
G AAACTAGAGT ACAAACTTTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT CTTTTTCATC CCCA
GGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA TACCTTTGTC TTAGATACTA
GACTCTCCTC CTGGTTTCTA ATTAAACCTG ATCTAGGATC TAATTTTGCC TCTGAATTCT GTTGC
CCTTT GCCAAGTGAT CTCTTCCTCC TCTGAGCCGC AGCATCTCTG AGCTTGCACA CTTAGCATAG
CCATAGCACA CACAGCCTTA GCTTGCAGTT CAGGGTGTTT ACCTTCCCTC CCCTTCCAGA TGCTGG
ATCC CCAGGGATAG GAACTCTGCC CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG T
ACATTTTCA GCAAATGTTT AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCTTTT
TGC TAAACATGCC TGTGTCCTTT GTCATTGAAC AACTATTTTG ATCTATTTTC TTCCTGACAT AG
GGGTCAGT TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGT
GA TTTTGTTGTG AATTGAGAAC TGGCTGCCTA CTTTTGGACT ACCCACTTCA GCAAGAGTGT TTG
AAACCAA ATCTATTCTA AGTAATTTTT TATTCCCTTT TCTCTATGGC ATTAGACACA CAGCTCTTT
T AAACTACCTT TCGTTATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA CTGTCTAGCT ATAT
GAACTT AGACAAACTA ATATCTCTGA GCTTCAGTTT CTTAAAATTT AAAATGAGGA CAATACCATC
TATGGCCGGG GATTAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATC
CAGAT AAAATGAATT AAAAATACTG GCCGCAAACC CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA
GCTTAATTTT CATGCTCACC ATAGCACCGA TTTTCTTCTA AATATTTTGT TTCTACCAAA ATATTT
TGTC CCAATTTTGC CTTTTATGGC TATTTCTTCA TATCCACTTT CCCAAACTAA AGAAGCAGCC C
CTTCACCTT AAACTCCTCC TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGAT
GTT ACAGAGGTTA GTGTGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AG
GCCAGGCT GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGT
TC TTCTCTCTCT ACTTTCATTA CCTTCTCTCT TTTTTTTTTT CTTCTCATGT GCTCACGGGA GCA
GAGAAAA TTAACTCCTC TAAGTTTTCT TAACACAGAG TGCCTTAATT ACATATTACT ATTGTTTGA
G TTCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT ATCAAAAAAA GATA
GCTTTC TCCTAAAAAG GGATTTGGAT GCCTACTAAG ATAACTGGAT GCCAAGATAA GTTTAACCTA
ACAAACTTTA TTATTATTAT TATTATTATT ATTAGAGATA GGTACTTATT CTGTCACCCA GACTG
CAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT CAAAGTCCTG AGTTCATGCA ATCCTTCTGC
TTCAGCTCCC TGAGTAGCTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTTTTAAA AAAATA
ATTA GGGATGGGGT CTTGTTGTAT TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT C
CTGCCTTTT ACCTCCCTAA TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAA
AAC TTTTAAAAGA AATCACATTA CTTACTGTTA TCATCATTAT GGTTACTACC AGTGTTAAAA CA
ATTGGTAT TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTC
AG ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAA
AGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG TTCCTGCCC
C ACCTTGACTG AGGGATTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG CTCCCCGACT GAGT
ACCTTG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCCCTTTGA CTGTAATTTT CCACTACCCA
CCCAAATCCT ATAAAACAGC CTCACCCCTA TCTCCCTTCG CTGACTCTCT TTTCAGACTC AACCT
GCCTG CACCTAGGTG ATTCAAAAGC TTTATTGCTC ACACAAAGCC TGTTTGGTGG TCTCTTCACA
CAGACCATGT GACATTTGGT GCCGTAACTC AGATCGGGGA ACCTCCCTTG GGAGATCAGT CCCCTG
TCAT CCTGCTCTTT GCTCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC C
CAAGGAACA TCTCACCAAT TTTAAATTGG GTAAGTGGCC TCTTTTTACT CTCTTCTCCA GCCTCTC
TCA CTATCCCTCA ACATCTTTCT CCTTTCAATC TTGGCACCAC GCTTCAATCT CTCCCTTCCC TT
AATTTCAG TTCCTTTCTT TTTCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACT
CC AGCACTGGTC ATGGACTTGG AAAGACAGTC TTCCCTTGAT GTTTAATCAC TGCAGGGATG CCT
GCCTGAT TATTCACCCA CATTTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GATCCTTCA
C CTTAGTGGCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCAC
CTCTCC TGGGGGGCAA GTACCCCCCA ACCCCTTCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT
TGCCTCCTTC ACTATGGGCC ACCTTCCACC CTCCATTCCT CCCTTTTCTC CCTTAGCCTG TGTTC
TCAAG AACTTAAAAC CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC TTTCTTCTGC
AATACCGCTT GACCCCAATA CAAACTCAAC AATGGTTCCA AATAGCCTGA AAACGGCACT TTCAAT
TTCT CCATCCCACA AGATCTAAAT AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG A
CATCTGGGC ATTCTTTTAC ACGTCGGTCC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAA
TCC TCCTTCTTTC CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTCTTTCC AA
TCTTCCTT TTCTACTGAC CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCT
CC CCGCCAGGCT GAATCAGGCT CCAATTCTTC CTCAGCGTCC GCTCCTCCAC CCTATAATCC TTC
TATCACC TCCCCTCCTC ACACCTGGTC CAGCTTACAG TTTCATTCTG TGACTAGCCC TCCCCCACC
T GCCCAACAAT TTCCTCTTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GGTTAATGCT CCTT
TTTCTT TATCCAACCT CTCCCATCTC AGTTAGTATT TAGGCTTTTT TTCATCAAAT ATGAATACCT
AGCCCACTCC ATGGCTCATT TGGCAGCAAC TCCTAGACAT TTTACAGCCT TGGACCCAGA GGGGC
CAGAA GGTCATCTTA TTCTCAATAT GCATTTTATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC
TCCAAAAGTT AGACTCCGGC CCTCAAACCC CACAACAGGA CTTAATTAAC CTTGCCTTCA AAGCGT
ACAA TAATAGAGTA GAGGCAGCCA AGTAGCAACA TATTTCTGAG TTGCAATTCC TTGCCTCCAC T
GTGAGAGAA ACCCCAGCCA CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCA
AGC ATTCCTACAG GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG GC
CAAGGAAT GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAA
AT CGGACTGTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTC
TGACTGA CTCCTTCCCA GATCTTCTTG GCTTAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAG
A AGCCTCCTGG ACCATCACAG ATGCTTTTGG TAACTCTTAC AGTGGAGGGT AAGTCCGTCC CCTT
CTTAAT CAATGCAGAG GCTACCCACT CCACATTACC TTCTCTTCAA GGTCCTGTTT CCCTTGTCTT
CATAAATGTT GTGGGTATTG ATGGCCAGGC TTCTAAACCC CTTAAAACTC CCCAACTCTG GTGCC
GATTT AAACAACATT CTTTTATACA CTTCTTTTTA GTTATCCCCA CCTGCCCAGT TCCCTTATTA
GGCTGAGACA TTTTAACCAA ATTATTTGCT TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATT
GCTG CCCTTCTTCC CAACCCAAAA GTGGCAACTC CTTTGCCACT TCCTCTCATA TCCCCCTACC T
TAACCCACA GGTATGGGAC ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCATTA CTATCCC
ATT AAAACCTAAT CACCCTTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTTTAAA GG
GATTAAAG CCTGTTATCA CTTGCCTGTT ACAACATGTC CTTTTAAAGC CTGTAAACTC TCCTTACA
AT TCCCCCATTT TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA GGATCTGTGC CTT
ATCAACC AAATTGTCTT GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA TCCTCAATA
C CTCCCTCCAA AACCCCTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC ATGCTTTCTT TACT
ATTCAT TTGCACCCTT CATCCCAGCC TCTCTTCACT TTCACTTGGA CTGACCCTGA CACCCATCAG
CCTCAGCAAC TTACCTGGGC TGTACTGCCG CAAGGCTTCA TGGACAGCCC CCATTACCTC AGTCA
ACCCA AATTTCTTCT TCATCCATTA CCTATCCAGG CATAGTTCTT CATGAAAACA CACGTGCTCT
CCCTGCTGAT CATGTCCAGC TAATCTCCCC AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGC
CCCA AATCAGGACA CTAAAGTACC TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC C
TTTCCCACA GGGCCTAAGA AGGCCACCGT GGTCATTTCT TCCCTTCTGT CAGACATAAT TCCTTGG
TTT GGCCTTCCCA CCTCTATACA GTCTGATAAT GGACAAGCCT TTACTAGTCA AAGCACGCAA GC
AGTTTCTC AGGCTCTTGG TATTCAGTGA AACCTTCATA CCCCTTACCG TCCTCAATCC TTAGGAAA
GG TAGAACTGAT TAATGGTCTT TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA AGG
ACTGGAC AGTACTTTTA CCACTTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGT
A CAGCCCATTT AAGATTCTGT ATGGACGCTC CTTTTTATTA GGCCCCAGTC TCATTCCAGA CACC
AGCCCA ACTTGAACTG TGCCCCAAAA ACTTGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA
TTCACCATTC TCAACTACTT GTAAATGCCC TGCCCTTTTT TACAGTGCTG ATTTATACTT TTCCT
CCAAA CCATCATAAC TGATATCTCC TGGTTTTACC TCAAACCGCC ACCCTTAAGT CTCTCTTAAA
GTGGATAGAA GATCTTCAGT GACAAGGTAC ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTT
TACT TTTATATTCA CTCTTATTCT TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA T
CTCCACCAC ACTATCAATC TCACTCACTC TCTCCTAGCC ATTTCTAATC CTTCTTTAAC AAACAAT
TGC TGGCTTTACA ATTTCTCTTT CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AA
AGGGGACT CTGCATATTT TTAAATGAAG AGTGTTGTTT TTACCTAAAT CAATCTGGCC TGGTATAT
GA CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTTGC CAACCAAGCA AGTAATTATG CTG
AACCCCC TTGGGCACTC TAATTAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA ATACCTGTT
T TTCTCCTTCT CTTATGCAGA CCTTGTGTCT TCCATTTAGT TTCTCAATTC ATACAAAACC GTAT
CCAGGC CATCACCAAT CATTCTATAC GACAAATGTT TTAAGGGAGG AGACCACCCC TCATATTGTC
TTATGCCCAA TTTCTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGG
CAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG
TTATCTATAG ATTACAGACA TTGTATGGAA AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTC
TAAT TACCAGTACA CGCAGCCCCT AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC A
GTCATGACC CTCTCACGCA GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCAC
TCG GAGAGCTCGG TTTTTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTTCC TT
CTTTAACT CAGTGTCTGA GGGGTTTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCC
AT AATATCACCC CTTACCACAA AATCTTCCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA CGC
CACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAA
A AATTTTCACT GCCCCAACAC TTTACCACTA TTTCGTTTTA TTTTTCTTAT TAATATAAGA AGAT
AGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA
ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCTTAACT GATGATATTC CACCATTGTG ATTTG
TTCCT GCGCCACCTT GACTGAGGGA TTAACCTTGT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC
CCACTGAGCA CCTTGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTTC
CACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTTGG A
CTCAGCCCA CCTGCACCCA GGTGATTCAA AAGCTTCATT GCTCACACAA AGCCTGTTTG GTGGTCT
CTT CACACCGACA CGCGTGATAA TTATTATATT ACTTTTAACT AAAACCCTTT CAGAGTCTCG CA
GGGAAGGC TGTATATATC TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAA
AG GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG GTA
GGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG AACAGAAGG
G AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG AAAGAACTGT ACAG
AGAAGT CAACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG ATGTCTAAAG AATACATTTA
TTCATTTTCC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC TTGCTTCTTT CTATTCTCAT TAAAT
CATTA GAGCTCAAGC AATCCTTCTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA
CTATGCCCAG CTAATTTTTT AAAAATTAGA TTTTAATTTG GTGAACTATT TCTGTAGGAA ACTACA
ATAA TACAGCCCAG GCACATTGAT CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGTT C
CTGGGACTC TGACAATTTC ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAA
ATG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CA
GAGAGAGT AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTG
AC TCCCTGTCCC AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTG
CAGTGAA AATCTGAGGG CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT TCTAATCTC
A GGATAAGGAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGA
AAGCAT GAAAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGTTTCAG ATTCAGTTCA
CAAAGCAGTT TCATACTTAA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT TTCAT
TCTTG TTTTATGGGC ATAGGAAGTA AGTCTCAGGG AGGTTAAGAC CAAGGTTTCT GGAGAATTTT
ATATTATGAA TCTTGATTTA TGGGATTACT ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGA
GCTT GAATATAGAA CTTTATTTTT AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT T
GGGTTCCTT GGCCCTGATG TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTCTGTG
CAC GTGTGCACTG TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTTGCACATC CA
AGATTTAC AGTGTACTAT AGGGAGAATC TTTTGCAACA GCTTTTGCTA TAATACAGAA TCTGAGAT
GT CTTTGAGAAA GAAAAGTGTA ATCATTACCA AAAAATTATT CTCATAATGT GTGCAAATTT GTA
TGAAATC TATATTGGCC ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC TCTATTCTC
T CATAAGAATT CAGCTGTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAG
AGGGTT TGCTGAAACT TATATCAGCA GTGCACTGTA TGCTCTTTCT GATTTATTTG AACATTCATT
TATTGAGTGT CAAGTAATGC ACTAGATACT CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGC
ATGTA ATCTCACTGG GGAGAAAACA AAACATATGA TAATTTCAAA ATAACAAACT AGGCAAACTA
GTTAACACTT AAAAAGCAGG CTTTATTCAA ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTA
AGAA GCCAGGAAGA GGAGCTCATC ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG T
GGGGTTGAG GGAGGCCTGA GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGT
CTG GGGGCAGGGG AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TC
TTCCATAT GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTTCTTA CTAATAAT
AT CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAA
CCCCCAA ACTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCTTT TGCTTGGCAC TCATGAGAT
G CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCC
AGTTAA ATAGGATGGT CCAATTCACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTTCAACTTG
AGCAGGACCC CATTACTTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC TTTTTGAACT TTCTA
TAAGA GTGTACCTCC ACAGTATACA GAAGACGACG TGAAATTTGA TCTGCAAGAA AACTGAGTCC
ATATTCACAT ATGTATCAAA TTTGCACTTC ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAAT
TGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT T
TCCCTTTAT GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTG
GGC TGGGGGTTGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AA
ATCTTCCC AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAAC
GT TTCATGGAAG GATTTAAAGG ATCTCATGAT TTTTAGTATT CCAAGAATTT TCTTTCACCA AGG
GCGATTT AATATGGGTC ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA AAATTGCAA
A ACTTGGAGTG TTAGTAGTAA AGGTAAATAT TCATTAGAGA TGAGAAGAGG AGCAAGGAAA TGCT
TTCAGC TGGAAATCTC AGACAAGAGG CCAGGCTTTA GGAACCTCTG AAGATGAACA AATGTAAGCA
AACCCTAGTA GCAGCACTTC TCAGATTTTC ATGTGCTTAC CACTCAGAGA TGGTGTTAAA ATGCA
GACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA TTCTGCACCC CTAACAAGCT CTTTAGTGAT
GCTTATGCCA CTGGCGCACA GACCCCACTT GGAGAAATTT TTGTGGTGCA TACGGTCTTT GTCTCC
AGAT CTAATGAGTC TGAAGGACAG TGTAGATTGA TTTTTTAAAT TTATGTTTAT TTTAATTTAA T
TTAATTTAA TTTATTTATT TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTG
CAG TGGCACGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA AC
TTCCTGAG TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGA
GA TGGGGTTTCA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACG
GCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTTGAGCAG
T GGAAAGTCAA GGAATTAGAA GGCATGCTTA AATGGAAAGT GAAATTGGAG AAAATTTAAA CTCA
TGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAATTTAAT GAGATGGTAA
CACATTTAGT TTAAAGAAAT AAGTGACACT TTTTTTGTGT GACACAACTG TCTTATTCTT GGAAA
GGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC AGCACCTTTC AAAGGGAGAA CCAGATTCTG
AGGAGCTGGT CTCATGATGA ACTGTCAGGG TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCA
AAAT AGAGACAAAA AAATGTTTCT GAAAACAAAA TTTCACATAT GCCCTCCTCT GAGGTTGGCA T
CATATCTTC CTGTGTATCT TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAAT
GAG GTGATAAACA GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AA
TGCCCAAG GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAAT
TC ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATTT TAC
CTTTGAC TTGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGG
T TTCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAG
CTGGTA GTCAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG
AGTATGGATC TCAGCATTGC CATTTATTGT GACCTCAGGC TATTTTATTT CTCTGTGCCT GTTTC
TTTAT CAGTAATGAA GATGTTCATA GACCCTTCTC CCACAGACTT AAAGGCATAT TTCATGATTT
AAGACATGTA AACCATTCAT AACAGTATAC AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTA
TTGT AACTAACTCT GTCACTTGCT CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA A
AAGAGTTTG AATGTGATAT CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTT ATGAATT
AAT ACAGCCTTGG TCAATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG GCCTTTCTAG AC
CATCTGGT GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACA
AC TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA TAG
TCTCACT ACCATACCAC TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC TGCTTTTCT
C CATATACCTA AATCCTATCT ATTCTTCATA AGCAACCTTC TTTATAACAT TTTCTATAAC CACC
AAGCCA AATGACCTTT TCCTTCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT
TTTTCTGATT TTTTTCTTTC TATATTCCTG TCTTAACTCC CCAGCTAGGT AATAATTTTC CTGAA
ATCAG GGACCAGGCT GACTCCTCTT GCTGTCTCAA GAAAGCTTAG CAGTTTCCAA CACAAAAATG
TTCAATAAAC AACTATTAAT TGACTGATTA TAAAAAATCA GTGAACCATT AAACTTAATA TAGCAA
TTTG CTTAGCATGG TAATTAGCTT TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT C
AAGGACATC TTAAAAAAAA AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGG
TTC CGGTAGCCAG AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CG
AGTTTGAA AGAAATCTTC ACATCTGTGG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAA
AG AAGCCTTTCC TCACTAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG AAT
AAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC TTCACAGCC
A AACATTTTAA AAGAGATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC AGTAATGCTC AATG
CTTGGC CGTCTGACCT CTGTCTTGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACCCTTGTTG
CATCCAGGGG ATACTTACTG GTTCTCTTGG CAATGTTTGA AACCGTTCCC CTTTCTTTGT TTCCT
TGGCA TTCATTACCC CACACTCTTT CTCCTCTTCC TTCTCCCTGC CTGGCAACAT CTTTTCATTT
CTCTTTCCCT TAGGTGACTT ATTAGATAAT GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCC
TCTT CCATTCTTAA AGCACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT A
CCTCCTGAA ATGTGAGGGA CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCC
AAT GAGCCACAGT GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TT
ACCTCCAA AACCTCTCAT TCTTTTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGT
TT CCAGGTGAGA AAGATGATAA TTTGATTCTT CTCTCTCACT TTTAGCCAAT TAACAGACAC ATT
CAGTTAA TATCACCTCC TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA CAGGCGCCA
T CGGTTTTAAT CTAATAACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT CCAGGCTCAC CTGT
CTCCCA CACTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT
GTTTAAACCC CTTTAGTGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATAC
ATTAG TTTATGATCT GGCTTCTGGT GCCTCATTTT TCCCCACTTT TTCCTTTGCA TTCTAAGCAA
TGGCCCATAC TAAGTTTGTG ATTGGTAGGA TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAAT
CATC TCACTTCATT TCTAGCATTT TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC A
CCAAAGTCC TCCTTTCATA GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCAC
TAA ACCCTAGATA CTGAGAAATA TTTTTCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CA
CATGTCTG CATCTCCTCC CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAAC
TG AAAAATACTT GCCTCCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC ATT
TCTGAAG GACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT TTATTCATT
T CTCAATAAGT GCTTGTTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA ACAAGAAGAA CACA
CCACAA TGTTTTTAAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT
GCCCTTTTCT AATAGGGATT ACTTGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAG
CACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC TTATCTGGTC ATTTGGATGA GGACCCCAGG
TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAAT
GAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT G
AAAATAGAA AATAGAGAAA AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTTCAAGT AAGGGAG
AAG GAAGACTCCC ACTCTCAAAA CTGTCTTTTG AAGTATATTA GGTATTTGTT AGGTGGACCC TA
TCTGTGTC AAAGGAGATT TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGAC
AT GTTGATGCAG ATGCCTCCTG AGGTTCCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA TTG
CTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA TCTGCCATC
T CATCCTACCT GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTA
CAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT TTGGTCTTGT TGGTAGGAAT
TGTGCAGCCT CATCTGAGTA ACTAATGTGT TTTTATCTTA CAAACACAAG GAATATCACA TGGTT
CTCCT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA
AACTTTGTGA CATACATTTT TGTGCCATAA CTTCAACCTT GGTTCCAAAT GATTTTTGTA CCCTAA
GTTT AAATTTGGCT TTCTTTTTTT TTTTTTTGTA CTCAATAAAA CATCAAGCTC ATTTATTATT G
CGAAGAGCG AAACAACAAA GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTTGCCCAA ATTGGCT
TCT TTTTCTTACT TTTTAATTAA TTTTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CA
TTCTTTTT GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGA
AT CATTTGGGAG GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA GGT
GAAAGCC CTATTTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTCTTTT CTAAACTAC
A ATTTCTTCAT CTGTTAAAGA GGCATAATAA TTGTATCATC CTCATTGGGT TGATAAAATA AAAT
ATTTCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA TTACTGTTTT AATCCTTTAA
AGTATTAAAG ACTACTATTT GAAATCTTTT CTTCTAAAAT TCAGCCTGCT GATGACCAAG TGCAC
TTGAG CAGGGGGAAT CAAATCTGAA TTAATTTCAG ATTCTGGTTA GCTTCACATA AATATTTTTT
TTAGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTT
TGAA GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG TTTCATGCCC TGGTCTAACC CTGTGTGTTG G
TTCTGGTGG GAAATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTA
GAA GATGTATCTG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GA
TTTGGCCT AAAACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAAT
CA GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT GTT
TCTGGAA CTGTTCCTTA TTCCTTTCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAG
G GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTC
TAGTCA CTTCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT TTTTCTAACT ATTAGAACCC
AAAAAGCCTA TAAATTCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACA
CACAT AGACACACAC ACACACCTAA ACACACACAT AGAGATTTAT GACTTTTTAC TTTTATCCTT
GTAAATGCCA TTAACTATAT TTTGTCTTAG ATTTAGCCTG GGAATGTAGC CATTATTTCT ACCATT
GCCT CCATAGGAAA AATACTCTTC ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA G
CAGAATCAT TTGTAAGTTG GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTTTTT TTTTTTT
TTT TTTTGAGACA GGGCCTCACT CTGTTGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CC
TTGACCTC CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCAT
GC TACCATGCCT GACTAATTTT TTGTATTTTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG GCT
GGTCTTG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGT
G ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTTATCTTAA AGATACCCTA AGCT
TCCTAC CAAGCCAGTG ATCTTTTGGG GCTTCTGTTT TCTTTGTTGG CATAACTGTA ACTAGCCTAA
CTGCCCGTTA TCTGTTTCCT GTTTGCCCCA CACTGATTCC CACAGCAGTT TTCAAGTTAT CGGTT
TGAGA TCTTGTACAG AAATGACTCC AAGGTAAAAA ATTTAAAAAC AACCCCTCTA ATTTTTTTAC
CCTTGCTTAT AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAGTTTGATT CTATTC
TTTT GATTCTACAA ACACTTATTA AAAGATTTTA GAATTCGGAA ATAAATAGCT TCCTTATTAA G
GTGACTTAC AGCCCCAAAG TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTG
TGT AATAACCCAC CCTGTTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GA
CAGGACAA CCGGGGTCAA GATTTGAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGT
CA TTCTTCTTTT GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTTAGT ACT
GTATAAT ACTATAAGAT AGTGAGATTC AATCAGCACA GAATTTCTAA TAGCAAGGGC AGAGACATT
T TAACTGCTCA GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA TCAACAATCC CCAC
CCCCCT CACACACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT AGCGCCCACT ATTCTCAAAT
TTAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATATTTTTGT AATTG
CCAGT GTAAATGGAC AGGGGGCAAC CTTTACATAC CATATTCAGT GAACAGAATA CGTACTAACT
AATTTGATGG AAGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTT
GGTT AGCAATTGTT TCGAGATCAT CCCTGAACTT GAAACAGGTA TATCTTTTTT TTTTTTTTTT T
TGAGACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCT
CCG CCTCCCGGGT TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CC
GCCACCAC GCCTGGCTAA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTG
GT CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CAT
GAGCCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA TGTTACAGC
C TTGAATGGTT CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGG
CTAGTG GGTTGCTCAC ACTTTAAAGC TGAGACACAC TCATGCCTTA AGGTAAAGGG AGTGATAATC
TGGGCAGCAG ATGTTAACTT CTCAAGGCAG TCCTCCTTCT CTTTTCCTCT CCAGTGACGG ATGGT
TGGAA AGCATATATG GTGCATTTGG TTAGAGCTGT GGCCTTGGTG AATAGATACT TGGGAGAATA
CATGGGAATT TCTCCCAGGG TTAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTCTTG AAGAGG
TCAG GTATTTGGGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT G
TAGCATTGA AATCCAAGGC ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATTTTTT CAGAATT
AAT TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CA
GGCAGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAA
AA ATACAAAAAA TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT GAG
GTGGGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA CTGCACTCT
A GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCA
AAGAAC CATTAGAATA TCTCACTTAG TTGTTATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA
TTTTTAAAAG TTTATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTTTTAA TGAAGGTGTG TCCTG
GGCTG ATTTACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTTGGCATC CTGCTTGTGT
TGAATCTATC ACATTTAATT TCCTGTGGGT TTCTTTTTTT TTTCTTTTTC ACTTTAAAGT TGTGTT
CTTT TCATGTGAAG TTAAACTCAC ATACCTTTTT TTAATCTCCT TGCCAGCCAA ATGATAAATG C
CAACCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTT
AAT CATTGAGAAA CTTTTGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC AC
CAGCATTA TTTCCTTAGT CTATCTCATG ATATTTGACT TTTTTCCTCC TTACATCTCC CAGTAGTA
GC CCATTTGATG CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGC
ATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GATTTGTGG
T TCATAGAGTT CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC GTTGTATTTA GCTC
CATGGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA
GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATTAAT GCTTT
TACTT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA TTTTTACATG CCAAGGACCT GCACTAATTT
CTTTCCAATG CAGTAGTTAC CACTTCCCTC TACTTCCTTC ACGAATAAGT AAAAGGGCAT GTTTAG
AGAT ACTCTTGTAA GTGTAAACTA AGTTCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA A
AAAAATCTG TCTCCTGATA CTAACATTTG AAGGAATCTA CTTTTTTACA TATTGGCAGA GGGTCTG
ATT CTATCCTTAG TTCTTCCCAT TACTTTGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CC
AAATATAT GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGA
TG AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA ATA
CACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGC
A CGCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT TTAAAGACTT TTGT
CATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT CACATGCTAG CTTAACATGC
ATTTGCTTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACA
TGATT CTTCTCATAT ACAGATAGAT TTTGGAGGCA TTAGCTTAGT GATGATTCAG GAGTATCCAT
TATTTGGGGA AGTAGGTGGT CATTAGTGAC CTTTTACAGG CATTTCAATG GGCTAACAGA GATGTT
AGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA G
ATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAA
GAT TTTACAGTGA GTTAAGCATA CAAATTTATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TG
TAAATGTT TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TTTCAGTT
TT CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT TCA
CAAATGG TTTTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTA
A AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTC
ACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATTTCT GAGTAGAGAC
CCTCCCTTGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATTGC TTCCA
GGCTT TATTTTCTTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA
GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTG
GAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG C
CGTTTCATC TGTTCTGATA TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCC
AAC TTCCGTAAAT TCCAGTAGGT GGGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CA
CTTCTAAG AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAAC
TT CGTAAGTTCA GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAA
AAAAAAA AAAAACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTTTG TTTTTCAGT
T GTTATTCTCC TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG AATAAGCCAA ATAA
AACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TATTAAGTAG GACACCACAT
AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATTA TTTAT
GCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA ACCATGCTGT ATTGCTATAA GTCATGTTAC
ACACTGGGAG ATGGCTTCAG GGGTATTTGG TTTTTACTTT TTGTTTGGGA GGTTTTTCAA AAAAAT
TTAG TTAGAATAAG TCCTTTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC T
CCTAAGTTT GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACA
AAA CCTCTAGTCT GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GG
TCCACAGG TGGTTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGA
GC TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAG
GCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCC
T GGATTTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG GTTACTTGAA CCCT
CCAACT TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTTTAT CAAATTGATA
TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC TTAGAACAAA GCCTGACTCA TCAGA
AATTC TAAGTAAACA TTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA GTGAGAATCC
TTAAAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCC
CCTG AGTCTACTAG AGTATTGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC T
TCTTTGCAA GGAGAGAATA TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAG
CTC AGTTCCAGAA TTTTAACTCT TTTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CC
TGTTCTGA TTGGTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GTTTTCACAT TTTAGACC
CT GCCATGCCAT TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA GCC
ATTATTG CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATTTTTGT
A TTTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TTTT
TTCATT GATTTAAAGA GTATCTATTA TATATCAAGC ATTACTCTGG GGCTTGAAGA GCTTAGATTT
CACCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG GATTGTCATG TATGTGTGAT GTGTT
TTAAT TGCTTTTAAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATTTGAGGGG AGCTAATTTA
AAATTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTA
GTAG AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA C
CCTGCATAA ATGTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCA
CAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AA
ACATCCCA AAGGACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGA
TC ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG AGT
CAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGC
T CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAA
ACCAAG ACAAAGAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG
TAAAATAGGC ATACCAATAA CATAAGGGTT AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAG
TATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTATTTCAGT
TGGTTGACAT TTAAATGTAT TTTGGTTTTA ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAA
ATTA AATTGTCCAA TTCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CATTTTGTGG A
TCCCAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGAC
GGA CAAGTGAACA GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CA
GAACTAAG AAAGCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCTTAA AGATGACATG TTTTTTGG
CC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT AAG
TGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT GGGTAACTC
A GCCTCCTAAT GATAAATGGC ATAGTTTCTT CCAGACCTTA GAGTTCTAAT TAATCTAACA AGCT
CATTAG ATCGTGAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT CCTTATGGTA ACCCTGACAG
CTTTTATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG AAGTGAGTCG AAACT
TCATG CTGACTTATG AAATCTTTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC TTTCTGATCA
AAACTTCCCA TTTCTCAGAG TGGCTAGTAT CATTTTGTTC CAACCAGCTT CATGATAAGC TATAAT
GATT CCTGTGACTT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG G
GCCCATAGT ACCCCACATC ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGC
CAC TGCATGACCA GGGCTGGCAA GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TT
ACATTTTA GTACTCAAAG TCATTTCTTT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAA
TC AGGAAAGGTT TATTTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT TTTACGTATA AAA
TACACTA AGCATATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC TAATATTCT
G TAACACTTAT AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT TGTTTTTAAT GAGT
GAGAAG GTTAAATGAT GACCTGACCT CAATCATTTC TGCATGCAAT TATTTCTTGG CAATCCCTTT
CTTTATAGAA ATCAAAGATT AAAAAGTCCA AATTTGCTAA AACGGTAGAG TCCAATTTAT AAGAG
ACCAA ATTAACTATG GTTCATTATT AAAACATCAC TTGGAAAATG CTGGCTGTTT TGGAATTGTA
GAAGATTTTA CAGAAATATT CATACACCAA AGATAGTGCA ATTTTTATAT AAAATTATAT AAGGTT
AGAC CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT G
AGCCTAAGT TTCCAACTGG CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTG
ATT GTCTAGCTCT TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GG
GTATAGCT TTTGTGCACA GGGACAAATC TTACACACCA AAAATTCTTA GGAGTGACAC GATGCAAG
AT TATATAGAGG GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT TCC
ATGGGGT AAATCTGAGT ATTCTCTTAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGTCTT
G TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TGGCAGGCGT CATCGTTCCA TTTG
CCTGCA TCTTTGTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT TGTTCTTCTT GTTGTTGGGC
TCACCATCTC CCCAGTTCTC TGCTTCTTCA GTAAGAGATT TGTTGGTTCC CACCCACGTC CATAT
TCCTC CTATCTTCCG GATTCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TTCTCCAGAT
ACTCAATTTC CGCCTTGTTT TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAG
CCCT TTGCCAGTTC ATGGGTTTTT CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC C
AGGAAATCT GCAAGACATC AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCT
AGC ACTACTCCAG GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG AC
CATCTCAG GATCACAGAA TAGTTGTTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CTTGAATA
TA AGATGCTTTT ATCTAAGGTT CTATTTGAAA CAAATTTAGT GGTTTTCTAG GTTTATTTTC TTA
TTAATTT TTTTCTCAAA ATTATTTCAG GTGAAATTTA ACCAACATAT TTTAGACATT CATATTTCT
T TTTCTTTGTA GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA TAACTATACA ATTT
ACGTAT ACTTTTTAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA
TAATAAGGAC AGGAAGAACA GTGACATACT TTTAAGTAAC CTCTTTTACA TAAAAAACAT TTTAT
TTTAC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA ATATACCACT CAACTCTTAT ATATCTAACT
GTATAATTTT TAAAAAGAAC AATTTACAAA GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCA
TGTT CTATACACAA AGAGACTCAA CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA G
GGCTTTGAA GATATCTAAT TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTA
AGC ATGGTATGAT CTACATGAAT CACTATTTAA TACAGTAAAG AAACAGATAT AATTGATGGT AA
AGAGCATC ATAAAATAAA CATTTTGAAC AGAGTTTTGA ATGAGCATTC CACTAGAATG CAAGTTCT
AA GAGGGAAAAA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA TTG
TAGGGAC TCAGAAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA GTGCAGACA
T GGCATAAGGA ATGTGTGAAC GGGAGAGTTA GCATGTTTGC TTGGCTAGAG CTGAAAATCC AGGC
TAGGGA GAAAGAAGAC ATTAGTTTAC TTAGGAAATG AAAAACCAAG TTCAAAGCTA TTGCTGGAGA
GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCC
CCGTC CCTTAATAAG CTCGTATTGT AATTGTAGAA ATGACATTAA TGTACACTGA ACTATGAATA
AAAAATAGAA AATGAGGTGC TAAATATTTG GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAA
TTAA CATTATTCCT TTATAATTGA GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT G
GGCTATTAT AGGTTAAAAA TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGA
GAT GTTTACAGAA GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA AC
TAGTGGAT ATTTAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACAT
AC CACAACAGAG CATTGTCCAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC TCT
GACATTT CCATGGAAAT ATCTGCAAAT GAAATACAAA ATTATATTTA GATGTATACT CTTAAACCA
C ACATTTATAG CCTTTGAGGT GGTGCTTACA ACTTTCTTAA TAATCAGAAT AAAACACATA TGTC
TACTAA CCCTGTCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA ATTACTTCAA ATTTACATCA
GAACTGATGC ACAGTTTTGT TTTGTTCTAT TTTATTTTTA CGCTTTAGTC TCAAGTTGCT AATCG
GTACT GCCCTGAATT TTTTCTATGG TTTGGTAATT TTTATACCTG CTTTTCTGCT GAGCTATTAG
ATAAAACTAT TTAATATTTA CTATGTATAT TTTTTAAAGT ATTGTTGCTG CTTAATTAAC TATTGA
TGCT TATATTTAAT GTTATAGCCT CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA A
AAAAAAAAA ATTAGATAGC CAGACACCAG GAAAGAAAAG TATTTCTTTT TTTAATAAAA AGAAATA
CCT TTTTGAGCAA CTGAAATGAC AAAGTCACAA ATTTCCTGCA CACCTTAAAA TATACTTAAT GT
AAATGACG AGTTAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTAT
GT TGTGCACATG TACCCTAGAA CTTAAAGTAT AATTTTAAAA AAATTCTATC TTCCAAAGCA TAT
CACTTCT CAGGTAGACA CAGTGTTTAT TGCAAAAGAT CTGATTTCAA TAGTATTTCT TCAAGAGTC
T CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA TTTCAGGATC ACTT
TTTTTG AGGGTCTGAG AAAATGTTTA GTTTCTATAT TATTTAAAAC CAGAATTGAA ATGGGGTGAT
TCCTATCCTT GCCACCTGCC TCTACAACCC CAAGAGTTTC TATCTGAGCA TCTAAACGTC TTTTA
GGCTG AAAGGCTCAC CATGGCTTTG CTTGGTCCTT CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC
TTGACTTAGC ACAAGGGTCT CAGGTCCTTG CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCA
CTGA ATGTCAACAG AAAGCCTTGC TTTCTTTCAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT C
CTCCCCTTT TCCCTCCCCT TCCTCCTGCA CTTCTCTTTC CTCTTTCCCC ACCCCTTTCC TAGACTG
GCC TCTATTGCCT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CT
CTCTTCCT TCCCTCCTTT CTATCCTTCC TTCCATTCTC CTATGCATCT TTCCTTACCC TCCTCCTC
CT TCACTCATTG TTGTTGCTGT TCTTCTTCCT CTTCTTTTTC CTCCTGCTCC TCTTCTTCTA CTT
GTTCTTG TTCTTGTTTT TGTTTGGTTC TTGTTCTCCT CTTCCTCCTT CTCTCTCTCC TCCTCCTCC
T TCTTTTCCAC CACCCTCCCC TATCTTTTTC ATAAATGCTA AACTAACTCT TGGCTACCTG TGGT
AAATGG CCCTTGGAAA TTGCAAATAC TACAAATCAA AACTGCATTT CAGACATATT TATGATGTTT
GCAAAACTTC AGTAGAGCTA AGCAGTGGAC TTGACTCGTT TCGGTTCCTT CACCTCCGTC TTTCC
TTGCT CACCACCTAG TGGACGTCCT TGTTAGTGGC ACTTCCTGAA GTTAACCCCT GAAGAGAGCC
CATGCTCTCT AGCTTTTCAC CGTGTAGGTT TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTA
TAAA ATGAGATGGT TTTATAAGAC TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA A
AGGAAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGATTTG CATTTTTAGG AAAATAA
TAA TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATATTT ATTATATTGT TTAATCTTTA TA
ACAGCTCT CTGCTATAGA TATGATTATT ATCCCCATTC TAAAGAGTCT CAAAGAGGTT AAGAAACA
AA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GAC
ACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGATTAAC AAAATAGAT
G GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGAT
ATTACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT TTACACAAAT
AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCA
GGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATTAATAGCC
TACCAACTAA AAAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGG
TGCT GGTACCATTC CTTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC A
TTTTATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTC
AGG CCAATATCCC TGATGAACAT CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AG
CAGCACAT CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTC
AA CATACACAAA TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT GAT
TATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAA
T AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA CAAACCCACA GCCA
ATAGCA TACTGAATGG GCAAAAACTG AAAGCGTTCC CTTTAAAAAC TGGCACAAGA CAAGTATGCC
TCTCTCACCA CTCCTGTTCA ACATAGTATT GGAAGTTCTG GCCAGGGCAA TCAGGCAAGA GAAAG
AAATA AAGTGTATTC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTTTGCAGAT GACATGATTG
TATATTTAGA AAATCCCATT GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAG
TCTC AGGTTACAAA ATCAATGTGA AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC A
GAGAGCCAA ATCATGAGTG AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATC
CAA CTTACAAGGA ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AG
AGAGGACA CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAAT
GA CCATACTGCC CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT TTT
TCACAGA ATTAGAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT ATAGCCAAG
A CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC AAACTATACT ACAA
GGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC
AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCTTTGACA AAGCTGACAA AAAGA
AGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA TGTTGGGAAA ACTGGCTAGC CATATGCAGA
AAACTGAAAC TGGATCCCTT CCTTACACCT TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTA
AATG GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG G
TATGGGCAA AGACTTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATG
GGA TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AG
GAAACCTA CAGAATGGGA GAAAATTTTT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAAT
CT ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGA
TATGAAC AGATGCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA AAGCTCATC
A TCACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAA
TGGCGA TTATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTTT
TTACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT GGAAGACAAT GTGGCGATTT CTCAA
GGATC TATAACTAGA AAAACCATTT GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATT
ATAAATCATT CTACGATAAA GACACATGCA CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAA
AGAG TTGGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA C
ATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAG
CTG GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CT
CATAAGTG GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCAT
GT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG GTT
GATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT CTGCTCATG
T ATCCCAGAAA TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG CCTTAGTCAC ATAA
CTAGTA AGAGACATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC CAAATCCATG CTCTTGATCA
TTAAGCTGAA CTTATGGCAG GAACTTGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGG
AGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTT ACTTTTTTCT
AAGTCCTCTC CTCTAATTCT CTCAATCTCT CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTG
TCAC TCAGGCTAGA GTGCAGTGGT GCGATCATAG CTCATTGCAC TCAAGGAATC CTAGGGTCTA G
TGCCCCTTC TCCCTCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAAT
TTT TTTATTTTTT ATTTTTGTAG AGACAGGATC TCACTATGTT GCTCAGGCTG TAATTCTGTC TT
GAAGCTTG TCCAATCAGG CTTTCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACA
CT TCACTAACAC AAACAGCCTA TTCTCCATCC TCATCTTACT TCACCAGGGA GCTCCTGGTT TTC
CTCCTAC TTCACTGGCT ATTTCTTCTG TATCATGTGT TGATTCTCCC TCATCTCCCC AACCTCCAA
A CCCTTGGAGT ACTCCAGAGA TCACCGCTTT GCTCTTCTGT GTCTAACCTC ACTAACTTGG TGGT
CCAATT CACACTCTTG ACTTTGAATA CCATTTAAAT GCGAACGAAT TCTAAATTCT GTACAACCAG
AACCATTCTC CTGTAGCCAA ATGCCTACTC AACATCTCCA TCCCCAAACA AATTTAGTTG TTCAA
TAAGC CTCTCATATT TTACATATCC CAAACTGAAC TTCTGAATTT CTCCTCCAAT CTGTAGGGCT
CTTCCCACAG CCTTTCCATC TCAGTGGATT ATAACTCCAT CCTTCCAGTT ACTCAGACCA AAACTT
TTGG AGTTAACTGA GACACCTCTC TTTTTTTTCA CAAGTCATAT CCAATGTGTC AACAAATTTT G
GTAGTGGAA ATATTGCGGG ATTTTTTAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATATTTA
TTA TTTAGGTGCA CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGTT AA
GTTACCTT TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAG
AA GTGAGAAATA AAGACAGTTA TTCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTTT TCA
AGAAGAA ACATGTTTTG CGACTTGAGT TTATCTGTCT AGTGACCTTG CAGCTGCACA GCTAGAGAA
A CAGGGTCTTC ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGC
AGTTAA TTTTTAAAGG GCTCCAGCTC TTTCTCTTTC TCAGGGGGAG TTGGGTTTTG TTACATACAA
CTGAGTTTCC GCTTACACAT TATTTAATTT CTTTTAATTC CTGTTCCAAA AGAAGCCAGA TACAA
AAGGT TACATGTTGT CTGATTCCAT TTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG
AAAGTAGATT AGAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAG
TTTT CTTCTGATAA AAATATTTTG GAACTAGATA GACATTTTGT TAGGCCATTC TTGCATTGTT A
TAAAGAATT ACCTGAGACT TGGTAATTTA TAAAGAAAAG ATGTTTAATT GGCTTACACT TCTGCAA
GCT TTACAGGAAG CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTACA AT
CATGGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTG
GG GAGGTGACAG TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA CAG
TACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACC
A GGCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA GAACACGGAT CCAA
ACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA TTGTACACTT TAAGATGGTT
GTTTTATGTT GTGTGAACTT CACCTCAATA AAAAAAAATA TTTAATGTAC ATTCAGCCAA AAGAA
GATTT GGAATAGGAA AGGTCATGGA GATATATTAA CAGCCATTTG ATGGGTGGTA AGGAAAAGAG
TGGTTATTAG ACTGTTTTGT GGCCCTCAAA AGGTAGAACT AGATCGAGTT GGTGAGCATT ATAAAA
CCAT CACAAAACCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TGAGACATGA G
GGAAGTACC AGTGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTA
CCC AACCCTTCCC TAGCCTACGC CTCCATTACA GATGACCGCA AGATTTATTT GCTCATTGCT GC
CAACCAAG GCTGCACTCA CTGCAGTTGC TATCAGTTTA TCATGGGTAA AAGGAATGTG CAGTAGAG
AA CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT TCC
TTACATT TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA CCTAAACTG
T TCTCTCCTGA CCCAACCTTG ATTTTCATCC CAAATGCTTC CTTGCCATCT CTGGGATTCC TGTC
TTCACC ATCACCAAAC TCCCCTCAAT CTTCCAGTTT CCTGTTCAAA CTTTTCTCCT ACCTCCTTGC
TTTGTCATTA GCCCGACTGC CTCCCTAGGA CATCACTTCC CCTGCAGATC TCTCAAGATG ACAAT
ATTTA TTCTCCACAC AGCACATACT TCAGGGTTGG AAGGCAGGGG CAATCTTCTC CTTTATAATG
AGTGCCTCTT ATATATGTTT ATTCATCTGC CCTCTTGTAA AACACACACA CACACACACA CAAAGA
AGAA ATAAAATAAC TCTGCTTCTT TGAAGCTTGT GACACTGAGA TAAACCATCT CACTGTCCTC A
TTGTAGTGA CCTCTCAACT CCTCATGCAA GATTGGCTTT GGCACCTAGT TCCTGATCTT CCTTTCC
CTG TAAGCACTTC TCATAGTCTT ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CA
GATCCTCA GCTCTCCAAT GACATTTTCC TCCACTAGAC TTGAGCTACC TCCTTCCCTA GGCACAGC
CT CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTTCAA ACACTTCACT CTT
TAACCAC TGTCTCCTAT TCTTGCAAGT GTATTGCTCA AGTATCTCAT TGCAATGCTT TTTACTTCT
A CCTCATTGAA CCTCCAGGCC ATTAAACATT TCCTTATTTC TAACCATCAG GTTTCTCCTT ACTT
GTTTGT TTGTTTATTT GTTTCTTTTT TTTTTTTTTT TTTGAGACAG GGTCTCACTC TGTTGCCCAG
GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTTCAAGTGA TTCTC
ATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGATTTTGT
ATTTTTATTA GAGAAGGGGT TTTGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGA
TCCA CCTGCCTCAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT T
TCTCCTTAT TTATTTCAAG TCTATGCTGC ACTATTAAAA CTGCCTTGAC AAAAATTATA ATAGTGA
GAA AATTATGACA GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCTTT ACCTTCCAGA CT
GCCCTTAA TAATTCCTGA GCTTGGGCCA AGCTATCTTT GGCAGAAATT TAGTTTATAG TTTAAATG
AT AATAGCCCTT CTCCAAAACT AAACTGCCTT TGTAAAACTA ATAAAAGACC ACCAATGAAA GGT
TAGGAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC TGTTATTCC
G GAGGTCACAA GATTTGCAAC ATCGCCAATT ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTG
ATTGGC CTTTTGAGAT GTCTTTTCAG ATTCTTACAT TTCAACTGGT GGCTCTACCT GGACCCATCA
ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CTTAACATGC ACAAGGACCA TTTTCCACAC CGCTA
TGATT GCATCCCAAC CAATCAGCAG CAACCATTCC TCTGCCTGCC AAATTATCCT TGAAAAATCT
TAGCCTTAGA ATTTTGGGGG AGGCTGATTT CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGG
CTCT GCATGAATTA AATTCTTTCT CTATTGCAGT TCCCATCTTG ATAAATCACC TTTATCTGGG C
AGCAAACAA AAGGAACCCA TTGGACAGTT ACACTGTTGG CAGATATATC TTGCTTCCAA AATTGGA
TTT TTGTTTAATG AATTTATTCT GTTTTCTTGA TATTTACAAC TGTGAATGTT GTGTCTGAAT TC
TCTTTATT TCTTGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG CTAATTAC
TC AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA TTGTCCACTT TTC
CCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA AATACCACA
T AGACATCAGG GACACTTTAA ACTAATCAGC CTATAGTCCT TTTTCAGTAA TTTCCAAACC TGGT
TGTGCA TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA
TCCTACTGAA TCAGAATATT TTGGGTTGGT TCAGGAACAT TCAGGAGTTT TTCAGGGTCC AAGGT
TTATA TAATTTGAGG TCTCTCTTTG AGAAAAGGAA CGTAAAAGCG TCTTGCTTTT ATAGATCTTA
CAAAGATGTA TTACCATGTA AACACATTCC TAGGACCCAG GCCCTTGTAA TTTAAAGGTT TATCTA
AGTA ATGGGCCCTG AAGCTTAATT TTCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTTT A
GGAATATAT CTCTCTGTGT ATGTGTGTGC ACATTAGCAT GTACGCTTGT GTGGATTTTT TTTTTTT
TTT TTTTTTTTTC TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CT
GCTCACTG CAAACTCCGC CTCCCAGGCT CAAGCGATTC TTCTGCCTCA GCCTCTTGAG TAGCTGGG
AC TATAGGCACG CACCACTATG CCCAGCTAAT TTTTGTATTT TTAGTAGAGT TGGGGTTTCG CCA
TGTTGGC CAGGATGGTC TTGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTG
G GATTACAGGC GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGTTTTAAGC TCCCAGGTGA GTGA
ATACAA AACTAGATCT TTCCCTTCTG TAGCATCTGT ACTGTTTACT CTATGCATCT CAATATTTTT
TCTTTTAGTA TCTTTCCTTT TTCTCTCTTA TTACTTCCTC TTGTGCTATT TTTACACCTC CTTTT
TTAAA AAATTTTTTC CCTTTTATTT CTATTGACCT TTAGCCCTCA CAATGATTCC TACAAGCCCC
ATTTCTGTAA ATGGGGATTG AAATAATTGC TGGACTTTTG AGAGATAGAT ATATTAAATT GCAAAC
TGGC AGTAGTGGGG GCAGTTGATA CATAACTAGG TTTTAAAGTC TAGCCTTCTG AGACCACTCA T
TCCATTTGT GAAAAGTGAT TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC CATGCAT
TGA TTTATTCATT CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TG
GGAATACA GCAATGAACA AGGTAATTTT TCCCTACCCC TAAGGAACTT AGAGTTTAGT GGGGAAGA
CA GACATTAAAC AAACAATTGT GCAAGTAATA ATCTATAATT ATTTATTACA ATTAAAGGAA GGA
AGAGACA TATGGATTAT GAGGGCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC TCGTGAAGG
G ACATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTG
TGTGCG TGTGTGTGTT GGGGTGTGGG GGTGTGGTAT TTTTTATAGA AATTGTCTCA CACAATTATG
GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TACTT
CAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA
GCTTAAAAAG ACAGTGAATT CACTCTTTTT GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCC
ACCC ACATTGGTGA AGGCAATCCT CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT C
TCACAGACA CACTGAGAAA TAATGTTTTA TCAGGGTGAT AGAAATCTTC TGGAGTTAAA CAATGGT
GAT AGCTGTACAA TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG TTTTATCTAA AT
AAAATTTC TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATTGTCAAC CTTTATAG
TG TTATGTCAAA TAGGTCTGAC ATAAGCTTAA ATAAATATAT ACTTTAAAAA TTATAAAATA TTT
TAAGTTA TAATTTAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTATTTCA CACAGCTAA
T TTCTAATGCA GTTTACATAA ATATTTACAA CACTTAAACA ATTTCAAAGA AAATAACACT GTAT
TCCATA CATAGCCTGA TCACAGTAGT TGTTCTCTCT TATTTCCCAG AGTTTTTCTG CCCCTTTAAA
AGAACCTCTG CTGTTCTGAT CCTTATCACA TCTCTGTTTT GACTGTTGGC TTTGTTGTTG CCAGT
GTTCA GCCAGAACTT CTCTGAAACT TTTTTTTCAA CACATGCTAA GTTAATGGAA GTGTAGGAGA
GTTTTGATTC TCACACTCCT CAAGGCTAGA GCAGCTTTGG CAATTACTGA CTGAGAATTT TTCATT
GCCA GTGATCAACT GAAAACTGGA GATTCCTTTG GAATTGTTAA ATCTGCTTAT AAATAAACAT A
AATGCTTGC TCACACAGGC ATTCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGG
GAA TAACTATTAG ACATCTTCAT TCGTTAAAAA TCTACCAGAT GACTCTTTTA CATGGTGAGT TT
CTATTGTG AATTTAAAAT CTTCCATAAT ATACAAGAAT TATGTTTACA TATCATATCT GACAAACA
TC TTTGTAGGAA TGCAAAGCAC ATCCATCTTT CTGTATTCTT TTCCAACAAA GACATTCATA AAA
TTATACC TTTGTGTGTT TGCATTTATG CTTTTATTAG TTCAAAACGT TTGGCCTCAT GGAAGTTTT
T CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC TTCCATTCAG TTTT
TACTCT CCAATTCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA CACTCAGAAC TTTATTCTGG
TTAACATCAT GCCTTGCTAG GGGACAATAG TTTCCCTTTT TGAAATAAAT TTAAAACAGA TGTAA
CATAA TTTGTTAATA AACAATGAGG GGGTAATCTA GAATAAGTAA CTTTTACCAT ATCATAGTTG
ACAGCATTTA CAAGTTTTTT AAGTCCCTAC CACACTTGTA TTGAATGAAG AAGTATGGAA GATTAT
AATA TATTCAATGC AAGTAAAAAT ATCACAATCC TTAAGAACTC TTTAAGAAGC ACTGAATCCC A
TAGGGATGA AAGTGATTAA ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TTGCACC
ATT AACAACCCTC CATGCATTTG CCTGTGGGCA TTCAACATCT GTCATTTTTT TAAGTTATAA TA
TTTTTAGT CATTTTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGT
AA TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG TGC
CAAGATT TTACAGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC TTGGTCTCT
T CACCTTTGCT TGGAAGAAAA TATCCTTTCC CTTCATTAGC CAACACTTTC TTGATCCTGA GAGT
AGGAAA GGGAACACTG AGTCTTTTCA GTTGAAGGCC GTCCTTGCCT GCTGGACTTT GATCTATTGA
AGTGGTGATG GGTGTTGCGG TTTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGA
GACCC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA GTGTATCCCT CTAGTTCCCC AGATGCACCT
GTTTCTGTAA ATATAAACAT GCATGTCATC AGAACACTTA ATATTCTGCA TACTGATCAT GACAAC
AAAA TGTACCTTCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT T
CAGTTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAG
CAC AGAGTGAATT CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC AT
CAGTTGTA ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTT
GG AACTCTTTGT GCTTTCTGCT CAATTTTTCT GTAAACTTAA AACCGCACAC ACAAAAAAAG TTA
TTTTAAT TTTTTAAAAA GTATTCAGAG GGACTTGACC TTTCCAAATT CTCTCAAAGC AGGTCGGAG
T AGTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC TACACCACTT ACTA
GCTTTG AGATTTCAGA CAATTTACTT AACTTCTCTG TCTCATTTTC TTCATCTGTG TGATAAGAAA
TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTTT GAGAGGCCAA GGCGG
GTGGA TCAGGAGTTC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA
TACAAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGG
AGAA TTGCTTGAAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT C
TAGGCAACA GAATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAA
TAT AGTACCAGCC CCTATCTCAG AGTTCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AA
TGTAAGGG TCAGCTATCT TCATTATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATC
CG TTTCTTTCCT CTCCTTCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG ATT
TCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG AGCATGTAG
A GAAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC TTTTGAACTT AAAG
GATGTA AGAAGGCTTT TGGTAGCTTC CATCTGATTC AAGGCTTTGG CAGCTGCTGT GGAATACATG
AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGC
ATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TTGCTGCAAA AGAAAAGACA
AACAACCATT AATTCAGACT AAATGACTTT TAAGGATATA TTAAATCCAG ATACAATATG ACTTAA
TTCA TCAAGTGTTG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT C
TGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCA
GCA AATAGCTACG GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CT
TAATTTAA ATGTGAGATT TCCTATTTTG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACT
CT TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA GAG
ACTCTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT TTTCCTTAG
A GTGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGC
ACCCCC TGGAGTTGTA CAATATTAGG CACGACTAAC ATTTTTATTT CCTGAAACAC TTCCCACACT
GAGTTGTACT ACTAACTCTT TTCTTAATAC TTCTGCTTAA TTATACTGCA TTTTATCCAG ATTCT
AATTA TTGTTTAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATTTTCAAAA
ACATTTTTGA AGTACATTCA TAAACTTCCT CACCTTTCCG TAAGCATTTC CGAAGCCAGA GGAGAA
ATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA C
TCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA AGTCTCT
CCG TCCTGTCCCT TTGGCCTTTT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TT
AATACAAG AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTA
TT TCCACCATTG GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC TTG
GTTAATA AACACTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT TCCCCTTTC
T CCTCTCCTCT CTCTGTCTCC TTTTTCCAGT TGTCAGAATT CTACCCTTTC CATCAACATG CAAC
TTCTGT TTTTTCTCTA TCCCCATACA ACTTAATATT CACAACTTGT CAACCTGGGC GAACTTTCTG
GTTTGGATAT AATGAATAGT TGATTACTGT AACAAGATAG CTCCCCCTTT TTCTTTTTAA TCACC
AGACA ACCACCATCA ATCAATGCAT CACCTTCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT
GGCTCCACAT GTCCGAGCTG CAGAGCCATT GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACAC
AGTG CCAAACACGG GCTCCCCACT GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA C
ATTTTACCA CTGCAAATGT TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAA
AAC TTGCTTAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTTTTC AGCATGTAGG AA
ATTAGGAC CAAACCCCTT TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCC
TA AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG AGA
TGTGCAC TCAAGTTGAG TTGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGA
C TTGTAGGTGA ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGA
CAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA GTTTGTTTGC ATCTCCAGCA
ATACGTTTCC CAAGGTAACC AAGTTCCCAA GCTCTTCAAT AGTTCTTTTT ATCTTAAAAT AAAAT
AAAAA CAAAGACTGT ACCTTCACAT GTGGGCTTCT CGTTGTCCCA CTCCCCTGTG GGGCCACATT
GGAGCCTTTT GGATCCCTTC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAAC
GGAA ACTGCCAGAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT G
CACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGG
CGT TTGTTGAGTG AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CC
CTGGACAA ATGGGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAA
TT AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATT
ATGGTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT ATAGATGGT
G CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTTGCAG TTTGGTTTTT GTGT
TATGTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA
AAAACTGCTT GTTTTCAATA TCCTTGCTCT CACTTTAAAG TGAATTAAAA TTTACTGCTT ATATA
TGCAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG
CCATTTCAGA AGACAGGTGT GATGAGAGTT TTACATTCAA ATCATGTTCT CATTATTCTG CTTTCC
GAAT TTTCTAATAT GATTCCTTTA GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG T
TTTATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TTCATTCTTA ACACATATGA TCCTTTC
CCT GGCCAAACAT TAGTTCTTTT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG AT
TTCTATAG TTAAAGTGGG TATTGGTTTT TTTTTTCACT GTCCAAGTTT GAAGATGGTT GTTCTTTA
AG AAAGTATAAA TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT GCC
CTTGAGT GGTGCATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTTGC
A GGATGATTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCATTCTG AGGC
TGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG ATATTAGCAC GGCCTAGAAT
TAGCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACA
ACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA ATTCCCAGAT GAGGTACACT GAAGGCTCTG
GGCTCCCATT AGTTCAAATC CTTCTTCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCC
AGGG TTTTGGAAAC ATTCCACGAA CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT G
AGGATTTTA AAGAGCACCA TGAATTTTAC AGAAGAATGA TCTTTTCACT TCCTATTGAG CTGGGTG
CCT AACAGAGTGA GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GA
CATGCACA GCCAGAATAA AAGCTTTTAT TCTTTTTCAT GGATATTCTA TCTTTTCTGA TTTCCACT
TT GCCTATGCTG AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA AAT
AGATTCC AGATTAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT TAGCCCATC
A GAGCCTGAAG AACTGATTTT TCTTTTTTTG GCCTCTGGTT CAGAAAGATA AAATTAAGAG AGAA
AAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTT AAGTTAGTCC CATGGCTTGG AAAAGTTAAA
CAGGGAAACA AGATGAGAAA TCCATTGAGA TTTCTAGAGC TTTATTGTTT TATGGTCTCC CTTAC
AAATC ACCAGAGCCT CAGAAACACC CATTTCAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG
CAGGTACTGG GTTGGCAATA TACATTGGCT GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAA
AAAA CTTTCCCTGA AGTTTTGAAA ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG T
TACAGAACG TTCTGTGCAT TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTC
TCC AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AG
AGCAGGAA GAATTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGG
AT TCCAGGGCTG TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA CCT
TTAACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTTTT TTTTTTTAGT TTAAAAATT
T ATAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTTTT CTTTTATTCA AGAA
AATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT
GATATGGGGA GAGTAGTGTA ATTGTGTTTA CCTCAAAACT GTTCAAATTA TATGAACAAA CACAG
CAAAC TTAGGTACCA CAACAAATTT CTTGTTACTT TTCTCACAAC TGCTAAAAAT ACTACAGTAA
GCTTCCAACC AGGATGAGAA CCATTCACAA AGCTATATTT CAAATTTAAG TACTAGAATA CATTAC
AAAT TTTAAAACCC TAATGCTGCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA T
TTAAACTTG AATTCGTTGA AATCAAATAA CATTTAAAAT TCAGTTCCTC AGTGTCACCA GCCACAT
TTC AAGTACTCAA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TT
TCCATTAT CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAA
CT CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC TAC
ACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCAC
T CATTTCTACT GCAACGTCTT GTTACCACCT AGATGAGGTG AGTACATGTT CCTCGCAGGG ACAC
AGAATT ACAGTTTATT GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGTTC
ACACTATTAT TATCCTCATT TTACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG TCAAG
GTGCC AAAATAAATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGACTT CATAGTCTCA
GCTCACGATC ACCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATG
CCAG CTAGGACGTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT T
TGCTCACAC TTGAGTCCAC TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACA
CAT TCACCGTGGC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GA
GGAGGACT ATTACTGTGC TTATACTGAG TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACAGAGAC
AT CAGCAGTCCT ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG AGT
TTCAGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAA
T TTACTTCTTC ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG TAATTAAAAT ATGT
ATTGTG TGTGTGCATT TTTATATGTA AAGAACTACA TATTTGCCTA CAGTATTTAT ATATATTTTA
TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAA
TGCTG TAGGCTATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT
ATATATATAC ATATCCACAT ATTCTTGCCC ACATTCACAC AAAACAGCAA AAGAGAGAAA CTTTAG
CAGT TAAACAGAAT CTTTTGGAAC ATAAAATGAC CACAATAGAG AGCAGTTTTT GCATGCTGTA A
ATTTGCCAA GATGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAG
CAT AGGGCAAGCT TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC TTTTTCTCTC TT
GATGTAGA TCTCCACGCA GTCCTCATCT TTTTGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTT
GG CTTCTTCTGT CAGAGGTTTC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACTTTTCTGA TTC
CAATCCA GTAATAACTT GGTGAATAGC TCAATATGGA GTTTAGGTAC TCAATCTCTT CTTTGTTTT
G AATTGCAACC AGGTGTGTGT ACCTTTGCTG ACAATAAGCA CTGGCCTCAT CATAAGTCAT AGCT
TCCGTG GAGGTGTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA GCACTAGTGG GAGAAAAAGA
AAAGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT GACAACTGTG CTTTTTATTG TCTTA
TTTTT GGCAATGTTT GTGACATGGC CCAGACTTTT CTCATCTTTT CAAAAGTAAG AAGTACGTAT
GAAGAAACAG CGACTTATTG TTTATCTCTT TTGTGACTGC CACCCACTAG GTACCTTATC CACACT
CACT CACAACATTA TAGTATACCC ATTTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT T
GAGCACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC TTTCCATGAA CCATGCTATT GAATCCT
CAC AATGCATCTG GGAAATAGGT CATTATGATC CACACTTTAC ACTTAAGGAA AGGGAGACAC CA
AGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGC
CA GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG TGC
GAGAATG AGAAATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAA
G CAATCATGAC TTCAAGAGTT CTTTTCACCC AAAGGTTTAG GCTTGAAATA CTTTCCTGGG GAGA
TAAAAC ACAAAATGAA TTAAAGAAGG AAATCGTGGG TAGCTAGTTA CATTATTCTA CCATGATGTT
TAAGGCAGCA TCCTAAGATT TTGGGCAAAG GACACTAGTG CAATAATCTT TATTTCAGAG TTTAA
TCAAA TAAATAAACA AATTTTAAGA CTTTCATTAT TTAGGTCAAA GAGAAAAGAC AGGTTTTAGC
TACAATACAA TAAGAGCTTG TACAGATGTG GTTTTTATTA GAAGGCCTTT TGCATATCTG TGTTTC
ATGG CCCGAGGCTG CCCTTATAAA GCGTTCTGCA CTTACCGTTT TGGGAAGCAG TTGTTCAAAC A
CAGGATCTC TCAGGTGGGT ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTTTTG ATGTGAA
GTC AGCCAAGAAC AGCTGAACAC TACTTCGGCT GAGGCCCTTT TATAGGAGGG ATTGCTTCCT GT
GAATAATA GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTTTC
CC GGGAATATCC ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC TTGAAGCTAC TTC
ACCTTTG TCCATGCCTT TATATCGTAT ATGCAATTTT ATTAATATGA CAAAAATGCA TGATTTTTA
A TTATAATAAC ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG TTAGTAGTGT CTCT
CATGTA GTTGTGGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC AAGAATAGGT TTGTCATCCA
TAGTCTACTA CCTTCAATTT CTCATTCATA GCTGTGGATA ACCAATCACT ACTCATTTTT TCTTC
CTTTT TCACCTGCCA ATTCAACATA TTTAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT
AGATATTAAT CTTCAGATTT TGCACGGCAG TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATAT
CTAA CACTCAAATG GTTAAAATAA TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT A
CATCTGGGA AAGTTTCATG GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCA
CGC CTGTAATCCC ACCACTTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GA
CCAGCCTG ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGC
GC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG TGG
AGGTTGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTA
A AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTT
AATTGG TCAAAATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA AGAATAAAAA TTCTTCCACA
ATGTTAACAG TGACTAACTC TGGATGGCAG GATTTGGGAT AATTTTTATA TCCTTCATTA TTATT
TTCAG GATTTTAAAG TTTTTTTCAA TTTCCCTTTT TTTCACCTTT ATAGTAACAA GAATACAGTT
TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCT
GAGG TGGGTGGATC ACCTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG T
CTCTACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGG
AGC CTGATGCAAG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CA
TTGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAA
AG AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCT
TCATTTT GACATTTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAAT
G ATGGTAACAG TAAATGGGGA TCATTTTAAT TTCCATATTC TGTAGGTTTT CAGAGCTCAA GTCA
AGCTAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA
CCTGAACGAG TAGTGGTAAA AGCCTCGTTT TTCTCTTTAC TTGTTAGCAC TGGTCTTTCT GTGTT
CATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATTCCAAA AAAGACAACT
GATTAGAAAA AAATAACTTA ATTAACGAAT TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATT
CCCT CCACCTTACC ACTCTCTTAC ATGATCCAGA TACTGACATT ATTCCAATTC TTTATCCCAC T
TTACTTAGC TCAATGTGGT TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTAT
TTA GATTTTAGGG CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTTTTAA TA
AAGTATGA ATACATAATC TGCTATTTTT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTA
AA AAACAATTTA TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG TCG
TTAACAT CCCTAGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA GTTTATCTC
T TCCCCTTTTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTTTC TATT
TTACTT ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TTTATTGAGT GCTTACTATG
TGCCAGGCCA TATTCTGAGC ATTTTGTATG TTCACCTATT GATTATTCAA TCCGTACAAC AGCCT
ATGAA ATAGGTACTC CTATTATCCC CATTTTACAG ATGAGGAAAT TGAGAATCTG GGGATTTTAT
CTCATTCAAA AGCACAGAGC TAAGGGTTGA AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTAC
CTGC TACTCCAAAC CATGATTTCT TTTGTTGTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT T
CCTGTACTC TTCTTGCCCT CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAA
CTG TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GA
GGATGCAG TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAA
AC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA GTT
CCTGATT CAAAAGCAAA TTTTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT CTAAACTGA
T TATTTCTAAA TTGAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGA
GTGGAA GAGATAGGTG AGTAACAGTA ACTTAAATGT AGACTATATA TAATATATAA TATATGTAGA
GTATATATAT ATAATTACAA TATATTATAT ATGTGGAATA TATATATTAT TTATATATAT TTATA
TATTT TATATATATA GATATTTTTA TATTTTATAT ATAAATATAG ATATTTTTAT ATTTTATATA
TAAATATAGA TATTTTTATA TATATTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGA
ATCT TGAGACCTCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA A
ACTGCCTTC CTTTTGTTCC CAAATACCTG TAATTTCACA TGCTTACTTT ATCTTATATA AAATGTA
GAT GTACTGAGCA TGAGATCCAT GCATAATTTC CCTCTAGTCC CTTCTTTTTA CATGTAAAGT GT
AGACTCAC TGAGTGTTAC AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTT
CG TTTATTTTCT TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCT
TTGGAAA AAGCGCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC AAAATAAAC
C TCTAATCTGT TGAGATATGC TTCAGTTACT TTTTGGTTTA CAATATGTAC ATGTATGTAT ATAA
TTTATA TGTATATAAT ATATGTACTT GTTTTAACCA GAGGTATGTT ATTCAAAATC CATTCATCCT
TACAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC TGCCCCCGAG GTTGTCACTG CAAAT
CAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT
AGACAGACCC AGCTTTCCTC TCGTGGAGAG GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAA
CCAG ACTATAGCTT CTTCACCTGC TTTTTCCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT T
TTGAGGGTG GGGGCAAATC AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTTGAATAGT TGGGCAT
GTT GAATATTATG AATATCATCT CCCTCTTCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CT
GATTAGAG GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGG
AT TGCCGGTTTT CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG CAT
CCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCT
G CCACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT CTCTTCCTGG AAGT
CTCTTG TCCTCTCCTC CACACCCTTT AATCAGGCAT CAAAGACTTT AACCAGTTTT GCTGTGTGCC
CAGGCCCACT CATTCTCACT TTTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAG
AGATT GGGGACCCCA AGACAAATGT TAGAATTTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT
TGGGTTTAGT GGAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAG
TTAT ATTTGGTGAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT C
TGTTCCCTT ACCTCTGCGA AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCC
TCT CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AG
GGAGGAAA TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTTCTT GCATTCCC
AA AATTGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA CCT
AAATATA TTTGATGAAA ATGTGTCTGG TTCTAAGTTT ATTTCCCAGA AAGCCATGTT TACTCACTT
G GAATTTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTTT
CTCCCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA AGAGGAATCA CCTGGACAAC
TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCG
CCCAA GAATTTGGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA
GATCCTATCA CACTTAGATG TATTGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCC
CGTG GTTGGTGCTC AGCTATAGGT ACCAGAATTT TGATCAAAAT TTACTATCAT TGTGACACTT C
TCTTCGGAA CTGGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGG
TGA GTAGCATTTT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AA
AAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTTTTCTC
CT CTGATTCCAG AGGACTTTGT AATTCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG ACT
TGAATTT TTCATGTGCT TTTTGCTTCC TATTTGGCAG CATCTTATCT TGAAGTTTCC GCTTTCTGC
T TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAA
AGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT TTCCTGAATG TAGCCAGACT
GTTTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT GGATTTTAGA AGAGCCCCTT GTTTG
TTTTC CTTGGCCATT TGTGCTGCTT GTTTTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC
TTTGTTCTCA CGTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTTGGATTTT ACTGTA
TTAG AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC T
TTTTTTTCT TCCCCAAATC TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTA
GAT CTCTTTAGAG CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TT
GGATTAAC CGGATAACAA TGAATATTTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTG
TA ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCC
TGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT GGTGCAAGA
C TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTG
CAGTGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA GCGAAATTCC ATCTCAATAA
ATAAATAAAT AAATACAGTG ATTTAACACA AGAGATTTCT ATTTCACACT AATGAGCTCT GTCAC
TGGGG CAAGCTTCTT TGCCTCATTA AGTCTCAGAT TTCCCGAGAG CTTATTTATT TATACCAAGA
GTGCTTTACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGC
ACTA ATTTATATCA AAGCGTTCTT CGTTTTTCCT TGCTGTGAAG TTTTTAGCTA ATAATTCATA A
GAATATACC ATATTTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACA
AAT TTTACAAAGT GAAAGGTAGA TATTAATCTC ATTTTATGGA GGACAAGATA GAGATCTGGA GA
GGTTACAT AACTTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTAC
TC TAAAGTCCGT GTCCTTTTTA TTGGCTCCAT GCCTACTCAG ATTTAAATCT CAGCAGGGAA GTA
AACCTTA GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC CATCCCAGT
T TCACGAGCTT AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA TAAGGATGTG GGTG
CCAGTC ATTTATTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA
AAGGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT ACCGCTGTGG GCAGCCATGG GGCTC
AGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG
TCTGCCTAGG GTATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTT
AATT CCTCTGCACT TTCAAGTGGA TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA T
GCTTGTATT TAAATCTGAC ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTTTCT
GTC ATTACTGTAA CAGATTACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TA
GTTTGTGT GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTTTCAC ATTGCCAA
TA TCAAGGTGTC ATCCAGTTGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTTCAAGC TCA
TTCAGAT TGTTGGCAGA ATCCAGTTCC TTGTGGTTGC AGGACCAAGG TCCCTGTTGC CTTGCTGGC
T GTTGGCCAGG AGTCATTCTT AGCTTCTAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC ACTT
CACCTT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTTCAAATG TCTCCAACTG TGCCTTCACC
TCATTTCTCC TCTGTGTACC ATGTCTGCCT CTACTGCTTG TAAGGGCTCA TGGGATTACA TTGGA
TTTAT TCAATCCAGG ATAATCTCCA TATTTTAAGG CTAGCTGACT AGTGATCTTA ATTCCATCTA
CAAAGTCCCT TCCAATAGTA CTGTATTAGT CCATTTTCAT GCTACTGATA AAGACATACC CAAGAC
TGGG CAATTCACAA AAGAAAGAGG TTTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC A
CAATCATGG CAGAAGTCAA GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGA
GAG CTTGTGCAGG GAACTCCTCT TTTTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CA
AGAACAGC ATGGGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATG
CA GGAATTCAAG ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA TGT
TTGATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC TGCCCACCA
A GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTTT GGGAGGCCAA GGTGGGTGGA TCAT
GAGGTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCATTT CTACTAAAAA TACAAAAATT
AGCCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCACT
TGAAC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA TTGCGCCGCT GCACTCCAGC CTGGGAGACA
GAGCAAGACT GTCTCAAAAA AAAAGAATTC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAAC
CCAG GAATTAGGTG AATGGCTAAC CTAAATTAGC ACTGTGATGT GTTTTCTGAC TTGGTCCTTA T
AGCTCCTCT GCTTAGATGT GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTTA AGTGGGA
GTT AAATATCCAA AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TT
TCTTGGAT AACCCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTC
CC ATAAATAGAC ATTTCATTTT GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC AGT
TATCATT AATTGGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG TCATTTGAT
C ATCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA GGCACTGAGG GTTA
GAGTTT AAATAACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT
CCATCTGACT CCAAAGTCTA TGTTCTTGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGTT
TTACT ACTATATTCA CACTCTACTA ACTTTACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA
CACAGCACAG AAAACACATG AATGCAAAAT AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAA
TACC TGATGTTTGC TCTAATCCAG TTTTACTATT AATTAGTTGC TGGTGCCCAA GTTTTTACTG A
GAAATGGGG ATAATTTTGG AAGTCATAAT GATGCCTTCT TCTCATAGGG TATTTTATTT GTTGTTG
TAT CTCCAGGCCC CAACACAGCC TGGCTTTTAG TAAATGATCA AAAATACCTG TTGAATGAAT AA
ATGGAGTC ACCTGAAACA TGTTAAACAT TTGTTCATGT GTCCTAATCG TGGATTTCAG GATAGTAA
GC ATCCTAAAAG GAAAGCATGC ACACTGTTCT TGCTACATTA ATTTCTCACA ATATAAAAAA AGA
AAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGA
A GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA GTCCTGGGGG TCAG
ACCCGA GGAGAGCAGG AAGTGTCTTT TGAGGGATAC ATTTCCACAG TGGAAATAAT GAGACTTAAA
TAAATATTAT ATACACAGTT CAACTGTTTT TATGTGTAAA GGTAGTAGGT TTTCACAGTA AGGAA
GCACT TCTTTTTTTT TTTGTTTGAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT
GCTATCTCGG CTCACTGCAA TCTCTGCCTC CTGGATTCAA GTGATTCTCC TGCCTCAGCC TCCCGA
GTAG CTGGGACAAC AGGTGTGTGC CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC G
GTTTCACCA TGTTGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGTT CTGCCCGCCT CTGCCTC
CCA ATGTGCTGGG ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TA
CAAACCCT TCTTAGAATA TTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTTCCCAA CTAATACT
AG GAGGTTATAA CCTTCATACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGC
CACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCC
C GGCATGGCCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATA
AAGGAG TCAAGGTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT GTTACACAGG TTGAAAAGCT
AAGGTTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTG
CATTG TCCAGAAAGG AACTGTGGAA GATTTTGGGC TGAATTTCAA AACAGAATTT CCTCACTCTC
TGGATGTTGG CTTACTTGGC CTTTGATGTT CAGAGGTGGT GCCTTTGTGT TGTTGAACAA TGTTGA
TTTT GGAGAGAAAA CAGAGTTGAA AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC A
GAGGATAAT TTCAGCAAGC CAGCAAGGCC TCATCTCTGC TTCTAATAGA TAGGAAGAAA GGAAGAG
AGG AACAATACTT TTTTAAGAAG CTCAGCTTTA TCGCCTTATC TCATAGAAAG ATGCCTCCAG TC
TGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGTTTCC
CT TCATTAAGAG AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC TGT
AACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCACTTG
C CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT TCTTAGTCTA ATAG
ACTAAG GGTCTCTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT
GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TATTGCTGCT AACTAGCTAT GTGAC
CTTAA GCAAGGTATT AACTCTCTCT GAATTTCAGG TTCTTCATCT GTTAAATAGC ATATCTGTAA
AATGGGAATT ATTTTCATAT CATAATGCTG TAGCTTTAAA AAATAAAATA AAATGGATGA GATAAT
CAGA ATTAAAGAGC CTGGGATATA TAGTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT G
CTAATTTTA CAGTTAACCA TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAAT
TTG CCTGTCCTTC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TC
CATCTGGA TGGGTGGGAA ATTTCTAGGC TAGTATTGAG AAGCCCATTT CTTGGGAAAT AGGTCCTG
GA CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTG
GAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTTTA CCTTCTTGTG AAATGGATT
C AAAGATTCAA AGACCTTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG CTGTATGTTC CATG
GAACAC TACTTCCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTT TGGAAACACT
CCATTATGTG GCCACCTCCT TGAAGACTCT AATGCACATT AGCATGTTAA ACAGTCTTGA GAAGT
CCTGC AGAGCAGAAA TTGCTTCACA TCTGCTAAGC CGGCAGTTTC CCAATATACT TGATTATGGA
TAGTTTTTTC CTTACAACAC CATTCTCTGA TATGCTTCCA ATGACATGAA ATAAATATAT ATGCAT
GAGG TTCTTCATTA GGGCATACTT TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA C
AGCATTTAC CTTTTCTGCA TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGTTT GGTTCCC
ACA ATATCTCCAA AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTT TT
TGGTTTCC CAATGTATAT CAAAGTTACA TTTTTACTAT ACCATAGTCT ATTATATATA CAATAGCA
TT ATATCTAAAA AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATTTTCTACC CAG
ACCACTA AAACTTTCTT CATATCAGCA ATAAGGCTGT TTCACTTTCT TACTATTTTT TGTGATAGC
A CTTTTCCTTT CCTTCAAGAA TTTTTCCTTT CTATTCACAA TTTGTTTGAT ACAAGAGGAC TAGA
TTTTAG CTTATCTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT GCTAATGATC ATCTGAGACT
TCAGCAAGTC ATAATCTTTT GCTGGTGGAA GGTCTTGCCT CAGTGTTGAT GTCTGCTGAC TGGGT
GGCTT TGGCAATTTC TTAAAGTAAG ACAACAATCA AGTTTGACAT ATCAATTGAC CCTTCCTGTC
ATAAATGATT TTTTTTTTCT CTGTAGCCTG CAATGCTCTT TGATAGCATT TTACCCACAG TAGAAT
TTTC AAAATTGGAG TCAATCCTTT CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA T
TAGAAATCC CTTGTTGTCA TTTCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCA
AGA AACCACTTTC TTTGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TTTATCCTGA GA
TTGCAACA ATTCAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTC
AT TTGTGCTTAC TTTCTCCGCT GAAGTCTTGA ACCCCTTAAA GTCACTCATG AGGGTTGGAA TCA
ACTTCTT ACAAACTCCT GTTGATGTTG ATATTTTGAC CTGCTCCCAT GATTCATGGG TATTCTTAA
T GGCATCTAGA ATGGTGAACG TTTTCAGAAG GTTTTCAGTT GGCTTTGCCC GGATCCATCA GACG
AATCCC TATCTATGGA AGCTATAGAT TTATAAAATG TATTTCTTTT TTTGTGGGGG CATAGCGTCT
CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGG
GCTCA AGTGATTCTT CCACCTTGGC CTCCCAAAAC ACTGGATTAC AAGCTTGAGC CACTGTGTCT
AGCCCAAAAT GTATATCATA ACTAATGAGG CTTGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTA
CAGA ATGGACGCTG GGTTACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA G
CTCCTGGGT GAGCAGGCCC ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTTTTT TCTGAGC
AGT AGATCTCCAC AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TC
CAAGCTCT GTTTTTCCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA TAATTCTCTA GGGCCTTA
GG ATTTTTGGAA TGGCAAATTG AGCATTGGCT TCAACTTTTT TTTTTTTTTT TTTTTTTGAG ACA
GAGTCTT GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCT
C CTAGGTTCAC ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACC
ATGCCC GGCTAATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA TGTTAGCCAG GATGGTCTCG
ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCA
CAGCG CCCAGCCTGT CTTCAACTTA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC
TGTCCTTTCA AGCTTTGAAG CCAGGCATCA TTCTCTTCTC TAGCTATGAA AATCTTAGAT AGCATC
TTCT CCCAATAGGA AGCCATTTTT TATGCCCTAA AAATCTGTCG TTTGGTGTAG CCACCTTCAT C
ATTGATCTT ACCTAGATCC GCTGGATAAC TTACCACAGT GTCTACATCA TTACTTCTGC TTCACCT
TGC ACTTTTATGT TATGGGGATG GCTCCTTTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TC
ACATTCTT CTTTTACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATGTT GGGCCTTG
GA TTACACTTTG GTTTAAGGGA ATGCTGTGGC TGGTTTGATT TTCTATCCAG AACACTAAAA CTT
TCTTCAT ATCAGCAATA AGACTGTTTC ACTTTCTTAC TATTTTTTGT GATAGCACTT TTCCTTTCC
T TCAAGAATTT TTCCTTTCTA TTCACAATTT GACCGTTTGA TATGAGAGGC CTAGATTTTA GCCA
ATCTCA GTTTACACCA TGCCTTTTTC ACTAAGCTTC ATCATTTTAG CTTTTTATTT AAAGTAAGAT
GTGTGACCCT TCCTTTCATT TGAACACTTA CATGATGATG CCTGGCTTCA AAGCTTGAAA GGACA
GGCAG ACTCTCTTAT TAGGGGCTAA CACAGCTGGC GACTTTTAAG TTGAAGCCAA TGCTCAATTT
GCCATTAGAA GCCATTGTAG GGTTAATTAA TTTGCCTAAT TTTAATATTA TGGTGTCTCA GGGAAT
AAGG AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT T
ATCAATTAA GTTTATCACC TTGAGGGCAC AGGTCATGAT ACTTCAAAAC AATTACAATA ATAAAAT
AAA AAATCATTGA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TG
AGAATTAC CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATA
GA CTTACTTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA GTA
CCATAAA AACAAGGTAT ACCTGTTTAT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCAC
T CCCTAGCTCG GAGACATTCT AACCAACATA CACTTACCTT TCTTTTTGCT GTGTACAGAA TTCA
AATCCC TGTCTCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA
TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG TGTTGCTATA AGCATTAGTT CTTCT
CCAAA GAAAATAGTC CACTTGGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATTTT
TTACAAGAAG ATTCAGTCTC TTACCTACAT AAGCAAAAAT ATGAGATGTT CTCTTATCAT TTTTCC
ATCT ATCTTATAAT CTTTGGTGCT GACTTAGACA CTCATTTTCC TTTTTGTACG TGACCATGTA A
AAGTTCAAG TCAAGAAAAA CTTGTTTTGA CATTTGTTTT GCTGAGTGAT GGGTCCCTAA AAGAAAT
TTG GCTTTGCTTT TGAAAAGTTC AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AG
AACAGTTG TGATGTGTTT AGGTGTTTTA AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTAT
AA AATGAAAGAA TATGAAGGAA AGCCTTCTTG TCTTAGAACA CACTGATTCA CAAATAAGCA GCT
TCTCTCA AAATGTTGTA ATTACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATG
T CTAGAAACTT AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT ATATATATAC AAAT
TGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACTGTTTAA AAGGGAGGGT
ATCCTTGAAA GCTTGACACT TGACTCTTTT GACGAGGCTG AGGGAAAACA CTCAGTTTCA TAGAT
TGCTG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAATT TGGCAATATC TAGCAAAAGT
GCTTATGCAT TTATTCTTTG ACCTAGTAAT CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAA
CAAT AAAAATATAT ATACATTAGG TTATTAGTTA TGGTTTAATT TTTAATAGCA AAATATTTAA A
ACAACCTAC ATGAACAAAT AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCA
ATT CACTTATGTT GTTAATTTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TT
AGTATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAG
GA TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG AAT
TAGGCTT CTTTGAGTAT ATGTTTATAT ATAGTTTTGA CTTTTGAATT ATGTTTATGT TTACATAGT
C AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CTTTAAAATT TAAT
ACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA
TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT ACATTCAGTG GTTATAGTCT AAGGA
CAAGA AAAATTGCAA AAATATCTTG AACTTTAGCT TGTAGGATTT TTATTGGTAG CAATACTAAT
GTACTAATTC TGAAATTAAT GTTCGTGTAT TATAGAATTG AGTAAATGAA TAAATATGTT GATGTT
ATTG GGAACTAAAA TTATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTTGG CAAATGAAAC A
AAGACCTGC AGAGAGATAA CCATATAAAC TCATTATTTT AAAAATTATA AGTGTCCTAG CTCTGTT
ACT GAAAAGGCCT AGATTCAATC TTATCTTGAT AGACAGGAGG GCACCCCTTT CTCAGAACAT GG
TTTCCAAA TGCCATTCTC CATTAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCT
GG ATTAGGTAAA GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA AGAAAGTGCT CAA
AAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA TTTAGGACA
A TCGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT AAAACAAAAA ATAA
TCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC TTATTTACAG ATGAATATCA AATAGCAAAG
ACAGAAGAAA TGACAGAATT AGAGAAACAT CATTTTGCAA AACACCACTG TAATAATCAA TTCAG
GCAAG TATTATTAAT GGATGTATTA CTATTGCGTA AAACCAGTTG GGGAACAGGA TATTCATACA
GTCTGAAGGT GTCACCCTAA ACATAACTTA TTACAAGTGG AAAATGGTGC CTTTACAATG AAGAAA
TCTA GCAGAAACCA TCTTAATCTA GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG T
CATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTATTCTT TTGTATT
CAA CAGACCACCC AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTAATT CA
TTTTGGAT TTTAAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATCTT
TT ATTCAATACT TTAGCTTGGA GAACCATTCA GAGTTTCTAA CTCATTGTAT TGCCAAAAAT AGA
AAACAGC ATGGTTTCTT TTGAAAATGT CTAACTTTAA AGTTACTTGT GTGTGTCACT CAGATTCAC
A TAGCTTTTTT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TTTACAATCT TTTA
TTTAAT ATGACTCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC
AAAGCATAGC AATTTGATTT GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATTACA GGAAT
CATTT ATGAAGCAAA CACTAAAATA TTTATTGTGA AGATTATGAG AACATAGAAG ACAGTTATGA
GAGTAAATTT GAAAACCTGA ACACAAAACT TACATATACT CCAATTGTAA CTTATAAAAA ATACGT
GCAT ATAAGGATAA AACAGTACAA ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC C
TTTTGCTGT CTTAATTTTT TCCTTTTACA TTTTGATACA TTATTTTAAT TTTAATTTTA AAATTCA
AAA GAATTTGCCA CTCATCTTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA TTATTCTGTT CT
TAGTATAG TTTTGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATA
AG ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC ATT
ATGGACT TTTTTTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGG
T GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG CAGACAGTTA GCTG
AGAATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC ACCTTTCCAC CCACGTTTCC
CTGTTCTGTT GTACTCTGCT TACCCTTTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TTGCT
CTTAG TCATTCACTA TGTTGTTTAA TCTGCCTTCC ATCTTTCTTA TCAGTTCAAA TTAGAATGTA
GACCTGAATT TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACATTCT CTGAAC
CTCA GAGAACATTC TTCATTTGTA GAATGGGAAG ATTAATCTAT ATTCCACTTG GATGGCAAGT C
TTTTATAAA CTTTATAACC TAAACATGTG TGAGTTGCTA GTATCATTAT GTTGGTAAAG TTATTCT
GAG ATATGATAAC AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTT AGAGAGTGTG GA
ATTAAAAG GCTTTATCCT CAAATATGAC TTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAAC
AA ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TTTTGTTTAG TCTTTGACAT CCA
CATGGTT AAATCATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT GAAAAGACT
T ATTGAGGAAT AGAAGACTAC ACATTTTTCA GCAAACACTG CACGTTTTGC AGAATTTCCC CAGG
CACCAG TCTCCAGGAA TTTATTGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA
TGGAGATCTT GCAAGTTTTG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGTTGTG AAATA
TTAGT ACAAGTAAAA ATTATTTACA ATGAAAGACA TTTTGTCAAT AGCTATGAGA ATTTTACCAT
TGACCCAGAA ATTCCATTTC TTTCTTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TATTCA
TTAC AGTATCGTTT TTCATAGGAA AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT C
TAGGTCATA GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATGTTT TTAAATTAAC TTGGCTT
GGG TCTTCAGCAA AATTGGCTTC TTAACATTGC ACTCCAGAGT TAGACTTACC CACTCAGTCA CT
TATCATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCA
GG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT GAA
CTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA TCATAATAA
C ACAACGGCTT TGTTTTGTTT TTGTTTTTGT TTTTTGACAC GGAGTTTTGC TCTTGTTGTC CAGG
CTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC TGGGTTCAAG TGATTCTCCT
GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAATTTTG TATTT
TTAGT AGAGACGAGG TTTCTCCACG TTGGCCAGGC TGGTCTCAAA CTCTTAACCT CAGGTGATCC
ACCCGTCTTG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGC
CTTT TGTTTACATC TCTAGTGCAG CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTTCAT C
TTTTTATTT TATACAGCAA TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTG
AAA AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CA
GATATTGA CATCATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTTTTG GAATATAG
AA AATCTGGATT ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG TTC
CACATGT TTCTGAGGCT GTTTGTCCTT ACTTTCTTTT CTGTTTTATC CACTCTTTCT GTTCTTTAG
A TTGGATCATT CCTATTGAGC TGACATCAAG TTAACTGACC TTTTATTTTG TCCAAACTGC TGTT
AAATGC ATCCAGTGAA TTTTTAACTT TATATAGTAT ATCTTTTAGT CCTAGAATTT CCACATGAGT
TTTTTAAGTT TCCATTTCTC TGCTGAGATC TCCTATTTGT TCATTCATTA TGACCATATT TTTCT
CTACA TTATTGAGCA TAATTATAAC AGCTCTTCTA AAATTCTTGT CTGCACATTC TAACACCTGA
ATTATTCTGG GGTCAGTCTC TGTTACATTG CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTG
TTTC TTAATATGCA AAATGATTTT TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA T
TCTGGATTC TCGAGAGAGT ATTGACTTGT TTTTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAAC
TCC AAACTCTAGG TCCTCTGTAA TGGGCAACTG CAGTAATCTT TGTTTAGTTC TTTAAGACTT AT
TGGCCAGG CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACC
TG AGGTCAGGAG TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAA
AAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAAT
C ACTTGAACCT GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT ACTCCAGCCT GGGT
GACAAA AGCGAGACTC CCTCTCAAAA AAAAATTTAT TGGCACTGCT TGGCATCTGC TATGAATACA
TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC ACAGAATTTG GGTCTCCCTT TCTCT
GGATT TCTCCTTTTC TGGATTTCTT TTCTCATTTT CCAGCAGCTG TGGTTGCCCT AAACTCGGTC
CTCTGTTTCT TTACGGCAGT AAGATTTGGG AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAA
AAAA TAATTTTCAT CTTGATGCTA CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT T
GCTTTTTAT TGCTCTCCAG AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAA
AAC TACTCCCCCA AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC TT
CTTTGGAA AAGGATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG TTTTTCTCAT CCGTAATC
TT TTTATTTTCA TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT CAA
ATGACCC CCATATTACT AAATACAATA TCCCCAACTG CATTTATAAA AAGAAAATTT ACTGTTTAT
T AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT TAGA
ATCCCA GATTCTAACT TACTAGCTGG TGTATTAGTC CTTTCTCATG CTGCTAATAA AGACATACCC
CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATTGACTCA CAGTTCAGCA TGGCT
GGGGA GGCCTTAGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA
AGCCCCTTAT AAAACCATCT GATCTTATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTA
ACTG CCCTCACGTT TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC T
ATAATTCAA GATGAGATTT GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTC
AAA TCTCATGTCC TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA AC
TCATTCCA GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTG
CC TATGAGCCTA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC GTT
GGGTAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAG
T CCAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC TTTGACTTCA TGTC
TCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG
GCTTTGCAGG GTATAGCCTG CTTCCTGTTT GCTTTTTCAC AGGCTGACAT TGAGTGTCTG TGGCT
TTTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG
GCTCATGCCT GTAATCCCAG CACTTTGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAG
ACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG T
GGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGA
GGT GGAGCTTGCA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TC
CATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCA
GG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC CCT
AGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA GGCATTTCC
A TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTCTTGA CTCCTGTGCA CCCA
CAGGCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG AACCCTCTGA AGCAATGGCC
TGAGCTGTAC GTTGACACCT TTTAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCTT
CATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA ACCATTTTTC CATCCTAGGC CTCCAGGCCT
GTGATGGGAA GGGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTTT TCCCCATTGT CTTGGT
AACT AACATTCAGC TCCGTGTGCA GCACCAACTT ACTTATGCAA ATTTCTGTCA CTGGTTTGAA T
TTCTCCCCA GAAAACAGGA TTTTTCTTTT CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTTA
TGC TATGCTTCCT GTTGAAGACT TTGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TC
TCTCTCAA GTTCAAAGTT CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAA
GA GTGACCTTTA CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG GAC
TTAGTTG TCCATGTTAC TATCAACATT TTGGTCAAAG CCATTCAACA AGTCTCTATG AAGTTTCAA
A CTTCCCCATG TTTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT CTGTCTGTTA CCCA
GTTCTA AAGTCACTTC TACATTTTTG GGTATCTTTA CAGCAGTGGC ACTCCCCATG GTACTAATTT
ACTGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACTTAC TCGAGACTGG GTAATTTATA AAGAA
CAGAG GTTCAACTGG CTCACAGTTC AGCATGGCTG GGAGGCCTCA GGAAACTTAC AAACATGGTG
GCAGCAAAGA GAAGTTCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAA
TTCA CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC C
CTCCCATGA CAGGTGGGGA TTATGGGAAC TACAATTCAA GATGAGATTT GGGTGGGGAC ACAGCCA
TAC CATGCCAGCT AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTTTCCTAT TT
GTTCAACA AAAATAATGA CACCCCTTTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGC
CT TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT GTA
GACTTTA TTTTTTAGAG TTTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG TTTCCGTAT
A GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTAC
ATTTAT TATAACTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA AAATCCATAG TTTATATTAG
GGATGCCTCT TGGTGTTGTA CCTTCTATGG GTTTTGACAA ATGTATAATG ACATGTATTC ACCAT
TACAG TATCATAAAG AATAGTTTCA CTGTCCTAAA AATCTTTGAT CTTCTTCCTA TTCATCACTC
CCTCCCCATT AATCCCTGAC AACTACTGCT AATTTTCCTG TCTCCATTGT TTTGTCTTTT CCTGAA
TGTC ATATAGTTTA AATATACAGT ATGTAGGATT TTCAAACTGG TTTATTTCAC TTAGTAATAT G
CATTTGATG TTCTTCCATA TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TAATATT
CCA TTGTCTGGAT GTACTACAGT TTATGTATTC ATTCACCTAT CAAAGAACAC CTTGGTTGCT TC
CAAGTTTC AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTTTTTTTGT GAATTGAA
CA TTTTCAGCTT TTTTAGCTCC ATTCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGT
TTAGTGT TGTAAGAAAC TGCCACGCTC TTCCTAACTG GATGTACTGT TTTGCATTCT CACCAGCAA
T GAAAGAGTTC CTGTTGCTCC ACATACTCAC CAGCATTTGG TGTCGTCAAT GTTTTGAGCA ATAG
CATTTT GATCTAACTT TTCCTAGGTA TTCTTTTTGA AGGAAATAAT ATGACAGATA ATAGAGAAAG
GATATACGAG GACAGTTCTG TCCTTTATTT ATAGTCCATC ATTTAATGAA GGACTCTGTC CACAC
TTGGT ATTTTTAACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGTTGCT
GGCACACATG GTTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TTTTTTTTTT TTTTTT
TTTT TTTTTTTGAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG C
TCACTGCAA GCTCCGCCTC CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGAC
TAC AGGCGCCCGC CACCACGCCT GGCTAATTTT TTGTATTTTT AGTAGAGGCG GGGTTTCACT GT
GTTAGCCA GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGG
GA TTACAGGCGT GAGCCACCGC GCCCGGCCTT TTTTTTTTTT TTTTTTTTTT TTTGAGATGG AGT
CTGTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC CATCTTTCA
G GTTCAAGTGA TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATTACAGGT GCCCGCCACC ACAC
CCAGCT ATTTTTTTGT ATTTTTAGTA GAGACGTAGT TTCACCATGT TGGCCAGGCT GGTCTCATTC
CTGACCTTGA GTGATCCACC TGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCATGGGT CATCA
CATGT GGCCTGAAGC ATGACTGTTG CTTTAATCAT ATGAAATACT GCTCTGTATT GTTATCTATT
TGAAATGCCA CACCTCCTGA GCTAAATTGC AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATAT
TAGC ATGATACCAT GACACATATC AAAAGCTGTT ATATATTGTT ACGTGAATTG ATTCTTTCTC A
GTTAAGAGG ACCTCTGTAG TAGCACTTTC ATACCGTTAA TTTTTCATTT TGTGCCCAGC CCCTACT
CTG TGAAAAATGA AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTGTGGACAA TG
TGTGGCTC AAGAGAAAAT TCAGTCAGTA AATTTGTTCA GTGCACAAAC TCTTTATCAC CTCTCACT
GT TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCTTA CAAATTGTCT GGTATATAGT AGG
CACTCAA TAAATGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT ATGGTAGAC
A GATCATTGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA TATGTTACAT TTCA
TGTCAA AAGGGACTTT GCTAATGTGA TTAAGGATTC AGACCCTTGG ATTGTAAGAT TATCCCGGAT
TAACCAGGGC CAATCTAATC ACATGAGACC TTAAAAAAGC AGAAAACATT TCCCAGCTGG GTTAG
AGAGA GATGAGACAG AGTAAAAAGG AAAGAGATTC AGGGCATGAA AATGACTCTA CCCACTGTTG
CTGGCTTTGA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTTAAGAAA TAGGAA
AAAG CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA A
CCACTCAAA TGAGCAAGGA AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAAT
GCC TTGATTTTAG CCAGGTGAGA CCTGTTTCAG ACTTTTGACC TATGGAAATA TAAGATAATA AA
GTTTTATT GTATGCTGCT AAATTTGCGG TAGTTTATTA CTGAAGCAAT GGAAAGCCAA TACAGACA
GA ATATACAGAG AGAAAGAGAA TGAGTTCTTT CCTGATAATT TGTAAATATT TGGGTCTTCA CTG
GACAAGC TTCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCT
T TCTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGG
AAAGAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC
TCTTTCTCAT ATGTCCCAGG CTGACTCTTG TGAGTTGTTT TCCCTTGGAG GCTATCGATG ACAGT
CACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACTTCCAA
GGACTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTT
CCTG AATATATTCC CTATTGTTAG GAAGCCAGGT TGGCTTCCTT GCCTACAATT ATGCCAAGCA G
TCACACTAT AGAGTCCCTA GGGACATGAT ATTAAGTGAT TCTTTTAACA CAAACAACTT AATAATC
ATT TATACTAATA GCAAAACGGC CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA AC
TGGAAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCTG CCTCTGGA
TT CCCCTTTTCC TTATATTACC TCTCAGCACT GGCAGGCCTT TATTTCAGGA TACAGTTTCA CAA
GTATTAT GTCACGTCTC TGAGAATTAT GTTGGTAGAT ATTTGCTCCT CTGGCCAGAA AGACCTAGT
T TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAAT
AGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG
CTTATCTCAC AAGGAACTTG ACAATTTTCT TCAAAAATCC TAGTAGCTAA GATTTCTTAG TAACA
AAGCC ACTAAGGCAC AATTATGATT AACTTGACCC TTAGGTGACT TTTAAGGACT ATTCTATAAA
ATATTACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAATTGACAG TGTCCA
CACT GGTAAAATAA GTTGTTTCAT AAATACATTA GAATTCATTT GCACTTTCTA CACAGCCCCA A
GTCCAGAAC TTTCCCCAGA ATAGGTCTAT GTTTTGCAAT CTGCTACTCC ATACAGAGAT TTGAGTT
CAC TTGGCAATTT AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AA
CATTACTA TACTTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAA
AT CCTTATGTGA ATATGTAGAT AGTCACAATT GCTGGTTGAT GATGATCTGT CTTTTCCTGT ATT
TGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG TGAGAGAGA
G AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTTAGGCAG TAAACACTTT CGTTAATAAA GACG
GAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA CACTCTGAGT
TCCCGGATGT GAGACATCCA GGCGCATTTA TCCAAGAGGC AGTTGGAAGC AACGTTCCGG AGCTT
AGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCATTCTG GAAAACTGTT
TGGCAGTTTC TTAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCC
CAGA TAAATGAAAA AAAAAAAAAG CATTTTTTTT ACACAAAAAC ATATACATGA AAGTTCATAG A
AGTGTTATT CATAAAAAAC TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGG
TGG TCTATCCATA CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA AT
AACACAGA TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATAT
AC TGTACTATTT TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTA
ATGGGTA CTGTGTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACA
A AAGAGCCTTG TGGTTGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGT
GATAAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA
AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTTTCAA TATCAGACTA CAGTTATACA AAACA
TTGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACATTTGGC ATATATTTTT GCAATTTCCT
GTGAATCCGT AATTATTTAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGTTG
ATGA GTTTACCTAG TGGATAGCTT TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT G
CAAGTATAA GCTCAGAGAA CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGG
AAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA AC
AGCTATTC ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCAC
TC TCCAAGAGAG AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC ATG
CTGTGGC TTGCACCTTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT GAGCCCAGG
A GTTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTA
AGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC
TCATTTTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTTTGACCT AGCCTGAACT GTAGC
AAAAG TCATCAGATA TTTTTCCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTTCA
TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGG
CAGG CTCATTTAAA ACTCAACCCA AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC A
AAGGAGCTT GAGTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGT
TCT CTCCCCATTC TTTGATAGGC ATACTTGCTG TTTTCTCACA GCCAAGGTAC AGAGGGGACT TA
GAGGAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCA
TT TTATCAGTTT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGT
ATTTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCTTGT
G TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTG
AAGGTA TTTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG ATTGCTCTTG
ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTTTC CCGGA
GAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA
GCCTAAAGAT TTGCTAGGCA TTATAATCAC ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATAT
ATTG ATACAATGAA TGGTTATAGC AGCCTTATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA T
GTCCTTCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAA
GGA ATAAATGGTT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AA
TGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATG
AG GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA GGT
ATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG AGGGTGATT
G ATATGTTCAT TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATA
CACTTT TAAAATGTTC AGTTTACTGT ATATCTATTA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG
GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATTTTGG AGTTT
AGATT TTAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA TTATGAGTCC
ACAAAAACCA CCAGGAAGTC ATGTATGTTT ATACTTTTAA GTGAAGGATC AGTGGATTAT CAACTC
CCTA ATGCTTTGCC TCTCTATGAC TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC C
CTTGCTTAA ATGTAAGCCT TCTTTCCTCC TTTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTT
TCC TTAAACAGAA TGTACAGCAT ATTATTTGTA CAATTAAAAA TTTTTGGCCA GGTGTGATGA CT
CATGCCTG TAATCCCAGC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG AGTTCGAG
AC CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGT
GTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAG
G TGGAGGTTGC TGTGAGCAGA GATCAGACTA TTGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCG
GTCCCC AAAAAAAAAC ACATTTTTTT TTAATGTTTC CTCCTTGCCT GTAGGAAAAA GGCTCTGACT
CCTTAGCCTG GGCATCAGAG CTCTATCTAA ATGGACTTTA ACCTGATTTT GTGGCACTAA TTCCA
TTGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT TTTTGGAATA ATGTCCTCTC
TCCATCTTGT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTA
CTTC AGCCCACAGA GATATTTAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA C
ATTTACTTA TATATGATCT TGTGATATTT TTTGTTGACG TGTTTACTTT AATTTTCTTC CATAACC
TAT TCATTCAACA AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TA
TATAGATT ATAGATATGT TTGAAATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTG
GT ATATCTGTGA TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT CAG
GAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC ATTAAAAAA
A ATTTTTTTTT TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCT
GCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG
ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TATTTTCTTG TTCTTTTCCT CCTCA
GTTGT CTTCCCTGAA GAAAGGAATG CCTTTTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA
TTTTTGACCA ATTTAATTTA ATCAGATGTC TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGT
GATT AGAGACCAAT TCCCAAACAT GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC A
AGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCT
TTT TATTTTTATT ACTCTATTAG TCACTACAAC TATTTTCTGA TTGCTATGGT GATAGATGGT TT
AAAACAAG CCTTCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGG
TA TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT GAA
GACTCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGT
G GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGG
AAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT
AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAA
GGATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC CTTACCCTAA ATGTAATGAG AAGCTTCTAA
AGAATCTTTC ATTTATTCAT TCATTGAACA AATATTTTGA GGCTTTCTGT GAAGAACATC ATTCTA
AGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC A
GAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT GATTTCAGAC AATGGTA
CGT ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TA
CCTTTGCA TGGTTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATA
CC GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTTTTG GACTGAATAG CAAATACAAA TGC
CCTTGGG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAG
C ACAGAGGAAA ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA GATAATATAG TCTC
TTATAG GTCATAATAA GGCAACCAGA TTTTATTCCA AGAGGATTTA AAAATCACTG GAGGTTTTGC
ACTAGGGTGA GAGGTGTGAT TTGTATTTTT AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGT
AGGAG TAAACTAAGT TAGGGGCTAT TTCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG
GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTT TGGGGGTAGA GTCTATAATA GGTTTG
GTTT ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTTGTA C
CTGAGCAAC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTT
TTG CAAATTAATT TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC AT
TGAAAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCA
AG GCAGACAGAT CAGTTGAGCT CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTC
TCTACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CACTTGGGG
G GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCAC
TGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA
AGGAAATTAA TCTGATCATT GGCAAATGCA TAGTATTTAA AGCCAGGGGA GTAGATGAGA TACTC
AAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATTTAG ATGGTTATAA
GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAG
ATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG G
GCAGTCAAA TAATATAAGG ACAGAAAAGT GACCATTGGA TTTGGAAATA TGATGAGCAC TTTGAGT
GGA GTGTTGAGAC AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AA
CCTGCAAG CACAGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA GACACAGAGT CTTAGCAT
GT CTTGTCTTTC TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT TATTCTGCTT TTT
GTACCTC TACATTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA TTCTTATCG
C CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGG
ATGGAT GGAAGACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA
GAAAGAAGAG TTTAGATTTT TATTCTTTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAG
TCCTT AGATAATTTA TGTAATTGTT CACTTAGGAT TTTTAAATGT GATCACTGAT ATTGGACATG
TTCCTAGTGA AGCATTTTTG GTGTTTCACT GGTTGAAGTT AATAACTGTA AAATTATTTC CCGTTC
AGGA CAGAAAAACA GAAAACTTGA AGCTCCTATT AGAAAGTTCA AGATTCTCTG GGGTTCTTAG G
ATTTACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAA
CAG TGGAAAGACA ATTCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTTCCATA GGAATCAAAC AA
TAGCTTTC AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC TTCCAACCTC ATGGCTGT
TG TACCTTACCT TTCGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAACTT ACCAAGGACT AAC
CAGCCTC TGGGGAATTG CTGTATACTT AGCAAACTTA CAATGGACAT ATTTATAAGC CATAATGAT
A ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCATTTGC AAATGAGTTC CCTT
GCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATTAATCT TTGAAATCCT CCTTTTCCAT
TTTTTGTGTC TTCCTTTTCC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGA
AAAAA AAAGTGATTT GATAAACTGA TTTATATTGT GTCCAAATGT GATTGTATTT TCAAAGATAA
CCTAAGGGGA GAATGCTGTC TGGCCCAACA GCAGGCTCTC GACTTCATTT CAGACACTGT GGCCAA
TGGC TGGGAAACAG GTATGAACAG TAGGTTTCTG AGTCCCCTGG AATTATTCCA TTTATGTAGC C
ACCTCCATG ACAGGAAGCC TCCCTACTCT TACTTCCCAG TTTGTTCATT CATGGCACCA GGTTGCA
GAT TAAAATTTGC TCAGTGACCT TTTATCTAAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AA
GGGACAAA TGCTCATGGT ATACTTTTAG GAGATTGTGG CTCTCTATTA ACAGTATTTA TTCAACAA
AC ATTTATTGAG CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TAT
TATTTCA TTTAATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT CAGAAGAAG
A AACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC TAAGATACAG AACC
AAGAGT CAAAGACATG ATTTTAAACC AAAGCTTTTT CTGCTACTCC ACATTGCTTC CCTAGGTGAG
ATCTGAGGCA TTCCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGCTTAGGAA AAAAA
AGGGA AATGTCCTAA ATAAACAGCT TTCCTATTTA CCAGAAACCA CTAGTTTAAA AATATAATGG
GAAAAATCCT ATTCACTTTA ACAATGTTAA AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAACTT
AACA CATTTGTAGG ATATGTAAAG AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC T
TACATGTAT GGGGAGATAG ACCATCTTAC TGGATTCTAA TATTTAATAG TCTAGGTGTT CCATTTC
TCA CCAAATTAAT GTATACATTT AATACAATGT CAAACGAAAT ATCTTAGGAA TTGCTTACAA AT
TGTCAGAT AATTACAAAG TTTACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACC
AC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATA
CAAAATT CTATTATAAA GGTGTATTGA TGAAAACAAT TTAATACTAG TGTAGCAATA GGCAGCAAA
G CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT TTAAGGTATG ATAA
ACATGA CATAATTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCATTAG
AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTCATCT TACATTAAAA TAAAT
TCCAG ATGTATTACA TTTAAATTTT TTTAAAAAAA GAAACCACAA AATACTTGAA GAAAATATAA
GTTGTTATAT AGTCTTTTGA TGGGAATTTT TTTTTTTTTC AGAGACAGGG TCTTGCTCTG TCACCT
AGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC C
TCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTTA
TTT TTTGTAGAGA CAGGGGTCTT GCTTTGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTCAAG CA
CCTCAGCC TCCCAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATG
AA AAGCTTGTAA AATACTAATT TTTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT TAA
AAAGCAA ACACAAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA CAAAAAGAG
C CTTTACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAA
AGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAGTTTAAC CTTATCAAAG
AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTTTTCCC ACAAATAACC AAAAT
CTGTA AGAATACTGA GCTGCGAATG TTTCAGAAAA AAAAAAAAAT CATACACCTA GTTCGGCATG
TAATTAATAT AGATCAGAAC ACTTTAAAAA TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAA
TCCC AGCACTTTGG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG A
CCAACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTG
GTA ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CA
GTGAGCTG ACATTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAAT
AA TAATAAATAA AAATAAAATA TTTATATACT CTGACCCATC AATTTGTCCA GCATAATTAG GCA
TGTGTAC AAGGGTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA AAAAATTGG
G GAAAATGCTT TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT ATAATCAATA GTAT
ACAGCT ATTATTTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACATT CTGTTAGGAT
ACGCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG TTTCACACCA CTGCTCCTTT GCTAA
TAACC TTCAATGGCT TTTAAAGAAG TAAAAAACAA AGGCAAAATT CCTTAGTCAG CCCTTAAGAC
TCTCTGTTAC TTAGCTCAAA CTACCCTTTT CAACAACACT GCCCTAACCA GGATGAGTTT TTTGCC
CCCC TGGAGTACAT TCAGCCTTTC CTTATCAAAC CTTCCTTTAA ATAAGTATCT TCTCCAGGAC C
ACTTCACTT TCTTCCCCAA TTTAGCATTT TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCT
AAC CACTCAAACC CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATTT AG
GTAAAAAG GTTTTTACTG TTTATTACCT ACTCAATAAA AATTTTCTTT TTTTGAGACA AGGTCTTA
CT CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCTT CTACCTCCCA GCT
CAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACT
A CTTTTCATTT TTTATTTTTT GTGAGATGGA ATCTCACTAT GTTACCCAGG CTGGTCTGCT GATC
TCAATT GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGATTACAG GCATGAGCCA CAATATCTGG
CCCCAGTAAG CTTTTAAGGC CATTAACATG AGGAACAGTG TTCTTTACAC TATTTTATCA GCTAG
GGCTT TGCATGGAGT AGGAGTTTAG TAAATGCGGT TGATGGGTTA ATCAATGTGT GAAAATATTC
AGAGCCACCA AAAACAGATA TTATGTCTAT TCTCATCAAC AATCAAAATT GAGTAAACAG CCATTT
TCTA ATACAGGAAA CCACAAAACA TTGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA C
CAATTTTTT CATCCTGATC CAAGTTAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAATT
TGA GTAGAAGCAT TTCTTATGAA GGCTGTCTTG ACTGGATCAC ATTTTTATTG CTGTTGGAGG TG
CCAAATGT GTGTGTTTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTG
TT ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCTTGCA CTAGGGAAAA GAC
ATATTCC AGGTACAAGT ACTCCCACTT TGATGCTACA GAGGAGTTGC TGAACTTTGT GTCATTAAT
C TCTCTTCGTT AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT GGGTCTTCAC CAAT
TTACTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCCTTT AGATTTAAAC AGGTCTCCGT
TTAAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG ACAGTATGCC TGTCAGTCAT ACTAC
ATTTC CTCAATTCCA TTCATGTGAC TGCTCCATAC CCTTCCCTCT CTCTTCATAC TACTATTATC
TCTTCCCCCC TCCCTCATTT TTAACTGATG ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCA
TCAA AAGAGAGTTT CCACAAACTC CTACTGCCTT ATCTAGCCCT GTACCATATA CTTTGCATTT C
CTCTCATTA CCATGGATGT ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTTCCAC TTCAGTT
TTG AATATTATCA GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC ATTCTCTCTC AT
TTTCTTCC ATCAAGTTTT CCTTTTCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTT
CT TTTTCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCA
TCTCACA CCAGTTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGG
A GAAATAGGAA CACTTTTACA CTGTTGGTGG GACTGTAAAC TAGTTCAACC ATTGTGGAAG ACAG
TGTGGC GATTCCTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC AGCCATCCCA TTACTGGGTA
TATACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGTTTATTG TGGCA
CTACT CACAATAGCA AAGACTTGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATTAAGAA
AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CTTTGT
AGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA C
ACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACA
TCA CCCACTGGGG CCTGTTGTGG GATGAGGGGA GTGGGGAGGG ATAGCATTAG GAGATATACC TA
ATGTTAAA TGATGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACC
TG CACGTTGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAA
ACAACTA AAAATAAATC TTCTTTTTCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTGTTTT
A TGTTGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC AGTTGTCACC TCAG
TTCTCC ACTTCTTTTT GCTGATAAAC TACTCTAACT AGTTACATAT GATTTCTGTC CCCAGGTCCC
CTCCCTCAGT TGTTTTGAAC ATAATCATTT ATATCATTTA TCATTTTCAC TCTAATTGCA CAACC
AAAAA CTCCCTTTTT TTTTAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA
TCTCGGCTCA CTCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAG
CTGG GATTATACAC ATGCACCACC ACACCTGGCT AATTGCTTTG TTTTTGTTTG TGTGTGTGTG T
GTTTTTTTT TTTTTTTGGA CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTC
AGC TCACTGCAAC CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TG
GGACTACA GGCATGCACC ACCATGCCAG GCTAATTTTT TTGTATTTTC AGTAGAGACC AGGTTTCA
CC ATGTTGGTCA GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAA
GTGCTGG GATTACAGAC TTGAGCTACT GCGCCGGGCT ATTTTGTGTT TTTAGTAAAG ACGGGGTTT
C ACCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCA
AAGTGC TGGGATTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCCTTTGT TAATATGACT
GTTGGCCTGC ACATTGTCAA ATCCAGTGGC ATTCATCTTA CTCGGCCAAC CTACGGCATT TGACA
CTGTC TGTCTTTCCT TCTGTTCCTC TATCTGTTTC CAGTATACTG GCCTGGCTTT CTTTTTACCT
CTTTTATATG CTCTTCCAGT CTCAGGCTCC TTTGGGGATT TGAAGGTATG TTGCATTTTG CTATTC
AATG AATAATGACA AGTAATGATC ACTTAAGACA TTAAGTGGTC AGTTCCTTTA CTAGGATAAA A
ATAATTTTC TTCCCAACAT GGGGCATATT CCATTTCCAG TCTGACTGTT CTGTGTAATC TTTGTAT
TCC TTGGCAGCCC CTTTTATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATTTGCAC TG
GTATAACC AAATACAGTT GAACTTTTGG CTTGACTCTT AGCTGAACTC ACCAAAAATA ATTTCTGT
AA GAGACTGAGA CGTCTACGAG TAGGTTTTTC AGAATTAGTA AACATAAATC AAGGATACAC AGG
TAGATTT GAATTTCAGA TAAACAACAA ATACTTTTTT AGTATGTCTA CTGAAATATT TGTATCTTA
T CTGGCAATTC TACCTGGTAC AGAACTAATC CATTCTCTTG AAAGATCTTG ACTCTGTAAT AAGT
TCTTTG GTGATGGAAG GGAGGTATTT CTGTAATTAG AGTCACTGTC TTCCTCCCAG TTTTTTATCC
TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTGCTTTG CAGGA
AAAAA AAATTAAAAA CATCTGAAAA AGCTTTTGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA
GGAGAACTTT CTGTCTGCAC TTTACATCAG AACAACCTTG GCGTCTAGAA GCTGTGCCCT GTGGGA
AGTG GTGGTGCTTG GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC A
GCAAGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAAC
GTC ACGGAGAAAA GGCCAGACTT CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AG
TAAAAAAG CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACC
CC TGCATCATAT GTTTGTTTCT GTTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGGTTTA ACC
CCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAA
C TCAAGTTTCC ACTGATCAGC TTTTCACAAC TCTTATCCTT TCACTAACTT TGGAGCAAGA TTTG
AGAATT GGATGGCTAT TTGAGGGCTA TTTCTGCGCT TTAGTTCAAT GTTTTGTTCT TTCTTTATTA
GAGAACTATG GTTTTTTATT ATATTTACAC TTTAAGTTCT AGGGTACATG TGCACAACGT GCAGA
TTTGT TACACAGGTA TAAATGTGCC ATGTTGGTTT GCTGCACCCA TCAACTCGTC ATTTACATTA
GGTATTTCTC CTAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGT
TCCC CTTCCTGTGT CCAAGTGTTC TGTTTATGTG ATAGATTACG TTTATTGATT TGTGTATGTT G
AACCAGCCT TGCATCACAG TCACTTGCTT ACAAGAAACA AACACTTCAC AGATGGATCA TTATGTG
TGA TAAGTGAAAT CCAAGGATTT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TT
CCTTCAAC CATGAGTGTA TGCAGGTTTT TCTTTTCTTT TTTGAGATGG AGTCTCACTC TTTTACCC
AG GCTGGCGCGC AGTGGTGCGA TCTTGGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA TTC
TCCTGCC TCAGCCTCCC AAGTGGCTGG GATTACAGGC ACCTGCCACT GTCTCCGGCT AATTTTTGT
C TTTTTAGTAG AGATGGGGTT TCACCATCTT GGCCAGCCTT GTCTTGAACT CCTGACCTCA TGAA
TCATCC TTCTCAGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT
TTTTCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTTCCC AATGAAATAT AAAACTAAAG TGCTA
AACTG TGATAGACTG TTTTACAAGA ATGCCAGTTT TCACAAGTGT CTATAGAACA TGTAATTTAG
ATAGGTAAGA TGAAATTTTG ATAATATTTG ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAA
TTCT AAGCCCCTCA ACCAACTGAA TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC T
GAAAAACTA GTTTTGGCCA GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA TTCTCTC
CTC CCTTTGGAAT TCAGGCACAA CTGAATGTCA GCATTGACAC TAAAACACAG ATCTTAAGAC TG
ACAAGCCA GACTCTTTGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTTATTTTAT CCCAAAAA
AT ATTTCTTTGA TATATTTTCA AATGGCCCTG CAAAGCTGTC TCTTGTGGGG AAAATTGACA TGC
TGTACAG AATTTCCTTC TCTTTCCAAG TTTTTACTGA TCCAGGAGAG ATTTAACTAA GAGGCTAGC
A TGTTTTTTTT TTTTTTTTTT TGAGGCGGAG TCTTGCTCTG TTGCCCAGGC TGGAGTGCAG TGGC
GTGATC TCAGCTCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATT CTCCTGCCTC AGCTTCCCGA
GTAGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA TTTTTGTATT TTTTGTAGAG ACAGG
GTTTC ACCATGTTGG CCAGGCTAGT ATTGAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC
CAAAGTGCTG GCATTACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTC
TGAA GCTACTATCT AGAGGCTTCA TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTTATCT T
ATCCTATTA GTTTCTACTG ATTCCAGGTC TTTAGATAAT AACAACTCTT TCAACCAATT GCCAATC
AGA AAGTCTTTGA ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTTATC CCGCCTTTCT GG
ACTGAACC AATGTACACC TTATATGTGT TGATGGATAT CTGCCTGTAA CTTCCATTCC CCTAAAAT
GT ATAACATCAA GCTGTAACCC AACCACCTTG GGCACATGTT TTCAGGAACT CATGAGACTG TGT
TGCAGAC CTTGGTCACT CATATTTGGC TCACAGTAAA CTTCTTTAAA TATTGTATAG AGTTTGGCT
T TTTTCATTGA CACAGGAAAA ATAAAGAATT GGAAGGTCTT TCATCAGTCA CTGAGCCAGC TTCA
TATCTG ACTGAGGTCA TACAGTTCAG TGATTTGTAG CTTTGCTACT TAGATTGCTA TCCATTATCT
AGAAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA CTTTCCTCCT AGAACCCAGG ACCTT
GGAAT ATTCTTGGCA CATAGTAGGT GCTCAATACA TATTGAACTC CTAGGTGCAA TTCATTAATT
CATGAATTAA TGAATTAACA CGCTCTCAAA GTTTAGTGCT TTTTCACAGA CTAGTCTTTC TGCCTC
TTAA GCACTCAGCT CACCACGCTT CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTGCTTA C
ATGTGAGTC TGAGATCAAG TGTTATCTCT TCTGAGAAGT CTTCCCTCAC TGGCCCAAAG GAATTTC
TCC TCTATTTTAG CACTGTCCCA GTTGACTTGT CATTATTCTA GTCTTTTTCA TATTAGTTGT TT
TTCATATA TATGTTATTA AGGAAACTAG TCATTTCCCC TAATAGAACA AAATTGCTGG CCTTTGGG
GT TGGCAATGGA GGGGAGGCTC TTCTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATTTTTCT TAC
GAGATTT ATGTTGCTCA TCTTTAGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC AGAGACCAT
C TGTTCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA GTTT
TCCTAG CTCTTTGATC AACTTTCAAA GTTTTACTTC CATTTGAAAA TTTACTAAGT CACCAGGAGA
TGGTTTATAC TGAGAAATAT CCACTCATAC TCTTCCTCTT CAACTTTCTT CCATATACAC CCTAT
TACAG GGATATAGTC TTACTCTATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT
AAAACATTCT CACCAGAGGT TCACTTGTGT ATTTCCACCC TAGAATGGAA GCTCTACAAA AGCACA
GAAT GTATCATTTT AACTTTAGAT TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT A
ATATTTATT TATCAAGTGA TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAAT
AGT GTTACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ATTTTTTTGC GA
CAGGTTCT CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTGAA
CT TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCA
CCATGTC CAGCTAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT ATGTTGCCCA AGCTGGTCT
T GAACTCCTTG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGA
GCCACC ATGCCTGGCC ATAATCAATA CACTTTTAAG AATGCTAGAA TGTTATATCA GATGCATACT
TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTTATTCTA CATATAAAGT TCAGCAGTGT TGTTC
CACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA
GGGCCTCTCC TTGCACTCTT GCCAACCCTG TTTCTTGATT GTCTCTACCA CCATGAGTCA CCAGCA
ATCT CCCACAGTCA CTTGTTTAAA AGTTCACAAG TATTGTGTGA ATTGCAGGCA ACCCCTTGAC T
CCCTGATTG CCTGGTCTTC TTCCTTGGGC TCTACCATTT TTTTTCCCCA GCACTCTTTC TGCTGCT
CTA AATTTTAATT CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CT
TCCATCCA ATTTTGTTTG TCTGTTTGCT TGCTTGCTTG CTTTAATACA TTTCTCTTTT TCTGAGAA
GG CTTGAGTCCA AAACTCTCAG TTACCTGTTG TTCTGTTTCC CGTTAGTTAA TCTCCGAACC TTC
ATAAATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCA
C ACACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTTT TTATAGGAGA TCCA
GGAGAA ATGAAGTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA CAAGAGTAAA CTTTCTTATA
AGTGGTAATT TTTTTTTACA GGAATAATTG AAAATGGAAA TTACCTTCTC TACTCATAGT AAGTA
CTCAG TGCGTTCTTG ATGGGATGAG AATGTGTTTG AGCTTTAGTG TAAGGCAGAA TTCTGTTTAG
TCTGCCAGTA TTGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGG
TCTC AATTCTTCCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG G
GAGAGTTCT CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGA
GCT CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TT
GGGCTCTG GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCAT
GT GTTACAGTGC ACTCTTTCAG CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTTC TTC
TTGGTAC CCAGGTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA AGGATGAAT
G TGGGAGTTTT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGAT
GGAGTG GGAAGATGAT ATTCTCCTGG AGTTTGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC
CCAGCCTCTC GACGTTCAGA TGCTCCTCTT CTCTCCTTCT CTGCCATGCT GTTCTGCCGT TCATC
TGCCT GTCTCTCTCT GGAGCCTGGA ATTTGGGGTT TATATGGTAC ACAATAAGGG GCATGGCAGG
CCAAAAGGGA ACTTTTTAGG TGCAAAAAAC AGGAATGCCT CTTCTCACTT AGGGCTATAG ATTTTC
AGGC TTGAAGGTGG GGCCTTTACC AGCGAACCTG TATTTCCCTG TCTCCTGTGC ATATCAATGT A
ATCAAATAC TGGGCTGATC CAGGATGTTT CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAG
GTT TTTATATTTG CTTTTGTCAT TTCTTTTTAA GCAATCATGT AAAATATCTA TACGACAGTA AT
AGATGATA GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA ATGATTTCAA CTGTAACT
AA GGTTATTTCT CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTGAAGTAT TTC
AGAAACA CAAAGAGGGA GGTTATATAA ATAATATTTT TTTCCTACTT TGGGAAAATG AAAGCTAGT
C ACAAAGTTAA ACGAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG TATTTCCTGT TAAA
GAAAAT AAAATGCAGA ATATTCAAAA CGTCTGACCA CCCTTCTAAG AAAATGCATC TCTGAGGTAT
TTTTCCTTAG AAGTTATTGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCA
GAGTT TAATCTGTGG AAAGCTTAGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCTCTGAAG
ATTTTTAAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACA
ATTT GCTGTGCCAC TGAGCTGACT GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA C
ACGCATTCT CCCTTTAAAA AAAATGCCCA CACACTGAAT ACTTTTTTCA TGCAATTTAA AATAAGC
GCA CCATCTAGTT TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GA
ATTTTGAG CTCTAGGACA TTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATG
AC AGAATAGAAA TTTCTTTTCC TATTTATCTC TTTGAATAAA ATTTTCAGGA TCTTACAGTG GAC
AAGTTTG TTATCTACAC ATTGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA GATCTGAGA
G GTGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTTTAC TGGT
GGAGAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC
TAACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCA
CAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG GGACAGATTT CAGCAGCCAT CTGACTTCAG
TGCTCATTTT GATGCTTTCC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCT
CACA CAGGAATACT TGCTTCTGTA GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACAG A
TTCTTTCCT TGGCCAAAAT TTAGTTAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG ACTTTTT
GGT AAAATCCAGT TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AG
TCACTATC TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTTAGA
TT AGAATCCTCC TTACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCTTGAC CCA
CCTTGCT CCTCGGCTAT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT CTCCCCACT
A CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC TTAC
CATGCT TTAACAAGTA ACATTGAACC ATTTTTTTCT TTAACAATCT GCTGCACAAT GAGATTACTA
AAACTTTATT CCATTTTGCC ATGCTGGATG TCCTCAATGG AATGGCTCTT GTGAGCACCA AATCA
TTGTG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT GTAACGTGAT GTATGTTACA TGTGATGTAT
GTTACATAGT TTTTTTTCAT GTTGATCACT TTTTGCCCAT TTTCCTATAT CTTATCAGTT GGAAGA
CTGT GGAAGTTTGT AGTACTAAGC CACAAGATGA CTAAGAAGAG TTGAAAGGGC AAGTGGGGCT A
AAAACAGAT TTTGTTTGAC TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAA
GGA GCATCTTTAT CTTTGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTTG GG
GTTTCATG AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTTGA
AC AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC TGA
GACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTCTAC
T TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG AATAGTAAAT ATGT
TTTCTC TTCCTCCTAA TTTTTTAACA CTTTCTTCTC TCTAGCTTAA TTTATTGTTA AGAATACAAT
CTATAATACA TATGACATAC AAAATATGTC TTAGTTGACT GTTTATGTTA TCTGTAAGGC TTCAG
GTCAA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG GAGTCAAAAG GTGTATGTGG ACTTTCAACT
GCAGGGGGGT GGGCACCCCT GCCCCCATGT TGTTCAAGGG TCAACTTTAC TGCCAAAGGC AAGCCT
TTAC ATCCACTTTT TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA A
TCTTTTTTT TTGCAGATCA CAAATTGGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCACTT
TCT TTAGTAATAT TTAAGTTAGA TAATATTTAA GTTATAAAGT TGTTCTTTGT AATCGTTAAT TG
TAATTTTT ACATAGTTTC TTTCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGATGA
TG AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT AGT
AGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC TTGGACTGC
A GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GGTTGCGCTA GTTATGATGG CAAT
TTTAAA TGTGTACTTT TACCCAAAGA AAATCCTTAT TATCAACAAT CACAATGCCA TCATAACCAT
GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CAGAG
TTTCC TTGCTATTCC TCTTTTTCAA ATGACCATTT AGTAAGCACC TGAAGAAAAT ACTATGGACG
GCATTGAAAA GTGAAGATAG GTTTAATCTT CTCGAAAATC TAATTCTCCA GATGAAACGC TGACAC
TTAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACATTTGACA CAGAGAAGTC A
TAACTCAGT CAGCACAGAG ACATTTCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGA
CAT GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTTTAAA GGCAGAACAT AG
CACATATG TGACTGGGTT TTAGAAGCAA ATTTACAAGA CGCACTCTTC TTCATCCTAA ATAATCTG
CA ACCAAAGCTT CCAAAAAAGA CAATTTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGA
TGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTTTCT TCAGGTTCT
G AACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT GAGCAGGACT TCCT
ATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA TAATAATTTC CACTTATACA
TAGGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT AATCTTCAAG GAACTCTGCT AGGGA
TATAA TATTATAAAT CTTGTTTTGC AGATGGAGAA ATTGAATTTT AACCCAAGTT ATCATAACCC
TTAAATGATT AAATGATACT GTTACATGAG AAAGCTGCGT ATCTGTTTCC TGGATTTGTA GCCATA
ATTT GTGTCTCAAG TCCCTTTTGC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TTGGGCTGTT T
GATACCCCC ACATTTATCT TTTTTTTTTC TCTTTTTTTG TTGAGAGAGT CTTTCCCTGT TGCCTAG
GCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC TC
ACGATTCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAA
TT TTGTATTTTT AGTAGACAAG GGGTTTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA CCT
CAGGTGA TCTGCCTGCC TTGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGC
C CCAAATTTAT CTTTAATGCC CCAAATTATC TAGTTCCCAT GACTGGGCTT CTGCTTTGAT CCTT
TCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA TTGTGTCCTG AGCCCCTAGT TAGAGGCTAT
GTCTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC ATTAAAAGTC TAATTCTCTT GGAGA
ATTGA GAGATACCTA TTTGTCTCAA AATCATTGAA ACCAATTAAT GTATTATGAG CCTCTATCCA
GTGATTTGTA CCTCAATTCC CCAATCCAGC TGTCAAGGCC AATTTGTTCT ACCTTACCTA GTAGGT
AAGT CTGGAATTGT AGCTGTGGCA TTTTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCTT T
TTGGCACCA GGGACCAGTT TTGTGGAAGA CAATTTTTCC ATGAAGGGCT GGGCAGGGGA GTGGTTT
CAG GATGAAACTG TTCCACCTCA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT AG
ATCCCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATC
TG ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTTGCCTAC CGCTCACCTC CTGCCGTGCA GCT
CAGTTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGTTGCTAG
G TATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG TATCTGATGA GATA
TAAATT ATTTGATTAT AAATTACTTT CTTCATATTA GAGTTGTGAA TGAGTATCAC ATATAATTAT
ACATAAACTA GGAATATGCT TTTTAATAAT GTATATAAGT AAGTTTCCTT AACTATGACT TTCAT
CTTAG CGTAGTAAGA GGGTGCTAAG AAATATTTGT GATGAAAATA GGCATTGGTA GAGTTGAGAC
CACTGGGTGA TGAAAGAGTG TAAAGATTTT AAAGCCTTCA GATGCTGGTT CAAGGTGAGA AATGTG
ATTG GGAGCAAATC AATTAACTTC TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAAC A
TATGTAAAG CTCTTCTGCC CTGTATACAG TAAATGCTAG TTAGCTATTA TGATCACTAC TAAAATG
GGG ATGACATAAA CCTCATAAGG TTTTAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TA
TCACATTC AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA GAGAGAAAAA AATGCTGT
CA GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA TTT
TTGCATT TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTATTT AACAACTGGT AAGTCTATA
C TCCCCCAAAT CTGGAATTCT CCTTTCTTAT TCTTTTTCCT CCTACCAAGA CCGCAGGATC TTTT
ACTTGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT TACTTTTATA CTCTGTCACA
GATTCCCTTT GTTTCCTCAT CTCCATGTGA ATTTAGTTAA ATTCTCAGCA TTCTGATCCT TACTA
TACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTATTTACA TAAGGCCCCA
ACCTAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACA
GACT TGAGAGAAGA AATGGCAGGA TTTCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAAA A
GGTCAAATA GAATGAAGAT GGAGAATACC GGATTTTCTT ACAAAATGAT TTCCCAGGAG ATCTCAT
CAA ATGCACGAGG ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TT
ACAATTTG GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGA
AA TCAAACACTC AAATTTTTGG TCCTTCTGTT TATTTCATTT TGGATACTCA GTGAATGTTA ATT
AACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA TTTTGAGTA
T TCTGGTCTTA AAAACATCTC TTTCTTCTAC AAACTTCTGA AAGAGATGAA CACCTCCACC TACA
CCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCATTTTTAC TTAACAGTCT AAGGAAAGTC
TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT CTGAGGTGAG AATGAGATCA TATTT
TACAA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC AAAACTCAGA CCACTCACCA GAAAAAAATC
GGCATTTATA TAGTTGTGTT ACTTTTGGTT TCCTGCATCT TTTCACATCT GGCTCATTTA CATCAT
TTTC TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT A
CTGTTATAA TCTTGAAAGT GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCT
GAT CCACAACCAA GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GC
CAGGAGGT CAAAGGTACA TTCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGA
GT GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG TTT
TCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT CTAACATCT
T CTTTAAATCT TTAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT GTTTTCCATG TGGC
TCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCATTT
TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TTTCT
GTCCC TCTCTTCTCC TTTTTGACTT TCTGAGACTG ACAGCTCTTT TGAGGAATCC AGGGTCAAAG
CTCCATCTCT AATGGGTGTT AATTCATTTT CCAGATGGTC TTCTATAGTG AAATTAAACT GAAAGG
TCAT CCTCTTATTA AATGCACACA ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTTG A
TGATACACA CAAATCTGCC TCAATTATTC AATTAGTTTT GTTGGGCCCA ATTTCTCTTT AGCAGCT
TAT ACATGGTAAC AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TTGGTCCTCT TT
CCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCAC
AT TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTT
TTTCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA CCTTAAGGG
T TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCAC
TACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTCTTTC
AGCTGTCTTG ATTTGTGTCC AACCATATTC ACCCCCTAAG CTTCCAGAAT AACTTCACTT CTGTC
TTTTA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA GTCAGCGTCC CTTTAAAAAC ATGCATAGGT
ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CTTCACTCCA AACATTTAGT CGAGAACAGC AGCCCT
AAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA C
GCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTTATT GAGAATC
TTC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATTTT CACAGTTCTG GCAAGTGGGA TC
TTTGTTCC CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGA
AC GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC GGA
ACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA TGTTTACAG
T GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT CTGAAAAAGC TCAC
CTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG
CCCGACTTTC TTTCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTAT
GGTTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTTCCGGT CTGGGCTTTG
GCGGGTCTGG TTTGAAGCTC TCCTGTTTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAG
CGCG GTTCCCCTGG AAGAATTAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC G
TCCTGCCCC GACTCCTCAT ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGT
CGC GAACCTTTCT CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCGGCCT GA
ACCCCCTC TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGT
GG TAGATTTAAG TAAGGCTTTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT TAG
CAGTGGA TGTGGCGTTT TCTTCCATTC CTTCTTTCAG TTTTTCTGTA CTCGTTGCTT GCAATTAAG
T GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGC
TCTGGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCTTTT GTCTCCCGTA AAAAGGGTGG
TGAATATGAA TAAGGGCTTT CTTAGCGTTA TAAGAATTAA AGGGCATAGT TCTGTGGTGT GAAAT
CTTTA AAAGATGTTC AGTAAATAAA AATGATTTTC CTCCTTCCCC TCTCAGACCT CTTTTTCTTC
TTTCTTTCTT TTTTTTTGAC AAGTTCTCAC TCCTCTCACC CAGGCTGGAG TCTTTCTGAA AGAGTT
CTTC CGCTTGTTGT TGGCTTTCAA CTGTTGGATT TGAGGCGCTT AGCGCCTTCT TCGTCCGGGT G
CAGCACATT CTTGATTGGT CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CTTTCAT
GGT AAACCATATG TATATGTATC TTTTTCACAA CATTTGAGCC CAGCTTTATA CAATTACACT CA
AAAGAAAA AAAGTAACCT TCACTTGAGA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAAGCC
CT ATGTAATCAC ATAGAAGTCA TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC CCC
CTTTTTT AGTTTTTGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTT TCAACTTGAA AACAAATAG
C CACCCTCAAA ACATTCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGG
CTTTGG GAGAACAGAG ACACGGAACG TGATTCCTCT TCTTCCCCAC AAGCTTATAG AGAGACTTCA
TTAAGTTGAA AGTCAACATT CCCACCTAGC TTTGCACTTC AAACGACATA TTCAAAAAAG CCCAA
ACTTC CTCTAGTTTT CTTCATCTGA GTAAATGGTT TCACAAACTG AAACCTTGAA TCCTCTCTGT
CTCACACACC CGATCAGTAA GTTCTATTGT TTCTGATTCC AAACTATGTC TTGAATCAAT CCGTTT
ATCT CCATCCTCAT TGCTACCACT CTGATTCCAA ACCCTTATCA CCTCTCACTT GGAGTATTAA T
AGTTTCCTT GTTTCTACTC ATAATTCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTC
GTC ATTTCCCTTT TTAAACCACT TTACCTTCAA GGTTCCAGGT GATCTAAGCC TTGCCCTTCT CT
CATACCTA GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATCTTTT
TG CTCAGCCTGA TTTGTTCTCT CAGCCTTTTG CATATTTCAT GTTTATGTCT TGGCCCAAAT GTC
ACTTCCT TAGAGGGGCT TTTTCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA GTCTTACAC
T TGTATCACAT TGGCCTGTTC AGTTTTCTAA AAAGCACATT ACCATTAAAA GAAATGCTCT TGTT
TGCTTT GTATATTTTC CACTTCTACA CATTATGTTG CAAAGTTCAT AAAGGCAGGA TGTTGATTTT
CTTCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC ACATAGTAAG CATTCATTAA AGGGC
TAAAA ATATTTCATG TTTTAAAAAT ACTTGGGAGT CTAATTAGAC AATACTTTTT TTCAGCTTAA
TGGTAGTATT TTAGCTTCAC TATTTTAACA AATGAAAAAT TTGCAATAAA TCTACAATGC CATTAC
CCCC CAAAATCTTT TTCATGTTTT GCATTTTACG TATTATTTTC CAGGCCTTAC CTGCATGTCT G
CATAATCAT AACTGACTAA TTTTGGAACA GCTGGTAATT ATTTGAGCTT TACTGAAATT TTTTCAT
GAG GCCAATTCTA CCCTACTGAA CTCAAATTTG AGTTAATGAT GACCTCATTT TGATTGCTGC TG
TAAAAAAT AAGATTTCGG AAGAGGAATG AATTCTTGTA TTACTGTGGT AGGACTATGG GTTTTTTT
TT GTTTGTTTGT TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT GCG
ATCTCAG CTCACAGCAG CCAGGTTCAA GTGATTCTCC TTCCTCAGCC TCCCGAGTAG CTGAGATTA
C AGGCACGTGC CACCATGCCC GGCTAATTTT TTGTATCTTT AGTAGAGATG GTTTCACCAT GTTG
GCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TGCTGGGACT
ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TATTCATTTT TCTTATTAAC ATTCTTTGAT GATTC
TTATG GTGTTGTTAC AGTAAAACAT TTCTAACAAT TATTCTAACA ATTATTCTTG ATGGTGTATA
TGAAGAATTT ATTGTCGTGT ATTTGTAAGC TGCTATGTGC AGAAGAATTT CAGTCAAATA AAGTTG
GTAA GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAATT A
AGTACAATA GAAATGTTGA GGAAAGAAAA ATTTCTTGTA ATAGAAATCG GAAGTACAAA CTGGGCA
TGG TGGTGTGCAT CTCTAATCCC AGCTCCTTGA GAGGCTGGTA TGGGAGGATC ACTTTAGCCC AG
GAGCTTGA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGT
CT CTCTTTTTTT TTTTTTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT TGG
CTCACTG CAACCTCTGC CTCCCAGTTT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG CAGCTGGGA
T TACAGGTGTG CGCCACCATG CCCAGCTAAT TATTTTGTAT TTTAAGTAGA GACGGGTTCT CACC
ATACTG GCCAGGCTGG TCTTCAACTC CTGACCTCTT GTTCGCCCAT CTAGGTCTCC CAAAGTGCTG
GGATTACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TAAAT
AAATA AATCATAAAC CTGTGGATTA TTGTAGCATT GTTTCTCATC TGTCAAAAAT ATTTCATGAC
TATGCATAGT TTGAAAAGGC AAGTTTGTCC CTGGGCAATT TTCAAAATAT TTCTTTAATG TGTTTT
CACA ATACTGTTTA CCTAATAAAT CTTAAGTTTT TAAAAGCAAA ATTAAGCCAG TAATTTGAGT C
CAATTCCAA TCTCTTATGA GTCATTGCTT AAATTTCAAA AGGGTTTTAT TTTTTTTTTA GGTTTGT
TCT GAGTAATGAA TACCCTATTA CTATGATACT AGTATCTTCC TTAATTATCC TACTCATTGT CT
CAACATTC TGACAGTTGG ATTGAGCATA TTCGTAAGTA AAATTGTTTT AACTGTATGA TGTACTTT
GA TGTTAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGTT CTTACAGTTT TGTATTCCCT TGA
AATGTAA CTGTTCTCTA TGTTACAGCC TTTATAACCT TCAGTTACTT GAAATGAACA AATTCATTC
A AATTCCAGCA CTTAAAAGTT TTAAATTACA TTTTGGATAA ATACCAAAGT GTTTTGTTGA TGAT
GTATGT ATAAACAAAT TGTAAATATT AAACGTTAGT TGTTACGATT AGACCTATAT AAAACATGAT
ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGTTTA GTGTCATTTA GAAAATGCTT TCTAA
ATTGC CAAAAGCTGA TTGTCTAGGT GATAACAAAT TTACCATTTG GAGGAAGTTG ACTTTCTCAT
TTTCATGTCT TCATCAGTCT TACTTGATGA GATTCATTCT TCTAGTCAGA AGAGAGTTTA GACTGC
TCAG TTTACTCATA TTTTGAGTTA GCTTTTCTAT TTAGAGTTCA CTTGGTTGTG GAATATTCAT T
TATAATTTG AATCTACGTT GTGTAATGGG ACCTAATTTT TTTTTCCTTT GTTTTTGTTG GAGTCTC
GTT TTGTCACCCA GGTTGGAGTG CAGTGGCGTG ATCTTTGCTC ACTGCAACCT CCACCTTCCA GG
TTCAGGTG ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGCCTG
GC TAATTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCATGT TGGCCAGGCT GGTCTCAAAA CTC
CTGAGCT CAAGTGATCC TCCTGCCTTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGCTGA
G CCTGGCCCCA GAGTTTGTTT TGTTTTGTTT TCAAGACAAG ATCTCACTCT ATTGCCCAGG CTGG
AGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTATT CTCCTGCCTC
CATCTTCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT GCTTGGCCTG TGTTTTTGTT TGTTT
GTTTT GGGGGACAGG GTCTTGCTTT GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTAGC
TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGAC
CGCA GGTGCGTGCT ACCATGCGTG GCTAATTTTC TATTTATATA TTTATTTTTT GGTAGACATG A
GGTCTTGTC ATGTTTCCCA GGTGGTCTTT AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCAC
CCA AAGTGTTGGG ATTACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTTTTT AAGTAAATTA TT
TTTTTATC TTGAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAACAG
AA AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATTTTG ATGAGAACAG TCTCATCTCA TTT
CCGTATA TTCCTGCCAG CCTATCCATC ATTCTTCGTA CATGTTTATC TACATTAAAA TTGGTGTTA
T ATTTTGGAAA CTTTTTGTTT AACTACATTG TGAACATTTT TCATGTTTTA AAATGTCATT TTAA
TGATGG CAGATCCTAT TCAATAGATG TACACACACC TATTTAACTG GTCCACAATT GTTGGATATG
TAGGTCGTTT CCTTTCTCTC TTTTTTTTTT TTTTTGGCTA CTACTTAATA GTTTCTCTGT ATAGA
ATGTG GTATTTTGAA AGTGTATCAA GCTTTAGATT GGTAGTATTC TTGCATTTAA TAAAGGGCAG
TGGCCTTTGT TGACTGACAT GACAATATTT TTATAAAATT TGTTATTTGC TTTACAGAAA TTTTGA
AAAT TATTGTAGAA ATGTTTTTAC CTCATATGAA CCACCTGACA TTGGAACAGA CTTTCTTTTC A
CAAGTGTTA CCAAAGGTAT AATACTATTA CCTGAAAATA CATGTTATAA GGAATCTAGC CTCAGTC
TTA GATGATTTAT TATTAATTAT GGCTCTCTTT TTCTAATATA TCAAATATAT TCAAAATAAA AA
TAAGGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATTAGGCAG TTAAAAAC
TG TTACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG GCA
GATCATC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACTAAA
A GTACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT GAGA
CAGGAG AATTGCTTGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA GATCGTGCCA TTGCACTCCA
GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACTTAT ATTTT
CAGAT TGTGTGGTTC CTTTACTAAC TGAATTTAAA TTATTTGTAG TCAATTTTAA ATGCTCTTGT
ATTTTAAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAA
AAAA AAGAAAAGCT GGAATATTGG CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGAA T
ACATTATTA CATTTTAGAT ATATATGGTA TATGTTTTCT CTGAAAAGCA CAAGCATACC TTTTTTG
TTT TAAATGGAGG GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG TAATTAATCT CT
TATTGAAA TGGGTTTCTA ACTTTAGCTT TGAATCGTAA TCTTTCAAAT TTCTTGTACT CATAGTCA
CT TGATGATTCT CTATCTGAAA TATTTCTTAG AATTTGTTCT TGACCACCAG AAAAAGATTC AAC
TGTTACA TAGATGAAAA TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT TCTTTAGCT
A CATTGTATTG TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCATTTAA ATTGTTAGAA AGAT
CCAAGT ATTAAGATCT AGGGTGGCTA ACTTTTCACA GACAAAAAGC TTGTTTGTAA GGTCATTTAC
TATACCCTTA ATTCAGGAAG GTTAGCTTGA ATTGGGTCAA AAGGAAACTG GTTAGAAAAT AAGTG
AGTAG TGAATAGGCG ATTCAGTGCA AATTCCTTCC AGAAAATACC CTTGTAAATG ACTGTATGAA
TGTGGATTCT TCAAGACAGT CAAATTTATT GTGCGAAAGT AATACTTTTA TTTTTTGCAT CTCTAA
AACA TGAACTTTGA GTGATTTTTT AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAAA T
GGAAAATAA ATTTCTGTTT GGGGCTTTTG GGGGGATTAT GTTGTAAAAA TACCTTTTCT CTGTATT
TTG TGCTTAATTA GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATGTTAC TAGTGCAAAA TC
AAATTATC GTATTGTGTT TTCTCTGTAA AGTTTTGTCT TGTCTTTTCT AGTGATTTCT CTTATTCC
TG TTTATTACTT GATTTGTTTT TACAGACTGT GAAATTATTC GATGACATGA TGTATGAATT AAC
CAGTCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA ATCCAGACCA CTCTAAGGAA TATTTTACA
A GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAATTTTT ATAC
TGATAC TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA ATTAAATTTA TAGAATTAAA
GACGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AGCTA
GCTGA CCCTACCTGT ATTTTCAAGG ATATGTGTGG AACACCTGCC ATGTGTTTTG AAGTTTGTGT
TAGTATTCTA AATGGCTAGA CAGTTGTTCC AGTATTTGTA GTTCTGATAG ACTAAAGTTC TGTGAA
AAGA GGAAGAGACT GTGTTTTGTT CATTGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATACC T
TTTCAGTGC ACAAAAAATA TATTCTAAGT GAAATTTCCT TCCTTATTCA CAGACAATGG TGCAGCT
CTT AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATTTTGGA AA
ATATTCAG AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCATTG TAAGGTGA
GT AAAGGTCTAA TTATACTTTG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA ATG
TTTGTAT AAGATTTTAC ATTTTAGTCT ATATTATTGA AATAAACTTT TCCATAGAAT AAAGAACAT
G TAAGTAAATA ATTGTTGCAA AAAAAGTGGT TTTAAGGAAG TCATTAAAAG TGGCTTTTTG GGGT
TTTTTA GTTTTATCTT ATTTCCCCTC TATAAAGAAA GAAGTTTTAA GAATTTGTGT TGAGACAGAC
ACAGGGATCC TGAAATAGTT ATGTCATGTT GCATTGACCA ATATTCAATT ACCATTATGA TTAGA
TGTCA GAACTTCCTT TTATAAAGGA AAGTTAATCC TTATTTAGTC CATCTCTACA TGCCAGAGGT
AGCCTTGAGG CACAAAAGCT TGCCTAGAAT TTATGGGTCA CAGACAGTTT TAATATTGCT ATTTGT
TGGG CGAATGAAAA TCACTAGTTA ATTAATACCT CTCTTTGCTG ATAGGATGCT AAAAATGTCA C
GCACCTGGC CTAATGTTAC CCTTTTTTAG TTCTGTATTT GCAAGATCAT GGAAGTCAGA AATAATA
TTT TATACATGCT TGCATCTCTT GAAGCACACT ATATTTAATG GATGTTCACT AAACAATGAA TG
AATATGTG ATTCAGTAAA TTTATGATCT CTAATAGTAT GAATTAAAGT AAATTTGGCT CTTGAGCT
TT GATTTGTTTT TTCTCTCATT TTTATTTATC CGTAATCAGA ATAGTGAATC TGTGTATTCT GGG
TGTTTAC ACCTAGTTTC AGACCTTCTC CAGGCTCTTT TCAAGGAGGC CTATTCTCTT CAAAAGCAG
T TAATGGAACT GCTGGACATG GTTTGCATGG ACCCTTTAGT AGATGACAAT GATGATATTT TGAA
TATGGT AATAGGTGAG TGAAGAAAAC TTTCTGCTTA GTATATGGTG ACTATAAATC ATGTATCAAT
TAAAATTGTC TCTAATGATT CATGTTATTT TCTTACTAAT TATGCATTAA AATTGATTTA AATCT
TACCA AATAAATTTT TAATCTTGAA ATTTGGAATT TGTAAAATTT ATTTTGGGTA CCTTAACCTA
GATTTGCGTA TTTAGTTACT GTAATTTCTC CACAATGATT AACTTATATA ACTTTATAAT CTCTGA
GGTT GTCCATATTC AGAGACAATA ACTTTCACAT TTTTTTAACC ATAACTGATA TTGAGATGCA G
TTTATATTT CCTTCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCAT
ATA CATATTATAA TGAAATAACT CATTTTACAT GTGATGCACT TTATACTAGT TTATTTTTAT TT
TATTTTAT TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCG
GC TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT GGG
ATTATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TATTTTTAGT AGAGACAGGG TTTCACCGT
G TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA GCCTCCCAAA GTGC
TGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGTTTAT TTTTAAAGAA TTGCTGGTCG
TAACACACTT CATTGATTTT ATCACTCATT AATGGATTAT GAACAAGAGT TTGAAAAACA ATATA
AAGGC AAAGTTTGCA TTCAAAACTT TGGTATAAAG AGAGTAAGTT GGTTTTGTGC AGTGTATCAG
GCACCTGTTG CTCTGCAACA CACCACCTCA AAATCTATTT ATTCACTATT TATTTATTCA TGATTC
TGTG AGTCTGCAGT TTAGGGTGGG ATGTCCTGAG ACAACTTTCT CTGATCCACC TGGGGCACTA G
CTCACCCAT GTGACTTCAG TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTTGAGA
AAG CCATGTGCAT CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGGTTTCAGG GT
TTCTAAGA GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG CTAGCACTTT TCAAGTTTCT GCTTGCCT
TA ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCATTGTAG AAA
AGTGTGG ATTCACAAAG GGCAGTCATT GTGGCCATTT TTATAAATAA TCTACCACAG ACTGAGTAA
A AGCCTTGCAT GAATACCATG GATATTAATT TGAATTCTTC CTTTTTAGAT TTTCTTTCCT TAGC
AATTTG TTTTGTCATT TTGGATTAGA ATTATATCTG TAGAATATTT CAGTTATAAT AGGGTACAAC
TTTTATTCCA CTGAACATCT TTAGTTTTAT TTAGGTCATC TGGTAGGTAT AAACTTCAGA AGTTA
ATATT CAATATTTAT AAAAACCATT AACAAGTGTG ACACTTAAAT AGTTTAAATA ATTCTTTTGA
CACAACTGTT TCCAAGTTGT GTTACGTATT TTAATTCAAT CAAATGTTGA AATTGTTCAG TAGATA
GTTT TAATTATAGG AGAAACTCAC CCCCATGACA TTTGGATGTC TTAAAAGTTC TGTTATCTTT C
TTTGCAGTT ATTCATTCTT TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC ATTTCAT
GCC AATACTTGGA AGTTTATAAT TAAGTAAGTT TGTTTGTTAT TTTTTACTTT TTAGAAAATG TT
TTCCATAT TCCCCAATCT TAATTATTCA TGATTCTTTA GATTGCATTT AAAACATTTT GTGTGAAT
TT AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA ATT
GGACTTC TTTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC TAGTTAGCTA GTACTTCAG
A AATAATGGGC CATGGGCCAG ACTAGAACTT AACCACTTTT CTTCTGCTAC TGTTGTTTAA CCAG
CTATCA AGTATCCTAT TTCTAGGATT AGATAAATTG ATAACTATAA TTAAAACTGA ATATAATCTT
TTCATTAGGT ACTTTTAAGT TGTTCACACT TAATTCCATT TGTACAGTAA TTTTAACTTT CTGAA
ACTGA AGCATTTTAA AGGGTCACCA GGGATAGTGC CTGTAGCATT CATCAGATTC TTAGGGGTGA
GAGGAGATGT GGTTGAGATG TAAAAATGGT TAAGAATATC TACTTTATAC ACATACATAA AACATT
AAAG GTCAGTGTAT TTTCAGGTCT TAGGTACTTT TCTTGTACTA CCAGGACATT AAGTTGCCAT T
CAGTGGTTA AGAGTGTTGC CTGGGAGCTG TATCACATGT GCTTAAATCC ATTCTTGAAA TCATTTA
CTC CTTCTGAGCC CTTGGGCTAT TTGGTTAATT TCTCTGAACG TTAGTTTGCT CATCTGAAAA TG
GAAATAAT AATAGCAACT TCTTGACAGG GTTATAGTGA GAATTGAGTT CATCACTGTG AAATGCTT
AG AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT GAT
TATCTTC CACTCTTACC CTCTTCCAGT TCATTTTCTG CCCAGCAGAA TGATCTTTTA AAAAGTAAA
T CAGATCATGT TACTCTATTG CTTGAAGTCT ATCCCATTTG ATTAAGAATA ACAACCTAAT CCTC
TGTGGA TGCTGCCTCC TTCACCAGCC TGTCTCATGC TGCTCTCCCT ACTCTTAGTT CCTCAAACAT
ACCAAACTCT CCTGTCCCAG AGTCTTTTCG TGGTTTTTCC ATCTGCCTAG GATGCTTCTC TCTCC
TATTT TGTGTACCTT GCTAACTCCT GCTTACTGTC TTTCAGTTCT CAGCTTAAGA GTTATATCTT
CATGATAACA TTCTTTGATA TCCTTACCCT AAGATTAAGT TAGATTGATA TCCTTACCCT AAGAAT
AAGT TAGATTAGGT CTCTCTATTG TAGCACCTTA GACTCTGTCA TTTGACAAAT CACAGCCCTA A
TTAATTATT CTTAAAATTA TTTAACATTC TCTCTCATGC TAGACCACAA GTTTCATGCA GGTAAGG
CGG AGATTGTGTC CATTTGTTTG ACCCCTTTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AG
TAAGAATT CAATTAATAT TTTACACAGA GAAAAAATTA GCAACTTATT TAAACAAATA TAACTGCT
TC AGAGGTAAAC TGGGCACATC TTAGTTATAT TATGTGATAT ATGATGCTTT TTGATTGTTT TTT
TAAATGT TCTACAAGGT AGATATTGTT AGAGGTCCTA AGTTACTTGA TGTGTTACTT GTGGTGATT
G TATTCTTTTC TTTTTATTCA TTTAGGCAGA GCCTTAAGCA CCAGTCCATA ATAAAAAGCC AGTT
GAAACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTTTTC TCCTTCCATT CTTGTTTACA
GTTAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA TTTGGGCTAA TAGCATTTTA AACAG
CAACT CTTATTTTCT TTGGCAGTTA GTAAATCTCA TTTGAATGTC TGGGTCAGTC TATTTAAGAG
GATTTTAATT TATTTCATTT GGGTGTTTTT TTTTGATCTG TGGGATTATT TATATCCCAT AATTAC
TTTT CACCCAGAGC ATTGTATTAG ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT C
CCTCTTTGC TTGGTAACTG GTTGGTCACA GCATTCTTCT CAGAATCCTT TCATTCTTTT CTGCATG
AGA ACAAAAATTC TTTTGTTCAT ATTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT TT
TTTCTTCA CCAACGCATT GCGACCTTTA GGGATACAAG TATGTTTGTG CATGTATATG TATGTATC
AG TCTTTTAAAT TTGATATAGT CATACATTTG TTTTTATTTT GAAAAGTTAG AGTGTTGAAT TGG
TATCCCA TTTATGAAAC ATTATATTCT AAAAATTTGT AGTACGATTA TTGGGAATTA TAACTCATT
T TCCTGTAACA CTGTTATACA TAGTACCTTT TGCTTTCAGA CTAGCCCTCA ATTTTATTTA ACTA
TAGTAG TCCTAAATTA TAAGATTAAT AGTACTCAGG ACCTAACAGT TATATGTCAT TTGTTTTTTT
TTTTTTTGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA GTGCAGTGGT ATGACCTTGG CTCAC
TGCAG CCTCTGCCTC ACGGGTTCAA GGGATCGTTC TGCCTTAGCC TCCTGAGTAG CTGGGATTAT
AGGCGCCTGC CACCACGCCT GGCTAATTTT TTTAGTAGAG ACGGGGTTTC GCCATGTTGG CCAGGC
TGGT CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCTTGGCCT CCCAAAGTGC TGGGATTACA G
GTGTGAGCC ACCGCGCCCA GCCTATATGT AATAATTTTA ATGGGACCAT GAATTGAATA TTTCTTC
CTT GAATAGCAAT GACATAGCCC CTTCTATTGT ACATCTGCAA GCTGATACAG GGAATTCCTT TG
TACCTGCG CTCTTCCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GTCCTAAA
AC TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC TTT
AAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTTA GGAAGGGGCT AACTTTTTT
C TTCTTGCTTC TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TATCCCTTCT TCCTTTTTCC CTTT
CCTTTT TTGTCCTCAC TTCATTCGTG CATCCTTTCT GATTCCTCTT ACCTTGCTAA AAGGAGAAGT
TTGTTTGGGT ATCCTATATC AATGGCAGGA AGGTTGTTTT CTTCTTTACC TTTATCCTAT AGATT
CATAT TCTCAACACC AACCTCCTCC TTTTTCAGTT TCCTTCTTGC TTCTCTTGAC ACCACAGAGT
TTGCAGCTAG TACTTGGAGA GGAAAATTAA ACAGAGATAC TTGGACCAAG AGTAAGATGA AGAAAG
TCTA AACAACAGTA TAGTCTATAG TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT G
TACATAAAG TATATCTTCA GTTTATATAA ACTGCTTATA GATGGAAATC AGAAAATTTA AATTCTC
TTA ACTGTCCAAG AAAATTCTCA TTTTTTCAAA TTTGGGACTG ATAAATGTGA CCAGTTCTGC TT
ACTGTCCA TTGCCTGAAA TGGAGCTTTG AGGTGGACTG TATAATTTCT TCAATCTTAA CTCCAAAT
TC TGATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATTTAT TTACCAATCA AAGTAAAGTA TTG
AAGTTTT CCTGGCAGTT TTCACTTTGT GTTTTAGTCC ATTTAGGCTG CTATAACAAA ATCCCTTAA
A CTGGGTAAGG GATTATAAAT ATTAGAAATT TATCTCTCAC AGTTCTGGAA GCTGGGAAGC CCAA
TATCAA GGCACCAGTA GATTTGGTGT CTAACGAGGG TGTGCCGTCT GCTTCAAAAA TGGCCCCTTG
TTGCTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC CTTCAACCTC TTTTATAAGG GCACT
TATGT CATTCATGAG GGCAGAGCCC TCATGACTTA ATCACTTCCC CAAAGGCCCC ACCTCTTAAT
AGTATCACAT TGGGTGTTAG GTGTCTGGGA GGACACCAAT CTTCAAGCCA TATCATCTCA CTTGGA
AAAA AGTCAAAATA AAACCAGTAG ATTTAATTAA TATTACACTA TTTATAGAAG CATGTGATGT A
TCATTCCTT GTATTAATTT CCTGGGGTTG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACA
ATA GAATTTTATT CTCTCACATT TCTAGAGGCA GAAGTTCACA GTGTGTCAAT AGGGCCATGT TC
TCTGGAAG GCTTTAGGGG AGAATATATT TCATATCTTT CTCTTAGCTT CTCGGTGTCA CTGGCAAT
CC TTAGCTTACT TTGGCTTTCT GTGTCTTCAC ATCATCTTTT TATAAGAACA CCAGTGATAG TGA
TTAAGGG CATACCTTAC TTTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA CCCTATTTC
C AAATAAGGCC ACATTCTGAA GTATTGGGAG TTAGAACTTA AAGCTTTTTG GGAGGGACAC AGTT
CAACCC ATAACAACCC CTAAAATCGA TATTTATTCT CAATTAAGTC TTGAAATTGG TTTCAAAAAG
AGAATATTCT ATTAGAGTTT TTAATGTATA GTTTTAACAT ATAGTTCTTT AGCCCCCAAT TTTTT
TTTTT TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT
GCGGACTGCA GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCTTCCCGGG TTCACGCCAT TCCCCT
GCCT CAGCCTCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTTTTTGT A
TTTTTAGTA GAGACGGGGT TTCACCTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCC
ACC CGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CA
ATTATTTA GTTTTTCTAT AAACAGGGAA ATTTATTTGT GTGGCCCTTA GAACTAATTT AATTTCCA
CT CTAATTCCTA CTTATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC ATA
TACTATT GTATCTGTTG CCTACACTTA GATTTTATTG CCTGCTATAT TTAAATTTTA TTAGTATTT
T AATTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACTTTTGAGA GGCCAAGGCA GAAG
GATTGC TTGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA
AATAAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG TTCTAGTTAC TTGGGAGACT GGGGT
GGGAG GATGCATTGA GCCCAGGAGA TTGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA
GCTTGGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAG
ACAG ATTATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA G
ATAATAGAC AGATTATCTA AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCT
ATC TAAATAGATA ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TA
GATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAA
TG GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTCCTTGC TTATATTACC CACACCTTCT TTG
TTGGCAT TAAGATGCAA ACTTTGTTTT AAACAGTTGA GTAAATCAAA GATGGGACTG TTAAGTTAT
T TGTGTTATTT ACCTGCTTTT TGAAAATGTA AAAATAAAAC TCTAGGTTTA ATTAGTAGTA TGCT
ATTTAG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA ATTTCCTCTT GAATGAGAGA
GAAAATTTAA AGTAAGCAAA CAAATAAGTT GTGTGTCACC ACTCATTCAG TCATTTAACA AGTAT
TTCCA GAGTACTTAT TCTGTGCCAG GAAATGTTGT AGGTGCCCTC AACAACTTAG AGTCTAGCCT
GAGACACAAG TAAGTAGGTA ATTATTATAG AATGGTATGA TCTTTGGAGG ACTGGGTATT GGCTGG
CTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATGA T
GACGTCTAT GCTGATTATA AGGTCAGTGT AGAATAAACT TTGTGCTTTT AAATTTGCAT AGCACTG
TAT TAGAGAGTTC ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CC
AGCACTTT GGGAGGCCGA GGTGGGCAGA TTGCTTGAGC TAGGAGTTCG AGACCAGGCT GGCCAACA
TG GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT AAT
GCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT GAAGTAAGC
C GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAA
ATGATC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG AAAATGGACT ATTTTCAAAT
ATTTTTAATA AGGGTCAAAA TGAGGGATC GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTT
TGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA A
TCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACC
CAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TA
CTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGA
AT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATA
GCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA TTTAAGCTG
C TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC AAGCTGTTCC CCTT
TTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG
AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTTTGGTAA CTGCCATTGA AATTG
CCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC
TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTC
TACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG C
GATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCT
CAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TG
CTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACA
AG AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACC
ATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT TGTTTCCAG
T CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAAC
AAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG
CATGAACTGA CCACCCTTAG AAGCACTCCT-3' (FRAG. NO: 1738) (配列番号3009) 5'-GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATC
AGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGT
G GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGG
CTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACC
AGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC
TATGTGGTCA TTGATCTCCC TATCAATGTA TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCAC
AATG ACTTTGGCGT ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA C
CGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCA
GGG AATTGGGATT CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CC
TGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAA
CC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTC
TTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAG
A TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGA
AGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG
CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCT
TACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT
CTGTATTTTG TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAG
TCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC A
AAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACT
CCT-3'(フラグメント番号 )(配列番号2481) 5'-GATCAAAATT TTTACCTATT ATGCATTTGA TATATAAATA AGTATATAAA TGCACACACA GAC
ACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC TGAGTTAAA
G AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT CAAAAATAGG TGGA
CCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG GGGAGGGGAC AGTTTAATGC
CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTACAG GATGT
GTTGG TTGTAAAAAT GCATTTTTTT ATATCTAGCT TTTTCCATGT GTATATTATA CTTCAAAGAA
GTTCAGTTAA TAATTTCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCTTA
ATCT TGTTTTACCT TAAGCCATCA GTCATTTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT A
TAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTTTCCAA AGCCCGTTTA TTTCTTG
ATT CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TTTTTCATGT ATCTTACAAG AAGACAGCAT GT
GCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA TTTTTCTT
GT AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAA
AGATACA GTAGAAAGTA TTTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATTGGTGCT
A TAGAATGGAA GTTACAGGCT TCTTTCTTTT TTCCCACAAG ATCTGCTCCT TGAGCCCCTA GAGA
CTTTTC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA
AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAAC CTCTGACTGC TGCGC
ATAAT ACATTTCACT CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAGAGGCCA GAAATAATGC
TGAACACTGA CAACCATCTG ATCTTTGACA AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCC
TATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC C
TTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAA
AAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTTCATGA CA
AGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TTAGTTGT
AC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT GGA
AAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA ATTTAAACA
A ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA CAGATGCTTT TCAA
AATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC ATCACTAATC ATTAGAGGAA
TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGACT ACTATTAAAA AGTCA
GACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGTT TATGCACTGC TAGTGGGAAT
GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGATT CCTCAAAGAA TGTAAAACCG AACTGC
CTTT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAAATTGT TTTACCGTAA A
GGCGCATGC ATGCATATGT TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATCG TCTAAAT
GCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TG
CAGCCATA AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA TGTAGTTGGA GGCCATTA
TC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC AGC
TAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG AGAATAGAG
G GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT ACCTGGGTGA TGAA
ATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG AAAACCTGTG CATGTACCCC
TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTTGTGGTA TAAATCTGAG CATTC
ATATT AAAATAAAAT ATTTACCTCA TTAGAGTAAT TAACATTTAT TAAGCAAAGA GCCAAGTACC
TTACACACAT GATGTTTAAT CTCACAATGA TCTTTAATCT CATAACAACC GTCCATTGTA TGTACA
TATG TGGAAATTGA GCCTTGGAGA GATTAAATGC ATGGGGCATG CCATTTGACT AGAAACTGGA A
GCATCAGGA TTTAAACTCA GTTCTGAATG GTTTTGTAGG CTTTGTTTTT TCCACATTAT AGCATGG
CCT GCCATGAAGA ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAAGTGA AGCAAATATT TA
TTTAAATA TTCAAGATAT GCTGTTAAAT TTTTACTCAA AAATTTGAGT ACAGTATGGA TCTTCTGA
AG CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTTTAT GGAGTAGTTC TCAATTTTTA TGT
AGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TTTTCCTCAT TTGGACATC
A GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTTTTA AAATAAAAAC CTTGTTTTTA TATC
AAGTGG GGACATTTTT TCCAAATGAA AACCGTGTAT TCATTTTATA TGATAAAATC AATGTTATTA
TTTTTAAAAT TTTGATTTAA AAATCATTAA AAATAAATTT TCAGATATTA CCTGAAATTC TACCA
TCCAG AGATAATAGT GCTTAAAGAT TTGATATATA GACACACACA CATATATACA TATATATCAT
CCTAAACTTC TTTGTATAAA TGTATATAAA GTTTTTAATA AAAACTAGGA GATTAATGCC CTTTGA
ATGA AAATAAATAC AATGTGTATG CTTTAACATC TTGCCTTTAC TTTATAACAT TTATCACAGC A
GTCATGAGA TAATGATTTA CATGGTCATT GTTAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAG
CTA GCCTCCCTGG ATTTTAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATT GC
TCTTGTTC CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGT
GT GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCTTCA CATACTGAAC ACA
AATATAC GAGCTGTTGT CTTATTGGGC TCATGTTTTT CCTACCACTA AGCCGCATGC ATGCAAGGA
C CATGTTGGTT TTGTTCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA TTCAATAGTT GTTG
ACTATT ATTACTAGTG GCATTTAACA AATATCTGTT AAATGAGTGA AGAAATACCC ATTTACTGCA
AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA CTCTGGAGTC AAACAGGTTT TAAAA
CCTTA TTCCCTCATC CTCAGTTATT GACGTTTTTT TTTTGGCAGG TGTGTGTGTG GGACAACTTA
TTGAACTTTT CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA TTCATTCTTG CAATGT
ATGG ATTTGAGACA ATTGTGTAAG TTTATCAATA AATAGTAGCT ATTTTTGTAT AAGTATTACA T
ATAATATCC AGGCCACTGC TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAA
TGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TTTATAGTTC AT
AGATTACA AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAA
TT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATTTTA AATCCGCGGG AAA
GAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTTAAATGCC AAGTTCACCA TTTTCTAAA
A CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCAAGTT AATG
TCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA TGTCCAATCA GATGAGCAGG
ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATT TTCTTGGCAA GTTCTTTATC AGCAT
TACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTAGCATACC CTGTTGTGCA AATGCTGTCT
GTGTTTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCA
GAAC TTTCTTATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACACAAAAGG G
TCAACCTGG GGGATGGCTA GGGTTTGACT CAGTCGTTAC ATTTCAATAG AGCAGGAAGG GGAAATG
GTG GCCTGTAACC TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GG
AAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACT
CT TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTTTAT TAAAATTTTT AATAACACTC AAG
TATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC TGTGGAAGA
A TCAGCCAATC ACATTTGTTT ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATGTTGC AGCA
AGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG CTAGGCTAAT TACATATTGG
AACTATTTTT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA AGAATTCTGA AGAAAATATA GAGCT
GAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG TTCTATTATC
ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTTTGT ATTAGTATGT TTTTACACTT ATTTGC
AAGG CATAAATAGG TTAGGTTTTG ATCTTAATTT AATTCTAACA TGTATTGTGC ACAAGCTGTG A
GCAGTTTTC AGGAGTTAGG TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTGG TAGAAGG
GTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TG
TAGAATTT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGCAGGC
GG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA AAA
ATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT GGGAGGCTG
A GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA TCGCATCACT GCAA
TCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC ATGTTAGATC
CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCAG TCAACTCTGC TCCCC
CACAG GAGATGCCAG TGATGCATTT TCATGGCCAA CATTGTCAGT CAGCATCATT GAATTACTCC
TGATTATAGA GACACAGCTG CAAACGATTC CCCATTAAAT ATGATGTTTC TTGCAATGTT TGGAAG
GTAC TCCTTTTTAG TAAGGGAAAT CCCCTCTTCT GGCTTGCTGA AAGTTTTTTC TTTCCATTTT A
AAAATCGTG AATTCCTTTT TGCAATATTG AGGTGGTTAT ATGGTTTCTC TTCTCTAATC TGTTAAT
ATG GTGATTTAAT GGTTAGAAAT TTTCTAATGT AAATTCCACT CATATTGCAG AAATAAACCT AA
ACTGAGCA TGAGGCTATA TTTTTTATTT GCTTCTATAT TTGGTTGCTA TACAGTATTA TGTTTAAG
AT TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTATTTTTC CTTCTTGCCG ATTTTTATCT GGT
TTTTAAA TTAAGGATAT TTTAGACTTA TGAAATATTT GGCAAACAAT CCTTGGCAAG TAATTTTTT
G GGGAATTTGT TTTGGCTATT TTGAGTATTA CCCAATATAT TTTAATTAAG TTATTCTTAA TGTT
TTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC TCCAGATTTT GTCTATTTAT
ACCACTTTTC TTTTTTCCTC GATGAGTGTC ATAGATGTTC ATCTATTTTT TTATCTTCTT TGATC
TTCTC TTATTCCTTG TTTCTATTAA CTTCTGAAGT TTATTATTTT CTTTTTTCCA CTTCCTTATG
GTTTATTCTT TCAATTTTTC TCTAACTTCT TAAGTTGGGT GTTTAATTTT TAGCTTGCTT TGCTTT
TTTA GGATAAGCAT TAAAACTACA AATTTTCCTT GTTATTCTTT TGCTGCACCC CAAATTGTTG A
TATTTCTAT TGTCTAATTT CTATTCAATT AGAATACTTT AAAGTTTCTT TTTGGTTTTT AAAAACT
AAC TTTTTAAATT GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGCATAT GGCTTTGAAA TA
TATGTACA TTGTGGAATG GCTAAATTTA GCTTATTAAT GTATGCATTA TCTCACATAC TTATCATT
TT TTGTGGTGAG AGCTATGTGA CTTTTGAACT TATGAGTTAT TTAAATATTT TTAAATTATT AAG
CATATTG GGATTTTAAG TAATTTACCT TTTTATTATT AACTTATAAC AAGTAGAACA GTTAACCTG
T ATGATTCTAC ATCATTGAAA TTTATTGACA TTTGCTTCAT AGTCTATTAT ATGGTCTACT TTTG
TTCATG TTACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA CACATATGTC TATGAAATCA
AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT GTTCTAGGTG CTATTATATG TTGTC
ATGTT TAATCCTCAC CACAATTGTA TGAGGCAGCC ATAATTAATT CCACTTTACA CATGAGGAGC
CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATTTGTAAAG AATGAAGCAA AGATACAAAT GAAGGC
CCAC ATATCCTATA ACTAGATATT TAAGCATTTT AATTCAAGCT TTAAAACTGC TAAATAAAAT G
TGCTCCAAT TTCTATATTG ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAGA AATCTTT
GAT GCTTCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTCCCCA GCCTTCAGTC CA
CCCACCTT CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAA
CC CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC TGG
AAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TGTGGTCTAT AAGGGAGGC
C TCAGAAGACA GGTTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAAGG GTGCTGGAGG AGGG
TCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT CTAAGAAGGG
TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGTCTTCTGA AATTA
ATAAT AATAATAACT ATTACCATTA TTATACCAGT AGCTGTCATT TATTTAGTGC TTATTATTTG
CCAGTCACTG TTCTAAATTC TTTACATGTA TTATACAACT GCCATATAAC TGCCATATGA GGGATG
TACC CTCATTGTCA CCATTTTACC GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA A
GTTACAGAG CTTAGTGAAG CCACAATGTT GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGG
ACA CCTAAGTCAT AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATCTAGTCA GC
CTCCTCCC ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATTTTTGCA TGTGAATT
GC AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCGCTG GATATAGGAA CAG
TGGTTTT AAATCTCTAG GCTTTAACTT TTCTCAGAAC AAGAAATCCT TTTTGGTTTT AATCTATAT
G CACATCTGTA TTTTTCTCAA TTATCGGGTA GTAAAATATA ACTTTTCTTC TGTAATATTT TTTA
ACTTTA ATGAGTGTTC CTCATAATAG AAAAGTTTGG AAACCATTGC TATGGGTATA TACTTTCTAA
AGGGATAGTA ATTTCTCTAG AATATTCATT TAATGCTCCA GAAGTAATTA GCACAATTGT GCAAG
TCTGT GCATCATCAA CTATACATTC TGCCTGTTTA CTCCAAATCC ACATGAAACT GATTATACAG
TCAAAGGCGA GCCCAGTGGA GAGGCATTTT TGGAGACTTC CTGGTACATT GAGACAGGGT CGGCCA
GTCT GCGTTAGGGT CTTGGTCAAA ACTGCATTTC TGAAACTAAA CTCAGATTGC TTTCTTTTAA G
GGGTCAGAA CTGATTCAAA TCTACATTTT TAAAAGCCTT AGATGTGGGG CTTTTCCTAT TCCCAGT
CTC CGCTATTGGT CTTTGTGAAT CCACAGGCAA TTTGGCCACA TCCTTGACTC TCTCTTATAT TA
AGAATTAA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTTTCCTACA AGATCTTT
GA AAAATGGAAC ATTTGCATAA GTCATATTTA GCCAGAACTG TTGTTTTATA TTTTCCTTTC TGA
ATACTTT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA GAGACCAAA
G CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCATCA CGCCTGAATA ATTA
CATTCA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA ACCCTCTGAC ACCTTAATCT
TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA GTTTTCCCAG AAACTAGAGT ACAAA
CTTTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT CTTTTTCATC CCCAGGTCTC TGCCAAGGCA
GTATAACCTG TCCAACATCT CTAACTTCAA TACCTTTGTC TTAGATACTA GACTCTCCTC CTGGTT
TCTA ATTAAACCTG ATCTAGGATC TAATTTTGCC TCTGAATTCT GTTGCCCTTT GCCAAGTGAT C
TCTTCCTCC TCTGAGCCGC AGCATCTCTG AGCTTGCACA CTTAGCATAG CCATAGCACA CACAGCC
TTA GCTTGCAGTT CAGGGTGTTT ACCTTCCCTC CCCTTCCAGA TGCTGGATCC CCAGGGATAG GA
ACTCTGCC CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG TACATTTTCA GCAAATGT
TT AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCTTTTTGC TAAACATGCC TGT
GTCCTTT GTCATTGAAC AACTATTTTG ATCTATTTTC TTCCTGACAT AGGGGTCAGT TCCGAGGAT
G CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGTGA TTTTGTTGTG AATT
GAGAAC TGGCTGCCTA CTTTTGGACT ACCCACTTCA GCAAGAGTGT TTGAAACCAA ATCTATTCTA
AGTAATTTTT TATTCCCTTT TCTCTATGGC ATTAGACACA CAGCTCTTTT AAACTACCTT TCGTT
ATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA CTGTCTAGCT ATATGAACTT AGACAAACTA
ATATCTCTGA GCTTCAGTTT CTTAAAATTT AAAATGAGGA CAATACCATC TATGGCCGGG GATTAA
ATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATT A
AAAATACTG GCCGCAAACC CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA GCTTAATTTT CATGCTC
ACC ATAGCACCGA TTTTCTTCTA AATATTTTGT TTCTACCAAA ATATTTTGTC CCAATTTTGC CT
TTTATGGC TATTTCTTCA TATCCACTTT CCCAAACTAA AGAAGCAGCC CCTTCACCTT AAACTCCT
CC TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT ACAGAGGTTA GTG
TGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AGGCCAGGCT GCTTCTGCC
A CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGTTC TTCTCTCTCT ACTT
TCATTA CCTTCTCTCT TTTTTTTTTT CTTCTCATGT GCTCACGGGA GCAGAGAAAA TTAACTCCTC
TAAGTTTTCT TAACACAGAG TGCCTTAATT ACATATTACT ATTGTTTGAG TTCCTGCCAA CACTA
CGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT ATCAAAAAAA GATAGCTTTC TCCTAAAAAG
GGATTTGGAT GCCTACTAAG ATAACTGGAT GCCAAGATAA GTTTAACCTA ACAAACTTTA TTATTA
TTAT TATTATTATT ATTAGAGATA GGTACTTATT CTGTCACCCA GACTGCAGTG CAGGGATGCA A
TAATAGCTC ACTGCAGCCT CAAAGTCCTG AGTTCATGCA ATCCTTCTGC TTCAGCTCCC TGAGTAG
CTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTTTTAAA AAAATAATTA GGGATGGGGT CT
TGTTGTAT TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT CCTGCCTTTT ACCTCCCT
AA TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAAAAC TTTTAAAAGA AAT
CACATTA CTTACTGTTA TCATCATTAT GGTTACTACC AGTGTTAAAA CAATTGGTAT TGAAAACAC
C ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTCAG ACCTCTGAGC CCAA
GCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAAAGAACTG AAAATGGCCG
GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG TTCCTGCCCC ACCTTGACTG AGGGA
TTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG CTCCCCGACT GAGTACCTTG TGACCCCCAC
CCCTGCCCAC AAGTGAAAAA CCCCCTTTGA CTGTAATTTT CCACTACCCA CCCAAATCCT ATAAAA
CAGC CTCACCCCTA TCTCCCTTCG CTGACTCTCT TTTCAGACTC AACCTGCCTG CACCTAGGTG A
TTCAAAAGC TTTATTGCTC ACACAAAGCC TGTTTGGTGG TCTCTTCACA CAGACCATGT GACATTT
GGT GCCGTAACTC AGATCGGGGA ACCTCCCTTG GGAGATCAGT CCCCTGTCAT CCTGCTCTTT GC
TCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCA
AT TTTAAATTGG GTAAGTGGCC TCTTTTTACT CTCTTCTCCA GCCTCTCTCA CTATCCCTCA ACA
TCTTTCT CCTTTCAATC TTGGCACCAC GCTTCAATCT CTCCCTTCCC TTAATTTCAG TTCCTTTCT
T TTTCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACTCC AGCACTGGTC ATGG
ACTTGG AAAGACAGTC TTCCCTTGAT GTTTAATCAC TGCAGGGATG CCTGCCTGAT TATTCACCCA
CATTTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GATCCTTCAC CTTAGTGGCA AGTAC
CACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCACCTCTCC TGGGGGGCAA
GTACCCCCCA ACCCCTTCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT TGCCTCCTTC ACTATG
GGCC ACCTTCCACC CTCCATTCCT CCCTTTTCTC CCTTAGCCTG TGTTCTCAAG AACTTAAAAC C
TCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC TTTCTTCTGC AATACCGCTT GACCCCA
ATA CAAACTCAAC AATGGTTCCA AATAGCCTGA AAACGGCACT TTCAATTTCT CCATCCCACA AG
ATCTAAAT AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC ATTCTTTT
AC ACGTCGGTCC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAATCC TCCTTCTTTC CCT
CCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTCTTTCC AATCTTCCTT TTCTACTGA
C CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC CCGCCAGGCT GAAT
CAGGCT CCAATTCTTC CTCAGCGTCC GCTCCTCCAC CCTATAATCC TTCTATCACC TCCCCTCCTC
ACACCTGGTC CAGCTTACAG TTTCATTCTG TGACTAGCCC TCCCCCACCT GCCCAACAAT TTCCT
CTTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GGTTAATGCT CCTTTTTCTT TATCCAACCT
CTCCCATCTC AGTTAGTATT TAGGCTTTTT TTCATCAAAT ATGAATACCT AGCCCACTCC ATGGCT
CATT TGGCAGCAAC TCCTAGACAT TTTACAGCCT TGGACCCAGA GGGGCCAGAA GGTCATCTTA T
TCTCAATAT GCATTTTATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAGTT AGACTCC
GGC CCTCAAACCC CACAACAGGA CTTAATTAAC CTTGCCTTCA AAGCGTACAA TAATAGAGTA GA
GGCAGCCA AGTAGCAACA TATTTCTGAG TTGCAATTCC TTGCCTCCAC TGTGAGAGAA ACCCCAGC
CA CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCAAGC ATTCCTACAG GAC
CTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT GCCCTCAGC
C TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT CGGACTGTCC AACT
TGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTCTGACTGA CTCCTTCCCA
GATCTTCTTG GCTTAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCCTGG ACCAT
CACAG ATGCTTTTGG TAACTCTTAC AGTGGAGGGT AAGTCCGTCC CCTTCTTAAT CAATGCAGAG
GCTACCCACT CCACATTACC TTCTCTTCAA GGTCCTGTTT CCCTTGTCTT CATAAATGTT GTGGGT
ATTG ATGGCCAGGC TTCTAAACCC CTTAAAACTC CCCAACTCTG GTGCCGATTT AAACAACATT C
TTTTATACA CTTCTTTTTA GTTATCCCCA CCTGCCCAGT TCCCTTATTA GGCTGAGACA TTTTAAC
CAA ATTATTTGCT TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATTGCTG CCCTTCTTCC CA
ACCCAAAA GTGGCAACTC CTTTGCCACT TCCTCTCATA TCCCCCTACC TTAACCCACA GGTATGGG
AC ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCATTA CTATCCCATT AAAACCTAAT CAC
CCTTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTTTAAA GGGATTAAAG CCTGTTATC
A CTTGCCTGTT ACAACATGTC CTTTTAAAGC CTGTAAACTC TCCTTACAAT TCCCCCATTT TACC
TGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA GGATCTGTGC CTTATCAACC AAATTGTCTT
GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA TCCTCAATAC CTCCCTCCAA AACCC
CTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC ATGCTTTCTT TACTATTCAT TTGCACCCTT
CATCCCAGCC TCTCTTCACT TTCACTTGGA CTGACCCTGA CACCCATCAG CCTCAGCAAC TTACCT
GGGC TGTACTGCCG CAAGGCTTCA TGGACAGCCC CCATTACCTC AGTCAACCCA AATTTCTTCT T
CATCCATTA CCTATCCAGG CATAGTTCTT CATGAAAACA CACGTGCTCT CCCTGCTGAT CATGTCC
AGC TAATCTCCCC AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGCCCCA AATCAGGACA CT
AAAGTACC TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC CTTTCCCACA GGGCCTAA
GA AGGCCACCGT GGTCATTTCT TCCCTTCTGT CAGACATAAT TCCTTGGTTT GGCCTTCCCA CCT
CTATACA GTCTGATAAT GGACAAGCCT TTACTAGTCA AAGCACGCAA GCAGTTTCTC AGGCTCTTG
G TATTCAGTGA AACCTTCATA CCCCTTACCG TCCTCAATCC TTAGGAAAGG TAGAACTGAT TAAT
GGTCTT TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA AGGACTGGAC AGTACTTTTA
CCACTTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGTA CAGCCCATTT AAGAT
TCTGT ATGGACGCTC CTTTTTATTA GGCCCCAGTC TCATTCCAGA CACCAGCCCA ACTTGAACTG
TGCCCCAAAA ACTTGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA TTCACCATTC TCAACT
ACTT GTAAATGCCC TGCCCTTTTT TACAGTGCTG ATTTATACTT TTCCTCCAAA CCATCATAAC T
GATATCTCC TGGTTTTACC TCAAACCGCC ACCCTTAAGT CTCTCTTAAA GTGGATAGAA GATCTTC
AGT GACAAGGTAC ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTTTACT TTTATATTCA CT
CTTATTCT TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAA
TC TCACTCACTC TCTCCTAGCC ATTTCTAATC CTTCTTTAAC AAACAATTGC TGGCTTTACA ATT
TCTCTTT CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AAAGGGGACT CTGCATATT
T TTAAATGAAG AGTGTTGTTT TTACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAA
CTCAAG GATAGAGCCA AAAACCTTGC CAACCAAGCA AGTAATTATG CTGAACCCCC TTGGGCACTC
TAATTAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA ATACCTGTTT TTCTCCTTCT CTTAT
GCAGA CCTTGTGTCT TCCATTTAGT TTCTCAATTC ATACAAAACC GTATCCAGGC CATCACCAAT
CATTCTATAC GACAAATGTT TTAAGGGAGG AGACCACCCC TCATATTGTC TTATGCCCAA TTTCTG
CCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC C
ACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG TTATCTATAG ATTACAG
ACA TTGTATGGAA AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTCTAAT TACCAGTACA CG
CAGCCCCT AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC CTCTCACG
CA GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCACTCG GAGAGCTCGG TTT
TTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTTCC TTCTTTAACT CAGTGTCTG
A GGGGTTTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT AATATCACCC CTTA
CCACAA AATCTTCCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA CGCCACCCCT AATCCTGCTC
GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAAA AATTTTCACT GCCCC
AACAC TTTACCACTA TTTCGTTTTA TTTTTCTTAT TAATATAAGA AGATAGAAAT GTCAGGCCTC
TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGA
AAAT GGCTGGTTCC TGCCTTAACT GATGATATTC CACCATTGTG ATTTGTTCCT GCGCCACCTT G
ACTGAGGGA TTAACCTTGT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTG
ACC CCCACCCCTA CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTTCCACT ACCCACCCAA AT
CCTATAAA ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTTGG ACTCAGCCCA CCTGCACC
CA GGTGATTCAA AAGCTTCATT GCTCACACAA AGCCTGTTTG GTGGTCTCTT CACACCGACA CGC
GTGATAA TTATTATATT ACTTTTAACT AAAACCCTTT CAGAGTCTCG CAGGGAAGGC TGTATATAT
C TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCT
CATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG GTAGGCTGTT ATGGTGATGG
CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG AACAGAAGGG AAAAATCAAA TTGCT
GAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG AAAGAACTGT ACAGAGAAGT CAACTGGCAG
ATGGGAGGAA GTTTAAGGGG AAAAATATAG ATGTCTAAAG AATACATTTA TTCATTTTCC ACAGTG
CAAT TTGGACAAGA AGCCTCTTTC TTGCTTCTTT CTATTCTCAT TAAATCATTA GAGCTCAAGC A
ATCCTTCTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATTT
TTT AAAAATTAGA TTTTAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA TACAGCCCAG GC
ACATTGAT CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGTT CCTGGGACTC TGACAATT
TC ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAGCACAA TCA
TGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT AACAACTGG
C CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC TCCCTGTCCC AGGC
CCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA AATCTGAGGG
CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT TCTAATCTCA GGATAAGGAC TCAGA
GCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GAAAGGTAAG
ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGTTTCAG ATTCAGTTCA CAAAGCAGTT TCATAC
TTAA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT TTCATTCTTG TTTTATGGGC A
TAGGAAGTA AGTCTCAGGG AGGTTAAGAC CAAGGTTTCT GGAGAATTTT ATATTATGAA TCTTGAT
TTA TGGGATTACT ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCTT GAATATAGAA CT
TTATTTTT AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCTT GGCCCTGA
TG TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG TAC
ACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTTGCACATC CAAGATTTAC AGTGTACTA
T AGGGAGAATC TTTTGCAACA GCTTTTGCTA TAATACAGAA TCTGAGATGT CTTTGAGAAA GAAA
AGTGTA ATCATTACCA AAAAATTATT CTCATAATGT GTGCAAATTT GTATGAAATC TATATTGGCC
ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC TCTATTCTCT CATAAGAATT CAGCT
GTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGTT TGCTGAAACT
TATATCAGCA GTGCACTGTA TGCTCTTTCT GATTTATTTG AACATTCATT TATTGAGTGT CAAGTA
ATGC ACTAGATACT CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACTGG G
GAGAAAACA AAACATATGA TAATTTCAAA ATAACAAACT AGGCAAACTA GTTAACACTT AAAAAGC
AGG CTTTATTCAA ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GG
AGCTCATC ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCT
GA GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAA
GGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTTCCATAT GACATCAAA
G AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTTCTTA CTAATAATAT CGTGATAAAA GAAA
CATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC
AGCGCAGGCT ATTTCTCTCT TCTCTCCTTT TGCTTGGCAC TCATGAGATG CTAGGTGTGG AAGTC
AGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTTAA ATAGGATGGT
CCAATTCACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTTCAACTTG AGCAGGACCC CATTAC
TTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC TTTTTGAACT TTCTATAAGA GTGTACCTCC A
CAGTATACA GAAGACGACG TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATC
AAA TTTGCACTTC ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AG
AGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTTTAT GGTCTTAT
TT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTTGA GGG
ATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AAATCTTCCC AGATGCACT
G AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT TTCATGGAAG GATT
TAAAGG ATCTCATGAT TTTTAGTATT CCAAGAATTT TCTTTCACCA AGGGCGATTT AATATGGGTC
ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA AAATTGCAAA ACTTGGAGTG TTAGT
AGTAA AGGTAAATAT TCATTAGAGA TGAGAAGAGG AGCAAGGAAA TGCTTTCAGC TGGAAATCTC
AGACAAGAGG CCAGGCTTTA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCA
CTTC TCAGATTTTC ATGTGCTTAC CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGATTCAGTA G
GTCTGAGTG GAGCCTGAGA TTCTGCACCC CTAACAAGCT CTTTAGTGAT GCTTATGCCA CTGGCGC
ACA GACCCCACTT GGAGAAATTT TTGTGGTGCA TACGGTCTTT GTCTCCAGAT CTAATGAGTC TG
AAGGACAG TGTAGATTGA TTTTTTAAAT TTATGTTTAT TTTAATTTAA TTTAATTTAA TTTATTTA
TT TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCACGGAG GCA
GCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG TAGCTGGGA
A TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA TGGGGTTTCA CCAC
ATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG
GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTTGAGCAGT GGAAAGTCAA GGAAT
TAGAA GGCATGCTTA AATGGAAAGT GAAATTGGAG AAAATTTAAA CTCATGAAAT AGTGGTGGTT
ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAATTTAAT GAGATGGTAA CACATTTAGT TTAAAG
AAAT AAGTGACACT TTTTTTGTGT GACACAACTG TCTTATTCTT GGAAAGGACA AGGAGAGAAT G
AAATATGGT ATGTCTTCAC AGCACCTTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGA
TGA ACTGTCAGGG TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT AGAGACAAAA AA
ATGTTTCT GAAAACAAAA TTTCACATAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC CTGTGTAT
CT TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGATAAACA GAG
TCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG GAGTCATTC
A TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATTC ACCCAAGAAC TTAA
AAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATTT TACCTTTGAC TTGTTCTAAA
AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT TTCAGTGTGA AAAAA
AAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAGCTGGTA GTCAAGGGTC
TTGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCA
TTGC CATTTATTGT GACCTCAGGC TATTTTATTT CTCTGTGCCT GTTTCTTTAT CAGTAATGAA G
ATGTTCATA GACCCTTCTC CCACAGACTT AAAGGCATAT TTCATGATTT AAGACATGTA AACCATT
CAT AACAGTATAC AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTATTGT AACTAACTCT GT
CACTTGCT CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTTTG AATGTGAT
AT CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTT ATGAATTAAT ACAGCCTTGG TCA
ATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG GCCTTTCTAG ACCATCTGGT GAAGCATTC
A AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACAAC TCCTCAATAA GCCA
TGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA TAGTCTCACT ACCATACCAC
TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC TGCTTTTCTC CATATACCTA AATCC
TATCT ATTCTTCATA AGCAACCTTC TTTATAACAT TTTCTATAAC CACCAAGCCA AATGACCTTT
TCCTTCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT TTTTCTGATT TTTTTC
TTTC TATATTCCTG TCTTAACTCC CCAGCTAGGT AATAATTTTC CTGAAATCAG GGACCAGGCT G
ACTCCTCTT GCTGTCTCAA GAAAGCTTAG CAGTTTCCAA CACAAAAATG TTCAATAAAC AACTATT
AAT TGACTGATTA TAAAAAATCA GTGAACCATT AAACTTAATA TAGCAATTTG CTTAGCATGG TA
ATTAGCTT TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TTAAAAAA
AA AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGGTTC CGGTAGCCAG AAA
ACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CGAGTTTGAA AGAAATCTT
C ACATCTGTGG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG AAGCCTTTCC TCAC
TAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG AATAAAAAGA ACCTCCACTG
ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC TTCACAGCCA AACATTTTAA AAGAG
ATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC AGTAATGCTC AATGCTTGGC CGTCTGACCT
CTGTCTTGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACCCTTGTTG CATCCAGGGG ATACTT
ACTG GTTCTCTTGG CAATGTTTGA AACCGTTCCC CTTTCTTTGT TTCCTTGGCA TTCATTACCC C
ACACTCTTT CTCCTCTTCC TTCTCCCTGC CTGGCAACAT CTTTTCATTT CTCTTTCCCT TAGGTGA
CTT ATTAGATAAT GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCTT CCATTCTTAA AG
CACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT ACCTCCTGAA ATGTGAGG
GA CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCCAAT GAGCCACAGT GAA
TGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA AACCTCTCA
T TCTTTTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGTTT CCAGGTGAGA AAGA
TGATAA TTTGATTCTT CTCTCTCACT TTTAGCCAAT TAACAGACAC ATTCAGTTAA TATCACCTCC
TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA CAGGCGCCAT CGGTTTTAAT CTAAT
AACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT CCAGGCTCAC CTGTCTCCCA CACTTGCCAT
ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT GTTTAAACCC CTTTAG
TGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATACATTAG TTTATGATCT G
GCTTCTGGT GCCTCATTTT TCCCCACTTT TTCCTTTGCA TTCTAAGCAA TGGCCCATAC TAAGTTT
GTG ATTGGTAGGA TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAATCATC TCACTTCATT TC
TAGCATTT TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCCTTTCA
TA GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCACTAA ACCCTAGATA CTG
AGAAATA TTTTTCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CACATGTCTG CATCTCCTC
C CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAACTG AAAAATACTT GCCT
CCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC ATTTCTGAAG GACAATGCCT
GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT TTATTCATTT CTCAATAAGT GCTTG
TTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA ACAAGAAGAA CACACCACAA TGTTTTTAAC
CCTCAGAAAA AATTCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT GCCCTTTTCT AATAGG
GATT ACTTGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG A
AGCTAGTAG ATTTATCACC TTATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAACT ACTATGG
GGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GG
AAACTCCT CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT GAAAATAGAA AATAGAGA
AA AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTTCAAGT AAGGGAGAAG GAAGACTCCC ACT
CTCAAAA CTGTCTTTTG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC AAAGGAGAT
T TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTTGATGCAG ATGC
CTCCTG AGGTTCCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 TTGCTAAATT GCCT
GGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA TCTGCCATCT CATCCTACCT
GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAGCTC ACAGC
ATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT TTGGTCTTGT TGGTAGGAAT TGTGCAGCCT
CATCTGAGTA ACTAATGTGT TTTTATCTTA CAAACACAAG GAATATCACA TGGTTCTCCT TTGACT
GGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AACTTTGTGA C
ATACATTTT TGTGCCATAA CTTCAACCTT GGTTCCAAAT GATTTTTGTA CCCTAAGTTT AAATTTG
GCT TTCTTTTTTT TTTTTTTGTA CTCAATAAAA CATCAAGCTC ATTTATTATT GCGAAGAGCG AA
ACAACAAA GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTTGCCCAA ATTGGCTTCT TTTTCTTA
CT TTTTAATTAA TTTTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CATTCTTTTT GAA
AAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGAAT CATTTGGGA
G GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA GGTGAAAGCC CTAT
TTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTCTTTT CTAAACTACA ATTTCTTCAT
CTGTTAAAGA GGCATAATAA TTGTATCATC CTCATTGGGT TGATAAAATA AAATATTTCC AAGTA
TTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA TTACTGTTTT AATCCTTTAA AGTATTAAAG
ACTACTATTT GAAATCTTTT CTTCTAAAAT TCAGCCTGCT GATGACCAAG TGCACTTGAG CAGGGG
GAAT CAAATCTGAA TTAATTTCAG ATTCTGGTTA GCTTCACATA AATATTTTTT TTAGGGATGA T
GAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTTTGAA GAAAAAG
GAA CTAAGGGGGC ATGTGTTCAG TTTCATGCCC TGGTCTAACC CTGTGTGTTG GTTCTGGTGG GA
AATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA GATGTATC
TG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GATTTGGCCT AAA
ACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAATCA GAAAATGAT
A ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT GTTTCTGGAA CTGT
TCCTTA TTCCTTTCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG GCAGGGGACA
AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA CTTCA
TTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT TTTTCTAACT ATTAGAACCC AAAAAGCCTA
TAAATTCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACACAT AGACAC
ACAC ACACACCTAA ACACACACAT AGAGATTTAT GACTTTTTAC TTTTATCCTT GTAAATGCCA T
TAACTATAT TTTGTCTTAG ATTTAGCCTG GGAATGTAGC CATTATTTCT ACCATTGCCT CCATAGG
AAA AATACTCTTC ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA GCAGAATCAT TT
GTAAGTTG GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTTTTT TTTTTTTTTT TTTTGAGA
CA GGGCCTCACT CTGTTGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CCTTGACCTC CTG
GGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC TACCATGCC
T GACTAATTTT TTGTATTTTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG GCTGGTCTTG AACT
CGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGTG ACAGCCAAGG
TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTTATCTTAA AGATACCCTA AGCTTCCTAC CAAGC
CAGTG ATCTTTTGGG GCTTCTGTTT TCTTTGTTGG CATAACTGTA ACTAGCCTAA CTGCCCGTTA
TCTGTTTCCT GTTTGCCCCA CACTGATTCC CACAGCAGTT TTCAAGTTAT CGGTTTGAGA TCTTGT
ACAG AAATGACTCC AAGGTAAAAA ATTTAAAAAC AACCCCTCTA ATTTTTTTAC CCTTGCTTAT A
AAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAGTTTGATT CTATTCTTTT GATTCTA
CAA ACACTTATTA AAAGATTTTA GAATTCGGAA ATAAATAGCT TCCTTATTAA GGTGACTTAC AG
CCCCAAAG TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCC
AC CCTGTTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCG
GGGTCAA GATTTGAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGTCA TTCTTCTTT
T GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTTAGT ACTGTATAAT ACTA
TAAGAT AGTGAGATTC AATCAGCACA GAATTTCTAA TAGCAAGGGC AGAGACATTT TAACTGCTCA
GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA TCAACAATCC CCACCCCCCT CACAC
ACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT AGCGCCCACT ATTCTCAAAT TTAAATGAAA
GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATATTTTTGT AATTGCCAGT GTAAAT
GGAC AGGGGGCAAC CTTTACATAC CATATTCAGT GAACAGAATA CGTACTAACT AATTTGATGG A
AGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGTT AGCAATT
GTT TCGAGATCAT CCCTGAACTT GAAACAGGTA TATCTTTTTT TTTTTTTTTT TTGAGACAGA GT
CTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGG
GT TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCCACCAC GCC
TGGCTAA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT CTTGAACTG
C TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CACA
CCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA TGTTACAGCC TTGAATGGTT
CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTAGTG GGTTG
CTCAC ACTTTAAAGC TGAGACACAC TCATGCCTTA AGGTAAAGGG AGTGATAATC TGGGCAGCAG
ATGTTAACTT CTCAAGGCAG TCCTCCTTCT CTTTTCCTCT CCAGTGACGG ATGGTTGGAA AGCATA
TATG GTGCATTTGG TTAGAGCTGT GGCCTTGGTG AATAGATACT TGGGAGAATA CATGGGAATT T
CTCCCAGGG TTAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTCTTG AAGAGGTCAG GTATTTG
GGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAGCATTGA AA
TCCAAGGC ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATTTTTT CAGAATTAAT TAAGAGCA
GG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGCAGATC ACG
AGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA ATACAAAAA
A TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT GAGGTGGGAG AATA
GCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA CTGCACTCTA GCCTGGTGAC
AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAGAAC CATTA
GAATA TCTCACTTAG TTGTTATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA TTTTTAAAAG
TTTATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTTTTAA TGAAGGTGTG TCCTGGGCTG ATTTAC
ATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTTGGCATC CTGCTTGTGT TGAATCTATC A
CATTTAATT TCCTGTGGGT TTCTTTTTTT TTTCTTTTTC ACTTTAAAGT TGTGTTCTTT TCATGTG
AAG TTAAACTCAC ATACCTTTTT TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GA
ATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTTAAT CATTGAGA
AA CTTTTGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA TTT
CCTTAGT CTATCTCATG ATATTTGACT TTTTTCCTCC TTACATCTCC CAGTAGTAGC CCATTTGAT
G CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGA
CTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GATTTGTGGT TCATAGAGTT
CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC GTTGTATTTA GCTCCATGGA CTTGT
TCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA GGAAAAATAA
AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATTAAT GCTTTTACTT TAAAGC
AGTT GTGCAAAAAT AAGCACTTGA TTTTTACATG CCAAGGACCT GCACTAATTT CTTTCCAATG C
AGTAGTTAC CACTTCCCTC TACTTCCTTC ACGAATAAGT AAAAGGGCAT GTTTAGAGAT ACTCTTG
TAA GTGTAAACTA AGTTCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA AAAAAATCTG TC
TCCTGATA CTAACATTTG AAGGAATCTA CTTTTTTACA TATTGGCAGA GGGTCTGATT CTATCCTT
AG TTCTTCCCAT TACTTTGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAATATAT GAT
TGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG AAGATGAGG
A GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCT
GCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC
AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT TTAAAGACTT TTGTCATCCA TGCAG
ATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT CACATGCTAG CTTAACATGC ATTTGCTTTA
GCACCTATTG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACATGATT CTTCTC
ATAT ACAGATAGAT TTTGGAGGCA TTAGCTTAGT GATGATTCAG GAGTATCCAT TATTTGGGGA A
GTAGGTGGT CATTAGTGAC CTTTTACAGG CATTTCAATG GGCTAACAGA GATGTTAGAT TGTAGTG
GAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GG
TGAGAACA AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT TTTACAGT
GA GTTAAGCATA CAAATTTATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TGTAAATGTT TAT
GTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TTTCAGTTTT CCAGGACAA
A CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT TCACAAATGG TTTT
CTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT
GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACTG AATCA
CTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATTTCT GAGTAGAGAC CCTCCCTTGA
GCAAAGGATT TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATTGC TTCCAGGCTT TATTTT
CTTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA G
AGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATG
CCA TATGGCCTCT GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGTTTCATC TG
TTCTGATA TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAA
AT TCCAGTAGGT GGGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CACTTCTAAG AAT
TAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT CGTAAGTTC
A GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAAAAAAAAA AAAA
ACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTTTG TTTTTCAGTT GTTATTCTCC
TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG AATAAGCCAA ATAAAACAAC CAAGA
AAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TATTAAGTAG GACACCACAT AAAACAGGTG
TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATTA TTTATGCAAT GGCAAT
GAGA AAAATAAAAA ACACAGTATA ACCATGCTGT ATTGCTATAA GTCATGTTAC ACACTGGGAG A
TGGCTTCAG GGGTATTTGG TTTTTACTTT TTGTTTGGGA GGTTTTTCAA AAAAATTTAG TTAGAAT
AAG TCCTTTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCTAAGTTT GA
CTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGT
CT GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GGTCCACAGG TGG
TTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC TGAAGCTGA
A GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCTCACA CTGA
ATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT GGATTTGAAT
CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG GTTACTTGAA CCCTCCAACT TCAGT
TTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTTTAT CAAATTGATA TGGAAACTAA
ATGTAATTCA ATTAGCATAA GTCAAGGACC TTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTA
AACA TTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA A
TAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTAC
TAG AGTATTGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCTTTGCAA GG
AGAGAATA TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAG
AA TTTTAACTCT TTTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA TTG
GTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GTTTTCACAT TTTAGACCCT GCCATGCCA
T TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA GCCATTATTG CTAC
CTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATTTTTGTA TTTGGAAACT
ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TTTTTTCATT GATTT
AAAGA GTATCTATTA TATATCAAGC ATTACTCTGG GGCTTGAAGA GCTTAGATTT CACCCTGTAG
GACAAAATGG TAGGTAGAAA TTAATGGGTG GATTGTCATG TATGTGTGAT GTGTTTTAAT TGCTTT
TAAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATTTGAGGGG AGCTAATTTA AAATTGTGGA A
CTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGAC
AAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA CCCTGCATAA AT
GTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGAT
AA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AAACATCCCA AAG
GACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC ACATAGATT
T GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG AGTCAGAAGA GCAA
TATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT
CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAA
GAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC
ATACCAATAA CATAAGGGTT AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGG
AGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTATTTCAGT TGGTTGACAT T
TAAATGTAT TTTGGTTTTA ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAAATTA AATTGTC
CAA TTCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CATTTTGTGG ATCCCAAAGA TG
CAATGATA AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA CAAGTGAA
CA GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAA
GCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCTTAA AGATGACATG TTTTTTGGCC ATGTGCAAA
A TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT AAGTGTGGAG AACT
GCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT GGGTAACTCA GCCTCCTAAT
GATAAATGGC ATAGTTTCTT CCAGACCTTA GAGTTCTAAT TAATCTAACA AGCTCATTAG ATCGT
GAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT CCTTATGGTA ACCCTGACAG CTTTTATCCC
AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG AAGTGAGTCG AAACTTCATG CTGACT
TATG AAATCTTTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC TTTCTGATCA AAACTTCCCA T
TTCTCAGAG TGGCTAGTAT CATTTTGTTC CAACCAGCTT CATGATAAGC TATAATGATT CCTGTGA
CTT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT AC
CCCACATC ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGCCAC TGCATGAC
CA GGGCTGGCAA GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACATTTTA GTA
CTCAAAG TCATTTCTTT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAATC AGGAAAGGT
T TATTTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT TTTACGTATA AAATACACTA AGCA
TATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC TAATATTCTG TAACACTTAT
AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT TGTTTTTAAT GAGTGAGAAG GTTAA
ATGAT GACCTGACCT CAATCATTTC TGCATGCAAT TATTTCTTGG CAATCCCTTT CTTTATAGAA
ATCAAAGATT AAAAAGTCCA AATTTGCTAA AACGGTAGAG TCCAATTTAT AAGAGACCAA ATTAAC
TATG GTTCATTATT AAAACATCAC TTGGAAAATG CTGGCTGTTT TGGAATTGTA GAAGATTTTA C
AGAAATATT CATACACCAA AGATAGTGCA ATTTTTATAT AAAATTATAT AAGGTTAGAC CAAGAAG
GAA GCACGCAGCA CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT TT
CCAACTGG CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTGATT GTCTAGCT
CT TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GGGTATAGCT TTT
GTGCACA GGGACAAATC TTACACACCA AAAATTCTTA GGAGTGACAC GATGCAAGAT TATATAGAG
G GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT TCCATGGGGT AAAT
CTGAGT ATTCTCTTAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGTCTTG TCACTCCCTA
CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TGGCAGGCGT CATCGTTCCA TTTGCCTGCA TCTTT
GTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT TGTTCTTCTT GTTGTTGGGC TCACCATCTC
CCCAGTTCTC TGCTTCTTCA GTAAGAGATT TGTTGGTTCC CACCCACGTC CATATTCCTC CTATCT
TCCG GATTCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACTCAATTTC C
GCCTTGTTT TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAGCCCT TTGCCAG
TTC ATGGGTTTTT CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGGAAATCT GC
AAGACATC AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC ACTACTCC
AG GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GAT
CACAGAA TAGTTGTTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CTTGAATATA AGATGCTTT
T ATCTAAGGTT CTATTTGAAA CAAATTTAGT GGTTTTCTAG GTTTATTTTC TTATTAATTT TTTT
CTCAAA ATTATTTCAG GTGAAATTTA ACCAACATAT TTTAGACATT CATATTTCTT TTTCTTTGTA
GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA TAACTATACA ATTTACGTAT ACTTT
TTAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA TAATAAGGAC
AGGAAGAACA GTGACATACT TTTAAGTAAC CTCTTTTACA TAAAAAACAT TTTATTTTAC CATAGG
AAGA ACTGCTTCTG GAAAAGCCCA ATATACCACT CAACTCTTAT ATATCTAACT GTATAATTTT T
AAAAAGAAC AATTTACAAA GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCATGTT CTATACA
CAA AGAGACTCAA CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA GGGCTTTGAA GA
TATCTAAT TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTAAGC ATGGTATG
AT CTACATGAAT CACTATTTAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC ATA
AAATAAA CATTTTGAAC AGAGTTTTGA ATGAGCATTC CACTAGAATG CAAGTTCTAA GAGGGAAAA
A ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA TTGTAGGGAC TCAG
AAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA GTGCAGACAT GGCATAAGGA
ATGTGTGAAC GGGAGAGTTA GCATGTTTGC TTGGCTAGAG CTGAAAATCC AGGCTAGGGA GAAAG
AAGAC ATTAGTTTAC TTAGGAAATG AAAAACCAAG TTCAAAGCTA TTGCTGGAGA GTCTTCAAGA
ATCAGATATA AAATTTGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCCCCGTC CCTTAA
TAAG CTCGTATTGT AATTGTAGAA ATGACATTAA TGTACACTGA ACTATGAATA AAAAATAGAA A
ATGAGGTGC TAAATATTTG GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAATTAA CATTATT
CCT TTATAATTGA GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT GGGCTATTAT AG
GTTAAAAA TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT GTTTACAG
AA GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA ACTAGTGGAT ATT
TAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC CACAACAGA
G CATTGTCCAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC TCTGACATTT CCAT
GGAAAT ATCTGCAAAT GAAATACAAA ATTATATTTA GATGTATACT CTTAAACCAC ACATTTATAG
CCTTTGAGGT GGTGCTTACA ACTTTCTTAA TAATCAGAAT AAAACACATA TGTCTACTAA CCCTG
TCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA ATTACTTCAA ATTTACATCA GAACTGATGC
ACAGTTTTGT TTTGTTCTAT TTTATTTTTA CGCTTTAGTC TCAAGTTGCT AATCGGTACT GCCCTG
AATT TTTTCTATGG TTTGGTAATT TTTATACCTG CTTTTCTGCT GAGCTATTAG ATAAAACTAT T
TAATATTTA CTATGTATAT TTTTTAAAGT ATTGTTGCTG CTTAATTAAC TATTGATGCT TATATTT
AAT GTTATAGCCT CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA AT
TAGATAGC CAGACACCAG GAAAGAAAAG TATTTCTTTT TTTAATAAAA AGAAATACCT TTTTGAGC
AA CTGAAATGAC AAAGTCACAA ATTTCCTGCA CACCTTAAAA TATACTTAAT GTAAATGACG AGT
TAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT TGTGCACAT
G TACCCTAGAA CTTAAAGTAT AATTTTAAAA AAATTCTATC TTCCAAAGCA TATCACTTCT CAGG
TAGACA CAGTGTTTAT TGCAAAAGAT CTGATTTCAA TAGTATTTCT TCAAGAGTCT CCCCAGAGAC
AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA TTTCAGGATC ACTTTTTTTG AGGGT
CTGAG AAAATGTTTA GTTTCTATAT TATTTAAAAC CAGAATTGAA ATGGGGTGAT TCCTATCCTT
GCCACCTGCC TCTACAACCC CAAGAGTTTC TATCTGAGCA TCTAAACGTC TTTTAGGCTG AAAGGC
TCAC CATGGCTTTG CTTGGTCCTT CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC TTGACTTAGC A
CAAGGGTCT CAGGTCCTTG CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTGA ATGTCAA
CAG AAAGCCTTGC TTTCTTTCAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT CCTCCCCTTT TC
CCTCCCCT TCCTCCTGCA CTTCTCTTTC CTCTTTCCCC ACCCCTTTCC TAGACTGGCC TCTATTGC
CT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CTCTCTTCCT TCC
CTCCTTT CTATCCTTCC TTCCATTCTC CTATGCATCT TTCCTTACCC TCCTCCTCCT TCACTCATT
G TTGTTGCTGT TCTTCTTCCT CTTCTTTTTC CTCCTGCTCC TCTTCTTCTA CTTGTTCTTG TTCT
TGTTTT TGTTTGGTTC TTGTTCTCCT CTTCCTCCTT CTCTCTCTCC TCCTCCTCCT TCTTTTCCAC
CACCCTCCCC TATCTTTTTC ATAAATGCTA AACTAACTCT TGGCTACCTG TGGTAAATGG CCCTT
GGAAA TTGCAAATAC TACAAATCAA AACTGCATTT CAGACATATT TATGATGTTT GCAAAACTTC
AGTAGAGCTA AGCAGTGGAC TTGACTCGTT TCGGTTCCTT CACCTCCGTC TTTCCTTGCT CACCAC
CTAG TGGACGTCCT TGTTAGTGGC ACTTCCTGAA GTTAACCCCT GAAGAGAGCC CATGCTCTCT A
GCTTTTCAC CGTGTAGGTT TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTATAAA ATGAGAT
GGT TTTATAAGAC TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CA
CTGATGTG AGTCAATGAG TCAAATGCAA ATCAGATTTG CATTTTTAGG AAAATAATAA TAACAACA
AC AAAAACTCTG AAGCTCAGCG CCCCATATTT ATTATATTGT TTAATCTTTA TAACAGCTCT CTG
CTATAGA TATGATTATT ATCCCCATTC TAAAGAGTCT CAAAGAGGTT AAGAAACAAA TTCAAAAAC
T AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGCC
TTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGATTAAC AAAATAGATG GACCACTAGC
TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATTACC ACTGA
TCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT TTACACAAAT AAACTAGAAA
ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCA
AATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA A
AAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGCT GGTACCA
TTC CTTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATTTTATGAG GC
CAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG CCAATATC
CC TGATGAACAT CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAA
AAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA CATACACAA
A TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT GATTATCTCA ATAG
ATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAAT AAACTAGGTA
TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA CAAACCCACA GCCAATAGCA TACTG
AATGG GCAAAAACTG AAAGCGTTCC CTTTAAAAAC TGGCACAAGA CAAGTATGCC TCTCTCACCA
CTCCTGTTCA ACATAGTATT GGAAGTTCTG GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGT
ATTC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTTTGCAGAT GACATGATTG TATATTTAGA A
AATCCCATT GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTAC
AAA ATCAATGTGA AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA AT
CATGAGTG AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAG
GA ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA CAA
ATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGC
C CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT TTTTCACAGA ATTA
GAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT ATAGCCAAGA CAATCCTAAG
CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC AAACTATACT ACAAGGCTAT AGTAA
CCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA
GAAATAACAC CACACATCTA CAACCATCTG ATCTTTGACA AAGCTGACAA AAAGAAGCAA TTGGGA
AAGG ATTCCCCATT TAATAAATGA TGTTGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC T
GGATCCCTT CCTTACACCT TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTAAATG GAAGACC
TAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AG
ACTTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTA
AA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAG
AATGGGA GAAAATTTTT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAAC
T TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGAT
GCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA TCACTGGTCA
TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAATGGCGA TTATT
AAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTTT TTACAGTGTT
GGTGGAAGTG TAAATTAGTT CAATCATTGT GGAAGACAAT GTGGCGATTT CTCAAGGATC TATAAC
TAGA AAAACCATTT GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATT ATAAATCATT C
TACGATAAA GACACATGCA CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGAG TTGGAAC
CAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TA
CTATACAG CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG GAAACCGT
CA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCATAAGTG GGA
GTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATG
T GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG GTTGATGAAT GCAG
CAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT CTGCTCATGT ATCCCAGAAA
TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG CCTTAGTCAC ATAACTAGTA AGAGA
CATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC CAAATCCATG CTCTTGATCA TTAAGCTGAA
CTTATGGCAG GAACTTGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAA
AGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTT ACTTTTTTCT AAGTCCTCTC C
TCTAATTCT CTCAATCTCT CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTGTCAC TCAGGCT
AGA GTGCAGTGGT GCGATCATAG CTCATTGCAC TCAAGGAATC CTAGGGTCTA GTGCCCCTTC TC
CCTCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAATTTT TTTATTTT
TT ATTTTTGTAG AGACAGGATC TCACTATGTT GCTCAGGCTG TAATTCTGTC TTGAAGCTTG TCC
AATCAGG CTTTCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT TCACTAACA
C AAACAGCCTA TTCTCCATCC TCATCTTACT TCACCAGGGA GCTCCTGGTT TTCCTCCTAC TTCA
CTGGCT ATTTCTTCTG TATCATGTGT TGATTCTCCC TCATCTCCCC AACCTCCAAA CCCTTGGAGT
ACTCCAGAGA TCACCGCTTT GCTCTTCTGT GTCTAACCTC ACTAACTTGG TGGTCCAATT CACAC
TCTTG ACTTTGAATA CCATTTAAAT GCGAACGAAT TCTAAATTCT GTACAACCAG AACCATTCTC
CTGTAGCCAA ATGCCTACTC AACATCTCCA TCCCCAAACA AATTTAGTTG TTCAATAAGC CTCTCA
TATT TTACATATCC CAAACTGAAC TTCTGAATTT CTCCTCCAAT CTGTAGGGCT CTTCCCACAG C
CTTTCCATC TCAGTGGATT ATAACTCCAT CCTTCCAGTT ACTCAGACCA AAACTTTTGG AGTTAAC
TGA GACACCTCTC TTTTTTTTCA CAAGTCATAT CCAATGTGTC AACAAATTTT GGTAGTGGAA AT
ATTGCGGG ATTTTTTAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATATTTATTA TTTAGGTG
CA CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGTT AAGTTACCTT TTA
AGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA GTGAGAAAT
A AAGACAGTTA TTCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTTT TCAAGAAGAA ACAT
GTTTTG CGACTTGAGT TTATCTGTCT AGTGACCTTG CAGCTGCACA GCTAGAGAAA CAGGGTCTTC
ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGTTAA TTTTT
AAAGG GCTCCAGCTC TTTCTCTTTC TCAGGGGGAG TTGGGTTTTG TTACATACAA CTGAGTTTCC
GCTTACACAT TATTTAATTT CTTTTAATTC CTGTTCCAAA AGAAGCCAGA TACAAAAGGT TACATG
TTGT CTGATTCCAT TTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGATT A
GAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAGTTTT CTTCTGA
TAA AAATATTTTG GAACTAGATA GACATTTTGT TAGGCCATTC TTGCATTGTT ATAAAGAATT AC
CTGAGACT TGGTAATTTA TAAAGAAAAG ATGTTTAATT GGCTTACACT TCTGCAAGCT TTACAGGA
AG CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTACA ATCATGGCAG AAG
GTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACA
G TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA CAGTACCAAG AGGA
TGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA GGCCCCACCT
CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA GAACACGGAT CCAAACCATA TCAGA
GATGG TGGTTATACA ATGCGATAAA CGTCACTGGA TTGTACACTT TAAGATGGTT GTTTTATGTT
GTGTGAACTT CACCTCAATA AAAAAAAATA TTTAATGTAC ATTCAGCCAA AAGAAGATTT GGAATA
GGAA AGGTCATGGA GATATATTAA CAGCCATTTG ATGGGTGGTA AGGAAAAGAG TGGTTATTAG A
CTGTTTTGT GGCCCTCAAA AGGTAGAACT AGATCGAGTT GGTGAGCATT ATAAAACCAT CACAAAA
CCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TGAGACATGA GGGAAGTACC AG
TGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCCTTC
CC TAGCCTACGC CTCCATTACA GATGACCGCA AGATTTATTT GCTCATTGCT GCCAACCAAG GCT
GCACTCA CTGCAGTTGC TATCAGTTTA TCATGGGTAA AAGGAATGTG CAGTAGAGAA CTAACTAAC
T GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT TCCTTACATT TGGC
ATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA CCTAAACTGT TCTCTCCTGA
CCCAACCTTG ATTTTCATCC CAAATGCTTC CTTGCCATCT CTGGGATTCC TGTCTTCACC ATCAC
CAAAC TCCCCTCAAT CTTCCAGTTT CCTGTTCAAA CTTTTCTCCT ACCTCCTTGC TTTGTCATTA
GCCCGACTGC CTCCCTAGGA CATCACTTCC CCTGCAGATC TCTCAAGATG ACAATATTTA TTCTCC
ACAC AGCACATACT TCAGGGTTGG AAGGCAGGGG CAATCTTCTC CTTTATAATG AGTGCCTCTT A
TATATGTTT ATTCATCTGC CCTCTTGTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAAT
AAC TCTGCTTCTT TGAAGCTTGT GACACTGAGA TAAACCATCT CACTGTCCTC ATTGTAGTGA CC
TCTCAACT CCTCATGCAA GATTGGCTTT GGCACCTAGT TCCTGATCTT CCTTTCCCTG TAAGCACT
TC TCATAGTCTT ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA GCT
CTCCAAT GACATTTTCC TCCACTAGAC TTGAGCTACC TCCTTCCCTA GGCACAGCCT CAACCTCGA
C AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTTCAA ACACTTCACT CTTTAACCAC TGTC
TCCTAT TCTTGCAAGT GTATTGCTCA AGTATCTCAT TGCAATGCTT TTTACTTCTA CCTCATTGAA
CCTCCAGGCC ATTAAACATT TCCTTATTTC TAACCATCAG GTTTCTCCTT ACTTGTTTGT TTGTT
TATTT GTTTCTTTTT TTTTTTTTTT TTTGAGACAG GGTCTCACTC TGTTGCCCAG GCTGGAGTGC
AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTTCAAGTGA TTCTCATGTC TCAGCC
TCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGATTTTGT ATTTTTATTA G
AGAAGGGGT TTTGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCT
CAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT TTCTCCTTAT TT
ATTTCAAG TCTATGCTGC ACTATTAAAA CTGCCTTGAC AAAAATTATA ATAGTGAGAA AATTATGA
CA GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCTTT ACCTTCCAGA CTGCCCTTAA TAA
TTCCTGA GCTTGGGCCA AGCTATCTTT GGCAGAAATT TAGTTTATAG TTTAAATGAT AATAGCCCT
T CTCCAAAACT AAACTGCCTT TGTAAAACTA ATAAAAGACC ACCAATGAAA GGTTAGGAGG ATGA
GAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC TGTTATTCCG GAGGTCACAA
GATTTGCAAC ATCGCCAATT ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTGATTGGC CTTTT
GAGAT GTCTTTTCAG ATTCTTACAT TTCAACTGGT GGCTCTACCT GGACCCATCA ACAAGTCCTG
TGGCTCCACC CAGAAGCAGA CTTAACATGC ACAAGGACCA TTTTCCACAC CGCTATGATT GCATCC
CAAC CAATCAGCAG CAACCATTCC TCTGCCTGCC AAATTATCCT TGAAAAATCT TAGCCTTAGA A
TTTTGGGGG AGGCTGATTT CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGGCTCT GCATGAA
TTA AATTCTTTCT CTATTGCAGT TCCCATCTTG ATAAATCACC TTTATCTGGG CAGCAAACAA AA
GGAACCCA TTGGACAGTT ACACTGTTGG CAGATATATC TTGCTTCCAA AATTGGATTT TTGTTTAA
TG AATTTATTCT GTTTTCTTGA TATTTACAAC TGTGAATGTT GTGTCTGAAT TCTCTTTATT TCT
TGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG CTAATTACTC AACACGGGG
G GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA TTGTCCACTT TTCCCAAACT ACAT
AGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA AATACCACAT AGACATCAGG
GACACTTTAA ACTAATCAGC CTATAGTCCT TTTTCAGTAA TTTCCAAACC TGGTTGTGCA TCCAA
ATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA TCCTACTGAA
TCAGAATATT TTGGGTTGGT TCAGGAACAT TCAGGAGTTT TTCAGGGTCC AAGGTTTATA TAATTT
GAGG TCTCTCTTTG AGAAAAGGAA CGTAAAAGCG TCTTGCTTTT ATAGATCTTA CAAAGATGTA T
TACCATGTA AACACATTCC TAGGACCCAG GCCCTTGTAA TTTAAAGGTT TATCTAAGTA ATGGGCC
CTG AAGCTTAATT TTCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTTT AGGAATATAT CT
CTCTGTGT ATGTGTGTGC ACATTAGCAT GTACGCTTGT GTGGATTTTT TTTTTTTTTT TTTTTTTT
TC TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG CAA
ACTCCGC CTCCCAGGCT CAAGCGATTC TTCTGCCTCA GCCTCTTGAG TAGCTGGGAC TATAGGCAC
G CACCACTATG CCCAGCTAAT TTTTGTATTT TTAGTAGAGT TGGGGTTTCG CCATGTTGGC CAGG
ATGGTC TTGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTGG GATTACAGGC
GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGTTTTAAGC TCCCAGGTGA GTGAATACAA AACTA
GATCT TTCCCTTCTG TAGCATCTGT ACTGTTTACT CTATGCATCT CAATATTTTT TCTTTTAGTA
TCTTTCCTTT TTCTCTCTTA TTACTTCCTC TTGTGCTATT TTTACACCTC CTTTTTTAAA AAATTT
TTTC CCTTTTATTT CTATTGACCT TTAGCCCTCA CAATGATTCC TACAAGCCCC ATTTCTGTAA A
TGGGGATTG AAATAATTGC TGGACTTTTG AGAGATAGAT ATATTAAATT GCAAACTGGC AGTAGTG
GGG GCAGTTGATA CATAACTAGG TTTTAAAGTC TAGCCTTCTG AGACCACTCA TTCCATTTGT GA
AAAGTGAT TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC CATGCATTGA TTTATTCA
TT CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGAATACA GCA
ATGAACA AGGTAATTTT TCCCTACCCC TAAGGAACTT AGAGTTTAGT GGGGAAGACA GACATTAAA
C AAACAATTGT GCAAGTAATA ATCTATAATT ATTTATTACA ATTAAAGGAA GGAAGAGACA TATG
GATTAT GAGGGCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC TCGTGAAGGG ACATGTATTA
GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG TGTGT
GTGTT GGGGTGTGGG GGTGTGGTAT TTTTTATAGA AATTGTCTCA CACAATTATG GAAGCTGAGA
AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAA
GGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCTTAAAAAG A
CAGTGAATT CACTCTTTTT GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACCC ACATTGG
TGA AGGCAATCCT CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CA
CTGAGAAA TAATGTTTTA TCAGGGTGAT AGAAATCTTC TGGAGTTAAA CAATGGTGAT AGCTGTAC
AA TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG TTTTATCTAA ATAAAATTTC TAA
GAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATTGTCAAC CTTTATAGTG TTATGTCAA
A TAGGTCTGAC ATAAGCTTAA ATAAATATAT ACTTTAAAAA TTATAAAATA TTTTAAGTTA TAAT
TTAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTATTTCA CACAGCTAAT TTCTAATGCA
GTTTACATAA ATATTTACAA CACTTAAACA ATTTCAAAGA AAATAACACT GTATTCCATA CATAG
CCTGA TCACAGTAGT TGTTCTCTCT TATTTCCCAG AGTTTTTCTG CCCCTTTAAA AGAACCTCTG
CTGTTCTGAT CCTTATCACA TCTCTGTTTT GACTGTTGGC TTTGTTGTTG CCAGTGTTCA GCCAGA
ACTT CTCTGAAACT TTTTTTTCAA CACATGCTAA GTTAATGGAA GTGTAGGAGA GTTTTGATTC T
CACACTCCT CAAGGCTAGA GCAGCTTTGG CAATTACTGA CTGAGAATTT TTCATTGCCA GTGATCA
ACT GAAAACTGGA GATTCCTTTG GAATTGTTAA ATCTGCTTAT AAATAAACAT AAATGCTTGC TC
ACACAGGC ATTCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTATT
AG ACATCTTCAT TCGTTAAAAA TCTACCAGAT GACTCTTTTA CATGGTGAGT TTCTATTGTG AAT
TTAAAAT CTTCCATAAT ATACAAGAAT TATGTTTACA TATCATATCT GACAAACATC TTTGTAGGA
A TGCAAAGCAC ATCCATCTTT CTGTATTCTT TTCCAACAAA GACATTCATA AAATTATACC TTTG
TGTGTT TGCATTTATG CTTTTATTAG TTCAAAACGT TTGGCCTCAT GGAAGTTTTT CATCGTGGAA
ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC TTCCATTCAG TTTTTACTCT CCAAT
TCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA CACTCAGAAC TTTATTCTGG TTAACATCAT
GCCTTGCTAG GGGACAATAG TTTCCCTTTT TGAAATAAAT TTAAAACAGA TGTAACATAA TTTGTT
AATA AACAATGAGG GGGTAATCTA GAATAAGTAA CTTTTACCAT ATCATAGTTG ACAGCATTTA C
AAGTTTTTT AAGTCCCTAC CACACTTGTA TTGAATGAAG AAGTATGGAA GATTATAATA TATTCAA
TGC AAGTAAAAAT ATCACAATCC TTAAGAACTC TTTAAGAAGC ACTGAATCCC ATAGGGATGA AA
GTGATTAA ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TTGCACCATT AACAACCC
TC CATGCATTTG CCTGTGGGCA TTCAACATCT GTCATTTTTT TAAGTTATAA TATTTTTAGT CAT
TTTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA TCAGCTGTC
G AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG TGCCAAGATT TTAC
AGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC TTGGTCTCTT CACCTTTGCT
TGGAAGAAAA TATCCTTTCC CTTCATTAGC CAACACTTTC TTGATCCTGA GAGTAGGAAA GGGAA
CACTG AGTCTTTTCA GTTGAAGGCC GTCCTTGCCT GCTGGACTTT GATCTATTGA AGTGGTGATG
GGTGTTGCGG TTTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAG
AGTT ATCTGTCTCT GTTAACTTCA GTGTATCCCT CTAGTTCCCC AGATGCACCT GTTTCTGTAA A
TATAAACAT GCATGTCATC AGAACACTTA ATATTCTGCA TACTGATCAT GACAACAAAA TGTACCT
TCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT TCAGTTAGGA CA
GTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAA
TT CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAGTTGTA ACA
CTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG AACTCTTTG
T GCTTTCTGCT CAATTTTTCT GTAAACTTAA AACCGCACAC ACAAAAAAAG TTATTTTAAT TTTT
TAAAAA GTATTCAGAG GGACTTGACC TTTCCAAATT CTCTCAAAGC AGGTCGGAGT AGTTAAGAAC
ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC TACACCACTT ACTAGCTTTG AGATT
TCAGA CAATTTACTT AACTTCTCTG TCTCATTTTC TTCATCTGTG TGATAAGAAA TAAAGTAACA
GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTTT GAGAGGCCAA GGCGGGTGGA TCAGGA
GTTC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT A
GCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TTGCTTG
AAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GA
ATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAG
CC CCTATCTCAG AGTTCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCA
GCTATCT TCATTATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG TTTCTTTCC
T CTCCTTCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG ATTTCTCCCC TGCT
CCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG AGCATGTAGA GAAGATACCT
CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC TTTTGAACTT AAAGGATGTA AGAAG
GCTTT TGGTAGCTTC CATCTGATTC AAGGCTTTGG CAGCTGCTGT GGAATACATG AGAACACTAG
GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGCATGCT TTGTAT
AAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TTGCTGCAAA AGAAAAGACA AACAACCATT A
ATTCAGACT AAATGACTTT TAAGGATATA TTAAATCCAG ATACAATATG ACTTAATTCA TCAAGTG
TTG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TA
GGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTA
CG GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CTTAATTTAA ATG
TGAGATT TCCTATTTTG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACTCT TAAACATGT
A AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA GAGACTCTCA AATT
TAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT TTTCCTTAGA GTGCTCATCA
TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAG
TTGTA CAATATTAGG CACGACTAAC ATTTTTATTT CCTGAAACAC TTCCCACACT GAGTTGTACT
ACTAACTCTT TTCTTAATAC TTCTGCTTAA TTATACTGCA TTTTATCCAG ATTCTAATTA TTGTTT
AAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATTTTCAAAA ACATTTTTGA A
GTACATTCA TAAACTTCCT CACCTTTCCG TAAGCATTTC CGAAGCCAGA GGAGAAATGG TGCTAAT
GTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCAGTGGGA GC
TAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA AGTCTCTCCG TCCTGTCC
CT TTGGCCTTTT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG AAG
CAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT TCCACCATT
G GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC TTGGTTAATA AACA
CTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT TCCCCTTTCT CCTCTCCTCT
CTCTGTCTCC TTTTTCCAGT TGTCAGAATT CTACCCTTTC CATCAACATG CAACTTCTGT TTTTT
CTCTA TCCCCATACA ACTTAATATT CACAACTTGT CAACCTGGGC GAACTTTCTG GTTTGGATAT
AATGAATAGT TGATTACTGT AACAAGATAG CTCCCCCTTT TTCTTTTTAA TCACCAGACA ACCACC
ATCA ATCAATGCAT CACCTTCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT G
TCCGAGCTG CAGAGCCATT GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACA
CGG GCTCCCCACT GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA CATTTTACCA CT
GCAAATGT TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAAAAC TTGCTTAA
AA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTTTTC AGCATGTAGG AAATTAGGAC CAA
ACCCCTT TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCCTA AAAAAGTCT
G CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG AGATGTGCAC TCAA
GTTGAG TTGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC TTGTAGGTGA
ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGACAGCAT CGCAT
CTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA GTTTGTTTGC ATCTCCAGCA ATACGTTTCC
CAAGGTAACC AAGTTCCCAA GCTCTTCAAT AGTTCTTTTT ATCTTAAAAT AAAATAAAAA CAAAGA
CTGT ACCTTCACAT GTGGGCTTCT CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGAGCCTTTT G
GATCCCTTC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCA
GAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GC
TGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT TTGTTGAG
TG AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CCCTGGACAA ATG
GGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATT AAAAGACTA
A TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATTATGGTCC AAGG
AAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT ATAGATGGTG CCAAAAAGAA
AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTTGCAG TTTGGTTTTT GTGTTATGTT TTGCT
ACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTT
GTTTTCAATA TCCTTGCTCT CACTTTAAAG TGAATTAAAA TTTACTGCTT ATATATGCAT CAATAC
TATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCATTTCAGA A
GACAGGTGT GATGAGAGTT TTACATTCAA ATCATGTTCT CATTATTCTG CTTTCCGAAT TTTCTAA
TAT GATTCCTTTA GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TTTTATCAGC AC
ATCACAGT TAAAAAAAAA CAGCAAAGAA TTCATTCTTA ACACATATGA TCCTTTCCCT GGCCAAAC
AT TAGTTCTTTT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTCTATAG TTA
AAGTGGG TATTGGTTTT TTTTTTCACT GTCCAAGTTT GAAGATGGTT GTTCTTTAAG AAAGTATAA
A TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT GCCCTTGAGT GGTG
CATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTTGCA GGATGATTTG
AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCATTCTG AGGCTGGCGG ACGGC
CCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG ATATTAGCAC GGCCTAGAAT TAGCTTGCCC
ATTTCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTT
ACAC GTTGGCTTCT CGTTGTCCCA ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATT A
GTTCAAATC CTTCTTCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGGG TTTTGGA
AAC ATTCCACGAA CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT GAGGATTTTA AA
GAGCACCA TGAATTTTAC AGAAGAATGA TCTTTTCACT TCCTATTGAG CTGGGTGCCT AACAGAGT
GA GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GACATGCACA GCC
AGAATAA AAGCTTTTAT TCTTTTTCAT GGATATTCTA TCTTTTCTGA TTTCCACTTT GCCTATGCT
G AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA AATAGATTCC AGAT
TAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT TAGCCCATCA GAGCCTGAAG
AACTGATTTT TCTTTTTTTG GCCTCTGGTT CAGAAAGATA AAATTAAGAG AGAAAAAGAG ATACT
AAGAC TGCTTGACTA TCATGGTCTT AAGTTAGTCC CATGGCTTGG AAAAGTTAAA CAGGGAAACA
AGATGAGAAA TCCATTGAGA TTTCTAGAGC TTTATTGTTT TATGGTCTCC CTTACAAATC ACCAGA
GCCT CAGAAACACC CATTTCAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG G
TTGGCAATA TACATTGGCT GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAAA CTTTCCC
TGA AGTTTTGAAA ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG TT
CTGTGCAT TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTCTCC AGAGGACA
TA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA GAA
TTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGGAT TCCAGGGCT
G TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA CCTTTAACAG ATAA
GAACAC TGGAAACTAG AACTACAGTT TGGTTTTTTT TTTTTTTAGT TTAAAAATTT ATAAAATTTC
TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTTTT CTTTTATTCA AGAAAATGCT GATCC
ATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT GATATGGGGA
GAGTAGTGTA ATTGTGTTTA CCTCAAAACT GTTCAAATTA TATGAACAAA CACAGCAAAC TTAGGT
ACCA CAACAAATTT CTTGTTACTT TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCTTCCAACC A
GGATGAGAA CCATTCACAA AGCTATATTT CAAATTTAAG TACTAGAATA CATTACAAAT TTTAAAA
CCC TAATGCTGCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTTAAACTTG AA
TTCGTTGA AATCAAATAA CATTTAAAAT TCAGTTCCTC AGTGTCACCA GCCACATTTC AAGTACTC
AA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TTTCCATTAT CAC
AAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT CTCTTAATG
T ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC TACACGGCTA GTCA
TTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCACT CATTTCTACT
GCAACGTCTT GTTACCACCT AGATGAGGTG AGTACATGTT CCTCGCAGGG ACACAGAATT ACAGT
TTATT GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGTTC ACACTATTAT
TATCCTCATT TTACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG TCAAGGTGCC AAAATA
AATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGACTT CATAGTCTCA GCTCACGATC A
CCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGAC
GTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGCTCACAC TT
GAGTCCAC TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACACAT TCACCGTG
GC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT ATT
ACTGTGC TTATACTGAG TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACAGAGACAT CAGCAGTCC
T ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG AGTTTCAGGC CCAC
CTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAAT TTACTTCTTC
ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG TAATTAAAAT ATGTATTGTG TGTGT
GCATT TTTATATGTA AAGAACTACA TATTTGCCTA CAGTATTTAT ATATATTTTA TATATATACA
TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCT
ATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC A
TATCCACAT ATTCTTGCCC ACATTCACAC AAAACAGCAA AAGAGAGAAA CTTTAGCAGT TAAACAG
AAT CTTTTGGAAC ATAAAATGAC CACAATAGAG AGCAGTTTTT GCATGCTGTA AATTTGCCAA GA
TGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAG
CT TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC TTTTTCTCTC TTGATGTAGA TCT
CCACGCA GTCCTCATCT TTTTGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTTGG CTTCTTCTG
T CAGAGGTTTC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACTTTTCTGA TTCCAATCCA GTAA
TAACTT GGTGAATAGC TCAATATGGA GTTTAGGTAC TCAATCTCTT CTTTGTTTTG AATTGCAACC
AGGTGTGTGT ACCTTTGCTG ACAATAAGCA CTGGCCTCAT CATAAGTCAT AGCTTCCGTG GAGGT
GTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA GCACTAGTGG GAGAAAAAGA AAAGAAATGG
TAGAGTTTGG TACTGTTGTG GTTTAACTCT GACAACTGTG CTTTTTATTG TCTTATTTTT GGCAAT
GTTT GTGACATGGC CCAGACTTTT CTCATCTTTT CAAAAGTAAG AAGTACGTAT GAAGAAACAG C
GACTTATTG TTTATCTCTT TTGTGACTGC CACCCACTAG GTACCTTATC CACACTCACT CACAACA
TTA TAGTATACCC ATTTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAGCACTTA GT
ATGCACCA AGAAGCACTG TATGAGGTAC TTTCCATGAA CCATGCTATT GAATCCTCAC AATGCATC
TG GGAAATAGGT CATTATGATC CACACTTTAC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA AGT
AAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGCCA GATATCCTG
T GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG TGCGAGAATG AGAA
ATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG CAATCATGAC
TTCAAGAGTT CTTTTCACCC AAAGGTTTAG GCTTGAAATA CTTTCCTGGG GAGATAAAAC ACAAA
ATGAA TTAAAGAAGG AAATCGTGGG TAGCTAGTTA CATTATTCTA CCATGATGTT TAAGGCAGCA
TCCTAAGATT TTGGGCAAAG GACACTAGTG CAATAATCTT TATTTCAGAG TTTAATCAAA TAAATA
AACA AATTTTAAGA CTTTCATTAT TTAGGTCAAA GAGAAAAGAC AGGTTTTAGC TACAATACAA T
AAGAGCTTG TACAGATGTG GTTTTTATTA GAAGGCCTTT TGCATATCTG TGTTTCATGG CCCGAGG
CTG CCCTTATAAA GCGTTCTGCA CTTACCGTTT TGGGAAGCAG TTGTTCAAAC ACAGGATCTC TC
AGGTGGGT ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC AGCCAAGA
AC AGCTGAACAC TACTTCGGCT GAGGCCCTTT TATAGGAGGG ATTGCTTCCT GTGAATAATA GGA
GGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTTTCCC GGGAATATC
C ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC TTGAAGCTAC TTCACCTTTG TCCA
TGCCTT TATATCGTAT ATGCAATTTT ATTAATATGA CAAAAATGCA TGATTTTTAA TTATAATAAC
ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG TTAGTAGTGT CTCTCATGTA GTTGT
GGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC AAGAATAGGT TTGTCATCCA TAGTCTACTA
CCTTCAATTT CTCATTCATA GCTGTGGATA ACCAATCACT ACTCATTTTT TCTTCCTTTT TCACCT
GCCA ATTCAACATA TTTAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATTAAT C
TTCAGATTT TGCACGGCAG TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATATCTAA CACTCAA
ATG GTTAAAATAA TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT ACATCTGGGA AA
GTTTCATG GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATC
CC ACCACTTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GACCAGCCTG ACC
AACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC ATGCCTGTA
A TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG TGGAGGTTGC AGTG
AGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTAA AAAAAAAAAA
AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTTAATTGG TCAAA
ATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA AGAATAAAAA TTCTTCCACA ATGTTAACAG
TGACTAACTC TGGATGGCAG GATTTGGGAT AATTTTTATA TCCTTCATTA TTATTTTCAG GATTTT
AAAG TTTTTTTCAA TTTCCCTTTT TTTCACCTTT ATAGTAACAA GAATACAGTT TAAAGAAACT T
GTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG TGGGTGG
ATC ACCTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AA
ATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCA
AG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTGCACTC CAG
CCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAAT
T TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCTTCATTTT GACA
TTTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG ATGGTAACAG
TAAATGGGGA TCATTTTAAT TTCCATATTC TGTAGGTTTT CAGAGCTCAA GTCAAGCTAA TATTC
TATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG
TAGTGGTAAA AGCCTCGTTT TTCTCTTTAC TTGTTAGCAC TGGTCTTTCT GTGTTCATAA AGATGT
CAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATTCCAAA AAAGACAACT GATTAGAAAA A
AATAACTTA ATTAACGAAT TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATTCCCT CCACCTT
ACC ACTCTCTTAC ATGATCCAGA TACTGACATT ATTCCAATTC TTTATCCCAC TTTACTTAGC TC
AATGTGGT TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTATTTA GATTTTAG
GG CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTTTTAA TAAAGTATGA ATA
CATAATC TGCTATTTTT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA AAACAATTT
A TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG TCGTTAACAT CCCT
AGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA GTTTATCTCT TCCCCTTTTT
AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTTTC TATTTTACTT ACATA
TATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TTTATTGAGT GCTTACTATG TGCCAGGCCA
TATTCTGAGC ATTTTGTATG TTCACCTATT GATTATTCAA TCCGTACAAC AGCCTATGAA ATAGGT
ACTC CTATTATCCC CATTTTACAG ATGAGGAAAT TGAGAATCTG GGGATTTTAT CTCATTCAAA A
GCACAGAGC TAAGGGTTGA AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTACCTGC TACTCCA
AAC CATGATTTCT TTTGTTGTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT TCCTGTACTC TT
CTTGCCCT CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGG
GT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG TGA
GAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC AAGCAAGGC
A GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA GTTCCTGATT CAAA
AGCAAA TTTTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT CTAAACTGAT TATTTCTAAA
TTGAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTGGAA GAGAT
AGGTG AGTAACAGTA ACTTAAATGT AGACTATATA TAATATATAA TATATGTAGA GTATATATAT
ATAATTACAA TATATTATAT ATGTGGAATA TATATATTAT TTATATATAT TTATATATTT TATATA
TATA GATATTTTTA TATTTTATAT ATAAATATAG ATATTTTTAT ATTTTATATA TAAATATAGA T
ATTTTTATA TATATTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACC
TCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTTC CT
TTTGTTCC CAAATACCTG TAATTTCACA TGCTTACTTT ATCTTATATA AAATGTAGAT GTACTGAG
CA TGAGATCCAT GCATAATTTC CCTCTAGTCC CTTCTTTTTA CATGTAAAGT GTAGACTCAC TGA
GTGTTAC AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTTCG TTTATTTTC
T TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCTTTGGAAA AAGC
GCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC AAAATAAACC TCTAATCTGT
TGAGATATGC TTCAGTTACT TTTTGGTTTA CAATATGTAC ATGTATGTAT ATAATTTATA TGTAT
ATAAT ATATGTACTT GTTTTAACCA GAGGTATGTT ATTCAAAATC CATTCATCCT TACAATTACC
TGCATTCTCC CACAGTATTT TCTGTGTCCC TGCCCCCGAG GTTGTCACTG CAAATCAGGT ACATGG
ATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC A
GCTTTCCTC TCGTGGAGAG GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCAG ACTATAG
CTT CTTCACCTGC TTTTTCCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT TTTGAGGGTG GG
GGCAAATC AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTTGAATAGT TGGGCATGTT GAATATTA
TG AATATCATCT CCCTCTTCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGATTAGAG GTG
CTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT TGCCGGTTT
T CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG CATCCGCTAC ATAG
ATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG CCACCAGTGC
TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT CTCTTCCTGG AAGTCTCTTG TCCTC
TCCTC CACACCCTTT AATCAGGCAT CAAAGACTTT AACCAGTTTT GCTGTGTGCC CAGGCCCACT
CATTCTCACT TTTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGATT GGGGAC
CCCA AGACAAATGT TAGAATTTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGTTTAGT G
GAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTTGGT
GAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGTTCCCTT AC
CTCTGCGA AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCCTCT CTCCCATA
AA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AGGGAGGAAA TCC
CAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTTCTT GCATTCCCAA AATTGTGAA
A GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA CCTAAATATA TTTG
ATGAAA ATGTGTCTGG TTCTAAGTTT ATTTCCCAGA AAGCCATGTT TACTCACTTG GAATTTATAG
ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTTTCTCCCA CACCC
AGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA AGAGGAATCA CCTGGACAAC TCACCTAAAA
TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTT
GGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA C
ACTTAGATG TATTGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTG
CTC AGCTATAGGT ACCAGAATTT TGATCAAAAT TTACTATCAT TGTGACACTT CTCTTCGGAA CT
GGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATT
TT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA GAG
AATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTTTTCTCCT CTGATTCCA
G AGGACTTTGT AATTCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG ACTTGAATTT TTCA
TGTGCT TTTTGCTTCC TATTTGGCAG CATCTTATCT TGAAGTTTCC GCTTTCTGCT TGGGGACCTA
AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAAAGCGGA AGAAA
CAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT TTCCTGAATG TAGCCAGACT GTTTGCCGAC
TGTTGTTAAC ATGAGGGAAG AAATACCCCT GGATTTTAGA AGAGCCCCTT GTTTGTTTTC CTTGGC
CATT TGTGCTGCTT GTTTTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC TTTGTTCTCA C
GTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTTGGATTTT ACTGTATTAG AAAATGT
AAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTTTTTTTCT TC
CCCAAATC TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTAGAT CTCTTTAG
AG CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGATTAAC CGG
ATAACAA TGAATATTTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTGTA ATCCCAGCA
T TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATG
GTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT GGTGCAAGAC TGTAATCCCA
GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTGCAGTGA GCCAA
GATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA GCGAAATTCC ATCTCAATAA ATAAATAAAT
AAATACAGTG ATTTAACACA AGAGATTTCT ATTTCACACT AATGAGCTCT GTCACTGGGG CAAGCT
TCTT TGCCTCATTA AGTCTCAGAT TTCCCGAGAG CTTATTTATT TATACCAAGA GTGCTTTACT A
CCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATTTATA
TCA AAGCGTTCTT CGTTTTTCCT TGCTGTGAAG TTTTTAGCTA ATAATTCATA AGAATATACC AT
ATTTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT TTTACAAA
GT GAAAGGTAGA TATTAATCTC ATTTTATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT AAC
TTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC TAAAGTCCG
T GTCCTTTTTA TTGGCTCCAT GCCTACTCAG ATTTAAATCT CAGCAGGGAA GTAAACCTTA GTTT
TTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC CATCCCAGTT TCACGAGCTT
AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCAGTC ATTTA
TTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA
CTCCACAAGA AGTGTGTTAA TAAGCAGGTT ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAA
CAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG G
TATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAATT CCTCTGC
ACT TTCAAGTGGA TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCTTGTATT TA
AATCTGAC ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTTTCTGTC ATTACTGT
AA CAGATTACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTTTGTGT GGG
TCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTTTCAC ATTGCCAATA TCAAGGTGT
C ATCCAGTTGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTTCAAGC TCATTCAGAT TGTT
GGCAGA ATCCAGTTCC TTGTGGTTGC AGGACCAAGG TCCCTGTTGC CTTGCTGGCT GTTGGCCAGG
AGTCATTCTT AGCTTCTAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC ACTTCACCTT TCAAA
CCAGC AGCGGCTAGT CGAGTCCCTC TCTTCAAATG TCTCCAACTG TGCCTTCACC TCATTTCTCC
TCTGTGTACC ATGTCTGCCT CTACTGCTTG TAAGGGCTCA TGGGATTACA TTGGATTTAT TCAATC
CAGG ATAATCTCCA TATTTTAAGG CTAGCTGACT AGTGATCTTA ATTCCATCTA CAAAGTCCCT T
CCAATAGTA CTGTATTAGT CCATTTTCAT GCTACTGATA AAGACATACC CAAGACTGGG CAATTCA
CAA AAGAAAGAGG TTTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC ACAATCATGG CA
GAAGTCAA GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGAGAG CTTGTGCA
GG GAACTCCTCT TTTTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CAAGAACAGC ATG
GGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA GGAATTCAA
G ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA TGTTTGATTA AACA
ACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC TGCCCACCAA GGCTGGGCGC
GGTGGCTCAC ACCTGTAATC CCAGCACTTT GGGAGGCCAA GGTGGGTGGA TCATGAGGTC AAGAG
ATCGA GACCACCCTG GCCATGGTGA AACCCCATTT CTACTAAAAA TACAAAAATT AGCCAGGTAT
GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCACTTGAAC CCAGGA
AGCG GAGGTTGCAG TGAGCCAAGA TTGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT G
TCTCAAAAA AAAAGAATTC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAATTAG
GTG AATGGCTAAC CTAAATTAGC ACTGTGATGT GTTTTCTGAC TTGGTCCTTA TAGCTCCTCT GC
TTAGATGT GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTTA AGTGGGAGTT AAATATCC
AA AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TTTCTTGGAT AAC
CCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTCCC ATAAATAGA
C ATTTCATTTT GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC AGTTATCATT AATT
GGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG TCATTTGATC ATCATAATAT
GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA GGCACTGAGG GTTAGAGTTT AAATA
ACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT CCATCTGACT
CCAAAGTCTA TGTTCTTGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGTTTTACT ACTATA
TTCA CACTCTACTA ACTTTACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGCACAG A
AAACACATG AATGCAAAAT AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAATACC TGATGTT
TGC TCTAATCCAG TTTTACTATT AATTAGTTGC TGGTGCCCAA GTTTTTACTG AGAAATGGGG AT
AATTTTGG AAGTCATAAT GATGCCTTCT TCTCATAGGG TATTTTATTT GTTGTTGTAT CTCCAGGC
CC CAACACAGCC TGGCTTTTAG TAAATGATCA AAAATACCTG TTGAATGAAT AAATGGAGTC ACC
TGAAACA TGTTAAACAT TTGTTCATGT GTCCTAATCG TGGATTTCAG GATAGTAAGC ATCCTAAAA
G GAAAGCATGC ACACTGTTCT TGCTACATTA ATTTCTCACA ATATAAAAAA AGAAAAGCAT CTGA
AAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGAA GCTAAGGGAG
AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA GTCCTGGGGG TCAGACCCGA GGAGA
GCAGG AAGTGTCTTT TGAGGGATAC ATTTCCACAG TGGAAATAAT GAGACTTAAA TAAATATTAT
ATACACAGTT CAACTGTTTT TATGTGTAAA GGTAGTAGGT TTTCACAGTA AGGAAGCACT TCTTTT
TTTT TTTGTTTGAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG C
TCACTGCAA TCTCTGCCTC CTGGATTCAA GTGATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGAC
AAC AGGTGTGTGC CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC GGTTTCACCA TG
TTGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGTT CTGCCCGCCT CTGCCTCCCA ATGTGCTG
GG ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TACAAACCCT TCT
TAGAATA TTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTTCCCAA CTAATACTAG GAGGTTATA
A CCTTCATACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGCCACCTAG AAGG
AAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC GGCATGGCCT
GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCAAG
GTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT GTTACACAGG TTGAAAAGCT AAGGTTTATG
TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGA
AAGG AACTGTGGAA GATTTTGGGC TGAATTTCAA AACAGAATTT CCTCACTCTC TGGATGTTGG C
TTACTTGGC CTTTGATGTT CAGAGGTGGT GCCTTTGTGT TGTTGAACAA TGTTGATTTT GGAGAGA
AAA CAGAGTTGAA AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC AGAGGATAAT TT
CAGCAAGC CAGCAAGGCC TCATCTCTGC TTCTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATAC
TT TTTTAAGAAG CTCAGCTTTA TCGCCTTATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC TAA
AGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGTTTCCCT TCATTAAGA
G AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC TGTAACCCCT GCTA
CTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCACTTGC CTCCCTGGAA
TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT TCTTAGTCTA ATAGACTAAG GGTCT
CTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GTAGTCATGC
AAATCTGCAA AACAAACAAA AAAGTCTGGG TATTGCTGCT AACTAGCTAT GTGACCTTAA GCAAGG
TATT AACTCTCTCT GAATTTCAGG TTCTTCATCT GTTAAATAGC ATATCTGTAA AATGGGAATT A
TTTTCATAT CATAATGCTG TAGCTTTAAA AAATAAAATA AAATGGATGA GATAATCAGA ATTAAAG
AGC CTGGGATATA TAGTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATTTTA CA
GTTAACCA TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATTTG CCTGTCCT
TC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA TGG
GTGGGAA ATTTCTAGGC TAGTATTGAG AAGCCCATTT CTTGGGAAAT AGGTCCTGGA CTGAGTGAA
G GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAGAGGA TGAA
TTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTTTA CCTTCTTGTG AAATGGATTC AAAGATTCAA
AGACCTTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG CTGTATGTTC CATGGAACAC TACTT
CCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTT TGGAAACACT CCATTATGTG
GCCACCTCCT TGAAGACTCT AATGCACATT AGCATGTTAA ACAGTCTTGA GAAGTCCTGC AGAGCA
GAAA TTGCTTCACA TCTGCTAAGC CGGCAGTTTC CCAATATACT TGATTATGGA TAGTTTTTTC C
TTACAACAC CATTCTCTGA TATGCTTCCA ATGACATGAA ATAAATATAT ATGCATGAGG TTCTTCA
TTA GGGCATACTT TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTTAC CT
TTTCTGCA TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGTTT GGTTCCCACA ATATCTCC
AA AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTT TTTGGTTTCC CAA
TGTATAT CAAAGTTACA TTTTTACTAT ACCATAGTCT ATTATATATA CAATAGCATT ATATCTAAA
A AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATTTTCTACC CAGACCACTA AAAC
TTTCTT CATATCAGCA ATAAGGCTGT TTCACTTTCT TACTATTTTT TGTGATAGCA CTTTTCCTTT
CCTTCAAGAA TTTTTCCTTT CTATTCACAA TTTGTTTGAT ACAAGAGGAC TAGATTTTAG CTTAT
CTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT GCTAATGATC ATCTGAGACT TCAGCAAGTC
ATAATCTTTT GCTGGTGGAA GGTCTTGCCT CAGTGTTGAT GTCTGCTGAC TGGGTGGCTT TGGCAA
TTTC TTAAAGTAAG ACAACAATCA AGTTTGACAT ATCAATTGAC CCTTCCTGTC ATAAATGATT T
TTTTTTTCT CTGTAGCCTG CAATGCTCTT TGATAGCATT TTACCCACAG TAGAATTTTC AAAATTG
GAG TCAATCCTTT CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA TTAGAAATCC CT
TGTTGTCA TTTCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA AACCACTT
TC TTTGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TTTATCCTGA GATTGCAACA ATT
CAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTCAT TTGTGCTTA
C TTTCTCCGCT GAAGTCTTGA ACCCCTTAAA GTCACTCATG AGGGTTGGAA TCAACTTCTT ACAA
ACTCCT GTTGATGTTG ATATTTTGAC CTGCTCCCAT GATTCATGGG TATTCTTAAT GGCATCTAGA
ATGGTGAACG TTTTCAGAAG GTTTTCAGTT GGCTTTGCCC GGATCCATCA GACGAATCCC TATCT
ATGGA AGCTATAGAT TTATAAAATG TATTTCTTTT TTTGTGGGGG CATAGCGTCT CACCCTGTCA
CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGAT
TCTT CCACCTTGGC CTCCCAAAAC ACTGGATTAC AAGCTTGAGC CACTGTGTCT AGCCCAAAAT G
TATATCATA ACTAATGAGG CTTGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTACAGA ATGGACG
CTG GGTTACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTCCTGGGT GA
GCAGGCCC ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTTTTT TCTGAGCAGT AGATCTCC
AC AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT GTT
TTTCCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA TAATTCTCTA GGGCCTTAGG ATTTTTGGA
A TGGCAAATTG AGCATTGGCT TCAACTTTTT TTTTTTTTTT TTTTTTTGAG ACAGAGTCTT GGTC
TGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTAGGTTCAC
ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATGCCC GGCTA
ATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA TGTTAGCCAG GATGGTCTCG ATCTCCTGAC
CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGC
CTGT CTTCAACTTA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCCTTTCA A
GCTTTGAAG CCAGGCATCA TTCTCTTCTC TAGCTATGAA AATCTTAGAT AGCATCTTCT CCCAATA
GGA AGCCATTTTT TATGCCCTAA AAATCTGTCG TTTGGTGTAG CCACCTTCAT CATTGATCTT AC
CTAGATCC GCTGGATAAC TTACCACAGT GTCTACATCA TTACTTCTGC TTCACCTTGC ACTTTTAT
GT TATGGGGATG GCTCCTTTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACATTCTT CTT
TTACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATGTT GGGCCTTGGA TTACACTTT
G GTTTAAGGGA ATGCTGTGGC TGGTTTGATT TTCTATCCAG AACACTAAAA CTTTCTTCAT ATCA
GCAATA AGACTGTTTC ACTTTCTTAC TATTTTTTGT GATAGCACTT TTCCTTTCCT TCAAGAATTT
TTCCTTTCTA TTCACAATTT GACCGTTTGA TATGAGAGGC CTAGATTTTA GCCAATCTCA GTTTA
CACCA TGCCTTTTTC ACTAAGCTTC ATCATTTTAG CTTTTTATTT AAAGTAAGAT GTGTGACCCT
TCCTTTCATT TGAACACTTA CATGATGATG CCTGGCTTCA AAGCTTGAAA GGACAGGCAG ACTCTC
TTAT TAGGGGCTAA CACAGCTGGC GACTTTTAAG TTGAAGCCAA TGCTCAATTT GCCATTAGAA G
CCATTGTAG GGTTAATTAA TTTGCCTAAT TTTAATATTA TGGTGTCTCA GGGAATAAGG AGGCCTG
AGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA GT
TTATCACC TTGAGGGCAC AGGTCATGAT ACTTCAAAAC AATTACAATA ATAAAATAAA AAATCATT
GA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TGAGAATTAC CAA
AACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGA CTTACTTCA
T GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA GTACCATAAA AACA
AGGTAT ACCTGTTTAT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCACT CCCTAGCTCG
GAGACATTCT AACCAACATA CACTTACCTT TCTTTTTGCT GTGTACAGAA TTCAAATCCC TGTCT
CAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA TGTTAAGTCT
TGTAAGCCCA GAGACCACTG TATATACAAG TGTTGCTATA AGCATTAGTT CTTCTCCAAA GAAAAT
AGTC CACTTGGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATTTT TTACAAGAAG A
TTCAGTCTC TTACCTACAT AAGCAAAAAT ATGAGATGTT CTCTTATCAT TTTTCCATCT ATCTTAT
AAT CTTTGGTGCT GACTTAGACA CTCATTTTCC TTTTTGTACG TGACCATGTA AAAGTTCAAG TC
AAGAAAAA CTTGTTTTGA CATTTGTTTT GCTGAGTGAT GGGTCCCTAA AAGAAATTTG GCTTTGCT
TT TGAAAAGTTC AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AGAACAGTTG TGA
TGTGTTT AGGTGTTTTA AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA AATGAAAGA
A TATGAAGGAA AGCCTTCTTG TCTTAGAACA CACTGATTCA CAAATAAGCA GCTTCTCTCA AAAT
GTTGTA ATTACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAACTT
AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT ATATATATAC AAATTGTGGA AGCAG
GGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACTGTTTAA AAGGGAGGGT ATCCTTGAAA
GCTTGACACT TGACTCTTTT GACGAGGCTG AGGGAAAACA CTCAGTTTCA TAGATTGCTG GTACGG
ATGT AAAATAGTGA CATCCCTATA GAGAGGAATT TGGCAATATC TAGCAAAAGT GCTTATGCAT T
TATTCTTTG ACCTAGTAAT CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATA
TAT ATACATTAGG TTATTAGTTA TGGTTTAATT TTTAATAGCA AAATATTTAA AACAACCTAC AT
GAACAAAT AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATT CACTTATG
TT GTTAATTTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TTAGTATAAG AAA
GGGGAAA TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAGGA TAAGTAAGA
A ACTAGTAAAA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG AATTAGGCTT CTTT
GAGTAT ATGTTTATAT ATAGTTTTGA CTTTTGAATT ATGTTTATGT TTACATAGTC AAAAATATAA
ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CTTTAAAATT TAATACAAAC AGAAA
TAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TAATCCAACA
TACCAGTGGA ACACAATATT CTAACTGTAT ACATTCAGTG GTTATAGTCT AAGGACAAGA AAAATT
GCAA AAATATCTTG AACTTTAGCT TGTAGGATTT TTATTGGTAG CAATACTAAT GTACTAATTC T
GAAATTAAT GTTCGTGTAT TATAGAATTG AGTAAATGAA TAAATATGTT GATGTTATTG GGAACTA
AAA TTATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTTGG CAAATGAAAC AAAGACCTGC AG
AGAGATAA CCATATAAAC TCATTATTTT AAAAATTATA AGTGTCCTAG CTCTGTTACT GAAAAGGC
CT AGATTCAATC TTATCTTGAT AGACAGGAGG GCACCCCTTT CTCAGAACAT GGTTTCCAAA TGC
CATTCTC CATTAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCTGG ATTAGGTAA
A GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA AGAAAGTGCT CAAAAACATG GGAA
CATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA TTTAGGACAA TCGAGCATCA
AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT AAAACAAAAA ATAATCCATA GCCCA
CAGAA GGGGAAGAGA GGGGGAGCTC TTATTTACAG ATGAATATCA AATAGCAAAG ACAGAAGAAA
TGACAGAATT AGAGAAACAT CATTTTGCAA AACACCACTG TAATAATCAA TTCAGGCAAG TATTAT
TAAT GGATGTATTA CTATTGCGTA AAACCAGTTG GGGAACAGGA TATTCATACA GTCTGAAGGT G
TCACCCTAA ACATAACTTA TTACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCTA GCAGAAA
CCA TCTTAATCTA GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CC
TAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTATTCTT TTGTATTCAA CAGACCAC
CC AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTAATT CATTTTGGAT TTT
AAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATCTTTT ATTCAATAC
T TTAGCTTGGA GAACCATTCA GAGTTTCTAA CTCATTGTAT TGCCAAAAAT AGAAAACAGC ATGG
TTTCTT TTGAAAATGT CTAACTTTAA AGTTACTTGT GTGTGTCACT CAGATTCACA TAGCTTTTTT
GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TTTACAATCT TTTATTTAAT ATGAC
TCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC AAAGCATAGC
AATTTGATTT GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATTACA GGAATCATTT ATGAAG
CAAA CACTAAAATA TTTATTGTGA AGATTATGAG AACATAGAAG ACAGTTATGA GAGTAAATTT G
AAAACCTGA ACACAAAACT TACATATACT CCAATTGTAA CTTATAAAAA ATACGTGCAT ATAAGGA
TAA AACAGTACAA ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC CTTTTGCTGT CT
TAATTTTT TCCTTTTACA TTTTGATACA TTATTTTAAT TTTAATTTTA AAATTCAAAA GAATTTGC
CA CTCATCTTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA TTATTCTGTT CTTAGTATAG TTT
TGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATAAG ACAATATAA
A ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC ATTATGGACT TTTT
TTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT GGCAGCACCA
ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG CAGACAGTTA GCTGAGAATT CAAGA
GCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC ACCTTTCCAC CCACGTTTCC CTGTTCTGTT
GTACTCTGCT TACCCTTTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TTGCTCTTAG TCATTC
ACTA TGTTGTTTAA TCTGCCTTCC ATCTTTCTTA TCAGTTCAAA TTAGAATGTA GACCTGAATT T
AAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTCA GAGAACA
TTC TTCATTTGTA GAATGGGAAG ATTAATCTAT ATTCCACTTG GATGGCAAGT CTTTTATAAA CT
TTATAACC TAAACATGTG TGAGTTGCTA GTATCATTAT GTTGGTAAAG TTATTCTGAG ATATGATA
AC AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTT AGAGAGTGTG GAATTAAAAG GCT
TTATCCT CAAATATGAC TTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAACAA ATCCTCAGG
A AATGACAAAC TTTACATGGT TAAACATCAG TTTTGTTTAG TCTTTGACAT CCACATGGTT AAAT
CATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT GAAAAGACTT ATTGAGGAAT
AGAAGACTAC ACATTTTTCA GCAAACACTG CACGTTTTGC AGAATTTCCC CAGGCACCAG TCTCC
AGGAA TTTATTGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATCTT
GCAAGTTTTG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGTTGTG AAATATTAGT ACAAGT
AAAA ATTATTTACA ATGAAAGACA TTTTGTCAAT AGCTATGAGA ATTTTACCAT TGACCCAGAA A
TTCCATTTC TTTCTTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TATTCATTAC AGTATCG
TTT TTCATAGGAA AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GA
AATCAAAT GACTAAAAAT GTTAATATAA GCATATGTTT TTAAATTAAC TTGGCTTGGG TCTTCAGC
AA AATTGGCTTC TTAACATTGC ACTCCAGAGT TAGACTTACC CACTCAGTCA CTTATCATGC AGG
AGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAAT
C CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT GAACTCTGCA ATGT
ACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA TCATAATAAC ACAACGGCTT
TGTTTTGTTT TTGTTTTTGT TTTTTGACAC GGAGTTTTGC TCTTGTTGTC CAGGCTGGAG TGCAA
TGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC TGGGTTCAAG TGATTCTCCT GCCTCAGCCT
CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAATTTTG TATTTTTAGT AGAGAC
GAGG TTTCTCCACG TTGGCCAGGC TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACCCGTCTTG G
CCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTTT TGTTTAC
ATC TCTAGTGCAG CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTTCAT CTTTTTATTT TA
TACAGCAA TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAAT
AA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATATTGA CAT
CATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTTTTG GAATATAGAA AATCTGGAT
T ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG TTCCACATGT TTCT
GAGGCT GTTTGTCCTT ACTTTCTTTT CTGTTTTATC CACTCTTTCT GTTCTTTAGA TTGGATCATT
CCTATTGAGC TGACATCAAG TTAACTGACC TTTTATTTTG TCCAAACTGC TGTTAAATGC ATCCA
GTGAA TTTTTAACTT TATATAGTAT ATCTTTTAGT CCTAGAATTT CCACATGAGT TTTTTAAGTT
TCCATTTCTC TGCTGAGATC TCCTATTTGT TCATTCATTA TGACCATATT TTTCTCTACA TTATTG
AGCA TAATTATAAC AGCTCTTCTA AAATTCTTGT CTGCACATTC TAACACCTGA ATTATTCTGG G
GTCAGTCTC TGTTACATTG CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTGTTTC TTAATAT
GCA AAATGATTTT TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA TTCTGGATTC TC
GAGAGAGT ATTGACTTGT TTTTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAACTCC AAACTCTA
GG TCCTCTGTAA TGGGCAACTG CAGTAATCTT TGTTTAGTTC TTTAAGACTT ATTGGCCAGG CAC
GGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG AGGTCAGGA
G TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAAAAATTAG CCGG
GTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAATC ACTTGAACCT
GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT ACTCCAGCCT GGGTGACAAA AGCGA
GACTC CCTCTCAAAA AAAAATTTAT TGGCACTGCT TGGCATCTGC TATGAATACA TGAAGTTCAT
GGGTCAGCTA TAGATCTGGG CACGTTATAC ACAGAATTTG GGTCTCCCTT TCTCTGGATT TCTCCT
TTTC TGGATTTCTT TTCTCATTTT CCAGCAGCTG TGGTTGCCCT AAACTCGGTC CTCTGTTTCT T
TACGGCAGT AAGATTTGGG AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAAAAAA TAATTTT
CAT CTTGATGCTA CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT TGCTTTTTAT TG
CTCTCCAG AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC TACTCCCC
CA AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC TTCTTTGGAA AAG
GATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG TTTTTCTCAT CCGTAATCTT TTTATTTTC
A TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT CAAATGACCC CCAT
ATTACT AAATACAATA TCCCCAACTG CATTTATAAA AAGAAAATTT ACTGTTTATT AGTAAACAAT
GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT TAGAATCCCA GATTC
TAACT TACTAGCTGG TGTATTAGTC CTTTCTCATG CTGCTAATAA AGACATACCC CAGACTGGGA
GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATTGACTCA CAGTTCAGCA TGGCTGGGGA GGCCTT
AGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA AGCCCCTTAT A
AAACCATCT GATCTTATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCAC
GTT TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATAATTCAA GA
TGAGATTT GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCTCATGT
CC TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATTCCA GCA
TTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTGCC TATGAGCCT
A TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC GTTGGGTAAA TACA
CTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAGT CCAAAACCCA
ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC TTTGACTTCA TGTCTCACAT CCAGG
TCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GCTTTGCAGG
GTATAGCCTG CTTCCTGTTT GCTTTTTCAC AGGCTGACAT TGAGTGTCTG TGGCTTTTCC ATGAGT
ATGG TGCAAGCTGT TGGTGGATTT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT G
TAATCCCAG CACTTTGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGC
TAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TG
CCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT GGAGCTTG
CA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA AAA
AAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG CAGTGCCCC
A GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC CCTAGTAGAG GTTC
TCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA GGCATTTCCA TACATCCTCG
GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTCTTGA CTCCTGTGCA CCCACAGGCT CAATA
CCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG AACCCTCTGA AGCAATGGCC TGAGCTGTAC
GTTGACACCT TTTAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCTTCATAA AGTGGG
AGGG CCTTGGGACT AGCTGAGGAA ACCATTTTTC CATCCTAGGC CTCCAGGCCT GTGATGGGAA G
GGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTTT TCCCCATTGT CTTGGTAACT AACATTC
AGC TCCGTGTGCA GCACCAACTT ACTTATGCAA ATTTCTGTCA CTGGTTTGAA TTTCTCCCCA GA
AAACAGGA TTTTTCTTTT CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTTATGC TATGCTTC
CT GTTGAAGACT TTGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TCTCTCTCAA GTT
CAAAGTT CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAAGA GTGACCTTT
A CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG GACTTAGTTG TCCA
TGTTAC TATCAACATT TTGGTCAAAG CCATTCAACA AGTCTCTATG AAGTTTCAAA CTTCCCCATG
TTTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT CTGTCTGTTA CCCAGTTCTA AAGTC
ACTTC TACATTTTTG GGTATCTTTA CAGCAGTGGC ACTCCCCATG GTACTAATTT ACTGTATTAG
TCTGTTCTCA TGCTGCTAAT AAAGACTTAC TCGAGACTGG GTAATTTATA AAGAACAGAG GTTCAA
CTGG CTCACAGTTC AGCATGGCTG GGAGGCCTCA GGAAACTTAC AAACATGGTG GCAGCAAAGA G
AAGTTCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTCA CTATCAT
GAA AATAGCATGA GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC CCTCCCATGA CA
GGTGGGGA TTATGGGAAC TACAATTCAA GATGAGATTT GGGTGGGGAC ACAGCCATAC CATGCCAG
CT AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTTTCCTAT TTGTTCAACA AAA
ATAATGA CACCCCTTTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGCCT TGCATAGTG
T CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT GTAGACTTTA TTTT
TTAGAG TTTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG TTTCCGTATA GCACTCCCTA
CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTACATTTAT TATAA
CTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA AAATCCATAG TTTATATTAG GGATGCCTCT
TGGTGTTGTA CCTTCTATGG GTTTTGACAA ATGTATAATG ACATGTATTC ACCATTACAG TATCAT
AAAG AATAGTTTCA CTGTCCTAAA AATCTTTGAT CTTCTTCCTA TTCATCACTC CCTCCCCATT A
ATCCCTGAC AACTACTGCT AATTTTCCTG TCTCCATTGT TTTGTCTTTT CCTGAATGTC ATATAGT
TTA AATATACAGT ATGTAGGATT TTCAAACTGG TTTATTTCAC TTAGTAATAT GCATTTGATG TT
CTTCCATA TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TAATATTCCA TTGTCTGG
AT GTACTACAGT TTATGTATTC ATTCACCTAT CAAAGAACAC CTTGGTTGCT TCCAAGTTTC AAC
AATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTTTTTTTGT GAATTGAACA TTTTCAGCT
T TTTTAGCTCC ATTCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGTTTAGTGT TGTA
AGAAAC TGCCACGCTC TTCCTAACTG GATGTACTGT TTTGCATTCT CACCAGCAAT GAAAGAGTTC
CTGTTGCTCC ACATACTCAC CAGCATTTGG TGTCGTCAAT GTTTTGAGCA ATAGCATTTT GATCT
AACTT TTCCTAGGTA TTCTTTTTGA AGGAAATAAT ATGACAGATA ATAGAGAAAG GATATACGAG
GACAGTTCTG TCCTTTATTT ATAGTCCATC ATTTAATGAA GGACTCTGTC CACACTTGGT ATTTTT
AACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGTTGCT GGCACACATG G
TTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TTTTTTTTTT TTTTTTTTTT TTTTTTT
GAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GC
TCCGCCTC CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCC
GC CACCACGCCT GGCTAATTTT TTGTATTTTT AGTAGAGGCG GGGTTTCACT GTGTTAGCCA GGA
TGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA TTACAGGCG
T GAGCCACCGC GCCCGGCCTT TTTTTTTTTT TTTTTTTTTT TTTGAGATGG AGTCTGTCAC TCTG
TCACCC AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC CATCTTTCAG GTTCAAGTGA
TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATTACAGGT GCCCGCCACC ACACCCAGCT ATTTT
TTTGT ATTTTTAGTA GAGACGTAGT TTCACCATGT TGGCCAGGCT GGTCTCATTC CTGACCTTGA
GTGATCCACC TGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCATGGGT CATCACATGT GGCCTG
AAGC ATGACTGTTG CTTTAATCAT ATGAAATACT GCTCTGTATT GTTATCTATT TGAAATGCCA C
ACCTCCTGA GCTAAATTGC AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATATTAGC ATGATAC
CAT GACACATATC AAAAGCTGTT ATATATTGTT ACGTGAATTG ATTCTTTCTC AGTTAAGAGG AC
CTCTGTAG TAGCACTTTC ATACCGTTAA TTTTTCATTT TGTGCCCAGC CCCTACTCTG TGAAAAAT
GA AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTGTGGACAA TGTGTGGCTC AAG
AGAAAAT TCAGTCAGTA AATTTGTTCA GTGCACAAAC TCTTTATCAC CTCTCACTGT TCTCAAGTG
A GATAGAACAG AACATCCATC CAGTGTCTTA CAAATTGTCT GGTATATAGT AGGCACTCAA TAAA
TGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT ATGGTAGACA GATCATTGAT
ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA TATGTTACAT TTCATGTCAA AAGGG
ACTTT GCTAATGTGA TTAAGGATTC AGACCCTTGG ATTGTAAGAT TATCCCGGAT TAACCAGGGC
CAATCTAATC ACATGAGACC TTAAAAAAGC AGAAAACATT TCCCAGCTGG GTTAGAGAGA GATGAG
ACAG AGTAAAAAGG AAAGAGATTC AGGGCATGAA AATGACTCTA CCCACTGTTG CTGGCTTTGA A
GATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTTAAGAAA TAGGAAAAAG CCCTCAT
CTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCACTCAAA TG
AGCAAGGA AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC TTGATTTT
AG CCAGGTGAGA CCTGTTTCAG ACTTTTGACC TATGGAAATA TAAGATAATA AAGTTTTATT GTA
TGCTGCT AAATTTGCGG TAGTTTATTA CTGAAGCAAT GGAAAGCCAA TACAGACAGA ATATACAGA
G AGAAAGAGAA TGAGTTCTTT CCTGATAATT TGTAAATATT TGGGTCTTCA CTGGACAAGC TTCA
CAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCTT TCTTAGGCCC
AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGGAAAGAA AAGAT
GGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TCTTTCTCAT
ATGTCCCAGG CTGACTCTTG TGAGTTGTTT TCCCTTGGAG GCTATCGATG ACAGTCACAG TAACCT
GATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACTTCCAA GGACTCTGAT G
TCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTTCCTG AATATAT
TCC CTATTGTTAG GAAGCCAGGT TGGCTTCCTT GCCTACAATT ATGCCAAGCA GTCACACTAT AG
AGTCCCTA GGGACATGAT ATTAAGTGAT TCTTTTAACA CAAACAACTT AATAATCATT TATACTAA
TA GCAAAACGGC CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGGAAGAG AAG
ACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCTG CCTCTGGATT CCCCTTTTC
C TTATATTACC TCTCAGCACT GGCAGGCCTT TATTTCAGGA TACAGTTTCA CAAGTATTAT GTCA
CGTCTC TGAGAATTAT GTTGGTAGAT ATTTGCTCCT CTGGCCAGAA AGACCTAGTT TGGAGTCTGG
AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATG
GCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG CTTATCTCAC
AAGGAACTTG ACAATTTTCT TCAAAAATCC TAGTAGCTAA GATTTCTTAG TAACAAAGCC ACTAAG
GCAC AATTATGATT AACTTGACCC TTAGGTGACT TTTAAGGACT ATTCTATAAA ATATTACAAC T
AATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAATTGACAG TGTCCACACT GGTAAAA
TAA GTTGTTTCAT AAATACATTA GAATTCATTT GCACTTTCTA CACAGCCCCA AGTCCAGAAC TT
TCCCCAGA ATAGGTCTAT GTTTTGCAAT CTGCTACTCC ATACAGAGAT TTGAGTTCAC TTGGCAAT
TT AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AACATTACTA TAC
TTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAAAT CCTTATGTG
A ATATGTAGAT AGTCACAATT GCTGGTTGAT GATGATCTGT CTTTTCCTGT ATTTGAGAAA ATGG
AGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG TGAGAGAGAG AGAGGAATAC
ATGGTGGCTC TCAGTGTCTG GCTTAGGCAG TAAACACTTT CGTTAATAAA GACGGAAAAT AAAAA
AGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA CACTCTGAGT TCCCGGATGT
GAGACATCCA GGCGCATTTA TCCAAGAGGC AGTTGGAAGC AACGTTCCGG AGCTTAGGAG AGAGGC
ATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCATTCTG GAAAACTGTT TGGCAGTTTC T
TAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCCCAGA TAAATGA
AAA AAAAAAAAAG CATTTTTTTT ACACAAAAAC ATATACATGA AAGTTCATAG AAGTGTTATT CA
TAAAAAAC TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG TCTATCCA
TA CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAACACAGA TGA
ATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTATT
T TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTAATGGGTA CTGT
GTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTTG
TGGTTGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGTGATAAA ATTGT
ATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTCCGCAC
ATTGTGCCAA CATCAGTATC CTAGTTTCAA TATCAGACTA CAGTTATACA AAACATTGTC ATTGAG
GGAA ACTGGGTAAA GGGAACACAG GACATTTGGC ATATATTTTT GCAATTTCCT GTGAATCCGT A
ATTATTTAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATGA GTTTACC
TAG TGGATAGCTT TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GC
TCAGAGAA CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCA
GT ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC ATC
CAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCACTC TCCAAGAGA
G AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC ATGCTGTGGC TTGC
ACCTTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT GAGCCCAGGA GTTCAAGGCT
GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAA
CACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TCATTTTACT
GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTTTGACCT AGCCTGAACT GTAGCAAAAG TCATCA
GATA TTTTTCCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAACTACAAC A
AGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATTT
AAA ACTCAACCCA AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAGGAGCTT GA
GTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT CTCCCCAT
TC TTTGATAGGC ATACTTGCTG TTTTCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT AGA
ACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT TTATCAGTT
T CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTATTTACA CAAG
AGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCTTGTG TGTCAACTTG
GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA TTTTG
TAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG ATTGCTCTTG ATAGTATGGG
TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTTTC CCGGAGAGAA AGAAAT
TCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA GCCTAAAGAT T
TGCTAGGCA TTATAATCAC ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATATATTG ATACAAT
GAA TGGTTATAGC AGCCTTATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTTCAA TA
AGTGAATA CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA ATAAATGG
TT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AATGGAAAAA GTC
AGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG GACTAACCT
A TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA GGTATTGTAG AGTA
TCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG AGGGTGATTG ATATGTTCAT
TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATACACTTT TAAAA
TGTTC AGTTTACTGT ATATCTATTA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG
GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATTTTGG AGTTTAGATT TTAAAA
TGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA TTATGAGTCC ACAAAAACCA C
CAGGAAGTC ATGTATGTTT ATACTTTTAA GTGAAGGATC AGTGGATTAT CAACTCCCTA ATGCTTT
GCC TCTCTATGAC TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC CCTTGCTTAA AT
GTAAGCCT TCTTTCCTCC TTTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC TTAAACAG
AA TGTACAGCAT ATTATTTGTA CAATTAAAAA TTTTTGGCCA GGTGTGATGA CTCATGCCTG TAA
TCCCAGC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG AGTTCGAGAC CAGCCTGGC
C AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGTGTGGCAG GTAC
CTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAGG TGGAGGTTGC
TGTGAGCAGA GATCAGACTA TTGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCGGTCCCC AAAAA
AAAAC ACATTTTTTT TTAATGTTTC CTCCTTGCCT GTAGGAAAAA GGCTCTGACT CCTTAGCCTG
GGCATCAGAG CTCTATCTAA ATGGACTTTA ACCTGATTTT GTGGCACTAA TTCCATTGCA GTACTT
GTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT TTTTGGAATA ATGTCCTCTC TCCATCTTGT T
TACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC AGCCCAC
AGA GATATTTAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA CATTTACTTA TA
TATGATCT TGTGATATTT TTTGTTGACG TGTTTACTTT AATTTTCTTC CATAACCTAT TCATTCAA
CA AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATATAGATT ATA
GATATGT TTGAAATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT ATATCTGTG
A TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT CAGGAGAGAT ACGT
GGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC ATTAAAAAAA ATTTTTTTTT
TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAA
CCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG ATTACAGGTA
CCTGCCACAC ATGGATGATA AATATGATCA TATTTTCTTG TTCTTTTCCT CCTCAGTTGT CTTCCC
TGAA GAAAGGAATG CCTTTTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA TTTTTGACCA A
TTTAATTTA ATCAGATGTC TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGATT AGAGACC
AAT TCCCAAACAT GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GG
GCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCTTTT TATTTTTA
TT ACTCTATTAG TCACTACAAC TATTTTCTGA TTGCTATGGT GATAGATGGT TTAAAACAAG CCT
TCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGGTA TTGACAATT
A TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT GAAGACTCCA ATCT
TCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGTG GACTCTAAGC
TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCA
GGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AGTCAAAGCC
AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTTC
TAAA ACCTATGTAG TATCTTGGAC CTTACCCTAA ATGTAATGAG AAGCTTCTAA AGAATCTTTC A
TTTATTCAT TCATTGAACA AATATTTTGA GGCTTTCTGT GAAGAACATC ATTCTAAGTA GTAAAGA
TAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AG
GTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT GATTTCAGAC AATGGTACGT ACTGTGAA
AA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTTTGCA TGG
TTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTA
G GTGTGCAAAG ATGTGGGGAC AGAACTTTTG GACTGAATAG CAAATACAAA TGCCCTTGGG TGCA
AGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAGC ACAGAGGAAA
ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA GATAATATAG TCTCTTATAG GTCAT
AATAA GGCAACCAGA TTTTATTCCA AGAGGATTTA AAAATCACTG GAGGTTTTGC ACTAGGGTGA
GAGGTGTGAT TTGTATTTTT AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACT
AAGT TAGGGGCTAT TTCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG GATAGTAGTC G
TAGAAATAA ATAAAAGTGG CACTCTACTT TGGGGGTAGA GTCTATAATA GGTTTGGTTT ATGGATC
ATA TATGAGAGTA AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTTGTA CCTGAGCAAC TG
AATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTTTTG CAAATTAA
TT TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC ATTGAAAGGT AAG
GGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCAAG GCAGACAGA
T CAGTTGAGCT CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA AATA
TGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CACTTGGGGG GCTGAGATGG
GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGC
TTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATTAA
TCTGATCATT GGCAAATGCA TAGTATTTAA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGA
AGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATTTAG ATGGTTATAA GAGGAATAGA A
ACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCA
TAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCAGTCAAA TA
ATATAAGG ACAGAAAAGT GACCATTGGA TTTGGAAATA TGATGAGCAC TTTGAGTGGA GTGTTGAG
AC AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG CAC
AGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA GACACAGAGT CTTAGCATGT CTTGTCTTT
C TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT TATTCTGCTT TTTGTACCTC TACA
TTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA TTCTTATCGC CTGAATGACT
GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGGATGGAT GGAAG
ACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GAAAGAAGAG
TTTAGATTTT TATTCTTTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAGTCCTT AGATAA
TTTA TGTAATTGTT CACTTAGGAT TTTTAAATGT GATCACTGAT ATTGGACATG TTCCTAGTGA A
GCATTTTTG GTGTTTCACT GGTTGAAGTT AATAACTGTA AAATTATTTC CCGTTCAGGA CAGAAAA
ACA GAAAACTTGA AGCTCCTATT AGAAAGTTCA AGATTCTCTG GGGTTCTTAG GATTTACTGT TC
CCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG TGGAAAGA
CA ATTCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTTCCATA GGAATCAAAC AATAGCTTTC AGT
GACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC TTCCAACCTC ATGGCTGTTG TACCTTACC
T TTCGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAACTT ACCAAGGACT AACCAGCCTC TGGG
GAATTG CTGTATACTT AGCAAACTTA CAATGGACAT ATTTATAAGC CATAATGATA ACTGACTAAT
AGGAAATACC CTCAACTGAA AATGAGAGAT CATCATTTGC AAATGAGTTC CCTTGCCCAG GCAAC
TACTG GGGAAAATGT CATGCAAGCA AAATTAATCT TTGAAATCCT CCTTTTCCAT TTTTTGTGTC
TTCCTTTTCC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTG
ATTT GATAAACTGA TTTATATTGT GTCCAAATGT GATTGTATTT TCAAAGATAA CCTAAGGGGA G
AATGCTGTC TGGCCCAACA GCAGGCTCTC GACTTCATTT CAGACACTGT GGCCAATGGC TGGGAAA
CAG GTATGAACAG TAGGTTTCTG AGTCCCCTGG AATTATTCCA TTTATGTAGC CACCTCCATG AC
AGGAAGCC TCCCTACTCT TACTTCCCAG TTTGTTCATT CATGGCACCA GGTTGCAGAT TAAAATTT
GC TCAGTGACCT TTTATCTAAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AAGGGACAAA TGC
TCATGGT ATACTTTTAG GAGATTGTGG CTCTCTATTA ACAGTATTTA TTCAACAAAC ATTTATTGA
G CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TATTATTTCA TTTA
ATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT CAGAAGAAGA AACTGATATT
CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC TAAGATACAG AACCAAGAGT CAAAG
ACATG ATTTTAAACC AAAGCTTTTT CTGCTACTCC ACATTGCTTC CCTAGGTGAG ATCTGAGGCA
TTCCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGCTTAGGAA AAAAAAGGGA AATGTC
CTAA ATAAACAGCT TTCCTATTTA CCAGAAACCA CTAGTTTAAA AATATAATGG GAAAAATCCT A
TTCACTTTA ACAATGTTAA AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAACTTAACA CATTTGT
AGG ATATGTAAAG AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC TTACATGTAT GG
GGAGATAG ACCATCTTAC TGGATTCTAA TATTTAATAG TCTAGGTGTT CCATTTCTCA CCAAATTA
AT GTATACATTT AATACAATGT CAAACGAAAT ATCTTAGGAA TTGCTTACAA ATTGTCAGAT AAT
TACAAAG TTTACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC TCCCCCCAA
A ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAAAATT CTAT
TATAAA GGTGTATTGA TGAAAACAAT TTAATACTAG TGTAGCAATA GGCAGCAAAG CAATGAAACA
GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT TTAAGGTATG ATAAACATGA CATAA
TTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCATTAG AGGGGAGGAA
GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTCATCT TACATTAAAA TAAATTCCAG ATGTAT
TACA TTTAAATTTT TTTAAAAAAA GAAACCACAA AATACTTGAA GAAAATATAA GTTGTTATAT A
GTCTTTTGA TGGGAATTTT TTTTTTTTTC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTG
CAA TGGCATGATC ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AG
CCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTTATTT TTTGTAGA
GA CAGGGGTCTT GCTTTGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTCAAG CACCTCAGCC TCC
CAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATGAA AAGCTTGTA
A AATACTAATT TTTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT TAAAAAGCAA ACAC
AAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC CTTTACAAAA
CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAAAGCAAT TCAAA
ACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAGTTTAAC CTTATCAAAG AAGTAAACTC
TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTTTTCCC ACAAATAACC AAAATCTGTA AGAATA
CTGA GCTGCGAATG TTTCAGAAAA AAAAAAAAAT CATACACCTA GTTCGGCATG TAATTAATAT A
GATCAGAAC ACTTTAAAAA TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCACTT
TGG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG ACCAACATGG TG
AAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA ATCCTGGC
TA CTCGGGAGGC TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG ACA
TTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA TAATAAATA
A AAATAAAATA TTTATATACT CTGACCCATC AATTTGTCCA GCATAATTAG GCATGTGTAC AAGG
GTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA AAAAATTGGG GAAAATGCTT
TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT ATAATCAATA GTATACAGCT ATTAT
TTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACATT CTGTTAGGAT ACGCAAGCAC
CGTGAGGAGA TCAGCTATAA AGTATCAGTG TTTCACACCA CTGCTCCTTT GCTAATAACC TTCAAT
GGCT TTTAAAGAAG TAAAAAACAA AGGCAAAATT CCTTAGTCAG CCCTTAAGAC TCTCTGTTAC T
TAGCTCAAA CTACCCTTTT CAACAACACT GCCCTAACCA GGATGAGTTT TTTGCCCCCC TGGAGTA
CAT TCAGCCTTTC CTTATCAAAC CTTCCTTTAA ATAAGTATCT TCTCCAGGAC CACTTCACTT TC
TTCCCCAA TTTAGCATTT TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC CACTCAAA
CC CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATTT AGGTAAAAAG GTT
TTTACTG TTTATTACCT ACTCAATAAA AATTTTCTTT TTTTGAGACA AGGTCTTACT CTGTCGCCT
A GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCTT CTACCTCCCA GCTCAACAGT CCTC
CCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA CTTTTCATTT
TTTATTTTTT GTGAGATGGA ATCTCACTAT GTTACCCAGG CTGGTCTGCT GATCTCAATT GATCC
TCCCA CTGTGGCCTC CCAAAATGCT GGGATTACAG GCATGAGCCA CAATATCTGG CCCCAGTAAG
CTTTTAAGGC CATTAACATG AGGAACAGTG TTCTTTACAC TATTTTATCA GCTAGGGCTT TGCATG
GAGT AGGAGTTTAG TAAATGCGGT TGATGGGTTA ATCAATGTGT GAAAATATTC AGAGCCACCA A
AAACAGATA TTATGTCTAT TCTCATCAAC AATCAAAATT GAGTAAACAG CCATTTTCTA ATACAGG
AAA CCACAAAACA TTGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA CCAATTTTTT CA
TCCTGATC CAAGTTAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAATTTGA GTAGAAGC
AT TTCTTATGAA GGCTGTCTTG ACTGGATCAC ATTTTTATTG CTGTTGGAGG TGCCAAATGT GTG
TGTTTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT ACCGTCAAG
T GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCTTGCA CTAGGGAAAA GACATATTCC AGGT
ACAAGT ACTCCCACTT TGATGCTACA GAGGAGTTGC TGAACTTTGT GTCATTAATC TCTCTTCGTT
AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT GGGTCTTCAC CAATTTACTA GATCA
TAGTT GGAGAAAATC TACAAAGCCT TGCTCCCTTT AGATTTAAAC AGGTCTCCGT TTAAATTTAG
AATTGCTAAC TTCAAGCGGG CCCTTATGCG ACAGTATGCC TGTCAGTCAT ACTACATTTC CTCAAT
TCCA TTCATGTGAC TGCTCCATAC CCTTCCCTCT CTCTTCATAC TACTATTATC TCTTCCCCCC T
CCCTCATTT TTAACTGATG ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCATCAA AAGAGAG
TTT CCACAAACTC CTACTGCCTT ATCTAGCCCT GTACCATATA CTTTGCATTT CCTCTCATTA CC
ATGGATGT ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTTCCAC TTCAGTTTTG AATATTAT
CA GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC ATTCTCTCTC ATTTTCTTCC ATC
AAGTTTT CCTTTTCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT TTTTCAATG
C TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA CCAG
TTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGGA GAAATAGGAA
CACTTTTACA CTGTTGGTGG GACTGTAAAC TAGTTCAACC ATTGTGGAAG ACAGTGTGGC GATTC
CTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC AGCCATCCCA TTACTGGGTA TATACCCAAA
GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGTTTATTG TGGCACTACT CACAAT
AGCA AAGACTTGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATTAAGAA AATGTGGCAC A
TATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CTTTGTAGGG ACATGGA
GGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TC
TCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA CCCACTGG
GG CCTGTTGTGG GATGAGGGGA GTGGGGAGGG ATAGCATTAG GAGATATACC TAATGTTAAA TGA
TGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG CACGTTGTG
C ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAAACAACTA AAAA
TAAATC TTCTTTTTCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTGTTTTA TGTTGTTCCC
CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC AGTTGTCACC TCAGTTCTCC ACTTC
TTTTT GCTGATAAAC TACTCTAACT AGTTACATAT GATTTCTGTC CCCAGGTCCC CTCCCTCAGT
TGTTTTGAAC ATAATCATTT ATATCATTTA TCATTTTCAC TCTAATTGCA CAACCAAAAA CTCCCT
TTTT TTTTAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA C
TCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTGG GATTATA
CAC ATGCACCACC ACACCTGGCT AATTGCTTTG TTTTTGTTTG TGTGTGTGTG TGTTTTTTTT TT
TTTTTGGA CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCA
AC CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA GGC
ATGCACC ACCATGCCAG GCTAATTTTT TTGTATTTTC AGTAGAGACC AGGTTTCACC ATGTTGGTC
A GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GATT
ACAGAC TTGAGCTACT GCGCCGGGCT ATTTTGTGTT TTTAGTAAAG ACGGGGTTTC ACCATGTTGT
CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCAAAGTGC TGGGA
TTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCCTTTGT TAATATGACT GTTGGCCTGC
ACATTGTCAA ATCCAGTGGC ATTCATCTTA CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTT
TCCT TCTGTTCCTC TATCTGTTTC CAGTATACTG GCCTGGCTTT CTTTTTACCT CTTTTATATG C
TCTTCCAGT CTCAGGCTCC TTTGGGGATT TGAAGGTATG TTGCATTTTG CTATTCAATG AATAATG
ACA AGTAATGATC ACTTAAGACA TTAAGTGGTC AGTTCCTTTA CTAGGATAAA AATAATTTTC TT
CCCAACAT GGGGCATATT CCATTTCCAG TCTGACTGTT CTGTGTAATC TTTGTATTCC TTGGCAGC
CC CTTTTATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATTTGCAC TGGTATAACC AAA
TACAGTT GAACTTTTGG CTTGACTCTT AGCTGAACTC ACCAAAAATA ATTTCTGTAA GAGACTGAG
A CGTCTACGAG TAGGTTTTTC AGAATTAGTA AACATAAATC AAGGATACAC AGGTAGATTT GAAT
TTCAGA TAAACAACAA ATACTTTTTT AGTATGTCTA CTGAAATATT TGTATCTTAT CTGGCAATTC
TACCTGGTAC AGAACTAATC CATTCTCTTG AAAGATCTTG ACTCTGTAAT AAGTTCTTTG GTGAT
GGAAG GGAGGTATTT CTGTAATTAG AGTCACTGTC TTCCTCCCAG TTTTTTATCC TGGCCCAGAT
CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTGCTTTG CAGGAAAAAA AAATTA
AAAA CATCTGAAAA AGCTTTTGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTTT C
TGTCTGCAC TTTACATCAG AACAACCTTG GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGC
TTG GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC AT
GGGTGCAC AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAACGTC ACGGAGAA
AA GGCCAGACTT CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AGTAAAAAAG CAT
GCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC TGCATCATA
T GTTTGTTTCT GTTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGGTTTA ACCCCATAGT CTCC
TGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC TCAAGTTTCC
ACTGATCAGC TTTTCACAAC TCTTATCCTT TCACTAACTT TGGAGCAAGA TTTGAGAATT GGATG
GCTAT TTGAGGGCTA TTTCTGCGCT TTAGTTCAAT GTTTTGTTCT TTCTTTATTA GAGAACTATG
GTTTTTTATT ATATTTACAC TTTAAGTTCT AGGGTACATG TGCACAACGT GCAGATTTGT TACACA
GGTA TAAATGTGCC ATGTTGGTTT GCTGCACCCA TCAACTCGTC ATTTACATTA GGTATTTCTC C
TAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCCC CTTCCTG
TGT CCAAGTGTTC TGTTTATGTG ATAGATTACG TTTATTGATT TGTGTATGTT GAACCAGCCT TG
CATCACAG TCACTTGCTT ACAAGAAACA AACACTTCAC AGATGGATCA TTATGTGTGA TAAGTGAA
AT CCAAGGATTT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TTCCTTCAAC CAT
GAGTGTA TGCAGGTTTT TCTTTTCTTT TTTGAGATGG AGTCTCACTC TTTTACCCAG GCTGGCGCG
C AGTGGTGCGA TCTTGGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA TTCTCCTGCC TCAG
CCTCCC AAGTGGCTGG GATTACAGGC ACCTGCCACT GTCTCCGGCT AATTTTTGTC TTTTTAGTAG
AGATGGGGTT TCACCATCTT GGCCAGCCTT GTCTTGAACT CCTGACCTCA TGAATCATCC TTCTC
AGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT TTTTCAAAGA
CTAAACTTAA AAAAAAAAAA AAAATTTCCC AATGAAATAT AAAACTAAAG TGCTAAACTG TGATAG
ACTG TTTTACAAGA ATGCCAGTTT TCACAAGTGT CTATAGAACA TGTAATTTAG ATAGGTAAGA T
GAAATTTTG ATAATATTTG ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAATTCT AAGCCCC
TCA ACCAACTGAA TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA GT
TTTGGCCA GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA TTCTCTCCTC CCTTTGGA
AT TCAGGCACAA CTGAATGTCA GCATTGACAC TAAAACACAG ATCTTAAGAC TGACAAGCCA GAC
TCTTTGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTTATTTTAT CCCAAAAAAT ATTTCTTTG
A TATATTTTCA AATGGCCCTG CAAAGCTGTC TCTTGTGGGG AAAATTGACA TGCTGTACAG AATT
TCCTTC TCTTTCCAAG TTTTTACTGA TCCAGGAGAG ATTTAACTAA GAGGCTAGCA TGTTTTTTTT
TTTTTTTTTT TGAGGCGGAG TCTTGCTCTG TTGCCCAGGC TGGAGTGCAG TGGCGTGATC TCAGC
TCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATT CTCCTGCCTC AGCTTCCCGA GTAGCTGGGA
TTACAGATCC ATGCCACTAT GCCCAGCTAA TTTTTGTATT TTTTGTAGAG ACAGGGTTTC ACCATG
TTGG CCAGGCTAGT ATTGAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG G
CATTACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTCTGAA GCTACTA
TCT AGAGGCTTCA TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTTATCT TATCCTATTA GT
TTCTACTG ATTCCAGGTC TTTAGATAAT AACAACTCTT TCAACCAATT GCCAATCAGA AAGTCTTT
GA ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTTATC CCGCCTTTCT GGACTGAACC AAT
GTACACC TTATATGTGT TGATGGATAT CTGCCTGTAA CTTCCATTCC CCTAAAATGT ATAACATCA
A GCTGTAACCC AACCACCTTG GGCACATGTT TTCAGGAACT CATGAGACTG TGTTGCAGAC CTTG
GTCACT CATATTTGGC TCACAGTAAA CTTCTTTAAA TATTGTATAG AGTTTGGCTT TTTTCATTGA
CACAGGAAAA ATAAAGAATT GGAAGGTCTT TCATCAGTCA CTGAGCCAGC TTCATATCTG ACTGA
GGTCA TACAGTTCAG TGATTTGTAG CTTTGCTACT TAGATTGCTA TCCATTATCT AGAAGCATCA
GGATCACGTG GGACCTATTG GAAATGCAGA CTTTCCTCCT AGAACCCAGG ACCTTGGAAT ATTCTT
GGCA CATAGTAGGT GCTCAATACA TATTGAACTC CTAGGTGCAA TTCATTAATT CATGAATTAA T
GAATTAACA CGCTCTCAAA GTTTAGTGCT TTTTCACAGA CTAGTCTTTC TGCCTCTTAA GCACTCA
GCT CACCACGCTT CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTGCTTA CATGTGAGTC TG
AGATCAAG TGTTATCTCT TCTGAGAAGT CTTCCCTCAC TGGCCCAAAG GAATTTCTCC TCTATTTT
AG CACTGTCCCA GTTGACTTGT CATTATTCTA GTCTTTTTCA TATTAGTTGT TTTTCATATA TAT
GTTATTA AGGAAACTAG TCATTTCCCC TAATAGAACA AAATTGCTGG CCTTTGGGGT TGGCAATGG
A GGGGAGGCTC TTCTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATTTTTCT TACGAGATTT ATGT
TGCTCA TCTTTAGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC AGAGACCATC TGTTCTCTCA
CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA GTTTTCCTAG CTCTT
TGATC AACTTTCAAA GTTTTACTTC CATTTGAAAA TTTACTAAGT CACCAGGAGA TGGTTTATAC
TGAGAAATAT CCACTCATAC TCTTCCTCTT CAACTTTCTT CCATATACAC CCTATTACAG GGATAT
AGTC TTACTCTATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT C
ACCAGAGGT TCACTTGTGT ATTTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCAT
TTT AACTTTAGAT TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT AATATTTATT TA
TCAAGTGA TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT GTTACAGA
AT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ATTTTTTTGC GACAGGTTCT CGC
TGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTGAACT TCCAGGCTC
A AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCATGTC CAGC
TAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT ATGTTGCCCA AGCTGGTCTT GAACTCCTTG
GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCCACC ATGCC
TGGCC ATAATCAATA CACTTTTAAG AATGCTAGAA TGTTATATCA GATGCATACT TCAGCACTAT
CTCAAGCAAA CTGGGGTGTG GGTTATTCTA CATATAAAGT TCAGCAGTGT TGTTCCACAG TCCCAA
ACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC T
TGCACTCTT GCCAACCCTG TTTCTTGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAG
TCA CTTGTTTAAA AGTTCACAAG TATTGTGTGA ATTGCAGGCA ACCCCTTGAC TCCCTGATTG CC
TGGTCTTC TTCCTTGGGC TCTACCATTT TTTTTCCCCA GCACTCTTTC TGCTGCTCTA AATTTTAA
TT CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CTTCCATCCA ATT
TTGTTTG TCTGTTTGCT TGCTTGCTTG CTTTAATACA TTTCTCTTTT TCTGAGAAGG CTTGAGTCC
A AAACTCTCAG TTACCTGTTG TTCTGTTTCC CGTTAGTTAA TCTCCGAACC TTCATAAATT AAAT
CTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC ACACAGAACA
CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTTT TTATAGGAGA TCCAGGAGAA ATGAA
GTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA CAAGAGTAAA CTTTCTTATA AGTGGTAATT
TTTTTTTACA GGAATAATTG AAAATGGAAA TTACCTTCTC TACTCATAGT AAGTACTCAG TGCGTT
CTTG ATGGGATGAG AATGTGTTTG AGCTTTAGTG TAAGGCAGAA TTCTGTTTAG TCTGCCAGTA T
TGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC AATTCTT
CCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG GGAGAGTTCT CT
GGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCC
TC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TTGGGCTCTG GCC
CCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT GTTACAGTG
C ACTCTTTCAG CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTTC TTCTTGGTAC CCAG
GTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA AGGATGAATG TGGGAGTTTT
ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAG
ATGAT ATTCTCCTGG AGTTTGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC
GACGTTCAGA TGCTCCTCTT CTCTCCTTCT CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCT
CTCT GGAGCCTGGA ATTTGGGGTT TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA A
CTTTTTAGG TGCAAAAAAC AGGAATGCCT CTTCTCACTT AGGGCTATAG ATTTTCAGGC TTGAAGG
TGG GGCCTTTACC AGCGAACCTG TATTTCCCTG TCTCCTGTGC ATATCAATGT AATCAAATAC TG
GGCTGATC CAGGATGTTT CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAGGTT TTTATATT
TG CTTTTGTCAT TTCTTTTTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA GCG
AACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA ATGATTTCAA CTGTAACTAA GGTTATTTC
T CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTGAAGTAT TTCAGAAACA CAAA
GAGGGA GGTTATATAA ATAATATTTT TTTCCTACTT TGGGAAAATG AAAGCTAGTC ACAAAGTTAA
ACGAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG TATTTCCTGT TAAAGAAAAT AAAAT
GCAGA ATATTCAAAA CGTCTGACCA CCCTTCTAAG AAAATGCATC TCTGAGGTAT TTTTCCTTAG
AAGTTATTGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCAGAGTT TAATCT
GTGG AAAGCTTAGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCTCTGAAG ATTTTTAAAA C
GCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATTT GCTGTGC
CAC TGAGCTGACT GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA CACGCATTCT CC
CTTTAAAA AAAATGCCCA CACACTGAAT ACTTTTTTCA TGCAATTTAA AATAAGCGCA CCATCTAG
TT TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GAATTTTGAG CTC
TAGGACA TTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATGAC AGAATAGAA
A TTTCTTTTCC TATTTATCTC TTTGAATAAA ATTTTCAGGA TCTTACAGTG GACAAGTTTG TTATCTACAC ATTGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA GATCTG
AGAG GTGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTTTAC T
GGTGGAGAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG CTACACAGAT ACTGTGT
GGC TAACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG AC
GCACAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG GGACAGATTT CAGCAGCCAT CTGACTTC
AG TGCTCATTTT GATGCTTTCC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAG
GCTCACA CAGGAATACT TGCTTCTGTA GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACA
G ATTCTTTCCT TGGCCAAAAT TTAGTTAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG ACTT
TTTGGT AAAATCCAGT TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA
AGTCACTATC TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTT
AGATT AGAATCCTCC TTACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCTTGAC
CCACCTTGCT CCTCGGCTAT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT CTCCCC
ACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC T
TACCATGCT TTAACAAGTA ACATTGAACC ATTTTTTTCT TTAACAATCT GCTGCACAAT GAGATTA
CTA AAACTTTATT CCATTTTGCC ATGCTGGATG TCCTCAATGG AATGGCTCTT GTGAGCACCA AA
TCATTGTG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT GTAACGTGAT GTATGTTACA TGTGATGT
AT GTTACATAGT TTTTTTTCAT GTTGATCACT TTTTGCCCAT TTTCCTATAT CTTATCAGTT GGA
AGACTGT GGAAGTTTGT AGTACTAAGC CACAAGATGA CTAAGAAGAG TTGAAAGGGC AAGTGGGGC
T AAAAACAGAT TTTGTTTGAC TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAG
GAAGGA GCATCTTTAT CTTTGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTTG
GGGTTTCATG AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCT
TGAAC AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC
TGAGACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTC
TACT TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG AATAGTAAAT A
TGTTTTCTC TTCCTCCTAA TTTTTTAACA CTTTCTTCTC TCTAGCTTAA TTTATTGTTA AGAATAC
AAT CTATAATACA TATGACATAC AAAATATGTC TTAGTTGACT GTTTATGTTA TCTGTAAGGC TT
CAGGTCAA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG GAGTCAAAAG GTGTATGTGG ACTTTCAA
CT GCAGGGGGGT GGGCACCCCT GCCCCCATGT TGTTCAAGGG TCAACTTTAC TGCCAAAGGC AAG
CCTTTAC ATCCACTTTT TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCA
A ATCTTTTTTT TTGCAGATCA CAAATTGGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCA
CTTTCT TTAGTAATAT TTAAGTTAGA TAATATTTAA GTTATAAAGT TGTTCTTTGT AATCGTTAAT
TGTAATTTTT ACATAGTTTC TTTCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGA
TGATG AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT
AGTAGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC TTGGAC
TGCA GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GGTTGCGCTA GTTATGATGG C
AATTTTAAA TGTGTACTTT TACCCAAAGA AAATCCTTAT TATCAACAAT CACAATGCCA TCATAAC
CAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CA
GAGTTTCC TTGCTATTCC TCTTTTTCAA ATGACCATTT AGTAAGCACC TGAAGAAAAT ACTATGGA
CG GCATTGAAAA GTGAAGATAG GTTTAATCTT CTCGAAAATC TAATTCTCCA GATGAAACGC TGA
CACTTAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACATTTGACA CAGAGAAGT
C ATAACTCAGT CAGCACAGAG ACATTTCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTG
GGACAT GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTTTAAA GGCAGAACAT
AGCACATATG TGACTGGGTT TTAGAAGCAA ATTTACAAGA CGCACTCTTC TTCATCCTAA ATAAT
CTGCA ACCAAAGCTT CCAAAAAAGA CAATTTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG
GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTTTCT TCAGGT
TCTG AACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT GAGCAGGACT T
CCTATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA TAATAATTTC CACTTAT
ACA TAGGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT AATCTTCAAG GAACTCTGCT AG
GGATATAA TATTATAAAT CTTGTTTTGC AGATGGAGAA ATTGAATTTT AACCCAAGTT ATCATAAC
CC TTAAATGATT AAATGATACT GTTACATGAG AAAGCTGCGT ATCTGTTTCC TGGATTTGTA GCC
ATAATTT GTGTCTCAAG TCCCTTTTGC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TTGGGCTGT
T TGATACCCCC ACATTTATCT TTTTTTTTTC TCTTTTTTTG TTGAGAGAGT CTTTCCCTGT TGCC
TAGGCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC
TCACGATTCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACC
TAATT TTGTATTTTT AGTAGACAAG GGGTTTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA
CCTCAGGTGA TCTGCCTGCC TTGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCT
GGCC CCAAATTTAT CTTTAATGCC CCAAATTATC TAGTTCCCAT GACTGGGCTT CTGCTTTGAT C
CTTTCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA TTGTGTCCTG AGCCCCTAGT TAGAGGC
TAT GTCTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC ATTAAAAGTC TAATTCTCTT GG
AGAATTGA GAGATACCTA TTTGTCTCAA AATCATTGAA ACCAATTAAT GTATTATGAG CCTCTATC
CA GTGATTTGTA CCTCAATTCC CCAATCCAGC TGTCAAGGCC AATTTGTTCT ACCTTACCTA GTA
GGTAAGT CTGGAATTGT AGCTGTGGCA TTTTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCT
T TTTGGCACCA GGGACCAGTT TTGTGGAAGA CAATTTTTCC ATGAAGGGCT GGGCAGGGGA GTGG
TTTCAG GATGAAACTG TTCCACCTCA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT
AGATCCCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTG
ATCTG ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTTGCCTAC CGCTCACCTC CTGCCGTGCA
GCTCAGTTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGTTGC
TAGG TATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG TATCTGATGA G
ATATAAATT ATTTGATTAT AAATTACTTT CTTCATATTA GAGTTGTGAA TGAGTATCAC ATATAAT
TAT ACATAAACTA GGAATATGCT TTTTAATAAT GTATATAAGT AAGTTTCCTT AACTATGACT TT
CATCTTAG CGTAGTAAGA GGGTGCTAAG AAATATTTGT GATGAAAATA GGCATTGGTA GAGTTGAG
AC CACTGGGTGA TGAAAGAGTG TAAAGATTTT AAAGCCTTCA GATGCTGGTT CAAGGTGAGA AAT
GTGATTG GGAGCAAATC AATTAACTTC TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAA
C ATATGTAAAG CTCTTCTGCC CTGTATACAG TAAATGCTAG TTAGCTATTA TGATCACTAC TAAA
ATGGGG ATGACATAAA CCTCATAAGG TTTTAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA
TATCACATTC AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA GAGAGAAAAA AATGC
TGTCA GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA
TTTTTGCATT TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTATTT AACAACTGGT AAGTCT
ATAC TCCCCCAAAT CTGGAATTCT CCTTTCTTAT TCTTTTTCCT CCTACCAAGA CCGCAGGATC T
TTTACTTGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT TACTTTTATA CTCTGTC
ACA GATTCCCTTT GTTTCCTCAT CTCCATGTGA ATTTAGTTAA ATTCTCAGCA TTCTGATCCT TA
CTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTATTTACA TAAGGCCC
CA ACCTAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTC
ACAGACT TGAGAGAAGA AATGGCAGGA TTTCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAA
A AGGTCAAATA GAATGAAGAT GGAGAATACC GGATTTTCTT ACAAAATGAT TTCCCAGGAG ATCT
CATCAA ATGCACGAGG ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC
TTACAATTTG GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAAC
AGAAA TCAAACACTC AAATTTTTGG TCCTTCTGTT TATTTCATTT TGGATACTCA GTGAATGTTA
ATTAACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA TTTTGA
GTAT TCTGGTCTTA AAAACATCTC TTTCTTCTAC AAACTTCTGA AAGAGATGAA CACCTCCACC T
ACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCATTTTTAC TTAACAGTCT AAGGAAA
GTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT CTGAGGTGAG AATGAGATCA TA
TTTTACAA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC AAAACTCAGA CCACTCACCA GAAAAAAA
TC GGCATTTATA TAGTTGTGTT ACTTTTGGTT TCCTGCATCT TTTCACATCT GGCTCATTTA CAT
CATTTTC TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCA
T ACTGTTATAA TCTTGAAAGT GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAA
CCTGAT CCACAACCAA GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA
GCCAGGAGGT CAAAGGTACA TTCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATC
AGAGT GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG
TTTTCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT CTAACA
TCTT CTTTAAATCT TTAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT GTTTTCCATG T
GGCTCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCA
TTT TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TT
TCTGTCCC TCTCTTCTCC TTTTTGACTT TCTGAGACTG ACAGCTCTTT TGAGGAATCC AGGGTCAA
AG CTCCATCTCT AATGGGTGTT AATTCATTTT CCAGATGGTC TTCTATAGTG AAATTAAACT GAA
AGGTCAT CCTCTTATTA AATGCACACA ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTT
G ATGATACACA CAAATCTGCC TCAATTATTC AATTAGTTTT GTTGGGCCCA ATTTCTCTTT AGCA
GCTTAT ACATGGTAAC AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TTGGTCCTCT
TTCCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGG
CACAT TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG
CTTTTTCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA CCTTAA
GGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA C
CACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTCT
TTC AGCTGTCTTG ATTTGTGTCC AACCATATTC ACCCCCTAAG CTTCCAGAAT AACTTCACTT CT
GTCTTTTA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA GTCAGCGTCC CTTTAAAAAC ATGCATAG
GT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CTTCACTCCA AACATTTAGT CGAGAACAGC AGC
CCTAAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAA
A CGCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTTATT GAGA
ATCTTC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATTTT CACAGTTCTG GCAAGTGGGA
TCTTTGTTCC CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTA
GGAAC GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC
GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA TGTTTA
CAGT GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT CTGAAAAAGC T
CACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAG
AAG CCCGACTTTC TTTCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TC
TATGGTTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTTCCGGT CTGGGCTT
TG GCGGGTCTGG TTTGAAGCTC TCCTGTTTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGC
TAGCGCG GTTCCCCTGG AAGAATTAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTC
C GTCCTGCCCC GACTCCTCAT ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCG
GGTCGC GAACCTTTCT CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCGGCCT
GAACCCCCTC TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAAC
CGTGG TAGATTTAAG TAAGGCTTTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT
TAGCAGTGGA TGTGGCGTTT TCTTCCATTC CTTCTTTCAG TTTTTCTGTA CTCGTTGCTT GCAATT
AAGT GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA T
AGCTCTGGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCTTTT GTCTCCCGTA AAAAGGG
TGG TGAATATGAA TAAGGGCTTT CTTAGCGTTA TAAGAATTAA AGGGCATAGT TCTGTGGTGT GA
AATCTTTA AAAGATGTTC AGTAAATAAA AATGATTTTC CTCCTTCCCC TCTCAGACCT CTTTTTCT
TC TTTCTTTCTT TTTTTTTGAC AAGTTCTCAC TCCTCTCACC CAGGCTGGAG TCTTTCTGAA AGA
GTTCTTC CGCTTGTTGT TGGCTTTCAA CTGTTGGATT TGAGGCGCTT AGCGCCTTCT TCGTCCGGG
T GCAGCACATT CTTGATTGGT CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CTTT
CATGGT AAACCATATG TATATGTATC TTTTTCACAA CATTTGAGCC CAGCTTTATA CAATTACACT
CAAAAGAAAA AAAGTAACCT TCACTTGAGA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAA
GCCCT ATGTAATCAC ATAGAAGTCA TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC
CCCCTTTTTT AGTTTTTGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTT TCAACTTGAA AACAAA
TAGC CACCCTCAAA ACATTCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT T
AGGCTTTGG GAGAACAGAG ACACGGAACG TGATTCCTCT TCTTCCCCAC AAGCTTATAG AGAGACT
TCA TTAAGTTGAA AGTCAACATT CCCACCTAGC TTTGCACTTC AAACGACATA TTCAAAAAAG CC
CAAACTTC CTCTAGTTTT CTTCATCTGA GTAAATGGTT TCACAAACTG AAACCTTGAA TCCTCTCT
GT CTCACACACC CGATCAGTAA GTTCTATTGT TTCTGATTCC AAACTATGTC TTGAATCAAT CCG
TTTATCT CCATCCTCAT TGCTACCACT CTGATTCCAA ACCCTTATCA CCTCTCACTT GGAGTATTA
A TAGTTTCCTT GTTTCTACTC ATAATTCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGAT
CTCGTC ATTTCCCTTT TTAAACCACT TTACCTTCAA GGTTCCAGGT GATCTAAGCC TTGCCCTTCT
CTCATACCTA GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATCT
TTTTG CTCAGCCTGA TTTGTTCTCT CAGCCTTTTG CATATTTCAT GTTTATGTCT TGGCCCAAAT
GTCACTTCCT TAGAGGGGCT TTTTCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA GTCTTA
CACT TGTATCACAT TGGCCTGTTC AGTTTTCTAA AAAGCACATT ACCATTAAAA GAAATGCTCT T
GTTTGCTTT GTATATTTTC CACTTCTACA CATTATGTTG CAAAGTTCAT AAAGGCAGGA TGTTGAT
TTT CTTCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC ACATAGTAAG CATTCATTAA AG
GGCTAAAA ATATTTCATG TTTTAAAAAT ACTTGGGAGT CTAATTAGAC AATACTTTTT TTCAGCTT
AA TGGTAGTATT TTAGCTTCAC TATTTTAACA AATGAAAAAT TTGCAATAAA TCTACAATGC CAT
TACCCCC CAAAATCTTT TTCATGTTTT GCATTTTACG TATTATTTTC CAGGCCTTAC CTGCATGTC
T GCATAATCAT AACTGACTAA TTTTGGAACA GCTGGTAATT ATTTGAGCTT TACTGAAATT TTTT
CATGAG GCCAATTCTA CCCTACTGAA CTCAAATTTG AGTTAATGAT GACCTCATTT TGATTGCTGC
TGTAAAAAAT AAGATTTCGG AAGAGGAATG AATTCTTGTA TTACTGTGGT AGGACTATGG GTTTT
TTTTT GTTTGTTTGT TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT
GCGATCTCAG CTCACAGCAG CCAGGTTCAA GTGATTCTCC TTCCTCAGCC TCCCGAGTAG CTGAGA
TTAC AGGCACGTGC CACCATGCCC GGCTAATTTT TTGTATCTTT AGTAGAGATG GTTTCACCAT G
TTGGCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TGCTGGG
ACT ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TATTCATTTT TCTTATTAAC ATTCTTTGAT GA
TTCTTATG GTGTTGTTAC AGTAAAACAT TTCTAACAAT TATTCTAACA ATTATTCTTG ATGGTGTA
TA TGAAGAATTT ATTGTCGTGT ATTTGTAAGC TGCTATGTGC AGAAGAATTT CAGTCAAATA AAG
TTGGTAA GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAAT
T AAGTACAATA GAAATGTTGA GGAAAGAAAA ATTTCTTGTA ATAGAAATCG GAAGTACAAA CTGG
GCATGG TGGTGTGCAT CTCTAATCCC AGCTCCTTGA GAGGCTGGTA TGGGAGGATC ACTTTAGCCC
AGGAGCTTGA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGAC
CGTCT CTCTTTTTTT TTTTTTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT
TGGCTCACTG CAACCTCTGC CTCCCAGTTT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG CAGCTG
GGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TATTTTGTAT TTTAAGTAGA GACGGGTTCT C
ACCATACTG GCCAGGCTGG TCTTCAACTC CTGACCTCTT GTTCGCCCAT CTAGGTCTCC CAAAGTG
CTG GGATTACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TA
AATAAATA AATCATAAAC CTGTGGATTA TTGTAGCATT GTTTCTCATC TGTCAAAAAT ATTTCATG
AC TATGCATAGT TTGAAAAGGC AAGTTTGTCC CTGGGCAATT TTCAAAATAT TTCTTTAATG TGT
TTTCACA ATACTGTTTA CCTAATAAAT CTTAAGTTTT TAAAAGCAAA ATTAAGCCAG TAATTTGAG
T CCAATTCCAA TCTCTTATGA GTCATTGCTT AAATTTCAAA AGGGTTTTAT TTTTTTTTTA GGTT
TGTTCT GAGTAATGAA TACCCTATTA CTATGATACT AGTATCTTCC TTAATTATCC TACTCATTGT
CTCAACATTC TGACAGTTGG ATTGAGCATA TTCGTAAGTA AAATTGTTTT AACTGTATGA TGTAC
TTTGA TGTTAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGTT CTTACAGTTT TGTATTCCCT
TGAAATGTAA CTGTTCTCTA TGTTACAGCC TTTATAACCT TCAGTTACTT GAAATGAACA AATTCA
TTCA AATTCCAGCA CTTAAAAGTT TTAAATTACA TTTTGGATAA ATACCAAAGT GTTTTGTTGA T
GATGTATGT ATAAACAAAT TGTAAATATT AAACGTTAGT TGTTACGATT AGACCTATAT AAAACAT
GAT ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGTTTA GTGTCATTTA GAAAATGCTT TC
TAAATTGC CAAAAGCTGA TTGTCTAGGT GATAACAAAT TTACCATTTG GAGGAAGTTG ACTTTCTC
AT TTTCATGTCT TCATCAGTCT TACTTGATGA GATTCATTCT TCTAGTCAGA AGAGAGTTTA GAC
TGCTCAG TTTACTCATA TTTTGAGTTA GCTTTTCTAT TTAGAGTTCA CTTGGTTGTG GAATATTCA
T TTATAATTTG AATCTACGTT GTGTAATGGG ACCTAATTTT TTTTTCCTTT GTTTTTGTTG GAGT
CTCGTT TTGTCACCCA GGTTGGAGTG CAGTGGCGTG ATCTTTGCTC ACTGCAACCT CCACCTTCCA
GGTTCAGGTG ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGC
CTGGC TAATTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCATGT TGGCCAGGCT GGTCTCAAAA
CTCCTGAGCT CAAGTGATCC TCCTGCCTTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGC
TGAG CCTGGCCCCA GAGTTTGTTT TGTTTTGTTT TCAAGACAAG ATCTCACTCT ATTGCCCAGG C
TGGAGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTATT CTCCTGC
CTC CATCTTCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT GCTTGGCCTG TGTTTTTGTT TG
TTTGTTTT GGGGGACAGG GTCTTGCTTT GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTA
GC TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGA
GACCGCA GGTGCGTGCT ACCATGCGTG GCTAATTTTC TATTTATATA TTTATTTTTT GGTAGACAT
G AGGTCTTGTC ATGTTTCCCA GGTGGTCTTT AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGC
CACCCA AAGTGTTGGG ATTACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTTTTT AAGTAAATTA
TTTTTTTATC TTGAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAA
CAGAA AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATTTTG ATGAGAACAG TCTCATCTCA
TTTCCGTATA TTCCTGCCAG CCTATCCATC ATTCTTCGTA CATGTTTATC TACATTAAAA TTGGTG
TTAT ATTTTGGAAA CTTTTTGTTT AACTACATTG TGAACATTTT TCATGTTTTA AAATGTCATT T
TAATGATGG CAGATCCTAT TCAATAGATG TACACACACC TATTTAACTG GTCCACAATT GTTGGAT
ATG TAGGTCGTTT CCTTTCTCTC TTTTTTTTTT TTTTTGGCTA CTACTTAATA GTTTCTCTGT AT
AGAATGTG GTATTTTGAA AGTGTATCAA GCTTTAGATT GGTAGTATTC TTGCATTTAA TAAAGGGC
AG TGGCCTTTGT TGACTGACAT GACAATATTT TTATAAAATT TGTTATTTGC TTTACAGAAA TTT
TGAAAAT TATTGTAGAA ATGTTTTTAC CTCATATGAA CCACCTGACA TTGGAACAGA CTTTCTTTT
C ACAAGTGTTA CCAAAGGTAT AATACTATTA CCTGAAAATA CATGTTATAA GGAATCTAGC CTCA
GTCTTA GATGATTTAT TATTAATTAT GGCTCTCTTT TTCTAATATA TCAAATATAT TCAAAATAAA
AATAAGGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATTAGGCAG TTAAA
AACTG TTACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG
GCAGATCATC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACT
AAAA GTACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT G
AGACAGGAG AATTGCTTGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA GATCGTGCCA TTGCACT
CCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACTTAT AT
TTTCAGAT TGTGTGGTTC CTTTACTAAC TGAATTTAAA TTATTTGTAG TCAATTTTAA ATGCTCTT
GT ATTTTAAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAA
AAAAAAA AAGAAAAGCT GGAATATTGG CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGA
A TACATTATTA CATTTTAGAT ATATATGGTA TATGTTTTCT CTGAAAAGCA CAAGCATACC TTTT
TTGTTT TAAATGGAGG GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG TAATTAATCT
CTTATTGAAA TGGGTTTCTA ACTTTAGCTT TGAATCGTAA TCTTTCAAAT TTCTTGTACT CATAG
TCACT TGATGATTCT CTATCTGAAA TATTTCTTAG AATTTGTTCT TGACCACCAG AAAAAGATTC
AACTGTTACA TAGATGAAAA TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT TCTTTA
GCTA CATTGTATTG TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCATTTAA ATTGTTAGAA A
GATCCAAGT ATTAAGATCT AGGGTGGCTA ACTTTTCACA GACAAAAAGC TTGTTTGTAA GGTCATT
TAC TATACCCTTA ATTCAGGAAG GTTAGCTTGA ATTGGGTCAA AAGGAAACTG GTTAGAAAAT AA
GTGAGTAG TGAATAGGCG ATTCAGTGCA AATTCCTTCC AGAAAATACC CTTGTAAATG ACTGTATG
AA TGTGGATTCT TCAAGACAGT CAAATTTATT GTGCGAAAGT AATACTTTTA TTTTTTGCAT CTC
TAAAACA TGAACTTTGA GTGATTTTTT AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAA
A TGGAAAATAA ATTTCTGTTT GGGGCTTTTG GGGGGATTAT GTTGTAAAAA TACCTTTTCT CTGT
ATTTTG TGCTTAATTA GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATGTTAC TAGTGCAAAA
TCAAATTATC GTATTGTGTT TTCTCTGTAA AGTTTTGTCT TGTCTTTTCT AGTGATTTCT CTTAT
TCCTG TTTATTACTT GATTTGTTTT TACAGACTGT GAAATTATTC GATGACATGA TGTATGAATT
AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA ATCCAGACCA CTCTAAGGAA TATTTT
ACAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAATTTTT A
TACTGATAC TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA ATTAAATTTA TAGAATT
AAA GACGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AG
CTAGCTGA CCCTACCTGT ATTTTCAAGG ATATGTGTGG AACACCTGCC ATGTGTTTTG AAGTTTGT
GT TAGTATTCTA AATGGCTAGA CAGTTGTTCC AGTATTTGTA GTTCTGATAG ACTAAAGTTC TGT
GAAAAGA GGAAGAGACT GTGTTTTGTT CATTGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATAC
C TTTTCAGTGC ACAAAAAATA TATTCTAAGT GAAATTTCCT TCCTTATTCA CAGACAATGG TGCA
GCTCTT AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATTTTGGA
AAATATTCAG AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCATTG TAAGG
TGAGT AAAGGTCTAA TTATACTTTG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA
ATGTTTGTAT AAGATTTTAC ATTTTAGTCT ATATTATTGA AATAAACTTT TCCATAGAAT AAAGAA
CATG TAAGTAAATA ATTGTTGCAA AAAAAGTGGT TTTAAGGAAG TCATTAAAAG TGGCTTTTTG G
GGTTTTTTA GTTTTATCTT ATTTCCCCTC TATAAAGAAA GAAGTTTTAA GAATTTGTGT TGAGACA
GAC ACAGGGATCC TGAAATAGTT ATGTCATGTT GCATTGACCA ATATTCAATT ACCATTATGA TT
AGATGTCA GAACTTCCTT TTATAAAGGA AAGTTAATCC TTATTTAGTC CATCTCTACA TGCCAGAG
GT AGCCTTGAGG CACAAAAGCT TGCCTAGAAT TTATGGGTCA CAGACAGTTT TAATATTGCT ATT
TGTTGGG CGAATGAAAA TCACTAGTTA ATTAATACCT CTCTTTGCTG ATAGGATGCT AAAAATGTC
A CGCACCTGGC CTAATGTTAC CCTTTTTTAG TTCTGTATTT GCAAGATCAT GGAAGTCAGA AATA
ATATTT TATACATGCT TGCATCTCTT GAAGCACACT ATATTTAATG GATGTTCACT AAACAATGAA
TGAATATGTG ATTCAGTAAA TTTATGATCT CTAATAGTAT GAATTAAAGT AAATTTGGCT CTTGA
GCTTT GATTTGTTTT TTCTCTCATT TTTATTTATC CGTAATCAGA ATAGTGAATC TGTGTATTCT
GGGTGTTTAC ACCTAGTTTC AGACCTTCTC CAGGCTCTTT TCAAGGAGGC CTATTCTCTT CAAAAG
CAGT TAATGGAACT GCTGGACATG GTTTGCATGG ACCCTTTAGT AGATGACAAT GATGATATTT T
GAATATGGT AATAGGTGAG TGAAGAAAAC TTTCTGCTTA GTATATGGTG ACTATAAATC ATGTATC
AAT TAAAATTGTC TCTAATGATT CATGTTATTT TCTTACTAAT TATGCATTAA AATTGATTTA AA
TCTTACCA AATAAATTTT TAATCTTGAA ATTTGGAATT TGTAAAATTT ATTTTGGGTA CCTTAACC
TA GATTTGCGTA TTTAGTTACT GTAATTTCTC CACAATGATT AACTTATATA ACTTTATAAT CTC
TGAGGTT GTCCATATTC AGAGACAATA ACTTTCACAT TTTTTTAACC ATAACTGATA TTGAGATGC
A GTTTATATTT CCTTCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCT
CATATA CATATTATAA TGAAATAACT CATTTTACAT GTGATGCACT TTATACTAGT TTATTTTTAT
TTTATTTTAT TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATC
TCGGC TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT
GGGATTATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TATTTTTAGT AGAGACAGGG TTTCAC
CGTG TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA GCCTCCCAAA G
TGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGTTTAT TTTTAAAGAA TTGCTGG
TCG TAACACACTT CATTGATTTT ATCACTCATT AATGGATTAT GAACAAGAGT TTGAAAAACA AT
ATAAAGGC AAAGTTTGCA TTCAAAACTT TGGTATAAAG AGAGTAAGTT GGTTTTGTGC AGTGTATC
AG GCACCTGTTG CTCTGCAACA CACCACCTCA AAATCTATTT ATTCACTATT TATTTATTCA TGA
TTCTGTG AGTCTGCAGT TTAGGGTGGG ATGTCCTGAG ACAACTTTCT CTGATCCACC TGGGGCACT
A GCTCACCCAT GTGACTTCAG TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTTG
AGAAAG CCATGTGCAT CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGGTTTCAGG
GTTTCTAAGA GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG CTAGCACTTT TCAAGTTTCT GCTTG
CCTTA ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCATTGTAG
AAAAGTGTGG ATTCACAAAG GGCAGTCATT GTGGCCATTT TTATAAATAA TCTACCACAG ACTGAG
TAAA AGCCTTGCAT GAATACCATG GATATTAATT TGAATTCTTC CTTTTTAGAT TTTCTTTCCT T
AGCAATTTG TTTTGTCATT TTGGATTAGA ATTATATCTG TAGAATATTT CAGTTATAAT AGGGTAC
AAC TTTTATTCCA CTGAACATCT TTAGTTTTAT TTAGGTCATC TGGTAGGTAT AAACTTCAGA AG
TTAATATT CAATATTTAT AAAAACCATT AACAAGTGTG ACACTTAAAT AGTTTAAATA ATTCTTTT
GA CACAACTGTT TCCAAGTTGT GTTACGTATT TTAATTCAAT CAAATGTTGA AATTGTTCAG TAG
ATAGTTT TAATTATAGG AGAAACTCAC CCCCATGACA TTTGGATGTC TTAAAAGTTC TGTTATCTT
T CTTTGCAGTT ATTCATTCTT TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC ATTT
CATGCC AATACTTGGA AGTTTATAAT TAAGTAAGTT TGTTTGTTAT TTTTTACTTT TTAGAAAATG
TTTTCCATAT TCCCCAATCT TAATTATTCA TGATTCTTTA GATTGCATTT AAAACATTTT GTGTG
AATTT AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA
ATTGGACTTC TTTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC TAGTTAGCTA GTACTT
CAGA AATAATGGGC CATGGGCCAG ACTAGAACTT AACCACTTTT CTTCTGCTAC TGTTGTTTAA C
CAGCTATCA AGTATCCTAT TTCTAGGATT AGATAAATTG ATAACTATAA TTAAAACTGA ATATAAT
CTT TTCATTAGGT ACTTTTAAGT TGTTCACACT TAATTCCATT TGTACAGTAA TTTTAACTTT CT
GAAACTGA AGCATTTTAA AGGGTCACCA GGGATAGTGC CTGTAGCATT CATCAGATTC TTAGGGGT
GA GAGGAGATGT GGTTGAGATG TAAAAATGGT TAAGAATATC TACTTTATAC ACATACATAA AAC
ATTAAAG GTCAGTGTAT TTTCAGGTCT TAGGTACTTT TCTTGTACTA CCAGGACATT AAGTTGCCA
T TCAGTGGTTA AGAGTGTTGC CTGGGAGCTG TATCACATGT GCTTAAATCC ATTCTTGAAA TCAT
TTACTC CTTCTGAGCC CTTGGGCTAT TTGGTTAATT TCTCTGAACG TTAGTTTGCT CATCTGAAAA
TGGAAATAAT AATAGCAACT TCTTGACAGG GTTATAGTGA GAATTGAGTT CATCACTGTG AAATG
CTTAG AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT
GATTATCTTC CACTCTTACC CTCTTCCAGT TCATTTTCTG CCCAGCAGAA TGATCTTTTA AAAAGT
AAAT CAGATCATGT TACTCTATTG CTTGAAGTCT ATCCCATTTG ATTAAGAATA ACAACCTAAT C
CTCTGTGGA TGCTGCCTCC TTCACCAGCC TGTCTCATGC TGCTCTCCCT ACTCTTAGTT CCTCAAA
CAT ACCAAACTCT CCTGTCCCAG AGTCTTTTCG TGGTTTTTCC ATCTGCCTAG GATGCTTCTC TC
TCCTATTT TGTGTACCTT GCTAACTCCT GCTTACTGTC TTTCAGTTCT CAGCTTAAGA GTTATATC
TT CATGATAACA TTCTTTGATA TCCTTACCCT AAGATTAAGT TAGATTGATA TCCTTACCCT AAG
AATAAGT TAGATTAGGT CTCTCTATTG TAGCACCTTA GACTCTGTCA TTTGACAAAT CACAGCCCT
A ATTAATTATT CTTAAAATTA TTTAACATTC TCTCTCATGC TAGACCACAA GTTTCATGCA GGTA
AGGCGG AGATTGTGTC CATTTGTTTG ACCCCTTTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT
AGTAAGAATT CAATTAATAT TTTACACAGA GAAAAAATTA GCAACTTATT TAAACAAATA TAACT
GCTTC AGAGGTAAAC TGGGCACATC TTAGTTATAT TATGTGATAT ATGATGCTTT TTGATTGTTT
TTTTAAATGT TCTACAAGGT AGATATTGTT AGAGGTCCTA AGTTACTTGA TGTGTTACTT GTGGTG
ATTG TATTCTTTTC TTTTTATTCA TTTAGGCAGA GCCTTAAGCA CCAGTCCATA ATAAAAAGCC A
GTTGAAACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTTTTC TCCTTCCATT CTTGTTT
ACA GTTAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA TTTGGGCTAA TAGCATTTTA AA
CAGCAACT CTTATTTTCT TTGGCAGTTA GTAAATCTCA TTTGAATGTC TGGGTCAGTC TATTTAAG
AG GATTTTAATT TATTTCATTT GGGTGTTTTT TTTTGATCTG TGGGATTATT TATATCCCAT AAT
TACTTTT CACCCAGAGC ATTGTATTAG ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGC
T CCCTCTTTGC TTGGTAACTG GTTGGTCACA GCATTCTTCT CAGAATCCTT TCATTCTTTT CTGC
ATGAGA ACAAAAATTC TTTTGTTCAT ATTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT
TTTTTCTTCA CCAACGCATT GCGACCTTTA GGGATACAAG TATGTTTGTG CATGTATATG TATGT
ATCAG TCTTTTAAAT TTGATATAGT CATACATTTG TTTTTATTTT GAAAAGTTAG AGTGTTGAAT
TGGTATCCCA TTTATGAAAC ATTATATTCT AAAAATTTGT AGTACGATTA TTGGGAATTA TAACTC
ATTT TCCTGTAACA CTGTTATACA TAGTACCTTT TGCTTTCAGA CTAGCCCTCA ATTTTATTTA A
CTATAGTAG TCCTAAATTA TAAGATTAAT AGTACTCAGG ACCTAACAGT TATATGTCAT TTGTTTT
TTT TTTTTTTGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA GTGCAGTGGT ATGACCTTGG CT
CACTGCAG CCTCTGCCTC ACGGGTTCAA GGGATCGTTC TGCCTTAGCC TCCTGAGTAG CTGGGATT
AT AGGCGCCTGC CACCACGCCT GGCTAATTTT TTTAGTAGAG ACGGGGTTTC GCCATGTTGG CCA
GGCTGGT CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCTTGGCCT CCCAAAGTGC TGGGATTAC
A GGTGTGAGCC ACCGCGCCCA GCCTATATGT AATAATTTTA ATGGGACCAT GAATTGAATA TTTC
TTCCTT GAATAGCAAT GACATAGCCC CTTCTATTGT ACATCTGCAA GCTGATACAG GGAATTCCTT
TGTACCTGCG CTCTTCCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GTCCT
AAAAC TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC
TTTAAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTTA GGAAGGGGCT AACTTT
TTTC TTCTTGCTTC TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TATCCCTTCT TCCTTTTTCC C
TTTCCTTTT TTGTCCTCAC TTCATTCGTG CATCCTTTCT GATTCCTCTT ACCTTGCTAA AAGGAGA
AGT TTGTTTGGGT ATCCTATATC AATGGCAGGA AGGTTGTTTT CTTCTTTACC TTTATCCTAT AG
ATTCATAT TCTCAACACC AACCTCCTCC TTTTTCAGTT TCCTTCTTGC TTCTCTTGAC ACCACAGA
GT TTGCAGCTAG TACTTGGAGA GGAAAATTAA ACAGAGATAC TTGGACCAAG AGTAAGATGA AGA
AAGTCTA AACAACAGTA TAGTCTATAG TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGC
T GTACATAAAG TATATCTTCA GTTTATATAA ACTGCTTATA GATGGAAATC AGAAAATTTA AATT
CTCTTA ACTGTCCAAG AAAATTCTCA TTTTTTCAAA TTTGGGACTG ATAAATGTGA CCAGTTCTGC
TTACTGTCCA TTGCCTGAAA TGGAGCTTTG AGGTGGACTG TATAATTTCT TCAATCTTAA CTCCA
AATTC TGATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATTTAT TTACCAATCA AAGTAAAGTA
TTGAAGTTTT CCTGGCAGTT TTCACTTTGT GTTTTAGTCC ATTTAGGCTG CTATAACAAA ATCCCT
TAAA CTGGGTAAGG GATTATAAAT ATTAGAAATT TATCTCTCAC AGTTCTGGAA GCTGGGAAGC C
CAATATCAA GGCACCAGTA GATTTGGTGT CTAACGAGGG TGTGCCGTCT GCTTCAAAAA TGGCCCC
TTG TTGCTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC CTTCAACCTC TTTTATAAGG GC
ACTTATGT CATTCATGAG GGCAGAGCCC TCATGACTTA ATCACTTCCC CAAAGGCCCC ACCTCTTA
AT AGTATCACAT TGGGTGTTAG GTGTCTGGGA GGACACCAAT CTTCAAGCCA TATCATCTCA CTT
GGAAAAA AGTCAAAATA AAACCAGTAG ATTTAATTAA TATTACACTA TTTATAGAAG CATGTGATG
T ATCATTCCTT GTATTAATTT CCTGGGGTTG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAA
ACAATA GAATTTTATT CTCTCACATT TCTAGAGGCA GAAGTTCACA GTGTGTCAAT AGGGCCATGT
TCTCTGGAAG GCTTTAGGGG AGAATATATT TCATATCTTT CTCTTAGCTT CTCGGTGTCA CTGGC
AATCC TTAGCTTACT TTGGCTTTCT GTGTCTTCAC ATCATCTTTT TATAAGAACA CCAGTGATAG
TGATTAAGGG CATACCTTAC TTTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA CCCTAT
TTCC AAATAAGGCC ACATTCTGAA GTATTGGGAG TTAGAACTTA AAGCTTTTTG GGAGGGACAC A
GTTCAACCC ATAACAACCC CTAAAATCGA TATTTATTCT CAATTAAGTC TTGAAATTGG TTTCAAA
AAG AGAATATTCT ATTAGAGTTT TTAATGTATA GTTTTAACAT ATAGTTCTTT AGCCCCCAAT TT
TTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGA
CT GCGGACTGCA GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCTTCCCGGG TTCACGCCAT TCC
CCTGCCT CAGCCTCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTTTTTG
T ATTTTTAGTA GAGACGGGGT TTCACCTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGA
TCCACC CGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC
CAATTATTTA GTTTTTCTAT AAACAGGGAA ATTTATTTGT GTGGCCCTTA GAACTAATTT AATTT
CCACT CTAATTCCTA CTTATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC
ATATACTATT GTATCTGTTG CCTACACTTA GATTTTATTG CCTGCTATAT TTAAATTTTA TTAGTA
TTTT AATTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACTTTTGAGA GGCCAAGGCA G
AAGGATTGC TTGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACA
AAA AATAAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG TTCTAGTTAC TTGGGAGACT GG
GGTGGGAG GATGCATTGA GCCCAGGAGA TTGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTC
CA GCTTGGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAA
TAGACAG ATTATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAAT
A GATAATAGAC AGATTATCTA AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTA
TCTATC TAAATAGATA ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA
TAGATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAA
GAATG GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTCCTTGC TTATATTACC CACACCTTCT
TTGTTGGCAT TAAGATGCAA ACTTTGTTTT AAACAGTTGA GTAAATCAAA GATGGGACTG TTAAGT
TATT TGTGTTATTT ACCTGCTTTT TGAAAATGTA AAAATAAAAC TCTAGGTTTA ATTAGTAGTA T
GCTATTTAG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA ATTTCCTCTT GAATGAG
AGA GAAAATTTAA AGTAAGCAAA CAAATAAGTT GTGTGTCACC ACTCATTCAG TCATTTAACA AG
TATTTCCA GAGTACTTAT TCTGTGCCAG GAAATGTTGT AGGTGCCCTC AACAACTTAG AGTCTAGC
CT GAGACACAAG TAAGTAGGTA ATTATTATAG AATGGTATGA TCTTTGGAGG ACTGGGTATT GGC
TGGCTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATG
A TGACGTCTAT GCTGATTATA AGGTCAGTGT AGAATAAACT TTGTGCTTTT AAATTTGCAT AGCA
CTGTAT TAGAGAGTTC ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC
CCAGCACTTT GGGAGGCCGA GGTGGGCAGA TTGCTTGAGC TAGGAGTTCG AGACCAGGCT GGCCA
ACATG GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT
AATGCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT GAAGTA
AGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA A
AAAATGATC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG AAAATGGACT ATTTTCA
AAT ATTTTTAATA AGGGTCAAAA TGAGGGATC-3' (フラグメント番号 )(配列番号24
80) 5'-CCTGAGACAG AGGCAGCAGT GATACCCACC TGAGAGATCC TGTGTTTGAA CAACTGCTTC CCA
AAACGGA AAGTATTTCA AGCCTAAACC TTTGGGTGAA AAGAACTCTT GAAGTCATGA TTGCTTCAC
A GTTTCTCTCA GCTCTCACTT TGGTGCTTCT CATTAAAGAG AGTGGAGCCT GGTCTTACAA CACC
TCCACG GAAGCTATGA CTTATGATGA GGCCAGTGCT TATTGTCAGC AAAGGTACAC ACACCTGGTT
GCAATTCAAA ACAAAGAAGA GATTGAGTAC CTAAACTCCA TATTGAGCTA TTCACCAAGT TATTA
CTGGA TTGGAATCAG AAAAGTCAAC AATGTGTGGG TCTGGGTAGG AACCCAGAAA CCTCTGACAG
AAGAAGCCAA GAACTGGGCT CCAGGTGAAC CCAACAATAG GCAAAAAGAT GAGGACTGCG TGGAGA
TCTA CATCAAGAGA GAAAAAGATG TGGGCATGTG GAATGATGAG AGGTGCAGCA AGAAGAAGCT T
GCCCTATGC TACACAGCTG CCTGTACCAA TACATCCTGC AGTGGCCACG GTGAATGTGT AGAGACC
ATC AATAATTACA CTTGCAAGTG TGACCCTGGC TTCAGTGGAC TCAAGTGTGA GCAAATTGTG AA
CTGTACAG CCCTGGAATC CCCTGAGCAT GGAAGCCTGG TTTGCAGTCA CCCACTGGGA AACTTCAG
CT ACAATTCTTC CTGCTCTATC AGCTGTGATA GGGGTTACCT GCCAAGCAGC ATGGAGACCA TGC
AGTGTAT GTCCTCTGGA GAATGGAGTG CTCCTATTCC AGCCTGCAAT GTGGTTGAGT GTGATGCTG
T GACAAATCCA GCCAATGGGT TCGTGGAATG TTTCCAAAAC CCTGGAAGCT TCCCATGGAA CACA
ACCTGT ACATTTGACT GTGAAGAAGG ATTTGAACTA ATGGGAGCCC AGAGCCTTCA GTGTACCTCA
TCTGGGAATT GGGACAACGA GAAGCCAACG TGTAAAGCTG TGACATGCAG GGCCGTCCGC CAGCC
TCAGA ATGGCTCTGT GAGGTGCAGC CATTCCCCTG CTGGAGAGTT CACCTTCAAA TCATCCTGCA
ACTTCACCTG TGAGGAAGGC TTCATGTTGC AGGGACCAGC CCAGGTTGAA TGCACCACTC AAGGGC
AGTG GACACAGCAA ATCCCAGTTT GTGAAGCTTT CCAGTGCACA GCCTTGTCCA ACCCCGAGCG A
GGCTACATG AATTGTCTTC CTAGTGCTTC TGGCAGTTTC CGTTATGGGT CCAGCTGTGA GTTCTCC
TGT GAGCAGGGTT TTGTGTTGAA GGGATCCAAA AGGCTCCAAT GTGGCCCCAC AGGGGAGTGG GA
CAACGAGA AGCCCACATG TGAAGCTGTG AGATGCGATG CTGTCCACCA GCCCCCGAAG GGTTTGGT
GA GGTGTGCTCA TTCCCCTATT GGAGAATTCA CCTACAAGTC CTCTTGTGCC TTCAGCTGTG AGG
AGGGATT TGAATTATAT GGATCAACTC AACTTGAGTG CACATCTCAG GGACAATGGA CAGAAGAGG
T TCCTTCCTGC CAAGTGGTAA AATGTTCAAG CCTGGCAGTT CCGGGAAAGA TCAACATGAG CTGC
AGTGGG GAGCCCGTGT TTGGCACTGT GTGCAAGTTC GCCTGTCCTG AAGGATGGAC GCTCAATGGC
TCTGCAGCTC GGACATGTGG AGCCACAGGA CACTGGTCTG GCCTGCTACC TACCTGTGAA GCTCC
CACTG AGTCCAACAT TCCCTTGGTA GCTGGACTTT CTGCTGCTGG ACTCTCCCTC CTGACATTAG
CACCATTTCT CCTCTGGCTT CGGAAATGCT TACGGAAAGC AAAGAAATTT GTTCCTGCCA GCAGCT
GCCA AAGCCTTGAA TCAGACGGAA GCTACCAAAA GCCTTCTTAC ATCCTTTAAG TTCAAAAGAA T
CAGAAACAG GTGCATCTGG GGAACTAGAG GGATACACTG AAGTTAACAG AGACAGATAA CTCTCCT
CGG GTCTCTGGCC CTTCTTGCCT ACTATGCCAG ATGCCTTTAT GGCTGAAACC GCAACACCCA TC
ACCACTTC AATAGATCAA AGTCCAGCAG GCAAGGACGG CCTTCAACTG AAAAGACTCA GTGTTCCC
TT TCCTACTCTC AGGATCAAGA AAGTGTTGGC TAATGAAGGG AAAGGATATT TTCTTCCAAG CAA
AGGTGAA GAGACCAAGA CTCTGAAATC TCAGAATTCC TTTTCTAACT CTCCCTTGCT CGCTGTAAA
A TCTTGGCACA GAAACACAAT ATTTTGTGGC TTTCTTTCTT TTGCCCTTCA CAGTGTTTCG ACAG
CTGATT ACACAGTTGC TGTCATAAGA ATGAATAATA ATTATCCAGA GTTTAGAGGA AAAAAATGAC
TAAAAATATT ATAACTTAAA AAAATGACAG ATGTTGAATG CCCACAGGCA AATGCATGGA GGGTT
GTTAA TGGTGCAAAT CCTACTGAAT GCTCTGTGCG AGGGTTACTA TGCACAATTT AATCACTTTC
ATCCCTATGG GATTCAGTGC TTCTTAAAGA GTTCTTAAGG ATTGTGATAT TTTTACTTGC ATTGAA
TATA TTATAATCTT CCATACTTCT TCATTCAATA CAAGTGTGGT AGGGACTTAA AAAACTTGTA A
ATGCTGTCA ACTATGATAT GGTAAAAGTT ACTTATTCTA GATTACCCCC TCATTGTTTA TTAACAA
ATT ATGTTACATC TGTTTTAAAT TTATTTCAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GA
TGTTAACC AGAATAAAGT TCTGAGTGTT TTTACTACAG TTGTTTTTTG AAAACATGGT AGAATTGG
AG AGTAAAAACT GAATGGAAGG TTTGTATATT GTCAGATATT TTTTCAGAAA TATGTGGTTT CCA
CGATGAA AAACTTCCAT GAGGCCAAAC GTTTTGAACT AATAAAAGCA TAAATGCAAA CACACAAAG
G TATAATTTTA TGAATGTCTT TGTTGGAAAA GAATACAGAA AGATGGATGT GCTTTGCATT CCTA
CAAAGA TGTTTGTCAG ATGTGATATG TAAACATAAT TCTTGTATAT TATGGAAGAT TTTAAATTCA
CAATAGAAAC TCACCATGTA AAAGAGTCAT CTGGTAGATT TTTAACGAAT GAAGATGTCT AATAG
TTATT CCCTATTTGT TTTCTTCTGT ATGTTAGGGT GCTCTGGAAG AGAGGAATGC CTGTGTGAGC
AAGCATTTAT GTTTATTTAT AAGCAGATTT AACAATTCCA AAGGAATCTC CAGTTTTCAG TTGATC
ACTG GCAATGAAAA ATTCTCAGTC AGTAATTGCC AAAGCTGCTC TAGCCTTGAG GAGTGTGAGA A
TCAAAACTC TCCTACACTT CCATTAACTT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTG
GCT GAACACTGGC AACGACAAAG CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AG
AGGTTCTT TTAAAGGGGC AGAAAAACTC TGGGAAATAA GAGAGAACAA CTACTGTGAT CAGGCTAT
GT ATGGAATACA GTGTTATTTT CTTTGAAATT GTTTAAGTGT TGTAAATATT TATGTAAACT GCA
TTAGAAA TTAGCTGTGT GAAATACCAG TGTGGTTTGT GTTTGAGTTT TATTGAGAAT TTTAAATTA
T AACTTAAAAT ATTTTATAAT TTTTAAAGTA TATATTTATT TAAGCTTATG TCAGACCTAT TTGA
CATAAC ACTATAAAGG TTGACAATAA ATGTGCTTAT GTTT-3'(フラグメント番号 )(配
列番号2479) 5'-CCT TGC CTG CTG G-3' (FRAG. NO: 1739) (配列番号1752) 5'-GTT GTC CC-3' (フラグメント番号1740) (配列番号1753) 5'-GTT CTT GGC TTC TTC TGT C-3' (フラグメント番号1080) (配列番号1088) 5'-GGC TGG TGG-3' (フラグメント番号1083) (配列番号1092) 5'-CGT TGG CTT CTC GTT GTC CC-3' (フラグメント番号1081) (配列番号1089) 5'-TGT GGG CTT CTC GTT GTC CC-3' (フラグメント番号1082) (配列番号1090) 5'-CCC TTC GGG GGC TGG TGG-3' (フラグメント番号1083) (配列番号1091) 5'-GGC CGT CCT TGC CTG CTG G-3' (フラグメント番号1084) (配列番号1093) ヒトPセレクチンフラグメント 5'-TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT TTG CTG TTT TT
T CTC CTT CTT CTC TCC TTT CTT TTC-3' (フラグメント番号1741) (配列番号175
4) 5'-TCC TTT CTT TTC-3' (フラグメント番号1742) (配列番号1755)] 5'-CTC CTT TT-3' (フラグメント番号1743) (配列番号1756) 5'-TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT-3'(フラグメン
ト番号1085)(配列番号1094) 5'-TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT CTT TTC-3' (フラグメント番号1
086) (配列番号1095) ヒト内皮単球(Endothelial Monocyte)活性化因子核酸およびアンチセンスオリ ゴヌクレオチドフラグメント 5'-TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT TTG CTG TTT TT
T CTC CTT CTT CTC TCC TTT CTT TTC-3' (フラグメント番号1744) (配列番号175
7) 5' -CC TTT CTT TTC (フラグメント番号1745) (配列番号1758) 5'-CTG TTC CTC CTT TT-3' (フラグメント番号1746) (配列番号1759) 5'-TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT-3'(フラグメン
ト番号1087)(配列番号1096) 5'-TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT CTT TTC-3' (フラグメント番号1
088) (配列番号1097) ヒトIL3*核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-CTC TGT CTT GTT CTG GTC CTT CGT GGG GCT CTG TGT CGC GTG G GTG CGG CCG
TGG CC GGC GGB CCB GGB GTT GGB GCB GGB GCB GGB CGG GCB GGC GGC TCB TGT
TTG GBT CGG CBG GBG GCB CTC (フラグメント番号1747) (配列番号1760)] 5'-G GBG GCB CTC-3' (FRAG. NO: 1748) (配列番号1761) 5'-GT GGG GCT CTG-3' (フラグメント番号1749) (配列番号1762) HUMIL3AAS1: 5'-CTC TGT CTT GTT CTG GTC CTT CGT GGG GCT CTG-3' (フラグメ
ント番号1089)(配列番号1098) HUMIL3AAS2: 5'-TGT CGC GTG G GTG CGG CCG TGG CC-3' (フラグメント番号1090
) (配列番号1099) GGC GGB CCB GGB GTT GGB GCB GGB GCB GGB CGG GCB GGC GGC TCB TGT TTG GBT
CGG CBG GBG GCB CTC (フラグメント番号1091) (配列番号1100) ヒトIL3レセプター核酸およびアンチセンスオリゴヌクレオチドフラグメント
5'-TCT GGG GTG TCC TGG CCT TCG TGG TTC CTC TTC CTT CGT TTG CCG TCC GCG G
GG GCC CCC GGG CCT GGC TGC GCT CCT GCC CCG CCT CTT TCC CGG GCT CTT GCG C
TG GGG GGT GCT CC CGT GTG TTT GCG CCC TC CTC CTG GTC GCG CTT GTC GTT TTG
GGG CCG GCT TTG CCC GCC TCC CGG CGC CTG GCC CGG CC TTC CTG GGC TGC GTG
CGC GTT CTG TTC TTC TTC CTG GCT CTG GGG TGT CCT GGC CTT CGT GGT TCC TCT
TCC TTC GTT TGC CGT CCG CGG GGG CCC CCG GGC CT GGC TGC GCT CCT GCC CCG C
CT CTT TCC CGG GCT CTT GCG CTG GGG GGT GCT CCC GTG TGT TTG CGC CCT CCT C
CT GGT CGC GCT TGT CGT TTT GG GGC CGG CTT TGC CCG CCT CCC GGC GCC TGG CC
C GGC CTT CCT GGG CTG CGT GCG CGT TCT GTT CTT CTT CCT GGC GCA GGA GAC AG
G GCA GGG CGA TCA GGA GCA GCG TGA GCC AAA GGA GGA CCA TCG GGA ACG CAG CT
C CGG AAC GCA GGA CAG AGG TGC C GC BGG BGB CBG GGC BGG GCG BTC BGG BGC B
GC GTG BGC CBB BGG BGG BCC BTC GGG BBC GCB GCT CCG GBB CGC BGG BCB GBG G
TG CC-3' (フラグメント番号1750) (配列番号1763) GBG GTG CC-3' (フラグメント番号1751) (配列番号1764) 5'- GCC CCG C-3' (フラグメント番号1752) (配列番号1765) 5'-TCTGGGGTGTCCTG (フラグメント番号1092) (配列番号1101) 5'-GCCTTCGTGGTTCC (フラグメント番号1093) (配列番号1102) 5'-TCTTCCTTCGTTTGC (フラグメント番号1094) (配列番号1103) 5'-CGTCCGCGGGGGCCCCCGGGCCT (フラグメント番号1095) (配列番号1105) 5'-GGC TGC GCT CCT GCC CCG C (フラグメント番号1096) (配列番号1104) 5'-CTCTTTCCCGGGCTCTT (フラグメント番号1097) (配列番号1106) 5'-GCGCTGGGGGGTGCTCC (フラグメント番号1098) (配列番号1107) 5'-CGTGTGTTTGCGCCCTCCTCCTGGTCGC (フラグメント番号1099) (配列番号1108) 5'-GCTTGTCGTTTTGG (フラグメント番号1100) (配列番号1109) 5'-GGCCGGCTTTGCCCGCCTCCC (フラグメント番号1101) (配列番号1110) 5'-GGCGCCTGGCCCGGCC (フラグメント番号1102) (配列番号1111) 5'-TTCCTGGGCTGCGTGCGC (フラグメント番号1103) (配列番号1112) 5'-GTTCTGTTCTTCTTCCTGGC (フラグメント番号1104) (配列番号1113) 5'-GCB GGB GBC BGG GCB GGG CGB TCB GGB GCB GCG TGB GCC BBB GGB GGB CCB T
CG GGB BCG CBG CTC CGG BBC GCB GGB 5'-CBG BGG TGC C (フラグメント番号110
5) (配列番号1114) ヒトIL-4核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-CTC TGG TTG GCT TCC TTC GCC GGC BCB TGC TBG CBG GBB GBB CBG BGG GGG B
BG CBG TTG GGB GGT GBG BCC CBT TBB TBG GTG TCG B-3' (フラグメント番号175
3) (配列番号1766) 5'-GCC GGC BCB-3' (フラグメント番号1754) (配列番号1767) 5'-T TCC TTC-3' (フラグメント番号1755) (配列番号1768) 5'-CTC TGG TTG GCT TCC TTC-3' (フラグメント番号1106) (配列番号1115) 5'-GCCGGCBCBTGCTBGCBGGBBGBBCBGBGGGGGBBGCBGTTGGGBGGTGBGBCCCBTTBBTBGGTGTCG
B-3' (フラグメント番号1107) (配列番号1116) ヒトIL4レセプター核酸およびアンチセンスオリゴヌクレオチドフラグメント
5'-TCT GCC CTG TCC GCC GGC TCT TCG GTG GCT CGG CCC CGC TCC TTG TCT TGC C
GC GGG TTG GTT CCT GGG CCT GGT TCT TGC GGG CGT TTC GGT CTG CTG GCT GGT C
TG GGC CCG CGG TGC GGC GGG TGG CTT GCT GTT CTG CCT GGG CTC TCC CCT CTC C
TC CTT TTC TCC CTT CCT CTG TCT TGC CTC CTT CCT CTG GGT CCT CTT GGC CTG G
GC GCT CTT CCC CTC GGG CGG CTG CGG GCG CTC GTG CTG CCT GGT CCG CTC CCT G
GG GGT GCT CCT TCC CTT TCC CCG CTC GTG GGG TTT GCG GGG CTG GGC TGC CCT G
GG GGG TCT GGG CCT TTT GGG GTC GGC TGG CTG CTG CTT CGG GCC GCC TGG GCT T
CC CTG TGC CCC TTT CCT CTG CTG GGT CCC CCT CCC GTT CCA AGC TGC ACC GCA C
AG ACC GGC GCT ACA GGA CAG AGC CAG GCA AGC ACC CAT GGG GAT CCA GGC CCA G
CT GTT CCB BGC TGC BCC GCB CBG BCC GGC GCT BCB GGB CBG BGC CBG GCB BGC B
CC CBT GGG GBT CCB GGC CCB GCT G -3'(フラグメント番号1756)(配列番号1769)
5'-TCTGCGC-3' (フラグメント番号1757) (配列番号1770) 5'-CCT GCT CCT GGG G (フラグメント番号1758) (配列番号1771) 5'-TCTGCGCGCCCCTGCTCC (フラグメント番号1108) (配列番号1117) 5'-CGCCCGGCTTCTCT (フラグメント番号1109) (配列番号1118) 5'-CGTGTGGGCTTCGG (フラグメント番号1110) (配列番号1119) 5'-CCCCGCGCCTCCGTTGTTCTC (フラグメント番号1111) (配列番号1120) 5'-TGCTCGCTGGGCTTG (フラグメント番号1112) (配列番号1121) 5'-GGTTTCCTGGGGCCCTGGGTTTC (フラグメント番号1113) (配列番号1122) 5'-TCTGCCGGGTCGTTTTC (フラグメント番号1114) (配列番号1123) 5'-GGGTGCTGGCTGCG (フラグメント番号1115) (配列番号1124) 5'-CTTGGTGCTGGGGCTCC (フラグメント番号1116) (配列番号1125) 5'-GGCGGCTGCGGGCTGGGTTGGG (フラグメント番号1117) (配列番号1126) 5'-CTTGGCTGGTTCCTGGCCTCGGG (フラグメント番号1118) (配列番号1127) 5'-CCTCCTCCTCCTCCTCGCTCCCTTTTTCTTCCTCT (フラグメント番号1119) (配列番号1
128) 5'-TCCCTGCTGCTCTC (フラグメント番号1120) (配列番号1129) 5'-TGCCCTCCCTTCCCTCCTGG (フラグメント番号1121) (配列番号1130) 5'-GGTGCCTCCTTGGGCCCTGC (フラグメント番号1122) (配列番号1131) 5'-GGCTGCTCCTTGCCCC (フラグメント番号1123) (配列番号1132) 5'-CTCTGGGTCGGGCTGGC (フラグメント番号1124) (配列番号1133) 5'-GGGGCGTCTCTGTGC (フラグメント番号1125) (配列番号1134) 5'-CTGGCCTGGGTGCC (フラグメント番号1126) (配列番号1135) 5'-GCCTCTCCTGGGGGGGTGGCTCCCTGTCC (フラグメント番号1127) (配列番号1136) 5'-CCTTTTCCCCCGGCTCC (フラグメント番号1128) (配列番号1137) 5'-GTGGGGGCTTTGGC (フラグメント番号1129) (配列番号1138) 5'-GGG GGT CTG TGG CCT GCT CCT GGG G (フラグメント番号1130) (配列番号113
9) 5'-AGGGGTCTGGGGCCCTC (フラグメント番号1131) (配列番号1140) 5'-TTTTGGGGGTCTGGCTTG (フラグメント番号1132) (配列番号1141) 5'-GCCTGGCTGCCTTCC (フラグメント番号1133) (配列番号1142) 5'-GGGGCCTGCCGTGGGGC (フラグメント番号1134) (配列番号1143) 5'-TGTCCTCTGTTGCTCCCCTT (フラグメント番号1135) (配列番号1144) 5'-TGCCTGCTGTCTGG (フラグメント番号1136) (配列番号1145) 5'-GGTTCCCGCCTTCCCT (フラグメント番号1137) (配列番号1146) 5'-GTT CCC AGA GCT TGC CAC CTG CAG CAG GAC CAG GCA GCT CAC AGG GAA CAG G
AG CCC AGA GCA AAG CCA CCC CAT TGG GAG ATG CCA AGG CAC CAG GCT G (フラグ
メント番号1138) (配列番号1147) 5'-GTT CCC BGB GCT TGC CBC CTG CBG CBG GBC CBG GCB GCT CBC BGG GBB CBG G
BG CCC BGB GCB BBG CCB CCC CBT TGG GBG BTG CCB BGG CBC CBG GCT G-3' (フ
ラグメント番号1139) (配列番号1148) ヒトIL5*核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-TCCCTGTTTC CCCCCTTTCG TTCTGCGTTT GCCTTTGGCG TTTTTTGTTT GTTTTCTCTC TCC
GTCTTTC TTCTCCCCT GTGGGBBTTT CTGTGGGGBT GGCBTBCBCG TBGGCBGCTC CBBGBGCTBG
CBBBCTCBBB TGCBGBBGCB TCCTCBTGGC TCTGBBBCGG TGGGAATTTC TGTGGGGBTG GCATA
CACGT AGGCAGCTCC AAGAGCTAGC AAACTCAAAT GCAGAAGCATC CTCATGGCTC TGAAACG-3'
(フラグメント番号1759) (配列番号1772) 5'-GCC CCG GG-3' (フラグメント番号1760) (配列番号1773) 5'-G GGT TTC T-3' (フラグメント番号1761) (配列番号1774) 5'-GTG GGG BTG GC-3' (フラグメント番号1762) (配列番号1775) 5'-CCB BGB GCT BGC-3' (フラグメント番号1763) (配列番号1776) 5'-TCC CTG TTT CCC CCC TTT-3' (フラグメント番号1140) (配列番号1149) 5'-CGT TCT GCG TTT GCC TTT GGC-3' (フラグメント番号1141)(配列番号1150) 5'-GTT TTT TGT TTG TTT TCT-3' (フラグメント番号1142)(配列番号1151) 5'-CTC TCC GTC TTT CTT CTC C-3' (フラグメント番号1143) (配列番号1152) 5'-CCT CCT GCC TGT GTC CCT GCT CCC C-3' (フラグメント番号1144) (配列番号
1153) 5'-GAG GGT TTC TGG CTT CCT CTC T-3' (フラグメント番号1145) (配列番号1154
) 5'-TGT CTC TCT GTC CTT TTG TT-3' (フラグメント番号1146) (配列番号1155) 5'-TGT TGT GCG GCC TGG TGC TGC CCT GCC CCG GG-3' (フラグメント番号1147)
(配列番号1156) 5'-GTG GGA ATT TCT GTG GGG BTG GCA TAC ACG TAG GCA GCT CCA AGA GCT AGC A
AA CTC AAA TGC AGA AGC ATC CTC ATG GCT CTG AAA CG-3' (フラグメント番号17
64) (配列番号1777) 5'-GTG GGB BTT TCT GTG GGG BTG GCB TBC BCG TBG GCB GCT CCB BGB GCT BGC B
BB CTC BBB TGC BGB BGC BTC CTC BTG GCT CTG BBB CG-3' (フラグメント番号11
48) (配列番号1157) ヒトIL-5レセプター核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-CTCAGTGGCC CCCAAAAGGA TGAGTAATAC ATGCGCCACG ATGATCATAT CCTTTTTACT ATG
AGGCCGT GTCTGTCGTG TCTTTCCTTT GCTCTTGGTG TGTCTTTGCT GTGCCCTGCC TCTCTGCCC
G TGTCTGTCGT GTCTTTCCTT TGCTCTTGGT GTGTCTTTGC TGTGCCCTGC CTCTCTGCC CGTGT
CTGTC GTGTCTTTCC TTTGCTCTTG GTGTGTCTTT GCTGTGCCCT GCCTCTCTGC-3' (フラグ
メント番号1765) (配列番号1778) 5'-CCG TGT C-3' (フラグメント番号1766) (配列番号1779) 5'-GCCCTGCC-3' (フラグメント番号1767) (配列番号1780) 5'-CCG TGT CTG TCG TGT CT-3' (フラグメント番号1149) (配列番号1158) 5'-TTCCTTTGCTCTTG-3' (フラグメント番号1150) (配列番号1159) 5'-GTGTGTCTTTGCTGT-3' (フラグメント番号1151) (配列番号1160) 5'-GCCCTGCCTCTCTGC-3' (フラグメント番号1152) (配列番号1161) 5'-CT CBGTGGCCCC CBBBBGGBTG BGTBBTBCBT GCGCCBCGBT GBTCBTBTCC TTTTTBCTBT
GBGG (フラグメント番号1768) (配列番号1781) ヒトIL-6レセプターフラグメント 5'-GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCT
CCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGG
C GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGT
CCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC
CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGG
TTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC
GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCC
CTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC T
TGGTTTTGG GCTTTTTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCCG CACGCCTCTT GCCACCT
CCT GCGCAGGGCA GCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGC
GCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGG
C GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGGC
CBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG
GTCCCGCBGB GGCGGBCBGG C-3' (フラグメント番号1769) (配列番号1782) 5'-CCCGGCGC-3' (フラグメント番号1184) (配列番号1193) 5'-GGCCBGCBGG-3' (フラグメント番号1186) (配列番号1195) 5'-GCBGCCBGCBGCG-3' (フラグメント番号1770) (配列番号1783) 5'-C GCBGCCGBCGGCC -3' (フラグメント番号1771) (配列番号1784) 5'-GGGGGTGGCTTCCTGCC3'- (フラグメント番号1153) (配列番号1162) 5'-GCGTCTCTGGGCCGTCCC-3' (フラグメント番号1154) (配列番号1163) 5'-GTCCCTCGGCCCCGCGCCGCGCTCGGCTCCTCTCCC-3' (フラグメント番号1155) (配列
番号1164) 5'-TCTGGCCCGGCTC-3' (フラグメント番号1156) (配列番号1165) 5'-GGGGCGGGGCGGGGCGGTGGGCGGGC-3' (フラグメント番号1157) (配列番号1166) 5'-GGCGCTGCCCTGCGC-3' (フラグメント番号1158) (配列番号1167) 5'-GCGGCGCTGGCCCC-3' (フラグメント番号1159) (配列番号1168) 5'-TGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCT-3' (フラグメント番号1160) (配列番
号1169) 5'-GCTGGCCGCGCCGGG-3' (フラグメント番号1161) (配列番号1170) 5'-GCCTGTCCGCCTCTGCGGG-3' (フラグメント番号1162) (配列番号1171) 5'-CGCTGTCTCCTGGC-3' (フラグメント番号1163) (配列番号1172) 5'-TTGTCTTCCGGCTCT-3' (フラグメント番号1164) (配列番号1173) 5'-TCTGCTGGGGTGGG-3' (フラグメント番号1165) (配列番号1174) 5'-GCTGGGCGGCCGGCCCGGT-3' (フラグメント番号1166) (配列番号1175) 5'-GCTGGGGCTCCTCGGGGGG-3' (フラグメント番号1167) (配列番号1176) 5'-GGGGGCTCTTCCGG-3' (フラグメント番号1168) (配列番号1177) 5'-GCTGTCTCCCTCCGGG-3' (フラグメント番号1169) (配列番号1178) 5'-GCGGGGGTTTCTGGCC-3' (フラグメント番号1170) (配列番号1179) 5'-GTGGGGGTCTTGCC-3' (フラグメント番号1171) (配列番号1180) 5'-TGGCCTCCGGGCTCC-3' (フラグメント番号1172) (配列番号1181) 5'-TGCTTGTCTTGCCTTCCTTC-3' (フラグメント番号1173) (配列番号1182) 5'-TCTGGTCGGTTGTGGCTCG-3' (フラグメント番号1174) (配列番号1183) 5'-GGGCTCCGTGGGTCCCTGGC-3' (フラグメント番号1175) (配列番号1184) 5'-GCCCGTTTGTGTTTTGTC-3' (フラグメント番号1176) (配列番号1185) 5'-TTTTCCCCTGGCGT-3' (フラグメント番号1177) (配列番号1186) 5'-CCCTGTGCCCCTCTCCTCTCCTTCCTCTGCTTCTC-3' (フラグメント番号1178) (配列番
号1187) 5'-GCTCTCCTTTGTGGG-3' (フラグメント番号1179) (配列番号1188) 5'-GCCCTCCCTGCTGCT-3' (フラグメント番号1180) (配列番号1189) 5'-CTTGGTTTTGGGCT-3' (フラグメント番号1181) (配列番号1190) 5'-TTTTTTCTCTTCCTCCTTTTTC-3' (フラグメント番号1182) (配列番号1191) 5'-GTGCGTGGGCCTCC-3' (フラグメント番号1183) (配列番号1192) 5'-GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGG
CCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATG
G TCCCGCAGAG GCGGACAGGC-3' (フラグメント番号1185) (配列番号1194) 5'-GCBCGCCTCT TGCCBCCTCC TGCGCBGGGC BGCGCCTTGG GGCCBGCGCC GCTCCCGGCG CGG
CCBGCBG GGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG
GTCCCGCBGB GGCGGBCBGG C-3' (フラグメント番号1187) (配列番号1196) ヒトIL-6核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'--GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GC
TCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCG
GC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTG
TCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGG
C CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGG
GTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC
GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTC
CCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC
TTGGTTTTGG GCTTTTTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCC GCACGCCTCT TGCCACC
TCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AG
CGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAG
GC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGG
CCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG
GTCCCGCBGB GGCGGBCBGG C-3' (フラグメント番号1772) (配列番号1785) 5'-GGGGCBGG-3' (フラグメント番号1773) (配列番号1786) 5'-GBBGGCBG CBGGC-3' (フラグメント番号1774) (配列番号1787) 5'-CCBGGBGCBG CCCC-3' (フラグメント番号1775) (配列番号1788) 5'-BGGG BGBBGGCBBC-3' (フラグメント番号1776) (配列番号1789) 5'-GCT TCT CTT TCG TTC CCG GTG GGC TCG-3' (フラグメント番号1188) (配列番
号1197) 5'-GTG GCT GTC TGT GTG GGG CGG CT-3' (フラグメント番号1189) (配列番号119
8) 5'-GTG CCT CTT TGC TGC TTT C-3' (フラグメント番号1190) (配列番号1199) 5'-GAT TCT TTG CCT TTT TCT GC-3' (フラグメント番号1191) (配列番号1200) 5'-CTCCTGGGGG TBCTGGGGCB GGGBBGGCBG CBGGCBBCBC CBGGBGCBGC CCCBGGGBGB BGG
CBBCTGG BCCGBBGGCG CTTGTGGBGB BGGBGTTCBT BGCTGGGCTC CTGGBGGGGB GBTBGBGC-
3'(FRAG..NO:1777)(配列番号1790) ヒト単球由来好中球遊走化(Neutrophil Chemotactic)因子核酸およびアンチセ ンスオリゴヌクレオチドフラグメント 5'-GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT TGG
CBBBBCT GCBCCTTCBC BCBGBGCTGC BGBBBTCBGG BBGGCTGCCB BGBGBGCCBC GGCCBGCTT
G GBBGTCBTGT TTBCBCBCBG TGBGBTGGTT CCTTCCGGGC TTGTGTGCTC TGCTGTCTCT TGGT
TCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCTTTC TCTTGG CCCT TGGC-3' (フラグメン
ト番号1778) (配列番号1791) 5'-GGBGT BTG-3' (フラグメント番号1779) (配列番号1792) 5'-GCBCTGBCBT CT-3' (フラグメント番号1780) (配列番号1793) 5'-CCG GTG G-3' (フラグメント番号1781) (配列番号1794) 5'-GG CCC TTG GC-3' (フラグメント番号1782) (配列番号1795) 5'-GCT TGT GTG CTC TGC TGT CTC T-3' (フラグメント番号1192) (配列番号1201
) 5'-TGG TTC CTT CCG GTG GTT TCT TCC TGG CTC TTG TCC T-3' (フラグメント番
号1193) (配列番号1202) 5'-TTC TCT TGG CCC TTG GC-3' (フラグメント番号1194) (配列番号1203) 5'-GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT TGG
CBBBBCT GCBCCTTCBC BCBGBGC-3' (フラグメント番号1783) (配列番号1796) ヒトNeutrophil Elastase (Medullasin) 核酸およびアンチセンスオリゴヌク
レオチドフラグメント 5'-GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC BTT
CGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCC
T CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBB
TCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC BCBGGCGBGG BGBCBCGCGB
GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGCTGG TGGGG
CTGGG GCTCCGGGG TCTCTGCCCC TCCGTGCCGC GTGGGGCCGC GCTCGCCGGC CCCCCCCTGC C
GGGTGGGCT CCCGCCGCGC GCCGGCCTGC CGGCCCCTCG TGGGTCCTGC TGGCCGGGTC CGGGTCC
CGG GGGTGGGGCG CGBGTCGGCG GCCGBGGGTC-3' (フラグメント番号1784) (配列番号
1797) 5'-GG TGG GGC-3' (フラグメント番号1785) (配列番号1798) 5'-G GGG CCG -3' (フラグメント番号1786) (配列番号1799) 5'- GGC CGG GTC CGG G-3' (フラグメント番号1787) (配列番号1800) 5'-TGG TGG GGC TGG GGC TCC GGG GTC TCT GCC CCT CCG TGC-3' (フラグメント
番号1195)(配列番号1204) 5'-CGC GTG GGG CCG CGC TCG CCG GCC CCC C-3' (フラグメント番号1196) (配列
番号1205) 5'-CCT GCC GGG TGG GCT CCC GCC GCG-3' (フラグメント番号1197) (配列番号12
06) 5'-CGC CGG CCT GCC GGC CCC TC-3' (フラグメント番号1198) (配列番号1207) 5'-GTG GGT CCT GCT GGC CGG GTC CGG GTC CCG GGG GTG GGG-3'(フラグメント番
号1199)(配列番号1208) 5'-CGC GBG TCG GCG GCC GBG GGT C-3' (フラグメント番号1200) (配列番号1209
) 5'-GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC BTT
CGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCC
T CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBB
TCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC BCBGGCGBGG BGBCBCGCGB
GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGC-3' (フラ
グメント番号1788) (配列番号1801) ヒト好中球オキシダーゼ(Neutrophil Oxidase)因子核酸およびアンチセンスオ リゴヌクレオチドフラグメント 5'-CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG TCC
GCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG TBGBBBCTB
G GBGGCCGGCC TCCBCCBGGG BCBTGGTCCT TCTTGTCCGC TGCCTCTCTG GGGTTTTCGG TCTG
GGTGGG CTTTCCTCCT GGGGCTGCTG CTGGGCTCTT CTTTTTGTTT CTGGCCTGGT GCTCTCTCGT
GCCCTTTCCC TTGGGTGTCT TGTTTTTGTG GCCTCCBCCB GGGBCBTG-3' (フラグメント番
号1789) (配列番号1802) 5'-CGGGBGTGGG GG-3 ' (フラグメント番号1790) (配列番号1803) 5'-GCCBGCBCCCC-3' (フラグメント番号1791) (配列番号1804) 5'-C CBC CBG-3' (フラグメント番号1792) (配列番号1805) 5'-GGC CTC CBC CBG GGB CBT G-3' (フラグメント番号1201) (配列番号1210) 5'-GTC CTT CTT GTC CGC TGC C -3' (フラグメント番号1202) (配列番号1211) 5'-TCT CTG GGG TTT TCG GTC TGG GTG G-3 (フラグメント番号1203) (配列番号1
212) 5'-GCT TTC CTC CTG GGG CTG CTG CTG-3' (フラグメント番号1204) (配列番号12
13) 5'-GGC TCT TCT TTT TGT TTC TGG CCT GGT G-3' (フラグメント番号1205) (配列
番号1214) 5'-CTC TCT CGT GCC CTT TCC-3' (フラグメント番号1206) (配列番号1215) 5'-CTT GGG TGT CTT GTT TTT GT-3' (フラグメント番号1207) (配列番号1216 5'-GGC CTC CBC CBG GGB CBT G-3' (フラグメント番号1208) (配列番号1217) 5'-CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG TCC
GCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG TBGBBBCTB
G GBGGCC-3' (フラグメント番号1793) (配列番号1806) ヒトカテプシン(Cathepsin)G核酸およびアンチセンスオリゴヌクレオチドフラ グメント 5'-CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG GGB
GTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG GBGBBBGGC
C BGCBGBBGCB GGBGTGGCTG CBTCTTTCCT GGTGGGGCCT GCTCTCCCGG CCTCCGTGTG TTGC
TGGGTG TTTTCCCGTC TCTGGTCTGC CTTCGGGGGT CGT-3' (フラグメント番号1794) (
配列番号1807) 5'-GBBGBTBCGCC-3' (フラグメント番号1795) (配列番号1808) 5'-CBGCCCCBG-3' (フラグメント番号1796) (配列番号1809) 5'-TCC CGT CTC TGG-3' (フラグメント番号1797) (配列番号1810) 5'-GTG GGG CCT GCT CTC CCG GCC TCC G-3' (フラグメント番号1209) (配列番号
1218) 5'-TGT GTT GCT GG GTG TTT TCC CGT CTC TGG-3' (フラグメント番号1210) (配
列番号1219) 5'-TCT GCC TTC GGG GGT CGT-3' (フラグメント番号1211) (配列番号1220) 5'-CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG GGB
GTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG GBGBBBGGC
C BGCBGBBGCB GGBGTGGCTG-3' (フラグメント番号1798) (配列番号1811) ヒトデフェンシン(Defensin)1核酸およびアンチセンスオリゴヌクレオチドフ
ラグメント 5'-CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCB
CCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGC
B GGGTGBCCBG BGBGGGC GGG TCC TCB TGG CTG GGG GCC TGG GCC TGC BGG GCC GCT
CTT GCC TGG BGT GGC TC GCC CBG BGT CTT CCC TGG T GCTCAGCCTC CAAAGGAGCC
AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC AGTCGCCATG AGAACTTCCT ACCTTC
TGCT GTTTACTCTC TGCTTACTTT TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT T
GGCCACAGA TCTGATCATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCG
ATC TTTACCAAAA TTCAAGGCAC CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AG
TGACCAGA AGAAATGACG CAGAAGTGAA ATGAACTTTT TATAAGCATT CTTTTAATAA AGGAAAAT
TG CTTTTGAAGT AT CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC
ACTAGCCACA TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAG
AACA GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA A
ATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTC
AAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GG
GACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATTACTGC AAAAAGTG
GA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT TTC
CAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATTAGTCC
G CTCAGGCTAC CAGATTTATC GTTTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAA
ATTTAT TTCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT
CTCAGGTGTC TGTCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCT
CTGTG TGTGTCTGTC CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA
ATGACCGTGT TTAACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGG
CACT GTTAGGGCTT CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA C
CAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCC
TGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GA
GAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA GAGAGTAACC ATAATTTC
AG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGA
TTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTTGAAGA
G TGGCAGCTGC TTCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAG
AAAACT TGTTTGGAAA AATAACTTGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC
CACTCAGAAC CCCACTGTTC ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTG
AGTAA GCTCTTCAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG
GAAGAGAAGA CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTT
GCAG CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA G
GCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCT
GCC CGATCTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CT
GAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTTTTATAA GCATTCTTTT AATAAAGG
AA AATTGCTTTT GAAGTATACC TCCTTTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGT
AAAGAAG TAGGGGGTTA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTG
G AAAAGGGGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTGTTT GATCCACAAA CCAA
CAGGTG ACTGATTTTG GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT
GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CTTTT
GTCTG AGATGGCCTC AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT
GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG GCACCT
GTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG T
GAAATGAAC TT -3' (フラグメント番号1799) (配列番号3010) 5'-GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGC
CAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CTTTTGTCTG AGATGGCCT
C AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT GCGTCAGCAG TGGA
GGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG GCACCTGTTA CAGAGGGAAG
GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC TT-3'
(フラグメント番号 ) (配列番号2475) 5'-CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA TAG
TGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA GCCACAGGG
A GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA AATGAAGCCT CTAT
TTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTCAAA CTTTGGGAAG
TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GGGACCAGAA ACCAG
GCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATTACTGC AAAAAGTGGA AAAATAGCCT
TTGGATGGAA GTTACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTG
CAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGGCTAC C
AGATTTATC GTTTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCG
CAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TG
TCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTG
TC CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT TTA
ACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTTAGGGCT
T CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAGA CTTG
CAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCATGGAAT
AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA AAATA
AAGTC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA GAGAGTAACC ATAATTTCAG CCCGATGTGA
AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGATTCAAGG CAGAGG
GAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAGCTGC T
TCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTTGG
AAA AATAACTTGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CC
CACTGTTC ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCA
GA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAAGA CTC
TCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG CTACAAGCC
A TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA GGCCTTGGCC ACAG
ATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCTTTAC
CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGA
AGAAA TGACGCAGAA GTGAAATGAA CTTTTTATAA GCATTCTTTT AATAAAGGAA AATTGCTTTT
GAAGTATACC TCCTTTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGG
GTTA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG T
GACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG ACTGATT
TTG-3' (フラグメント番号 ) (配列番号2474) 5'-GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC AGT
CGCCATG AGAACTTCCT ACCTTCTGCT GTTTACTCTC TGCTTACTTT TGTCTGAGAT GGCCTCAGG
T GGTAACTTTC TCACAGGCCT TGGCCACAGA TCTGATCATT ACAATTGCGT CAGCAGTGGA GGGC
AATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC CTGTTACAGA GGGAAGGCCA
AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAACTTTT TATAA
GCATT CTTTTAATAA AGGAAAATTG CTTTTGAAGT AT-3' (フラグメント番号 ) (配
列番号2472) 5'-CCGGGGC-3' (フラグメント番号1800) (配列番号1813) 5'-GG GCCTGCBGGG CC-3' (フラグメント番号1801) (配列番号1814) 5'-GGCBGCB BGG-3' (フラグメント番号1802) (配列番号1815) 5'-GGG TCC TCB TGG CTG GGG-3' (フラグメント番号1212) (配列番号1221) 5'-GCC TGG GCC TGC BGG GCC-3' (フラグメント番号1213) (配列番号1222) 5'-GCT CTT GCC TGG BGT GGC TC-3' (フラグメント番号1214) (配列番号1223) 5'-GCC CBG BGT CTT CCC TGG T-3' (フラグメント番号1215) (配列番号1224) 5'-CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCB
CCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGC
B GGGTGBCCBG BGBGGGC-3' (フラグメント番号1803) (配列番号1816) ヒトデフェンシン(Defensin)2核酸およびアンチセンスオリゴヌクレオチドフ
ラグメント 5'-ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC CAG
CTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGT
C TACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT TACCATCACT TCAA
GTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC
ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG CAGCAAGTGA GAGCT
GCCTC TTACTTTCTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATTTAG
GTAGAGCACA TAAAGGCTTT ATTTCATATT CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAAT
AGTT TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA C
AAAGCCCTG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTA
GCA GTTCTGACAG CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTCTTTTTTT TT
TTTTTCTT TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCT
GG AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTTTTGTA TTTTTCATGG AGATGGGGTT TTG
CCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAAC
T GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTTT ATAAAAATGT CATT
AAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC
AGGTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC ATTGT
CCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT
TTCTCAAACT GCCCTTAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAA
AGGC CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC T
GGGTTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGG
GCT CCTTCATAAG TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CG
GTGCTTCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGC
TC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA ACT
CAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTC
A CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTC
TCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT TCACCAGCTC AGATCTCCTG
TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGG
GTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA
AAGAGCTCTC AATTTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGT
GGGC AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC C
AGCCCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCA
AGA GCAGGAGGAA GGGATTTTCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GT
GCATTGTT CTTTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATG
AG CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTTATAA GGT
GGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTC
T TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGG
AAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG TCTCCTCTCA TTCCCCTCCA
CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG TGTGTCCCCT CCATCCTTTT CTCCT
GCTTC TCTCTCTTCT TCCCTCTCTC TCTTTTTTCT GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT
GTCTTTCTTT CTTTCTCTTT CCTTTCTTCT ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGA
ACAA AGCATTGCTT CCTTCAATAG AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT T
CTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAA
CTG CTGAGACTAT GGTTGAAACC TGTTAGGTGA CTTTTTAAAT AAAAGGCAGA AATTTTGATT TT
ATCTAAAG AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAAC
CT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTC
TGCCTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTC
A CAGGACAGGG TACAGCCCAT TGAAACCTAC TTTTAAACCT GGATGCCTAA CCTTCATTTT CTCC
TTGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG
GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTG
TGAAA TCCTCATTTT ACCAATCTTA TTTATGAGTC CTGGGTTTTG TGAGAACAAT GGGGTTCTGA
GAGGCACCAG AGACCTCATG TTTTCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAG
GGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG G
GAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATAT
TAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TG
GTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTATCC CATCTCAGGT CAAATACT
TA ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTTA AAATGGAGGT ATG
GTGGCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA GCTCCTACC
A GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA ATCAGGTTCT ACAA
AAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC CAAATGACTG
ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA GAAAGAAGCC CGCTGCGGAT TTACT
CAAGG CGATACTGAC ACAGGGTTTG TGTTTTTCCA ACATGAGTTT TGAGTTCTTA CACGCTGTTT
GCTCTTTTTG TGTGTTTTTT CCCTGTTAGG TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCT
TAAG AGTGGAGCCA TATGTCATCC AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT G
GTCTCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGG
ATT CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AA
AGATACGC AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCT
AA TATCCTTGAA ACACCTTTTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGG
AGTGCTT TCCAGGGTCA CAGGCATCTG TATTCTTTGG ATTCCTTGAC CTTCCCCATT TATTCCCGG
C ATTTTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC CCTCACCTAC CCCA
CATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC ATGGAATCAT AGTGGATCTG
CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCTTCTTC TGGCTAAGGT TTCTT
ATGCA ATTAT GAATTCACAT TTCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCT
CTATC AAATTTTCAT GCCTTCAATA ATTTCTAATT CATCAGTCAG TGTTTTTCCA TCCTTTACTG
TGATGATGCC CTTTCTTCCA AACTTTTTCA TTGCATCAGA GATGATGTTA CCAATTTCTT TGTCTC
CATT TGCAGAAATT GTAGCAACCT GTGCAATTTC TTCAGGTTTG GTCACAGGTT TAGACTGCTT T
TTAAGTTCA GCAATTACAG CATCAACAGC TAACATCACA CCTCTCTTGA TTTCCACTGG ATTAGCA
CCT TTGCTAACCT TCTGGAAGGC TTATTTGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GT
GCCATCCC CCAGTCTCTC CATTTGTGTT ATTGGCAACA TCTTGGACAA GTTTAGCTCC AATGCTTT
TA TATTTATCCT TTAAGTCAAT TGACTTTGCA TCAGTCACAC CATCTTTTGT TACTTTGGGA CTT
CCCCAGC TATGTTCAAT AATTACTGTT CTTCCCTTTG GCCCCATTGT AATGGCTACA GCATCGACA
A AAAGTCTACA CTTTGAAGCA TTAAGGCTCA GACATCAGCA CCAAATTTTA CATCTTTACC ATCA
CTTCAA GTGAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT
GGAAGCATTT CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTG
AGAGC TGCCTCTTAC TTTCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTT
AGGCAGAGCA CATAAAGGCT TTATTTCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG GAAGAA
ATAG TTTTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG CACACAAGGA A
ACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC TGGATGCATA TTTGTTT
AGC AGTTCTGACA GCATCTGACC CAGCCCTCTC TTTGCATACC CCACCAGAAC CTTCTTTTTT TT
TTTTTTTC TTTGAGACTG AGTCTTGCTC TGTCGGAAGC GATTCCCGTG CCTCAGCCTC CCAAATAC
CT GGAATTATAG GCGTAAGCCA TCATGCCTGG CTAATTTTTG TATTTTTCAT GGAGATGGGG TTT
TGCCATG TTGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAA
A GTGCTGGGAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT GTCA
TTAAGG ATCTTGGCTG CACAATATCG TTACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA
TCAGGGTTCT TCAGAACCTG ACATTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCAT
TGTCC CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT
TGTTTCTCAA ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT TCCCAA
GAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG CCAATTGCTA C
TCTGGGTTA CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA CACAGCCCTG AAAACAT
GGG GCTCCTTCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TTGCAGCCCT AC
TCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCT
GG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG ACATTCCCTG AGTGACGGTG TGAATGGAAG GAA
CTCAAGT GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAG
T CACAATCCCA TCCTCCCATT CTCCTTCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTC
TCTCCC GTGGGGAAGA TGGGGAGTTT CAGGGGAACT TTCACATAAA TTTCACCAGC TCAGATCTCC
TGTGAGGATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTG
GGTTT GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG
AAAGAGCTCT CAATTTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAG
TGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTTTGAGTT TGTTCTCACG TGAGACAGAC C
CAGCCCCTC ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG AGGAATTTTC TGGTCCC
AAG AGCAGGAGGA AGGGATTTTC TGGGGTTTCC TGAGTCCAGA TTTGCATAAG ATCTCCTGAG TG
TGCATTGT TCTTTGAGGA CCATTCTCTG ACTCACCAGG TAAGTGGCTG AATTCTAACC TCTGTAAT
GA GCATTGCACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GACCTTTATA AGG
TGGAAGG CTTGATGTCC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGT
C TTGTATCTCC TCTTCTCGTT CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGG
GAAATA GGAGGGTTGG CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC
ACCTATCTCT CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTTT TCTCC
TGCTT CTCTCTCTTC TTCCCTCTCT CTCTTTTTTT CTGTCTTTCT TTTTCCTCTC TCCCTAGAGC
ATGTCTTTCT TTCTTTCTCT TTCCTTTCTT CTACCCACAC TTTTAGACTG AGTAGACTGA ATGCCC
TATT TAATTGAACC AAGCATTGCT TCCTTCAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC T
CACTCGTTC TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT CATCTCTTCA CTGCTTT
CCA TGCTACAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG ACTTTTTAAA TAAAAGGCAG AA
ATTTTGAT TTTATCTAAA GAAAGTAGTA TAGAATGTCA TTTTCTAAAT TTTTATATTT AAAGAGTA
GA TACTGCAACC TAGAGAATTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCA
GCAGACA CTCTGCCCCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCA
C TGCAGGTTCA CAGGACAGGG ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTC
ATTTTC TCCTTGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG
GGAAGGATGG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGAT
ATCAT CTTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG
GGGTTCTGAG AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAG
GGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA A
TGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATT
GTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CT
TTTTTATC CCATCTCAGA TCAAATACTT AACAGACTAA ATGATTTGAA AAAGCAAAAG TTTACTGG
CT TGTGTGTGTT AAAATGGAGG TATGGTGGCT TTGATATTAT CTTCTTGTGG TGGAGCTGAA TTC
ACAAGAG ATCGTTGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCA
G GGTCTTTCAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCA
TGTCAG AAACTTAGAT CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG
AGAAAGAAGC CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTGTTTTTCC AACAT
GAGTT TTGAGTTCTT ACACGCTGTT TGCTCTTTTT GTGTGTTTTT TCCCTGTTAG GTGTTTTTGG
TGGTATAGGC GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTCTTTTG CCCTAG
AAGG TATAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA G
GCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGT
AAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT CCTAGTAATT GTGGTCATTG GG
TGATGTTG GTTTGGGCAG GCCATCTCTA ATATCCTTGA AACACCTTTT TCTGCTCTCC AGGAAGGG
GT CAGGGCTGCC ACAGCGGGGC TTGGAGTGC-3' (フラグメント番号 ) (配列番号30
11) 5'-GAATTCACAT TTCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCTCTATC AAA
TTTTCAT GCCTTCAATA ATTTCTAATT CATCAGTCAG TGTTTTTCCA TCCTTTACTG TGATGATGC
C CTTTCTTCCA AACTTTTTCA TTGCATCAGA GATGATGTTA CCAATTTCTT TGTCTCCATT TGCA
GAAATT GTAGCAACCT GTGCAATTTC TTCAGGTTTG GTCACAGGTT TAGACTGCTT TTTAAGTTCA
GCAATTACAG CATCAACAGC TAACATCACA CCTCTCTTGA TTTCCACTGG ATTAGCACCT TTGCT
AACCT TCTGGAAGGC TTATTTGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GTGCCATCCC
CCAGTCTCTC CATTTGTGTT ATTGGCAACA TCTTGGACAA GTTTAGCTCC AATGCTTTTA TATTTA
TCCT TTAAGTCAAT TGACTTTGCA TCAGTCACAC CATCTTTTGT TACTTTGGGA CTTCCCCAGC T
ATGTTCAAT AATTACTGTT CTTCCCTTTG GCCCCATTGT AATGGCTACA GCATCGACAA AAAGTCT
ACA CTTTGAAGCA TTAAGGCTCA GACATCAGCA CCAAATTTTA CATCTTTACC ATCACTTCAA GT
GAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCAT
TT CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC TGC
CTCTTAC TTTCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTT AGGCAGAGC
A CATAAAGGCT TTATTTCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG GAAGAAATAG TTTT
AGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG CACACAAGGA AACAAAGCCC
TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC TGGATGCATA TTTGTTTAGC AGTTC
TGACA GCATCTGACC CAGCCCTCTC TTTGCATACC CCACCAGAAC CTTCTTTTTT TTTTTTTTTC
TTTGAGACTG AGTCTTGCTC TGTCGGAAGC GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAATT
ATAG GCGTAAGCCA TCATGCCTGG CTAATTTTTG TATTTTTCAT GGAGATGGGG TTTTGCCATG T
TGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGG
GAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT GTCATTAAGG AT
CTTGGCTG CACAATATCG TTACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTT
CT TCAGAACCTG ACATTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC CCA
TGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TGTTTCTCA
A ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT TCCCAAGAAA GGCC
CTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG CCAATTGCTA CTCTGGGTTA
CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA CACAGCCCTG AAAACATGGG GCTCC
TTCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT
TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCA
AAGC CCTGAAGTCC TGTGGAGCTG ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT G
CGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATC
CCA TCCTCCCATT CTCCTTCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GT
GGGGAAGA TGGGGAGTTT CAGGGGAACT TTCACATAAA TTTCACCAGC TCAGATCTCC TGTGAGGA
TG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGTTT GAG
CCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG AAAGAGCTC
T CAATTTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG CAGC
AGGTGA GTGGCAGGTT ATAGGTCCTG AGTTTGAGTT TGTTCTCACG TGAGACAGAC CCAGCCCCTC
ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG AGGAATTTTC TGGTCCCAAG AGCAG
GAGGA AGGGATTTTC TGGGGTTTCC TGAGTCCAGA TTTGCATAAG ATCTCCTGAG TGTGCATTGT
TCTTTGAGGA CCATTCTCTG ACTCACCAGG TAAGTGGCTG AATTCTAACC TCTGTAATGA GCATTG
CACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GACCTTTATA AGGTGGAAGG C
TTGATGTCC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATC
TCC TCTTCTCGTT CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGGGAAATA GG
AGGGTTGG CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTATCT
CT CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTTT TCTCCTGCTT CTC
TCTCTTC TTCCCTCTCT CTCTTTTTTT CTGTCTTTCT TTTTCCTCTC TCCCTAGAGC ATGTCTTTC
T TTCTTTCTCT TTCCTTTCTT CTACCCACAC TTTTAGACTG AGTAGACTGA ATGCCCTATT TAAT
TGAACC AAGCATTGCT TCCTTCAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC TCACTCGTTC
TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT CATCTCTTCA CTGCTTTCCA TGCTA
CAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG ACTTTTTAAA TAAAAGGCAG AAATTTTGAT
TTTATCTAAA GAAAGTAGTA TAGAATGTCA TTTTCTAAAT TTTTATATTT AAAGAGTAGA TACTGC
AACC TAGAGAATTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA C
TCTGCCCCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGT
TCA CAGGACAGGG ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTCATTTTC TC
CTTGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGAT
GG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT CTT
GTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG GGGTTCTGA
G AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAG
GGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTTGA
AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTT
CAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTTATC
CCATCTCAGA TCAAATACTT AACAGACTAA ATGATTTGAA AAAGCAAAAG TTTACTGGCT TGTGTG
TGTT AAAATGGAGG TATGGTGGCT TTGATATTAT CTTCTTGTGG TGGAGCTGAA TTCACAAGAG A
TCGTTGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCTTT
CAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCATGTCAG AA
ACTTAGAT CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG AGAAAGAA
GC CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTGTTTTTCC AACATGAGTT TTG
AGTTCTT ACACGCTGTT TGCTCTTTTT GTGTGTTTTT TCCCTGTTAG GTGTTTTTGG TGGTATAGG
C GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTCTTTTG CCCTAGAAGG TATA
AACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA GGCCAAGAAG
CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGTAAA CCAAA
TTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT CCTAGTAATT GTGGTCATTG GGTGATGTTG
GTTTGGGCAG GCCATCTCTA ATATCCTTGA AACACCTTTT TCTGCTCTCC AGGAAGGGGT CAGGGC
TGCC ACAGCGGGGC TTGGAGTGC-3' (フラグメント番号 ) (配列番号2476) 5'-ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC CAG
CTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGT
C TACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT TACCATCACT TCAA
GTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC
ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG CAGCAAGTGA GAGCT
GCCTC TTACTTTCTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATTTAG
GTAGAGCACA TAAAGGCTTT ATTTCATATT CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAAT
AGTT TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA C
AAAGCCCTG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTA
GCA GTTCTGACAG CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTCTTTTTTT TT
TTTTTCTT TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCT
GG AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTTTTGTA TTTTTCATGG AGATGGGGTT TTG
CCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAAC
T GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTTT ATAAAAATGT CATT
AAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC
AGGTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC ATTGT
CCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT
TTCTCAAACT GCCCTTAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAA
AGGC CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC T
GGGTTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGG
GCT CCTTCATAAG TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CG
GTGCTTCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGC
TC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA ACT
CAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTC
A CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTC
TCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT TCACCAGCTC AGATCTCCTG
TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGG
GTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA
AAGAGCTCTC AATTTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGT
GGGC AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC C
AGCCCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCA
AGA GCAGGAGGAA GGGATTTTCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GT
GCATTGTT CTTTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATG
AG CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTTATAA GGT
GGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTC
T TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGG
AAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG TCTCCTCTCA TTCCCCTCCA
CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG TGTGTCCCCT CCATCCTTTT CTCCT
GCTTC TCTCTCTTCT TCCCTCTCTC TCTTTTTTCT GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT
GTCTTTCTTT CTTTCTCTTT CCTTTCTTCT ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGA
ACAA AGCATTGCTT CCTTCAATAG AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT T
CTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAA
CTG CTGAGACTAT GGTTGAAACC TGTTAGGTGA CTTTTTAAAT AAAAGGCAGA AATTTTGATT TT
ATCTAAAG AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAAC
CT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTC
TGCCTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTC
A CAGGACAGGG TACAGCCCAT TGAAACCTAC TTTTAAACCT GGATGCCTAA CCTTCATTTT CTCC
TTGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG
GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTG
TGAAA TCCTCATTTT ACCAATCTTA TTTATGAGTC CTGGGTTTTG TGAGAACAAT GGGGTTCTGA
GAGGCACCAG AGACCTCATG TTTTCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAG
GGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG G
GAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATAT
TAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TG
GTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTATCC CATCTCAGGT CAAATACT
TA ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTTA AAATGGAGGT ATG
GTGGCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA GCTCCTACC
A GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA ATCAGGTTCT ACAA
AAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC CAAATGACTG
ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA GAAAGAAGCC CGCTGCGGAT TTACT
CAAGG CGATACTGAC ACAGGGTTTG TGTTTTTCCA ACATGAGTTT TGAGTTCTTA CACGCTGTTT
GCTCTTTTTG TGTGTTTTTT CCCTGTTAGG TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCT
TAAG AGTGGAGCCA TATGTCATCC AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT G
GTCTCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGG
ATT CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AA
AGATACGC AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCT
AA TATCCTTGAA ACACCTTTTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGG
AGTGCTT TCCAGGGTCA CAGGCATCTG TATTCTTTGG ATTCCTTGAC CTTCCCCATT TATTCCCGG
C ATTTTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC CCTCACCTAC CCCA
CATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC ATGGAATCAT AGTGGATCTG
CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCTTCTTC TGGCTAAGGT TTCTT
ATGCA ATTAT GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGT
GTCCA AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CTTAAACACC
AGCAGCCCTC ACAACCACAG ATCGTGTTTT AAGGATGAGG AGGTAGTTCT CTGGATGCAC AGGCTT
CAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA GTTGGAGCAT T
GCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GTTCTCCGAT GTGTACC
AGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGCTTTTGC TGAATGCTTC TC
TGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATGCCCAGAC TCCCACCT
CC TTTCTTGGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATGC CTCAGACCAG TTC
TTGGCCC AGATGATCCT AGACAATTGT TTAAGCTTAA ACTGTTCATT GGCCAAGCAA ACAGGTGAT
A GTACCTCTGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGT
TCCACA TAGCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC
AGCCAAATGG CTTTCATTAG TTTTTATGGT TAGACCCCAG GTCCTCGGGA CACTGCTTTA GAAAC
ACATT CCAAATCCTC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTCTTTGCA GGGCGTATAC
TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTTAAATATT CCCTTGGTGC AGGTAGTTCA GCTTAG
CCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCCATA GTTGGTTGCT G
CCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AGTTCTACTT TAACCTC
ACC TTCCCACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA TTTAATGGAC CCAACAGAAA GT
AACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCTT TAAATAGGGG AAGTCCACTT GTGCACGG
CT GCTCCTTGCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCT
AGCTAGA GGATCTGTAA GTACTACAAA ACTTAAACTT TACACTGAGT TTTCATCATT GAAGCTATG
C CTCCAATCTG ACCTCTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGG
AACGTC TGTCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAACTTAA TAGAGAAACT
CAAGCAGTTT CCTTCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTAT
CACAG GTCTTTGGAA CATTCTTTTG AGAGAAACCT ATTTAGGTCC TTGGTCTGTT TTTCAATCAG
GTTGTTTGAT TTTTGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT ATTTGCCCCT TCTGCC
ATGT AGGTTTTGCA AATATTTTCT CTCATTTTCT GGGTTATCTT TTCACTCGGT TGATTGTTTC C
TTTGCTGTG CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTATTT TCCCTTTTAT TGCCTGT
GCC TTTGGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAGCTTT ATCCTTCTAT AC
ACTTCTAG TAGTTTATGG TTTCAGTTGT TACATTTAGG TTTTCAATTC ATTCTGAGTT GATGTTCC
TA CATGGTGTGA GATAAAGATT TAAATACATA CATATATAAA ATCATGAGGT AGTGTACACT ATA
AATATAC AATTGTTAAT TGTTACTCAA GTCTAAGTAG AGGTGGAAAT AATAAACTTT CTTTTTTTT
A CTTAAACCAC TCTGTGTCAC TGAGCTGATT TCACCTTTAG CCTGATAAAA TCATTGTCCT CTCC
ACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT
CACCTGAATC CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAG
ACCTC CAGAGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT TTGTTCCCTG AGCCTGTTGA
ATCAAAGTGC AATTTCTATT CTTTTTGGAA TGTTAAAAAG TGAATCATAA TATTTAAGCA GGTGAA
CCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC AGACATTAAA G
GTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCTTGAGAC CAATGGG
CCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGTTTCTTG TCTCCGAGCC TT
CTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTC
CT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCA
GGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGC
G GACATCCCAG AAGTGGTTGT TTCCCTTGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTG
AGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG
TCTCAGCAGT CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTA
GAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTTATTTCTC CAAAGACTTG ATTCCAAGAA
ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT AAACAA
GTAG ACTTAGTTGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTTTTAAA AACTGCAGCC A
AGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAA
TGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA TTCCTATCGA CTGAGGTTGT TC
GTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTCTTT
TT CTTACCCACT GCTAACTCCA TACTCAATTT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAA
ACATGGA CTGCTATTGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCT
A CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTT
GCTTTG AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTT TCCTCATCTC
AAATAAATGC CTTGTTACAA GATTTCTGTG TTTCCACCTC TTTAATGTGT GATATGTGTC TGTGT
CAAGA CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAATTTTT GAACAATATA-3' (フラグ
メント番号 ) (配列番号3012) ヒトデフェンシン(Defensin)3核酸およびアンチセンスオリゴヌクレオチドフ
ラグメント 5'-CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG
GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT G
GBGGBGGGB GBGCBGGGGG TCCTCBTGGC TGGGGTCCCT CTCTCCCGTC CT CCTACCTTGC TATA
GAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG
ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGC
TGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC
CAGAAGTGGT TGTTTCCCTT GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAA
ACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT C
TACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATTT
GCT TTGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAATTTC CTTT-3' (フラ
グメント番号1804) (配列番号3013) 5'-CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCC
TAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC TCCTGGTGG
C CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAG
ATTGCA GCGGACATCC CAGAAGTGGT TGTTTCCCTT GCATGGGACG AAAGCTTGGC TCCAAAGCAT
CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCG
CTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGAA
AAATGAGCTC AAAATTTGCT TTGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAA
TTTC CTTT-3' (フラグメント番号 ) (配列番号2478) 5'-GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA AGG
CGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CTTAAACACC AGCAGCCCT
C ACAACCACAG ATCGTGTTTT AAGGATGAGG AGGTAGTTCT CTGGATGCAC AGGCTTCAAT CCAA
ATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA GTTGGAGCAT TGCATTCACA
GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GTTCTCCGAT GTGTACCAGT GAAGG
ATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGCTTTTGC TGAATGCTTC TCTGAAGGCC
CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATGCCCAGAC TCCCACCTCC TTTCTT
GGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATGC CTCAGACCAG TTCTTGGCCC A
GATGATCCT AGACAATTGT TTAAGCTTAA ACTGTTCATT GGCCAAGCAA ACAGGTGATA GTACCTC
TGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGTTCCACA TA
GCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC AGCCAAAT
GG CTTTCATTAG TTTTTATGGT TAGACCCCAG GTCCTCGGGA CACTGCTTTA GAAACACATT CCA
AATCCTC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTCTTTGCA GGGCGTATAC TGTGATACG
C AGCCAGGCTG TCCCAGAGGC CTTAAATATT CCCTTGGTGC AGGTAGTTCA GCTTAGCCAC AGCC
AATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCCATA GTTGGTTGCT GCCTGGGCCT
GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AGTTCTACTT TAACCTCACC TTCCC
ACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA TTTAATGGAC CCAACAGAAA GTAACCCCGG
AAATTAGGAC ACCTCATCCC AAAAGACCTT TAAATAGGGG AAGTCCACTT GTGCACGGCT GCTCCT
TGCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA G
GATCTGTAA GTACTACAAA ACTTAAACTT TACACTGAGT TTTCATCATT GAAGCTATGC CTCCAAT
CTG ACCTCTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TG
TCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAACTTAA TAGAGAAACT CAAGCAGT
TT CCTTCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTATCACAG GTC
TTTGGAA CATTCTTTTG AGAGAAACCT ATTTAGGTCC TTGGTCTGTT TTTCAATCAG GTTGTTTGA
T TTTTGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT ATTTGCCCCT TCTGCCATGT AGGT
TTTGCA AATATTTTCT CTCATTTTCT GGGTTATCTT TTCACTCGGT TGATTGTTTC CTTTGCTGTG
CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTATTT TCCCTTTTAT TGCCTGTGCC TTTGG
TGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAGCTTT ATCCTTCTAT ACACTTCTAG
TAGTTTATGG TTTCAGTTGT TACATTTAGG TTTTCAATTC ATTCTGAGTT GATGTTCCTA CATGGT
GTGA GATAAAGATT TAAATACATA CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC A
ATTGTTAAT TGTTACTCAA GTCTAAGTAG AGGTGGAAAT AATAAACTTT CTTTTTTTTA CTTAAAC
CAC TCTGTGTCAC TGAGCTGATT TCACCTTTAG CCTGATAAAA TCATTGTCCT CTCCACCCTG AT
TCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAA
TC CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC CAG
AGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT TTGTTCCCTG AGCCTGTTGA ATCAAAGTG
C AATTTCTATT CTTTTTGGAA TGTTAAAAAG TGAATCATAA TATTTAAGCA GGTGAACCCA CGAG
TAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC AGACATTAAA GGTACAGATG
TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCTTGAGAC CAATGGGCCT CTCTT
ATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGTTTCTTG TCTCCGAGCC TTCTCCCAGT
AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGT
GACC CCAGCCATGA GGACCCTCGC CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG G
CTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCC
CAG AAGTGGTTGT TTCCCTTGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GC
AGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCA
GT CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT TGA
ACAGAGA GCCAAATAAA CCTGAGAAAC TTTATTTCTC CAAAGACTTG ATTCCAAGAA ACATCTGTG
A AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT AAACAAGTAG ACTT
AGTTGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTTTTAAA AACTGCAGCC AAGCCTGAGG
GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTC
AAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA TTCCTATCGA CTGAGGTTGT TCGTGCTACC
GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTCTTTTT CTTACC
CACT GCTAACTCCA TACTCAATTT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA C
TGCTATTGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGA
AGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTTGCTTTG AG
AGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTT TCCTCATCTC AAATAAAT
GC CTTGTTACAA GATTTCTGTG TTTCCACCTC TTTAATGTGT GATATGTGTC TGTGTCAAGA CAC
TTGGGAT ACACGTACCA AAACGCAAAA TCAAATTTTT GAACAATATA-3' (フラグメント番号 ) (配列番号2477) 5'-GGCBGCBBGG-3' (フラグメント番号1805) (配列番号1818) 5'-GG CTG GGG-3' (フラグメント番号1806) (配列番号1819) 5'-GGGGTCBCC-3' (フラグメント番号1807) (配列番号1820) 5'-GGG TCC TCB TGG CTG GGG TC-3' (フラグメント番号1216) (配列番号1225) 5'-CCT CTC TCC CGT CCT-3' (フラグメント番号1217) (配列番号1226) 5'-CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG
GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT G
GBGGBGGGB GBGCBGG-3' (フラグメント番号1808) (配列番号1821) ヒトマクロファージ炎症性タンパク質-1-アルファ/RANTESレセプター核酸およ びアンチセンスオリゴヌクレオチドフラグメント 5'-GTCTTTGTTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGTTCCGTC CTCTGTGGTG TTT
GGCCCTG CTTCCTTTTG CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC GTTCACCTT
C TGGCACGGAGTT GCATCCCCATA GTCAAACTCT GTGGTCGTGT CATAGTCCTC TGTGGTGTTT G
GAGTTTCCA TCCCGGCTTC TCTCTGGTTC CAAGGGAGB GGGGGCBGCB GTTGGGCCCC BBBGGCCC
TC TCGTTCBCCT TCTGGCBCGG BGTTGCBTCC CCBTBGTCBB BCTCTGTGGT CGTGTCBTBG TCC
TCTGTGG TGTTTGGBGT TTCCBTCCCG GCTTCTCTCT GGTTCCBBGG GB-3' (フラグメント
番号1809) (配列番号1822) 5'-GGGCC CC-3' (フラグメント番号1810) (配列番号1823) 5'-GGGGGCBGC-3' (フラグメント番号1811) (配列番号1824) 5'-CCCGGCTTC-3' (フラグメント番号1812) (配列番号1825) 5'-GTC TTT GTT TCT GGG CTC GTG CC-3' (フラグメント番号1218) (配列番号122
7) 5'-CCB TCC CGG CTT CTC TCT GGT TCC-3' (フラグメント番号1219) (配列番号12
28) 5'-GTC CTCTGT GGT GTT TGG-3' (フラグメント番号1220) (配列番号1229) 5'-CCC TGC TTC CTT TTG CCT GTT-3' (フラグメント番号1221) (配列番号1230)
5'-GAGGGGGCAG CAGTTGGGCC CCAAAGGCCC TCTCGTTCAC CTTCTGGCAC GGAGTTGCAT CCC
CATAGTC AAACTCTGTG GTCGT-3' (フラグメント番号1222) (配列番号1231) 5'-GTCATAGTCCTCTGTGGTGTTTGGAGTTTCCATCCCGGCTTCTCTCTGGTTCCAAGGGA-3' (フラ
グメント番号1223)(配列番号1232) 5'-GBGGGGGCBG CBGTTGGGCC CCBBBGGCCC TCTCGTTCBC CTTCTGGCBC GGBGTTGCBT CCC
CBTBGTC BBBCTCTGTG GTCGTG-3' (フラグメント番号1224) (配列番号1233) 5'-TCBTBGTCCTCTGTGGTGTTTGGBGTTTCCBTCCCGGCTTCTCTCTGGTTCCBBGGGB-3'(フラグ
メント番号1225)(配列番号1234) RANTESアンチセンスオリゴヌクレオチドフラグメント 5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTG
GGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGB
C CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG GCGGTTCTTT CGGG
TGTTTC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGGT CGCTCCGCTC CCGGGTTCGT CTCGCTCTG
T CGCCCCTTCC TTCCTTGTCG TGTTCCTCCC TTCCTTGCCT CT-3' (フラグメント番号181
3) (配列番号1826) 5'-GGGTTGGC-3' (フラグメント番号1814) (配列番号1827) 5'-CGGGG CBG-3' (フラグメント番号1815) (配列番号1828) 5'-CCCGGGTTCG-3' (フラグメント番号1816) (配列番号1829) 5'-GGGTGTGGTG-3' (フラグメント番号1817) (配列番号1830) 5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTG
GGGBGGC BGBTGCBGGB GCGC-3' (フラグメント番号1226) (配列番号1235) 5'-BGBGGGCBGTB GCBBTGBGGB TGBCBGCGBG GCGTGCCGCG GBGBCCTTCB TGGTBCCTGT GG
BGBGGCTG TCGGBGG-3' (フラグメント番号1227) (配列番号1236) 5'-GGGTGTGGTGTCCGCTTGGCGGTTCTTTCGGGTGTTTCTTCTCTGGGTTGGCCTGCTGCTCGTCGTGGT
C-3' (フラグメント番号1228) (配列番号1237) 5'-GCTCCGCTCCCGGGTTCGTCTCGCTCTGTCGCCCCTTCCTTCCTTGTCGTGTTCCTCCCTTCCTTGCCT
CT-3' (フラグメント番号1229) (配列番号1238) 5'-GGGTGTGGTGTCCG-3' (フラグメント番号1230) (配列番号1239) 5'-CTTGGCGGTTCTTTCGGGTG-3' (フラグメント番号1231) (配列番号1240) 5'-TTTCTTCTCTGGGTTGGC-3' (フラグメント番号1232) (配列番号1241) 5'-CTGCTGCTCGTCGTGGTC-3' (フラグメント番号1233) (配列番号1242) 5'-GCTCCGCTCCCGGGTTC-3' (フラグメント番号1234) (配列番号1243) 5'-GTCTCGCTCTGTCGCCC-3' (フラグメント番号1235) (配列番号1244) 5'-CTTCCTTCCTTGTC-3' (フラグメント番号1236) (配列番号1245) 5'-GTGTTCCTCCCTTCCTTGCCTCT-3' (フラグメント番号1237) (配列番号1246) 5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTG
GGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGB
C CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GG-3' (フラグメント番号1818) (配列番
号1831) ヒトムスカリン様アセチルコリンレセプターHM1*核酸およびアンチセンスオリ ゴヌクレオチドフラグメント 5'-GCTGCCCGGC GGGGTGTGCG CTTGGCGCTC CCGTGCTCGG TTCTCTGTCT CCCGGTCCCC CTT
GCCTGGC GTCTCGGGCC TTCGTCCTCT TCCTCTTCTT CCTTCCGCTC CGTGGGGGCT GCTTGGTGG
G GGCCTGTGCCT CGGGGTCCCG GGGCTTCTGG CCCTTGCCGT TCATGGTGGC TAGGTGGGGC GTT
CBTGGTG GCTBGGTGGG GC-3'(フラグメント番号1819)(配列番号1832) 5'-GGTGGGGC-3' (フラグメント番号1820) (配列番号1833) 5'-GCCCGGCGGGG-3' (フラグメント番号1821) (配列番号1834) 5'-CGG GGC TTC TGG CCC-3' (フラグメント番号1822) (配列番号1835) 5'-GTT CBT GGT GGC TBG GTG GGG C-3' (フラグメント番号1238) (配列番号1247
) 5'-GCT GCC CGG CGG GGT GTG CGC TTG GC-3' (フラグメント番号1239) (配列番
号1248) 5'-GCT CCC GTG CTC GGT TCT CTG TCT CCC GGT-3' (フラグメント番号1240) (配
列番号1249) 5'-CCC CCT TTG CCT GGC GTC TCG G-3' (フラグメント番号1241) (配列番号1250
) 5'-GCC TTC GTC CTC TTC CTC TTC TTC CTT CC-3' (フラグメント番号1242) (配
列番号1251) 5'-GCT CCG TGG GGG CTG CTT GGT GGG GGC CTG TGC CTC GGG GTC C-3' (フラグ
メント番号1243) (配列番号1252) 5'-CGG GGC TTC TGG CCC TTG CC-3' (フラグメント番号1244) (配列番号1253) 5'-GTT CAT GGT GGC TAG GTG GGG C-3' (フラグメント番号1245) (配列番号1254
) ヒトムスカリン様アセチルコリンレセプターHM3*核酸およびアンチセンスオリ ゴヌクレオチドフラグメント 5'-GGG GTG GGT BGG CCG TGT CTG GGGGTT GGC CBT GTT GGT TGC CTCT TGG TGG T
GC GCC GGG CGCG TCT TGG CTT TCT TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT
GGGCT CCT CCC GGG CGG CCT CCC CGG GCG GGG GCT TCT TGGCG CTG GCG GGG GGG
CCT CCTGCT CTG TGG CTG GGC GTT CCT TGG TGT TCT GGG TGGTGG CGG GCG TGG TG
G CCT CTG TGGGGG CCC GCG GCT GCB GGG GTTG CCT GTC TGC TTC GTCCTT TGC GCT
CCC GGG CCG CCGGG GTG GGT AGG CCG TGT CTG GGGGTT GGC CAT GTT GGT TGC CG
GG CCC GCG GCT GCA GGG G-3' (フラグメント番号1823) (配列番号1836) 5'-CCC GGG CGG-3' (フラグメント番号1824) (配列番号1837) 5'-G GCG GGG GGG CC-3' (フラグメント番号1825) (配列番号1838) 5'-CCC GGG CCG CC-3' (フラグメント番号1826) (配列番号1839) 5'-GG CCG TGT-3' (フラグメント番号1827) (配列番号1840) 5'-GGG GTG GGT BGG CCG TGT CTG GGG-3' (フラグメント番号1246) (配列番号12
55) 5'-GTT GGC CBT GTT GGT TGC C-3' (フラグメント番号1247) (配列番号1256) 5'-TCT TGG TGG TGC GCC GGG C-3' (フラグメント番号1248) (配列番号1257) 5'-GCG TCT TGG CTT TCT TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT GG-3'(フ
ラグメント番号1249)(配列番号1258) 5'-GCT CCT CCC GGG CGG CCT CCC CGG GCG GGG GCT TCT TG-3' (フラグメント番
号1250) (配列番号1259) 5'-GCG CTG GCG GGG GGG CCT CCT CC-3' (フラグメント番号1251) (配列番号126
0) 5'-GCT CTG TGG CTG GGC GTT CCT TGG TGT TCT GGG TGG C-3' (フラグメント番
号1252) (配列番号1261) 5'-TGG CGG GCG TGG TGG CCT CTG TGG TGG-3' (フラグメント番号1253) (配列番
号1262) 5'-GGG CCC GCG GCT GCB GGG G-3' (フラグメント番号1254) (配列番号1263) 5'-TTG CCT GTC TGC TTC GTC-3' (フラグメント番号1255) (配列番号1264) 5'-CTT TGC GCT CCC GGG CCG CC-3' (フラグメント番号1256) (配列番号1265) 5'-GGG GTG GGT AGG CCG TGT CTG GGG-3' (フラグメント番号1257) (配列番号12
66) 5'-GTT GGC CAT GTT GGT TGC C-3' (フラグメント番号1258) (配列番号1267) 5'-GGG CCC GCG GCT GCA GGG G-3' (フラグメント番号1259) (配列番号1268) ヒトフィブロネクチン*アンチセンスオリゴヌクレオチドフラグメント 5'-CGG TTT CCT TTG CGG TC TTG GCC CGG GCT CCG GGT G CCC GCC CGC CCG CCG
GCC GCC GC CCC GCC GGG CTG TCC CCG CCC CGC CCC GGC CCG GGG CGC GGG GG CG
G CCC TCC CGC CCC TCT GG GCC GGC GCG GGC GTC GG CCG CTC GCG CCT GGG GTT
CCC TCT CCT CCC CCT GTG C GCC TGC CTC TTG CTC TTCTGC GTC CGC TGC CTT CTC
CC CTC TCC TCG GCC GTT GCC TGT GC TGT CCG TCC TGT CGC CCT TCC GTG GTG C
TGT TGT CTC TTC TGC CCT C GGT GTG CTG GTG CTG GTG GTG GTG CCT CTG CCC G
TG CTC GCCCTG CCT GGG CTG GCC TCT TCG GGT GTG GCT TTG GGG CTC TCT TGG TT
G CCC TTT CTT CTC GTG GTG CCT CTC CTC CCT GGC TTG GTC GT TGT CTG GGG TGG
TGC TCC TCT CCC TTT CCC TGC TGG CCG TTT GT CCT GTT TTC TGT CTT CCT CT T
TC CTC CTG TTT CTC CGT TTG GCT TGC TGC TTG CGG GGC TGT CTC C CTT GCC CCT
GTG GGC TTT CCC TGG TCC GGT CTT CTC CTT GGG GGT C GCC CTT CTT GGT GGG C
TGGCT CGT CTG TCT TTT TCC TTC C TGG GGG TGG CCG TTG TGG GCG GTG TGG TCC
GCC T TGC CTC TGC TGG TCT TTC-3' (フラグメント番号1828) (配列番号1841) 5'-GGCCCGGGC-3' (フラグメント番号1829) (配列番号1842) 5'-GCCGGCGCGGGCG-3' (フラグメント番号1830) (配列番号1843) 5'-GCCTGGGCTGGCC-3' (フラグメント番号1831) (配列番号1844) 5'-GGGGG TGGCCG-3' (フラグメント番号1832) (配列番号1845) 5'-GG GGG TGG CCG TTG TGG GCG G-3' (フラグメント番号1833) (配列番号1846)
5'-CGG TTT CCT TTG CGG TC-3' (フラグメント番号1260)(配列番号1269) 5'-TTG GCC CGG GCT CCG GGT G-3' (フラグメント番号1261)(配列番号1270) 5'-CCC GCC CGC CCG CCG GCC GCC GC-3' (フラグメント番号1262)(配列番号1271
) 5'-CCC GCC GGG CTG TCC CCG CCC CGC CCC-3' (フラグメント番号1263)(配列番
号1272) 5'-GGC CCG GGG CGC GGG GG-3' (フラグメント番号1264)(配列番号1273) 5'-CGG CCC TCC CGC CCC TCT GG-3' (フラグメント番号1265)(配列番号1274) 5'-GCC GGC GCG GGC GTC GG-3' (フラグメント番号1266)(配列番号1275) 5'-CCG CTC GCG CCT GGG GTT CCC TCT CCT CCC CCT GTG C-3' (フラグメント番
号1267)(配列番号1276) 5'-GCC TGC CTC TTG CTC TTC-3' (フラグメント番号1268)(配列番号1277) 5'-TGC GTC CGC TGC CTT CTC CC-3' (フラグメント番号1269)(配列番号1278) 5'CTC TCC TCG GCC GTT GCC TGT GC-3' (フラグメント番号1270)(配列番号1279)
5'-TGT CCG TCC TGT CGC CCT TCC GTG GTG C-3' (フラグメント番号1271)(配列
番号1280) 5'-TGT TGT CTC TTC TGC CCT C-3' (フラグメント番号1272)(配列番号1281) 5'-GGT GTG CTG GTG CTG GTG GTG GTG-3' (フラグメント番号1273)(配列番号128
2) 5'-CCT CTG CCC GTG CTC GCC-3' (フラグメント番号1274)(配列番号1283) 5'-CTG CCT GGG CTG GCC TCT TCG GGT-3' (フラグメント番号1275)(配列番号128
4) 5'-GTG GCT TTG GGG CTC TCT TGG TTG CCC TTT-3' (フラグメント番号1276)(配
列番号1285) 5'-CTT CTC GTG GTG CCT CTC CTC CCT GGC TTG GTC GT-3' (フラグメント番号12
77)(配列番号1286) 5'- TGT CTG GGG TGG TGC TCC TCT CCC-3' (フラグメント番号1278)(配列番号12
87) 5'-TTT CCC TGC TGG CCG TTT GT-3' (フラグメント番号1279)(配列番号1288) 5'-CCT GTT TTC TGT CTT CCT CT-3' (フラグメント番号1280)(配列番号1289) 5'-TTC CTC CTG TTT CTC CGT-3' (フラグメント番号1281)(配列番号1290) 5'-TTG GCT TGC TGC TTG CGG GGC TGT CTC C-3' (フラグメント番号1282)(配列
番号1291) 5'-CTT GCC CCT GTG GGC TTT CCC-3' (フラグメント番号1283)(配列番号1292) 5'-TGG TCC GGT CTT CTC CTT GGG GGT C-3' (フラグメント番号1284)(配列番号1
293) 5'-GCC CTT CTT GGT GGG CTG-3' (フラグメント番号1285)(配列番号1294) 5'-GCT CGT CTG TCT TTT TCC TTC C-3' (フラグメント番号1286)(配列番号1295)
5'-TGG GGG TGG CCG TTG TGG GCG GTG TGG TCC GCC T-3' (フラグメント番号128
7)(配列番号1296) 5'-TGC CTC TGC TGG TCT TTC-3' (フラグメント番号1288)(配列番号1297) ヒトインターロイキン-1(IL-1)核酸およびアンチセンスオリゴヌクレオチドフ ラグメント 5'-AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC TGT
GGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA TTAAATCAG
A ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA TTATTTACAA TTAA
ACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC CTCCCAGATC CATGCTTTTT
TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT GCCCACACTG GACTAAAACT CTGGG
CCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA GCTGGGACTA CAGGGGCATG CCATCACACC
TAGTTCATTT CCTCTATTTA AAATATACAT GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATT
TGCT AAGAGTCTGG TGTTCTACCA CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA A
TTCTTTAAT AATAGTAACC AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTT
CTC CCAATCTCCA TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GG
GCTTGCAC ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTC
TC TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGC
TCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA CTTCTTTGT
G CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC ACCCCAAACT CTGA
GGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT GGCTCATTTT CCCTCAAAAG
TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA GCACAATCAA CAAATTCAGC CAGAA
CACAA CTACAGCTAC TATTAGAACT ATTATTATTA ATAAATTCCT CTCCAAATCT AGCCCCTTGA
CTTCGGATTT CACGATTTCT CCCTTCCTCC TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTC
TAAG ACTACATGTT TGTCATCTTA TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT C
TGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGT
TGA ATGAACATAG AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC AC
TTGTAGCC ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTA
AG CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CAT
CTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC ATTGCCTTC
T CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT GTGACCTAGA ATTA
CAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT GATTCGTTTT ACTGAGGGAC
GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCT
CTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT TTCCAACTCT GTCTCTCTCT TACCTCTGTG
TAAGGCAAAT ACCTTATTCT TGTGGTGTTT TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCT
GTTC TGGCAATACA TTAGGTTGGG CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA A
GTTTACGAT CTAATAAAGG AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAA
AAT GCTGAATGTG GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CC
TCACAGAT ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCA
AG ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA TTT
ATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA GTGGCCAGC
A TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC AGAG
AAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA TTGGCAGGGA GACCGCCATT
TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGC
CTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG GTTTTACTGG TCCATTCTCA GGAAAACTTG
ATCTCATTCA GGAACAGGAA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAA
ATCT CACTCAGATG TAGAAGAAAG GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC T
AACATGATG TTTCCATTAT CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGA
TAT TTTACTAAGT ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT AT
AATCTATT TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACA
TT CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA AAG
CACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT GAATTACTC
T ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG CCATGTGTAT GTGT
GTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAATTA
CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCT
CTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG GGACTGCTAT TCTTACACAG TGGTTTCTTC
ATCCAAAGAG AACAGCAATG ACTTGAATCT TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGA
GACC TGTCTTTCAT TATAAGTGAG ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC T
TCTCCCAGA ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCAT
CAG GATGTTAGTT ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TA
ACGTGATG TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATG
AA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGT
TATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGCTTT
A AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC AGATTTTTAA CCTC
CTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT TAACCTATTT AGTTACAACA
TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT AAAAAAATCA TCTTTTTATC CTGGA
AGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTTACCTA
AGACCAGAAT GGAGATCCTC CTCACTACCT CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATT
CCCT GACCATGAAC AGCCTCTCAG CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA A
GCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTA
AAA CATCCAAGCT TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AG
AAGAGACG GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCA
GA GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC AGT
AGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT AGTCTGGTA
A CTATACAGAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATC
GAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG TCGTGTGACT TTTAGCCTTT
CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CCTTG
GTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC TCTACTGTAA AATGGAGATA ATCAGAATCC
CCCACTCATT GGATTGTTGT AAAGATTAAG AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCT
CCTG ACTGTTATAA AGATTAAATG AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG T
ACAAAGTAA GCACCCAATA AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTTTT
TTG AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AA
GCTCTGCC TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCA
CC CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT CCA
TCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCC
C GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC AGCAATACTA ATTT
ATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT CATTTTACAT AAAAGGAAAC
TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCT
AATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT CTCCTCCATC CCTTTACTGT ACAAGCCTCC
ACATGAACTA TAAACCCAAT ATTCCTGTTT TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCT
AGAA GGTTTTAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT T
ACTACTGCC AGCACTATGG TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAA
ATA TGTCTAACAT CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GT
ATTGAGGA CATTTTAGAG TGCCCGTTTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATA
AA TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC CCA
GAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT ATATAATTA
T TTTTAATGCA TTCATTTTTT TCTCAGAGTG CATTCGTTTG AAAACATAGA CGGGAAATAC TGGT
AGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA AGTTGCACAA ATAGTCTCTA
AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTTAAAA AGAAGCACAT AAGCAACAAC AAGGA
TAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT TTCACTTCTC TTTGCTTCCT CATCTGGATT
GGAATATTCC TAATACCCCC TCCAGAACTA TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTG
TGTT TGTACATAGA CATTAATCTG CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC A
TCACCTTTT AGCTTCCTGA GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATC
CTG AATGACGCCC TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TT
ACATAATC TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTT
CA TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGG
TTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAA
G GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG AGTAAAGGGT TGTG
CACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TCAGACATTC TTACCCTCAA TTTTAAAACT
GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT ACCCAGAAGC CAATGAAGAA CAATC
ACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA AGTAACACCA AACCAGGAAG ATCTTTATTA
TCTCTGATAA CATATTTGTG AGGCAAAACC TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGT
TTAG TGTCCAAAAA CTTTTATCAC ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC A
GTATACATA TTTTCAAAGG TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTG
GAT GCACTTCAGC TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TA
CTTAATAT TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCA
CT AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC AAA
TATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC CAAAGAGGA
A TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT TCTGTAAGTA AAAA
CTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA
GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGA
TTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA CGTAGAAAAT TCTAAGAACA TTAACCAAGT
ATTTACCTGC CTAGTGAGTG TGGAAGACAT TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCT
GACT TCCAGGTATT TACACCATAG GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC A
CACACACAC ACCATGCACA CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTAC
TTT CTTTTTGGTT CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG AT
GATGCTAA AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAA
GA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT CAT
ATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT TCCTTCCTA
C CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATG
AGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT CCTTTCCCTG CCTGACCTTA
TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC TTTACTGACA TCTATTATCT GACCT
ACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT
CAGAGAGGAT TAATCACCTG CCAATGGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGG
GCCT GCTGCTTCCA GTTCCCCTCT CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG T
CTCCACTAC CACTTTCCCC CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGAT
AAG TAGGTGACTC AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TG
CCTGCCTG TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGA
AC TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA GTG
TGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT GGAAAACAG
A CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAA
GATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCTT GTGAGATGAG
AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT GGGTAGGACA TTCAGAGGAG GGGGC
GGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT
TTGGGTAGGA CATTCAGAGG AGGGGGCGGG TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGG
AGGG GGCGGGTCGT GGTTGTGGGT TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA C
AACTTCAAG ATGGTAAAGG ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTG
AGA AGGAGGAAAA ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TA
CAATGAAA ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAAT
AG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC AGT
CATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT TTGGAGATA
G AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGG
TTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC AAAAGTATAT TTACTTGCTT
TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA TTTGAAATCT ATTTTTCCAT AAAAG
TATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTTTA
CTGATATACT TAGGAATTTT GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCA
ATTG TTGACTTAAA TACTGAGATA AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA T
TTGTTCACT TGGAGATCAA AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAA
AAT GTCTTAGGCC TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CA
GTAAGATA CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAA
AT CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA TGA
ACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT TCTCATGAA
G GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT CTAACAGAAT TCTC
TTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC
TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT CAGTTGCCCA TCCAAACTTG TTTAT
TGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA
TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATA
TGTA CCATGTACAT GAAGAAGCTA AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC C
TTGTAATTC TAAATGAATG TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGT
TAT TTAAAGAACA CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA AT
TTTAGGAG GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAA
AT TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC TAG
GATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC TTAATCAAA
T AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT AATACCTAAG CCTT
CCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA AAATACTTCT CGAAGCCGAG
CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT TATTATTTAT ATATGTATTT ATAAA
TATAT TTAAGATAAT TATAATATAC TATATTTATG GGAACCCCTT CATCCTCTGA GTGTGACCAG
GCATCCTCCA CAATAGCAGA CAGTGTTTTC TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCA
TTTT GGTCCAAGTT GTGCTTATCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT G
TAATCATAT AATAAATGTA CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTG
CCA TTAAACTTAC CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TA
AAATTAGA TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATG
TA ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA ACA
ATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT CTGACACAT
A GTTATTCATT GCCTTAATCA TTATTTTACT GCATGGTAAT TAGGGACAAA TGGTAAATGT TTAC
ATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT TTATATTTTT TTCTCCTCTT
TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA ATATTTCCGG GTTCACTTAA AGCTC
ATATT ACACATACAC AAAACATGTG TTCCCATCTT TATACAAACT CACACATACA GAGCTACATT
AAAAACAACT AATAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA CTTTGGGAGG ACCAAC
CTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCATTGCTCA A
GTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGC
AAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CT
GGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTT
CA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CAC
AGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCT
T CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTC
CGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG
GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGA
CAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG
ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGC
GATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA C
TGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAG
GAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GT
GCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCTAT
AG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGA
TCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTG
A GCCAGGCCTC TCTCACCTCT CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTT
GGTTCT AAGAAACCCT CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA
TTTATTTGTT TGTTTGTTTT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGT
CTGTA AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT
AAATCAAGTC CTTTAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAATA TTTATA
AATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG AGAAAGAAAG AGAG
AGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG
TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG ATCCTGTGGA GGCANNCAGA GGAGT
CCCCT AGGCCACCCA GACAGGGCTT TTAGCTATCT GCAGGCCAGA CACCAAATTT CAGGAGGGCT
CAGTGTTAGG AATGGATTAT GGCTTATCAA ATTCACAGGA AACTAACATG TTGAACAGCT TTTAGA
TTTC CTGTGGAAAA TATAACTTAC TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT A
CTGGGAGCC AAATTAAAAA TCAGAAGGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TTTCCCA
CAG TAGAACCTAT TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC TTGGATAATG CA
GAGCGAGC ACGATACCTG GCACATACTA ATTTGAATAA AATGCTGTCA AATTCCCATT CACCCATT
CA AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA AAA
GATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT TCAACTCAGT GCTATAAGAA GTGTTACAG
G CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTTGGG AGGCCGAGGC GGGCAGATCA CAAG
GTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT
TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG AATGG
TGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA
CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAA
GGAG GGTGTTCCTA CACTCCAGGC ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA G
GGCTCCCCT GGGCAGATCC CTGGAGCAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAA
CTC TTGGTATTAC CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TT
TCAGAGTT CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGA
TT GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC AAC
TCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT CAATTTTCT
C CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA GACC
CACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC CCATTTATCC ATCTGTAAGT
GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCTG
TGTGT CTTCCACTTT GTCCCACATA TACTAAATTT AAACATTCTT CTAACGTGGG AAAATCCAGT
ATTTTAATGT GGACATCAAC TGCACAACGA TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATAC
ATTT GCAAAATGTG TCATAGTTTG CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT T
TATTAGTCC CCTCCCCTAA GAAGCTTCCA CCAATACTCT TTTCCCCTTT CCTTTAACTT GATTGTG
AAA TCAGGTATTC AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CA
GCGAGGGA GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGAT
TC TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA GGG
AGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT TCTTTCTCT
G TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAATG CCAGGTGTAA TATA
ATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT AACAGCTGAC ACCCTAAAGG
TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC ATTGCTAGTT GGGGTTTGGT TTAGC
AAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT CACACATTCA TTCATTTACT CAGAGATCAT
TTCTTTGCAT GACTGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGG
AAGT CACTCATTTT CTCCTTTTTA CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT C
GCCAGTGAA ATGATGGCTT ATTACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTC
CTC TTTCAAGAGT AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TC
AGTGGCAA ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGC
CT TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG AGA
AAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG AGGGAGAGC
T CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC AGGGAGCACC AGGG
TGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC ATATCACTGT GAAACTTGCC
AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT TTCTTATGAA CAGTCAAGTC TTGTA
CACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA TAATTGAGAC ATGTCCCTGT TTTTATTACA
GTGGCAATGA GGATGACTTG TTCTTTGAAG CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGG
TTTA ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC A
CTTTGATGC CATGGTATTT TGTTTTAGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACC
ACT TGCTGACCTG GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GG
CCACACTT GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCA
AG TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG AGT
TAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG TAGAATAGT
T TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG AATT
GAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT CATTTTACCC GCTTTGGACC
TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG ATTCCAGCAT CCTGCAACCT CCAGT
TCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG GGCAGCAAAT GGTCATTTTT CAGACTCATC
CTTACAAAGA GCCATGTTAT ATTCCTGCTG TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCT
AGGT GCCCAGCCAT CAGCCTAGCT AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG C
TTTATTTTA TTCCAGTTTG TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAA
ACA TATTTCTTTA GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC AT
TGGCTTGT CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGG
AA ATTCTCTCCT GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC CTT
TGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCTTCTCTG AATAAGAGG
A AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGCCT ATGAGACAGT GTTA
TGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT GAGTGAGCAT AGGTGAATGG
AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAG
ATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG
GGATTTATTC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCT
ACCT GCTGTGTGCC CTTGAGTACA CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT A
TTTTATTTT ATTTTATTTT GTTTTGTTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGT
TGC CCAGGCTGGA GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTCAA GC
GATTCTCC TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATT
TT TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC CTA
AATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC GCCTGGCCC
A GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTCCT CTCTGAGCTT TCTA
CTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG CTCCCTCCCT CGCTCTCTCC
GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTCCG
ACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TCAGTTGTTG TGGCCATGGA CAAGCTGAGG
AAGATGCTGG TTCCCTGCCC ACAGACCTTC CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATC
TTTG AAGAAGGTAG TTAGCCAAGA GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT C
AAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGA
CAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG AT
CTTGATGG CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCAC
CA GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT CTG
TTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCA
G TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCATCA GACTTTGACC GTAT
ATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA CGAGGCCTGC CCTTCTGATT
TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT CTTCTTCGAC ACATGGGATA ACGAG
GCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG
CTTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACA
AGGT AAATGGAAAC ATCCTGGTTT CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT T
TAAACAAAG TAGAAAGTTA ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGA
ATA TACAAACTTT GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GG
AGTGTGAC CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGG
CA TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT GTG
GGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTC
C CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT TCCTTGTAGG GAAA
TTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA AAGTTTCAAG TGCGGTGAAC
CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA GGAGT
GTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC CTCACTCAGG GGGAAGCTAT TTGCTCTCAG
CCAGGCCAAG AAAATCCTGT TTCTTTGGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGA
CACT GCTGTGACTG AGGAAGATCA AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC C
TCTCCTCTC CCAGTTTCTT CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTC
TGG CAGAAGTACA GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TG
GATGGGCA CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGT
AG ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA GGG
GAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AAGTTATCCT GTGTCTTAG
G CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC CTACTCTCGG GGCT
AGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC CCTTCTTTCT TCAGTGGTGT
TCTCCATGTC CTTTGTACAA GGAGAAGAAA GTAATGACAA AATACCTGTG GCCTTGGGCC TCAAG
GAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA TGATAAGCCC ACTCTACAGC TGGAGGTAAG
TGAATGCTAT GGAATGAAGC CCTTCTCAGC CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTC
TCCC CGCCCCCATC CCTAGGAAAA GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA A
ATAAATTTA ACATAATTTT TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTT
GCC GATGTTATTA TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CT
CATTTGAT AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCC
AA AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC ATT
CTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA GCTCTAGCT
T AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC AGCATTTGGC ACTA
AGTTTT AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT TGGGGGCCCA GTTACAACTC
AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT CCTTTCTGGC CAACCCAAAG AACAT
CTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA AAATTCTTCT TTCTCTTTCG CTGCAGAGTG
TAGATCCCAA AAATTACCCA AAGAAGAAGA TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCA
ATAA CAAGCTGGAA TTTGAGTCTG CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA A
AACATGCCC GTCTTCCTGG GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTT
GTG TCTTCCTAAA GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GC
TGGCAGAA AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACC
AA TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCA
GCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC TCTCCTACT
C ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC CCTCTGTCAT TCGC
TCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT GTTTGTTTGT TTTGATTCAT
TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGAG CCTAGTTTTT AATAG
CTATG GAATCAATTC AATTTGGACT GGTGTGCTCT CTTTAAATCA AGTCCTTTAA TTAAGACTGA
AAATATATAA GCTCAGATTA TTTAAATGGG AATATTTATA AATGAGCAAA TATCATACTG TTCAAT
GGTT CTGAAATAAA CTTCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG G
ATTGACACT GACAGTAAGC AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTG
AGT GCTGCAAGTA CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TA
TTTCGTTG TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGG
AG TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG CAA
GCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAG
A GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGG
AGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGATTTC
CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT AATCCCAGCA CTTTGGGTGG CAGGG
GCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT
CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAG
CTAC TTGGGAAGCT GACACTGGAG GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA T
CCGTTGACC TGCAGGTCGA C ACAAACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATT
CTCTT CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC
AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAA
CAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA T
CTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCT
GAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CT
TCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCAC
CT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCA
TATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCC
T TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCT
GTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA
TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGG
AATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC
TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAA
AGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG G
AACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTG
CCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TT
CAGGGCCA ATCCCAGCCC TTTTGTTGAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCG
CC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TTC
TGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG TTTGTTTGTT TTGATTCATT GGTCTAATT
T ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATC
AATTCA ATTTGGACTG GTGTGCTCTC TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG
CTCAGATTAT TTAAATGGGA ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAA
TAAAC TTCACT CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAG
AAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG
AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGA
CTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA CCGTATATCC
CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCA
AAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG CAGTCTTTTG TAACCATGCC C
AATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCTTT
TCT GAGGATGATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GG
TTCCTTTA GTTATAAGTC ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGC
CA TTGCCATTTT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAA
AGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGA
T GGAAAAGCGA ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGTGA AAAT
GAAGAA GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT
GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAAC
ATCCA AGCTTACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT CTGAAGAAGA
GACGGTTGAG TTTAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGG
AAGA AATCATCAAG CCTAGGTCAG CACCTTTTAG CTTCCTGAGC AATGTGAAAT ACAACTTTAT G
AGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC AATCAAAGTA TAATTCGAGC CAATGAT
CAG TACCTCACGG CTGCTGCATT ACATAATCTG GATGAAGCAG TGAAATTTGA CATGGGTGCT TA
TAAGTCAT CAAAGGATGA TGCTAAAATT ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGT
GA CTGCCCAAGA TGAAGACCAA CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCA
CAGGTAG TGAGACCAAC CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAG
T TGCCCATCCA AACTTGTTTA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCA
CCCTCT ATCACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT
TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT AGTCA
TTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT AAGAGTGGAA
CCAACACTAA CATATAATGT TGTTATTTAA AGAACACCCT ATATTTTGCA TAGTACCAAT CATTTT
AATT ATTATTCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC T
CTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA GCAGTTG
AAA CAAGAAGCCA CAGACCTAGG ATTTCATGAT TTCATTTCAA CTGTTTGCCT TCTGCTTTTA AG
TTGCTGAT GAACTCTTAA TCAAATAGCA TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATG
GA GGGAATAATA CCTAAGCCTT CCTGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTG
GTAAAAT ACTTCTCGAA GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTAT
T ATTTATATAT GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCC
TTCATC CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT
TTGATTTCAT TAATACAGGG CATTTTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGC
ATTCT AGTACTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG AGCCAGTAAT
TGGTCCGATC TTTGACTCTT TTGCCATTAA ACTTACCTGG GCATTCTTGT TTCATTCAAT TCCACC
TGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTTG ACAACCATAG ACCACTGTTA T
CAAAACTTT CTTTTCTGGA ATGTAATCAA TGTTTCTTCT AGGTTCTAAA AATTGTGATC AGACCAT
AAT GTTACATTAT TATCAACAAT AGTGATTGAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC TT
GCAAGTGA GGGAGTCATT TCATTGGCGT TTGAGTCAGC AAAGAAGTCA AG AGCTGCCAGC CAGAG
AGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT
TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTC
TGAA TCAGAAATCC TTCTATCATG TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC T
GTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTA
GTA GCAACCAACG GGAAGGTTCT GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GA
TGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAG
CT TCCTGAGCAA TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACG
CCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGG
A TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC CGTG
ATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG
AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCTTCTTC TGGGA
AACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA CTTGTTTATT GCCACAAAGC
AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT CACTGACTTT CAGATACTGG AAAACC
AGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG TGCAGTGTTG ACAGTTCATA TGTACCATGT A
CATGAAGAA GCTAAATCCT TTACTGTTAG TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAA
ATG AATGTTTACA CTCTTTGTAA GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AA
CACCCTAT ATTTTGCATA GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACC
AG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATA
AGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATT
T CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA AGTT
TCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA
GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAAGC CGAGCCTCAA GATGA
AGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT ATTTATAAAT ATATTTAAGA
TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT CTGAGTGTGA CCAGGCATCC TCCACA
ATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT GATTTCATTA ATACAGGGCA TTTTGGTCCA A
GTTGTGCTT ATCCCATAGC CAGGAAACTC TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAAT
AAA TGTACATTAA TTACCTTGAG CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TT
ACCTGGGC ATTCTTGTTT CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAA
CT CAACTTTGAC AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTT
TCTTCTA GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGAT
A GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG-3' (フラグメント番
号 )(配列番号2517) 5'-AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC TGT
GGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA TTAAATCAG
A ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA TTATTTACAA TTAA
ACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC CTCCCAGATC CATGCTTTTT
TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT GCCCACACTG GACTAAAACT CTGGG
CCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA GCTGGGACTA CAGGGGCATG CCATCACACC
TAGTTCATTT CCTCTATTTA AAATATACAT GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATT
TGCT AAGAGTCTGG TGTTCTACCA CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA A
TTCTTTAAT AATAGTAACC AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTT
CTC CCAATCTCCA TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GG
GCTTGCAC ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTC
TC TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGC
TCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA CTTCTTTGT
G CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC ACCCCAAACT CTGA
GGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT GGCTCATTTT CCCTCAAAAG
TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA GCACAATCAA CAAATTCAGC CAGAA
CACAA CTACAGCTAC TATTAGAACT ATTATTATTA ATAAATTCCT CTCCAAATCT AGCCCCTTGA
CTTCGGATTT CACGATTTCT CCCTTCCTCC TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTC
TAAG ACTACATGTT TGTCATCTTA TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT C
TGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGT
TGA ATGAACATAG AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC AC
TTGTAGCC ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTA
AG CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CAT
CTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC ATTGCCTTC
T CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT GTGACCTAGA ATTA
CAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT GATTCGTTTT ACTGAGGGAC
GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCT
CTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT TTCCAACTCT GTCTCTCTCT TACCTCTGTG
TAAGGCAAAT ACCTTATTCT TGTGGTGTTT TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCT
GTTC TGGCAATACA TTAGGTTGGG CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA A
GTTTACGAT CTAATAAAGG AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAA
AAT GCTGAATGTG GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CC
TCACAGAT ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCA
AG ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA TTT
ATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA GTGGCCAGC
A TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC AGAG
AAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA TTGGCAGGGA GACCGCCATT
TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGC
CTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG GTTTTACTGG TCCATTCTCA GGAAAACTTG
ATCTCATTCA GGAACAGGAA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAA
ATCT CACTCAGATG TAGAAGAAAG GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC T
AACATGATG TTTCCATTAT CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGA
TAT TTTACTAAGT ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT AT
AATCTATT TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACA
TT CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA AAG
CACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT GAATTACTC
T ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG CCATGTGTAT GTGT
GTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAATTA
CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCT
CTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG GGACTGCTAT TCTTACACAG TGGTTTCTTC
ATCCAAAGAG AACAGCAATG ACTTGAATCT TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGA
GACC TGTCTTTCAT TATAAGTGAG ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC T
TCTCCCAGA ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCAT
CAG GATGTTAGTT ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TA
ACGTGATG TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATG
AA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGT
TATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGCTTT
A AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC AGATTTTTAA CCTC
CTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT TAACCTATTT AGTTACAACA
TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT AAAAAAATCA TCTTTTTATC CTGGA
AGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTTACCTA
AGACCAGAAT GGAGATCCTC CTCACTACCT CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATT
CCCT GACCATGAAC AGCCTCTCAG CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA A
GCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTA
AAA CATCCAAGCT TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AG
AAGAGACG GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCA
GA GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC AGT
AGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT AGTCTGGTA
A CTATACAGAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATC
GAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG TCGTGTGACT TTTAGCCTTT
CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CCTTG
GTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC TCTACTGTAA AATGGAGATA ATCAGAATCC
CCCACTCATT GGATTGTTGT AAAGATTAAG AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCT
CCTG ACTGTTATAA AGATTAAATG AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG T
ACAAAGTAA GCACCCAATA AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTTTT
TTG AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AA
GCTCTGCC TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCA
CC CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT CCA
TCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCC
C GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC AGCAATACTA ATTT
ATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT CATTTTACAT AAAAGGAAAC
TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCT
AATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT CTCCTCCATC CCTTTACTGT ACAAGCCTCC
ACATGAACTA TAAACCCAAT ATTCCTGTTT TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCT
AGAA GGTTTTAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT T
ACTACTGCC AGCACTATGG TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAA
ATA TGTCTAACAT CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GT
ATTGAGGA CATTTTAGAG TGCCCGTTTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATA
AA TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC CCA
GAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT ATATAATTA
T TTTTAATGCA TTCATTTTTT TCTCAGAGTG CATTCGTTTG AAAACATAGA CGGGAAATAC TGGT
AGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA AGTTGCACAA ATAGTCTCTA
AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTTAAAA AGAAGCACAT AAGCAACAAC AAGGA
TAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT TTCACTTCTC TTTGCTTCCT CATCTGGATT
GGAATATTCC TAATACCCCC TCCAGAACTA TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTG
TGTT TGTACATAGA CATTAATCTG CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC A
TCACCTTTT AGCTTCCTGA GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATC
CTG AATGACGCCC TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TT
ACATAATC TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTT
CA TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGG
TTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAA
G GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG AGTAAAGGGT TGTG
CACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TCAGACATTC TTACCCTCAA TTTTAAAACT
GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT ACCCAGAAGC CAATGAAGAA CAATC
ACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA AGTAACACCA AACCAGGAAG ATCTTTATTA
TCTCTGATAA CATATTTGTG AGGCAAAACC TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGT
TTAG TGTCCAAAAA CTTTTATCAC ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC A
GTATACATA TTTTCAAAGG TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTG
GAT GCACTTCAGC TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TA
CTTAATAT TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCA
CT AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC AAA
TATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC CAAAGAGGA
A TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT TCTGTAAGTA AAAA
CTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA
GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGA
TTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA CGTAGAAAAT TCTAAGAACA TTAACCAAGT
ATTTACCTGC CTAGTGAGTG TGGAAGACAT TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCT
GACT TCCAGGTATT TACACCATAG GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC A
CACACACAC ACCATGCACA CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTAC
TTT CTTTTTGGTT CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG AT
GATGCTAA AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAA
GA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT CAT
ATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT TCCTTCCTA
C CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATG
AGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT CCTTTCCCTG CCTGACCTTA
TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC TTTACTGACA TCTATTATCT GACCT
ACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT
CAGAGAGGAT TAATCACCTG CCAATGGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGG
GCCT GCTGCTTCCA GTTCCCCTCT CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG T
CTCCACTAC CACTTTCCCC CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGAT
AAG TAGGTGACTC AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TG
CCTGCCTG TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGA
AC TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA GTG
TGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT GGAAAACAG
A CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAA
GATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCTT GTGAGATGAG
AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT GGGTAGGACA TTCAGAGGAG GGGGC
GGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT
TTGGGTAGGA CATTCAGAGG AGGGGGCGGG TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGG
AGGG GGCGGGTCGT GGTTGTGGGT TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA C
AACTTCAAG ATGGTAAAGG ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTG
AGA AGGAGGAAAA ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TA
CAATGAAA ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAAT
AG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC AGT
CATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT TTGGAGATA
G AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGG
TTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC AAAAGTATAT TTACTTGCTT
TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA TTTGAAATCT ATTTTTCCAT AAAAG
TATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTTTA
CTGATATACT TAGGAATTTT GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCA
ATTG TTGACTTAAA TACTGAGATA AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA T
TTGTTCACT TGGAGATCAA AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAA
AAT GTCTTAGGCC TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CA
GTAAGATA CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAA
AT CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA TGA
ACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT TCTCATGAA
G GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT CTAACAGAAT TCTC
TTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC
TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT CAGTTGCCCA TCCAAACTTG TTTAT
TGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA
TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATA
TGTA CCATGTACAT GAAGAAGCTA AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC C
TTGTAATTC TAAATGAATG TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGT
TAT TTAAAGAACA CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA AT
TTTAGGAG GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAA
AT TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC TAG
GATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC TTAATCAAA
T AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT AATACCTAAG CCTT
CCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA AAATACTTCT CGAAGCCGAG
CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT TATTATTTAT ATATGTATTT ATAAA
TATAT TTAAGATAAT TATAATATAC TATATTTATG GGAACCCCTT CATCCTCTGA GTGTGACCAG
GCATCCTCCA CAATAGCAGA CAGTGTTTTC TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCA
TTTT GGTCCAAGTT GTGCTTATCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT G
TAATCATAT AATAAATGTA CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTG
CCA TTAAACTTAC CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TA
AAATTAGA TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATG
TA ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA ACA
ATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT CTGACACAT
A GTTATTCATT GCCTTAATCA TTATTTTACT GCATGGTAAT TAGGGACAAA TGGTAAATGT TTAC
ATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT TTATATTTTT TTCTCCTCTT
TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA ATATTTCCGG GTTCACTTAA AGCTC
ATATT ACACATACAC AAAACATGTG TTCCCATCTT TATACAAACT CACACATACA GAGCTACATT
AAAAACAACT AATAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA CTTTGGGAGG-3' (フ
ラグメント番号 )(配列番号2510) 5'-ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCA
TTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA TGGCTTATT
A CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTC
CAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC
AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCC
CTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC
CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACT
GCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT C
CACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAA
AGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TT
GAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGAT
GG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGT
TCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAG
G CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAG
AGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT
ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGC
TAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC
CTTTTGTTGA GCCAGGCCTC TCTCACCTCT CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGG
CCAC ATTTGGTTCT AAGAAACCCT CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC T
ATTTATTTA TTTATTTGTT TGTTTGTTTT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGT
AGC AGTGTCTGTA AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TG
CTCTCTTT AAATCAAGTC CTTTAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAA
TA TTTATAAATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG-3' (フ
ラグメント番号 )(配列番号2511) 5'-AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGC
TCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG ATCCTGTGG
A GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTT TTAGCTATCT GCAGGCCAGA CACC
AAATTT CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCTTATCAA ATTCACAGGA AACTAACATG
TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC TAAAGATGGA GTTCTTGTGA CTGAC
TCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA TCAGAAGGCT GCTTGGAGAG CAAGTCCATG
AAATGCTCTT TTTCCCACAG TAGAACCTAT TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCAC
TCCC TTGGATAATG CAGAGCGAGC ACGATACCTG GCACATACTA ATTTGAATAA AATGCTGTCA A
ATTCCCATT CACCCATTCA AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCT
AGA CTTGGCTCAA AAAGATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT TCAACTCAGT GC
TATAAGAA GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTTGGG AGGCCGAG
GC GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT CTA
CTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC TGGGGAGGC
T GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA GATCGTGCCA CTGC
ACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC
CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC ACTGTTCATA ACCTGGACTC TCATT
CATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG CACTTTGCTG GTGTCTCGGT
TAAAGAGAAA CTGATAACTC TTGGTATTAC CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAA
ACAA TATTCCCACT TTTCAGAGTT CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA T
CTGGTTCAT CCATGAGATT GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCT
CCA GGGTTGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CA
AGAAAGGT CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGC
AC CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC CCA
TTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG AAAAGTATG
T GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA TACTAAATTT AAACATTCTT CTAA
CGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCACAACGA TTGTCAGGAA AACAATGCAT
ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG CTACTCCTTG CCCTTCCATG AACCA
GAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA GAAGCTTCCA CCAATACTCT TTTCCCCTTT
CCTTTAACTT GATTGTGAAA TCAGGTATTC AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTT
GAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC A
ACAGGCTGC TCTGGGATTC TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTAC
AAC TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TC
TCTCTCTT TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAA
TG CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT AAC
AGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC ATTGCTAGT
T GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT CACACATTCA TTCA
TTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA
CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA CACAGGTGTC TGAAGCAGCC ATGGC
AGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGGTC AGTGGAGACG CTGAGACCAG
TAACATGAGC AGGTCTCCTC TTTCAAGAGT AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCC
CTAA ATTGCCTCTT TCAGTGGCAA ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC A
TTACAAGTC CCTCCAGCCT TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCA
GAG GCAAATGGGG AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TT
GGAGGGAG AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCA
AC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC ATA
TCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT TTCTTATGA
A CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA TAATTGAGAC ATGT
CCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTTTGAAG CTGATGGCCC TAAACAGATG
AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCTC AAAGA
AGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT TGTTTTAGAA AGACTTTAAC CTCTTCCAGT
GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTTGGT CATCATATCA CCACAGTCAC TCACTA
ACGT TGGTGGTGGT GGCCACACTT GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC A
TAGTAGGAA GACAACCAAG TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTA
TGC CAATCACTTG AGTTAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CC
CTTTTGAG TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATA
AA CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT CAT
TTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG ATTCCAGCA
T CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG GGCAGCAAAT GGTC
ATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCCTGCTG TCCCTTCTGT TTTATATGAT
GCTCAGTAGC CTTCCTAGGT GCCCAGCCAT CAGCCTAGCT AGGTCAGTTG TGCAGGTTGG AGGCA
GCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG TGATAGCCTC CCCTAGCCTC ATAATCCAGT
CCTCAATCTT GTTAAAAACA TATTTCTTTA GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGC
TGTG GGAGGAGCCC ATTGGCTTGT CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT G
GCTCTGCTC CAGGCAGGAA ATTCTCTCCT GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAA
CTG TCTTTCAAGC CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AG
CTTCTCTG AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGC
CT ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT GAG
TGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCA
T TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAG
ATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACATTCTAG
TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA CCCTTAACCT CCTTGAGCTT CAGAG
AGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT GTTTTGTTTT GTTTTGTTTT GTTTTATGAG
ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCA
CCTC CTGAGTTCAA GCGATTCTCC TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC C
ACCACACCC AGCTAATTTT TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTT
TTG AAGTCCTGAC CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GA
GCCACCAC GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTC
CT CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG CTC
CCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT GGCGGCATC
C AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TCAGTTGTTG TGGC
CATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTTC CAGGAGAATG ACCTGAGCAC
CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA GCAGGCAGTA GATCTCCACT TGTGT
CCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG
AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAAC
TATT CTTAAAGAAG ATCTTGATGG CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC T
TTCACTTAC ATTGTCACCA GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTT
TAC CTAAGTAGCT CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TC
TAATAGTG TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCAT
CA GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA CGA
GGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT CTTCTTCGA
C ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCTC CGGG
ACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC
AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT CCCTGCCTGG CCTCCTGGCA GCTTG
CTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA ATTTAAGGCA AATGATCAAC ACAAGTGAAA
AAAAATATTA AAAAGGAATA TACAAACTTT GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAG
TGCA TTTGTTAACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT C
CACCCAAGT CTCTTGGGCA TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACAT
GGC CTAACTGCCT GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TA
ATGTGTCC ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTG
GT TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA AAG
TTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAA
G CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC CTCACTCAGG GGGA
AGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTTTGGAA TCGGGTAGTA AGAGTGATCC
CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA AAATGAGTGT CTCTCTTTGG AGCCA
CTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT CCCATGGGCT ACTCTCTGTT CCTGAAACAG
TTCTGGTGCC TGATTTCTGG CAGAAGTACA GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAG
TTGT TCCGCTCCTG TGGATGGGCA CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC C
TTCAGCATT TAAAATGTAG ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACC
CTC AGGCCTTTGA GGGGAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AA
GTTATCCT GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTA
TC CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC CCT
TCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAGAAGAAA GTAATGACAA AATACCTGT
G GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA TGATAAGCCC ACTC
TACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC CTCCTGCTAC CACTTATTCC
CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA GCTGGGAACA GGTCTATTTG ACAAG
TTTTG CATTAATGTA AATAAATTTA ACATAATTTT TAACTGCGTG CAACCTTCAA TCCTGCTGCA
GAAAATTAAA TCATTTTGCC GATGTTATTA TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATA
TTGT TAGGGCTGCT CTCATTTGAT AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT C
ACGTCCACT CCACTCCCAA AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTT
CCA AGTTGATGTC ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT AC
TTCAAGAA GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCC
TC AGCATTTGGC ACTAAGTTTT AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT TGG
GGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT CCTTTCTGG
C CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA AAATTCTTCT TTCT
CTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA TGGAAAAGCG ATTTGTCTTC
AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG CCCAGTTCCC CAACTGGTAC ATCAG
CACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG GAGGGACCAA AGGCGGCCAG GATATAACTG
ACTTCACCAT GCAATTTGTG TCTTCCTAAA GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGG
ACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC T
TTCCTGTTG TCTACACCAA TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCA
TCA GCCAGGACAG TCAGCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CT
CTCTCACC TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAA
AC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT GTT
TGTTTGT TTTGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGA
G CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGGACT GGTGTGCTCT CTTTAAATCA AGTC
CTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAAATGGG AATATTTATA AATGAGCAAA
TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTG
ATCAT TGACTGTCTG GATTGACACT GACAGTAAGC AAACAGGCTG TGAGAGTTCT TGGGACTAAG
CCCACTCCTC ATTGCTGAGT GCTGCAAGTA CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCC
TCAC CCATCCCCTT TATTTCGTTG TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC A
GCTGAAGCA CTGCAGGGAG TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCA
AAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GT
CCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGA
TA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGG
GATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT AATCCCAGC
A CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC AGCCTGGGCA ACAT
AGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT
GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG GATTGCTTGA GCCCAGAAGT TCAAG
ACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA C-3' (フラグメント番号 )(配列
番号2512) 5'-ACAAACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCA
ATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTTATT
A CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTC
CAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC
AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCC
CTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC
CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACT
GCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT C
CACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAA
AGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TT
GAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGAT
GG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGT
TCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAG
G CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAG
AGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT
ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGC
TAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC
TTTTGTTGAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCC
ACAT TTTGGTTCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC C
CTATTTATT TATTTATTTG TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGA
AGT AGCAGTGTCT GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GT
GTGCTCTC TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGG
GA ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT-3' (フ
ラグメント番号 )(配列番号2513) 5'-CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGA
CACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTTCGC
T TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCC
CTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA CCGTATATCC CTGTTTGTTT
GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCAAAGA TATGA
AACTA TCCATGAAGA ACAATATTAT CAATACACAG CAGTCTTTTG TAACCATGCC CAATGTGATT
GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGAT
GATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA G
TTATAAGTC ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCAT
TTT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AG
AAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGC
GA-3' (フラグメント番号 )(配列番号2514) 5'-ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA GAC
AGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT GGCCCACTC
C ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCT
TACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT CTGAAGAAGA GACGGTTGAG
TTTAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGGAAGA AATCA
TCAAG CCTAGGTCAG CACCTTTTAG CTTCCTGAGC AATGTGAAAT ACAACTTTAT GAGGATCATC
AAATACGAAT TCATCCTGAA TGACGCCCTC AATCAAAGTA TAATTCGAGC CAATGATCAG TACCTC
ACGG CTGCTGCATT ACATAATCTG GATGAAGCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT C
AAAGGATGA TGCTAAAATT ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCA
AGA TGAAGACCAA CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TG
AGACCAAC CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATC
CA AACTTGTTTA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATC
ACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT TGTGCAGTG
T TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT AGTCATTTGC TGAG
CATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT AAGAGTGGAA CCAACACTAA
CATATAATGT TGTTATTTAA AGAACACCCT ATATTTTGCA TAGTACCAAT CATTTTAATT ATTAT
TCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC TCTACCCATA
TTACAGATGG GCAAATTAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAA
GCCA CAGACCTAGG ATTTCATGAT TTCATTTCAA CTGTTTGCCT TCTGCTTTTA AGTTGCTGAT G
AACTCTTAA TCAAATAGCA TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA GGGAATA
ATA CCTAAGCCTT CCTGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT AC
TTCTCGAA GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTATT ATTTATAT
AT GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC CTC
TGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT TTGATTTCA
T TAATACAGGG CATTTTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGCATTCT AGTA
CTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG AGCCAGTAAT TGGTCCGATC
TTTGACTCTT TTGCCATTAA ACTTACCTGG GCATTCTTGT TTCATTCAAT TCCACCTGCA ATCAA
GTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTTG ACAACCATAG ACCACTGTTA TCAAAACTTT
CTTTTCTGGA ATGTAATCAA TGTTTCTTCT AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACA
TTAT TATCAACAAT AGTGATTGAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA G
GGAGTCATT TCATTGGCGT TTGAGTCAGC AAAGAAGTCA AG-3' (フラグメント番号 )(
配列番号2515) 5'-AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT GGC
CAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTTCCTC
C ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG CCCACTCCAT GAAG
GCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CTTACCTTCA
AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT GAAGAAGAGA CGGTTGAGTT TAAGC
CAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC
TAGGTCATCA CCTTTTAGCT TCCTGAGCAA TGTGAAATAC AACTTTATGA GGATCATCAA ATACGA
ATTC ATCCTGAATG ACGCCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT G
CTGCATTAC ATAATCTGGA TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATG
ATG CTAAAATTAC CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AA
GACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAAC
CT CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA CTT
GTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT CACTGACTT
T CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG TGCAGTGTTG ACAG
TTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG TCATTTGCTG AGCATGTACT
GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA GAGTGGAACC AACACTAACA TATAA
TGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA GTACCAATCA TTTTAATTAT TATTCTTCAT
AACAATTTTA GGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGAT
GGGC AAATTAAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA G
ACCTAGGAT TTCATGATTT CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTA
ATC AAATAGCATA AGTTTCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TA
AGCCTTCC TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAA
GC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT ATT
TATAAAT ATATTTAAGA TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT CTGAGTGTG
A CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT GATTTCATTA ATAC
AGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAAACTC TGCATTCTAG TACTTGGGAG
ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG CCAGTAATTG GTCCGATCTT TGACT
CTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT CATTCAATTC CACCTGCAAT CAAGTCCTAC
AAGCTAAAAT TAGATGAACT CAACTTTGAC AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCT
GGAA TGTAATCAAT GTTTCTTCTA GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT A
TCAACAATA GTGATTGATA GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG
-3' (フラグメント番号 )(配列番号2516) ヒトインターロイキン-1レセプター(IL-1 R)核酸およびアンチセンスオリゴヌ クレオチドフラグメント 5'-GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AAT
GTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC ACACACAGG
G GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGC
CTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC
TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCC
CAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA GGAGGACTCT GGCACCTACG TCTGCACTAC
TAGAAATGCT TCTTACTGTG ACAAAATGTC CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTT
CCTG CCGTTCATCT CATACCCGCA AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT G
ACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTT
TGG ATAAAGACAA TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TG
GCCCTGGA AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAAC
AT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTC
CCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT GTTTCTGGG
A ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCT
ACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA AAATAATGAG AACTACATTG
AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTC
CATAA TACCCTGAGT TTTCAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG
GGGCATTGTG CTGGCCCCAC TTTCACTGGC CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACG
GTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT C
AATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAA
A GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGG
GGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG
CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC TGGGA
TCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT
GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA AGAAGAATAT GAAAGTGTTA CTCAGA
CTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG A
AAAAATAAT TTTAGTGTCA TCTGCAAATG AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGA
ACA CAAAGGCACT ATAACTTGGT ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CT
CCAGGATT CATCAACACA AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATT
AC TATTGCGTGG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAG
AATGAGC CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGAC
G GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT TACA
GTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA AAGATAGGCT
CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG CATCCTACAC ATACT
TGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC TAGAGGAAAA CAAACCCACA
AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATTG
ATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG CTTACTGGAA GTGGAATGGG TCAGTAATTG A
TGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAG
TAC CCTCATCACA GTGCTTAATA TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CT
GTTTTGCC AAGAATACAC ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATT
TC CAGAAGCACA TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATC
TATAAAA TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATA
A AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTC
TACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC AGTGTGGATA
TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG AGGTCATTAA TGAAA
ACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA CATCAGGCTT CAGCTGGCTG
GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGTTCAGGA TGGAATTAAA GTTGTC
CTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA ATCGATTAAA TTCATTAAGC A
GAAACATGG GGCTATCCGC TGGTCAGGGG ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTT
CTG GAAGAATGTC AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT AC
TGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAG
TT GCCAAGAGTT CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTG
ACTTGCA GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3'
(フラグメントNO: )(配列番号2520) 5'-GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AAT
GTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC ACACACAGG
G GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGC
CTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC
TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCC
CAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA GGAGGACTCT GGCACCTACG TCTGCACTAC
TAGAAATGCT TCTTACTGTG ACAAAATGTC CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTT
CCTG CCGTTCATCT CATACCCGCA AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT G
ACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTT
TGG ATAAAGACAA TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TG
GCCCTGGA AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAAC
AT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTC
CCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT GTTTCTGGG
A ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCT
ACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA AAATAATGAG AACTACATTG
AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTC
CATAA TACCCTGAGT TTTCAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG
GGGCATTGTG CTGGCCCCAC TTTCACTGGC CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACG
GTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT C
AATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAA
A-3' (フラグメント番号 )(配列番号2518) 5'-GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTG
GGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTA
G CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC TGGG
ATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT
GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA AGAAGAATAT GAAAGTGTTA CTCAG
ACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG
AAAAAATAAT TTTAGTGTCA TCTGCAAATG AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATG
AACA CAAAGGCACT ATAACTTGGT ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC C
TCCAGGATT CATCAACACA AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACAT
TAC TATTGCGTGG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GA
GAATGAGC CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGA
CG GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT TAC
AGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA AAGATAGGC
T CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG CATCCTACAC ATAC
TTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC TAGAGGAAAA CAAACCCACA
AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATT
GATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG CTTACTGGAA GTGGAATGGG TCAGTAATTG
ATGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGA
GTAC CCTCATCACA GTGCTTAATA TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC C
TGTTTTGCC AAGAATACAC ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAAT
TTC CAGAAGCACA TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC AT
CTATAAAA TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAAT
AA AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGT
CTACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC AGTGTGGAT
A TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG AGGTCATTAA TGAA
AACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA CATCAGGCTT CAGCTGGCTG
GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGTTCAGGA TGGAATTAAA GTTGT
CCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA ATCGATTAAA TTCATTAAGC
AGAAACATGG GGCTATCCGC TGGTCAGGGG ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGT
TCTG GAAGAATGTC AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT A
CTGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAA
GTT GCCAAGAGTT CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CT
GACTTGCA GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3
' (フラグメント番号 )(配列番号2519) ヒトインターロイキン-8*フラグメントアンチセンスオリゴヌクレオチドフラ
グメント 5'-GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB GGB
BBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCB
BGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTGCTTG
T GTGCTCTGCT GTCTCTG TTC CTTCCGGTGG TTTCTTCCTG GCTCTTGTCC TTTCTCTTGG CCC
TTGGCCC-3' (フラグメント番号1834) (配列番号1847) 5'-G CTC CGG-3' (フラグメント番号1835) (配列番号1848) 5'-CBBGBBTBGC-3' (フラグメント番号1836) (配列番号1849) 5'-CBCBC BGTGBGGTGC-3' (フラグメント番号1837) (配列番号1850) 5'-BCCBBBGCBT CBBGBBTBGC-3' (フラグメント番号1838) (配列番号1851) 5'-GCCBBGBGBG CCBCGGCCBGC-3' (フラグメント番号1839) (配列番号1852) 5'-GTG CTC CGG TGG CTT TTT-3' (フラグメント番号1289)(配列番号1298) 5'-GCT TGT GTG CTC TGC TGT CTC TG-3' (フラグメント番号1290)(配列番号1299
) 5'-'TTC CTT CCG GTG GTT TCT TCC TGG CTC TTG TCC T-3' (フラグメント番号12
91)(配列番号1300) 5'-TTC TCT TGG CCC TTG GCC C-3' (フラグメント番号1292)(配列番号1301) 5'-GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB GGB
BBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCB
BGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTGCTTG
T-3' (フラグメント番号1840) (配列番号1853) ヒトIL-8レセプターアルファアンチセンスオリゴヌクレオチドフラグメント
5'-ACAGGGGCTG TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CA
CATCTGTG GATCTGTAAT ATTTGACATG TCCTCTTCAG TTTCAGCAAT GGTTTGATCT AACTGAAG
CA CCGGCCAGGB CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTTBGBTC BTC
BBBBTCC CBCBTCTGTG GBTCTGTBBT BTTTGBCBTG TCCTCTTCBG TTTCBGCBB TGGTTTGBTC
TBBCTGBBGC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC TGTTGTTGCG GCGCTCGGTT GGTGT
GGCCC CTGTGGTGCT TCGTTTCCCC CTCTTTCTCT TTGTTCGGGG GTTCTTGTGG CGGGCTGCTT
GTCTCGTTCC-3'(フラグメント番号1841)(配列番号1854) 5'-CBGGGGC-3' (フラグメント番号1842) (配列番号1855) 5'-GCBGGTGGC-3' (フラグメント番号1843) (配列番号1856) 5'-GCGGCGCTC-3' (フラグメント番号1844) (配列番号1857) 5'-TGGCTCGGTGCTTCTGCCCC (フラグメント番号1293)(配列番号1302) 5'-TGTTGTTGCGGCGCTC (フラグメント番号1294)(配列番号1303) 5'-GGTTGGTGTGGCCCCTG (フラグメント番号1295)(配列番号1304) 5'-TGGTGCTTCGTTTCC (フラグメント番号1296)(配列番号1305) 5'-CCCTCTTTCTCTTTGTTC (フラグメント番号1297)(配列番号1306) 5'-GGGGGTTCTTGTGGC (フラグメント番号1298)(配列番号1307) 5'-GGGCTGCTTGTCTCGTTCC (フラグメント番号1299)(配列番号1308) 5'-ACAGGGGCTG TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CA
CATCTGTG GATCTGTAAT ATTTGACATG TCCTCTTCAG TTTCAGCAAT GGTTTGATCT AACTGAAG
CA CCGGCCAGG-3' (フラグメント番号1845) (配列番号1858) 5'-B CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTTBGBTC BTCBBBBTCC C
BCBTCTGTG GBTCTGTBBT BTTTGBCBTG TCCTCTTCBG TTTCBGCBB TGGTTTGBTC TBBCTGBB
GC BCCGGCCBGG-3' (フラグメント番号1846) (配列番号1859) インターロイキン-11(IL-11)核酸およびアンチセンスオリゴヌクレオチドフラ グメント 5'-GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGC
AGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTG
T GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTG
TCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC TCGGGCCGAG CTGGACAGCA
CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAA
TTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT
GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCA
CGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC C
TGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCC
AGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GG
GCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTG
CT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA TTT
ATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT CCCCCTAGT
T AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC TTATTTATTT CAGG
AGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATTCT
TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TCTTCCCCAT CTAGGCCTGG GCAGG
AACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT GTTGGGGTGG GGACGGAGGG GAAAGGGAAG
CCTGGGTTTT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCA
TACA TATCC CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGG
GTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC A
GAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT CTCTCTG
GCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC TTCACTCTGT GT
GTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC CTCCTGCCTC CACCTCTC
CA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT TCCGTCCTCC TGCCTCCCCA TCT
CTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCTTGA GCCTGAGTG
T CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCA
CCCCCC CCTTTCCCTT TTCAACTTTT CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG
TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATG
TGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC
CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCA
GCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC G
GCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG GTTCATG
GGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CC
CGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCTTCG GAGACAGG
AG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGG
CGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGG
G ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGG
GACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA
GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGA
AAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG
GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCG
GGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC C
CCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTC
CGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AA
GGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC TTTTGGCTCC TTCCCCTG
CT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTTCTGGCCT GTGCCTCCCC CAC
CATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTG
C TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGC
CCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG
CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGA
GTCCA GGCCCCCAGC CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT
CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCT
TATC CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT G
TCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG GACAGCA
CCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AG
ACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCAC
TT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGG
GGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT TTTCCCTGCC AGAGGGACA
A ATTCCCAGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCA
CTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG
GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCC
AGGTG TGCTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC
GGGCAGGTGG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACC
GGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC A
CCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT GCAACAG
CCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GC
TCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGC
CC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA ACTTCAAATT CTCACCCAAG ACC
CTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATC
C TGAAGCCCAA AGCCTTGAGA ATTCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGAC
ATTGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC
GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGT
CTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA
GGCTGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATT
ACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA A
AGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGAC
ATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT GGGACCCTGG CT
GTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACAT
CG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAA
GCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGTTCTT GGGCCTAACT CCAAAGACC
C TGGATCTCAA ATTCCAACTT CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTG
AACCCA GAGACCCCAT CTCTAAGACT TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC
ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAAT
CCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA
GCATAGCAAG ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTGG AGACAGAGTC TCGCGC
TCTG TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC T
CAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC ACCCGGA
TAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG TCACAAACTC CT
GAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCT
GG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGG
CGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC TCCACAGAC
T TCACCCCCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAAC
CCCACA GCCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT
GCAGCCCCGA TTCAGCTGCA GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCT
GTGAC TCACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC
CGCCGGCGCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCC
TGGG GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT G
TGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA TTTCAGT
ACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG AGACAGTCCT TC
CGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA GGAGCAGGGG TGGGAGGC
AG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC CGGATTCTTG GGTCTCCAAG AAG
TCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT AGGCCTGGGC AGGAACATAT ATTATTTAT
T TAAGCAATTA CTTTTCATGT TGGGGTGGGG ACGGAGGGGA AAGGGAAGCC TGGGTTTTTG TACA
AAAATG TGAGAAACCT TTGTGAGACA GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG
GGCGATTTGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGA
CCTCC ATTCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA
CAGCTCTGTG GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGT
TTTT TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT G
CAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA TCACAGG
TGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT TTTAGTAGAG ACAGGGTTTC AC
CATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT GCCTCGGCCT CCCAAAGT
GC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT CTTCAATAAA TATTTAATGG AAG
GTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAAAGC TGCAAGGTCA AGATGGTTC
A TTATGGCTGT GTTCACCATA GCAAACTGGA AACAATCTAG ATATCCAACA GTGAGGGTTA AGCA
ACATGG TGCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC
TAAGGAGAGA GGCTTGCTTG GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCAC
GCCTG TAATCCTGGC ACTTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC
CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGC
AGGC TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA A
ACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG GAGAGAG
GTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT TCTGCCATGA CT
GTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA ATAACAGAAT ATCAGCCT
CC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAG GGC
TGTGCAC-3' (フラグメント番号 )(配列番号2523) 5'-GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGC
AGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTG
T GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTG
TCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC TCGGGCCGAG CTGGACAGCA
CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAA
TTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT
GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCA
CGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC C
TGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCC
AGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GG
GCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTG
CT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA TTT
ATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT CCCCCTAGT
T AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC TTATTTATTT CAGG
AGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATTCT
TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TCTTCCCCAT CTAGGCCTGG GCAGG
AACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT GTTGGGGTGG GGACGGAGGG GAAAGGGAAG
CCTGGGTTTT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCA
TACA TATCC-3' (フラグメント番号 )(配列番号2521) 5'-CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGGGTCT CCC
TGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCT
C CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT CTCTCTGGCT GCCT
CCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC TTCACTCTGT GTGTGTGTGT
GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC CTCCTGCCTC CACCTCTCCA GGCCC
CTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG
CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTGCTC
CGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC C
CTTTCCCTT TTCAACTTTT CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCC
TGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GG
CCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCG
TC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG CGG
GCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC GGCTCCCTG
C CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG GTTCATGGGG AGGG
TGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT
CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCTTCG GAGACAGGAG GCGGC
GGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA
GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAG
GGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG G
AGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGA
GCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GG
GAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGG
GC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG GGC
GGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCC
C CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAG
GTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC
CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC TTTTGGCTCC TTCCCCTGCT CCCAG
CCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTTCTGGCCT GTGCCTCCCC CACCATCCGC
GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGAC
GGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG G
CGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGA
CCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GG
CCCCCAGC CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCG
GG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC CTG
CCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCT
G GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCT
CCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AGACTGGGCT
GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGG
GGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG
AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCC
AGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA G
CTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGG
GAG GATGAGGGGC ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TG
CTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGT
GG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT GCT
GCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC ACCCCTGGC
C CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT GCAACAGCCC CGCT
CTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GCTCTGAGAC
CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGCCC TGAGA
CCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA ACTTCAAATT CTCACCCAAG ACCCTGAGAC
TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGC
CCAA AGCCTTGAGA ATTCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA A
ACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAA
GTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CT
AAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGG
CA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC TCC
AGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAA
A AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTAA
AGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT GGGACCCTGG CTGTACAAAC
CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAAC
CCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC
CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATC
TCAA ATTCCAACTT CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA G
AGACCCCAT CTCTAAGACT TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACC
TCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GG
CAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA GCATAGCA
AG ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTGG AGACAGAGTC TCGCGCTCTG TTG
CCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC TCAAGCGAT
T CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC ACCCGGATAA TTTT
TTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG TCACAAACTC CTGAGCTCAG
GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCTGG CTTCT
TAATT GTTCTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGGCGACTCT
AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCC
CCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA G
CCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCC
CGA TTCAGCTGCA GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TC
ACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCG
CC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG GGG
GCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT GTGACCCGG
G GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA TTTCAGTACT GGGG
GCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG AGACAGTCCT TCCGTGAGGC
CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA GGAGCAGGGG TGGGAGGCAG GTGGA
CTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC CGGATTCTTG GGTCTCCAAG AAGTCTGTCC
ACAGACTTCT GCCCTGGCTC TTCCCCATCT AGGCCTGGGC AGGAACATAT ATTATTTATT TAAGCA
ATTA CTTTTCATGT TGGGGTGGGG ACGGAGGGGA AAGGGAAGCC TGGGTTTTTG TACAAAAATG T
GAGAAACCT TTGTGAGACA GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATT
TGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC AT
TCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTG
TG GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGTTTTT TGA
GATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT GCAACCTCC
A CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA TCACAGGTGT GCAC
CACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG
CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT GCCTCGGCCT CCCAAAGTGC TGGGA
TTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT CTTCAATAAA TATTTAATGG AAGGTTCCAC
AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGG
CTGT GTTCACCATA GCAAACTGGA AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG T
GCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAG
AGA GGCTTGCTTG GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCACGCCTG TA
ATCCTGGC ACTTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC CGGCCTGC
GA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC TAC
AAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA AACAAAAAT
C CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGAT
TGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT TCTGCCATGA CTGTGTATTT
TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA ATAACAGAAT ATCAGCCTCC TCCTC
TCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAG GGCTGTGCAC-
3' (フラグメント番号 )(配列番号2522) ヒトGM-CSF核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGT
CCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG GGTGGCBGG
T CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GCGGTCCBGCCBTGGGTCTG GGGGC
TGGG CTGCBGGCTC CGGGCGGGCG GGTGCGGGCT GCGTGCTGGG GGCTGCCCCG CAGGCCCTGC G
GTCCBGCCB TGGGTCTGGG GGCTGGGCTG CBGGCTCCGG GCGGGCGGGT GCGGGCTGCG TGCTGGG
GGC TGCCCCGCAG GCCCTGC-3' (フラグメント番号1847) (配列番号1860) 5'-GBGCBGG BBG-3' (フラグメント番号1848) (配列番号1861) 5'-GCCBCBGCBGCBGC-3' (フラグメント番号1849) (配列番号1862) 5'-GGG TGC GGG C-3' (フラグメント番号1850) (配列番号1863) 5'-GGT CCB GCC BTG GGT CTG GG-3' (フラグメント番号1300)(配列番号1309) 5'-GGC TGG GCT GCB GGC TCC GG-3' (フラグメント番号1301)(配列番号1310) 5'-GCG GGC GGG TGC GGG CTG CGT GCT GGG-3' (フラグメント番号1302)(配列番
号1311) 5'-GGC TGC CCC GCA GGC CCT GC-3' (フラグメント番号1303)(配列番号1312) 5'-CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGT
CCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG GGTGGCBGG
T CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GC-3' (フラグメント番号185
1) (配列番号1864) ヒト腫瘍壊死因子αアンチセンスオリゴヌクレオチドフラグメント 5'-GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC CBC
GTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGGGCTGG TCCTCTGCT
G TCCTTGCTGG TGCTCBTGGT GTCCTTTCCG CCCTGGGGCC CCCCTGTCTT CTTGGGGCCT CTTC
CCTCTG GGGGCCGTCT CTCTCCCTCT CTTGCGTCTC TCTCTTTCTC TCTCTCTCTT CCCCTTTCCC
GCTCTTTCTG TCTCGGTGTC TGGTTTTCTC TCTCCGCTGG CTGCCTGTCT GGCCTGCGCT CTTGG
CCTGT GCTGTTCCTC CTCCGGTTCC TGTCCTCTCT GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG
GGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGC
GTCT GCTGGCGCTG GTCCTCTGCTGTC CTTGCTGGTG CTCBTGGTGT CCTTTCCGCC CTGGGGCCC
C CCTGTCTTCT TGGGGCCTCT TCCCTCTGGG GGCCGTCTC TCTCCCTCTC TTGCGTCTCT CTCTT
TCTCT CTCTCTCTTC CCCTTTCCCG CTCTTTCTGT CTCGGTGTCT GGTTTTCTCT CTCCGCTGGC
TGCCTGTCTG GCCTGCGCTC TTGGCCTGTG CTGTTCCTCC TCCGGTTCCT GTCCTCTCTG TCTGTC
GCCC CCTCTGGGGT CTCCCTCTGG CGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB G
TGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGC-3' (フラグメント番号1852)(配列番
号1865) 5'-GGGGCCCCCC-3' (フラグメント番号1853) (配列番号1866) 5'- GGG GGC CG TCT-3' (フラグメント番号1854) (配列番号1867) 5'-CCBGGGGBGB GBGGGGCTGG-3' (フラグメント番号1855) (配列番号1868) 5'-GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC CBC
GTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGG-3' (フラグメン
ト番号1304) (配列番号1313) 5'-GCT GGT CCT CTG CTG TCC TTG CTG GTG CTC BTG GTG TCC TTT CC GCC CTG GG
G CCC CCC TGT CTT CTT GGG G CCT CTT CCC TCT GGG GGC CG TCT CTC TCC CTC T
CT TGC GTC TCT C TCT TTC TCT CTC TCT CTT CCC C TTT CCC GCT CTT TCT GTC T
C GGT GTC TGG TTT TCT CTC TCC GCT GGC TGC CTG TCT GGC CTG CGC TCT T GGC
CTG TGC TGT TCC TCC TCC GGT TCC TGT CCT CTC TGT CTG TC GCC CCC TCT GGG G
TC TCC CTC TGG C GTG GTG GTC TTG TTG CTT GGG CTG GGC TCC GTG TCT C CBG T
GC TCB TGG TGT CC-3' (フラグメント番号1305) (配列番号1314) 5'-GCT GBG GGB GCG TCT GCT GGC GCT GGT CCT CTG CTG TCC TTG CTG GTG CTC B
TG GTG TCC TTT CC GCC CTG GGG CCC CCC TGT CTT CTT GGG G CCT CTT CCC TCT
GGG GGC CG TCT CTC TCC CTC TCT TGC GTC TCT C TCT TTC TCT CTC TCT CTT CCC
C TTT CCC GCT CTT TCT GTC TC GGT GTC TGG TTT TCT CTC TCC GCT GGC TGC CT
G TCT GGC CTG CGC TCT T GGC CTG TGC TGT TCC TCC TCC GGT TCC TGT CCT CTC
TGT CTG TC GCC CCC TCT GGG GTC TCC CTC TGG C GTG GTG GTC TTG TTG CTT GGG
CTG GGC TCC GTG TCT C CBG TGC TCB TGG TGT CC GCT GBG GGB GCG TCT GCT GG
C-3'(フラグメント番号1306)(配列番号1315) 5'-GCT GGT CCT CTG CTG TCC TTG CTG-3' (フラグメント番号1655) (配列番号16
64) 5'-GTG CTC BTG GTG TCC TTT CC-3' (フラグメント番号1656)(配列番号1665) 5'-GCC CTG GGG CCC CCC TGT CTT CTT GGG G-3' (フラグメント番号1657)(配列
番号1666) 5'-CCT CTT CCC TCT GGG GGC CG-3' (フラグメント番号1658)(配列番号1667) 5'-TCT CTC TCC CTC TCT TGC GTC TCT C-3' (フラグメント番号1659)(配列番号1
668) 5'-TCT TTC TCT CTC TCT CTT CCC C-3' (フラグメント番号1660)(配列番号1669)
5'-TTT CCC GCT CTT TCT GTC TC-3' (フラグメント番号1661)(配列番号1670) 5'-GGT GTC TGG TTT TCT CTC TCC-3' (フラグメント番号1662)(配列番号1671) 5'-GCT GGC TGC CTG TCT GGC CTG CGC TCT T-3' (フラグメント番号1663)(配列
番号1672) 5'-GGC CTG TGC TGT TCC TCC-3' (フラグメント番号1664)(配列番号1673) 5'-TCC GGT TCC TGT CCT CTC TGT CTG TC-3' (フラグメント番号1665)(配列番号
1674) 5'-GCC CCC TCT GGG GTC TCC CTC TGG C-3' (フラグメント番号1666)(配列番号1
675) 5'-GTG GTG GTC TTG TTG CTT-3' (フラグメント番号1667)(配列番号1676) 5'-GGG CTG GGC TCC GTG TCT C-3' (フラグメント番号1668)(配列番号1677) 5'-CBG TGC TCB TGG TGT CC-3' (フラグメント番号1669)(配列番号1678) 5'-GCT GBG GGB GCG TCT GCT GGC-3' (フラグメント番号1670)(配列番号1679) ヒトロイコトリエンC4シンターゼ核酸およびアンチセンスオリゴヌクレオチド フラグメント 5'-CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CC
TGCGCGCC GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBG
CCB GTBGBGCTBC CTCGTCCTTC BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CG
BGCTGGGC CCCGTCTGCT GCTCCTCGTG CCGCCTCGTC CTTCA TGG TA CCGTCGGTGT GGTGGC
CTCG GGTGGGCCGG TGGTGGGGCG CGCGCGCTCG CGTGGCTCCG GCTCTTCTTT CCCGGCTCCGT
CGGCCCGGGG GCCTTGGTCT CCCTCGTCCT TCBTGGTBCC G-3' (フラグメント番号1856)
(配列番号1869) 5'-GCB GCBGGBC-3' (フラグメント番号1857) (配列番号1870) 5'-CCCGGCTCCG-3' (フラグメント番号1858) (配列番号1871) 5'-CGGCCCGGGG GCC-3' (フラグメント番号1859) (配列番号1872) 5'-CB CGCGG-3' (フラグメント番号1860) (配列番号1873) 5'-GCC CCG TCT GCT GCT CCT CGT GCC G-3' (フラグメント番号1307)(配列番号1
316) 5'-CCT CGT CCT TCA TGG TAC CGT CGG TGT GGT GGC-3' (フラグメント番号1308)
(配列番号1317) 5'-CTC GGG TGG GCC GGT GGT G-3' (フラグメント番号1309)(配列番号1318) 5'-GGG CGC GCG CGC TCG CGT-3' (フラグメント番号1310)(配列番号1319) 5'-GGC TCC GGC TCT TCT TTC CCG GCT CCG TCG GCC CGG GGG CCT TGG TCT C-3'(
フラグメント番号1311)(配列番号1320) 5'-CCT CGT CCT TCB TGG TBC CG-3' (フラグメント番号1312)(配列番号1321) 5'-CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CC
TGCGCGCC GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBG
CCB GTBGBGCTBC CTCGTCCTTC BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CG
BGCTGG-3' (フラグメント番号1861) (配列番号1874) ヒトエンドセリン-1核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG TGGGTTTCTC CCCGCCGTTC TCBCCCBCCG CGC
TGBGCTC BGCGCCTBBG BCTGCTGTTT CTGGBGCTCC TTGGCBBGCC BCBBBCBGCB GBGBGBBBB
T CBTGBGCBBB TBBTCCBTTC TGBBBBBBBG GGBTCBBBBB CCTCCCGTTC CCCGTTCGCC TGGC
GCGCGC TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TTCTCCGGTC TGTTGCCTTT GTGGGCTTCT
TGTCTTTTTG GCTGTTCTTT TCCTGCTTGG CGTCTTTTCC TTTCTTTGTG CTCGGTTGTG GGTCC
GCTGG TCCTTTGCCC TGTGTGTTTC TGCTGCCCGT TCGCCTGGCG CGCGCTGCGG GTTCCTCGTG
GGTTTCTCCC CGCCGTTCTC CGGTCTGTTG CCTTTGTGGG CTTCTTGTCT TTTTGGCTGT TCTTTT
CCTG CTTGGCGTCT TTTCCTTTCT TTGTGCTCGG TTGTGGGTCC GCTGGTCCTT TGCCCTGTGT G
TTTCTGCTG-3' (フラグメント番号1862) (配列番号1875) 5'-CCGGCGGBG CCGCCBGGGT GGBC-3' (フラグメント番号1863) (配列番号1876) 5'-CCGCCBGGG-3' (フラグメント番号1864) (配列番号1877) 5'-GGCGCGCGC-3' (フラグメント番号1865) (配列番号1878) 5'-GTGGGTCCGC-3' (フラグメント番号1866) (配列番号1879) 5'-CCCGTTCGCCTGGCGC-3' (フラグメント番号1313)(配列番号1322) 5'-GCGCTGCGGGTTCCTC-3' (フラグメント番号1314)(配列番号1323) 5'-GTGGGTTTCTCCCCGCCGTTCTC-3' (フラグメント番号1315)(配列番号1324) 5'-CGGTCTGTTGCCTTTGTGGG -3' (フラグメント番号1316)(配列番号1325) 5'-CTTCTTGTCTTTTTGGCT-3' (フラグメント番号1317)(配列番号1326) 5'-GTTCTTTTCCTGCTTGGC-3' (フラグメント番号1318)(配列番号1327) 5'-GTCTTTTCCTTTCTT-3' (フラグメント番号1319)(配列番号1328) 5'-TGTGCTCGGTTGTGGGTC-3' (フラグメント番号1320)(配列番号1329) 5'-CGCTGGTCCTTTGCC-3' (フラグメント番号1321)(配列番号1330) 5'-CTGTGTGTTTCTGCTG-3' (フラグメント番号1322)(配列番号1331) 5'-CCCGTTCGCCTGGCGC-3' (フラグメント番号1323)(配列番号1332) 5'-GCGCTGCGGGTTCCTC-3' (フラグメント番号1324)(配列番号1333) 5'-GTGGGTTTCTCCCCGCCGTTCTC-3' (フラグメント番号1325(配列番号1334) 5'-CGGTCTGTTGCCTTTGTGGG-3' (フラグメント番号1326)(配列番号1335) 5'-CTTCTTGTCTTTTTGGCT-3' (フラグメント番号1327)(配列番号1336) 5'-GTTCTTTTCCTGCTTGGC-3' (フラグメント番号1328)(配列番号1337) 5'-GTCTTTTCCTTTCTT-3' (フラグメント番号1329)(配列番号1338) 5'-TGTGCTCGGTTGTGGGTC-3' (フラグメント番号1330)(配列番号1339) 5'-CGCTGGTCCTTTGCC-3' (フラグメント番号1331)(配列番号1340) 5'-CTGTGTGTTTCTGCTG-3' (フラグメント番号1332)(配列番号1341) エンドセリンレセプターET-B核酸およびアンチセンスオリゴヌクレオチドフラ グメント 5'-GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACC
AGCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG
TCCGGTGGCC GCCGCGCC CTGTCGGGCG GGBBGCCTCT CTCCTCTCCC CBGBTCCGCG BCBGGCC
GCB GGCBBGBBCC BGCGCBBCCB GGGCGCGTCC GCBCBGBCTT GGBGGCGGCT GCBTGCTGCT BC
CTGCTCGGGCG GGBBGCCTCCG GTGGCCGCCG CGCGTCCGGT GGCCGCCGCG CCTCTCTCCT CTCC
CCGTGG CCCTGTCGGG CGGGTCCTGC CGTCCTGTCT CCTTTTCTTT TGCTGTCTTG TCTTCCCGTC TCTGCTTT-3' (フラグメント番号1867) (配列番号1880) 5'-CGGGCG GGBBGCC-3' (フラグメント番号1868) (配列番号1881) 5'-CGGGCGGG-3' (フラグメント番号1869) (配列番号1882) 5'-CCGCBCBGBC-3' (フラグメント番号1870) (配列番号1883) 5'-GCGTCCGGTGGCCGCCGC-3' (フラグメント番号1333)(配列番号1342) 5'-GCCTCTCTCCTCTCCCC-3' (フラグメント番号1334)(配列番号1343) 5'-GTGGCCCTGTCGGGCGGG-3' (フラグメント番号1335)(配列番号1344) 5'-TCCTGCCGTCCTGTCTCCTTT-3' (フラグメント番号1336)(配列番号1345) 5'-TCTTTTGCTGTCTTGT-3' (フラグメント番号1337)(配列番号1346) 5'-CTTCCCGTCTCTGCTTT-3' (フラグメント番号1338)(配列番号1347) 5'-GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACC
AGCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG
TCCGGTGGCC GCCGC-3' (フラグメント番号1871) (配列番号1884) 5'-GCCCTGTCGG GCGGGBBGCC TCTCTCCTCT CCCCBGBTCC GCGBCBGGCC GCBGGCBBGB BCC
BGCGCB BCCBGGGCGC GTCCGCBCBG BCTTGGBGGC GGCTGCBTGC TGCTBCCTGC TCCBGBBGCG
TCCGGTGGCC GCCGC-3' (フラグメント番号1872) (配列番号1885) エンドセリンETAレセプター核酸およびアンチセンスオリゴヌクレオチドフラ
グメント 5'-GTCTGTCCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGGG CTTCCCCGGC TTCGGGTGGC CGG
TGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGGGCTGCC GGGTCCGCG
C GGCGCCTGGG CCCTTGTGCT GCTTTTTGCT TGTTCCGTTC TGGCTGCTCC GGTCTGTGTT GTGG
TTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG GCCCTTTGGG GCCTTGGCTT
CTGGCTCGTC TGTCCTCCCC GTCTCCTCCC ACTGCTTCT CCCGGGGGCT TCCCCGGCTT CGGGTG
GCCG GTGTCCCGGG CTCCGGCGCG GCGGCGGCTT CGGCTGCGGG TGGGTGGCGC GGGCTGCCGG G
TCCGCGCGG CGCCTGGGCC CTTGTGCTGC TTTTTGCTTG TTCCGTTCTG GCTGCTCCGG TCTGTGT
TGT GGTTGTTTTG TTTCTTCTTG GGTGTGGGCC TTGCGGTTTT GGCTGTGGGC CCTTTGGGGC CT
TGGCTTCT GGCTCCAT CCACATGATT GCTTAGATTT GTGCTGTATC TCTCAGGATT ATCACTGATT
ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC AAAGGGTTTC CATCTTGAGG CAAAT
TTGAG GACBTCCBC BTGBTTGCTT BGBTTTGTGC TGTBTCTCTC BGGBTTBTCB CTGBTTBCBC B
TCCBBCCBG TGCCBGCCBB BBGGBTGCCC TGBGGCBBBG GGTTTCCBTC TTGBGGCBBB TTTGBGG
B-3' (フラグメント番号1873) (配列番号1886) 5'-GBGGCBBBGGG-3' (フラグメント番号1874) (配列番号1887) 5'-GCCBGCCBB BBGGB-3' (フラグメント番号1875) (配列番号1888) 5'-CGCCTGGGCC C-3' (フラグメント番号1876) (配列番号1889) 5'-GTCTGTCCTCCCCGTCTCCTCCC-3' (フラグメント番号1339)(配列番号1348) 5'-ACTGCTTCTCCCGGGG-3' (フラグメント番号1340)(配列番号1349) 5'-GCTTCCCCGGCTTC-3' (フラグメント番号1341)(配列番号1350) 5'-GGGTGGCCGGTGTCCCGGGCTCCGGCGCGGCGGC-3' (フラグメント番号1342)(配列番号
1351) 5'-GGCTTCGGCTGC-3' (フラグメント番号1343)(配列番号1352) 5'-GGGTGGGTGGCGCGG-3' (フラグメント番号1344)(配列番号1353) 5'-GCTGCCGGGTCCGCGCGGCGCCTGGGCC-3' (フラグメント番号1345)(配列番号1354)
5'-CTTGTGCTGCTTTT-3' (フラグメント番号1346(配列番号1355) 5'-TGCTTGTTCCGTTC-3' (フラグメント番号1347)(配列番号1356) 5'-TGGCTGCTCCGGTCTGTGTTGTGGTTGTTTTG-3' (フラグメント番号1348)(配列番号13
57) 5'-TTTCTTCTTGGGTGTGGG-3' (フラグメント番号1349)(配列番号1358) 5'-CCTTGCGGTTTTGG-3' (フラグメント番号1350)(配列番号1359) 5'-CTGTGGGCCCTTTG-3' (フラグメント番号1351)(配列番号1360) 5'-GGGCCTTGGCTTCTGGCTC-3' (フラグメント番号1352)(配列番号1361) 5'-CATCCACATG ATTGCTTAGA TTTGTGCTGT ATCTCTCAGG ATTATCACTG ATTACACATC CAA
CCAGTGC CAGCCAAAAG GATGCCCTGA GGCAAAGGGT TTCCATCTTG AGGCAAATTT GAGGA-3'
(フラグメント番号1353) (配列番号1362) 5'-CBTCCBCBTG BTTGCTTBGB TTTGTGCTGT BTCTCTCBGG BTTBTCBCTG BTTBCBCBTC CBB
CCBGTGC CBGCCBBBBG GBTGCCCTGB GGCBBBGGGT TTCCBTCTTG BGGCBBBTTT GBGGB-3'
(フラグメント番号1354)(配列番号1363) エンドセリンレセプターA核酸およびアンチセンスオリゴヌクレオチドフラグ
メント 5'-GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATC
AGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGT
G GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGG
CTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT
GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACC
AGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC
TATGTGGTCA TTGATCTCCC TATCAATGTA TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTG
GCGT ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA C
CTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGG
ATT CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CC
TGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCT
CA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCT
ATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACA
G AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAA
ACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG
AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCAT
GGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG
TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTC
TGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA C
AACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT GAATTCG
GGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AA
GATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAA
TC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAG
AGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGC
A CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCT
TGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA
TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGT
CATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT
TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCA
ACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT T
GGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATT
CCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT AT
GCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTT
CT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGA
ACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAA
A AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATA
TTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC
ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTT
TGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA
GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACC
ACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG T
ACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGA
TCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CT
GGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGT
GT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGA
AGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTC
T GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACT
TTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA
TGTCATTTGG TGCCAGTATC CCGAATTC GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAA
GTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TT
TTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAA
TC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AAC
CCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTA
C TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGG
AATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA
GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCT
GCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT
TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACA
GAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT T
GTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCC
TTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TT
CTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGC
GA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCC
TCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTG
C TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGAC
AAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC
ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCA
GTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA
CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACA
GCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT C
ACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCA
AGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CG
TACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAG
CT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAG
AGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCA
T GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCC
AAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC-3
' (フラグメント番号 ) (配列番号3014) 5'-GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AAT
TTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAAT
C AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTC
GTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG
GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACT
GTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA
CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTAT
CTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT C
ACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCA
CCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TT
CAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATC
CT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAA
AACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCT
C TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTG
AGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG
AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTA
AGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT
CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGC
TCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC C
AGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATC
AAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CA
CTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCT
CT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAA
GGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACAT
A TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAAT
GAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA
TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGA
TTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT
TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC-3' (フラグメント番号 ) (配
列番号2482) 5'-GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AAT
TTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAAT
C AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTC
GTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG
GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACT
GTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA
CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTAT
CTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT C
ACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCA
CCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TT
CAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATC
CT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAA
AACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCT
C TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTG
AGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG
AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTA
AGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT
CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGC
TCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC C
AGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATC
AAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CA
CTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCT
CT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAA
GGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACAT
A TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAAT
GAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA
TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGA
TTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT
TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC-3'(フラグメント番号 ) (配列
番号2470) 5'-GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATC
AGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGT
G GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGG
CTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT
GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACC
AGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC
TATGTGGTCA TTGATCTCCC TATCAATGTA TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTG
GCGT ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA C
CTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGG
ATT CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CC
TGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCT
CA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCT
ATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACA
G AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAA
ACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG
AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCAT
GGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG
TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTC
TGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA C
AACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT-3' (フ
ラグメント番号 ) (配列番号2469) サブスタンス(Substance)Pアンチセンス核酸およびオリゴヌクレオチドアンチ センスオリゴヌクレオチドフラグメント 5'-CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTC
CTCCTTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT CCTBTTTC
TT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTTCBTGT TGG
BTTTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCBC GTGGTCGCT
C CGCGTTTCTC TGGTTCCTCC GGTCCCGCGG GGTGCTGTCT GGTCGCTGTC GTGGCTTGGG TCTC
CGGGCG GTTTCCTTCC TTTTCCGC-3' (フラグメント番号1877) (配列番号1890) 5'-CTCC GGGCGB-3' (フラグメント番号1878) (配列番号1891) 5'-GGCCBCGBGG-3' (フラグメント番号1879) (配列番号1892) 5'-GGGTCTCCGGGCG-3' (フラグメント番号1880) (配列番号1893) 5'-GGG TCTCCGGGCG G-3' (フラグメント番号1881) (配列番号1894) 5'-CGTGGTCGCTCCGC-3' (フラグメント番号1355)(配列番号1364) 5'-GTTTCTCTGGTTCCTCCG-3' (フラグメント番号1356)(配列番号1365) 5'-GTCCCGCGGGGTGCTG-3' (フラグメント番号1357)(配列番号1366) 5'-TCTGGTCGCTGTCGT-3' (フラグメント番号1358)(配列番号1367) 5'-GGCTTGGGTCTCCGGGCG-3' (フラグメント番号1359)(配列番号1368) 5'-GTTTCCTTCCTTTTCCGC-3' (フラグメント番号1360)(配列番号1369) 5'-CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTC
CTCCTTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT CCTBTTTC
TT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTTCBTGT TGG
BTTTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCB-3' (フラグ
メント番号1882) (配列番号1895) サブスタンスPレセプター核酸およびアンチセンスオリゴヌクレオチドフラグ
メント 5'-GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGT
BGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG BGGTGTTBG
T GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTTT CGBBGCTBGG CGGT
BBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG TCGTGGCGCC TGGGGCTCBG
GGTCCGGGC TAAGATGATC CACATCACTA CCACGTTGCC CACCACAGAG GTCACCACAA TGACCG
TGTA GGCAGCTGCC CAAAGGACAA TTTGCCAGGC TGGTTGCACG AACTGATTGG GTTCCGAGGT G
TTAGTGGAG ATGTTTGGGG AGAGGTCTGA GTCCACCGGG AGGACGTTAT CCATTTCGAA GCTAGGC
GGT AAAGCCCTAC TATCTGTACA CAACCCCCCT CTGCAGCAGA GTCCTGTCGT GGCGCCTGGG GC
TCAGGGTC CGTCCTGTCG TGGCGCCTGG GGCTCTTCTT TTGTGGGCTC TTTGGTGGCT GTGGCTGT
GG TCTCTGTGGT TGCTGCCCTG GGTCTGGGGG TGTGGCCTTG GGGCCGTCCT CTGGCTCCTC CTC
GTGGGCC CCC-3' (フラグメント番号1883) (配列番号1896) 5'-GGGBGGBCG-3' (フラグメント番号1884) (配列番号1897) 5'-GGGTC CG-3' (フラグメント番号1885) (配列番号1898) 5-'GGGCC CCC-3' (フラグメント番号1886) (配列番号1899) 5'-GTCCTGTCGTGGCGCCTGGGGCTC-3' (フラグメント番号1361)(配列番号1370) 5'-TTCTTTTGTGGGCT-3' (フラグメント番号1362)(配列番号1371) 5'-CTTTGGTGGCTGTGGCTG-3' (フラグメント番号1363)(配列番号1372) 5'-TGGTCTCTGTGGTTG-3' (フラグメント番号1364)(配列番号1373) 5'-CTGCCCTGGGTCTGG-3' (フラグメント番号1365)(配列番号1374) 5'-GGGTGTGGCCTTGGGGCCGTCCTCTGGCTCCTCCTCGTGGGCCCCC (フラグメント番号1366)
(配列番号1375) 5'-GGGCTAAGAT GATCCACATC ACTACCACGT TGCCCACCAC AGAGGTCACC ACAATGACCG TGT
AGGCAGC TGCCCAAAGG ACAATTTGCC AGGCTGGTTG CACGAACTGA TTGGGTTCCG AGGTGTTAG
T GGAGATGTTT GGGGAGAGGT CTGAGTCCAC CGGGAGGACG TTATCCATTTC GAAGCTAGGC GGT
AAAGCCC TACTATCTGTA CACAACCCCC CTCTGCAGCA GAGTCCTGTC GTGGCGCCTG GGGCTCAG
GGTCC-3'(フラグメント番号1367)(配列番号1376) 5'-GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGT
BGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG BGGTGTTBG
T GGBGBTGTTT GGGGBGBGGTC TGBGTCCBCC GGGBGGBCGT TBTCCBTTTC GBBGCTBGGC GGT
BBBGCCC TBCTBTCTGTB CBCBBCCCCC CTCTGCBGCB GBGTCCTGTC GTGGCGCCTG GGGCTCBG
GG TCC-3' (フラグメント番号1368) (配列番号1377) キマーゼ(Chymase)アンチセンス核酸およびオリゴヌクレオチドアンチセンス
オリゴヌクレオチドフラグメント 5'-GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG BGC
BCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC CTGBGCBBB
T GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG CGTT
TTCTTC TCTCGCTGGT TTTCCTTTCC TGGCAGTGGG TGGGGGTGGG GGTGGGGTGG CTTCCTTGTT
CCTGGGGGTG TCCTCTTGCT CTGGGCTTTT CTCCCCTTTT CCTTCCTGTC TGTTTTCCTG GGGCT
CTCCT CTGTCTCTGT GTCCTTGCCC TGGCCCTCTT CCCTCTCCTG TCTCCTGTCC CTGTGTTCCG
CCCGTCTTCC CTCTCCTGAC CTCCTTTTCC TCCGCTGGGT GGGGCCCTGC CTGTTCTCTG CTCCCTGGCT TGGGGT
TTCT TCTGTGTGTC TTCTTCCTCT GTTGGCTGGC TTTCTCCTTC TTTTGTCTTC CTGGGTGCCC C
TTCTTCCTT TCTTGGGTCC TTGGTGCTTG GGCTGGG TCCCAGTTAA TACATAATCA ATATGCAATT
TATTAATACA TCTCTCCATG TCCACTCCCC CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCC
TCCTT ACCTTCCCTA GAGGCCAACT CATTTTCTTT GAAAAACCTG GCATTTCCCA GAAAAAAAAG
TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA TTTGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGG
AAAG AAGCACTATT GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT G
GACACATGC TGTTGATACC ACCTGCCTCA TGAGTCTCAC ATAATTTGCC CTTTCACACT ATCTACC
CCA TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG AA
TCTCCTTG CAACCAAGAA TGACTAGACC AATGAGACAC CCTTTAAGGC CCCAGCACAA TATAGAAA
TC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT CTAGAATACA ACT
AGAGTAT AGTTCCTTTC AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGA
A GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATTA
AACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGAAT AGTTGTTGCC TTATCAACCT CCCCCACAGC
CCACACAGAA AAGATAAAAT CATCATGGCT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGG
CCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC
CATCCACATA AAGAGCTTTG CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTA
ATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG C
AAAATGCTT TTTAGGTTTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATC
TTC CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCATT CTCCTGGATA CA
CTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TATTGTGTTA GGAGTGAA
GG CAAGAGTATC GTAAAATAAA TCAAATTTGA AATGAATTCT CTTAAATTGC TTTATAGATG TTT
AATGTAA GCCAGCAGCT ATTAAACGAT AAACCTTAAA TTCGAGAAAA ACTTGGTCAT TCAGAAACT
A TAGAAACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT GAGCTCCAGC CTGCTTCAGG AAAA
TCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC CACTGCACTA CTGCTCAGTA TGAGCCCATG
CCATCAGCTG TCCCTGACCC ACAGGAGTTC TTTAGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGT
GTTTT ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA TGCTCAATCA AGAAAGACAC
AGTCATTACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACAT
GCAA AGCATGAAAT AACCAAATTC CATAACAGAT GTTAATCTGT AATGTGTTTA GGAGAATTTA G
AGGAAGTAT AAGATTTATT CTTTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT CAATTAT
CCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTTATTAA GA
ACCAATCA TGTGGCATTT CACATTGAGC ATCATATTTA ATTCTGAAAA AAATCCTTGT ACTGTATC
AT TCTTCATATT TTATGGATGC AGTAACTAAG GCTGAGAACT TTAAAATTTT TCCTAAGTTC AGA
CACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC TGCAGAGCAA ACTGCATGC
C TTAAATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT TTGGAAACTC AGAGAAGGAA TGAT
CCCTCT GCATTATAGT TACTAAGGAA TCATTGCCAT TATTTAAATG CCAGTGCTTC TACATCAGGC
CCAAATTTTC TGTCCTACTA ACTGTGAATC AAGACTTGAT TCAACCTCTA CTTGAGTATC TGCCG
CAATG AGAAATCACT TACCTCCACT AACCACACAT TTATTTTATA ACAACAGATT GTTAGTAAGT
CCTTTCTTAT ACATACTCAA CAGCTGCTTC CCAAGATGCT GTAGGATTAT GTCTAGAGTC AAACTA
GCCA GAAGCAATGT CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTGTTT G
GCCCAAACA TTCTAGGCAG CACTGGATAT CTGAATCATC AATTATTTCC ACAAACACTG ACCCCTC
TAC CAGTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA GCTCCCTCAT GTTACTCCCT TC
TAAGTCAA ATTGTACACC CCTTTATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAG
AA CTGGGAATGG ACGTTTGTGG ATTCTACCTT AGTAAGGCAA AGTTATCATT GGGAATTCCT CTA
ATACAGG AAGGGTGTTC CAGAGACATT AAGGAGCCAT ATAAATGGAA AATGTCCACT ACAATCCAT
C ACTTGGTTGC CCCACATCAA CATTCATTCT TTTGCCACAC TTAAAGTTTC CAAGAACAAA AATT
ATCCCA CTGAACATAA TCTTTACTAT CTTTTATATA AAGGAAAATT AGACTTGACT CAGCAGAACT
GAAATAACCC AGCTCTAACA GTTACTGCTT TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTG
CTCCA ACAATAGTTT GGTCACATTT TCAATTTGAT ATTCTCTAGT CTCCCAACTT GATAACTGTA
CCCTAAACCA TAAAGTTCAC TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGA
GAAA AAGGAAATCT CTTAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC A
GATAGTGCA GTCCTCGTTT CTGAAATTGG TCCCCTGACT GGGGCTATAC CTATTCCATT TCCTCAC
CCT CAGCCAGGCA GGTGGAGCAA AAACTTAAGT CTTGGTGGAT CTGAATCTTG ATGCTGTGGA GC
TGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAATTTCT AATTATATCA GTGAAAGCAA ACAGCTTT
GA TTTGTTTAAG CCTCTGATTT TTTGGTCTAA CTGATGTAAG ACCACAAGGA CAAGAGTTCT CCA
GCTCCGG ATTCTCTTCT GTTCTGTTAA TGGTGAAATG CCCGAGAGAA GAGTTGCCAA CTTTGGCAA
A TAAAAAATAC AGGATTCCAG TTAAATTCAA ATTTAGATAA ACAACAATTT TTTAGTATTA GTGT
GTCCCA TTCAATATTT GGACATACTT AACTAAAAAA TGATTTGTTG TTCATCTGAA ATACAAATTT
AACTGGGCAT TCTGAATATT CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACT
TAAGA AGACCAGATT TGAAAAGACA TTACGGATGT GTTTAAATGT CTTATTCTAG AGAGAGTTAG
AGCTGTAGGT AGAACTTGGG AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAA
GGAG TGGATCACTC TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATTTGGGAA A
GGCACTTAT ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCTTATAAA TCTCCAAGAG AAATGAC
AGT CCACCATGTG GACTGCTTTC TGTAAGTCCA GGGAAAATAA AAGCTATGTG CTTGAAACCC AC
TTCTGATA TTATAAGGTG TGTGATCTTT GTCATGTTAA TGGGTCTGAG TATCAATTCT ACAATTGT
AA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TTGATTCTTA ATGCAACAGT AGG
AAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTTTACTTCC CCTGCACATT GGCAGGACT
C TATTCCTCTA TTTCTCTCTA GTGCTAGAGC AGAAAGGGAC CTTGATTTGA TATCAGGAAA ATCT
ATTTCT GAACCATAAG CTATGATAGC TGATTTAAAA AATTGACTAT CATGACATGA TAATGATCAT
AATGGTAATA CATATTGATA GGGTTGCCGT GAAAGTAATA ATATATCTAA GAGTTGTGAC AATAT
ATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATTCC AATCCCAATT GCTCTTTGCA TAAAGTTCTG
TCCTAGGGTC TGTTCTTTTC CCACATCTAC CCTCCTTGGA TCTCTCTTCT GTCTTTTTCA TGTGGT
TCAG AGGAGGAGAG AGATCCAGGT CAATGTTTTT CAAATTACAA GGAATTATCA TTTAAATGGG G
AAGAAGCTC AAGTTTTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGA
AGA CACTGCACAT GGTTAAGATA AAGATTGTTT CCTGAAACCT TTAATTTGTG CTTACATACT CA
CACATACA TATGTGCATG CACTGGGACT CTGCAATATG CATTTCTGAC TATGGAACAT AGCCATAA
AA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG AAAGAAAAAC ATG
GTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA GGGTACATCT GAGAAGCCA
G CACTTGGGAG TTCAGGGCTC AAGTTCCTTT CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CTTC
CGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTTCCTG TGGTTACCAG
CCTTGCCCCT CTCTTGCCTT CTGGGAGTTA TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTG
CTCAG GCAGCCTCTC TGGGAAGATG CTGCTTCTTC CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT
CCAGAGCTGA AGCTGGTGAG TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAAC
AAAG ATGTTTAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC C
ACAGAGGAA ATTTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTA
CAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GG
AAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCTTC TGAGCATCAG GGCTACCC
AT TACTTTGTGA CTTTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAA
CCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAG
T CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATTTCACCT GGGAGGTTAT GGGT
GGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA
TTCCAGGGAA GCCTAGCTCA GCTTTAACCC AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCC
GTGTT CAAACCCTGG GGTGCTCTGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT
TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGT
TTCC TTATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG T
CTATTTATC TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGAC
TGA AGAGGGGGTC CTGGGTCTTG TCAACTTTCA GGAGAGGGAA GACTTTGGGC TGAAAGACTT TA
GTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA AAAGGAGG
TC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC TCAAGACACA CGG
CTCACTT TTCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG CCTTTTCAAG AACACTGGC
T CTAGTTCTCA GGGTCCTGAA CCCATCATTT TATGGGAGCA GAGAACAGGT CTACATAAGA CCCC
CACTTT CCCGTTTTAA CTGATATCTC CTGCTTCAGG GGCTGGCCCT CATGCAGGGT TCCCTGAATT
AGGAAGTGTG AACCCTGTCC CCTGAGTCCT CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGT
CGTAG AAATTGTGTC TGTTTCCTGA GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC
ACAAGTGGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTT
TTCT CAGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTTCCTTCCT T
CTTCCTCAC AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACA
TGG CAGAAGCTTG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC CA
CGATATCA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCTTTCCAC TTCCCATTCT CCTAAGCT
TC TCCTTCAGGT CCTCATTGCC CTGAATTTTT CTTAGGACTT GGCTATAACA TGAAGCTACT CAC
CCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG ACTGACAGTC CTTCATTCC
C TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAA
TTCAAC TTTGTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG
CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTT
CAGAG ACTTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA
AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAG
GAGA TGGGGTCAGC AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC C
GTGGTCCAA GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGG
AGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AG
CTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGA
GG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTT
CTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTC
T TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGAT
CCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG
TTCTACCCTT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAAC
TTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC
TTCTCCTGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA ATCATCGGGG GCACAGAATC C
AAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTT
TGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTCT AT
AACAGTCA CCCTTGGAGC CCATAACATA ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTAT
AA AGCAATTCCG TCATCCAAAA TATAACACTT CTACTCTTCA CCACGATATC ATGTTACTAA AGT
TGAAGGA GAAAGCCAGC CTGACCCTGG CTGTGGGGAC ACTCCCCTTC CCATCACAAT TCAACTTTG
T CCCACCTGGG AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCA
GACACT CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACTTT
GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC ATTTAAGGGA GACTC
TGGGG GCCCTCTTCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG TCGGATGCAA
AGCCCCCTGC TGTCTTCACC CGAATCTCCC ATTACCGGCC CTGGATCAAC CAGATCCTGC AGGCAA
ATTA A-3' (フラグメント番号1887) (配列番号3015) 5'-ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTA
ACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCT
G CTCATTGTGC AGGAAGGTCT ATAACAGTCA CCCTTGGAGC CCATAACATA ACAGAGGAAG AAGA
CACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA TATAACACTT CTACTCTTCA
CCACGATATC ATGTTACTAA AGTTGAAGGA GAAAGCCAGC CTGACCCTGG CTGTGGGGAC ACTCC
CCTTC CCATCACAAT TCAACTTTGT CCCACCTGGG AGAATGTGCC GGGTGGCTGG CTGGGGAAGA
ACAGGTGTGT TGAAGCCGGG CTCAGACACT CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAG
GCCT GCAGCCACTT CAGAGACTTT GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA C
AAAATCTGC ATTTAAGGGA GACTCTGGGG GCCCTCTTCT GTGTGCTGGG GTGGCCCAGG GCATCGT
ATC CTATGGACGG TCGGATGCAA AGCCCCCTGC TGTCTTCACC CGAATCTCCC ATTACCGGCC CT
GGATCAAC CAGATCCTGC AGGCAAATTA A-3'(フラグメント番号)(配列番号2468) 5'-TCCCAGTTAA TACATAATCA ATATGCAATT TATTAATACA TCTCTCCATG TCCACTCCCC CTG
TATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT CATTTTCTT
T GAAAAACCTG GCATTTCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA TTTG
CTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG AAGCACTATT GAAAAATCCC TAAACGCACC
CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC TGTTGATACC ACCTGCCTCA TGAGT
CTCAC ATAATTTGCC CTTTCACACT ATCTACCCCA TCAGCCTTAC CAAAACCATA CCTGCATCCT
GGGCAGCATC TGCCCTTCAA GAGACTAAGG AATCTCCTTG CAACCAAGAA TGACTAGACC AATGAG
ACAC CCTTTAAGGC CCCAGCACAA TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA T
CAAGCCATT GCAGGACCAT CTAGAATACA ACTAGAGTAT AGTTCCTTTC AATCCAGGAA CTATACT
CTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CA
CCAGCTCC ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGA
AT AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT ACA
GTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGA
G CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTTG CCCAAACTTA TGAT
AAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG
AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATGCTT TTTAGGTTTG TGCTGAAGAG CCTGG
AAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC CTCCTGCCCC AACACTGGGA TAATCTCCAA
GGATCTCTCC ATATCTCATT CTCCTGGATA CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTA
ATTC AAAAGTGAGC TATTGTGTTA GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAATTTGA A
ATGAATTCT CTTAAATTGC TTTATAGATG TTTAATGTAA GCCAGCAGCT ATTAAACGAT AAACCTT
AAA TTCGAGAAAA ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AA
CACAGAGT GAGCTCCAGC CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGC
TC CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC TTT
AGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGTGTTTT ATACCTGCCA ACTCGAGGGT TAAAACAAG
T TGCATAGAAA TGCTCAATCA AGAAAGACAC AGTCATTACT CAGAGAATAA TAAACAGCCT GGCA
GCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT AACCAAATTC CATAACAGAT
GTTAATCTGT AATGTGTTTA GGAGAATTTA GAGGAAGTAT AAGATTTATT CTTTCATCAA AAAAA
TTATA GCCAATGAGG ATATATCTAT CAATTATCCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA
ACACAAAGGA ATAAAACCAA CGTTTATTAA GAACCAATCA TGTGGCATTT CACATTGAGC ATCATA
TTTA ATTCTGAAAA AAATCCTTGT ACTGTATCAT TCTTCATATT TTATGGATGC AGTAACTAAG G
CTGAGAACT TTAAAATTTT TCCTAAGTTC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACT
CAC CCCATCTAAC TGCAGAGCAA ACTGCATGCC TTAAATGTCA AAGTGAATAC TAGCACAGTT AA
TACAATGT TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATTATAGT TACTAAGGAA TCATTGCC
AT TATTTAAATG CCAGTGCTTC TACATCAGGC CCAAATTTTC TGTCCTACTA ACTGTGAATC AAG
ACTTGAT TCAACCTCTA CTTGAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT AACCACACA
T TTATTTTATA ACAACAGATT GTTAGTAAGT CCTTTCTTAT ACATACTCAA CAGCTGCTTC CCAA
GATGCT GTAGGATTAT GTCTAGAGTC AAACTAGCCA GAAGCAATGT CCAAAATACA CCATAACACT
GTGCAGCAAA GGTCCTACTA CCACTTGTTT GGCCCAAACA TTCTAGGCAG CACTGGATAT CTGAA
TCATC AATTATTTCC ACAAACACTG ACCCCTCTAC CAGTCACCCT CACTAGAAGA ATTAATTCCA
CATGATAATA GCTCCCTCAT GTTACTCCCT TCTAAGTCAA ATTGTACACC CCTTTATCTG ATTAAC
AGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA CTGGGAATGG ACGTTTGTGG ATTCTACCTT A
GTAAGGCAA AGTTATCATT GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACATT AAGGAGC
CAT ATAAATGGAA AATGTCCACT ACAATCCATC ACTTGGTTGC CCCACATCAA CATTCATTCT TT
TGCCACAC TTAAAGTTTC CAAGAACAAA AATTATCCCA CTGAACATAA TCTTTACTAT CTTTTATA
TA AAGGAAAATT AGACTTGACT CAGCAGAACT GAAATAACCC AGCTCTAACA GTTACTGCTT TTA
ACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGTTT GGTCACATTT TCAATTTGA
T ATTCTCTAGT CTCCCAACTT GATAACTGTA CCCTAAACCA TAAAGTTCAC TACCAACATG CTAT
ATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT CTTAAAATAC ACAGGTATAC
ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTT CTGAAATTGG TCCCC
TGACT GGGGCTATAC CTATTCCATT TCCTCACCCT CAGCCAGGCA GGTGGAGCAA AAACTTAAGT
CTTGGTGGAT CTGAATCTTG ATGCTGTGGA GCTGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAAT
TTCT AATTATATCA GTGAAAGCAA ACAGCTTTGA TTTGTTTAAG CCTCTGATTT TTTGGTCTAA C
TGATGTAAG ACCACAAGGA CAAGAGTTCT CCAGCTCCGG ATTCTCTTCT GTTCTGTTAA TGGTGAA
ATG CCCGAGAGAA GAGTTGCCAA CTTTGGCAAA TAAAAAATAC AGGATTCCAG TTAAATTCAA AT
TTAGATAA ACAACAATTT TTTAGTATTA GTGTGTCCCA TTCAATATTT GGACATACTT AACTAAAA
AA TGATTTGTTG TTCATCTGAA ATACAAATTT AACTGGGCAT TCTGAATATT CTCTGGCAAC CCC
CGAGAGA GTGAAGAAAG TGGTACAAGG ACACTTAAGA AGACCAGATT TGAAAAGACA TTACGGATG
T GTTTAAATGT CTTATTCTAG AGAGAGTTAG AGCTGTAGGT AGAACTTGGG AAATTAAGTT AAAA
GCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC TGGTCACAAG CCCAACCTGA
GACCAAGGGC ATAGTGAGAT GATTTGGGAA AGGCACTTAT ACACTACTCA TCCCCGTCTT TGAAC
TAAAT GCCTTATAAA TCTCCAAGAG AAATGACAGT CCACCATGTG GACTGCTTTC TGTAAGTCCA
GGGAAAATAA AAGCTATGTG CTTGAAACCC ACTTCTGATA TTATAAGGTG TGTGATCTTT GTCATG
TTAA TGGGTCTGAG TATCAATTCT ACAATTGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT T
GTGGAAAGC TTGATTCTTA ATGCAACAGT AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTA
CAT CTTTACTTCC CCTGCACATT GGCAGGACTC TATTCCTCTA TTTCTCTCTA GTGCTAGAGC AG
AAAGGGAC CTTGATTTGA TATCAGGAAA ATCTATTTCT GAACCATAAG CTATGATAGC TGATTTAA
AA AATTGACTAT CATGACATGA TAATGATCAT AATGGTAATA CATATTGATA GGGTTGCCGT GAA
AGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATTC
C AATCCCAATT GCTCTTTGCA TAAAGTTCTG TCCTAGGGTC TGTTCTTTTC CCACATCTAC CCTC
CTTGGA TCTCTCTTCT GTCTTTTTCA TGTGGTTCAG AGGAGGAGAG AGATCCAGGT CAATGTTTTT
CAAATTACAA GGAATTATCA TTTAAATGGG GAAGAAGCTC AAGTTTTGAC GTGTAGTGGA ATTGG
AGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA CACTGCACAT GGTTAAGATA AAGATTGTTT
CCTGAAACCT TTAATTTGTG CTTACATACT CACACATACA TATGTGCATG CACTGGGACT CTGCAA
TATG CATTTCTGAC TATGGAACAT AGCCATAAAA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT C
ACAAGCTGC CCTAATTGGG AAAGAAAAAC ATGGTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAG
TCA CCATAGTTGA GGGTACATCT GAGAAGCCAG CACTTGGGAG TTCAGGGCTC AAGTTCCTTT CT
AGAAAAAC ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGA
AA ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTGCCCCT CTCTTGCCTT CTGGGAGTTA TAA
AACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGGAAGATG CTGCTTCTT
C CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG TATCAGGGTT CTTC
CCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGTTTAGTC TGAAATAGCT GACTCCTAAA
CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA ATTTCCACTT GGGATGTGTG CCACC
CCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC
ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATG
TCCT CTTAATCTTC TGAGCATCAG GGCTACCCAT TACTTTGTGA CTTTCTCACT CTGTGACCAT G
CTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAG
AGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GC
AAGAATGA GATTTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGG
GA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC AAT
TTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT TCCAGGGGA
G ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAA
CTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCTG
CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTTATC TCCAAATGGG AGATGAACAA CCAGA
GTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA AGAGGGGGTC CTGGGTCTTG TCAACTTTCA
GGAGAGGGAA GACTTTGGGC TGAAAGACTT TAGTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCA
CTGA GCTAAGCTCC CTTCGGAGGA AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC A
CCCCTCACC CCTACCCAAC TCAAGACACA CGGCTCACTT TTCAGGGCCC CACCCAGTCT CAGGGCC
ACT TCCTCTATGG CCTTTTCAAG AACACTGGCT CTAGTTCTCA GGGTCCTGAA CCCATCATTT TA
TGGGAGCA GAGAACAGGT CTACATAAGA CCCCCACTTT CCCGTTTTAA CTGATATCTC CTGCTTCA
GG GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT CCC
TGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AAATTGTGTC TGTTTCCTGA GAAAGCTCT
T TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG GAGATGGGTA GAGT
CCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTTTTCT CAGAATGAGC TCACCTCAGA AGAAACCCCA
AGCCATCACT GTCGCCTCCT TTTCCTTCCT TCTTCCTCAC AGCAGGTCTA TAACAGTCAC CCTTG
GAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTTG AGGTTATAAA GCAATTCCGT
CATCCAAAAT ATAACACTTC TACTCTTCAC CACGATATCA TGTTACTAAA GGTGACAACA CCTCTC
TTCT CCCTTTCCAC TTCCCATTCT CCTAAGCTTC TCCTTCAGGT CCTCATTGCC CTGAATTTTT C
TTAGGACTT GGCTATAACA TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGA
GCC CATTTCGAGG ACTGACAGTC CTTCATTCCC TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CC
TGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC TTTGTCCCAC CTGGGAGAAT GTGCCGGG
TG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTG
AGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTTGACCA CAATCTTCAG CTGTGTGTG
G GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAAC
TCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC AGGTTGTCAG TCAGGTGACA
GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA GACAGCCTCT GACCATCCAT TCCAG
TCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA
GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTG
TGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC C
TCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCT
ATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TC
AACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGAC
CT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT GGTTCCCTCA GCCACAACCC TAA
GCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAG
T CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT GATTCCCAGC CCAA
GCACCA AGGA-3' (フラグメント番号) (配列番号2467) 5'-GGBGCBCBBG-3' (フラグメント番号1888) (配列番号1901) 5'-GBBGCBGC-3' (フラグメント番号1889) (配列番号1902) 5'-GGGGCBBGG CG-3' (フラグメント番号1890) (配列番号1903) 5'-CGTTTTCTTCTCTC-3' (フラグメント番号1369)(配列番号1378) 5'-GCTGGTTTTCCTTTCC-3' (フラグメント番号1370)(配列番号1379) 5'-TGGCAGTGGGTGGGGGTGGGGGTGGGGTGGC-3' (フラグメント番号1371)(配列番号138
0) 5'-TTCCTTGTTCCTGGGGGTGTCCT-3' (フラグメント番号1372)(配列番号1381) 5'-CTTGCTCTGGGCTTTTCT-3' (フラグメント番号1373)(配列番号1382) 5'-CCCCTTTTCCTTCC-3' (フラグメント番号1374)(配列番号1383) [ 5'-TGTCTGTTTTCCTGGGG-3' (フラグメント番号1375)(配列番号1384) 5'-CTCTCCTCTGTCTCTGTGT-3' (フラグメント番号1376)(配列番号1385) 5'-CCTTGCCCTGGCCC-3' (フラグメント番号1377)(配列番号1386) 5'-TCTTCCCTCTCCTGTCTCCTGT-3' (フラグメント番号1378)(配列番号1387) 5'-CCCTGTGTTCCGCCC-3' (フラグメント番号1379)(配列番号1388) 5'-GTCTTCCCTCTCCTG-3' (フラグメント番号1380)(配列番号1389) 5'-ACCTCCTTTTCCTCCG-3' (フラグメント番号1381)(配列番号1390) 5'-CTGGGTGGGGCCCTG-3' (フラグメント番号1382)(配列番号1391) 5'-CCTGTTCTCTGCTCCC-3' (フラグメント番号1383)(配列番号1392) 5'-TGGCTTGGGGTTTCTTCTG-3' (フラグメント番号1384)(配列番号1393) 5'-TGTGTCTTCTTCCTCTGTT-3' (フラグメント番号1385)(配列番号1394) 5'-GGCTGGCTTTCTCCTTC-3' (フラグメント番号1386)(配列番号1395) 5'-TTTTGTCTTCCTGGG-3' (フラグメント番号1387)(配列番号1396) [1397)] 5'-TGCCCCTTCTTCCTTTCTTGGG-3' (フラグメント番号1388)(配列番号1397) 5'-TCCTTGGTGCTTGGGCTGGG-3' (フラグメント番号1389)(配列番号1398) 5'-GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG BGC
BCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC CTGBGCBBB
T GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG-3' (
フラグメント番号1891) (配列番号1904) 内皮酸化窒素シンターゼ核酸およびアンチセンスオリゴヌクレオチドフラグメ ント 5'-GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT GGG
GGGCCGG GGTGGCTGGG CCCTGCTTGC CGCACGACCC CGGGCCGACC CGAGGCTCGG GGGGCTGTG
T TCTGGCGCTG GTGGGCTTGG GCCCCTCTGG GGGCTGGGTT TCCTGCTGCG CCTGGGCGCT GGCG
TCTTGG GGTGCGGGGC CGGGGGGCCG GGGGGCCGCT GTTCGTGGGC CTGGGGGTGC CTGTGGCTGC
CGGTTGCCCC GGTTGGTGGC GCCGTCCTGC TGCCGGTCGT TGGCTGGGTC CCCCCGCCCG TTTCC
TGGGG TCCGCGTGGG GTGCTCCGGT TCCTCGTGCC GCTGCTGCCT TGTCTTTCCG GCCGTGGCGG
CGTGGTGGTC CGCCCCCCCT GGCCTTCTGC TCGGGGTCTG GCTGGTTGCC GGTGCCCTTG GCGGCG
GTCT TCTTCCTGGT GGCTCTGGGC CCGGCCGGTC TCGGGCGTCT CGTGTTCGCT CTTGTGCTGT T
CCGGCCGCT CCTTCCTCTT CCGCCGCCGC CGCTCCCCGC CCGCTCGTCG CCCTGGCCCG GCCTCCT
CCT GGCCGCTGTC TCGGGCGGCG GCCTTGGCGC TCCGTTTGGG GCTGCCTCTG GCGCTTCCGG CC
CTCGGCCT GGGCGCTCTC TTCCGCCTGT GCTGGTGGCC CTCGTGGGCC CCTCCTGGCC TCCGGTGT
CC TGTGGTCCCC CGGCTGGTGG CCGGGCCGGT TGGGCGGGCG TGGGCGCCGG CGGGTCCTCC GGG
CTGCCCT TCTCCGCCGG GGGTCCCGCG CTCCTGCTGT TCCCTGGGCT CTTCTGCCTC TCTCCTGGG
T GGGTGCTGGG TGCCGGGGTC TCCGGGCTTG CCCCGCGCTG CTGGGCGTTC TGCGGTCTTG GGGT
TGTCTG TGGCCCCGCT CGTGTCGCCC TCCGTCGCCC GTCGCCGGCC TCGTCCCCTC CTGGGTGCGC
GGCGGGCTGG TCCTGGCGTT TTGCTCCTTC CTGGGCGTCT TGGGGTGCBG GGCCCBTCCT GCTGC
GCCTG GGCGCTGCTG TGCGTCCGTC TGCTGGGGGG CCGGGGTGGC TGGGCCCTGC TTGCCGCACG
ACCCCGGGCC GACCCGAGGC TCGGGGGGCT GTGTTCTGGC GCTGGTGGGC TTGGGCCCCT CTGGGG
GCTG GGTTTCCTGC TGCGCCTGGG CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC C
GCTGTTCGT GGGCCTGGGG GTGCCTGTGG CTGCCGGTTG CCCCGGTTGG TGGCGCCGTC CTGCTGC
CGG TCGTTGGCTG GGTCCCCCCG CCCGTTTCCT GGGGTCCGCG TGGGGTGCTC CGGTTCCTCG TG
CCGCTGCT GCCTTGTCTT TCCGGCCGTG GCGGCGTGGT GGTCCGCCCC CCCTGGCCTT CTGCTCGG
GG TCTGGCTGGT TGCCGGTGCC CTTGGCGGCG GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC GGT
CTCGGGC GTCTCGTGTT CGCTCTTGTG CTGTTCCGGC CGCTCCTTCC TCTTCCGCCG CCGCCGCTC
C CCGCCCGCTC GTCGCCCTGG CCCGGCCTCC TCCTGGCCGC TGTCTCGGGC GGCGGCCTTG GCGC
TCCGTT TGGGGCTGCC TCTGGCGCTT CCGGCCCTCG GCCTGGGCGC TCTCTTCCGC CTGTGCTGGT
GGCCCTCGTG GGCCCCTCCT GGCCTCCGGT GTCCTGTGGT CCCCCGGCTG GTGGCCGGGC CGGTT
GGGCG GGCGTGGGCG CCGGCGGGTC CTCCGGGCTG CCCTTCTCCG CCGGGGGTCC CGCGCTCCTG
CTGTTCCCTG GGCTCTTCTG CCTCTCTCCT GGGTGGGTGC TGGGTGCCGG GGTCTCCGGG CTTGCC
CCGC GCTGCTGGGC GTTCTGCGGT CTTGGGGTTG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC G
CCCGTCGCC GGCCTCGTCC CCTCCTGGGT GCGCGGCGGG CTGGTCCTGG CGTTTTGCTC CTTCCTG
G-3' (フラグメント番号1892) (配列番号1905) 5'-GCGGGGCCG-3' (フラグメント番号1893) (配列番号1906) 5'-CGGGGGGC-3' (フラグメント番号1894) (配列番号1907) 5'-GCGCGGCGGGC-3' (フラグメント番号1895) (配列番号1908) 5'-CTGTGCGTCCGTCTGCTGG (フラグメント番号1390)(配列番号1399) GGGGCCGGGGTGGCTGGGCCCTGCTTGCCGC (フラグメント番号1391)(配列番号1400) ACGACCCCGGGCCGACCCGAG (フラグメント番号1392)(配列番号1401) GCTCGGGGGGCTGTGTTCTGGCGCTGGTGGG (フラグメント番号1393)(配列番号1402) CTTGGGCCCCTCTGGGGGCTGGGTT (フラグメント番号1394)(配列番号1403) TCCTGCTGCGCCTGGGCGCTG (フラグメント番号1395)(配列番号1404) GCGTCTTGGGGTGC (フラグメント番号1396)(配列番号1405) GGGGCCGGGGGGCCGGGGG (フラグメント番号1397)(配列番号1406) GCCGCTGTTCGTGGGCCTGGG (フラグメント番号1398)(配列番号1407) GGTGCCTGTGGCTGCC (フラグメント番号1399)(配列番号1408) GGTTGCCCCGGTTGGTGGC (フラグメント番号1400)(配列番号1409) GCCGTCCTGCTGCCGGT (フラグメント番号1401)(配列番号1410) CGTTGGCTGGGTCCCCCCGC (フラグメント番号1402)(配列番号1411) CCGTTTCCTGGGGTCC (フラグメント番号1403)(配列番号1412) GCGTGGGGTGCTCC (フラグメント番号1404)(配列番号1413) GGTTCCTCGTGCCG (フラグメント番号1405)(配列番号1414) CTGCTGCCTTGTCTTTCC (フラグメント番号1406)(配列番号1415) GGCCGTGGCGGCGTGGTGGTCC (フラグメント番号1407)(配列番号1416) GCCCCCCCTGGCCTTCTGCTC (フラグメント番号1408)(配列番号1417) GGGGTCTGGCTGGT (フラグメント番号1409)(配列番号1418) TGCCGGTGCCCTTGGCGGC (フラグメント番号1410)(配列番号1419) GGTCTTCTTCCTGGTG (フラグメント番号1411)(配列番号1420) GCTCTGGGCCCGGCCGGTCTCGG (フラグメント番号1412)(配列番号1421) GCGTCTCGTGTTCG (フラグメント番号1413)(配列番号1422) CTCTTGTGCTGTTCCGGCCG (フラグメント番号1414)(配列番号1423) CTCCTTCCTCTTCCGCCGCC (フラグメント番号1415)(配列番号1424) GCCGCTCCCCGCCC (フラグメント番号1416)(配列番号1425) GCTCGTCGCCCTGGCCC (フラグメント番号1417)(配列番号1426) GGCCTCCTCCTGGCCGC (フラグメント番号1418)(配列番号1427) TGTCTCGGGCGGCGGCCTTGGC (フラグメント番号1419)(配列番号1428) GCTCCGTTTGGGGCTG (フラグメント番号1420)(配列番号1429) CCTCTGGCGCTTCC (フラグメント番号1421)(配列番号1430) GGCCCTCGGCCTGGGCGCTC (フラグメント番号1422)(配列番号1431) TCTTCCGCCTGTGC (フラグメント番号1423)(配列番号1432) TGGTGGCCCTCGTGG (フラグメント番号1424)(配列番号1433) GCCCCTCCTGGCCTCCGGTGTCC (フラグメント番号1425)(配列番号1434) TGTGGTCCCCCGGCTGGT (フラグメント番号1426)(配列番号1435) GGCCGGGCCGGTTGGGCGGGC (フラグメント番号1427)(配列番号1436) GTGGGCGCCGGCGGGTCCTCC (フラグメント番号1428)(配列番号1437) GGGCTGCCCTTCTCC (フラグメント番号1429)(配列番号1438) GCCGGGGGTCCCGC (フラグメント番号1430)(配列番号1439) GCTCCTGCTGTTCCCTGGGCTCTTCTGCC (フラグメント番号1431)(配列番号1440) TCTCTCCTGGGTGGGTGCTGGGTGCCG (フラグメント番号1432)(配列番号1441) GGGTCTCCGGGCTTG (フラグメント番号1433)(配列番号1442) CCCCGCGCTGCTGGGCGTTCTGC (フラグメント番号1434)(配列番号1443) GGTCTTGGGGTTGTC (フラグメント番号1435)(配列番号1444) TGTGGCCCCGCTCG (フラグメント番号1436)(配列番号1445) TGTCGCCCTCCGTCGCC (フラグメント番号1437)(配列番号1446) CGTCGCCGGCCTCGTCC (フラグメント番号1438)(配列番号1447) CCTCCTGGGTGCGC (フラグメント番号1439)(配列番号1448) GGCGGGCTGGTCCT (フラグメント番号1440)(配列番号1449) GGCGTTTTGCTCCTTCCTGG (フラグメント番号1441)(配列番号1450) 5'-GCGTCTTGGGGTGCBGGGCCCBTCCTGCTGCGCCTGGGCGCTG-3'(フラグメント番号1896)
(配列番号1909) 誘導的酸化窒素シンターゼ核酸およびアンチセンスオリゴヌクレオチドフラグ メント 5'-CTGCCCCBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT TCT
GCTGCTT GCTGCTTCTT TCCCGTCTCC CTTCTTTCCC GTCTCCTTTT TGCCTCTTTG GGTTCCTGT
T GTTTCTGGCC TGCTTGGTGG CGGCTTGTGC GTTTCCTCTC TCTTCTCTTG GGTCTCCGCT TCTC
GTCCTG CCTTTTCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC CTCCTGCCCT GTGCTGTTTG
CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG GCTGGTTGCC TGGGCCTGTC TGGTG
GGGTG TGGGGCCGCT GGGTTGGGGG TGTGGTGGGC TCTTCTGTGG CCTGTGGGGC TGTTGGTGTC
TCTGTGGGCG TGTGCTGGGT CTTGGGGCTT CCTCCCTTGT GCTGGGTGCG GCCTCCCCGC CCCCCT
TCTG GGCCGGTGGC CTGGCTCCTT GTGGGCGCTT CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG T
GGCTGCTGG GCTGC CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA G
GCCGGGCAT TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTG
AGC TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AA
ATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGAT
CG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGT
GACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATA
A GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT TATAAGGGAA GGAATTTAAT CCTA
CCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA
GGCCTCTCTG TGCCAATAGC CTTCCTTCCT TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAG
GCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG
TGTTCCATAC TGTCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGA
TGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG C
CATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATG
AAC TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GA
TGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACA
CA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAA
ACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACTTTG
T AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTTTAAAAT CTCT
CGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC
TTCCTGGTTT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C CAT
ATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAA
C CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGTTC GAGA
CCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT
GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGG
CAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA
TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTT
CATG TAAGAAGTGA TCATTTCCAT TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA A
GCTTACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAAT
AGC CTTCCTTCCT TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TG
GCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATA
TT CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCA
GAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAAT
A AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACT
TGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG
TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCC
CTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGGATGGC
ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTG
AGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA G
GGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTC
CTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C-3' (フラグメント番号 )(配列番号3016) 5'-CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAG
TTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTG
C AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGT
AAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA AATTCCACCA GTATGCAATG
AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCCAGTCCA GTGAC
ACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG
AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGC
ATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA A
GGGATTTTA ACTTGCAGGT CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGA
GGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CA
ATATTACG GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAA
GG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC AGG
CCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT TCGATGCCC
G CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC GTTACTCCAC CAAC
AATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG ATGGCAAGCA CGACTTCCGG
GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGCATCAGA GGGGA
CCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG TACGGCCGCT
TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTG
ACCT TGTGCTTGAG GTGGCCATGG AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA G
TGGTACGCC CTGCCTGCAG TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGC
CCC TTCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TA
CAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAA
AG ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA CCA
TCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC GGTCCCGTG
G GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA TCACCCCCGT GTTT
CACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC AGGTAGAGGC CTGGAAAACC
CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGATTCCATT GAAAGTCTTG GTCAA
AGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA GTCACCATCC
TCTTTGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTG
CCTT CAACCCCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT G
CTGTTGGTG GTGACCAGTA CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAA
TCG CTCTTCATGC TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AG
CATGTACC CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTC
TC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT GGG
CCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA TTCAGATCC
C CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG TGCAGGACTC ACAG
CCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TGTTCACCAT GAGGCTCAAA
TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAACTCTCC TGTGA
GGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACCTTGGGGT TTGCCCAGGC AACCAGCCGG
CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGG
AGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG C
CAGGCCCTC ACCTACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCC
CAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AG
CAAGTGGA AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGT
GT CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT CCT
CCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA CCGGAGATG
G CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGCCCCAAGA CCCA
GTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA TCCTTGCATC
CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT TCTGGCAGCA ACGGCTCCAT GACTC
CCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTTTGG GTGCCGCCGC CCAGATGAGG
ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAG
CCTA TTCCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC C
AGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATG
GCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CA
GGTCGAGG ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGT
AT TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CGC
TCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA GCTCTGCAT
T ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTCAAGTCTT ATTT
CCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA GTAGCACCCT GGATTGATCG
GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG AGACAAAATC TTAAATGCCA GGCCT
GGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT GCACCACTTC AAGTGACCAC CAGGAGGTGC
TATCGCACCA CTGTGTATTT AACTGCCTTG TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTA
ACAC CCAGTCTGTT CCCCATGGCC ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT A
CATGAATTG CATTTTACTT TAATC GAATTCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC A
GTAACATGG GCAACTTGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGC
TGG GCCTTGGGCT GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CA
GCATCCCT ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAG
GG GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG CGC
CCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT TCCACGGAA
A CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG TCAGGCCCGG GACT
TCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCTTCAAG
AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGG
GCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT
GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTA
TGCC ACCAACCGGG GCAACCTTCG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA G
GAGACTTCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTG
TGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GA
AACGGTCG CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTT
CT GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC CCT
GGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG CCTGGAGTT
C CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACC
CTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT GGATACCCGG ACCACCTCGT
CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTTACCAGC TAGCC
AAAGT CACCATCGTG GACCACCACG CCGCCACGGC CTCTTTCATG AAGCACCTGG AGAATGAGCA
GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCAC
TCCT GTTTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC C
CCTGGAAGG GGAGTGCCGC CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCA
ACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TC
CTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAG
GC TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCT
GGTGCTG GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTTTGCAGC
T GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATA
AGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG
AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGTTCTGT GTGTTCGGGC TCGGC
TCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG
CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGG
CTGG GCCCAGGCTG CCTTCCAGGC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC G
CCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGG
CCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CA
ATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGAC
AC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA CCG
GCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGC
A GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGC
TGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC
AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTC
AGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT
GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCC
CCGG TACTACTCAG TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT G
TGCTGGCAT ACAGGACTCA GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAA
GCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CA
CCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTC
TG GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT GTT
CGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGG
G GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGG
ACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATGT
TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACG
GAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA
CCACGAAGAC ATTTTCGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAG
CTTT TCCTTGCAGG AGCGTCAGTT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA G
ACACCAACA GCCCCTGAGA GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTC
AGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TC
CAGAGGCT GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAG
GC CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGG
GCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT CTCAGGAGT
A TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATT ATTGAAGATT TACCATAAGG GACT
GTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC-3' (フラグメント番号1897
) (配列番号3017) 5'-CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT TGT
GGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGTT
C GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGG
TGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG
GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGA
CTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA
CTTTTTCATG TAAGAAGTGA TCATTTCCAT TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCA
CCAA AGCTTACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG T
GCCAATAGC CTTCCTTCCT TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAA
TAA TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TG
TCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATT
AA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGG
CCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTT
G GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAG
ATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC
ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGG
ATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA
AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTG
ATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT G
ACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C-3' (フラグメント
番号 )(配列番号2506) 5'-CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAG
TTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTG
C AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGT
AAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA AATTCCACCA GTATGCAATG
AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCCAGTCCA GTGAC
ACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG
AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGC
ATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA A
GGGATTTTA ACTTGCAGGT CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGA
GGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CA
ATATTACG GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAA
GG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC AGG
CCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT TCGATGCCC
G CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC GTTACTCCAC CAAC
AATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG ATGGCAAGCA CGACTTCCGG
GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGCATCAGA GGGGA
CCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG TACGGCCGCT
TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTG
ACCT TGTGCTTGAG GTGGCCATGG AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA G
TGGTACGCC CTGCCTGCAG TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGC
CCC TTCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TA
CAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAA
AG ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA CCA
TCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC GGTCCCGTG
G GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA TCACCCCCGT GTTT
CACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC AGGTAGAGGC CTGGAAAACC
CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGATTCCATT GAAAGTCTTG GTCAA
AGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA GTCACCATCC
TCTTTGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTG
CCTT CAACCCCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT G
CTGTTGGTG GTGACCAGTA CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAA
TCG CTCTTCATGC TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AG
CATGTACC CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTC
TC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT GGG
CCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA TTCAGATCC
C CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG TGCAGGACTC ACAG
CCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TGTTCACCAT GAGGCTCAAA
TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAACTCTCC TGTGA
GGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACCTTGGGGT TTGCCCAGGC AACCAGCCGG
CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGG
AGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG C
CAGGCCCTC ACCTACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCC
CAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AG
CAAGTGGA AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGT
GT CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT CCT
CCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA CCGGAGATG
G CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGCCCCAAGA CCCA
GTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA TCCTTGCATC
CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT TCTGGCAGCA ACGGCTCCAT GACTC
CCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTTTGG GTGCCGCCGC CCAGATGAGG
ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAG
CCTA TTCCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC C
AGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATG
GCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CA
GGTCGAGG ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGT
AT TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CGC
TCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA GCTCTGCAT
T ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTCAAGTCTT ATTT
CCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA GTAGCACCCT GGATTGATCG
GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG AGACAAAATC TTAAATGCCA GGCCT
GGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT GCACCACTTC AAGTGACCAC CAGGAGGTGC
TATCGCACCA CTGTGTATTT AACTGCCTTG TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTA
ACAC CCAGTCTGTT CCCCATGGCC ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT A
CATGAATTG CATTTTACTT TAATC-3' (フラグメント番号 )(配列番号2507) 5'-GAATTCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA GAG
CGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT GTGCGGCAA
G CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA GCGC
CAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG GCCCAAGTTC CCTCGTGTGA
AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCC
TGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT TCCACGGAAA CTACAGGGCC GGCCCTCCCC
CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTC
CATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA G
CCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACG
CTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GG
TCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTT
CG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA CAG
CCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC AGCCAACGT
G GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CTTCGACGTG CTGC
CCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT GCCCCCCGAG CTGGTCCTTG
AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC CCTGGGCCTG CGCTGGTACG CCCTC
CCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG
CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGA
GGAT GTGGCTGTCT GCATGGACCT GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA G
CAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACC
ACG CCGCCACGGC CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CT
GCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTTTCCATC AGGAGATG
GT CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAA
GGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTC
G CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG CTCCGAGACC GGCC
GGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC TTTTGATCCC CGGGTCCTGT
GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCTGGTGCTG GTGGTAACCA GCACA
TTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTTTGCAGCT GCCCTGATGG AGATGTCCGG
CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTC
CTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT G
CAGGGGCCC TGGGCACCCT CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCT
GCG CCTTTGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TG
GGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAG
GC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCC
CAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCC
A GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGC
AAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC
AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC CTTGTGGAGG CGCTG
CTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG
CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCA
GGCT CTCACCTTCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC A
CCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACG
AGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CG
CTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCG
GC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA GGA
TGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC CGGAGACCC
T GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC CAGCTTGCCC TGCA
TCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG GCAGGAGCGG CTGCATGACA
TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT GTTCGGCTGC CGATGCTCCC AACTT
GACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC
CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGC
TGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC A
TGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACG
AGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TC
ACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAG
TT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCC
GCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC CAGGATCAG
C CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT GCAAGGATTC AGCA
TTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAGGC CTGTTGCCTC GGGCCTGGGT
CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGGGCCTACT GCCACCCGCT TCCTG
TTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT
CTCTAAATCA AGTATTTATT ATTGAAGATT TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTA
CTAA AGTGCCTACC CCAGCTC-3' (フラグメント番号 )(配列番号2508) 5'-CCCCGGGG-3' (フラグメント番号1898) (配列番号1911) 5'-GGGGCCGCTGGG-3' (フラグメント番号1899) (配列番号1912) 5'-GGGGGTGTGG-3' (フラグメント番号1900) (配列番号1913) 5'-CTGCCTCCCCGGGGT-3' (フラグメント番号1442)(配列番号1451) 5'-TTCTGCTGCTTGCTG-3' (フラグメント番号1443)(配列番号1452) 5'-CTTCTTTCCCGTCTCC-3' (フラグメント番号1444)(配列番号1453) 5'-CTTCTTTCCCGTCTCC-3' (フラグメント番号1445)(配列番号1454) 5'-TTTTTGCCTCTTTG-3' (フラグメント番号1446)(配列番号1455) 5'-GGTTCCTGTTGTTTCT-3' (フラグメント番号1447)(配列番号1456) 5'-GGCCTGCTTGGTGGCG-3' (フラグメント番号1448)(配列番号1457) 5'-GCTTGTGCGTTTCC-3' (フラグメント番号1449)(配列番号1458) 5'-TCTCTCTTCTCTTGGGTCTCCGCTTCTCGTCCTGCC-3' (フラグメント番号1450)(配列番
号1459) 5'-TTTTCCTGTCTCTGTCGC-3' (フラグメント番号1451)(配列番号1460) 5'-GCCGTTCCTCCTCC-3' (フラグメント番号1452)(配列番号1461) 5'-GGCGTCCTCCTGCCC-3' (フラグメント番号1453)(配列番号1462) 5'-TGTGCTGTTTGCCTCGG-3' (フラグメント番号1454)(配列番号1463) 5'-GTGGTGCGGGTCCC-3' (フラグメント番号1455)(配列番号1464) 5'-GGTGCTCCCCCGGC-3' (フラグメント番号1456)(配列番号1465) 5'-GGGCCGGCTGGTTGCCTGGGC-3' (フラグメント番号1457)(配列番号1466) 5'-CTGTCTGGTGGGGTGTGGGGCC-3' (フラグメント番号1458)(配列番号1467) 5'-GCTGGGTTGGGGGTGTGGTG-3' (フラグメント番号1459)(配列番号1468) 5'-GGCTCTTCTGTGGCC-3' (フラグメント番号1460)(配列番号1469) 5'-TGTGGGGCTGTTGGTG-3' (フラグメント番号1461)(配列番号1470) 5'-TCTCTGTGGGCGTGTG-3' (フラグメント番号1462)(配列番号1471) 5'-CTGGGTCTTGGGGCTTC-3' (フラグメント番号1463)(配列番号1472) 5'-CTCCCTTGTGCTGGG-3' (フラグメント番号1464)(配列番号1473) 5'-TGCGGCCTCCCCGC-3' (フラグメント番号1465)(配列番号1474) 5'-CCCCCTTCTGGGCC-3' (フラグメント番号1466)(配列番号1475) 5'-GGTGGCCTGGCTCCTTGTGG-3' (フラグメント番号1467)(配列番号1476) 5'-GCGCTTCTGGCTCTTG-3' (フラグメント番号1468)(配列番号1477) 5'-CCCTGTCCTTCTTCGCCTCGT-3' (フラグメント番号1469)(配列番号1478) 5'-GGCTGCTGGGCTGC-3' (フラグメント番号1470)(配列番号1479) 5'-CTGCCCCBGTTTTTGBTCCTCBCBTGCCGTGGGGBGGBCBBTGG-3'(フラグメント番号1901) (配列番号1914) NF-kB核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGGGTTGGGC TTGGCCGGGG CTG
CCCGGTG CCTCCTCTTG GCTGGTCCCT CGTTGTCCTT GGGCCCCGC TCCCGCTGCT CGGCCTCCGT
GTTCTTTGGC CTCTTGCTCC GCCTGCTGTC TTGTCCCGTC CCCTCCTCGC TTGCGTTTCC CTCTT
CCTTG TCTTCCAGGC CTTCCTCCGC TTCCGCTGCT GGGGCCCGCG CCGGGGGGGC GCTCGGCTCC
GCGGCTTCCT CCCCGGCTGG GGGGTCCTGG TCTCCGGGGC CTGCGGCTCG CGGGCTCGGG GCTGCG
TGCG CCGCGCGCGG CGTCCGCGGT GGGTGGCGCT GTCCCGCCGT GGTGTGTCTC CGTTCTCGTC C
TGCGCCGTC CTGGTCTGCC CGTGGGGTCC TGGGCGTGGT GGGGGGCGTC TGGTGCCTCG TCTGCCC
CGT GGGGCTTCGG GCTCGGGGCT GTTCGTCCCC CCTGCCGCTC TGTGGCCTCC GGGGCTCCTC GT
TTTCGCTG CTTCGGGTGT CCTTCTCGGC GTGTGGCCCC GGGTCCCGGC CCTGCTGGGC TGGGCGGG
GT CGCTGCCCTG GGCTTCTGGC CCGTCTGGTT GTCTGTCGGT GCTTGTCTCG GGTTTCTGGC CTC
TGTGCTG GGCGCTTCTC TGCCTCCTGC TCCGCCCTCC TGGTGGCTCG GCTGGGGGTG CCCGTGCGG
G GGTGGGTGTG GGGTGTTTTC GGGGTCCTCC CCTTCCC-3' (フラグメント番号1902) (配
列番号1915) 5'-GGGCGGGGTCGC-3' (フラグメント番号1903) (配列番号1916) 5'-GCGCCGTCC-3' (フラグメント番号1904) (配列番号1917) 5'-GGGCGTGGTGG-3' (フラグメント番号1905) (配列番号1918) 5'-GTTGGGCTTGGCCGGGG-3' (フラグメント番号1471)(配列番号1480) 5'-CTGCCCGGTGCCTCC-3' (フラグメント番号1472)(配列番号1481) 5'-TCTTGGCTGGTCCCTCGT-3' (フラグメント番号1473)(配列番号1482) 5'-TGTCCTTGGGCCCC-3' (フラグメント番号1474)(配列番号1483) 5'-GCTCCCGCTGCTCGGCCTCCGT-3' (フラグメント番号1475)(配列番号1484) 5'-GTTCTTTGGCCTCTTGCTCC-3' (フラグメント番号1476)(配列番号1485) 5'-GCCTGCTGTCTTGTCC-3' (フラグメント番号1477)(配列番号1486) 5'-CGTCCCCTCCTCGCTTGCGTTTC-3' (フラグメント番号1478)(配列番号1487) 5'-CCTCTTCCTTGTCTTCCA-3' (フラグメント番号1479)(配列番号1488) 5'-GGCCTTCCTCCGCTTCCGCTGC-3' (フラグメント番号1480)(配列番号1489) 5'-TGGGGCCCGCGCCGG-3' (フラグメント番号1481)(配列番号1490) 5'-GGGGGCGCTCGGCTCCGCGGCTTCCTCCCCGG-3' (フラグメント番号1482)(配列番号14
91) 5'-CTGGGGGGTCCTGG-3' (フラグメント番号1483)(配列番号1492) 5'-TCTCCGGGGCCTGCGGCTCGC-3' (フラグメント番号1484)(配列番号1493) 5'-GGGCTCGGGGCTGCGTGCGCC-3' (フラグメント番号1485)(配列番号1494) 5'-GCGCGCGGCGTCCGCGGTG-3' (フラグメント番号1486)(配列番号1495) 5'-GGTGGCGCTGTCCCGCC-3' (フラグメント番号1487)(配列番号1496) 5'-GTGGTGTGTCTCCGTTCTCGTCCTGCGCCGTC-3' (フラグメント番号1488)(配列番号14
97) 5'-CTGGTCTGCCCGTGG-3' (フラグメント番号1489)(配列番号1498) 5'-GGTCCTGGGCGTGGTGG-3' (フラグメント番号1490)(配列番号1499) 5'-GGGGCGTCTGGTGC-3' (フラグメント番号1491)(配列番号1500) 5'-CTCGTCTGCCCCGTG-3' (フラグメント番号1492)(配列番号1501) 5'-GGGCTTCGGGCTCGG-3' (フラグメント番号1493)(配列番号1502) 5'-GGCTGTTCGTCCCCCCTGCCGCTCTGTGGCCTCC-3' (フラグメント番号1494)(配列番号
1503) 5'-GGGGCTCCTCGTTTTC-3' (フラグメント番号1495)(配列番号1504) 5'-GCTGCTTCGGGTGTCCTTCTC-3' (フラグメント番号1496)(配列番号1505) 5'-GGCGTGTGGCCCCGG-3' (フラグメント番号1497)(配列番号1506) 5'-GTCCCGGCCCTGCTGGGCTGGGCGGGGTC-3' (フラグメント番号1498)(配列番号1507)
5'-GCTGCCCTGGGCTTCTGGCCCGTCT-3' (フラグメント番号1499)(配列番号1508) 5'-GGTTGTCTGTCGGT-3' (フラグメント番号1500)(配列番号1509) 5'-GCTTGTCTCGGGTTTCTGG-3' (フラグメント番号1501)(配列番号1510) 5'-CCTCTGTGCTGGGC-3' (フラグメント番号1502)(配列番号1511) 5'-GCTTCTCTGCCTCCTGCTCC-3' (フラグメント番号1503)(配列番号1512) 5'-GCCCTCCTGGTGGCTC-3' (フラグメント番号1504)(配列番号1513) 5'-GGCTGGGGGTGCCCGTGCG-3' (フラグメント番号1505)(配列番号1514) 5'-GGGGTGGGTGTGGGGTGTT-3' (フラグメント番号1506)(配列番号1515) 5'-TTCGGGGTCCTCCCCTTCCC-3' (フラグメント番号1507)(配列番号1516) 5'-CGGCCCTTCTCACTGGAGGCACCGGGCAGTCCTCCATGGGAGG-3' (フラグメント番号1906)
(配列番号1919) ヒト主要塩基性タンパク質(Major Basic Protein)核酸およびアンチセンスオ
リゴヌクレオチドフラグメント 5'-GTT TCA TCT TGG CTT TAT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GR
G TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC
TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA GTT TCA TCT TGG GTT TCB TCT
TGG CTT TBT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC
CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG
GCC CTT CCC TGC TGG GGG GGB GTT TCB TCT TGG-3' (FRAG. ID:1907) (配列番
号1920) 5'-GGG GGA GTT-3' (FRAG. ID:1908) (配列番号1921) 5'-G CCC TGG GCC C-3' (FRAG. ID:1909) (配列番号1922) 5'-GTT TCA TCT TGG CTT TAT CC-3' (フラグメント番号1508) (配列番号1517) 5'-TCT CCC CTT GTT CCT CCC C-3' (フラグメント番号1509)(配列番号1518) 5'-TCT CCT GCT CTG GRG TCT CCT C-3' (フラグメント番号1510)(配列番号1519)
5'-TTC CCT CCC TCC CCT GCC-3' (フラグメント番号1511)(配列番号1520) 5'-GTG TTG TCT GTG GGT GTC C-3' (フラグメント番号1512)(配列番号1521) 5'-GTT TCG CTC TTG TTG CCC-3' (フラグメント番号1513)(配列番号1522) 5'-TGG GCC CTT CCC TGC TGG-3' (フラグメント番号1514)(配列番号1523) 5'-GGG GGA GTT TCA TCT TGG-3' (フラグメント番号1515)(配列番号1524) 5'-GTT TCA TCT TGG CTT TAT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GR
G TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC
TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA GTT TCA TCT TGG-3' (FRAG. ID
:1910) (配列番号1923) 5'-GTT TCB TCT TGG CTT TBT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GR
G TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC
TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGB GTT TCB TCT TGG-3' (FRAG. ID
:1911) (配列番号1924) ヒト好酸球主要塩基性タンパク質(Eosinophil Major Basic Protein)核酸およ びアンチセンスオリゴヌクレオチドフラグメント 5'-GGG GGB GTT TCB TCT TGG CTT T-3' (フラグメント番号1516)(配列番号1525)
5'-GGG GGB GTT TCB TCT TGG CTT-3' (フラグメント番号1517)(配列番号1526) 5'-GGG GGB GTT TCB TCT TGG CT-3' (フラグメント番号1518)(配列番号1527) 5'-GGG GGB GTT TCB TCT TGG C-3' (フラグメント番号1519)(配列番号1528) 5'-GGG GGB GTT TCB TCT TGG-3' (フラグメント番号1520)(配列番号1529) 5'-GGG GGB GTT TCB TCT TG-3' (フラグメント番号1521)(配列番号1530) 5'-GGG GGB GTT TCB TCT T-3' (フラグメント番号1522)(配列番号1531) 5'-GGG GGB GTT TCB TCT-3' (フラグメント番号1523)(配列番号1532) 5'-GGG GGB GTT TCB TC-3' (フラグメント番号1524)(配列番号1533) 5'-GGG GGB GTT TCB T-3' (フラグメント番号1525)(配列番号1534) 5'-GGG GGB GTT TCB-3' (フラグメント番号1526)(配列番号1535) 5'-GG GGB GTT TCB TCT TGG CTT T-3' (フラグメント番号1527)(配列番号1536)
5'-GG GGB GTT TCB TCT TGG CTT-3' (フラグメント番号1528)(配列番号1537) 5'-GG GGB GTT TCB TCT TGG CT-3' (フラグメント番号1529)(配列番号1538) 5'-GG GGB GTT TCB TCT TGG C-3' (フラグメント番号1530)(配列番号1539) 5'-GG GGB GTT TCB TCT TGG-3' (フラグメント番号1531)(配列番号1540) 5'-GG GGB GTT TCB TCT TG-3' (フラグメント番号1532)(配列番号1541) 5'-GG GGB GTT TCB TCT T-3' (フラグメント番号1533)(配列番号1542) 5'-GG GGB GTT TCB TCT-3' (フラグメント番号1534)(配列番号1543) 5'-GG GGB GTT TCB TC-3' (フラグメント番号1535)(配列番号1544) 5'-GG GGB GTT TCB T-3' (フラグメント番号1536)(配列番号1545) 5'-G GGB GTT TCB TCT TGG CTT T-3' (フラグメント番号1537)(配列番号1546) 5'-G GGB GTT TCB TCT TGG CTT-3' (フラグメント番号1538)(配列番号1547) 5'-G GGB GTT TCB TCT TGG CT-3' (フラグメント番号1539)(配列番号1548) 5'-G GGB GTT TCB TCT TGG C-3' (フラグメント番号1540)(配列番号1549) 5'-G GGB GTT TCB TCT TGG-3' (フラグメント番号1541)(配列番号1550) 5'-G GGB GTT TCB TCT TG-3' (フラグメント番号1542)(配列番号1551) 5'-G GGB GTT TCB TCT T-3' (フラグメント番号1543)(配列番号1552) 5'-G GGB GTT TCB TCT-3' (フラグメント番号1544)(配列番号1553) 5'-G GGB GTT TCB TC-3' (フラグメント番号1545)(配列番号1554) 5'-GGB GTT TCB TCT TGG CTT T-3' (フラグメント番号1546)(配列番号1555) 5'-GGB GTT TCB TCT TGG CTT-3' (フラグメント番号1547)(配列番号1556) 5'-GGB GTT TCB TCT TGG CT-3' (フラグメント番号1548)(配列番号1557) 5'-GGB GTT TCB TCT TGG C-3' (フラグメント番号1549)(配列番号1558) 5'-GGB GTT TCB TCT TGG-3' (フラグメント番号1550)(配列番号1559) 5'-GGB GTT TCB TCT TG-3' (フラグメント番号1551)(配列番号1560) 5'-GGB GTT TCB TCT T-3' (フラグメント番号1552)(配列番号1561) 5'-GGB GTT TCB TCT-3' (フラグメント番号1553)(配列番号1562) 5'-GB GTT TCB TCT TGG CTT T-3' (フラグメント番号1554)(配列番号1563) 5'-GB GTT TCB TCT TGG CTT-3' (フラグメント番号1555)(配列番号1564) 5'-GB GTT TCB TCT TGG CT-3' (フラグメント番号1556)(配列番号1565) 5'-GB GTT TCB TCT TGG C-3' (フラグメント番号1557)(配列番号1566) 5'-GB GTT TCB TCT TGG-3' (フラグメント番号1558)(配列番号1567) 5'-GB GTT TCB TCT TG-3' (フラグメント番号1559)(配列番号1568) 5'-GB GTT TCB TCT T-3' (フラグメント番号1560)(配列番号1569) 5'-B GTT TCB TCT TGG CTT T-3' (フラグメント番号1561)(配列番号1570) 5'-B GTT TCB TCT TGG CTT-3' (フラグメント番号1562)(配列番号1571) 5'-B GTT TCB TCT TGG CTT-3' (フラグメント番号1563)(配列番号1572) 5'-B GTT TCB TCT TGG CT-3' (フラグメント番号1564)(配列番号1573) 5'-B GTT TCB TCT TGG C-3' (フラグメント番号1565)(配列番号1574) 5'-B GTT TCB TCT TGG-3' (フラグメント番号1565)(配列番号1575) 5'-B GTT TCB TCT TG-3' (フラグメント番号1567)(配列番号1576) 5'-GTT TCB TCT TGG CTT T-3' (フラグメント番号1568)(配列番号1577) 5'-GTT TCB TCT TGG CTT-3' (フラグメント番号1569)(配列番号1578) 5'-GTT TCB TCT TGG CT-3' (フラグメント番号1570)(配列番号1579) 5'-GTT TCB TCT TGG C-3' (フラグメント番号1571)(配列番号1580) 5'-GTT TCB TCT TGG-3' (フラグメント番号1572)(配列番号1581) 5'-TT TCB TCT TGG CTT T-3' (フラグメント番号1573)(配列番号1582) 5'-TT TCB TCT TGG CTT-3' (フラグメント番号1574)(配列番号1583) 5'-TT TCB TCT TGG CT-3' (フラグメント番号1575)(配列番号1584) 5'-TT TCB TCT TGG C-3' (フラグメント番号1576)(配列番号1585) 5'-T TCB TCT TGG CTT T-3' (フラグメント番号1577)(配列番号1586) 5'-T TCB TCT TGG CTT-3' (フラグメント番号1578)(配列番号1587) 5'-T TCB TCT TGG CT-3' (フラグメント番号1579)(配列番号1588) 5'-TCB TCT TGG CTT T-3' (フラグメント番号1580)(配列番号1589) 5'-TCB TCT TGG CTT-3' (フラグメント番号1581)(配列番号1590) 5'-GGG GGB GTT TCB TCT TGG CTT T-3' (フラグメント番号1582)(配列番号1591)
5'-GG GGB GTT TCB TCT TGG CTT T-3' (フラグメント番号1583)(配列番号1592)
5'-G GGB GTT TCB TCT TGG CTT T-3' (フラグメント番号1584)(配列番号1593) 5'-GGB GTT TCB TCT TGG CTT T-3' (フラグメント番号1585)(配列番号1594) 5'-GB GTT TCB TCT TGG CTT T-3' (フラグメント番号1586)(配列番号1595) 5'-B GTT TCB TCT TGG CTT T-3' (フラグメント番号1587)(配列番号1596) 5'-GTT TCB TCT TGG CTT T-3' (フラグメント番号1588)(配列番号1597) 5'-TT TCB TCT TGG CTT T-3' (フラグメント番号1589)(配列番号1598) 5'-T TCB TCT TGG CTT T-3' (フラグメント番号1590)(配列番号1599) 5'-TCB TCT TGG CTT T-3' (フラグメント番号1591)(配列番号1600) 5'-CB TCT TGG CTT T-3' (フラグメント番号1592)(配列番号1601) 5'-GGG GGB GTT TCB TCT TGG CTT-3' (フラグメント番号1593)(配列番号1602) 5'-GG GGB GTT TCB TCT TGG CTT-3' (フラグメント番号1594)(配列番号1603) 5'-G GGB GTT TCB TCT TGG CTT-3' (フラグメント番号1595)(配列番号1604) 5'-GGB GTT TCB TCT TGG CTT-3' (フラグメント番号1596)(配列番号1605) 5'-GB GTT TCB TCT TGG CTT-3' (フラグメント番号1597)(配列番号1606) 5'-B GTT TCB TCT TGG CTT-3' (フラグメント番号1598)(配列番号1607) 5'-GTT TCB TCT TGG CTT-3' (フラグメント番号1599)(配列番号1608) 5'-TT TCB TCT TGG CTT-3' (フラグメント番号1600)(配列番号1609) 5'-T TCB TCT TGG CTT-3' (フラグメント番号1601)(配列番号1610) 5'-TCB TCT TGG CTT-3' (フラグメント番号1602)(配列番号1611) 5'-GGG GGB GTT TCB TCT TGG CT-3' (フラグメント番号1603)(配列番号1612) 5'-GG GGB GTT TCB TCT TGG CT-3' (フラグメント番号1604)(配列番号1613) 5'-G GGB GTT TCB TCT TGG CT-3' (フラグメント番号1605)(配列番号1614) 5'-GGB GTT TCB TCT TGG CT-3' (フラグメント番号1606)(配列番号1615) 5'-GB GTT TCB TCT TGG CT-3' (フラグメント番号1607)(配列番号1616) 5'-B GTT TCB TCT TGG CT-3' (フラグメント番号1608)(配列番号1617) 5'-GTT TCB TCT TGG CT-3' (フラグメント番号1609)(配列番号1618) 5'-TT TCB TCT TGG CT-3' (フラグメント番号1610)(配列番号1619) 5'-T TCB TCT TGG CT-3' (フラグメント番号1611)(配列番号1620) 5'-GGG GGB GTT TCB TCT TGG C-3' (フラグメント番号1612)(配列番号1621) 5'-GG GGB GTT TCB TCT TGG C-3' (フラグメント番号1613)(配列番号1622) 5'-G GGB GTT TCB TCT TGG C-3' (フラグメント番号1614)(配列番号1623) 5'-GGB GTT TCB TCT TGG C-3' (フラグメント番号1615)(配列番号1624) 5'-GB GTT TCB TCT TGG C-3' (フラグメント番号1616)(配列番号1625) 5'-B GTT TCB TCT TGG C-3' (フラグメント番号1617)(配列番号1626) 5'-GTT TCB TCT TGG C-3' (フラグメント番号1618)(配列番号1627) 5'-TT TCB TCT TGG C-3' (フラグメント番号1619)(配列番号1628) 5'-GGG GGB GTT TCB TCT TGG-3' (フラグメント番号1620)(配列番号1629) 5'-GG GGB GTT TCB TCT TGG-3' (フラグメント番号1621)(配列番号1630) 5'-G GGB GTT TCB TCT TGG-3' (フラグメント番号1622)(配列番号1631) 5'-GGB GTT TCB TCT TGG-3' (フラグメント番号1623)(配列番号1632) 5'-GB GTT TCB TCT TGG-3' (フラグメント番号1624)(配列番号1633) 5'-B GTT TCB TCT TGG-3' (フラグメント番号1625)(配列番号1634) 5'-GTT TCB TCT TGG-3' (フラグメント番号1626)(配列番号1635) 5'-GGG GGB GTT TCB TCT TG-3' (フラグメント番号1627)(配列番号1636) 5'-GG GGB GTT TCB TCT TG-3' (フラグメント番号1628)(配列番号1637) 5'-G GGB GTT TCB TCT TG-3' (フラグメント番号1629)(配列番号1638) 5'-GGB GTT TCB TCT TG-3' (フラグメント番号1630)(配列番号1639) 5'-GB GTT TCB TCT TG-3' (フラグメント番号1631)(配列番号1640) 5'-B GTT TCB TCT TG-3' (フラグメント番号1632)(配列番号1641) 5'-GGG GGB GTT TCB TCT T-3' (フラグメント番号1633)(配列番号1642) 5'-GG GGB GTT TCB TCT T-3' (フラグメント番号1634)(配列番号1643) 5'-G GGB GTT TCB TCT T-3' (フラグメント番号1635)(配列番号1644) 5'-G GGB GTT TCB TCT T-3' (フラグメント番号1636)(配列番号1645) 5'-GGB GTT TCB TCT T-3' (フラグメント番号1637)(配列番号1646) 5'-GB GTT TCB TCT T-3' (フラグメント番号1638)(配列番号1647) 5'-GGG GGB GTT TCB TCT-3' (フラグメント番号1639)(配列番号1648) 5'-GG GGB GTT TCB TCT-3' (フラグメント番号1640)(配列番号1649) 5'-G GGB GTT TCB TCT-3' (フラグメント番号1641)(配列番号1650) 5'-GGB GTT TCB TCT-3' (フラグメント番号1642)(配列番号1651) 5'-GGG GGB GTT TCB TC-3' (フラグメント番号1643)(配列番号1652) 5'-GG GGB GTT TCB TC-3' (フラグメント番号1644)(配列番号1653) 5'-G GGB GTT TCB TC-3' (フラグメント番号1645)(配列番号1654) 5'-GGG GGB GTT TCB T-3' (フラグメント番号1646)(配列番号1655) 5'-GG GGB GTT TCB T-3' (フラグメント番号1647)(配列番号1656) 5'-GGG GGB GTT TCB-3' (フラグメント番号1648)(配列番号1657) 5'-TCT CCC CTT GTT CCT CCC C-3' (フラグメント番号1649)(配列番号1658) 5'-TCT CCT GCT CTG GTG TCT CCT C-3' (フラグメント番号1650)(配列番号1659)
5'-TTC CCT CCC TCC CCT GCC-3' (フラグメント番号1651)(配列番号1660) 5'-GTG TTG TCT GTG GGT GTC C-3' (フラグメント番号1652)(配列番号1661) 5'-GTT TCG CTC TTG TTG CCC-3' -3' (フラグメント番号1653)(配列番号1661) 5'-TGG GCC CTT CCC TGC TGG-3' (フラグメント番号1654)(配列番号1663) 5'-GGG GGB G-3' (フラグメント番号1912)(配列番号1925) 5'-GTG GGT GTC C-3' (フラグメント番号1913) (配列番号1926) BP-1核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTG
TTTTCCG TTTCTCTTGC CGTCTGTGGT T-3' (フラグメント番号1914) (配列番号1927)
5'-CCCGTTTGBGGTBTGGC-3'(フラグメント番号1915) (配列番号1928) 5'-GCTCCBCCBBTTCCCTTTTCTCC-3'(フラグメント番号1916) (配列番号1929) 5'-TTGTTTTCCGTTTCTCTTG-3'(フラグメント番号1917) (配列番号1930) 5'-CCGTCTGTGGTT-3'(フラグメント番号1918) (配列番号1931) 5'-CCCGTTTGAGGTATGGC-3'(フラグメント番号1919) (配列番号1932) 5'-GCTCCBCCAATTCCCTTTTCTCC-3'(フラグメント番号1920) (配列番号1933) C/EBP核酸およびアンチセンスオリゴヌクレオチドアンチセンスオリゴヌクレ
オチドフラグメント 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCCC GGCC-3' (フラグメント番号1921) (配列番
号1934) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCCC GGC-3' (フラグメント番号1922) (配列番
号1935) 5'-GGGCCCB GCCCCGCCGCCTTTTCTBGCCCCGG-3' (フラグメント番号1923) (配列番号
1936) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCCCG-3' (フラグメント番号1924) (配列番号19
37) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCCC-3' (フラグメント番号1925) (配列番号193
8) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCC-3' (フラグメント番号1926) (配列番号1939
) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCC-3' (フラグメント番号1927) (配列番号1940) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGC-3' (フラグメント番号1928) (配列番号1941)
5'-GGGCCCBGCCCCGCCGCCTTTTCTBG-3' (フラグメント番号1929) (配列番号1942)
5'-GGGCCCBGCCCCGCCGCCTTTTCTB-3' (フラグメント番号1930) (配列番号1943) 5'-GGGCCCBGCCCCGCCGCCTTTTCT-3' (フラグメント番号1931) (配列番号1942) 194
4) 5'-GGGCCCBGCCCCGCCGCCTTTTC-3' (フラグメント番号1932) (配列番号1945) 5'-GGGCCCBGCCCCGCCGCCTTTT-3' (フラグメント番号1933) (配列番号1946) 5'-GGGCCCBGCCCCGCCGCCTTT-3' (フラグメント番号1934) (配列番号1947) [1945)
] 5'-GGGCCCBGCCCCGCCGCCTT-3' (フラグメント番号1935) (配列番号1948) 5'-GGGCCCBGCCCCGCCGCCT-3' (フラグメント番号1936) (配列番号1949) 5'-GGGCCCBGCCCCGCCGCC-3' (フラグメント番号1937) (配列番号1950) 5'-GGGCCCBGCCCCGCCGC-3' (フラグメント番号1938) (配列番号1951) 5'-GGGCCCBGCCCCGCCG-3' (フラグメント番号1939) (配列番号1952) 5'-GGGCCCBGCCCCGCC-3' (フラグメント番号1940) (配列番号1953) 5'-GGGCCCBGCCCCGC-3' (フラグメント番号1941) (配列番号1954) 5'-GGGCCCBGCCCCG-3' (フラグメント番号1942) (配列番号1955) 5'-GGGCCCBGCCCC-3' (フラグメント番号1943) (配列番号1956) 5'-GGGCCCBGCCC-3' (フラグメント番号1944) (配列番号1957) 5'-GGCCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1945) (配列番号1
958) 5'-GCCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1946) (配列番号19
59) 5'-CCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1947) (配列番号196
0) 5'-CCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1948) (配列番号1961
) 5'-CBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1948) (配列番号1962)
5'-BGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1950) (配列番号1963)
5'-GCCCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1951) (配列番号1964)
5'-CCCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1952) (配列番号1965) 5'-CCCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1953) (配列番号1966) 5'-CCGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1954) (配列番号1967) 5'-CGCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1955) (配列番号1968) 5'-GCCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1956) (配列番号1969) 5'-CCGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1957) (配列番号1970) 5'-CGCCTTTTCTBGCCCCGGC-3' (フラグメント番号1958) (配列番号1971) 5'-GCCTTTTCTBGCCCCGGC-3' (フラグメント番号1959) (配列番号1972) 5'-CCTTTTCTBGCCCCGGC-3' (フラグメント番号1960) (配列番号1973) 5'-CTTTTCTBGCCCCGGC-3' (フラグメント番号1961) (配列番号1974) 5'-TTTTCTBGCCCCGGC-3' (フラグメント番号1962) (配列番号1975) 5'-TTTCTBGCCCCGGC-3' (フラグメント番号1963) (配列番号1976) 5'-TTCTBGCCCCGGC-3' (フラグメント番号1964) (配列番号1977) 5'-TCTBGCCCCGGC-3' (フラグメント番号1965) (配列番号1978) 5'-CTBGCCCCGGC-3' (フラグメント番号1966) (配列番号1979) 5'-GCGBGGCTGTCBCCTCGCTGGGCCC-3' (フラグメント番号1967) (配列番号1980) 5'-GCGBGGCTGTCBCCTCGCTGGGCC-3' (フラグメント番号1968) (配列番号1981) 5'-GCGBGGCTGTCBCCTCGCTGGGC-3' (フラグメント番号1969) (配列番号1982) 5'-GCGBGGCTGTCBCCTCGCTGGG-3' (フラグメント番号1970) (配列番号1983) 5'-GCGBGGCTGTCBCCTCGCTGG-3' (フラグメント番号1971) (配列番号1984) 5'-GCGBGGCTGTCBCCTCGCTG-3' (フラグメント番号1972) (配列番号1985) 5'-GCGBGGCTGTCBCCTCGCT-3' (フラグメント番号1973) (配列番号1986) 5'-GCGBGGCTGTCBCCTCGC-3' (フラグメント番号1974) (配列番号1987) 5'-GCGBGGCTGTCBCCTCG-3' (フラグメント番号1975) (配列番号1988) 5'-GCGBGGCTGTCBCCTC-3' (フラグメント番号1976) (配列番号1989) 5'-GCGBGGCTGTCBCCT-3' (フラグメント番号1977) (配列番号1990) 5'-GCGBGGCTGTCBCC-3' (フラグメント番号1978) (配列番号1991) 5'-GCGBGGCTGTCBC-3' (フラグメント番号1979) (配列番号1992) 5'-GCGBGGCTGTCB-3' (フラグメント番号1980) (配列番号1993) 5'-GCGBGGCTGTC-3' (フラグメント番号1981) (配列番号1994) 5'-GCGBGGCTGT-3' (フラグメント番号1982) (配列番号1995) 5'-CGBGGCTGTCBCCTCGCTGGGCCC-3' (フラグメント番号1983) (配列番号1996) 5'-GBGGCTGTCBCCTCGCTGGGCCC-3' (フラグメント番号1984) (配列番号1997) 5'-BGGCTGTCBCCTCGCTGGGCCC-3' (フラグメント番号1985) (配列番号1998) 5'-GGCTGTCBCCTCGCTGGGCCC-3' (フラグメント番号1986) (配列番号1999) 5'-GCTGTCBCCTCGCTGGGCCC-3' (フラグメント番号1987) (配列番号2000) 5'-CTGTCBCCTCGCTGGGCCC-3' (フラグメント番号1988) (配列番号2001) 5'-TGTCBCCTCGCTGGGCCC-3' (フラグメント番号1989) (配列番号2002) 5'-GTCBCCTCGCTGGGCCC-3' (フラグメント番号1990) (配列番号2003) 5'-TCBCCTCGCTGGGCCC-3' (フラグメント番号1991) (配列番号2004) 5'-CBCCTCGCTGGGCCC-3' (フラグメント番号1992) (配列番号2005) 5'-BCCTCGCTGGGCCC-3' (フラグメント番号1993) (配列番号2006) 5'-CCTCGCTGGGCCC-3' (フラグメント番号1994) (配列番号2007) 5'-CTCGCTGGGCCC-3' (フラグメント番号1995) (配列番号2008) 5'-TCGCTGGGCCC-3' (フラグメント番号1996) (配列番号2009) 5'-CGCTGGGCCC-3' (フラグメント番号1997) (配列番号2010) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号1998) (配列番号20
11) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGGG-3' (フラグメント番号1999) (配列番号201
2) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGG-3' (フラグメント番号2000) (配列番号2013
) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCG-3' (フラグメント番号2001) (配列番号2014)
5'-GCGCGGCCGTCBTGGCGGCGTCGGGCC-3' (フラグメント番号2002) (配列番号2015)
5'-GCGCGGCCGTCBTGGCGGCGTCGGGC-3' (フラグメント番号2003) (配列番号2016)
5'-GCGCGGCCGTCBTGGCGGCGTCGGG-3' (フラグメント番号2004) (配列番号2017) 5'-GCGCGGCCGTCBTGGCGGCGTCGG-3' (フラグメント番号2005) (配列番号2018) 5'-GCGCGGCCGTCBTGGCGGCGTCG-3' (フラグメント番号2006) (配列番号2019) 5'-GCGCGGCCGTCBTGGCGGCGTC-3' (フラグメント番号2007) (配列番号2020) 5'-GCGCGGCCGTCBTGGCGGCGT-3' (フラグメント番号2008) (配列番号2021) 5'-GCGCGGCCGTCBTGGCGGCG-3' (フラグメント番号2009) (配列番号2022) 5'-GCGCGGCCGTCBTGGCGGC-3' (フラグメント番号2010) (配列番号2023) 5'-GCGCGGCCGTCBTGGCGG-3' (フラグメント番号2011) (配列番号2024) 5'-GCGCGGCCGTCBTGGCG-3' (フラグメント番号2012) (配列番号2025) 5'-GCGCGGCCGTCBTGGC-3' (フラグメント番号2013) (配列番号2026) 5'-GCGCGGCCGTCBTGG-3' (フラグメント番号2014) (配列番号2027) 5'-GCGCGGCCGTCBTG-3' (フラグメント番号2015) (配列番号2028) 5'-GCGCGGCCGTCBT-3' (フラグメント番号2016) (配列番号2029) 5'-GCGCGGCCGTCB-3' (フラグメント番号2017) (配列番号2030) 5'-GCGCGGCCGTC-3' (フラグメント番号2018) (配列番号2031) 5'-GCGCGGCCGT-3' (フラグメント番号2019) (配列番号2032) 5'-CGCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2020) (配列番号203
3) 5'-GCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2021) (配列番号2034
) 5'-CGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2022) (配列番号2035)
5'-GGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2023) (配列番号2036)
5'-GCCGTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2024) (配列番号2037) 5'-CCGTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2025) (配列番号2038) 5'-CGTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2026) (配列番号2039) 5'-GTCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2027) (配列番号2040) 5'-TCBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2028) (配列番号2041) 5'-CBTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2029) (配列番号2042) 5'-BTGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2030) (配列番号2043) 5'-TGGCGGCGTCGGGCCGGGC-3' (フラグメント番号2031) (配列番号2044) 5'-GGCGGCGTCGGGCCGGGC-3' (フラグメント番号2032) (配列番号2045) 5'-GCGGCGTCGGGCCGGGC-3' (フラグメント番号2033) (配列番号2046) 5'-CGGCGTCGGGCCGGGC-3' (フラグメント番号2034) (配列番号2047) 5'-GGCGTCGGGCCGGGC-3' (フラグメント番号2035) (配列番号2048) 5'-GCGTCGGGCCGGGC-3' (フラグメント番号2036) (配列番号2049) 5'-CGTCGGGCCGGGC-3' (フラグメント番号2037) (配列番号2050) 5'-GTCGGGCCGGGC-3' (フラグメント番号2038) (配列番号2051) 5'-TCGGGCCGGGC-3' (フラグメント番号2039) (配列番号2052) 5'-CGGGCCGGGC-3' (フラグメント番号2040) (配列番号2053) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2041) (配列番号2
054) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGCC-3' (フラグメント番号2042) (配列番号20
55) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGC-3' (フラグメント番号2043) (配列番号205
6) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGG-3' (フラグメント番号2044) (配列番号2057
) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGG-3' (フラグメント番号2045) (配列番号2058)
5'-CCGCBGGCCBGGGCGCGCCGCCGGCCG-3' (フラグメント番号2046) (配列番号2059)
5'-CCGCBGGCCBGGGCGCGCCGCCGGCC-3' (フラグメント番号2047) (配列番号2060) 5'-CCGCBGGCCBGGGCGCGCCGCCGGC-3' (フラグメント番号2048) (配列番号2061) 5'-CCGCBGGCCBGGGCGCGCCGCCGG-3' (フラグメント番号2049) (配列番号2062) 5'-CCGCBGGCCBGGGCGCGCCGCCG-3' (フラグメント番号2050) (配列番号2063) 5'-CCGCBGGCCBGGGCGCGCCGCC-3' (フラグメント番号2051) (配列番号2064) 5'-CCGCBGGCCBGGGCGCGCCGC-3' (フラグメント番号2052) (配列番号2065) 5'-CCGCBGGCCBGGGCGCGCCG-3' (フラグメント番号2053) (配列番号2066) 5'-CCGCBGGCCBGGGCGCGCC-3' (フラグメント番号2054) (配列番号2067) 5'-CCGCBGGCCBGGGCGCGC-3' (フラグメント番号2055) (配列番号2068) 5'-CCGCBGGCCBGGGCGCG-3' (フラグメント番号2056) (配列番号2069) 5'-CCGCBGGCCBGGGCGC-3' (フラグメント番号2057) (配列番号2070) 5'-CCGCBGGCCBGGGCG-3' (フラグメント番号2058) (配列番号2071) 5'-CCGCBGGCCBGGGC-3' (フラグメント番号2059) (配列番号2072) 5'-CCGCBGGCCBGGG-3' (フラグメント番号2060) (配列番号2073) 5'-CCGCBGGCCBGG-3' (フラグメント番号2061) (配列番号2074) 5'-CCGCBGGCCBG-3' (フラグメント番号2062) (配列番号2075) 5'-CCGCBGGCCB-3' (フラグメント番号2063) (配列番号2076) 5'-CCGCBGGCC-3' (フラグメント番号2064) (配列番号2077) 5'-CGCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2065) (配列番号20
78) 5'-GCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2066) (配列番号207
9) 5'-CBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2067) (配列番号2080
) 5'-BGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2068) (配列番号2081) 5'-GGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2069) (配列番号2082)
5'-GCCBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2070) (配列番号2083) 5'-CCBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2071) (配列番号2084) 5'-CBGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2072) (配列番号2085) 5'-BGGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2073) (配列番号2086) 5'-GGGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2074) (配列番号2087) 5'-GGCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2075) (配列番号2088) 5'-GCGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2076) (配列番号2089) 5'-CGCGCCGCCGGCCGGGCCG-3' (フラグメント番号2077) (配列番号2090) 5'-GCGCCGCCGGCCGGGCCG-3' (フラグメント番号2078) (配列番号2091) 5'-CGCCGCCGGCCGGGCCG-3' (フラグメント番号2079) (配列番号2092) 5'-GCCGCCGGCCGGGCCG-3' (フラグメント番号2080) (配列番号2093) 5'-CCGCCGGCCGGGCCG-3' (フラグメント番号2081) (配列番号2094) 5'-CGCCGGCCGGGCCG-3' (フラグメント番号2082) (配列番号2095) 5'-GCCGGCCGGGCCG-3' (フラグメント番号2083) (配列番号2096) 5'-CCGGCCGGGCCG-3' (フラグメント番号2084) (配列番号2097) 5'-CGGCCGGGCCG-3' (フラグメント番号2085) (配列番号2098) 5'-GGCCGGGCCG-3' (フラグメント番号2086) (配列番号2099) 5'-GGGCGCBGGCTCCGCB-3' (フラグメント番号2087) (配列番号2100) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3'(フラグメント番号208
8)(配列番号2101) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCG-3' (フラグメント番号208
9)(配列番号2102) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCC-3' (フラグメント番号2090
)(配列番号2103) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCC-3' (フラグメント番号2091) (配列番号2104) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGC-3' (フラグメント番号2092)
(配列番号2105) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGG-3' (フラグメント番号2093) (
配列番号2106) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCG-3' (フラグメント番号2094) (
配列番号2107) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCC-3' (フラグメント番号2095) (配
列番号2108) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCC-3' (フラグメント番号2096) (配
列番号2109) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGC-3' (フラグメント番号2097) (配列
番号2110) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCG-3' (フラグメント番号2098) (配列
番号2111) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCC-3' (フラグメント番号2099) (配列番
号2112) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCC-3' (フラグメント番号2100) (配列番
号2113) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGC-3' (フラグメント番号2101) (配列番号
2114) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTG-3' (フラグメント番号2102) (配列番号2
115) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTT-3' (フラグメント番号2103) (配列番号21
16) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCT-3' (フラグメント番号2104) (配列番号211
7) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGC-3' (フラグメント番号2105) (配列番号2118
) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGG-3' (フラグメント番号2106) (配列番号2119) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCG-3' (フラグメント番号2107) (配列番号2120)
5'-GGGCCCCTGGCTCGGCCCCGCGGCCC-3' (フラグメント番号2108) (配列番号2121)
5'-GGGCCCCTGGCTCGGCCCCGCGGCC-3' (フラグメント番号2109) (配列番号2122) 5'-GGGCCCCTGGCTCGGCCCCGCGGC-3' (フラグメント番号2110) (配列番号2123) 5'-GGGCCCCTGGCTCGGCCCCGCGG-3' (フラグメント番号2111) (配列番号2124) 5'-GGGCCCCTGGCTCGGCCCCGCG-3' (フラグメント番号2112) (配列番号2125) 5'-GGGCCCCTGGCTCGGCCCCGC-3' (フラグメント番号2113) (配列番号2126) 5'-GGGCCCCTGGCTCGGCCCCG-3' (フラグメント番号2114) (配列番号2127) 5'-GGGCCCCTGGCTCGGCCCC-3' (フラグメント番号2115) (配列番号2128) 5'-GGGCCCCTGGCTCGGCCC-3' (フラグメント番号2116) (配列番号2129) 5'-GGGCCCCTGGCTCGGCC-3' (フラグメント番号2117) (配列番号2130) 5'-GGGCCCCTGGCTCGGC-3' (フラグメント番号2118) (配列番号2131) 5'-GGGCCCCTGGCTCGG-3' (フラグメント番号2119) (配列番号2132) 5'-GGGCCCCTGGCTCG-3' (フラグメント番号2120) (配列番号2133) 5'-GGGCCCCTGGCTC-3' (フラグメント番号2121) (配列番号2134) 5'-GGGCCCCTGGCT-3' (フラグメント番号2122) (配列番号2135) 5'-GGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3'(フラグメント番号2123
)(配列番号2136) 5'-GCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2124
) (配列番号2137) 5'-CCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2125) (配列番号2138) 5'-CCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2126)
(配列番号2139) 5'-CCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2127) (
配列番号2140) 5'-CTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2128) (
配列番号2141) 5'-TGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2129) (配
列番号2142) 5'-GGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2130) (配
列番号2143) 5'-GCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2131) (配列
番号2144) 5'-CTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2132) (配列
番号2145) 5'-TCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2133) (配列番
号2146) 5'-CGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2134) (配列番
号2147) 5'-GGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2135) (配列番号
2148) 5'-GCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2136) (配列番号2
149) 5'-CCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2137) (配列番号21
50) 5'-CCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2138) (配列番号215
1) 5'-CCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2139) (配列番号2152
) 5'-CGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2140) (配列番号2153)
5'-GCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2141) (配列番号2154)
5'-CGGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2142) (配列番号2155)
5'-GGCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2143) (配列番号2156) 5'-GCCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2144) (配列番号2157) 5'-CCCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2145) (配列番号2158) 5'-CCGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2146) (配列番号2159) 5'-CGGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2147) (配列番号2160) 5'-GGCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2148) (配列番号2161) 5'-GCTTGCCCGCCCGGCCCGG-3' (フラグメント番号2149) (配列番号2162) 5'-CTTGCCCGCCCGGCCCGG-3' (フラグメント番号2150) (配列番号2163) 5'-TTGCCCGCCCGGCCCGG-3' (フラグメント番号2151) (配列番号2164) 5'-TGCCCGCCCGGCCCGG-3' (フラグメント番号2152) (配列番号2165) 5'-GCCCGCCCGGCCCGG-3' (フラグメント番号2153) (配列番号2166) 5'-CCCGCCCGGCCCGG-3' (フラグメント番号2154) (配列番号2167) 5'-CCGCCCGGCCCGG-3' (フラグメント番号2155) (配列番号2168) 5'-CGCCCGGCCCGG-3' (フラグメント番号2156) (配列番号2169) 5'-GCCCGGCCCGG-3' (フラグメント番号2157) (配列番号2170) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2158) (配列
番号2171) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCC-3' (フラグメント番号2159) (配列番
号2172) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCC-3' (フラグメント番号2160) (配列番
号2173) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGC-3' (フラグメント番号2161) (配列番号
2174) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGG-3' (フラグメント番号2162) (配列番号2
175) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGG-3' (フラグメント番号2163) (配列番号21
76) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBG-3' (フラグメント番号2164) (配列番号217
7) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTB-3' (フラグメント番号2165) (配列番号2178
) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCT-3' (フラグメント番号2166) (配列番号2179)
5'-GGCGGGGGCGGCGGCGCCTGGCTCGCC-3' (フラグメント番号2167) (配列番号2180)
5'-GGCGGGGGCGGCGGCGCCTGGCTCGC-3' (フラグメント番号2168) (配列番号2181)
5'-GGCGGGGGCGGCGGCGCCTGGCTCG-3' (フラグメント番号2169) (配列番号2182) 5'-GGCGGGGGCGGCGGCGCCTGGCTC-3' (フラグメント番号2170) (配列番号2183) 5'-GGCGGGGGCGGCGGCGCCTGGCT-3' (フラグメント番号2171) (配列番号2184) 5'-GGCGGGGGCGGCGGCGCCTGGC-3' (フラグメント番号2172) (配列番号2185) 5'-GGCGGGGGCGGCGGCGCCTGG-3' (フラグメント番号2173) (配列番号2186) 5'-GGCGGGGGCGGCGGCGCCTG-3' (フラグメント番号2174) (配列番号2187) 5'-GGCGGGGGCGGCGGCGCCT-3' (フラグメント番号2175) (配列番号2188) 5'-GGCGGGGGCGGCGGCGCC-3' (フラグメント番号2176) (配列番号2189) 5'-GGCGGGGGCGGCGGCGC-3' (フラグメント番号2177) (配列番号2190) 5'-GGCGGGGGCGGCGGCG-3' (フラグメント番号2178) (配列番号2191) 5'-GGCGGGGGCGGCGGC-3' (フラグメント番号2179) (配列番号2192) 5'-GGCGGGGGCGGCGG-3' (フラグメント番号2180) (配列番号2193) 5'-GGCGGGGGCGGCG-3' (フラグメント番号2181) (配列番号2194) 5'-GGCGGGGGCGGC-3' (フラグメント番号2182) (配列番号2195) 5'-GGCGGGGGCGG-3' (フラグメント番号2183) (配列番号2196) 5'-GCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2184) (配列番
号2197) 5'-CGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2185) (配列番
号2198) 5'-GGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2186) (配列番号
2199) 5'-GGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2187) (配列番号2
200) 5'-GGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2188) (配列番号22
01) 5'-GGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2189) (配列番号220
2) 5'-GCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2190) (配列番号2203
) 5'-CGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2191) (配列番号2204)
5'-GGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2192) (配列番号2205)
5'-GCGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2193) (配列番号2206)
5'-CGGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2194) (配列番号2207) 5'-GGCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2195) (配列番号2208) 5'-GCGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2196) (配列番号2209) 5'-CGCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2197) (配列番号2210) 5'-GCCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2198) (配列番号2211) 5'-CCTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2199) (配列番号2212) 5'-CTGGCTCGCCTBGGGCCCC-3' (フラグメント番号2200) (配列番号2213) 5'-TGGCTCGCCTBGGGCCCC-3' (フラグメント番号2201) (配列番号2214) 5'-GGCTCGCCTBGGGCCCC-3' (フラグメント番号2202) (配列番号2215) 5'-GCTCGCCTBGGGCCCC-3' (フラグメント番号2203) (配列番号2216) 5'-CTCGCCTBGGGCCCC-3' (フラグメント番号2204) (配列番号2217) 5'-TCGCCTBGGGCCCC-3' (フラグメント番号2205) (配列番号2218) 5'-CGCCTBGGGCCCC-3' (フラグメント番号2206) (配列番号2219) 5'-GCCTBGGGCCCC-3' (フラグメント番号2207) (配列番号2220) 5'-CCTBGGGCCCC-3' (フラグメント番号2208) (配列番号2221) 5'-CTBGGGCCCC-3' (フラグメント番号2209) (配列番号2222) 5'-GGGTGGGCBCGGCGGCC-3' (フラグメント番号2210) (配列番号2223) 5'-GGTCGGCGBBGBGCTCGTCGTGGC-3' (フラグメント番号2211) (配列番号2224) 5'-GGTCGGCGBBGBGCTCGTCGTGG-3' (フラグメント番号2212) (配列番号2225) 5'-GGTCGGCGBBGBGCTCGTCGTG-3' (フラグメント番号2213) (配列番号2226) 5'-GGTCGGCGBBGBGCTCGTCGT-3' (フラグメント番号2214) (配列番号2227) 5'-GGTCGGCGBBGBGCTCGTCG-3' (フラグメント番号2215) (配列番号2228) 5'-GGTCGGCGBBGBGCTCGTC-3' (フラグメント番号2216) (配列番号2229) 5'-GGTCGGCGBBGBGCTCGT-3' (フラグメント番号2217) (配列番号2230) 5'-GGTCGGCGBBGBGCTCG-3' (フラグメント番号2218) (配列番号2231) 5'-GGTCGGCGBBGBGCTC-3' (フラグメント番号2219) (配列番号2232) 5'-GGTCGGCGBBGBGCT-3' (フラグメント番号2220) (配列番号2233) 5'-GGTCGGCGBBGBGC-3' (フラグメント番号2221) (配列番号2234) 5'-GGTCGGCGBBGBG-3' (フラグメント番号2222) (配列番号2235) 5'-GGTCGGCGBBGB-3' (フラグメント番号2223) (配列番号2236) 5'-GGTCGGCGBBG-3' (フラグメント番号2224) (配列番号2237) 5'-GTCGGCGBBGBGCTCGTCGTGGC-3' (フラグメント番号2225) (配列番号2238) 5'-TCGGCGBBGBGCTCGTCGTGGC-3' (フラグメント番号2226) (配列番号2239) 5'-CGGCGBBGBGCTCGTCGTGGC-3' (フラグメント番号2227) (配列番号2240) 5'-GGCGBBGBGCTCGTCGTGGC-3' (フラグメント番号2228) (配列番号2241) 5'-GCGBBGBGCTCGTCGTGGC-3' (フラグメント番号2229) (配列番号2242) 5'-CGBBGBGCTCGTCGTGGC-3' (フラグメント番号2230) (配列番号2243) 5'-GBBGBGCTCGTCGTGGC-3' (フラグメント番号2231) (配列番号2244) 5'-BBGBGCTCGTCGTGGC-3' (フラグメント番号2232) (配列番号2245) 5'-BGBGCTCGTCGTGGC-3' (フラグメント番号2233) (配列番号2246) 5'-GBGCTCGTCGTGGC-3' (フラグメント番号2234) (配列番号2247) 5'-BGCTCGTCGTGGC-3' (フラグメント番号2235) (配列番号2248) 5'-GCTCGTCGTGGC-3' (フラグメント番号2236) (配列番号2249) 5'-CTCGTCGTGGC-3' (フラグメント番号2237) (配列番号2250) 5'-TCGTCGTGGC-3' (フラグメント番号2238) (配列番号2251) 5'-GGGGCCCCGCGCCGCCCGCC-3' (フラグメント番号2239) (配列番号2252) 5'-GGGGCCCCGCGCCGCCCGC-3' (フラグメント番号2240) (配列番号2253) 5'-GGGGCCCCGCGCCGCCCG-3' (フラグメント番号2241) (配列番号2254) 5'-GGGGCCCCGCGCCGCCC-3' (フラグメント番号2242) (配列番号2255) 5'-GGGGCCCCGCGCCGCC-3' (フラグメント番号2243) (配列番号2256) 5'-GGGGCCCCGCGCCGC-3' (フラグメント番号2244) (配列番号2257) 5'-GGGGCCCCGCGCCG-3' (フラグメント番号2245) (配列番号2258) 5'-GGGGCCCCGCGCC-3' (フラグメント番号2246) (配列番号2259) 5'-GGGGCCCCGCGC-3' (フラグメント番号2247) (配列番号2260) 5'-GGGCCCCGCGCCGCCCGCC-3' (フラグメント番号2248) (配列番号2261) 5'-GGCCCCGCGCCGCCCGCC-3' (フラグメント番号2249) (配列番号2262) 5'-GCCCCGCGCCGCCCGCC-3' (フラグメント番号2250) (配列番号2263) 5'-CCCCGCGCCGCCCGCC-3' (フラグメント番号2251) (配列番号2264) 5'-CCCGCGCCGCCCGCC-3' (フラグメント番号2252) (配列番号2265) 5'-CCGCGCCGCCCGCC-3' (フラグメント番号2253) (配列番号2266) 5'-CGCGCCGCCCGCC-3' (フラグメント番号2254) (配列番号2267) 5'-GCGCCGCCCGCC-3' (フラグメント番号2255) (配列番号2268) 5'-CGCCGCCCGCC-3' (フラグメント番号2256) (配列番号2269) 5'-GCCGCCCGCC-3' (フラグメント番号2257) (配列番号2270) 5'-GGGGCGCGCGGGGCCGCCGGG-3' (フラグメント番号2258) (配列番号2271) 5'-GGCGGGGBGCGGCBGGGCCCGGGCCC-3' (フラグメント番号2259) (配列番号2272)
5'-GGCGCGTCGCCGTCGCCCCBGTCGGGCTCGCGC-3' (フラグメント番号2260) (配列番号
2273) 5'-GCGCGGGCBBCBGCGBGCCGGGCGCG-3' (フラグメント番号2261) (配列番号2274)
5'-GCGCBCGGGCCCBCCTGCGCGGGC-3' (フラグメント番号2262) (配列番号2275) 5'-GGGCGGGGTGGGCTGCCCTGCGGCCGCC-3' (フラグメント番号2263) (配列番号2276)
5'-GGGCTGCTGCGCGGCGGCTCCGGCGA-3' (フラグメント番号2264) (配列番号2277)
5'-CTCCCGGGCGGGGCCGGGCGCGGGG-3' (フラグメント番号2265) (配列番号2278) 5'-GGGCTGCCGCGGTCCGGGCCCCTCTTGCCGGCG-3' (フラグメント番号2266) (配列番号
2279) 5'-GCGCTCGCGCCGCTGCCGG-3' (フラグメント番号2267) (配列番号2280) 5'-GCGCCGCTTGGCCTTGTCGCGGC-3' (フラグメント番号2268) (配列番号2281) 5'-GCTGCTCCBCGCGCTGG-3' (フラグメント番号2269) (配列番号2282) 5'-GCCGGBGGCCGGCCBGGTCCCGCG-3' (フラグメント番号2270) (配列番号2283) 5'-CCCGGCGGCCGGCBGGBBGGGCGGGCTGGGC-3' (フラグメント番号2271) (配列番号22
84) 5'-GTCTCTCCCGCCCCGGCCGCGCG-3' (フラグメント番号2272) (配列番号2285) 5'-GGGCGTCCGCTCCGGGCCGTCGGG-3' (フラグメント番号2273) (配列番号2286) 5'-GCGGGCACGCGGCGGCTCTGGCGTCGGC-3' (フラグメント番号2274) (配列番号2287) ブラジキニンレセプター核酸およびアンチセンスオリゴヌクレオチドフラグメ ント 5'-GGTGBCBTTG BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC CCAGCCACTC CAC
TTGGGGG CGGGTGGCCA GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGAAGG GCAGCCCGC
A GGCCAGGATC AGGTCTGCTG CGGCCGGAGA TAATGGCATT CACCACGCGG CGGCCCAGCG CACG
CCGCGC ATCCGGCCCG GGTTCTGACC TGCAGCCCCC GTCTCCTTGG CATTCCTGGG CCCCAGTCAC
TCCTCTCCCT GCCCCCCTTG CTGGGGCAGG GACGGGGTG BCBTTGBGCB TGTCGGCGCG GTCCCG
TTBB GBGTGGGCCC GCCAGCCCAG CCACTCCACT TGGGGGCGGG TGGCCAGCAC GAACAGCACC C
AGAGGAAGG GGGGCGGCCC AGAAGGGCAG CCCGCAGGCC AGGATCAGGT CTGCTGCGGC CGGAGAT
AAT GGCATTCACC ACGCGGCGGC CCAGCGCACG CCGCGCATCC GGCCCGGGTT CTGACCTGCA GC
CCCCGTCT CCTTGGCATT CCTGGGCCCC AGTCACTCCT CTCCCTGCCC CCCTTGCTGG GGCAGGGA
CG GCCGTGTTGT CBGTGGTGCT GCCCGTTTGB GGTBTGGCGC TCCBCCBBTT CCCTTTTCTC CTT
GTTTTCC GTTTCTCTTG CCGTCTGTGG TT CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGA
CAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC A
GCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGG
TAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GG
TGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACAC
CT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGC
TTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCAT
C CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCA
GCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA
ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAA
TCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG
AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGC
CACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA A
GGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCC
CTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AA
GCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAG
GA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGT
GTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCA
C CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTG
ATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC
CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCT
CAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA
GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACT
TGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC T
AGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGA
ACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AA
GGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTA
GA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AAC
CTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGA
A GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAG
CTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA
CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACC
AATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC
TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAG
AAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT G
AAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATG
GTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TG
AGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACA
TC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGA
GAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAA
A AAAAAAAAA AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGC
CGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT
CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTA
GCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT T
GAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAG
AGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CA
CCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTC
CT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTT
GCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAAT
T ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGA
ACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT
GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACA
CACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC
ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAG
TCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA C
CAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGG
ATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AA
AAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAAT
TG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAA
GTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCT
G CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCC
CTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC
CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATC
CATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC
AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTG
CAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC T
GAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATC
AAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TG
CTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTC
CA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACG
TCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCA
A TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTC
ACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG
ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGG
AGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA
AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCT
TGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT C
CTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATT
AAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AA
CACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGA
GG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAA
ACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAG
C AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCA
GGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT
ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCT
CATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA
ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAG
GAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA A
GATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTG
GGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TC
ACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTT
AT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCC
AGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGA
A AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTA
AGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC
CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCT
TCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC
CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAG
CCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG G
CCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAG
GGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GG
TCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAA
TC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTG
ACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGA
A AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTC
TTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC
CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGC
TAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA
ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGT
GGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA A
ATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGAT
CCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TC
AAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCA
GT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTG
CTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGC
A GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTC
TCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG
GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAG
GGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC
CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAG
GGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC T
TGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACC
GCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AG
GGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCA
AC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTC
CTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCC
G CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGA
CTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG
CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGG
GCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC
CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACC
GCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG T
GGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAA
CAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TG
TGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATC
GC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCC
TTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGA
A AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCA
GATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA
GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATT
GAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG
AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAG
CATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC T
GTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCA
GGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AG
ATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTG
GG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCC
CTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGA
G GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGC
ACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT
GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTG
GGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT
CCTGCCTC GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAG
GA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGA
AGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCT
C TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTT
TCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATA
GGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT
CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGG
TGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT
TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCT
CCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA A
GAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCC
ACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CC
CTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTC
TT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCC
GAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGC
C ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCT
GGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA
TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACAT
GGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG
GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGG
TGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT G
GGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACC
CAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GG
GTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCC
CA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCT
GGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTG
T GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA
CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAG
GGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA
TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCAT
GGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT T
CTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGG
AGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TC
TCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGT
TT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTG
AGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGT
C TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACT
GTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG
AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGT
GATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT
GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTA
TAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG G
GATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATT
GGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CC
ACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCC
AT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGG
ATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCA
G GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGG
CCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG
GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGC
TAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG
AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGG
AGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG C
TAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAA
CCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TG
GCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGG
GC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAG
AACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAG
C CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTC
CTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA
AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTG
CCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG
CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGG
ATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG A
TGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCA
TTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TG
AGGTTTTT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAA
A ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGG
GTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC
AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGA
GACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC
CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCA
AACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG G
AAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGT
GCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA AC
CTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTG
TG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGG
CTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGC
T ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTC
ACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC
TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGAC
TGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC
CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAAT
GGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC T
TGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTC
CCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CC
TCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATT
CT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTT
CTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCC
C TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTC
TGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC
CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACC
AAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA
CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCT
CTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG A
GCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGG
GAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AG
AATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCC
AG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTT
TCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCA
G TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGC
CCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA
GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGA
GGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG
GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGA
AACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT T
TAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGG
ACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TG
CCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCC
AA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAG
GATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGT
C TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTT
TTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC
AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAG
CTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC
CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGG
CTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA A
GATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGA
AGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TA
ATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCA
TC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGC
TTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCA
G AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACT
TGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA
ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCA
CCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT
TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGA
AGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA C
GGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTC
TTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC AC
AGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTG
TG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATT
CAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTG
C CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTA
GAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA
TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTG
ATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT
TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGT
GAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC A
GCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCC
TCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AG
GAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGG
AA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAG
TTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAG
C TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGA
AATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG
GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTC
CACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT
GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTC
AATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG A
GTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCT
AGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CT
ACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCA
TC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCC
ATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTG
A AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTG
GGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA
GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACA
TGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC
ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACG
GTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT T
CCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAAT
CAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CG
TGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCA
GG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGC
CAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTG
A ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATC
TATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC
CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAA
TCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG
GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCC
CAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC A
AGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCAT
TAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CC
TCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGT
AT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGG
AACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGT
C GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACT
ATTGCA CACCACCTGT CCTGCCTC CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG C
CCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTG
AGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GC
CCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACA
CC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTC
AGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCA
G CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTG
GCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT
CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCC
GGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG
AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCT
TGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG G
CTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAA
CGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GC
TGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCC
TC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTC
ATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAG
A AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGAT
GGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA
CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAG
GGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA
TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCAT
GGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT T
CTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGG
AGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TC
TCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGT
TT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTG
AGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGG
T CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCAC
TGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG
GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGT
GATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT
GTCCCTGCCT CAGTTCCCTC TTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTA
TAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG G
GATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTT
TT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACG
GCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTC
C CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATG
CCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG
AATCTCCAGG TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCT
TTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT
CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTG
GATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA T
CAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCT
GAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CA
GTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACA
TG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAA
GTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCC
A CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGA
GATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT
CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTA
TCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC
CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTG
ATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA G
CGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCAC
CAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GC
AGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGG
CC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGC
ACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGAT
G TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGT
GATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG
CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGG
AACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT
GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAG
ACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC C
TGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGAC
TCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CC
AGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCC
CT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAG
TGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCT
T GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGG
CTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC
TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTG
TTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AA
GGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTC
AA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGT
CCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGC
C GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCG
ACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA
GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATG
GGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT
CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCAC
CGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC G
TGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGA
ACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TT
GTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCAT
CG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTC
CTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCG
A AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTC
AGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC
AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGAT
TGAGG GACAGTTGCT T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACT
C CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTT
AACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG
CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTT
CTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC
TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTG
GGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT C
CTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGC
GGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CC
CATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCAT
CA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGC
TGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGC
A GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTA
TTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC
CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTA
CAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT
GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACT
CCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC A
GGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTT
GCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA
GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCC
GCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG G
ACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCG
TGG GGAGTT GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCG
AGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC T
GAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCAC
CTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AG
TTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CA
TAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGAC
CT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCA
GGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAG
T TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGT
CTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA
AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGC
CCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT
CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAG
TCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC T
CCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCT
GCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC AC
CTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAA
AA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CAC
ATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAAC
G GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAG
GGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT
GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTA
CCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG
GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTG
CCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT G
CTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCC
TGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAG
GA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTG
AGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAA
A TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGC
ATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT
TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAG
GGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA
TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGG
GTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC C
TGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAG
GTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CA
CTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTG
GG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGG
GTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACC
T GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGG
TATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG
GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTA
TTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT
CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGG
CCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG A
GGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCT
CAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GT
GGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCA
GG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGA
GCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTA
G AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCT
GGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG
CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAG
AACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC
TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAA
GGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC T
AGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAG
AGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CC
TCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAG
GA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTG
TGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCA
G CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGG
GGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG
ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAG
CATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA
TGAGGTTTTT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTT
AAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GC
GGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTA
CC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCT
GAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACT
C CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTT
CAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG
GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGC
GTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA
ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAG
TGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT G
GGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTG
GCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC AC
TCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTAT
CC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGG
ACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGC
C CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGA
ATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC
TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTC
TCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT
CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAA
TTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC T
TTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGC
CCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CC
TCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCT
TC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACA
CCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTC
A CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATG
CTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG
AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGT
GGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG
AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGC
CCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT G
TTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCT
CAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC AT
GCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCC
AA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGG
GAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAG
G GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTG
GAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT
TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGG
GGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC
TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTT
CCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC C
AGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTG
GTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GG
TTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCT
TC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GAC
AGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAG
C CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGT
GGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA
AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAA
GAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG
TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATAC
CATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA C
GCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTC
CAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CA
CTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTC
CA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGG
CACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCT
T TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATA
GAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA
CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGC
TCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC
ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAG
TGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG A
TTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATT
TGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GG
TAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAG
AA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CAC
TGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATT
T TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAG
GTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC
AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTAT
CCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC
AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCT
GGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA A
AGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGA
AGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AG
GAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGG
GG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGC
TCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTT
T GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGC
TCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG
AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACC
CTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT
CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCAC
CATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC T
CCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGG
TGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TC
TGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGAT
GA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAA
CATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGAT
C ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCA
CGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT
TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTA
ATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT
CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTG
CAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA C
GCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTG
TGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CA
TCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCT
GC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAA
AATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGT
G GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGC
CCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC
AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGC
ATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC
CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCT
GTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA A
GGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACG
GTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TA
CTATTGCA CACCACCTGT CCTGCCTC TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA
CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAA
GGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT
GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTC
CAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG T
CTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCA
AAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CG
GAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAA
TA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTC
TGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTC
G GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTT
CCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA
CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTG
GGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA
CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGG
GAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC A
ACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACC
TGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CC
ATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGT
AC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCA
CAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCT
G AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGG
TGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG
TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGAT
ACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA
GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAA
GCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA G
AACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTC
ACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TG
TGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCAC
GA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAA
TTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACA
A CAGCATTACT GTTCTTATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGA
GGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA
GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAG
TTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA
AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTG
ATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG T
ATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACT
C CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTT
AACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG
CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTT
CTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC
TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTG
GGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT C
CTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGC
GGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CC
CATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCAT
CA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGC
TGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGC
A GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTA
TTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC
CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTA
CAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT
GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACT
CCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC A
GGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTT
GCT T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC
ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTT
GCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC T
CTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAA
GAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CT
GCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCT
GC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTG
AGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGG
G CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTT
CCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC
CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTG
TCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG
GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGC
TGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT G
CCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTG
CCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CC
AGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACAC
TG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAG
TGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTC
AAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CG
GTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGA
GA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCC
AGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GC
CCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGG
GA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATG
CCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAG
G ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGT
CGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAG
CACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA
CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATG
AGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA
GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGAT
GGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG A
TGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCT
GTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TC
CAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAA
AC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGG
CCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCC
C TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTC
TGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC
AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCC
AGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG
CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCG
GAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT G
CAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCA
AAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GG
TGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTT
GC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAA
ACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGG
G AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG -3' (フラグメント番号2275) (配列
番号3018) 5'- GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CA
CACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAG
TC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACC
ACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCT
A GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAG
GCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG
GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTT
CTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT
ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAA
AGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG T
CTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAG
CCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CA
CCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGAT
AA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACT
TTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAA
A CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGA
AGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA
GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAG
CTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG
GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGA
GAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC C
AGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGG
AAA AGTTCCCTTC CTTCCGGAGG GAGG-3' (フラグメント番号2275) (配列番号2461)
5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GG
GGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGC
CC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGC
TGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCT
G TGGTCGTGGG GAGTT -3' (フラグメント番号2275) (配列番号2460) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GG
GGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGC
TT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GAC
AAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTG
G GGAGTT-3' (フラグメント番号2275)(配列番号2459) 5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC AC
GGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGC
CC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCT
GGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGA
G CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGC
GGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC
CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAG
CATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG
CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCC
GGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC C
CTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTC
ATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GA
GATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTG
GC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCC
AGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCC
T CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAG
GGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG
CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTG
AGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (フラ
グメント番号2275) (配列番号2458) 5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC AC
GGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGC
CC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCT
GGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGA
G CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGC
GGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC
CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAG
CATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG
CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCC
GGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC C
CTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTC
ATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GA
GATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTG
GC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCC
AGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCC
T CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAG
GGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG
CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTG
AGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (フラ
グメント番号2275) (配列番号2457) 5'- TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CA
AGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGT
AG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTG
CTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGA
T GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCT
TTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG
GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGT
CCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA
AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGT
GCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG G
TTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACA
GCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AA
CGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCC
CC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCT
GCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGA
T CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGG
GAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG
ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGG
CGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA
TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCA
GCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT G
CCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAG
AAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TT
CATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCT
CT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACA
GCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGG
A GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCC
ATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG
AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGC
TTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA
TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGA
GGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT G
CTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTG
ACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GA
ACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAAT
CT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCT
TGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAA
A GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA -3' (
フラグメント番号2275) (配列番号2456) 5'- CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CC
CCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCC
AC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTG
CCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCT
G GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAG
AGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC
GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTG
CCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA
GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGG
CCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT C
CGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCC
CTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GT
CATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGA
GA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCT
GGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCC
A GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGC
CTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG
GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACT
GCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT
GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATG
GGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA A
ACACCGGAG ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAAC
TCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GA
GCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCC
TC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAG
CTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAG
A ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCT
GGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA
ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAG
AGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC
ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGG
AGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC T
TCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAA
GGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AA
AGACACTG AGGTCTAGA -3' (フラグメント番号2275) (配列番号2455) 5'- AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GC
AGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTT
CG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGC
ATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGG
G AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACT
CCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT
GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCC
TCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG
TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCC
CACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC C
GTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGT
GTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC AC
CCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCA
CA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGA
ATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCAT
C TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAG
TGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC
CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAG
CCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC
AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGAC
CCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA C
AGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCT
CTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CC
AATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCA
TC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCT
GACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATC
C TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATC
CACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT
TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGA
CTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG
AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCA
GCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC C
ACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGT
GCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GG
CAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCA
TG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGC
AGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGT
T ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAA
ATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC
TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTG
AGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC
TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGG
CCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC T
TTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCT
TGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AA
GATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTT
GA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTG
CAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTG
G GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAG
AGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG
GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCT
AGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA
GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCAC
CACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC A
GGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGC
TAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AG
TTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAA
AT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTC
TCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTT
G TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAG
CTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG
TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGA
GGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA
GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCC
CAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC T
TGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTC
CAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GT
GGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCT
AG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAA
AGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAAT
T ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATG
ACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT
TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGAC
TATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT
GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGG
CTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT A
ATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCC
CCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AA
CACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGAT
GA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTC
AGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGG
C TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGG
GGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT
CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCAT
CCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG
TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAG
ACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT C
TTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGT
TTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG AT
GCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTC
AC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTG
TCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCC
T GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAG
ATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG
CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGG
CATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG
CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGT
CTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA G
AACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGG
GCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG AC
AGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGT
TG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCT
GTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTAT
T TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAG
GAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG
GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCT
TTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG
GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGT
GCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA G
GCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACG
ACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TA
TGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC
-3' (フラグメント番号2275) (配列番号2454) 5'- CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GC
TGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGAC
AT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCC
CTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCA
A AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGA
GTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG
CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGC
ACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT
GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTC
CCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT G
CTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGA
AGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GA
CGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACC
AA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTG
AGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGC
A TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAG
CTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT
AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACA
CAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT
TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAA
GGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC A
ATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGG
TGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GT
TGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGA
GG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTA
GAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCT
G GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAG
GGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA
GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAAC
CTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG
CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATG
AGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA A
AGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTC
TGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AG
TATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTT
GT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGC
TCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGA
G CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGC
TGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC
TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA -3' (フラグメント
番号2275) (配列番号2453) 5'- GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CA
CACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAG
TC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACC
ACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCT
A GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAG
GCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG
GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTT
CTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT
ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAA
AGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG T
CTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAG
CCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CA
CCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGAT
AA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACT
TTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAA
A CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGA
AGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA
GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAG
CTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG
GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGA
GAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC C
AGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGG
AAA AGTTCCCTTC CTTCCGGAGG GAGG-3' (FRAG..NO:2275) (配列番号2452) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GG
GGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGC
CC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGC
TGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCT
G TGGTCGTGGG GAGTT -3' (フラグメント番号2275) (配列番号2451) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GG
GGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGC
TT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GAC
AAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTG
G GGAGTT-3' (フラグメント番号2275) (配列番号2450) 5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC AC
GGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGC
CC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCT
GGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGA
G CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGC
GGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC
CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAG
CATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG
CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCC
GGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC C
CTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTC
ATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GA
GATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTG
GC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCC
AGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCC
T CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAG
GGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG
CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTG
AGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (フラ
グメント番号2275) (配列番号2449) 5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC AC
GGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGC
CC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCT
GGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGA
G CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGC
GGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC
CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAG
CATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG
CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCC
GGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC C
CTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTC
ATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GA
GATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTG
GC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCC
AGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCC
T CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAG
GGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG
CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTG
AGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (フラ
グメント番号2275) (配列番号2448) 5'- TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CA
AGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGT
AG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTG
CTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGA
T GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCT
TTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG
GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGT
CCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA
AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGT
GCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG G
TTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACA
GCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AA
CGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCC
CC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCT
GCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGA
T CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGG
GAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG
ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGG
CGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA
TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCA
GCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT G
CCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAG
AAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TT
CATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCT
CT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACA
GCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGG
A GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCC
ATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG
AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGC
TTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA
TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGA
GGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT G
CTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTG
ACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GA
ACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAAT
CT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCT
TGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAA
A GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA -3' (
フラグメント番号2275) (配列番号2447) 5'- CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CC
CCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCC
AC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTG
CCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCT
G GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAG
AGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC
GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTG
CCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA
GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGG
CCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT C
CGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCC
CTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GT
CATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGA
GA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCT
GGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCC
A GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGC
CTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG
GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACT
GCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT
GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATG
GGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA A
ACACCGGAG ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAAC
TCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GA
GCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCC
TC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAG
CTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAG
A ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCT
GGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA
ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAG
AGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC
ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGG
AGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC T
TCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAA
GGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AA
AGACACTG AGGTCTAGA -3' (フラグメント番号2275) (配列番号2446) 5'- AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GC
AGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTT
CG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGC
ATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGG
G AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACT
CCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT
GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCC
TCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG
TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCC
CACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC C
GTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGT
GTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC AC
CCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCA
CA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGA
ATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCAT
C TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAG
TGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC
CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAG
CCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC
AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGAC
CCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA C
AGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCT
CTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CC
AATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCA
TC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCT
GACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATC
C TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATC
CACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT
TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGA
CTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG
AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCA
GCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC C
ACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGT
GCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GG
CAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCA
TG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGC
AGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGT
T ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAA
ATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC
TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTG
AGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC
TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGG
CCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC T
TTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCT
TGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AA
GATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTT
GA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTG
CAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTG
G GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAG
AGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG
GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCT
AGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA
GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCAC
CACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC A
GGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGC
TAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AG
TTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAA
AT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTC
TCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTT
G TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAG
CTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG
TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGA
GGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA
GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCC
CAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC T
TGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTC
CAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GT
GGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCT
AG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAA
AGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAAT
T ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATG
ACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT
TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGAC
TATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT
GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGG
CTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT A
ATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCC
CCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AA
CACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGAT
GA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTC
AGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGG
C TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGG
GGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT
CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCAT
CCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG
TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAG
ACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT C
TTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGT
TTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG AT
GCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTC
AC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTG
TCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCC
T GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAG
ATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG
CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGG
CATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG
CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGT
CTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA G
AACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGG
GCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG AC
AGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGT
TG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCT
GTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTAT
T TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAG
GAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG
GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCT
TTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG
GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGT
GCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA G
GCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACG
ACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TA
TGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC
-3' (フラグメント番号2275) (配列番号2445) 5'-CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCT
GTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACA
T CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCC
TGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA
AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAG
TGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG
CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCA
CAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT G
CATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCC
CCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GC
TGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAA
GG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GAC
GGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCA
A TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGA
GGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA
TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGC
TCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT
AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACAC
AGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT T
TCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAG
GGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AA
TCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGT
GT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTT
GGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAG
G CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAG
AAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG
GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGG
GCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA
GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACC
TGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG C
AGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGA
GAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AA
GCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCT
GC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGT
ATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTG
T CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCT
CTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG
CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCT
GTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC
TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA-3' (フラグメント番
号2275) (配列番号2444) 5'- GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CA
CACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAG
TC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACC
ACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCT
A GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAG
GCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG
GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTT
CTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT
ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAA
AGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG T
CTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAG
CCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CA
CCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGAT
AA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACT
TTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAA
A CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGA
AGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA
GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAG
CTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG
GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGA
GAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC C
AGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGG
AAA AGTTCCCTTC CTTCCGGAGG GAGG-3' (フラグメント番号2275) (配列番号2443)
5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GG
GGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGC
CC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGC
TGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCT
G TGGTCGTGGG GAGTT -3' (フラグメント番号2275) (配列番号2442) 5'- AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GC
AGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTT
CG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGC
ATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGG
G AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACT
CCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT
GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCC
TCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG
TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCC
CACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC C
GTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGT
GTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC AC
CCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCA
CA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGA
ATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCAT
C TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAG
TGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC
CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAG
CCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC
AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGAC
CCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA C
AGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCT
CTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CC
AATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCA
TC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCT
GACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATC
C TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATC
CACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT
TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGA
CTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG
AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCA
GCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC C
ACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGT
GCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GG
CAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCA
TG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGC
AGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGT
T ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAA
ATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC
TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTG
AGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC
TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGG
CCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC T
TTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCT
TGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AA
GATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTT
GA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTG
CAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTG
G GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAG
AGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG
GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCT
AGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA
GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCAC
CACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC A
GGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGC
TAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AG
TTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAA
AT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTC
TCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTT
G TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAG
CTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG
TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGA
GGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA
GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCC
CAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC T
TGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTC
CAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GT
GGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCT
AG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAA
AGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAAT
T ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATG
ACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT
TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGAC
TATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT
GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGG
CTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT A
ATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCC
CCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AA
CACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGAT
GA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTC
AGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGG
C TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGG
GGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT
CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCAT
CCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG
TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAG
ACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT C
TTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGT
TTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG AT
GCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTC
AC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTG
TCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCC
T GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAG
ATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG
CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGG
CATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG
CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGT
CTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA G
AACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGG
GCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG AC
AGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGT
TG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCT
GTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTAT
T TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAG
GAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG
GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCT
TTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG
GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGT
GCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA G
GCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACG
ACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TA
TGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC
-3' (FRAQ. NO: ) (配列番号2441) 5'-CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCT
GTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACA
T CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCC
TGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA
AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAG
TGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG
CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCA
CAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT G
CATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCC
CCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GC
TGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAA
GG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GAC
GGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCA
A TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGA
GGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA
TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGC
TCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT
AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACAC
AGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT T
TCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAG
GGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AA
TCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGT
GT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTT
GGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAG
G CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAG
AAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG
GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGG
GCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA
GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACC
TGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG C
AGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGA
GAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AA
GCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCT
GC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGT
ATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTG
T CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCT
CTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG
CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCT
GTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC
TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA -3' (FRAQ. NO: ) (
配列番号2431) 5'-GGTGBCBTTGBGCBTGTCGGCGC-3' (フラグメント番号2276) (配列番号2289) 5'-GGTCCCGTTBBGBGTGGGCCC-3' (フラグメント番号2277) (配列番号2290) 5'-GCCAGCCCAGCCACTCCACTTGGGGGC-3' (フラグメント番号2278) (配列番号2291)
5'-GGGTGGCCAGCACGAACAGCACCCAGAGGAAGGGGGGC-3' (フラグメント番号2279) (配
列番号2292) 5'-GGCCCAGAAGGGCAGCCCGCAGGCCAGGATCAGGTCTGCTGCGGCC-3'(フラグメント番号228
0)(配列番号2293) 5'-GGAGATAATGGCATTCACCACGCGGC-3' (フラグメント番号2281) (配列番号2294)
5'-GGCCCAGCGCACGCCGCGCATCCGGCCC-3' (フラグメント番号2282) (配列番号2295)
5'-GGGTTCTGACCTGCAGCCCCC-3' (フラグメント番号2283) (配列番号2296) 5'-GTCTCCTTGGCATTCCTGGGCCC-3' (フラグメント番号2284) (配列番号2297) 5'-CAGTCACTCCTCTCCCTGCCCCC-3' (フラグメント番号2285) (配列番号2298) 5'-CTTGCTGGGGCAGGGACGG-3' (フラグメント番号2286) (配列番号2299) 5'-GGTGBCBTTGBGCBTGTCGGCGC-3' (フラグメント番号2287) (配列番号2300) 5'-GGTCCCGTTBBGBGTGGGCCC-3' (フラグメント番号2288) (配列番号2301) 5'-GCCAGCCCAGCCACTCCACTTGGGGGC-3' (フラグメント番号2289) (配列番号2302)
5'-GGGTGGCCAGCACGAACAGCACCCAGAGGAAGGGGGGC-3' (フラグメント番号2290) (配
列番号2303) 5'-GGCCCAGAAGGGCAGCCCGCAGGCCAGGATCAGGTCTGCTGCGGCC-3'(フラグメント番号229
1)(配列番号2304) 5'-GGAGATAATGGCATTCACCACGCGGC-3' (フラグメント番号2292) (配列番号2305)
5'-GGCCCAGCGCACGCCGCGCATCCGGCCC-3' (フラグメント番号2293) (配列番号2306)
5'-GGGTTCTGACCTGCAGCCCCC-3' (フラグメント番号2294) (配列番号2307) 5'-GTCTCCTTGGCATTCCTGGGCCC-3' (フラグメント番号2295) (配列番号2308) 5'-CAGTCACTCCTCTCCCTGCCCCC-3' (フラグメント番号2296) (配列番号2309) 5'-CTTGCTGGGGCAGGGACGG-3' (フラグメント番号2297) (配列番号2310) 5'-CCGTGTTGTCBGTGGTGCTG-3' (フラグメント番号2298) (配列番号2311) 5'-CCCGTTTGBGGTBTGGC-3' (フラグメント番号2299) (配列番号2312) 5'-GCTCCBCCBBTTCCCTTTTCTCC-3' (フラグメント番号2300) (配列番号2313) 5'-TTGTTTTCCGTTTCTCTTG-3' (フラグメント番号2301) (配列番号2314) 5'-CCGTCTGTGGTT-3' (フラグメント番号2302) (配列番号2315) β2アドレナリン様(Adrenergic)レセプターキナーゼ核酸およびアンチセンス
オリゴヌクレオチドフラグメント 5'- GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GC
CATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAG
CA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TTT
CCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCT
T GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCC
CGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG
AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCA
GCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG
ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACT
TCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA C
ACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACC
CTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TG
CATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGA
CC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCG
AGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCA
A CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT CTCC
AAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC
GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGG
GCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA
TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGA
GGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT T
TTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGA
GGG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA AT
CAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCA
GC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCA
AGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGC
A TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTG
TTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG
ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGG
GAAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG
ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGC
CCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC C
CACCCGCCT CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGA
GGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GG
GTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCA
AG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC TTTGGGCAGA GTG
TGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGCT
T CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGG
CCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCTCAG
GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTT
GGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA
GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAG
CCTA GAGGTGCACA GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA T
GGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAG
AGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA CT
CTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGC
TG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGT
ACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGG
G TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAG
GGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG
ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTC
CACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC
CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAG
TAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG G
TGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTC
TCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TG
CGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAG
AG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGC
GGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGG
G TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGA
GGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC
AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGG
GGCCG GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC
AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCC
GCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC C
GAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGG
CGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TG
AGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTG
CT GCCCGAGCCC AGGTGAGGAG AAGCT-3' (フラグメント番号 ) (配列番号2430)
5'-CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA AGG
TACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTT
G GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCT
CCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC TTTGGGCAGA GTGTGGTGAG
TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGCTT CTGGG
TGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA
TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCC
AGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT A
AAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAAC
CTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GA
GGTGCACA GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATG
AG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAGAGA GGC
TCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA CTCTGGGTG
G CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAG
AGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA
AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGG
TGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG
GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTAC
TAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG T
TCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCC
CAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CA
GGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGT
CG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGT
GGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAA
G GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCT
GAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA
CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTC
TTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC
GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGG
CGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG G
AGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCG
GCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GT
GAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCG
AG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGG
CGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACC
T GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCC
GAGCCC AGGTGAGGAG AAGCT-3' (フラグメント番号 ) (配列番号2429) 5'-GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCC
ATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGC
A TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TTTC
CCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT
GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCC
GCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG
AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAG
CCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG A
TAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTT
CAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CA
CAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCC
TG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGC
ATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGAC
C TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGA
GATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCAA
CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT CTCCA
AGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC
GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGG
CACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA T
GGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAG
GGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TT
TCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAG
GG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATC
AAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAG
C AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAA
GAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA
TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTGT
TCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG
ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGG
AAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG A
CGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCC
CGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CC
ACCCGCCT-3' (フラグメント番号 ) (配列番号2428) CCR-2 CCケモカインレセプター核酸およびアンチセンスオリゴヌクレオチドフ ラグメント 5'-CTTTGTGAAG AAGGAATTGG CAACACTGAA ACCTCCAGAA CAAAGGCTGT CACTAAGGTC CCG
CTGCCTT GATGGATTAT ACACTTGACC TCAGTGTGAC AACAGTGACC GACTACTACT ACCCTGATA
T CTTCTCAAGC CCCTGTGATG CGGAACTTAT TCAGACAAAT GGCAAGTTGC TCCTTGCTGT CTTT
TATTGC CTCCTGTTTG TATTCAGTCT TCTGGGAAAC AGCCTGGTCA TCCTGGTCCT TGTGGTCTGC
AAGAAGCTGA GGAGCATCAC AGATGTATAC CTCTTGAACC TGGCCCTGTC TGACCTGCTT TTTGT
CTTCT CCTTCCCCTT TCAGACCTAC TATCTGCTGG ACCAGTGGGT GTTTGGGACT GTAATGTGCA
AAGTGGTGTC TGGCTTTTAT TACATTGGCT TCTACAGCAG CATGTTTTTC ATCACCCTCA TGAGTG
TGGA CAGGTACCTG GCTGTTGTCC ATGCCGTGTA TGCCCTAAAG GTGAGGACGA TCAGGATGGG C
ACAACGCTG TGCCTGGCAG TATGGCTAAC CGCCATTATG GCTACCATCC CATTGCTAGT GTTTTAC
CAA GTGGCCTCTG AAGATGGTGT TCTACAGTGT TATTCATTTT ACAATCAACA GACTTTGAAG TG
GAAGATCT TCACCAACTT CAAAATGAAC ATTTTAGGCT TGTTGATCCC ATTCACCATC TTTATGTT
CT GCTACATTAA AATCCTGCAC CAGCTGAAGA GGTGTCAAAA CCACAACAAG ACCAAGGCCA TCA
GGTTGGT GCTCATTGTG GTCATTGCAT CTTTACTTTT CTGGGTCCCA TTCAACGTGG TTCTTTTCC
T CACTTCCTTG CACAGTATGC ACATCTTGGA TGGATGTAGC ATAAGCCAAC AGCTGACTTA TGCC
ACCCAT GTCACAGAAA TCATTTCCTT TACTCACTGC TGTGTGAACC CTGTTATCTA TGCTTTTGTT
GGGGAGAAGT TCAAGAAACA CCTCTCAGAA ATATTTCAGA AAAGTTGCAG CCAAATCTTC AACTA
CCTAG GAAGACAAAT GCCTAGGGAG AGCTGTGAAA AGTCATCATC CTGCCAGCAG CACTCCTCCC
GTTCCTCCAG CGTAGACTAC ATTTTGTGAG GATCAATGAA GACTAAATAT AAAAAACATT TTCTTG
AATG GCATGCTAGT AGCAGTGAGC AAAGGTGTGG GTGTGAAAGG TTTCCAAAAA AAGTTCAGCA T
GAAGGATGC CGTGTGTGTT GTTGCCAACA CTTGGAACAC AATGACTGGA GACATAGTTG TGCATGC
CTG GCACAACATC AAGCCTGTGA TTGTGTTTAT TGATGATGTT GAACAAGTGG TGGCTTTGAG GG
ATTCTGTA TGCCAAGTGG AAAAAAAAGA TGTCTCCGGA ATTCGACAGG TTATCA-3' (フラグメ
ント番号 ) (配列番号2462) CCR-4 CCケモカインレセプター核酸およびアンチセンスオリゴヌクレオチドフ ラグメント 5'-TTTCATCTCT CCGGGCTTAT TTGCTGGTTT CTCCGAATGC GGGCCTTGTC TGGTTCACGC TGG
ATCCCCA ACGCCTAGAA CAGTGCGTGG CACGCAGTTC GTCCTTCTAT AAATATCGGA CTAAATGCA
T CTCTGTGATG GTAATACCCA CACGGTGTTG TGAGAATGAA TGAGTGATTC TGTGCAAGTT CCTA
GTGATC TGTTACAAAA AGTACTGGTC GCTAAATTAC TCTTATAATA AAGCATACTT TTAGGATAAT
AAAGCACTAT TCGCGAATTG GTTACCGCTA TTATGAAATT ACTGAGCAAT ACATATCTAC ATCTG
ATCAG TCTCCAGAAT TATGCCAAAT CCTACCTTCT TCTGAAAGTA TCTCCTAATT ATCTGCACCT
GACCCTAGTG ATGCTGTGAA TGTGCAAGTA TAGCTACATC CTCCGAAGGA AGGATCTTTA CTCCTT
TTAC CTCCTGAATG GGCTGCGTCT GCTGAAAGCG CGGGGGAATG GGCGGTTGGA AGCTTGGCCC T
ACTTCCAGC ATTGCCGCCT ACTGGTTGGG TTACTCCAGC AAGTCACTCC CCTTCCCTGG GCCTCAG
TGT CTCTACTGTA GCATTCCCAG GTCTGGAATT CCATCCACTT TAGCAAGGAT GGACGCGCCA CA
GAGAGACG CGTTCCTAGC CCGCGCTTCC CACCTGTCTT CAGGCGCATC CCGCTTCCCT CAAACTTA
GG AAATGCCTCT GGGAGGTCCT GTCCGGCTCC GGACTCACTA CCGACCACCC GCAAACAGCA GGG
TCCCCTG GGCTTCCCAA GCCGCGCACC TCTCCGCCCC GCCCCTGCGC CCTCCTTCCT CGCGTCTGC
C CCTCTCCCCC ACCCCGCCTT CTCCCTCCCC GCCCCAGCGG CGCATGCGCC GCGCTCGGAG CGTG
TTTTTA TAAAAGTCCG GCCGCGGCCA GAAACTTCAG TTTGTTGGCT GCGGCAGCAG GTAGCAAAGT
GACGCCGAGG GCCTGAGTGC TCCAGTAGCC ACCGCATCTG GAGAACCAGC GGTTACCATG GAGGG
GATCA GTGTAAGTCC AGTTTCAACC TGCTTTGTCA TAAATGTACA AACGTTTGAA CTTAGAGCGC
AGCCCCTCTC CGAGCGGGCA GAAGCGGCCA GGACATTGGA GGTACCCGTA CTCCAAAAAA GGGTCA
CCGA AAGGAGTTTT CTTGACCATG CCTATATAGT GCGGGTGGGT GGGGGGGGAG CAGGATTGGA A
TCTTTTTCT CTGTGAGTCG AGGAGAAACG ACTGGAAAGA GCGTTCCAGT GGCTGCATGT GTCTCCC
CCT TGAGTCCCGC CGCGCGCGGC GGCTTGCACG CTGTTTGCAA ACGTAAGAAC ATTCTGTGCA CA
AGTGCAGA GAAGGCGTGC GCGCTGCCTC GGGACTCAGA CCACCGGTCT CTTCCTTGGG GAAGCGGG
GA TGTCTTGGAG CGAGTTACAT TGTCTGAATT TAGAGGCGGA GGGCGGCGTG CCTGGGCTGA CTT
CCCAGGA GGAGATTGCG CCCGCTTTAA CTTCGGGGTT AAGCGCCTGG TGACTGTTCT TGACACTGG
G TGCGTGTTTG TTAAACTCTG TGCGGCCGAC GGAGCTGTGC CAGTCTCCCA GCACAGTAGG CAGA
GGGCGG GAGAGGCGGG TGGACCCACC GCGCCGATCC TCTGAGGGGA TCGAGTGGTG GCAGCAGCTA
GGAGTTGATC CGCCCGCGCG CTTTGGGTTT GAGGGGGAAA CCTTCCCGCC GTCCGAAGCG CGCCT
CTTCC CCACGGCCGC GAGTGGGTCC TGCAGTTCGA GAGTTTGGGG TCGTGCAGAG GTCAGCGGAG
TGGTTTGACC TCCCCTTTGA CACCGCGCAG CTGCCAGCCC TGAGATTTGC GCTCCGGGGA TAGGAG
CGGG TACGGGGTGA GGGGCGGGGG CGGTTAAGAC CGCACCTGGG CTGCCAGGTC GCCGCCGCGA A
GACTGGCAG GTGCAAGTGG GGAAACCGTT TGGCTCTCTC CGAGTCCAGT TGTGATGTTT AACCGTC
GGT GGTTTCCAGA AACCTTTTGA AACCCTCTTG CTAGGGAGTT TTTGGTTTCC TGCAGCGGCG CG
CAATTCAA AGACGCTCGC GGCGGAGCCG CCCAGTCGCT CCCCAGCACC CTGTGGGACA GAGCCTGG
CG TGTCGCCCAG CGGAGCCCCT GCAGCGCTGC TTGCGGGCGG TTGGCGTGGG TGTAGTGGGC AGC
CGCGGCG GCCCGGGGCT GGACGACCCG GCCCCCCGCG TGCCCACCGC CTGGAGGCTT CCAGCTGCC
C ACCTCCGGCC GGGTTAACTG GATCAGTGGC GGGGTAATGG GAAGCCACCC GGGAGAGTGA GGAA
ATGAAA CTTGGGGCGA GGACCACGGG TGCAGACCCC GTTACCTTCT CCACCCAGGA AAATGCCCCG
CTCCCTAACG TCCCAAACGC GCCAAGTGAT AAACACGAGG ATGGCAAGAG ACCCACACAC CGGAG
GAGCG CCCGCTTGGG GGAGGAGGTG CCGTTTGTTC ATTTTCTGAC ACTCCCGCCC AATATACCCC
AAGCACCGAA GGGCCTTCGT TTTAAGACCG CATTCTCTTT ACCCACTACA AGTTGCTTGA AGCCCA
GAAT GGTTTGTATT TAGGCAGGCG TGGGAAAATT AAGTTTTTGC GCTTTAGGAG AATGAGTCTT T
GCAACGCCC CCGCCCTCCC CCCGTGATCC TCCCTTCTCC CCTCTTCCCT CCCTGGGCGA AAAACTT
CTT ACAAAAAGTT AATCACTGCC CCTCCTAGCA GCACCCACCC CACCCCCCAC GCCGCCTGGG AG
TGGCCTCT TTGTGTGTAT TTTTTTTTTC CTCCTAAGGA AGGTTTTTTT TCTTCCCTCT AGTGGGCG
GG GCAGAGGAGT TAGCCAAGAT GTGACTTTGA AACCCTCAGC GTCTCAGTGC CCTTTTGTTC TAA
ACAAAGA ATTTTGTAAT TGGTTCTACC AAAGAAGGAT ATAATGAAGT CACTATGGGA AAAGATGGG
G AGGAGAGTTG TAGGATTCTA CATTAATTCT CTTGTGCCCT TAGCCCACTA CTTCAGAATT TCCT
GAAGAA AGCAAGCCTG AATTGGTTTT TTAAATTGCT TTAAAAATTT TTTTTAACTG GGTTAATGCT
TGCTGAATTG GAAGTGAATG TCCATTCCTT TGCCTCTTTT GCAGATATAC ACTTCAGATA ACTAC
ACCGA GGAAATGGGC TCAGGGGACT ATGACTCCAT GAAGGAACCC TGTTTCCGTG AAGAAAATGC
TAATTTCAAT AAAATCTTCC TGCCCACCAT CTACTCCATC ATCTTCTTAA CTGGCATTGT GGGCAA
TGGA TTGGTCATCC TGGTCATGGG TTACCAGAAG AAACTGAGAA GCATGACGGA CAAGTACAGG C
TGCACCTGT CAGTGGCCGA CCTCCTCTTT GTCATCACGC TTCCCTTCTG GGCAGTTGAT GCCGTGG
CAA ACTGGTACTT TGGGAACTTC CTATGCAAGG CAGTCCATGT CATCTACACA GTCAACCTCT AC
AGCAGTGT CCTCATCCTG GCCTTCATCA GTCTGGACCG CTACCTGGCC ATCGTCCACG CCACCAAC
AG TCAGAGGCCA AGGAAGCTGT TGGCTGAAAA GGTGGTCTAT GTTGGCGTCT GGATCCCTGC CCT
CCTGCTG ACTATTCCCG ACTTCATCTT TGCCAACGTC AGTGAGGCAG ATGACAGATA TATCTGTGA
C CGCTTCTACC CCAATGACTT GTGGGTGGTT GTGTTCCAGT TTCAGCACAT CATGGTTGGC CTTA
TCCTGC CTGGTATTGT CATCCTGTCC TGCTATTGCA TTATCATCTC CAAGCTGTCA CACTCCAAGG
GCCACCAGAA GCGCAAGGCC CTCAAGACCA CAGTCATCCT CATCCTGGCT TTCTTCGCCT GTTGG
CTGCC TTACTACATT GGGATCAGCA TCGACTCCTT CATCCTCCTG GAAATCATCA AGCAAGGGTG
TGAGTTTGAG AACACTGTGC ACAAGTGGAT TTCCATCACC GAGGCCCTAG CTTTCTTCCA CTGTTG
TCTG AACCCCATCC TCTATGCTTT CCTTGGAGCC AAATTTAAAA CCTCTGCCCA GCACGCACTC A
CCTCTGTGA GCAGAGGGTC CAGCCTCAAG ATCCTCTCCA AAGGAAAGCG AGGTGGACAT TCATCTG
TTT CCACTGAGTC TGAGTCTTCA AGTTTTCACT CCAGCTAACA CAGATGTAAA AGACTTTTTT TT
ATACGATA AATAACTTTT TTTTAAGTTA CACATTTTTC AGATATAAAA GACTGACCAA TATTGTAC
AG TTTTTATTGC TTGTTGGATT TTTGTCTTGT GTTTCTTTAG TTTTTGTGAA GTTTAATTGA CTT
ATTTATA TAAATTTTTT TTGTTTCATA TTGATGTGTG TCTAGGCAGG ACCTGTGGCC AAGTTCTTA
G TTGCTGTATG TCTCGTGGTA GGACTGTAGA AAAGGGAACT GAACATTCCA GAGCGTGTAG TGAA
TCACGT AAAGCTAGAA ATGATCCCCA GCTGTTTATG CATAGATAAT CTCTCCATTC CCGTGGAACG
TTTTTCCTGT TCTTAAGACG TGATTTTGCT GTAGAAGATG GCACTTATAA CCAAAGCCCA AAGTG
GTATA GAAATGCTGG TTTTTCAGTT TTCAGGAGTG GGTTGATTTC AGCACCTACA GTGTACAGTC
TTGTATTAAG TTGTTAATAA AAGTACATGT TAAACTTACT TAGTGTTATG TTCTGATTTC TGTTGA
CATT CTTTTGGCTA GTAGAAGACA AAAGTAATAC ATTTATGGTA TGCAAAGCAC TATCCTAGGT A
TTTCATTGT AATATTTTAC TTACCCCTTA TCACAACTCT GATAGATTCT GCTTCTGTTA CTAATTA
CAT TTTATAGAAG AGGAAACGGA GGCACAGAAA GCCTAAGTAA CTTGGTTAAA GGCATGTAGT AA
GTATCAAA TCCTGTATTT TAAACCAGGT AACATGACTT AACGAATCTG AAGCCTTCAC CACTTTAA
AT TCAAATGGAA GTTTAGAAAT GGCCAGCCAG CACCTATTTG TATGAAAGGT CATCTTTCAG AGG
ATAAGCA TGTATAAAGA AGAAAAGGTA TGCAGTCGTG TTTGGATTTT ACTCCACCAT C-3' (フ
ラグメント番号 ) (配列番号2463) CD-34核酸およびアンチセンスオリゴヌクレオチドフラグメント 5'-AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAA
GTTAGCA AAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA
AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTC
CTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA TAAATGTGC CACATTGTGG T
TAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCTTTT
GCA AGATTGTTAC TGGCTTACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AA
AAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTA
AG TGGAAGTGGA GCTTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGA
GCCCGAA CAAACCTCCA CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTC
C GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAA
GACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG
GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAG
CCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA
CCGCGCTTTG CTTGCTGAGT TTGCTGC CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCC
T AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCT
GCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC
CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTC
TCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC
GGGGCTGGAC CGCGCTTTGC TTGCTGAGTT TGCTGCCTTC TGGGTTCATG AGTCTTGACA ACAACG
GTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA C
CAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAAT
GAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GT
TTATGGAA ACACAAACTC TTCTGTCCAG TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCC
AG CCAACGTTTC AACTCCAGAG ACAACCTTGA AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACC
TTTCAAC CACTAGCACT AGCCTTGCAA CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCC
T AAGTGACATC AAGGCAGAAA TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATC
TGCCTG GAGCAAAATA AGACCTCCAG CTGTGCGGAG TTTAAGAAGG ACAGGGGAGA GGGCCTGGCC
CGAGTGCTGT GTGGGGAGGA GCAGGCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCT
TGCCC AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA
GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT TCACTG
AGCA AGATGTTGCA AGCCACCAGA GCTATTCCCA AAAGACCCTG ATTGCACTGG TCACCTCGGG A
GCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC GCAGCTGGAG CCCCACA
GGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG GAGGCCAGGG CTATAGCTCA GG
ACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGAC
CG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGT
GACTCGG CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACG
T GCTACCCCCA TGCTGGAGGT GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGA
GGCTGT TCTTGGGGCC CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCCTTTA CACATTCGGC
TCCCTGGAGC CAGACTCTGG TCTTCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAG
AAGCT CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC
TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC TCCCAG
GAAG CTTTGATTTT TACCGTTTCT TCCCTGTATT TTCTTTCTCT ACTTTGAGGA AACCAAAGTA A
CCTTTTGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC CTTGAACCAC TTCCCTC
ATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC CTTGTTCTCT AAGTTCCACT GA
GCTCCATG TGCCCCCTCT ACCATTTGCA GAGTCCTGCA CAGTTTTCTG GCTGGAGCCT AGAACAGG
CC TCCCAAGTTT TAGGACAAAC AGCTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTT
GGGCTCC TTTTTCTCCC TCTGGATCAA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCC
T CTCACCTGTA CTCTTCCGAA AAATCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGAT
CTCCAT GGCTTCCTCC TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA
TGCTTTTCTG TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCAT
AGCCC AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTT
TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA ATAGAA
ATTT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC AAAGTGATGT GTTTAAATAC T
GCAATTAAA GTGATACTGA AACAC-3' (フラグメント番号 ) (配列番号2466) 5'-AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAA
GTTAGCA AAAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGA
A AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACT
CCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA CTAAATGTGC CACATTGTGG
TTAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCTT
TTGCA AGATTGTTAC TGGCTTACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG
AAAAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGT
TAAG TGGAAGTGGA GCTTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT G
GAGCCCGAA CAAACCTCCA CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCC
TCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CC
AAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGA
GG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGG
AGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGG
A CCGCGCTTTG CTTGCTGAGT TTGCTGC-3' (フラグメント番号 ) (配列番号2464)
5'-CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCA
ACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGG
G GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCG
CGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT
GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC GGGGCTGGAC CGCGCTTTGC TTGCT
GAGTT TGCTGCCTTC TGGGTTCATG AGTCTTGACA ACAACGGTAC TGCTACCCCA GAGTTACCTA
CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCC
TTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA A
ACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TTCTGTC
CAG TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTTTC AACTCCAGAG AC
AACCTTGA AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACCTTTCAAC CACTAGCACT AGCCTTGC
AA CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AAGGCAGAAA TCA
AATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA AGACCTCCA
G CTGTGCGGAG TTTAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GCAG
GCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCTTGCCC AGTCTGAGGT GAGGCCTCAG
TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA GCAAACTCCA ACTTATGAAA AAGCA
CCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT TCACTGAGCA AGATGTTGCA AGCCACCAGA
GCTATTCCCA AAAGACCCTG ATTGCACTGG TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCA
CTGG CTATTTCCTG ATGAATCGCC GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC T
TATTACACG GAAAACGGTG GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAG
GGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GG
CCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTG
GG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT GAC
ATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC CTACACCTT
G AGGAGGGGGC AGGTAAACTC CTGTCCTTTA CACATTCGGC TCCCTGGAGC CAGACTCTGG TCTT
CTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT CCCAGGAACA ATCGATGGCC
TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC TCTCTGCCGC AATACAGGAA CCCCC
AGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC TCCCAGGAAG CTTTGATTTT TACCGTTTCT
TCCCTGTATT TTCTTTCTCT ACTTTGAGGA AACCAAAGTA ACCTTTTGCA CCTGCTCTCT TGTAAT
GATA TAGCCAGAAA AACGTGTTGC CTTGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTGG A
CTTGGTCAC CAGCTCCTCC CTTGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCATTT
GCA GAGTCCTGCA CAGTTTTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTTT TAGGACAAAC AG
CTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC TTTTTCTCCC TCTGGATC
AA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTTCCGAA AAA
TCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC TCCCTCCTG
C CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTTTTCTG TCTCTGCCTC CCTC
ACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC AGATCAGCTC CTAACCCTTA
TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTT TGCTGTTGAT TTCTTTCCAG AGGGG
TTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA ATAGAAATTT CCAGAGAAGA GAGTATTGGG
TAGATATTTT TTCTGAATAC AAAGTGATGT GTTTAAATAC TGCAATTAAA GTGATACTGA AACAC-
3' (フラグメント番号 ) (配列番号2465) エオタキシン(Eotaxin)アンチセンス核酸およびオリゴヌクレオチドフラグメ
ント 5'-GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC CAC
CTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC TGTGGCTGC
T GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG TCCCAACCAC CTGC
TGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA GCTACAGGAG AATCACCAGT
GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC TGGCCAAGGA TATCTGTGCC GACCC
CAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC TGGACCAAAA ATCTCCAACT CCAAAGCCAT
AAATAATCAC CATTTTTGAA ACCAAACCAG AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTAC
AATG CATTCTGAGG TAACCTCATT ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA T
TTTTTTTTT AAAAAAAAAC GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAAT
ATC AGTTATTTTT AAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG AT
CCCCTGTC ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCT
GG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA TGG
AAGTAAA TGTTGTTTTA GGAATAC ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG C
AGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCT
GGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TC
CCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGT
GG GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA CCACATATT
C CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GCTT
GCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCTTCA
TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGG
CAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA
AAGCTCACAC CTTCAGCCTC CAACATGAAG GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCA
GCTG CCTTCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT A
AGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAAATTC TCCATTT
GAA AAATAGGGAA ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TG
GAAGAGCC AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACATTCAAGA GGGCCGCTGG GTGCATCC
TT ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG TGG
GCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTTAA TTCGACTCC
A GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT CTCTTGAGGT GACT
TATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA ACTCATTTTC CCATACTCTG
GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAACAAACA GTTCT
AAATT ATCAATGACT TAACAGAATT AACTAAATTA ACAAAAGTTA CTTTCTCACT TGTACTAAAT
ATCTATAATG TATGGGCTCA GGCTTCTGCA TTTTATACTC AGGATTCTAG ACTGATGGAG AAGTTG
CCAT GTGGGGGAAC ATTGATGGAT ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT A
GGCAATGCA CTGTGGCTCA AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTGATCA AAACTAA
TTA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AG
GATGGAGA ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTTTAT AATGACAG
AG CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG ATGAGTCCTC AGT
GCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA GAGCAGAGG
G ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA CTTCCTTTAC AAAGTCATGC TTGG
AAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT TTTTTTCCCC AAAATTCAGC
TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG AAGATACCCC TTCAGCGACT AGAGA
GCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC
CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTG
ATAG TTTGACCTCT ATGGTCCAAT TCATTAATTT TCACAAGTGA GTGTTCACTC CCAGCTCCCT G
CCTGGGAGA TTGCTGTAGT CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTTAC TGGGCCT
TTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA GG
GGCAGATG GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA AACAATCCTT CCAATTGC
AT CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG AAG
AAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA TAAATAATC
A CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC TTCTTACAAT GCAT
TCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT ATATATATAT ATATATTTTT
TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT TAAAACTTAT CCTCCATGAA TATCA
GTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT TTACCCCCTG GGAGCCCCAA TTCGATCCCC
TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCA
AAGA TGATCAGTAT GAAAATGTCA TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG T
AATGTTGTT TTAGGAATAC ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTTGTAA TTTTTTT
GTG GGAAATCCAC ACTGAGCTGA GGGGG-3' (フラグメント番号 ) (配列番号2494)
5'-GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC CAC
CTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC TGTGGCTGC
T GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG TCCCAACCAC CTGC
TGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA GCTACAGGAG AATCACCAGT
GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC TGGCCAAGGA TATCTGTGCC GACCC
CAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC TGGACCAAAA ATCTCCAACT CCAAAGCCAT
AAATAATCAC CATTTTTGAA ACCAAACCAG AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTAC
AATG CATTCTGAGG TAACCTCATT ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA T
TTTTTTTTT AAAAAAAAAC GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAAT
ATC AGTTATTTTT AAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG AT
CCCCTGTC ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCT
GG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA TGG
AAGTAAA TGTTGTTTTA GGAATAC-3' (フラグメント番号 ) (配列番号2491) 5'-ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGG
CTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTT
C AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAA
GACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA
TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA-3' (フラグメント番号 ) (配列番
号2492) 5'-CCACATATTC CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCT
CCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAG
G AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC CACACTGTCT GCTC
CCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC
TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG GTCTCCGCAG CACTTCTGTG GCTGC
TGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCCCC CAACTCCTTA
CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAA
ATTC TCCATTTGAA AAATAGGGAA ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC A
TCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACATTCAAGA GGGCCGC
TGG GTGCATCCTT ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GT
GGGCATGG TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTT
AA TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT CTC
TTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA ACTCATTTT
C CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAA
CAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA ACAAAAGTTA CTTTCTCACT
TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA TTTTATACTC AGGATTCTAG ACTGA
TGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT ACTGTGATAA AGCAGAAGAA AGCTCTCAGG
AGTCTTGCAT AGGCAATGCA CTGTGGCTCA AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTG
ATCA AAACTAATTA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT C
TCAAAACAG AGGATGGAGA ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTT
TAT AATGACAGAG CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG AT
GAGTCCTC AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTT
CA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA CTTCCTTTAC AAA
GTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT TTTTTTCCC
C AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG AAGATACCCC TTCA
GCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTGTGA TGTAAGTAAA
TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC AAGAACTGTG GGAGT
CATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT TCATTAATTT TCACAAGTGA GTGTTCACTC
CCAGCTCCCT GCCTGGGAGA TTGCTGTAGT CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTT
TTAC TGGGCCTTTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC C
CTTTGTCCA GGGGCAGATG GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA AACAATC
CTT CCAATTGCAT CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CG
ACCCCAAG AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGC
CA TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC TTC
TTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT ATATATATA
T ATATATTTTT TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT TAAAACTTAT CCTC
CATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT TTACCCCCTG GGAGCCCCAA
TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCTTCCTC CCTGGAATCT TGTAA
AGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTTGT GAACCCAAAG TGTGACTCAT
TAAATGGAAG TAATGTTGTT TTAGGAATAC ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTT
GTAA TTTTTTTGTG GGAAATCCAC ACTGAGCTGA GGGGG-3' (フラグメント番号 ) (
配列番号2493) FK-506結合性タンパク質核酸およびオリゴヌクレオチドフラグメント 5'- GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CG
CCATGGGA GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTG
GG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG AAG
GGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGA
G ACAGAAACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA GGTTTTGAAG AGGG
TGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC
CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACT
TAGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC
TCTGCCACTG GGACGGCTCC TGCTTTTGGG GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGG
CATC ATCCATTCTC TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG C
TTGAGGAAA CTTCGGTTGC AGATTGAAGC ATTTCAGGTT GTGCATTTTG TGTGATGCAT GTAGTAG
CCT TTCCTGATGA CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT AA
ACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCC
AG TTACCTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT AAACAATGTC CTC
TTTGAGA AAATGTAAAA TAAAGGCTCT GTGCTTGACA GAATTCGGGC CGCCGCCAGG TCGCTGTTG
G TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGG
AAACCA TCTCCCCAGG AGACGGGCGC ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA
CCGGGATGCT TGAAGATGGA AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTT
ATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA
GAGAGCCAAA CTGACTATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCC
ACCA CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT C
CCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA CATGAGT
CCA TATGGAGCTT TTCCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT GACTGAATGT GT
TCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTTCCT CTTCCCCTTT CTCCTCGTAT GTGTGTTT
AC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATTTTATT TTGTTTTCAT TTTGGGGTGA AGA
TTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATTAA GTACATGGTC AAGTATTAAC AGCACAAGT
G GTAGGTTAAC ATTAGAATAG GAATTGGTGT TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAA
TTTTTT GGATGAAATT TTTATCTATT ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG
CAGATTTGAG GCGCTGTTGA GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATT
AAAAG CCCTACCTAA AACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC
CTCCCCTTAA ACCCTCTGCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTAT
CTGT CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTTGTGGCC TTTTTTTTTT TTCATCCTGT G
GTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT TCCTAAA
TCT TAAGAACTTT AATTGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA CACCCAGTGA AA
GCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCTTAA GAAAATGATG CTGGTCATCG CAGCTTCA
GC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TGCTGATCTC AGTTTCCTGG CTTTTCCTCC CTC
AGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTGAT TTGGTGAGAA ATCGTTGCTG CACCCTTCC
C CCAGCACCAT TTATGAGTCT CAAGTTTTAT TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC G
CCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC AAGCGCG
GCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT GATTCCTCCC GG
GACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGG
GT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATT ATGCCTATGG TGC
CACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT CTCGTCTTCG ATGTGGAGCT TCTAAAACT
G GAATGACAGG AATGGCCTCC TCCCTTAGCT CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGT
GCCTCC AGACATGTGC ACATGARTCC ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG
ACATCTGCCC TGACTGAATG TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTC
CCCTT TCTCCTCGTA TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA-3' (フ
ラグメント番号 ) (配列番号2499) 5'- GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CG
CCATGGGA-3' (フラグメント番号 )(配列番号2495) 5'-GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG CCG
CTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG AAGGGCCAAA
CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGAG ACAGA
AACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA GGTTTTGAAG AGGGTGCAGC
CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGG
CCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG T
GAAGGCAGG AAGGAACTCA AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCA
CTG GGACGGCTCC TGCTTTTGGG GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC AT
CCATTCTC TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG CTTGAGGA
AA CTTCGGTTGC AGATTGAAGC ATTTCAGGTT GTGCATTTTG TGTGATGCAT GTAGTAGCCT TTC
CTGATGA CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT AAACCACAC
A CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCCAG TTAC
CTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT AAACAATGTC CTCTTTGAGA
AAATGTAAAA TAAAGGCTCT GTGCTTGACA-3'(フラグメント番号 ) (配列番号2496
) 5'-GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCA
GCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC ACCTTCCCC
A AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAATTTG ATTC
CTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA
AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA CTGACTATAT CTCCAGATTA TGCCT
ATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA CATGCCACTC TCGTCTTCGA TGTGGAGCTT
CTAAAACTGG AATGACAGGA ATGGCCTCCT CCCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGG
ATCT GGTGCCTCCA GACATGTGCA CATGAGTCCA TATGGAGCTT TTCCTGATGT TCCACTCCAC T
TTGTATAGA CATCTGCCCT GACTGAATGT GTTCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTT
CCT CTTCCCCTTT CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TC
ATTTTATT TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATT
AA GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAGAATAG GAATTGGTGT TGG
GGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT TTTATCTATT ATATATTAA
A CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTGTTGA GGACTGAATT ACTC
TCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA AACTGAGGTG GGGATGGGGA
GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA ACCCTCTGCC TTTGAAAGTA GATCA
TGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT CTGAAGCCTT
CTTTGTGGCC TTTTTTTTTT TTCATCCTGT GGTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCT
CATA ACTTTCCAAG CTCCACCACT TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA G
GTGCTGTTT GTAGACTTAA CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCT
TAA GAAAATGATG CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TG
CTGATCTC AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTG
AT TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTTTTAT TAT
TGCAATA AAAGTGCTTT ATGCCCGAAT TC-3' (フラグメント番号 ) (配列番号2497
) 5' GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC AAG
CGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT GATTCCTCC
C GGGACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGA
AGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATT ATGCCTATGG
TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT CTCGTCTTCG ATGTGGAGCT TCTAA
AACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT CCCTGTTCTT GGATCTGCCR TGGAGGGATC
TGGTGCCTCC AGACATGTGC ACATGARTCC ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGT
ATAG ACATCTGCCC TGACTGAATG TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC T
CTTCCCCTT TCTCCTCGTA TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA-3'
(フラグメント番号 ) (配列番号2498)

【００２８】 このとき、Bは、アデノシンである、または、より好ましくはアデノシンを置
換し、そして「等価」または「一般」塩基、およびアデノシンA_2aレセプターア
ゴニストまたは最少ではアンタゴニストのみ、アデノシンA_2bレセプターアンタ
ゴニスト、アデノシンA₃レセプターアンタゴニスト、またはアデノシンA₁レセプ
ターアンタゴニストである。同様に、上記のように、アデノシン（A）を、常に
、好ましくはアデノシンレセプターでのアデノシンの活性の0．3より少ない、小
断片を持つ、「代替」「等価」および／または「一般」塩基によって置換するこ
とができる。 一つの好ましい実施態様では、隣接したモノヌクレオチド間の結合は、ホスホ
ジエステル結合である。もう一つの好ましい実施態様では、アンチセンスオリゴ
ヌクレオチドの少なくとも1つのモノヌクレオチドホスホジエステル残基を、メ
チルホスホネート、ホスホトリエステル、ホスホロチオエート、ホスホロジチオ
エート、ボラノホスフェート、ホルムアセタール、チオホルムアセタール、チオ
エーテル、カルバネート、カルバメート、スルフェート、スルホネート、スルフ
ァメート、スルホンアミド、スルホン、スルファイト、スルホキシド、スルフィ
ド、ヒドロキシアミン、2’-O-メチル、メチレン（メチルイミノ）、メチレンオ
キシ（メチルイミノ）、ホスホルアミデート残基およびその組み合わせで、置換
する。1以上のホスホジエステル残基を1以上の他の残基で置換したオリゴスは、
これらの残基がホスホジエステル残基より加水分解により耐性である限りにおい
て、一般により長く長持ちする。ある場合、最大で約10％、約30％、約50％、約
75％そして全ホスホジエステル残基さえも、置換する（100％）ことができる。
典型的には、本発明の複数の標的アンチセンスオリゴヌクレオチド（オリゴス）
は、少なくとも約7モノヌクレオチド、ある例では、最大で60およびそれより多
くのモノヌクレオチド、好ましくは約10〜約36、より好ましくは約12〜約21モノ
ヌクレオチドを含む。しかしながら、その他の長さもまた、標的の巨大分子の長
さによっては、適当である。94の配列（配列番号2316〜2410）を含む、本発明の
MTAオリゴスの例を以下のtable3に提供する。

【００２９】

【表３】

【００３０】

【表４】

【００３１】 table3のMTAオリゴスは、以下のtable4に列挙した2以上の標的との使用に適し
ている。

【００３２】

【表５】

【００３３】 標的タンパク質のmRNA配列を、現存する標的、または未来に見つかるであろう
それらのためのいずれかのタンパク質を発現する遺伝子のヌクレオチド配列から
誘導することができる。異なる系の数多くの標的遺伝子の配列が、現在知られて
いる。GenBankデータベース、NIH（その全体配列をここに参照として採用する）
を参照のこと。配列が未だ入手できない、それらの遺伝子の配列は、この技術分
野で既知の技術を適用する標的セグメントを単離することによって、得ることが
できる。ひとたび、遺伝子の配列、そのRNAおよび／またはタンパク質が知られ
ると、アンチセンスオリゴヌクレオチドを、上記の方法に従って、作成すること
ができ、インビボで投与することによって標的に効力を与えるために利用され、
そして、標準技術に従って標的化タンパク質の生成、および特異的機能の減少に
ついて試験する。既に上記したように、アンチセンスオリゴヌクレオチドは、結
合する特定の標的およびその送達様式に依存して、任意の適当な長さ、例えば約
7-約60ヌクレオチドの長さ、であることができる。アンチセンスオリゴヌクレオ
チドは、好ましくは、イントロンとエキソンの間の接合部を含むmRNA領域、また
は接合部に近接した領域に向けられる。アンチセンスオリゴヌクレオチドがイン
トロン／エキソン接合部に向けられると、それは、接合部を全体的に覆う、また
は接合部に充分に接近するかのいずれかであり、例えば、イントロン／エキソン
接合部の例えば約10、5、3または2ヌクレオチド内に位置するアンチセンスオリ
ゴヌクレオチドの3’または5’末端を持ち、前駆体mRNAの成熟mRNAへのプロセシ
ング中の介在エキソンのスプライスによる切り出しを阻害することができる。ま
た、開始コドン、より一般的には、標的mRNAのコード領域を標的とするそれら、
を覆うアンチセンスオリゴヌクレオチドが望ましい。本発明の実施に当たって、
投与されるアンチセンスオリゴヌクレオチドを、投与される種のオリジンと関連
させることができる。ヒトを治療する場合、所望であれば、ヒトアンチセンスを
用いることができる。しかしながら、その他の種からの内因性配列に対するアン
チセンスオリゴスもまた包含される。

【００３４】 細胞膜を通過することによってA₁またはA₃アデノシンレセプターの発現を減少
させるために有効な、上記に与えられたような、アンチセンスオリゴヌクレオチ
ドを含み、細胞内のA₁またはA₃アデノシンレセプターをコードするmRNAと特異的
に結合し、そうすることによってその翻訳を防ぐ、医薬組成物もまた、本発明の
もう一つの態様である。そのような組成物を、適当な医薬として許容しうる担体
、例えば、無菌のピロゲン非含有の生理食塩水、内に提供する。アンチセンスオ
リゴヌクレオチドを、細胞膜を通過する能力を持つ疎水性担体、例えばリポソー
ム内では、医薬として許容しうる水溶性担体内に保たれたリポソームと共に、調
合することができる。オリゴヌクレオチドは、リボザイムのような、mRNAを不活
性化する物質と結合させることもできる。そのようなオリゴヌクレオチドを、こ
こに議論した任意の理由のためにそのような治療を必要とする患者に投与し、ア
デノシンレセプターのような、標的の活性化を防ぐことができる。さらに、医薬
調合物もまた、細胞内に取り込まれることが知られている分子に接着したアンチ
センスオリゴヌクレオチドを含む、キメラ分子を含むことができる。これらのオ
リゴヌクレオチド接合体は、オリゴヌクレオチドの細胞濃度を増加させるために
、細胞摂取経路を利用する。この様式に用いられた巨大分子の例としては、トラ
ンスフェリン、（ポリリシンを通してオリゴヌクレオチドと結合した）アシアロ
グリコプロテイン、およびストレプトアビジン、が含まれる。医薬調合物内では
、リポソームまたは微小結晶のような、脂質粒子またはベシクル内に、アンチセ
ンス化合物を含むことができる。粒子は、アンチセンスオリゴヌクレオチドがそ
の中に含まれる限りにおいて、ユニラメラまたはプルリラメラのような、任意の
適当な構造からなる。N-［1-（2，3-ジオレオイロキシ）プロピル］-N，N，N-ト
リメチルアンモニウムエチルスルフェートのような正にチャージした脂質、また
は”DOTAP”は、そのような粒子およびベシクルに特に好ましい。そのような脂
質粒子の調製は、良く知られている。例えば、合衆国特許第4，880，635号、Jan
offら；第4，906，477号、Kuronoら；第4，911，928号、Wallach；第4，917，95
1号、Wallach；第4，920，016号，Allenら；第4，921，757号、Wheatleyら；等
を参照のこと。

【００３５】 アンチセンスヌクレオチド組成物が肺に輸送される任意の手段で、患者に活性
組成物を投与することができる。アンチセンス化合物は、特に本明細書中に開示
されており、任意の適当な手段によって患者の肺に投与することができるが、好
ましくは、吸入可能粒子からなすエアゾールを生成することによって投与され、
吸入可能粒子は、アンチセンス化合物からなり、その粒子を患者が吸う。吸入可
能粒子は、液体または固体であることができる。所望であれば、粒子は、その他
の治療成分を含むことができる。本発明を実施するためのアンチセンス化合物か
らなる粒子は、吸入可能な大きさの粒子：即ち、吸入時に口および咽頭を通り、
肺の気管支および肺胞内に達するに充分に小さいサイズの粒子：を含んでいなけ
ればならない。一般に、約5〜約10ミクロンの大きさの範囲の粒子が吸入可能で
ある。エアゾール内に含まれる吸入できない大きさの粒子は、咽喉内に残されて
飲み込まれがちであり、エアゾール内の吸入不能粒子の量は最少であることが好
ましい。鼻投与では、10〜500μmの範囲内の粒子の大きさが、鼻腔内の保持を確
実にするために好ましい。従って、その中で、約4、約10、約25、約50〜約75、
約100、約250、約500およびその他の特定範囲の粒子が好ましい。しかしながら
、その他もまた、本発明の制限内で計画される。

【００３６】 エアゾールを作るための活性化合物の脂質医薬組成物は、無菌のプロゲン非含
有水のような、適当なベヒクルとアンチセンス化合物を結合させることにより、
調製することができる。所望により、その他の治療化合物も含むことができる。
微小化したアンチセンス化合物の吸入可能の乾燥粒子を含む固体粒子組成物は、
乾燥アンチセンス化合物をモーターおよび乳棒で粉砕し、次に400メッシュスク
リーンを通して微小化組成物を通過させ、大きい塊を粉々に砕くかまたは分離除
去する。アンチセンス化合物からなる固体粒子組成物は、所望により、エアゾー
ルの形成を容易にするために提供される分散剤を含むことができる。適当な分散
剤は、ラクトースであり、それを任意の適当な比率（例えば重量比率で1：1）で
アンチセンス化合物と混合することができる。再度、その他の治療化合物を、含
ませることもまたできる。

【００３７】 投与されたアンチセンス化合物の投与量は、治療される疾病、患者の状態、特
定の調合物、投与経路、患者への投与のタイミング等に依存するであろう。一般
に、約0．01、約0．05、約0．1、約0．2、約1〜約5μM、約50μM、約100μMまた
はそれより多く、より特別には、約0．2〜約0．5μM、の細胞内濃度のオリゴヌ
クレオチドが望ましい。ヒトのような患者への投与について、約0．01、約0．1
または約1mg／Kgから、最大で約50、約100、または約150mg／Kgまでの投与量、
それよりなお高い投与量が、典型的には、この技術分野で既知の投与経路に依存
して、用いられる。投与される活性化合物の特定の調合物の溶解度に依存して、
毎日の投与量を、1〜数単位の投与量に分けることもできる。アンチセンス化合
物の投与は、治療的（即ち救命治療として）または予防的に実行することができ
る。アンチセンス化合物を含む液体粒子のエアゾールは、ネブライザのような任
意の適当な手段によって作り出すことができる。合衆国特許第4，501，729号を
参照のこと。ネブライザは、市販されている装置であり、圧縮気体、典型的には
空気または酸素、を狭いベンチュリ管口を通して加速することによって、または
超音波攪拌によって、のいずれかで、活性成分の溶液または乳濁液を治療用エア
ゾールミストに転換する。ネブライザでの使用に適した調合物は、液体担体内の
活性成分からなり、活性成分は、最大で40％w／wの調合物を含むが、好ましくは
20％w／w以下である。担体は、典型的には、水、または希釈したアルコール性水
溶液であり、好ましくは、例えば塩化ナトリウムを加えることによって、体液と
等張になるように作られる。所望される添加物には、もし調合物が無菌に調製さ
れていない場合は、防腐剤、例えばメチルヒドロキシベンゾエート、好酸化剤、
香味剤、揮発油、バッファー剤および界面活性剤が含まれる。

【００３８】 一つの実施態様では、医薬組成物は、上記のアンチセンスオリゴ（単数または
複数）を含む核酸、および1以上の界面活性剤を含む。本発明のアンチセンスオ
リゴヌクレオチドの摂取を強化するために適当な界面活性剤または界面活性剤化
合物には、その他にもいろいろあるが、合成および天然ならびに全体および切除
型のサーファクタント（界面活性）プロテインA、サーファクタントプロテインB
、サーファクタントプロテインC、サーファクタントプロテインD、サーファクタ
ントプロテインE、二飽和ホスファチジルコリン（ジパルミトイル以外）、ジパ
ルミトイルホスファチジルコリン、ホスファチジルコリン、ホスファチジルグリ
セロール、ホスファチジルイノシトール、ホスファチジルエタノールアミン、ホ
スファチジルセリン；ホスファチジド酸、ユビキノン、リソホスファチジルエタ
ノールアミン、リソホスファチジルコリン、パルミトイル-リソホスファチジル
コリン、デヒドロエピアンドロステロン、ドリコール、スルファチド酸、グリセ
ロール-3-リン酸、ジヒドロキシアセトンホスフェート、グリセロール、グリセ
ロ-3-ホスホコリン、ジヒドロキシアセトン、パルミテート、シチジンジホスフ
ェート（CDP）、ジアシルグリセロール、CDPコリン、コリン、コリンホスフェー
ト；ならびに界面活性剤の成分のための天然担体ベヒクルである天然および人工
のラメラ体、ο-3脂肪酸、ポリエン酸(polyenic acid)、ポリエン酸(polyenoic
acid)、レシチン、パルミチン酸、エチレンまたはポリエチレンオキシドの非イ
オンブロックコポリマー、ポリオキシプロピレン、ポリオキシエチレン単量体お
よび重合体、デキストランおよび／またはアルカノイル側鎖を持つポリ（ビニル
アミン）、Brij35、Triton X-100、および合成界面活性剤ALEC、Exsurf、Surva
nおよびAtavaquoneが含まれる。これらの界面活性剤は、単独で、または複数成
分の部分として、調合物中の界面活性剤として、またはアンチセンスオリゴスの
5’および／または3’末端への共有結合付加物として、のいずれかで、用いるこ
とができる。活性成分を含む固体粒子のエアゾールは、同様に、任意の固体粒子
薬剤エアゾール生成器で作り出され得る。固体粒子薬剤を患者に投与するための
エアゾール生成器は、上記のように、吸入可能である粒子を生成し、ヒト投与に
適当な速度であらかじめ決められた計量された投薬量の薬剤を含む1容量のエア
ゾールを作り出す。固体粒子エアゾールの一つの例示的な型は、注入器である。
注入剤によって投与するための適当な調合物は、注入器によって送達される、ま
たは嗅剤の様式で鼻腔内に摂取することができる、細かく粉砕された粉末を含む
。注入剤内では、粉末（例えばここに記載された治療の実行に有効なその計量さ
れた投与量）は、典型的には、ゼラチンまたはプラスチックから作られた、カプ
セルまたはカートリッジ内に含まれ、それらは使用位置で穴を開けられるか、ま
たは開かれるかのいずれかであり、そして粉末は、吸入時に装置を通して吸い出
された空気によって、または手動操作ポンプによって、送達される。注入器内で
用いられた粉末は、活性成分単独で、または、活性成分、ラクトースのような適
当な粉末希釈剤、および所望であれば界面活性剤を含む粉末混合物のいずれかか
らなる。活性成分は、典型的は、0．1〜100w／wの調合物からなる。例としての
エアゾール生成器の第二の型には、計量した投与量の吸入器が含まれる。計量し
た投与量の吸入器は、典型的には、液化発射薬内に活性成分の乳濁液または溶液
調合物を含む、エアゾールディスペンサーに圧力をかける。使用中、これらの装
置は、計量した容量、典型的には10〜150：1、を送達するように合わせたバルブ
を通して調合物を放出し、活性成分を含む細かい粒子噴霧を作り出す。適当な発
射剤には、ある種のクロロフルオロカーボン化合物、例えば、ジクロロジフルオ
ロメタン、トリクロロフルオロメタン、ジクロロテトラフルオロエタンおよびそ
の混合物が含まれる。調合物は、さらに、1以上の共溶媒、例えば、エタノール
、オレイン酸またはソルビタントリオレアートの様な界面活性剤、抗酸化剤およ
び適当な香味剤を含むことができる。エアゾールは、固体または液体粒子のいず
れかから形成されるが、例えば約10、約30、約70〜約100、約150、約150リット
ル／分、より好ましくは約30〜約150リットル／分、最も好ましくは約60リット
ル／分の速度で、エアゾール生成器によって、作ることができる。しかしながら
、この技術分野で既知であるように、より多量の薬剤を含むエアゾールを、より
速く投与することもできる。

【００３９】 本発明に引用したすべての化学文献および特許引例の適当な開示は、特に、本
発明を可能にする調製方法および技術の参考として、本明細書中に特に参照とし
て採用するつもりである。以下の実施例は、本発明を説明するために提供され、
それらの限定として解釈されるべきではない。

【００４０】

【実施例】

以下実施例では：Mはマイクロモルを意味し、mlはミリリッターを意味し、：m
はマイクロメートルを意味し、mmはミリメートルを意味し、cmはセンチメートル
を意味し、ECは摂氏温度を意味し、；gはマイクログラムを意味し、mgはミリグ
ラムを意味し、gはグラムを意味し、kgはキログラムを意味し、Mはモルを意味し
、そしてhまたはhrは時間を意味する。

【００４１】 実施例1：（アンチセンスオリゴヌクレオチドの設計と合成） A1およびA3アデノシンレセプターに対するアンチセンスオリゴヌクレオチドの
設計は、ターゲットA₁レセプターmRNAおよびターゲットA₃レセプターmRNAの複雑
な二次構造の解明を必要とするだろう。この構造を形成した後にmRNAに機能的活
性または安定性を付与すると解釈されるmNRAの領域をターゲットとし、さらに開
始コドンを最適に覆うアンチセンスヌクレオチドが設計される。その他の標的部
位も容易に利用できる。アンチセンス効果の特異性のデモンストレーションにお
いて、標的mRNAに対し完全には相補的でないがw／wベースにて同一なヌクレオチ
ド組成を有する他のオリゴヌクレオチドは、アンチセンス実験にコントロールと
して含まれる。

【００４２】 アデノシンA1レセプターのmRNA二次構造は上記の如くに解析され、利用され、
ホスホロチオネートアンチセンスオリゴヌクレオチドが設計された。合成された
アンチセンスオリゴヌクレオチドはHAdA1ASと命名され、以下の配列を有する：5
’−GAT GGA GGG CGG CAT GGC GGG−3’（配列番号1）。コントロールとして
、以下の配列を持つ、HAdA1MM1と命名されたミスマッチ型ホスホロチオネートア
ンチセンスヌクレオチドが合成された：5’−GTA GCA GGC GGG GAT GGG GGC
−3’（配列番号2）。各オリゴヌクレオチドは同一の塩基含有量および一般（ge
neral）配列構造を有する。GENBANK（85．0版）およびEMBL（40．0版）でのホモ
ロジー検索は、アンチセンスオリゴヌクレオチドがヒトおよびウサギのアデノシ
ンA₁レセプター遺伝子に対し特異的であること、そしてミスマッチコントロール
はいずれのかの既知遺伝子配列とのハイブリダイゼーションに関する候補ではな
いことを示した。

【００４３】 アデノシンA₃レセプターmRNAの二次構造も上記の如くに同様に解析され、用い
られて2種類のホスホロチオネートアンチセンスオリゴヌクレオチドが設計され
た。合成された第1のアンチセンスオリゴヌクレオチド（HAdA3AS1）は以下の配
列を有した：5’−GTT GTT GGG CAT CTT GCC−3’（配列番号3）。コントロー
ルとして、以下の配列を持つミスマッチ型ホスホロチオネートアンチセンスオリ
ゴヌクレオチド（HAdA3MM1）が合成された：5’−GTA CTT GCG GAT CTA GGC−
3’（配列番号4）。第2のホスホロチオネートアンチセンスオリゴヌクレオチド
（HAdA3AS2）も、以下の配列を有する様に設計され、合成された：5’−GTG GGC
CTA GCT CTC GCC−3’（配列番号5）。そのコントロールオリゴヌクレオチド
（HAdA3MM2）は次の配列を有した：5’−GTC GGG GTA CCT GTC GGC−3’（配
列番号6）。ホスホロチオネートオリゴヌクレオチドは、アプライドバイオシス
テムス（Applied Biosystems） モデル396 オリゴヌクレオチド合成装置にて合
成され、NENSORBクロマトグラフィー（デュポン、メリーランド州）（DuPont、M
D）を用い精製された。

【００４４】 実施例2：（アデノシンA₁レセプターアンチセンスオリゴのインビトロ試験） 上記のヒトA₁レセプター（配列番号1）に対するアンチセンスオリゴヌクレ
オチドを、肺腺ガン細胞HTV−54を用いたインビトロモデルにおける効力につい
て試験した。HTB−54肺腺ガン細胞については、通常のノーザンブロット法と研
究室にて設計および合成されたレセプタープローブを用いA₁アデノシンレセプタ
ーを発現していることが示された。

【００４５】 HTB−54ヒト肺腺ガン細胞（10⁶／100mm組織培養皿）は、12時間後に培地とオ
リゴヌクレオチドを新たに交換（クロスオーバー）し、24時間5．0：MのHAdA1AS
またはHAdA1MM1に曝した。オリゴヌクレオチドに24時間曝した後、細胞を集め、
RNAを通常の方法にて抽出した。アンチセンスが標的とするmRNA領域に対応した2
1−merのプローブ（従って、アンチセンスと同一配列を有するがホスホロチオ酸
化されていない）を合成し、これを用いてHAdA1ASおよびHAdA1MM1で処理し、あ
るは処理しなかったHTP−54細胞から調製したRNAをブロットし、探索した。これ
らブロットより、HAdA1ASはヒトアデノシンレセプターmRNAを＞50％効果的に減
少させたが、HAdA1MM1はそうではなかったことが明瞭に示された。この結果より
HAdA1ASは喘息に関係するアデノシンA₁レセプターの細胞内mRNAを消耗させるこ
とから、抗喘息薬の良好な候補であることが示された。

【００４６】 実施例3：（アデノシンA₁レセプターアンチセンスオリゴのインビボ効果） 開始コドンを覆うアデノシンA₁遺伝子内のウサギとヒトDNA配列間に偶然にも
相同性があったことから、当初ヒトアデノシンA₁レセプターへの利用を目的に設
計されたホスホロチオネートはウサギモデルでも利用できた。ニュージランド白
色無パスツレラウサギの新生児を、出産24時間以内に10％カオリンと混合した31
2抗原単位／mlの家ダニ（D．Farinae）抽出物（バークレーバイオロジカルス、
バークレー、カリフォルニア州（Berkeley Biologicals、Berkeley、CA）0．5m
lで免疫感作した。免疫感作は1ヶ月間は毎週、続く2ヶ月間は2週おきに繰り返し
た。3−4月齢時に、8匹の感作ウサギに塩酸ケタミン（44mg／kg）およびアセプ
ロマジンマレイン酸塩（0．4mg／kg）を筋肉注射し、麻酔し弛緩させた。次にウ
サギを、小型の型取りされ、パッドが敷かれた板の上に快適な姿勢で仰臥させ、
4．0mm気管挿入管（マリンクロット社、グレンフォール、ニューヨーク（Mallin
krodt、Inc．，Glens Falls、NY））を挿入した。附属のラテックスバルーンの
付いた外直径2．4mmのポリエチレン製カテーテルを食道に通し、実験を通じ、口
から同一距離（約16cm）に維持した。気管内チューブは加温されたフレイシュニ
ューモタコグラフ（サイズ00：DOMメディカル、リッチモンド、バージニア（DOM
Medical、Richmond，VA））に接続され、流量はゴールドキャリアー（Gould ca
rrier）増幅器（モデル11−4113、ゴールドエレクトロニクス社、クリーブラン
ド、オハイオ（Gould Electronic、Cleveland、OH）により駆動されるバリダイ
ン差圧トランスデューサー（モデルDP−45161927；バリダインエンジニアリング
社、ノースリッジ、カリフォルニア（Validyne Engineering Corp．，Northrid
ge，CA））により測定された。食道バルーンは差圧トランスデューサーの一方側
に取り付けられ、気管内チューブの出口は圧トランスデューサーの反対側に接続
され、経肺圧が記録された。流量は積算されて連続した一回換気量が求められ、
そして等容点および流量ゼロ点それぞれについて、総肺抵抗（RL）および動肺コ
ンプライアンス（C_dyn）値を自動呼吸分析装置を利用し計算した（モデル6；Bux
co、Sharon、CT）。動物は無作為化され、1日目にPC₅₀に関する処置前値がエア
ゾール化アデノシンについて求められた。アンチセンス（HAdA1AS）またはミス
マッチコントロール（HAdA1MM）オリゴヌクレオチドは滅菌生理食塩水に5000：g
（5mg）／1．0mlの濃度に溶解された。続いて気管内チューブを通して動物にエ
アゾール化されたアンチセンスまたはミスマッチオリゴヌクレオチドが、2日間
、1日2回投与された（1．0ml中におよそ5000：g）。生理食塩水、アデノシン、
またはアンチセンスあるいはミスマッチオリゴヌクレオチドのエアゾールは、超
音波噴霧器（DeVilbiss、Somerset、PA）を用い生成され、得られたエアゾール
滴は80％が直径5：m以下であった。最初の実験では、4匹の無作為に選択された
アレルギー性ウサギにはアンチセンスオリゴヌクレオチドが、4匹にはミスマッ
チコントロールオリゴヌクレオチドが投与された。3日目の朝にPC₅₀値（ベース
ライン値より気管支気道の動的コンプライアンスを50％下げるのに必要なエアゾ
ール化アデノシンのmg／ml濃度）を得て、これら動物についてオリゴヌクレオチ
ド曝露前に得たPC₅₀値と比較した。1週間後、動物を交換し、それまでミスマッ
チコントロールオリゴヌクレオチドを投与されていた動物にはアンチセンスオリ
ゴヌクレオチドが投与された。処置方法および測定は第一回目の実験と同一に行
われた。アンチセンスオリゴヌクレオチドで処理された8匹の動物中6匹について
は、アデノシン溶解限界値である20mg／mlまで、アデノシンを介した気管支収縮
は認められなかったことに注意すべきである。計算の目的のために、これらの動
物に関するPC₅₀値は、20mg／mlにセットされた。従って得られた値は、アンチセ
ンス有効性に関する最少値を表す。実際の有効性はより高かった。本実験の結果
を下table 5に示す。

【００４７】

【表６】

【００４８】 両実験では、アンチセンスオリゴヌクレオチドを投与された動物について、肺
の動的コンプライアンスを50％低下させるのに必要なエアゾール化アデノシン量
について大きな増加が認められた。ミスマッチコントロールオリゴヌクレオチド
は_PC50に対し効果を示さなかった。アンチセンスまたはコントロールのエアゾー
ルオリゴヌクレオチドを投与された動物について毒性は観察されなかった。これ
らの結果は肺疾患におけるアンチセンスオリゴヌクレオチドをベースとする臨床
的介入に関し、肺が標的として例外的な可能性を有していることを明瞭に示して
いる。更に結果は、ヒト喘息に極めて類似したモデルシステムにおいて、アデノ
シンA₁レセプターのダウンレギュレーションにより喘息気道のアデノシン介在型
気管支収縮が大きく排除されることも示している。ヒト喘息に関するアレルギー
ウサギモデルでの気管支過敏性は、この反応に関係する組織がエアゾール化され
たオリゴヌクレオチドと接触する位置近くに存在することから、アンチセンス介
入の優れたエンドポイントであり、このモデルは重要なヒト疾患について良くシ
ュミレートしている。

【００４９】 実施例4：（A₁−アデノシンレセプターアンチセンスオリゴヌクレオチドの特
異性） 上記実施例3のクロスオーバー実験の結論では、全てのウサギの気道平滑筋は
アデノシンA₁レセプター数に関し定量的に分析された。アンチセンスオリゴヌク
レオチドの特異性のコントロールとして、影響を受けることのないアデノシンA₂ レセプターについても定量した。気道平滑筋組織を各ウサギより切り取り、その
関連部分が参照され、その全体がここに取り込まれているKleinsteinら（Kleins
tein，J．およびGlossmann、H．，Naunyn−Schmiedeberg’s Arch．Pharmacol．
305：191−200（1978））を一部変更した方法に従い、膜分画を調製した。粗原
形質膜調製物はアッセイまで70ECにて保存された。タンパク質含有量はBradford
の方法（M．Bradford、Anal．Biochem．72，240−254（1976）、その関連部分が
参照され、ここにその全てが取り込まれている）いより決定された。凍結原形質
膜は室温にて融解され、0．2U／mlのアデノシンデアミナーゼと30分間、37ECに
てインキュベーションされ、内因性のアデノシンが取り除かれた。［³H］DPCPX
（A₁レセプター特異的）または［³H］CGS−21680（A₁レセプター特異的）の結合
はAlieらにより既述された如くにして測定された（Ali，Sら、J．Pharmacol．Ex
p．Ther．268，Am．J．Physiol 266，L271−277（1994）、その一部は参照され
その全てがここに取り込まれている）。クロスオーバー実験にてアデノシンA₁ア
ンチセンスオリゴヌクレオチドで処理された動物は、A₁特異的アンタゴニストDP
CPXの特異結合によりアッセイしたところ、コントロールに比べてA₁レセプター
は約75％減少した。A2レセプター特異的アゴニスト2−［p−（2−カルボキシエ
チル）−フェネチルアミノ］−5’−（N−エチルカルボキシアミド）アデノシン
（CGS−21680）の特異的結合によりアッセイした場合、アデノシンA₂レセプター
数に差は認められなかった。この結果は下table 6に示す。

【００５０】

【表７】

【００５１】 上記結果は、気道疾患処置におけるアンチセンスオリゴヌクレオチドの有効性を
例示している。上記のアンチセンスオリゴはアデノシン介在気管支収縮を担うレ
セプターシステムを排除することから、それらからのアデノシン排除に関する強
制性は低い。しかし、同様の効果を得るために必要とされる容量を減らすために
は、これらオリゴヌクレオチドからアデノシンを排除することが望ましいだろう
。上記は、炎症に関係するタンパク質のmRNAを標的とする別のアンチセンスオリ
ゴヌクレオチドである。アデノシンは、分解によるそれからの放出を阻止するた
めに、そのヌクレオチド成分より排除されている。

【００５２】 実施例5：（他の標的核酸に対するアンチオリゴヌクレオチド） 本作業は、本発明が核酸標的に対し特異的なアンチセンスオリゴヌクレオチド
（”オリゴ”）に広範囲に応用可能であることを示すために実施された。以下の
実験的研究は、発明の方法が本申請により教示される如くに設計され、そして一
部および全てのアデノシンレセプターmRNAを標的とするアンチセンスオリゴの利
用に広範に好適でることを示すために実施された。この目的に関し、アデノシン
A1、A2bおよびA3レセプターmRNAsにより例示される各種アンチセンスオリゴがア
デノシンレセプターmRNAに対し調製された。アンチオリゴIは上記に開示された
（配列番号1）。さらに5種類のアンチセンスホスホロチオネートオリゴが上記の
如くに設計され合成された。 1−オリゴII（配列番号7）もアデノシンA₁レセプターを標的とするが、オリゴI
とは異なる領域を標的とする。、 2−オリゴV（配列番号10）はアデノシンA_2bレセプターを標的とする。 3−オリゴIII（配列番号8）およびIV（配列番号9）はアデノシンA₃レセプターの
別領域を標的とする。 4−オリゴI−PD（配列番号1681）（オリゴI同様の配列のホスホジエステルオリ
ゴ）。

【００５３】 これらアンチセンスオリゴは、上記の如くの選択種に対する処置用に設計され
、一般に他種の標的mRNAの部分が偶然に同様の配列を含まない限りその種に特異
的である。いずれのアンチセンスオリゴも下記の如くに調製され、上記応用に記
した如く喘息様の症状としての呼吸困難および肺気道障害を有する、気管支収縮
、炎症およびアレルギーに関するウサギモデルにて、インビボで試験された。

【００５４】 実施例6：（他のアンチセンスオリゴの設計と配列） 6種類のオリゴおよびそのウサギモデルにおける作用を調べ、それら研究の結
果を以下報告し考察する。上記実施例1ないし4に提供されたオリゴI（配列番号1
）に関するデータを補うために、本研究ではこれらオリゴのうち5種類を選択し
た。このオリゴはアデノシンA₁レセプターmRNAの1領域に対するアンチセンスで
ある。試験されたオリゴは、アデノシンA₁レセプターmRNAの異なる領域を標的と
するアンチセンスオリゴI（配列番号1）およびII（配列番号7）でることが確認
され、オリゴV（配列番号8）はアデノシンA_2bレセプターmRNAを標的とし、アン
チセンスオリゴIIIおよびIV（配列番号9および10）はアデノシンA₁レセプターmR
NAの異なる2領域を標的とすることが明らかになった。6種類のオリゴ（オリゴI
−PD）はオリゴI（配列番号1）のフォスフォジエステル版である。これらアンチ
センスオリゴの設計と合成は上記実施例1に従い実施された。

【００５５】 （I）アンチセンスオリゴI 上記実施例1および4に参照されたアンチセンスオリゴヌクレオチドIはヒトA₁
アデノシンレセプターmRNA（EPI2010）を標的としている。アンチセンスオリゴI
は21ヌクレオチド長で、開始コドンに一致し、かつ以下の配列を有している；5
’−GAT GGA GGG GGG CAT GGC GGG−3’（配列番号1）。オリゴIはこれまで
にアレルギーウサギにおけるアデノシン−誘導気管支収縮を排除すること、上記
およびその関連部分が参照されその全体がここに取り込まれているNyce，J．W．
＆ Metzger，W．J．，Nature，385：721（1977）に示される様にアレルゲン誘
導の気道閉塞および気管支過敏症（BHR）を低下することがしめされている。

【００５６】 （II）アンチセンスオリゴII ホスホロチオネートアンチセンスオリゴ（配列番号7）は、発明により開始コ
ドン（開始部位）に対し＋936ないし＋956ウサギアデノシンA₁レセプターmRNAの
領域を標的として設計された。アンチセンスオリゴIIは21ヌクレオチド長で、以
下の配列を持つ：5’−CTC GTC GCC GTC GCC GGC GGG−3’（配列番号7）。

【００５７】 （III）アンチセンスオリゴIII 上記実施例Iに提供される以外のホスホロチオネートアンチセンスオリゴ（配
列番号8）は、発明により開始コドン開始部位に対し＋3ないし＋22のアンチセン
スA₃レセプターmRNA領域を標的として設計された。アンチセンスオリゴIIIは20
ヌクレオチド長で、以下の配列を持つ：5’−GGG TGG TGC TAT TGT CGG GC−
3’（配列番号8）。

【００５８】 （IV）アンチセンスオリゴIV さらに別のホスホロチオネートアンチセンスオリゴ（配列番号9）は発明によ
り、開始コドン（開始部位）に対し＋386ないし＋9401のアデノシンA₃レセプタ
ーmRNA領域を標的として設計された。アンチセンスオリゴIVは15ヌクレオチド長
で、以下の配列を持つ：5’−GGC CCA GGG CCA GCC−3’（配列番号9）。

【００５９】 （V）アンチセンスオリゴV ホスホロチオネートアンチセンスオリゴ（配列番号10）は発明により、開始コ
ドン（開始部位）に対し−21ないし−1のアデノシンA_2bレセプターmRNA領域を標
的として設計された。アンチセンスオリゴVは21ヌクレオチド長で、以下の配列
を持つ：5’−GGC CGG GCG AGC CGG GCC CGG−3’（配列番号10）。 （VI） A₁ミスマッチオリゴ 以下の配列を有する2種類のミスマッチ型オリゴヌクレオチドを上記実施例5記
載のアンチセンスオリゴ（配列番号1）のコントロールに用いた：A₁MM2；5’−G
TA GGT GGC GGG CAA GGC GGG−3’（配列番号2421）およびA₁MM3：5’−GAT
GGA GGC GGG CAT GGC GGG−3’（配列番号2422）。アンチセンスオリゴIおよ
び2種類のミスマッチアンチセンスオリゴは同一の塩基内容と一般構造を有して
いる。GENBANK（85．0版）およびEMBL（40．0版）での相同性検索は、アンチセ
ンスオリゴIがヒトだけでなくウサギのアデノシンA₁レセプターに対しても特異
的であること、そしてミスマッチ型コントロールはいずれの既知ヒトまたは動物
遺伝子配列ともハイブリダイゼーションに関する候補ではないことを示した。

【００６０】 （VII）アンチセンスオリゴA₁−PD（オリゴVI） オリゴIと同一ヌクレオチド配列を有するホスフォジエステルアンチセンスオ
リゴ（オリゴVI；配列番号2420）は上記応用に開示された如くに設計された。ア
ンチセンスオリゴI−PDは21ヌクレオチド長で、開始コドンを含み、以下の配列
を持つ：5’−GAT GGA GGG CGG CAT GGC GGG−3’（配列番号2420）。 III）コントロール 8匹のウサギに5，0mlのエアゾール化した滅菌生理食塩水を、上記（II）、（I
II）および（IV）のアンチセンスオリゴに関するスケジュールと同一に投与した
。

【００６１】 実施例7：（アンチセンスオリゴの合成） 上記（a）に記載の配列を有するホスホロチオネートアンチセンスオリゴは、
アプライドバイオシステムス（Applied Biosystems） モデル396 オリゴヌクレ
オチド合成装置にて合成され、NENSORBクロマトグラフィー（デュポン、デラウ
エア州）（DuPont、DE）を用い精製された。合成中、硫化剤としてTETD（テトラ
エチルチウラムジスルフィド）を用いた。本法にてアンチセンスオリゴヌクレオ
チドII（配列番号7）、アンチセンスオリゴヌクレオチドII（配列番号8）および
アンチセンスオリゴヌクレオチドIV（配列番号9）がそれぞれ合成され、精製さ
れた。

【００６２】 実施例8：（アレルギー性ウサギの準備） ニュージランド白色無パスツレラウサギを、関連部分が参照され、その全体が
ここに取り込まれている既報と同様に（Metzger、W．J．，in Late Phase All
ergic Reactions、Dorsch、W．，編集、CRC Handbook、pp．347−362，CRC Pres
s，Boca Raton（1990）；Ali， S．，Metzger，W．J．およびMustafa，S．J．
Am．J．Resp．Crit．Care Med．149：908（1994））出産24時間以内に10％カオ
リンと混合した312抗原単位／mlの家ダニ（D．Farinae）抽出物（バークレーバ
イオロジカルス、バークレー、カリフォルニア州（Berkeley Biologicals、Ber
keley、CA）0．5mlで免疫感作した。免疫感作は最初の1ヶ月間については毎週、
以後は2週おきに4ヶ月齢まで反復された。これらウサギは好ましくアレルゲン特
異的IgE抗体を産生し、エアロアレルゲンに対し初期および後期喘息反応の両方
を伴う典型的反応を示し、気管支過敏症（BHR）を起こした。毎月のアレルゲン
の腹腔内投与（上記同様、312単位の家ダニアレルゲン）は、アレルゲン特異的I
gE抗体およびBHRを刺激し、維持した。4月齢時に、感作したウサギを、関連部分
が参照されその全体がここに取り込まれているAliらの報告に従ってエアゾール
投与用に合わせ準備した（Ali， S．，Metzger，W．J．およびMustafa，S．J．
Am．J．Resp．Crit．Care Med．149：908（1994））。

【００６３】 用量−反応研究 実施例9：（実験準備） アデノシン（0−20mg／ml）またはアンチセンスもしくは2種類のミスマッチオ
リゴヌクレオチド（5mg．ml）の一方が、別々に超音波噴霧器（Moedel646，Devi
lbiss，Somerset，PA）を用い、エアゾール滴の80％が直径5：m以下に成るよう
に調製された。等量のエアゾールが、気管内チューブを通じ直接投与された。動
物部は無作為化され、エアゾール化されたアデノシンが投与された。アデノシン
に対する感受性に関する1日目の処置前値を、コンプライアンスの50％消失をも
たらすアデノシン用量として計算した（_PC50アデノシン）。次に動物にエアゾー
ル化されたアンチセンスまたはミスマッチアンチセンスオリゴの一方を気管無い
チューブを介して、2日間にわたり1日2回、2分間投与した（総投与量、20mg）。
処置前_PC50値を3日目の朝に記録した（処置前誘発）。これらの研究の結果は下
記実施例21に提供される。

【００６４】 実施例10：（クロスオーバー実験） アンチセンスオリゴI（配列番号1）および対応するミスマッチコントロールオ
リゴヌクレオチドA1MM2を用いた幾つかの実験に関し、2週間隔の後動物を交換し
、それまでミスマッチコントロールA₁MM2が投与された動物にはアンチセンスオ
リゴIを、それまでアンチセンスオリゴIが投与されていた動物にはミスマッチコ
ントロールA₁MM2オリゴが投与された。グループ毎の動物数は以下の通りである
。ミスマッチA1MM2（コントロール1）に関しては、技術的困難より実験の第2コ
ントロール中に1匹の動物をうしなったためn＝7であり、ミスマッチA₁MM3（コン
トロール2）はn＝4、そしてA₁ASアンチセンスオリゴIについてはn＝8であった。
交換後に用いた処置法および測定法は、第1実験のものに同一であった。アンチ
センスオリゴI（配列番号1）で処理された8匹中6匹で、アデノシンの溶解上限値
である20mg／mlまでのアデノシン投与量についてPC₅₀値が得られなかった。従っ
て、計算上これら動物のPC₅₀値は20mg／mlとした。従って得られた値は、発明の
アンチセンスオリゴヌクレオチドの有効性に関する最小値を表す。アレルギー性
ウサギの他のグループ（各グループ4匹ずつ）には、0．5または0．05mgのアンチ
センスオリゴI（配列番号1）またはA1MM2オリゴを上記様方法びスケジュールに
従い投与された（合計投与量は2．0または0．2mg）。これら研究の結果は下記実
施例22に提供される。

【００６５】 実施例11：（アンチセンスオリゴ製剤） 各アンチセンスオリゴは別々に水溶液に溶解され、上記同様に気管内チューブ
を開始噴霧器を利用して5mgずつ4回（合計投与量20mg）、上記（e）のアンチセ
ンスオリゴI（配列番号1）に関する記載同様に投与された。アンチセンスオリゴ
Iおよびそのミスマッチコントロールに関し得られた結果より、ミスマッチコン
トロールが下記実施例19およびNyceとMetzger、Nature385：721−725（1997）の
table 1に記載の如く、生理食塩水と等価であることが確認された。この発見よ
り、アンチセンスII、IIIおよびIV（配列番号7，8および9）を用いた肺機能試験
に関するコントロールとして生理食塩水を用いた。

【００６６】 実施例12：（アデノシンA1レセプターについてのオリゴIの特異性（レセプタ
ー結合試験）） 気道平滑筋の組織を上記の如くに48時間の間に20mgのオリゴI（配列番号1）を
4回に分けて投与されたウサギより主、二次および3次気管支より切除した。膜分
画はAliら（Ali S．，らAm．J．Resp．Crit．CareMed．149：908（1994）その関
連部分が参照され、その全体がここに取り込まれている）の方法に従い調製され
た。タンパク質含有量はBrafordの方法にて決定され、粗原形質膜は0．2U／mlの
アデノシンデアミナーゼと30分間、37ECにてインキュベーションされ、内因性の
アデノシンが取り除かれた。その関連部分が参照され、その全体がここに取り込
まれているBradford，M．M．Anal．Biochem．72，240−254（1976）を参照せよ
。［³H］DPCPX、［³H］NPC17731または［³H］CGS−21680の結合はJarvisらの報
告に従い測定された。その一部は参照され、その全てがここに取り込まれている
Jarvis，M．F．，ら、Pharmacol．Exp．Ther．251，888−893（1989）を参照せ
よ。本試験の結果はtable 8に示され、下記実施例20にて考察される。

【００６７】 実施例13：（肺機能測定（コンプライアンスC_DYNおよび抵抗性）） 4ヶ月齢の免疫した動物に1，5mlのケタミンHCl（35mg／kg）とアセプロマジン
マレイン酸（1．5mg／kg）の混合液を筋肉内投与し、麻酔、弛緩させた。麻酔導
入後、アレルギー性ウサギは柔らかく整形された動物用ボード上に快適に仰臥位
置に置かれた。乾燥防止の為に目に軟膏が塗られ、閉じられた。次に動物に4．0
mmの中間高−低カフ付きMurphy1型気管内チューブ（マリンクロット社、グレン
フォール、ニューヨーク（Mallinkrodt、Inc．，Glens Falls、NY））を、Zaval
aとRhodesによる報告通りに挿入した。その関連部分が参照され、その全体がこ
こに取り込まれているZavalaとRhodes、Proc．Soc．Exp．Biol．Med．144：509
−512（1973）を参照せよ。

【００６８】 附属の薄壁型ラテックスバルーンの付いたOD2．4mmのポリエチレン製カテーテ
ル（ベクトンディッキンソン、クレーアダムス、パリスパニー、ニュージャージ
ー（Becton Dickinson、Clay Adams、Parisppany NJ）を食道に通し、実験を
通じ口から同一距離（約16cm）に維持した。気管内チューブは加温されたフレイ
シュニューモタコグラフ（サイズ00：DOMメディカル、リッチモンド、バージニ
ア（DOM Medical、Richmond，VA））に接続され、流量（v）はゴールドキャリア
ー（Gould carrier）増幅器（モデル11−4113、ゴールドエレクトロニクス社、
クリーブランド、オハイオ（Gould Electronic、Cleveland、OH）により駆動さ
れるバリダイン差圧トランスデューサー（モデルDP−45−16−1927；バリダイン
エンジニアリング社、ノースリッジ、カリフォルニア（Validyne Engineering
Corp．，Northridge，CA））により測定された。食道バルーンは差圧トランスデ
ューサーの一方側に取り付けられ、気管内チューブの出口は圧トランスデューサ
ーの反対側に接続され、経肺圧（P_tp）が記録された。流量は積算されて連続し
た一回換気量が求められ、そして等容点および流量ゼロ点それぞれについて、総
肺抵抗性（R₁）および動肺コンプライアンス（C_dyn）の測定が行われた。流量、
容積および圧は8チャンネルゴールド2000W高周波レコーダーにより記録され、C_{d yn} はゼロ流量時の総容積およびP_tpの差を利用し計算され、そしてR_l は中央換
気肺容積時のP_tpおよびVの割合として計算された。これらの計算はBuxco自動肺
人工呼吸分析装置（モデル6，Buxco Electronics、Sharon、CT）を利用し、Gile
sらの報告に従い自動的に行われた。その関連部分が参照されその全体がここに
取り込まれているGilesら，Arch,Int．Pharmacdyn．Ther．194：213−232（1971
）を参照せよ。アレルギー性ウサギに関するオリゴIIの投与について得られた結
果は下記実施例26に示され、考察される。

【００６９】 実施例14：（気管支過敏性（BHR）の測定） 各8匹のアレルギー性ウサギにエアゾールによりヒスタミンが投与され、ベー
スラインの過敏性が決定された。生理食塩水またはヒスタミンのエアゾールはDe
libiss超音波噴霧器（DeVilbiss、Somerset、PA）にを30秒間利用して生成され
、続いて2分間各投与が実施された。超音波噴霧器はその80％が直径が5ミクロン
未満のエアゾール滴を生成した。ヒスタミンエアゾールは濃度を上げながら投与
され（0．156から80mg／ml）、各投与後に肺機能が測定された。次にベースライ
ン値よりC_dynを50％下げるのに必要なヒスタミン濃度（PC₅₀ヒスタミン）を計算
して、B4Rが決定された。

【００７０】 実施例15：（アンチセンスオリゴIの心臓血管作用） CardiomaxJを用いた心排出量およびその他の心臓血管パラメータの測定は、冷
生理食塩水の既知量を静脈注入した後の心臓から出る血液の温度の変化を記録す
る熱希釈の原理を利用している。右頸静脈のカニュレーションを通し右心房内に
冷生理食塩水の注入を1回行い、動脈弓内で混合された注入液と血液の温度変化
を、頸動脈のカニュレーションを介し温度センサーミニプローブにより記録した
。アレルギー性ウサギを上記（d）記載の如くにオリゴI（EPI2010；配列番号1）
で処理してから12時間後に、動物を80％ケタミンおよび20％キシラジン、0．3ml
／kgで麻酔した。この時点は、参照されここにその全体が取り込まれている適切
な公開物である、上記NyceとMetzger（1997）により明瞭に示されている様に、
配列番号Iに関する有効性を示すデータと一致している。次にサーモカップルが
各ウサギの左頸動脈に挿入され、続いて6．5cm進められ絹縫合糸にて固定された
。続いて右頸静脈にカニュレーションが行われ、ある長さのポリエチレンチュー
ブが挿入され固定された。次に20ECの生理食塩水が注入され、CardiomaxJ II（
Columbus Instruments、Ohio）により熱希釈曲線が確立され、サーモカップル
プローブの位置の正確性が決定された。サーモカップルの位置が正確であること
が決定した後、大腿動脈および静脈が分離された。大腿静脈は薬物注入口として
利用され、大腿動脈は血圧および心拍数の測定に利用された。安定したベースラ
イン心臓血管パラメータが確立した後、血圧、心拍数、心排出量、総末梢抵抗、
および心臓収縮性に関するCardiomaxJ測定が行われた。

【００７１】 実施例16：（オリゴI（配列番号I）の作用持続時間） 8匹のアレルギー性ウサギに上記（f）記載の如くに気管内チューブを開始、噴
霧器を利用してアデノシンを0．156mg／mlからコンプライアンスが50％低下する
（PC_50Adenosine）までまず対数用量的に増加させながら投与し、ベースライン
を確立した。次に6匹のウサギに上記の様に（配列番号I）の5mgのエアゾール投
与を4回行った。2匹のウサギには等量の生理食塩水をコントロールとして投与し
た。最後の処置から18時間後にPC₅₀アデノシンを再度試験した。この時点の後10
日間まで、毎日全ての動物について測定を継続した。本試験の結果は下記実施例
25に考察する。

【００７２】 実施例17：（アンチセンスオリゴVによるアデノシンA_2bレセプター数の減少） Sprague Dawleyラットに、上記同様に吸入チャンバーを利用して、2日間3回、
2．0mgの吸入可能なアンチセンスオリゴV（配列番号10）を投与した。最終投与1
2時間後に、肺実質組織を切り取り、アデノシンA_2bレセプター結合について上記
NyceとMetzger（1997）に従い［311］−NECAを利用しアッセイした。コントロー
ルは、等量の生理食塩水を投与し行った。結果は、スチューデントの対t試験を
利用し有意差レベルp＜0．05にて実施し、下記実施例28に考察する。

【００７３】 実施例18：（オリゴIと対応するホスフォジエステルオリゴVI（配列番号1681
の比較）） オリゴI（配列番号I）はアデノシンの影響を受けるが、20mgアデノシン／5ml
までのアデノシン量（アデノシンの溶解性の限界）に関してはそれに対する感受
性を排除した。このオリゴヌクレオチド配列のホスフォジエステル版であるオリ
ゴVI（配列番号1681）は、同様の方法で試験したところ完全に無効となった。両
化合物は同一の配列を有し、唯一の差はオリゴI（配列番号1）中のホスホロチオ
ネート残基の存在であり、上記、および上記NyceとMetzger（1997）記載の如く
にエアゾールとして供給された。有意差はスチューデント対t試験でp＜0．001で
あった。結果は下記実施例29にて考察される。

【００７４】 アンチセンスオリゴI（配列番号I）に関し得られた結果 実施例19：（先の実験結果） アデノシンA₁レセプターに特異的であるアンチセンスオリゴI（配列番号1）に
関するヌクレオチド配列およびその他のデータは上記に提供された。レセプター
数および活性のダウンレギュレーションにおけるオリゴIの有効性を示す実験デ
ータも上記に提供された。アンチセンスオリゴIの特徴および活性に関するその
他の情報Nyce，J．W．およびMetzger、W．J．，Nature 385：721（1997）に提
供されており、以下の結果に関連する関連部分は、参照されここにその全体が取
り込まれている。NyceとMetzger（1997）の発表は、アンチセンスオリゴI（配列
番号I）を示すデータを提供する： （1）アンチセンスは下table 5に見て取れる様に用量依存的にアレルギー性ウサ
ギの気道平滑筋におけるアデノシンA₁レセプターの数を減少させる。 （2）アンチセンスオリゴIはアデノシン誘導気管収縮およびアレルゲン誘導気管
収縮を減弱する。 （3）オリゴIは気管過敏性を評価する標準的検査法であるPC₅₀ヒスタミンにより
測定される気管過敏症を減弱する。この結果は上table 5に示される様に、アン
チセンスオリゴIの抗炎症活性を明瞭に示している。 （4）それを標的に設計されたことから予想される様に、アンチセンスオリゴIは
完全にアデノシンA₁レセプターに対し特異的であり、いずれの用量に関しても密
接に関連するアデノシンA₂レセプター、または関連するブラジキンB₂レセプター
のいずれに対しても全く影響を及ぼさない。 （5）アンチセンスオリゴI（配列番号I）と同一の組成および分子量を有するが
、6および2個のミスマッチにより異なるミスマッチコントロール分子MM2およびM
M3（配列番号1682および配列番号1683）は、上記オリゴIとは対照的である。こ
れらミスマッチはまだ同一のベース組成は保持し可能性はあるものの、標的レセ
プター（A₁、A₂またはB₂）のいずれに対しても完全に影響を及ぼさない。

【００７５】 これらの結果は、アデノシンA1レセプターを標的とするオリゴIのな様アンチ
センスオリゴヌクレオチドの利用に関する従来技術が全くないことと合わせ、予
想外の結果であった。本特許中に提示された結果はその目的とする利用に関し、
クレームの作用物質、および気管収縮、炎症、アレルギー等の様な肺気道に関す
る病気および状態の処置に関する方法の有効性を明瞭に示した。

【００７６】 実施例20：（オリゴIはアデノシンチャレンジに対する応答を明瞭に低下させ
る） レセプター結合実験は上記実施例12に既述され、table 5に示された結果は、
アデノシンA₁レセプターおよびB2ブラジキニンレセプターアンチセンスおよびミ
スマッチで処理されたアレルギーウサギの気道平滑筋より分離された膜内での、
アデノシンA₁レセプターリガンド［₃H］DPCPXおよびブラジキンB₂選択リガンド
［³H］NPC17731の結合特性を示す。

【００７７】

【表８】

【００７８】 実施例21： オリゴIの用量−応答効果 アンチオリゴI（配列番号1）は、下table 6に示す如く試験した投与量範囲にお
いて用量依存的様式にて動物に対するアデノシン投与の効果を減じることが判明
した。

【００７９】

【表９】

【００８０】 オリゴI（配列番号1）、アンチアデノシンA₁レセプターオリゴは特異的にアデ
ノシンA₁レセプターに作用するが、アデノシンA₂レセプターには作用しない。こ
れらの結果は、実施例9記載およびNyceとMetzger（1997）上記（8ないし12時間
の間隔を開け、噴霧器を使い気管内チューブを介し5mgを4回投与）に既述の如く
、アンチオリゴI（配列番号I）またはミスマッチコントロールオリゴ（配列番号
1682；A₁MM2）により処理されたウサギより切り出された気管平滑筋組織にし、
そしてアデノシンA₁およびアデノシンA₂レセプターの数はNyceとMetzger（1997
）上記、の報告に従い決定された。する。

【００８１】 実施例22：（標的遺伝子産物に関するオリゴI（配列番号I）の特異性） オリゴI（配列番号I）は、アデノシンA1レセプターに対し特異的であるが、一
方そのミスマッチコントロールは活性を持たなかった。図1は上記実施例10およ
びにNyceとMetzger（1997）上記に記載のクロスオーバー実験より得た結果を示
す。2種類のミスマッチコントロール（配列番号1682および配列番号1683）はPC_{5 0} アデノシンに影響を示さなかった。これに対し、アンチセンスオリゴI（配列番
号I）はPC₅₀アデノシン値を数倍増加させた。結果はアンチセンスオリゴI（配列
番号I）が生理食塩水コントロールに比べると）外来性に投与されたアデノシン
に対する反応を低下させる（感受性の減弱化）ことを明瞭に示す。上table 6の
結果は、アンチセンスオリゴIの効果が用量依存的であることを明瞭に確立した
（table 5のカラム3を参照）。オリゴIもまたアデノシンA₁レセプターに対し完
全に特異的であり（table の上3列を参照）、密接に関連したアデノシンA₁レセ
プターまたはブラジキンB₂レセプターにも活性を誘導しないことが確立された（
上記table 6の8−10列参照）。更に、table 6に示された結果は、アンチセンス
オリゴI（配列番号1）が用量依存的にアデノシンに対する感受性を低下させるこ
と、そして2種類のミスマッチコントロールオリゴヌクレオチド（A₁MM2；配列番
号1682およびA₁MM3；配列番号1683）がPC₅₀アデノシン値に影響しないこと、あ
るいはアデノシンA₁レセプターの数の低下にも影響しないことから、これがアン
チセンスオリゴ−依存的な様式にておこることも確立した。

【００８２】 実施例23：（エアロアレルゲン誘導気管支収縮および炎症への効果） オリゴI（配列番号1）はミスマッチオリゴに比較し、ウサギモデルでのヒスタ
ミン誘導を明瞭に低下することが示された。アンチセンスオリゴI（配列番号1）
およびミスマッチオリゴ（A₁MM2；配列番号1682およびA₁MM3；配列番号1683）の
アレルゲン誘導気道閉塞および気管支過敏反応に及ぼす効果を、アレルギー性ウ
サギを使い評価した。アレルゲン誘導気道閉塞に及ぼアンチセンスオリゴI（配
列番号1）の効果を調べた。プロットされた曲線下の面積より計算すると、ミス
マッチコントロールに比べアンチセンスオリゴIは明瞭にアレルゲン誘導気道閉
塞を阻害した（55％、p＜0．05；反復測定ANOVA、およびTukeyのt試験）。ミス
マッチオリゴA₁MM2（コントロール）では、アレルゲン誘導気道収縮に対し完全
な効果消失が誘導された。アンチセンスオリゴI（配列番号1）のアレルゲン誘導
BHRに対する効果は上記同様にして決定された。PC₅₀ヒスタミン値より計算した
ところ、アンチセンスオリゴI（配列番号1）は、ミスマッチコントロールに比べ
明瞭にアレルゲン誘導BHRを阻害した（61％、p＜0．05；反復測定ANOVA、および
Tukeyのt試験）。アレルゲン誘導BHRに対するミスマッチオリゴA₁MMコントロー
ルの効果の完全消失が観察された。結果はアンチセンスオリゴI（配列番号1）は
、吸入アレルゲン誘導気管支種縮（イエダニ）に対する防御に有効であることを
示した。更に、そのヒスタミン感受性に対しても有効であり、アンチセンスオリ
ゴI（配列番号1）に抗炎症活性が示されたことから、アンチセンスオリゴI（配
列番号1）はイエダニ誘導気管支過敏症の強力な阻害剤であることも見いだされ
た。

【００８３】 実施例24：（アンチセンスオリゴI（配列番号1）には重大な副作用が無い） アンチセンスオリゴI（配列番号1）は宿主に対し有毒となる副作用が無いこと
が示された。2．0または20mgのオリゴI（配列番号1）を投与した後も、動脈血圧
、心臓拍出量、駆出量、心拍数、総末梢抵抗、または心臓収縮性（dPdT）に変化
は観察されなかった。更にCardiomaxJ装置（コロンバスインスツルメント、オハ
イオ）を利用し心拍出量（CO）、駆出量（SV）、平均血圧（MAP）、心拍数（HR
）、総末梢抵抗（TPR）および収縮性（dPdT） を調べた。これらの結果は、オリゴI（配列番号1）が重要な心臓血管パラメータ
に対し有害な効果を持たないことを示した。より具体的には、このオリゴは血圧
低下を起こさない。この発見は、過去ホスホロチオネートアンチセンスオリゴヌ
クレオチドが幾つかのモデルにおいて血圧低下を誘導したことから、特に重要で
ある。更にアデノシンA₁レセプターは心臓内の洞房伝導に重要な役割を果たして
いる。従ってアンチセンスオリゴI（配列番号1）によるアデノシンA1レセプター
の減弱は、レセプターのダウンレギュレーションに反応する重篤な肺外活動を引
き起こすと予想されていた。これは生じなかった。アンチセンスオリゴI（配列
番号1）はいずれの重篤肺内効果も起こさず、そして予想外の、望しくない副作
用を認めないアンチセンスオリゴの低用量投与を提供する。このことは、アンチ
センスオリゴI（配列番号1）が肺に直接投与されること、それが心臓に重大な悪
影響を及ぼさないことを意味する。これはテオフィリンの様な従来のアデノシン
レセプターアンタゴニストが肺を回避し、時に生命を危険にする様な重大な有害
作用を及ぼすことがあることと好対照をなす。

【００８４】 実施例25：（オリゴIの長期ラスティング効果） PC₅₀およびアデノシン処置を受ける前に投与した場合の抵抗値より、オリゴI
（配列番号1）が長期間持続して有効であることが明らかになった。作用期間は
、上記同様に気管内チューブを開始噴霧器を使い、5mgづつ4回等量投与した場合
のアデノシンアンチセンスオリゴ1のPC₅₀に関し測定された。作用物質の効果は
投与後1ないし8日間明瞭であった。アンチセンスオリゴI（配列番号I）の効果が
消えた時点で動物には生理食塩水エアゾール（コントロール）が投与され、全て
の動物についてPC₅₀アデノシンカ゛測定された。生理食塩水処理動物は、ベースラ インのPC₅₀アデノシン値を示した（n＝6）。作用期間（抵抗性に関して）は、20
mgのアンチセンスオリゴI（配列番号I）を上記同様に投与された6匹のアレルギ
ー性ウサギについて、やはり上記同様に気道抵抗を測定し測定された。作用期間
の平均計算値は、PC₅₀アデノシン（p＜0．05）および抵抗（p＜0．05）について
共に8．3日であった。これらの結果は、アンチセンスオリゴI（配列番号I）は完
全に予想外の極めて長い作用期間を持っていることを示している。

【００８５】 実施例26：（アンチセンスオリゴII） アデノシンA₁レセプターmRNAの別の領域を標的とするアンチセンスオリゴIIは
、アデノシンA₁レセプター介在作用に対し極めて活発であることが示された。実
験では20mgのアンチセンスオリゴIIまたは生理食塩水（コントロール）を上記同
様のアレルギー性ウサギの2群に投与した時の、コンプライアンスおよび抵抗値
に及ぼすアンチセンスオリゴII（配列番号7）投与の効果を測定した。コンプラ
イアンスおよび抵抗値は、上記実施例13に記載の通りにアデノシン、または生理
食塩水投与後測定された。発明のアンチセンスオリゴの作用はコントロールと対
t試験においてコンプライアンスについてはp＜0．05、抵抗性についてはp＜0．0
1で統計有意に異なっていた。結果は、アデノシンA₁レセプターを標的とするア
ンチセンスオリゴII（配列番号7）はコンプライアンスを効果的に維持し、アデ
ノシン処置時の抵抗を低下させる。

【００８６】 実施例27：（アンチセンスオリゴIIIおよびIV） 上記のアレルギー性ウサギに対し20mgのアンチセンスオリゴIII（配列番号8）
およびアンチセンスオリゴIV（配列番号9）を別々に投与すると、炎症および存
在する炎症性細胞の減少にそれらが効果を示すことから、オリゴIII（配列番号8
）およびIV（配列番号9）が実際にアデノシンA₃レセプターを特異的に標的とし
ていることが示された。炎症細胞の数は、3時間後に気管支洗浄洗浄液当たり少
なくとも100個の生細胞を測定することで、気管支洗浄液中について決定された
。顆粒球および気管支洗浄液中の総細胞数に対するアンチセンスオリゴIII（配
列番号8）およびアンチセンスオリゴIV（配列番号9）の作用は、家ダニアレルゲ
ンに曝露した後に調べた。結果は、アンチセンスオリゴIII（配列番号8）および
アンチセンスオリゴIV（配列番号9）が家ダニアレルゲン曝露後の喘息性肺にお
いて極めて強力な抗炎症剤であることを示した。当分野既知の如く、顆粒球、特
に好酸球は喘息の一次炎症細胞である、そしてアンチセンスオリゴIII（配列番
号8）およびアンチセンスオリゴIV（配列番号9）の投与はこれら細胞の数をそれ
ぞれ40％および66％減少させた。更にアンチセンスオリゴIV（配列番号9）およ
びアンチセンスオリゴIII（配列番号8）は、気管支洗浄液中の総細胞数もそれぞ
れ40％および80％減少させた。これは発明の本抗アデノシンA₃作用物質による抗
炎症活性に関する重要な指標である。炎症は喘息における気管支過敏症およびア
レルゲン誘導気管支収縮の基礎をなすことが知られている。アデノシンA₃レセプ
ターを標的とするアンチセンスオリゴIII（配列番号8）およびアンチセンスオリ
ゴIV（配列番号9）は、各種の肺レセプターを特異的に標的とする様に設計され
る抗炎症剤の重要な新分類の例示である。

【００８７】 実施例28：（アンチセンスオリゴV） アデノシンA_2bアデノシンレセプターmRNAを標的とするアンチセンスオリゴV（
配列番号10）はアデノシンA_2bが関係する効果に極めて効果的であり、存在する
アデノシンA_2bセプタープターの数を約半数まで減少させることが示された。

【００８８】 実施例29：（ホスホジエステル−残基オリゴI−DS（配列番号1681）に対する
置換体の予想外の優越性） オリゴI（配列番号1）およびI−DS（配列番号1681）を別々に上記アレルギー
性ウサギに投与し、続いてウサギにアデノシンを作用させた。フォスフォジエス
テルオリゴI−DS（配列番号1681）は、アデノシンの作用に対し統計有意に低効
果であったが、オリゴI（配列番号1）は20mgのPC₅₀アデノシンに示される如くに
高い有効性を示した。

【００８９】 実施例30：（アンチセンスオリゴVI） 本研究に関して、アデノシンA1レセプターを標的とした別のアンチセンスホス
ホロチオネートオリゴ（オリゴVI）を設計した。このアンチセンスオリゴは上記
特許申請の中に記された様な選択種に対する処置を目的に設計されており、選択
された他種のアデノシンレセプターmRNAの断片が偶然にも同様配列を有しない限
りは、一般にその種に対し特異的である。アンチセンスオリゴは上記同様に調製
され、上記出願に記された如くに喘息等の病気の様に呼吸困難ならびに肺気道障
害を持つ、気管支収縮、炎症および肺アレルギーに関するウサギモデルにおいて
インビボにて試験された。別のオリゴおよびそのウサギモデルでの作用について
研究し、研究の結果を以下報告、考察する。本オリゴ（アンチセンスオリゴVI）
は、上記特許出願中に提供されるアデノシンA₁レセプターmRNAに対するアンチセ
ンスである配列番号1（オリゴI）に関するデータを補う本研究に合わせて選択さ
れた。この追加オリゴはアンチセンスオリゴVIと認定され、オリゴIとは異なる
アデノシンA₁レセプターmRNAの別領域を標的とする。 このアンチセンスオリゴの設計と合成は、上記特許出願、具体的には実施例1の
教示に従い実施された。アンチセンスオリゴVIは、開始コドン（開始位置）に対
し＋964から＋984のウサギアデノシンA₁レセプターmRNA領域のコーディング領域
を標的とする様に設計されたホスホロチオネートである。オリゴVIは上記出願中
に記されたように調製され、20ヌクレオチド長である。オリゴVIは、アデノシン
A₁レセプター遺伝子に向けられており、以下の配列を有する：5’−CGC CGG CG
G GTG CGG GCC GG−3’（配列番号＿）。上記（5）に既述された配列を有する
ホスホロチオネートアンチセンスオリゴVIはアプライドバイオシステムモデル39
6オリゴヌクレオチド合成装置にて合成され、NENSORBクロマトグラフィー（デュ
ポン、メリーランド州）（DuPont、MD）を用い精製された。合成中、硫化剤とし
てTETD（テトラエチルチウラムジスルフィド）を用いた。

【００９０】 実施例31：（アレルギー性ウサギの準備） 前記同様、ニュージランド白色無パスツレラウサギの新生児を、出産24時間以
内に10％カオリンと混合した312抗原単位／mlの家ダニ（D．farinae）抽出物（
バークレーバイオロジカルス、バークレー、カリフォルニア州（Berkeley Biol
ogicals、Berkeley、CA）0．5mlで免疫感作した（Metzger、W．J．，in Late
Phase Allergic Reactions、Dorsch、W．，編集、CRC Handbook、pp．347−362
，CRC Press，Boca Raton（1990）；Ali， S．，Metzger，W．J．およびMusta
fa，S．J．Am．J．Resp．Crit．Care Med．149：908（1994））。免疫感作は最
初の1ヶ月間については毎週、以後は2週おきに4ヶ月齢まで反復された。これら
ウサギは好ましくアレルゲン特異的IgE抗体を産生し、エアロアレルゲンに対し
初期および後期喘息反応の両方を伴う典型的反応を示し、気管支過敏症（BHR）
を起こした。毎月のアレルゲンの腹腔内投与（上記同様、312単位の家ダニアレ
ルゲン）は、アレルゲン特異的IgE抗体およびBHRを刺激し、維持した。4月齢時
に、感作したウサギは上記Aliらの報告（1994）に従い、エアゾール投与用に合
わせ準備された。

【００９１】 実施例32：（アデノシンエアゾール調剤） アデノシンエアロゾール（20mg／ml）は、、その80％が5：m以下の直径である
エアロゾール滴を生ずる超音波噴霧器（モデル646，DeVilbiss、Somerset、PA）
を用い調製された。等量のエアロゾールが3匹全てのウサギに対し、気管内チュ
ーブを通し肺に直接投与された。次に動物にはエアゾール化されたアデノシンが
投与され、アデノシンに対する感受性に関する1日目の処置前値を50％のコンプ
ライアンス消失を起こすアデノシン投与量として計算された（PC₅₀アデノシン）
。続いて2日間、1日2回、2分間（5mg／1．0ml）（合計投与量20mg）エアゾール
化されたアンチセンスが気管内チューブを通じ動物に投与された。処置後のPC₅₀ 値（処置後処置）は3日目の朝に記録された。これら試験の結果は以下（9）に示
される。

【００９２】 実施例33：（アンチセンスオリゴ製剤） アンチセンスオリゴはそれぞれ別々に溶液中に溶解され、上記（e）のアンチ
センスオリゴIの場合同様に、上記の如く気管内チューブを通し、噴霧器をつか
って5mgづつ4回（合計20mg）投与された。

【００９３】 実施例34： オリゴVIはアデノシン処置に対する応答をオリゴIと同等、また
はそれ以上低下させた。 オリゴVIは上記（7）および上記特許出願中に既述された様な特徴を持つアレ
ルギー性ウサギを用い試験された。オリゴVIはオリゴIとは異なるA₁レセプター
のコーディング域の一部を標的としている。これらの両標的配列は多くの可能な
コーディング域標的配列から無作為に選択された。3匹のウサギはオリゴIの場合
と同一に処理された。簡単に述べると、オリゴVIは2日間、1日2回、8時間の間隔
をあけてウサギに噴霧された。その後、PC₅₀アデノシン試験を3日目の朝に行い
、処置前PC₅₀値と比較した。このプロトコールはNyceと Metzger（Nyce＆Metzg
er，Nature，385：721（1977）に詳しく既述されている。3匹のウサギについて
得られた結果を下table 7に示す。

【００９４】

【表１０】

【００９５】 table 7に示すように、オリゴVIで処理された3匹全ての動物は、作用物質に対
する測定可能レベルまでアデノシンに対する感受性を排除した。これは、この3
匹のアレルギー性ウサギではオリゴVIがアデノシン誘導気管支収縮を排除するこ
とを意味する。従って、オリゴVIの実際の作用は、用いた実験システムで測定で
きる以上のものである。オリゴIについて得られている結果と比べると、オリゴV
IがオリゴIと同等またはそれ以上効果的であることが分かる。

【００９６】 実施例34：（結論） 実施例内に記載した研究および考察された結果は、上記出願の教示に従い設計
された全てのアンチセンスオリゴヌクレオチドが、それらが標的とするレセプタ
ーを開始伝達される作用に対抗し、あるいは低下させることに極めて有効である
ことを明瞭に示した。即ち、アデノシンA₁レセプターmRNAを標的とする2種類の
アンチセンスオリゴ、アデノシンA_2bレセプターmRNAを標的とする1種類のアンチ
センスオリゴ、およびA₃レセプターmRNAを標的とする2種類のアンチセンスオリ
ゴの全てが、それらが標的とする特異的レセプターを開始伝達される外来性に投
与されたアデノシンの作用に反対できることが示された。発明のアンチセンスオ
リゴは、更に標的に特異的であり、実質的に別の標的を阻害することはない。更
に、示された結果は本作用物質の投与には有害な副作用または毒性が極めて低い
か、または無いことも示している。このことは、気管支収縮および／または炎症
の処置に極めて有効であり、かつ特異的である作用物質を提供することが100％
可能であることを示している。本発明は気道疾患に関係する、または不随するタ
ンパク質をコードする全ての遺伝子、および対応するmRNAsに対し同様に広範に
応用可能であ。フォスフォジエステルと、フォスフォジエステル結合がホスホロ
チオネート結合に置換された同一オリゴヌクレオチドとの比較より、ホスホチオ
ネートオリゴヌクレオチドがフォスフォジエステルアンチセンスオリゴに比べ予
想外にも優れていることを実証した。

【００９７】 実施例35：（オリゴI前処理有／無でのアデノシンチャレンジに対するインビ
ボ応答） 2匹の高反応性サル（回虫感受性）に、アンチセンスオリゴ（配列番号1）によ
る前処理有り無しでアデノシンを吸引させ、作用させた。集めたデータよりPC₅₀ アデノシンを、高反応性気道での動的コンプライアンス中に40％の減少をもたら
すアデノシンmg量に等しいものとして計算した。オリゴI（配列番号1；EPI2010
）は2日間、吸入により10mg／ml連続して投与された。3日目にPCアデノシンを再
度測定した。オリゴI処置前のPC₅₀アデノシン値とオリゴI投与後のPC₅₀アデノシ
ン値とを1対1で比較した（図未提示）。2匹の動物で実施された結果は、1匹のサ
ルではアデノシンに対する感受性が本発明のオリゴの投与により完全に排除され
、もう一匹の動物でも本質的に減少したことが示された。

【００９８】 実施例36：（実験結果の拡大） 本発明の方法は、肺における各種状態の処置に関し、実質的に上記と同じ方法
により、上記の遺伝子、mRNAsおよび対応するタンパク質を標的とするアンチセ
ンスオリゴヌクレオチドを利用し実施することができる。その様な例は、ヒトA2
aアデノシンレセプター、ヒトA2bアデノシンレセプター、ヒトIgEレセプターβ
、ヒトFcエプシロンレセプターCD23抗原（IgEレセプター）、ヒトIgEレセプター
、アルファサブユニット、ヒトIgEレセプター、FcエプシロンR、ヒトヒスチジン
デカルボキシラーゼ、ヒトベータトリプターゼ、ヒトトリプターゼ−I、ヒトプ
ロスタグランジンD合成酵素、ヒトシクロオキシゲナーゼ−2、ヒト好酸球カチオ
ン性タンパク質、ヒト好酸球由来ニューロトキシン、ヒト好酸球ペルオキシダー
ゼ、ヒト細胞内接着分子1（CAM−1）、ヒト血管細胞接着分子1（VCAM−1）、ヒ
ト内皮細胞白血球接着分子（ELAM−1）、ヒトPセレクチン、ヒト内皮細胞単核球
活性化因子、ヒトIL3、ヒトIL4、ヒトIL5、ヒトIL6、ヒト単球由来好中球走化性
因子、ヒト好中球エラスターゼ（メデュラスチン）、ヒト好中球オキシダーゼ因
子、ヒトカテプシンG、ヒトデフェンシン1、ヒトデフェンシン3、ヒトマクロフ
ァージ炎症タンパク質−1−アルファ、ヒトムスカリン様アセチルコリンレセプ
ターHM1、ヒトムスカリン様アセチルコリンレセプターHM3、ヒトフィブロネクチ
ン、ヒトインターロイキン8、ヒトGM−CSF、ヒト主要壊死因子α、ヒトロイコト
リエンC4合成酵素、ヒト主要塩基性タンパク質、およびその他多数である。

【００９９】 上記実施例は本発明の例示であり、それを限定するものとして解釈されてはな
らない。本発明は、請求の範囲と、その中に含まれる請求の範囲の均等物により
解釈される。

【配列表】

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.⁷ 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 9/127 Ａ６１Ｋ 9/127 9/14 9/14 9/28 9/28 9/48 9/48 9/70 ４０１ 9/70 ４０１ 9/72 9/72 31/7088 31/7088 38/43 45/00 45/00 Ａ６１Ｐ 1/00 Ａ６１Ｐ 1/00 9/12 9/12 11/00 11/00 11/06 11/06 11/08 11/08 29/00 29/00 31/04 31/04 35/00 35/00 35/02 35/02 37/08 37/08 Ｃ１２Ｎ 1/15 ＺＮＡ Ｃ１２Ｎ 1/15 ＺＮＡ 1/19 1/19 1/21 1/21 5/00 Ａ 5/10 Ａ６１Ｋ 37/48 (81)指定国 ＥＰ(ＡＴ，ＢＥ，ＣＨ，ＣＹ， ＤＥ，ＤＫ，ＥＳ，ＦＩ，ＦＲ，ＧＢ，ＧＲ，ＩＥ，Ｉ Ｔ，ＬＵ，ＭＣ，ＮＬ，ＰＴ，ＳＥ)，ＯＡ(ＢＦ，ＢＪ ，ＣＦ，ＣＧ，ＣＩ，ＣＭ，ＧＡ，ＧＮ，ＧＷ，ＭＬ， ＭＲ，ＮＥ，ＳＮ，ＴＤ，ＴＧ)，ＡＰ(ＧＨ，ＧＭ，Ｋ Ｅ，ＬＳ，ＭＷ，ＳＤ，ＳＬ，ＳＺ，ＴＺ，ＵＧ，ＺＷ )，ＥＡ(ＡＭ，ＡＺ，ＢＹ，ＫＧ，ＫＺ，ＭＤ，ＲＵ， ＴＪ，ＴＭ)，ＡＬ，ＡＭ，ＡＴ，ＡＵ，ＡＺ，ＢＡ， ＢＢ，ＢＧ，ＢＲ，ＢＹ，ＣＡ，ＣＨ，ＣＮ，ＣＵ，Ｃ Ｚ，ＤＥ，ＤＫ，ＥＥ，ＥＳ，ＦＩ，ＧＢ，ＧＤ，ＧＥ ，ＧＨ，ＧＭ，ＨＲ，ＨＵ，ＩＤ，ＩＬ，ＩＮ，ＩＳ， ＪＰ，ＫＥ，ＫＧ，ＫＰ，ＫＲ，ＫＺ，ＬＣ，ＬＫ，Ｌ Ｒ，ＬＳ，ＬＴ，ＬＵ，ＬＶ，ＭＤ，ＭＧ，ＭＫ，ＭＮ ，ＭＷ，ＭＸ，ＮＯ，ＮＺ，ＰＬ，ＰＴ，ＲＯ，ＲＵ， ＳＤ，ＳＥ，ＳＧ，ＳＩ，ＳＫ，ＳＬ，ＴＪ，ＴＭ，Ｔ Ｒ，ＴＴ，ＵＡ，ＵＧ，ＵＳ，ＵＺ，ＶＮ，ＹＵ，ＺＷ Ｆターム(参考） 4B065 AA90X AA90Y AB01 BA02 CA23 CA44 4C076 AA01 AA03 AA06 AA09 AA11 AA16 AA17 AA22 AA24 AA29 AA36 AA43 AA53 AA72 AA93 AA94 BB01 BB11 BB12 BB13 BB15 BB16 BB22 BB25 BB27 BB29 BB30 BB31 BB32 CC04 CC10 CC15 CC27 FF16 FF34 FF39 FF51 FF53 FF61 4C084 AA13 AA19 MA01 MA02 MA13 MA17 MA22 MA23 MA27 MA28 MA31 MA32 MA35 MA36 MA37 MA43 MA52 MA56 MA57 MA58 MA59 MA60 MA63 MA65 MA66 MA67 NA12 NA14 ZA362 ZA422 ZA592 ZA611 ZA612 ZA662 ZB112 ZB132 ZB262 ZB272 ZB352 4C086 AA01 AA02 EA16 MA01 MA02 MA04 MA13 MA17 MA22 MA23 MA27 MA28 MA31 MA32 MA35 MA36 MA37 MA43 MA52 MA56 MA57 MA58 MA59 MA60 MA63 MA65 MA66 MA67 NA12 NA14 ZA36 ZA42 ZA59 ZA66 ZB11 ZB13 ZB15 ZB26 ZB27 ZB35 【要約の続き】 ともできる。薬剤、組成物および調合物は、呼吸障害、 肺アレルギーおよび／または炎症、ならびに肺血管収 縮、炎症、アレルギー、アレルギー性、喘息、呼吸困 難、肺痛、嚢胞性線維症、気管支収縮のような、肺サー ファクタント涸渇、およびサーファクタント生成欠如と 関連する病気の予防的、防御的、および治療的治療のた めに用いられる。本発明は、例えば、その他にもいろい ろあるが、照射、化学療法、抗体療法、および外科手術 を含む、その他の治療前、治療中および後の、その他の 治療と組み合わせての投与に適している。代わりに、本 薬剤は、それ自身が既知の治療を行わない状態に、また は望ましくない副作用を示す治療の代わりとして、予防 的または治療的に有効に投与される。本発明の治療を、 直接患者の呼吸系内に投与することができ、そうするこ とによって、薬剤は、病気の症状を軽減または阻害する ために効果的な量で、直接的に肺に、または、例えば、 局所、経皮 、移植等の、その他の有効な投与経路によ って、接近しうる。

Claims (91)

【特許請求の範囲】
1. 【請求項１】 哺乳類に投与されたときに、気管支収縮および／または肺炎
   、アレルギー、またはサーファクタント枯渇もしくは分泌不全を緩和するのに効
   果的なオリゴヌクレオチド(オリゴ)であって、該オリゴが、約0〜15%のアデノシ
   ン(A)を含み、かつ開始コドン、コーディング領域、5’-末端ゲノム側領域およ
   び3’-末端ゲノム側領域、5’イントロン-エキソン結合部および3’イントロン-
   エキソン結合部、および肺気道不全に関連する標的ポリペプチドをコードしてい
   る遺伝子の該結合部の2〜10ヌクレオチド内の領域からなる群から選択される、
   標的のアンチセンスであるもの、または該ポリペプチドmRNAのアンチセンスであ
   るもの；それらのオリゴの組み合わせ；またはそれらのオリゴの混合物；ならび
   に 医薬としてまたは獣医学的に許容可能な担体または希釈剤 を含む、医薬組成物。
2. 【請求項２】 オリゴがAフリーである、請求項1の組成物。
3. 【請求項３】 オリゴが、開始コドン、コーディング領域、5’-末端ゲノム
   側領域および3’-末端ゲノム側領域、5’イントロン-エキソン結合部および3’
   イントロン-エキソン結合部、および肺気道不全に関連する標的ポリペプチドを
   コードしている遺伝子、およびガン遺伝子の該結合部の2〜10ヌクレオチド内の
   領域からなる群から選択される、標的のアンチセンスであるもの、または該ポリ
   ペプチドmRNA、および該ガン遺伝子mRNAのアンチセンスであるもの；それらのオ
   リゴの組み合わせ；またはそれらのオリゴの混合物であり、 該ポリペプチドが、ペプチド性の因子および伝達物質、抗体、サイトカインお
   よびケモカイン、酵素、結合タンパク質、接着分子、それらのレセプターならび
   に悪性腫瘍関連ペプチドからなる群から選択される、請求項1の組成物。
4. 【請求項４】 オリゴが、開始コドン、コーディング領域、5’-末端ゲノム
   側領域および3’-末端ゲノム側領域、5’イントロン-エキソン結合部および3’
   イントロン-エキソン結合部、および肺気道不全に関連する標的ポリペプチドを
   コードしている遺伝子、およびガン遺伝子の該結合部の2〜10ヌクレオチド内の
   領域からなる群から選択される、標的のアンチセンスであるもの、または該ポリ
   ペプチドmRNA、および該ガン遺伝子mRNAのアンチセンスであるもの；それらのオ
   リゴの組み合わせ；またはそれらのオリゴの混合物であり、 該ポリペプチドが、転写因子、刺激化および活性化ペプチド因子、サイトカイ
   ン、サイトカインレセプター、ケモカイン、ケモカインレセプター、アデノシン
   レセプター、ブラジキニンレセプター、内因性産生特異的および非特異的酵素、
   イミノグロブリンおよび抗体、抗体レセプター、中枢神経系(CNS)および末梢神
   経系および非神経系レセプター、CNおよび末梢神経および非神経系ペプチド性伝
   達物質、接着分子、デフェンシン、成長因子、血管作動性ペプチドおよびレセプ
   ター、結合タンパク質、ならびに悪性腫瘍関連タンパク質からなる群から選択さ
   れる、請求項3の組成物。
5. 【請求項５】 コードされるポリペプチドが、アデノシンレセプターAl、A2
   a、A2bおよびA3、ブラジキニンレセプターB1およびB2、Nf6B転写因子、インター
   ロイキン-8レセプター(IL-8R)、インターロイキン−5レセプター(IL-5R)、イン
   ターロイキン4レセプター(IL-4R)、インターロイキン3レセプター(IL-3R)、イン
   ターロイキン-1β(IL-1β)、インターロイキン1βレセプター(IL-1βR)、エオタ
   キシン、トリプターゼ、主要塩基性タンパク質、β2-アドレナリン作動性レセプ
   ター、キナーゼ、エンドセリンレセプターA、エンドセリンレセプターB、プレプ
   ロエンドセリン、ブラジキニンB2レセプター、IgE高親和性レセプター、インタ
   ーロイキン1(IL-1)、インターロイキン1レセプター(IL-IR)、インターロイキン9
   (IL-9)、インターロイキン-9レセプター(IL-9R)、インターロイキン11(IL-11)、
   インターロイキン-11レセプター(IL−11R)、誘導性酸化窒素シンターゼ、シクロ
   オキシゲナーゼ-1(COX-1)、シクロオキシゲナーゼ-2(COX-2)、細胞間接着分子1(
   ICAM-1）、血管細胞性接着分子(VCAM)、ランテス、内皮性白血球接着分子(ELAM-
   1)、単球活性化因子、好中球遊走化因子、好中球エラスターゼ、デフェンシン1
   、2および3、ムスカリン様アセチルコリンレセプター、血小板活性化因子、組織
   壊死因子α、5−リポキシゲナーゼ、ホスホジエステラーゼIV、サブスタンスP、
   サブスタンスPレセプター、ヒスタミンレセプター、キマーゼ、CCR-I CCケモカ
   インレセプター、CCR-2 CCケモカインレセプター、CCR-3 CCケモカインレセプタ
   ー、CCR-4 CCケモカインレセプター、CCR-5 CCケモカインレセプター、プロスタ
   ノイドレセプターs、GATA-3転写因子、好中球接着レセプター、MAPキナーゼ、イ
   ンターロイキン-9(IL-9)、NFAT転写因子、STAT 4、MIP-Iα、MCP-2、MCP-3、MCP
   -4、シクロフィリン、ホスホリパーゼA2、塩基性繊維芽細胞成長因子、メタロプ
   ロティナーゼ、CSBP/p38 MAPキナーゼ、トリプトースレセプター、PDG2、インタ
   ーロイキン-3(IL-3)、インターロイキン-lβ(IL−1β)、シクロスポリンA結合タ
   ンパク質、FK5-結合タンパク質、α41セレクチン、フィブロネクチン、α4β7セ
   レクチン、Mad CAM-1、LFAI(CDlla/CD18)、PECAM-1、LFA-I、セレクチン、C3bi
   、PSGL-1、E-セレクチン、P-セレクチン、CD-34、L−セレクチン、p150，95，Ma
   c-1(CD11b/CD18)、フコシルトランスフェラーゼ、VLA-4、CD-18/CD11a、CD11b/C
   D18、ICAM2およびICAM3、C5a、CCR3(エオタキシンレセプター)、CCR1、CCR2、CC
   R4、CCR5、LTB-4、AP-1転写因子、プロテインキナーゼC、システイニルロイコト
   リエンレセプター、タキシンニン（Tachychinnen）レセプター(tach R)、I6Bキ
   ナーゼ1および2、STAT 6、c-masならびにNF-インターロイキン-6(NF-11-6)から
   なる群から選択される、請求項4の薬剤。
6. 【請求項６】 請求項1の組成物であって、1以上のAが、チミジン塩基へ結
   合するが、アデノシンA1、A2a、A2bおよびA3レセプターにおけるアンタゴニスト
   活性と約0．3未満のアデノシン塩基アゴニストまたはアンタゴニスト活性とを有
   するヘテロ芳香族塩基からなる群から選択されるユニバーサル塩基によって置換
   されている、請求項1の組成物。
7. 【請求項７】 ヘテロ芳香族塩基が、O、ハロ、NH₂、SH、SO、SO₂、SO₃、CO
   OHによって置換されていてもよく、分枝化されていてもよく、かつ一級および二
   級アミノ、アルキル、アルケニル、アルキニル、シクロアルキル、ヘテロシクロ
   アルキル、、アリール、ヘテロアリール、アルコキシ、アルケノキシ、アシル、
   シクロアシル、アリールアシル、アルキノキシ、シクロアルコキシ、アロイル、
   アリルチオ、アリルスルホキシル、ハロシクロアルキル、アルキルシクロアルキ
   ル、アルケニルシクロアルキル、アルキニルシクロアルキル、ハロアリール、ア
   ルキルアリール、アルケニルアリール、アルケニルアリール、アリールアルキル
   、アリールアルケニル、アリールシクロアルキルと融合していてもよく、さらに
   O、ハロ、NH₂、一級、二級および三級アミン、SH、SO、SO₂、SO₃、シクロアルキ
   ル、ヘテロシクロアルキルおよびヘテロアリールで置換されていてもよい、ピリ
   ミジンおよびプリンから選択される、請求項6の組成物。
8. 【請求項８】 ピリミジンおよびプリンが、位置1、2、3、4、7および8から
   なる群から選択される位置で置換され、かつピリミジンおよびプリンが、チオフ
   ェリン、カフェイン、ジピリン、エトフィリン、アセフィリンピペラジン、バミ
   フィリン、エンプロフィリン、以下の化学式を有するキサンチンからなる群から
   選択される、請求項7の組成物 【化１】 ［式中、R1およびR2は独立して、H、アルキル、アルケニルまたはアルキニルで
   あり、 R3は、H、アリール、ジシクロアルキル、ジシクロアルケニル、シクロアルキル
   、シクロアルケニル、シクロアルキニル、O-シクロアルキル、O-シクロアルケニ
   ル、O-シクロアルキニル、NH2-アルキルアミノ-ケトキシアルキルオキシアリー
   ル、ならびにモノおよびジアルキルアミノアルキル-N-アルキルアミノ-SO2アリ
   ールである］。
9. 【請求項９】 ユニバーサル塩基が、3-ニトロピロール-2’-デオキシヌク
   レオシド、5-ニトロ-インドール、2-ジ-オキシリボシル-(5-ニトロインドール)
   、2ジオキシリボルラノシル-(S-ニトロインドール)、2’-デオキシイノシン、2
   ’-デオキシネブラリン、6H、8H-3、4-ジヒドロピリミド[4、5-c]オキサジン-7-
   オンまたは2-アミノ-6-メトキシアミノプリンからなる群から選択されるユニバ
   ーサル塩基である、請求項8の組成物。
10. 【請求項１０】 1以上のメチル化シトシン（^mC）が、オリゴ中に存在すれ
    ば、1以上のCpGジヌクレオチド中のCについて置換されている、請求項1の組成物
    。
11. 【請求項１１】 オリゴの1以上のモノヌクレオチド残基が、1以上のメチル
    ホスホネート、ホスホトリエステル、ホスホロチオエート、ホスホロジチオエー
    ト、ボラノホスフェート、ホルムアセタール、チオホルムアセタール、チオエー
    テル、カルバネート、カルバメート、スルフェート、スルホネート、スルファメ
    ート、スルホンアミド、スルホン、スルファイト、スルホキシド、スルフィド、
    ヒドロキシアミン、2’-O-メチル、メチレン（メチルイミノ）（MMI）、メチレ
    ンオキシ（メチルイミノ）（MOM）、メトキシエチル（MOE）、メチレンオキシ（
    メチルイミノ）（MOMI）、2’-O-メチル、ホスホルアミデート、C-5置換残基、
    またはそれらの組み合わせによって、接続または改変されている、請求項1の組
    成物。
12. 【請求項１２】 モノヌクレオチド残基が、ホスホロチオエート残基によっ
    て接続されている、請求項11の組成物。
13. 【請求項１３】 アンチセンスオリゴヌクレオチドが、約7〜60モノヌクレ
    オチドからなる、請求項1の組成物。
14. 【請求項１４】 オリゴが、フラグメント1、3、5、7および8〜2313（配列
    番号1〜2419）である、請求項1の組成物。
15. 【請求項１５】 アンチセンスオリゴが、細胞内面化または取り込み薬剤、
    および細胞標的化薬剤から選択される一の薬剤へ、実施可能なように接続されて
    いるか、または複合化されている、請求項1の組成物。
16. 【請求項１６】 細胞内面化薬剤または細胞取り込み薬剤が、トランスフェ
    リン、アシアログリコタンパク質およびストレプトアビジンからなる群から選択
    される、請求項15の組成物。
17. 【請求項１７】 オリゴが原核性または真核性のベクターであるベクターに
    実施可能なように接続されている、請求項1の組成物。
18. 【請求項１８】 オリゴ（単数または複数）が、リボ核酸へハイブリダイズ
    する、請求項1の組成物。
19. 【請求項１９】 請求項1のオリゴを有する、細胞。
20. 【請求項２０】 担体または希釈剤が、気体、液体および固体の単体または
    希釈剤からなる群から選択される、請求項1の組成物。
21. 【請求項２１】 他の治療的薬剤、界面活性剤、芳香および着色剤、充填剤
    、揮発性油、緩衝化剤、分散化剤、RNA不活性化剤、抗酸化剤、芳香剤、噴射剤
    ならびに保存剤からなる群から選択される薬剤をさらに含む、請求項20の組成物
    。
22. 【請求項２２】 1以上のオリゴ、界面活性剤ならびにオリゴおよび界面活
    性剤のための担体または希釈剤を含む、請求項21の組成物。
23. 【請求項２３】 薬剤が、酵素、所望によりリボザイムを含むRNA不活性か
    薬剤である、請求項21の組成物。
24. 【請求項２４】 アンチセンスオリゴが、組成物の約0.01〜約99.99（重量
    ／重量）の量で存在する、請求項1の組成物。
25. 【請求項２５】 全身または局所製剤である、請求項1の組成物。
26. 【請求項２６】 経口、口内、肺内、直腸、子宮内、腫瘍内、頭蓋内、鼻用
    、筋肉内、皮下、血管内、鞘内、吸入型、経皮、皮内、腔内、植込用イオン泳動
    用、接眼用、膣用、関節内、眼用（otical）、静脈内、筋肉内、腺内、組織内、
    リンパ管内、植込用、徐放性および腸溶性被覆の製剤からなる群から選択される
    、請求項25の製剤。
27. 【請求項２７】 経口製剤であって、担体が、液体または固体の担体から得
    選択される、請求項26の製剤。
28. 【請求項２８】 粉末剤、糖衣丸剤、タブレット、カプセル剤、シロップ剤
    、エアゾール剤、液剤、懸濁剤ならびに所望により水中油型乳剤および油中水型
    乳剤である乳剤からなる群から選択される、請求項27の経口製剤。
29. 【請求項２９】 局所製剤であり、担体が、クリーム剤、ゲル剤、軟膏剤、
    シロップ剤、エアゾール剤、パッチ剤、液剤、懸濁剤および乳剤からなる群から
    選択される、請求項25の製剤。
30. 【請求項３０】 注射用製剤であり、担体が、水性およびアルコール性の液
    剤および懸濁剤、油性の液剤および懸濁剤ならびに水中油型および油中水型乳剤
    からなる群から選択される、請求項26の製剤。
31. 【請求項３１】 直腸用製剤、所望により坐剤である、請求項26の製剤。
32. 【請求項３２】 経皮用製剤であり、担体が、水性およびアルコール性の液
    剤、油性の液剤および懸濁剤ならびに水中油型および油中水型乳剤からなる群か
    ら選択される、請求項26の製剤。
33. 【請求項３３】 イオン泳動経費要請剤であり、担体が、水性およびアルコ
    ール性の液剤および懸濁剤、油性の液剤および懸濁剤ならびに水中油型および油
    中水型乳剤からなる群から選択され、かつ製剤が、経皮輸送促進薬剤をさらに含
    む、請求項32の経皮用製剤。
34. 【請求項３４】 インプラント、カプセルまたはカートリッジで供給される
    、請求項26の製剤。
35. 【請求項３５】 担体が、水性およびアルコール性の液剤および懸濁剤、油
    性の液剤および懸濁剤ならびに水中油型および油中水型乳剤からなる群から選択
    される、請求項20の組成物。
36. 【請求項３６】 担体が、疎水性担体を含む、請求項20の製剤。
37. 【請求項３７】 担体が、液体ビヒクル、所望によりリポゾーム、または粒
    子、所望により微結晶である、請求項36の製剤。
38. 【請求項３８】 担体がリポゾームであり、リポゾームがアンチセンスオリ
    ゴを含む、請求項37の製剤。
39. 【請求項３９】 呼吸用または吸入用製剤、所望によりエアゾール剤である
    、請求項26の製剤。
40. 【請求項４０】 単数または複数のユニット剤形である、請求項1の組成物
    。
41. 【請求項４１】 バルクである、請求項1の組成物。
42. 【請求項４２】 以下を含む、キット： 送達デバイス; セパレートコンテナー（単数または複数）中の、請求項1のオリゴ（単数また
    は複数）;ならびに 担体の添加のためのインストラクションおよびキットの使用のためのインスト
    ラクション。
43. 【請求項４３】 製剤が呼吸用製剤であり、送達デバイスが、製剤の単回計
    量された用量を送達するネブライザーを含む、請求項42のキット
44. 【請求項４４】 ネブライザーが、注入器を含み、組成物が穿孔可能なまた
    は開封可能なカプセルまたはカートリッジで供給される、請求項43のキット。
45. 【請求項４５】 送達デバイスが、加圧化吸入器を含み、かつ組成物が、オ
    リゴの懸濁物、溶解物または乾燥製剤を含む、請求項44の製剤。
46. 【請求項４６】 セパレートコンテナー中に、他の治療的薬剤、界面活性剤
    、抗酸化剤、芳香剤、充填剤、揮発性油、分散化剤、抗酸化剤、噴射剤、保存剤
    、緩衝化剤、RNA不活性化剤、細胞内面化または取り込み薬剤、および着色剤か
    らなる群から選択される薬剤をさらに含む、請求項45のキット。
47. 【請求項４７】 セパレートコンテナー中に、1以上のオリゴ、1以上の界面
    活性剤および担体または希釈剤、ならびに所望により他の治療的薬剤を含む、請
    求項46のキット。
48. 【請求項４８】 デバイスが、経皮送達デバイスであり、かつキットが、経
    皮送達薬剤、経皮担体または希釈剤、および経皮送達製剤調剤のためのインスト
    ラクションをさらに含む、請求項42のキット。
49. 【請求項４９】 デバイスが、イオン泳動送達デバイスであり、かつキット
    が、イオン泳動送達薬剤、およびイオン送達製剤調剤のためのインストラクショ
    ンをさらに含む、請求項42のキット。
50. 【請求項５０】 1以上の標的ポリヌクレオチドのアンチセンスオリゴヌク
    レオチド（単数または複数）を送達するためのインビボの方法であって、対象の
    呼吸系へ、該ポリヌクレオチドのアンチセンスであるオリゴの1以上を、該標的
    ポリヌクレオチドへ到達し、ハイブリダイズし、かつ標的mRNAの産生もしくは供
    給を減じるか、標的mRNAの分解を増大するか、または肺中に存在する標的ポリヌ
    クレオチドの量を減じるのに効果的な量で、投与することを含む、前記方法。
51. 【請求項５１】 気管支収縮および／または肺炎、アレルギー、またはサー
    ファクタント枯渇もしくは分泌不全に関連する標的ポリヌクレオチドのアンチセ
    ンスオリゴヌクレオチド（単数または複数）を送達するためのインビボの方法で
    あって、該標的ポリヌクレオチドへ到達し、ハイブリダイズし、かつ標的ポリヌ
    クレオチドの転写および／または発現を減じるか、または阻害するのに効果的な
    量の請求項1の組成物を、対象へ投与し、そしてそれにより、気管支収縮および
    ／または肺炎、アレルギー、またはサーファクタント枯渇もしくは分泌不全を緩
    和することを含む、前記方法。
52. 【請求項５２】 投与される組成物が、オリゴ（単数または複数）の一定量
    を含み、かつ哺乳類へ投与されたときに、気管支収縮および／または肺炎、アレ
    ルギー、またはサーファクタント枯渇もしくは分泌不全を緩和するのに効果的な
    条件下で投与される、請求項51の方法。
53. 【請求項５３】 組成物が対象の呼吸系へ投与される、請求項51の方法。
54. 【請求項５４】 組成物が対象の肺（単数または複数）へ投与される、請求
    項53の方法。
55. 【請求項５５】 投与される組成物が、オリゴ（単数または複数）を含み、
    かつ標的mRNAの、産生もしくは供給を減じるのに、または分解を増大するのに、
    または肺中に存在する標的ポリヌクレオチドの量を減じるのに効果的な量のオリ
    ゴを含む、請求項51の方法。
56. 【請求項５６】 薬剤が、呼吸可能なエアゾールとして投与される、請求項
    51の方法。
57. 【請求項５７】 気管支収縮および／または肺炎、アレルギー、またはサー
    ファクタント枯渇もしくは分泌不全が、肺収縮、炎症、アレルギー、喘息、切迫
    呼吸（impeded resriration）、呼吸窮迫症候群（RDS）、痛み、嚢胞性線維症、
    肺高血圧、肺血管収縮、気腫、慢性閉塞肺疾患（COPD）(chronic obstructive p
    ulmonary disease)、肺移植切除、肺感染症、気管支炎および肺ガンからなる群
    から選択される疾患または状態に関連する、請求項51の方法。
58. 【請求項５８】 疾患または状態が、アレルギーに関連し、かつオリゴが、
    開始コドン、コーディング領域、5’-末端ゲノム側領域および3’-末端ゲノム側
    領域、5’イントロン-エキソン結合部および3’イントロン-エキソン結合部、お
    よびイミノグロブリン（単数または複数）および抗体（単数または複数）ならび
    にイミノグロブリンレセプターおよび抗体レセプターをコードしている遺伝子の
    該結合部の2〜10ヌクレオチド内の領域からなる群から選択される、標的のアン
    チセンスであるもの、またはイミノグロブリンおよび抗体ならびにイミノグロブ
    リンレセプターおよび抗体レセプターの、mRNAのアンチセンスであるもの；それ
    らのオリゴの組み合わせ；またはそれらのオリゴの混合物である、請求項57の方
    法。
59. 【請求項５９】 疾患または状態が、悪性腫瘍またはガンに関連し、かつオ
    リゴが、開始コドン、コーディング領域、5’-末端ゲノム側領域および3’-末端
    ゲノム側領域、5’イントロン-エキソン結合部および3’イントロン-エキソン結
    合部、およびガン遺伝子または悪性腫瘍関連タンパク質をコードしている遺伝子
    の該結合部の2〜10ヌクレオチド内の領域からなる群から選択される、標的のア
    ンチセンスであるもの、またはガン遺伝子または悪性腫瘍関連タンパク質の、mR
    NAのアンチセンスであるもの；それらのオリゴの組み合わせ；またはそれらのオ
    リゴの混合物であり、該オリゴが、該mRNAまたは悪性腫瘍関連タンパク質のいず
    れかのレベルを減じるか、または悪性腫瘍細胞の増殖もしくは悪性腫瘍細胞への
    有益な物質の供給を減じるのに効果的な量で投与される、請求項57の方法。
60. 【請求項６０】 組成物が、経皮的にまたは前進的に投与される、請求項51
    の方法。
61. 【請求項６１】 組成物が、経口的に、口内的に、肺内的に、直腸的に、子
    宮内的に、腫瘍内的に、頭蓋内的に、鼻用的に、筋肉内的に、皮下的に、血管内
    的に、鞘内的に、皮内的に、腔内的に、植込用イオン泳動用的に、接眼用的に、
    膣用的に、関節内的に、静脈内的に、筋肉内的に、腺内的に、組織内的に、リン
    パ管内的に、植込により、吸引により、経皮的に、肺内的に、眼内用として（in
    traotically）、徐放によって、持続放出によって、またはポンプによって投与
    される、請求項60の方法。
62. 【請求項６２】 対象が、非ヒト哺乳類である、請求項51の方法。
63. 【請求項６３】 哺乳類が、ヒトである、請求項51の方法。
64. 【請求項６４】 オリゴが、約0.005〜約150 mg/kg体重の量で投与される、
    請求項51の方法。
65. 【請求項６５】 オリゴが、以下により得られた、請求項51の方法： (a)GおよびCからなる群から選択される少なくとも4つの近接した核酸を雨雨する
    標的核酸のフラグメントを選択すること； (b)選択されたフラグメントを含み、かつCおよびG含量が約15%以下である、4〜6
    0ヌクレオチド長の第一のオリゴヌクレオチドを得ること； および (c)選択されたフラグメントに対してアンチセンスである配列を含み、かつA塩基
    含量が約15%以下である、4〜60ヌクレオチド長の第二のオリゴヌクレオチドを得
    ること。 【請求項６５】 オリゴがA-フリーである、請求項64の方法。
66. 【請求項６６】 オリゴが、開始コドン、コーディング領域、5’-末端ゲノ
    ム側領域および3’-末端ゲノム側領域、5’イントロン-エキソン結合部および3
    ’イントロン-エキソン結合部、および肺気道不全に関連する標的ポリペプチド
    をコードしている遺伝子、およびガン遺伝子の該結合部の2〜10ヌクレオチド内
    の領域からなる群から選択される、標的のアンチセンスであるもの、または該ポ
    リペプチドmRNA、および該ガン遺伝子mRNAのアンチセンスであるもの；それらの
    オリゴの組み合わせ；またはそれらのオリゴの混合物であり、 該ポリペプチドが、転写因子、刺激化および活性化ペプチド因子、サイトカイ
    ン、サイトカインレセプター、ケモカイン、ケモカインレセプター、アデノシン
    レセプター、ブラジキニンレセプター、内因性産生特異的および非特異的酵素、
    イミノグロブリンおよび抗体、抗体レセプター、中枢神経系(CNS)および末梢神
    経系および非神経系レセプター、CNおよび末梢神経および非神経系ペプチド性伝
    達物質、接着分子、デフェンシン、成長因子、血管作動性ペプチドおよびレセプ
    ター、結合タンパク質、ならびに悪性腫瘍関連タンパク質からなる群から選択さ
    れる、請求項51の方法。
67. 【請求項６７】 オリゴ中の1以上のAが、チミジン塩基へ結合するが、アデ
    ノシンA1、A2a、A2bおよびA3レセプターにおけるアンタゴニスト活性と約0．3未
    満のアデノシン塩基アゴニストまたはアンタゴニスト活性とを有するヘテロ芳香
    族塩基からなる群から選択されるユニバーサル塩基によって置換されている、請
    求項51の方法。
68. 【請求項６８】 ヘテロ芳香族塩基が、O、ハロ、NH₂、SH、SO、SO₂、SO₃、
    COOHによって置換されていてもよく、分枝化されていてもよく、かつ一級および
    二級アミノ、アルキル、アルケニル、アルキニル、シクロアルキル、ヘテロシク
    ロアルキル、、アリール、ヘテロアリール、アルコキシ、アルケノキシ、アシル
    、シクロアシル、アリールアシル、アルキノキシ、シクロアルコキシ、アロイル
    、アリルチオ、アリルスルホキシル、ハロシクロアルキル、アルキルシクロアル
    キル、アルケニルシクロアルキル、アルキニルシクロアルキル、ハロアリール、
    アルキルアリール、アルケニルアリール、アルケニルアリール、アリールアルキ
    ル、アリールアルケニル、アリールシクロアルキルと融合していてもよく、さら
    にO、ハロ、NH₂、一級、二級および三級アミン、SH、SO、SO₂、SO₃、シクロアル
    キル、ヘテロシクロアルキルおよびヘテロアリールで置換されていてもよい、ピ
    リミジンおよびプリンから選択される、請求項67の方法。
69. 【請求項６９】 ピリミジンおよびプリンが、位置1、2、3、4、7および8か
    らなる群から選択される位置で置換され、かつピリミジンおよびプリンが、チオ
    フェリン、カフェイン、ジピリン、エトフィリン、アセフィリンピペラジン、バ
    ミフィリン、エンプロフィリン、以下の化学式を有するキサンチンからなる群か
    ら選択される、請求項67の方法 【化２】 ［式中、R1およびR2は独立して、H、アルキル、アルケニルまたはアルキニルで
    あり、 R3は、H、アリール、ジシクロアルキル、ジシクロアルケニル、シクロアルキル
    、シクロアルケニル、シクロアルキニル、O-シクロアルキル、O-シクロアルケニ
    ル、O-シクロアルキニル、NH2-アルキルアミノ-ケトキシアルキルオキシアリー
    ル、ならびにモノおよびジアルキルアミノアルキル-N-アルキルアミノ-SO2アリ
    ールである］。
70. 【請求項７０】 ユニバーサル塩基が、3-ニトロピロール-2’-デオキシヌ
    クレオシド、5-ニトロ-インドール、2-ジ-オキシリボシル-(5-ニトロインドール
    )、2ジオキシリボルラノシル-(S-ニトロインドール)、2’-デオキシイノシン、2
    ’-デオキシネブラリン、6H、8H-3、4-ジヒドロピリミド[4、5-c]オキサジン-7-
    オンまたは2-アミノ-6-メトキシアミノプリンからなる群から選択されるユニバ
    ーサル塩基である、請求項69の方法。
71. 【請求項７１】 1以上のメチル化シトシン（^mC）が、オリゴ中に存在すれ
    ば、1以上のCpGジヌクレオチド中のCについて置換されている、請求項51の方法
    。
72. 【請求項７２】 オリゴの1以上のモノヌクレオチド残基が、1以上のメチル
    ホスホネート、ホスホトリエステル、ホスホロチオエート、ホスホロジチオエー
    ト、ボラノホスフェート、ホルムアセタール、チオホルムアセタール、チオエー
    テル、カルバネート、カルバメート、スルフェート、スルホネート、スルファメ
    ート、スルホンアミド、スルホン、スルファイト、スルホキシド、スルフィド、
    ヒドロキシアミン、2’-O-メチル、メチレン（メチルイミノ）（MMI）、メチレ
    ンオキシ（メチルイミノ）（MOM）、メトキシエチル（MOE）、メチレンオキシ（
    メチルイミノ）（MOMI）、2’-O-メチル、ホスホルアミデート、C-5置換残基、
    またはそれらの組み合わせによって、さらに置換または改変されている、請求項
    51の方法。
73. 【請求項７３】 オリゴが、細胞内面化または取り込み薬剤、および細胞標
    的化薬剤から選択される一の薬剤へ、実施可能なように接続されているか、また
    は複合化されている、請求項1の組成物。.
74. 【請求項７４】 細胞内面化薬剤または細胞取り込み薬剤が、トランスフェ
    リン、アシアログリコタンパク質およびストレプトアビジンからなる群から選択
    される、請求項73の方法。
75. 【請求項７５】 細胞標的化薬剤が、ベクター、所望により原核性または真
    核性のベクターである、請求項73の方法。
76. 【請求項７６】 請求項56の方法を実施することを含む、肺気道に関連する
    疾患または状態の治療方法。
77. 【請求項７７】 投与されるオリゴの量が、標的mRNAの、産生もしくは供給
    を減じるのに、または分解を増大するのに、または肺中に存在する標的ポリヌク
    レオチドの量を減じるのに効果的な量である、請求項76の方法。
78. 【請求項７８】 投与されるオリゴの量が、標的mRNAの、産生もしくは供給
    を減じるのに、または分解を増大するのに、または患者の肺中に存在する標的ポ
    リヌクレオチドの量を減じるのに効果的な量である、請求項77の方法。
79. 【請求項７９】 該オリゴが、約0〜15%のアデノシン(A)を含み、かつ開始
    コドン、コーディング領域、5’-末端ゲノム側領域および3’-末端ゲノム側領域
    、5’イントロン-エキソン結合部および3’イントロン-エキソン結合部、および
    アデノシンA1、A2a、A2bおよびA3レセプターに関連する標的ポリペプチドをコー
    ドしている遺伝子の該結合部の2〜10ヌクレオチド内の領域からなる群から選択
    される、標的のアンチセンスであるもの、またはアデノシンA1、A2a、A2bおよび
    A3レセプターmRNAのアンチセンスであるものである、請求項1の組成物。
80. 【請求項８０】 ヌクレオチドを接続しているすべての残基が、ホスホロチ
    オエートである、請求項79の組成物。
81. 【請求項８１】 オリゴが、DNAである、請求項1の組成物。
82. 【請求項８２】 オリゴが、RNAである、請求項1の組成物。
83. 【請求項８３】 オリゴが、約7〜60モノヌクレオチドを含むオリゴである
    、請求項1の組成物。
84. 【請求項８４】 オリゴが、配列番号1、3、5、7、8および／または11〜231
    3のフラグメントからなる群から選択され、所望により1以上のモノヌクレオチド
    残基が、1以上のメチルホスホネート、ホスホトリエステル、ホスホロチオエー
    ト、ホスホロジチオエート、ボラノホスフェート、ホルムアセタール、チオホル
    ムアセタール、チオエーテル、カルバネート、カルバメート、スルフェート、ス
    ルホネート、スルファメート、スルホンアミド、スルホン、スルファイト、スル
    ホキシド、スルフィド、ヒドロキシアミン、2’-O-メチル、メチレン（メチルイ
    ミノ）（MMI）、メチレンオキシ（メチルイミノ）（MOM）、メトキシエチル（MO
    E）、メチレンオキシ（メチルイミノ）（MOMI）、2’-O-メチル、ホスホルアミ
    デート、C-5置換残基、またはそれらの組み合わせによって、接続または改変さ
    れている、請求項79の組成物。
85. 【請求項８５】 オリゴが、対象の気管支、呼吸器または肺の上皮へ局所的
    に投与される、請求項51の方法。
86. 【請求項８６】 オリゴが、約5〜10μmの、または約10〜500μmの範囲の粒
    子サイズを有する、請求項1の組成物。
87. 【請求項８７】 オリゴへ添加される噴射剤をさらに含む、請求項1の組成
    物。
88. 【請求項８８】 オリゴが、約5〜10μmの、または約10〜500μmの範囲の粒
    子サイズを有する、請求項50の方法。
89. 【請求項８９】 オリゴへ添加される噴射剤をさらに含む、請求項50の方法
    。
90. 【請求項９０】 オリゴが、約5〜10μmの、または約10〜500μmの範囲の粒
    子サイズを有する、請求項51の方法。
91. 【請求項９１】 オリゴへ添加される噴射剤をさらに含む、請求項51の方法
    。