CN1298730A - Process for preparing 'Qianjin' capsule to treat genopathy - Google Patents

Abstract

A qianjin capsule for treating gynaecopathia is made of euphorbiae lathyridis, radix rosea laevigatae, herba andrographitis, radix angelicae sinensis, caulis mahoniae, caulis spatholobi, and radix codonopsis pilosulae as raw materials, and its processing technology is as follows: use ethyl alcohol to extract radix angelicae sinensis and herba andrographitis to obtain clear paste; decoct euphorbiae lathyridis, radix rosea laevigatea etc to obtain decoction liquid, decoct and filter twice to obtain filtrate, combined and make into clear paste, and finally combine all pastes, mix uniformly and spray dried, then pelletize and fill to obtain capsule.

Description

A kind of processing technology of FUKE QIANJIN JIAONANG

The present invention relates to a kind of processing technology of FUKE QIANJIN JIAONANG, belong to the manufacturing process class of Chinese medicinal capsule preparation.

China's Chinese medicine generally adopts decoction, pill, powder etc., later on along with tablet has appearred again in society's science and technology, economic progress.FUKE QIANJIN PIAN is to be raw material with very heavy group of Chinese crude drug, Radix Rosae Laevigatae, Herba Andrographis, Radix Angelicae Sinensis, Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Caulis Spatholobi and Radix Codonopsis, through the tablet form compound Chinese patent medicine of selecting materials, pulverizing, operation such as granulation, Bao Qian being made.Clinical practice through has for many years shown that it is a kind of a kind of good medicine that is applicable to gynaecopathias such as woman uterus inflammation, urgent chronic pelvic inflammatory disease, endometritis, menoxenia, leucorrhoea grow in quantity really.

The Chinese patent medicine FUKE QIANJIN PIAN is a kind of rare gynecological's good medicine, but it still exists some weakness of Chinese patent medicine tablet: dose is bigger, will eat 6 at every turn; Patient is when taking this tablet, though eaten into the effective ingredient that it works the effect of curing the disease, the adjuvant of in fact also having eaten into fiber such as quite a few plant roots that contains these medicine active ingredients, stem, leaf and invalid element simultaneously and having added in production process.And patient is after taking medicine, and some effective ingredient can not fully be digested and assimilated and excrete thereupon by the intestines and stomach; Patient is after taking medicine, and tablet disintegration time under one's belt is long, it is slow or the like to take effect.So how to improve the bioavailability of Chinese medicine, active ingredient is fully extracted, improving curative effect of medication is the developing direction of Chinese patent medicine, capsule then is one of its correct selection path.

Purpose of the present invention aims to provide the requirement of a kind of adaptation FUKE QIANJIN PIAN compatibility, can make the FUKE QIANJIN JIAONANG production technology of its performance optimum curative effect.

This is the FUKE QIANJIN JIAONANG of compatibility by very heavy group of Chinese crude drug, Radix Rosae Laevigatae, Herba Andrographis, Radix Angelicae Sinensis, Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Caulis Spatholobi and Radix Codonopsis, and its processing technology is:

A, at first Radix Angelicae Sinensis is extracted with alcohol percolation method make clear paste;

B, Herba Andrographis extracted with ethanol refluxing process make clear paste;

C, Caulis Mahoniae, Fructus Zanthoxyli Dissiti decocting in water are extracted twice, after filtering the merging of both filtrates is made clear paste;

D, very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis decocting in water are extracted an after-filtration, the medicinal residues after the filter with the Radix Angelicae Sinensis medicinal residues of technology A and the Herba Andrographis medicinal residues decocting in water of technology B, are filtered, merging filtrate is also made clear paste;

E, merge above-mentioned A, B, four kinds of clear paste of C, D, through mixing-spray drying-granulation-fill four procedures the finished product FUKE QIANJIN JIAONANG.

According to the FUKE QIANJIN JIAONANG that above-mentioned process program is produced, to compare with the FUKE QIANJIN PIAN that has circulated at present the city, its advantage is to make the active ingredient extraction in the medical material more abundant, the relative enrichment of active ingredient; Simultaneously medicine disintegration time under one's belt shortens, and has eliminated former mixing and has contained the invalid thing in the Herba Andrographis and Radix Angelicae Sinensis in the FUKE QIANJIN PIAN, and patient's drug administration amount is reduced, and improves the curative effect instant effect.

Below provide embodiment, and further set forth the present invention in conjunction with the embodiments.

Prescription according to the compound women's QIANJIN PIAN: the incorporation of Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis and Fructus Zanthoxyli Dissiti respectively is 9% of a medical material total amount; The incorporation of Radix Rosae Laevigatae, Caulis Spatholobi, Caulis Mahoniae and Radix Flemingiae Philippinensis respectively is 16% of medical material portion amount.Then, at first Radix Angelicae Sinensis is extracted with alcohol percolation method and make clear paste according to above-mentioned process; Secondly Herba Andrographis is extracted with ethanol refluxing process and make clear paste; It three is that Caulis Mahoniae, Fructus Zanthoxyli Dissiti decocting in water are extracted twice, after filtering twice filtrate merging is made clear paste; It four is with very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, after-filtration of Radix Codonopsis decocting in water, and the medicinal residues after the filter with the Radix Angelicae Sinensis medicinal residues of technology A and the Herba Andrographis medicinal residues decocting in water of technology B, are filtered and merge two filtrates and also make clear paste; Its five be merge above-mentioned four kinds of clear paste, through mixing-spray drying-granulation-fill four procedures FUKE QIANJIN JIAONANG.

In above-mentioned operation, what really play effect is that above-mentioned all medical materials are adopted the method for extracting of handling respectively; Experiment through this programme inventor: adopt the difference decocting in water extracting method of Radix Rosae Laevigatae, very heavy group and Caulis Mahoniae and Fructus Zanthoxyli Dissiti, than decocting in water extraction that above-mentioned four kinds of medical materials are mixed, the content of tannin and berberine exceeds 2.5～5 times respectively in its filtrate.

Zoopery is the result show: FUKE QIANJIN JIAONANG all has the obvious suppression effect to rat paw edema due to Oleum Tiglii induced mice ear swelling, the chondrus ocellatus Holmes and rat cotton balls granuloma.The scorching card of rat uterus also there is good inhibitory action, and the effect of capsule sheet is better than the tablet FUKE QIANJIN JIAONANG can resist the capillary permeability increase effect of acetic acid induced mice abdominal cavity, to the tangible blood tonification effect of type blood deficiency mice tool of losing blood, can also resist the immune function of mice reduction that cyclophosphamide causes.Extracorporeal bacteria inhibitor test is the result show: to 9 kinds of antibacterials such as escherichia coli the clinical separation of totally 95 strains cause bacterium certain bacteriostasis arranged.To the coli-infection mice, high dose has the certain protection effect, and the capsule effect slightly is better than tablet.

The clinical application observe the curative effect is as follows:

Through No. 1 Hospital Affiliated to Hunan Traditional Chinese Medical College, Hunan Province woman keep healthy institute, Hunan Province Affiliated Hospital of the academy of traditional Chinese medicine from March, 1998～1998 year November to 381 routine women's chronic pelvic inflammatory diseases, chronic endometritis, chronic cervicitis patient, adopt FUKE QIANJIN PIAN, FUKE QIANJIN JIAONANG, three kinds of medicines of JINJI PIAN to treat, test group (FUKE QIANJIN JIAONANG group) 161 examples wherein, matched group (FUKE QIANJIN PIAN group) 100 examples; Chronic palace intimitis 60 examples, wherein each 30 example of test group (FUKE QIANJIN JIAONANG group) and matched group (FUKE QIANJIN PIAN group); Chronic cervicitis 60 examples, wherein each 30 example of test group (FUKE QIANJIN JIAONANG group) and matched group (FUKE QIANJIN PIAN group).And with state of an illness integrated value judgement curative effect before and after the treatment.

The result shows: the total obvious effective rate of (1) FUKE QIANJIN JIAONANG treatment chronic pelvic inflammatory disease, total effective rate are respectively 80.12%, 98.75%; Treat the total obvious effective rate of chronic palace intimitis, total effective rate is respectively 100%, 100%; The total obvious effective rate of treatment chronic cervicitis, total effective rate are respectively 33.3%, 96.7%; Its determined curative effect is better than FUKE QIANJIN PIAN sheet group; The medicine of (2) two kinds of dosage forms all has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, benefiting qi and nourishing blood, strong waist and nourishing kidney, chronic pelvic inflammatory disease, chronic palace intimitis, chronic cervicitis patient all there is better curative effect, (3) FUKE QIANJIN JIAONANG is lacked than the QIANJIN PIAN consumption, it is more convenient to take medicine, and welcome by patient and clinician; (4) FUKE QIANJIN JIAONANG drug safety is not seen toxic and side effects and untoward reaction in the observation process.

Clinical application shows: FUKE QIANJIN PIAN and FUKE QIANJIN JIAONANG curative effect obviously are better than JINJI PIAN, and the FUKE QIANJIN JIAONANG curative effect is better than FUKE QIANJIN PIAN: really reach final goal of the present invention.

Claims (1)

1, a kind of is the FUKE QIANJIN JIAONANG of compatibility by very heavy group of Chinese crude drug, Radix Rosae Laevigatae, Herba Andrographis, Radix Angelicae Sinensis, Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Caulis Spatholobi and Radix Codonopsis, and its processing technology is:

A, at first Radix Angelicae Sinensis is extracted with alcohol percolation method make clear paste;

B, Herba Andrographis extracted with ethanol refluxing process make clear paste;

C, Caulis Mahoniae, Fructus Zanthoxyli Dissiti decocting in water are extracted twice, after filtering the merging of both filtrates is made clear paste;

D, very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis decocting in water are extracted an after-filtration, the medicinal residues after filtering with the Radix Angelicae Sinensis medicinal residues of technology A and the Herba Andrographis medicinal residues decocting in water of technology B, are filtered, merging filtrate is also made clear paste;

E, merge above-mentioned A, B, four kinds of clear paste of C, D, through mixing-spray drying-granulation-fill four procedures the finished product FUKE QIANJIN JIAONANG.