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CN102274353B - Traditional Chinese preparation for treating ulcers - Google Patents

Traditional Chinese preparation for treating ulcers Download PDF

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CN102274353B
CN102274353B CN201010198216A CN201010198216A CN102274353B CN 102274353 B CN102274353 B CN 102274353B CN 201010198216 A CN201010198216 A CN 201010198216A CN 201010198216 A CN201010198216 A CN 201010198216A CN 102274353 B CN102274353 B CN 102274353B
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ulcer
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medicament
traditional chinese
inner mongol
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CN102274353A (en
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刘国钧
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Abstract

The invention discloses a traditional Chinese preparation for treating ulcers, and the traditional Chinese preparation is prepared by the following medicinal materials by weight ratio: 10-30g of Chinese gall, 8-20g of Chinese violet, 10-18g of Mongolian dandelion herb, 10-20g of figwort root, 8-15g of golden thread, 10-30g of baical skullcap root, 10-25g of vietnamese sophora root, 20-30g of natural indigo and 6-12g of borneol. The medicament is mainly used for treating oral ulcers, peptic ulcers, ulcerative colitis and other mucosal ulcer diseases, and can rapidly stop pain and astringe the ulcer surfaces, the treatment course is short, the individual differences are avoided and the treatment effects are significant. The medicament is simple in ingredients, belongs to pure traditional Chinese medicine preparations and has no toxic or side effects. The medicament powder can be effectively adsorbed on the ulcer surfaces for directly acting on focuses, the medicament effect is sustained, the adsorption of the medicament on the ulcer surfaces has not been reported in the aspect of traditional Chinese medicine theory, and the formula still belongs to the first time.

Description

The Chinese medicine preparation of treatment ulcer
Technical field:
Patent of the present invention relates to the field of Chinese medicines, relates in particular to a kind of sick Chinese medicine preparation such as oral ulcer, peptic ulcer and ulcerative colitis of treating.
Background technology:
Oral ulcer, gastric ulcer, duodenal ulcer and ulcerative colitis etc. are common ulcer.The Chinese medicine external pulvis curative effect individual variation that is used to treat oral ulcer in the market is very big; Side effect is arranged, and can not cause drug effect not continue effectively attached to the ulcer surface; Therapeutic effect is not obvious, and the medicine active adsorption did not also occur in tcm theory to the ulcer surface; Problems such as the medicine of diseases such as treatment gastric ulcer, duodenal ulcer and ulcerative colitis is a lot of, but all exists the course of treatment long, and side effect is big, and drug dose is big, and cure rate is low.
Summary of the invention
In order to overcome the above problems, the invention provides a kind of Chinese medicine preparation of treating ulcer, can effectively treat ulcers such as oral ulcer, peptic ulcer and ulcerative colitis, clearing away heat to alleviate pain is restrained ulcer surface rapidly, and ulcer is healed rapidly.
The Chinese medicine preparation prescription of treatment ulcer provided by the invention carries out a large amount of clinical experiences through the inventor to be groped to sum up out, and each amounts of components is that the following weight parts scope all has better curative effect: Galla Chinensis 10-30g, Herba Violae 8-20g, Herba Taraxaci 10-18g, Radix Scrophulariae 10-20g, Rhizoma Coptidis 8-15g, Radix Scutellariae 10-30g, Radix Sophorae Tonkinensis 10-25g, Indigo Naturalis 20-30g and Borneolum Syntheticum 6-12g.
Optimization formula is: Galla Chinensis 18g, Herba Violae 14g, Herba Taraxaci 14g, Radix Scrophulariae 15g, Rhizoma Coptidis 12g, Radix Scutellariae 24g, Radix Sophorae Tonkinensis 18g, Indigo Naturalis 24g and Borneolum Syntheticum 8g.
Drug regimen described in the present invention in the prescription makes each efficacy of drugs produce synergism, thereby drug effect is strengthened.Wherein select for use Galla Chinensis to be because Galla Chinensis is restrained, removing dampness is held back the skin ulcer hemostasis.The Herba Violae heat-clearing and toxic substances removing is used for the skin infection anti-microbial effect that swollen and ache.The Herba Taraxaci clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.The Radix Scrophulariae heat clearing away, YIN nourishing can be used for the swollen skin infection of pain.Rhizoma Coptidis nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication has anti-microbial effect.The Radix Scutellariae heat clearing away, dampness, detoxifcation has anti-microbial effect.The Radix Sophorae Tonkinensis heat-clearing and toxic substances removing, the swollen pain relieving of loosing can be used for the sore that swells and ache.The Indigo Naturalis heat-clearing and toxic substances removing, cooling blood for hemostasis can be used for pyretic toxicity pain skin ulcer.Borneol heat pain, Qu rot myogenic.
Galla Chinensis has another name called hundred worm storehouses, Mass Galla chinesis et camelliae Fermentata, gall in the raw material in the prescription according to the invention; For the Chinese Nut-gall aphid of Homoptera aphid section or the female worm of melaphis peitan Tsai et Tang parasitize Anacardiaceae plant " Fructus rhois chinensis " and belong to the tender leaf or the petiole of other plant together; Stab and generate a kind of cryptomere consor thing insect gall, gained after baking is doubly dry; Herba Violae is Violaceae Chinese violet, Herba Violae japonicae, the whole herb with root of leguminous plant Gueldenstaedtia verna, little Gueldenstaedtia verna or gentianaceae plant south China Radix Gentianae; Herba Taraxaci is named Herba crotalariae albidae again, is the dry herb of Compositae herbaceos perennial; Radix Scrophulariae is the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensis Hemsl.; Rhizoma Coptidis is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall.; Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi; Radix Sophorae Tonkinensis is the dry root and rhizome of dicotyledon medicine leguminous plant Sophora tonkinensis Gagnep.; Indigo Naturalis is claimed indigo flower, blue or green cylinder flower, the blue flower that reveals, forms sediment, indigo foam flower etc. again, be Folium Isatidis etc. through immersion, pickled, add the foam dry powder waterborne after the operation such as an amount of Calx; Borneolum Syntheticum is the processed goods of Dipterocarpaceae plant Borneolum Syntheticum.
The Chinese medicine preparation that the present invention treats ulcer can be prepared into powder and two kinds of dosage forms of capsule.
The method for preparing of medicine of the present invention is:
A) raw material is carried out the strictness screening, purify, dry, take by weighing Galla Chinensis, Herba Violae, Herba Taraxaci, Radix Scrophulariae, Rhizoma Coptidis, Radix Scutellariae and the Radix Sophorae Tonkinensis of certain weight ratio, subsequent use;
B) Galla Chinensis, Herba Violae, Herba Taraxaci, Radix Scrophulariae, Rhizoma Coptidis, Radix Scutellariae and the Radix Sophorae Tonkinensis 7 flavor medicines of said weight proportion are inserted in the heater, constantly stir, fry 30 minutes to surperficial yellow, take out subsequent use with slow fire;
C) pulverize with the medical material of electric mill after, be filtered into 800 purpose smalls with square-bottomed bamboo basket with above-mentioned parch;
D) in said smalls, add ground Indigo Naturalis and the Borneolum Syntheticum of certain weight ratio, fully be mixed into drug powder;
E) with said drug powder under aseptic condition, bottle the sealing subsequent use, both KUIYANG SAN powder; Said drug powder is pressed the conventional method for preparing of Chinese medicinal capsule agent under aseptic condition, incapsulate, promptly get Kuiyangsan Capsules, every capsules contains former medicine 0.3g.
The Chinese medicine preparation of treatment ulcer of the present invention has clearing away heat-fire, antiphlogistic antibacterial, removing heat from blood and holds back functions such as skin ulcer, and pain relieving and convergence ulcer surface make ulcer healing rapidly; Ingredient is simple, belongs to pure Chinese medicinal preparation, has no side effect; Short treating period, cure rate is high, and therapeutic effect is remarkable.But drug powder active adsorption of the present invention is surperficial in ulcer, and in the normal mucosa noresidue, directly acts on focus, and drug effect continues.Medicine is adsorbed onto the ulcer surface and on tcm theory, did not also occur, and prescription of the present invention still belongs to the first time.
Below come further to set forth the beneficial effect of medicine of the present invention through clinical observation.
Medicine of the present invention is to the clinical observation on the therapeutic effect of oral ulcer.
Physical data:
Accept out-patient's totally 23 examples for medical treatment, wherein male 11 examples, women 12 examples.Conditions of patients oral ulcer 17 examples, all rotten to the corn 2 examples of tongue, laryngopharynx swelling and pain 2 examples, gingival swelling and pain 2 examples.
Therapeutic Method:
This prescription was processed the KUIYANG SAN spray, during use, whenever sprayed once spray in day 3-6 time in the affected part at a distance from 4-6 hour.
The treatment standard:
Symptom pain degrees such as various oral ulcer, the erosion of tongue week, laryngopharynx swelling and pain and gingival swelling and pain obviously alleviate, the ulcer decreased number, and diameter reduces, and therapeutic effect does not have individual variation, and treatment cycle is short, and drug effect is remarkable.
Therapeutic outcome (seeing table 1):
Table 1 is observation of curative effect after treatment
The native place Name Sex Age The state of an illness Therapeutic Method Therapeutic outcome
The Inner Mongol Hou Hui The woman 28 Tongue week is rotten to the corn Every day 2 times Cured the same day
The Inner Mongol Chang Quankui The man 26 Oral ulcer Every day 4-6 time Cured in 2nd
The Inner Mongol Liu Shuhong The woman 30 Oral ulcer Every day 4-6 time Cured in 2nd
The Inner Mongol Yuan Yanqing The woman 30 Oral ulcer Every day 4-6 time Cured in 3rd
The Inner Mongol Li Zongze The man 5 Oral ulcer Every day 4-6 time Cured in 3rd
The Inner Mongol Guo Junpeng The man 35 Oral ulcer Every day 4-6 time Cured in 2nd
The Inner Mongol Zhang Mingyue The woman 16 Laryngopharynx swelling and pain Every day 4-6 time Cured in 3rd
The Inner Mongol Zhang Mingyue The woman 16 Gingival swelling and pain Every day 4-6 time Cured in 3rd
The Inner Mongol Zhang Haijing The woman 12 Oral ulcer Every day 4-6 time Cured in 2nd
The Inner Mongol Zhao Xianglian The woman 52 Oral ulcer Every day 4-6 time Cured in 3rd
The Inner Mongol Zhang Yangyang The man 3 Tongue week is rotten to the corn Every day 3 times Cured the same day
The Inner Mongol Bai Xumin The man 27 Oral ulcer Every day 4-6 time Cured in 3rd
The Inner Mongol Hou Shiyong The man 56 Oral ulcer Every day 4-6 time Cured in 4th
The Inner Mongol Wang Na The woman 21 Oral ulcer Every day 4-6 time Cured in 3rd
The Inner Mongol Guo Xicheng The man 59 Oral ulcer Every day 4-6 time Cured in 6th
The Inner Mongol Wang Dianyun The woman 32 Oral ulcer Every day 4-6 time Cured in 3rd
The Inner Mongol Qin Haiyan The woman 31 Gingival swelling and pain Every day 4-6 time Cured in 4th
The Inner Mongol Zhang Wei The man 24 Oral ulcer Every day 4-6 time Cured in 2nd
Shaanxi Liu Wei The man 28 Oral ulcer Every day 4-6 time Cured in 3rd
The Inner Mongol Yang Hui The woman 34 Laryngopharynx swelling and pain Every day 4-6 time Cured in 3rd
The Inner Mongol Luo Li The woman 28 Oral ulcer Every day 4-6 time Cured in 2nd
The Inner Mongol He Jian The man 30 Oral ulcer Every day 4-6 time Cured in 3rd
Through clinical observation, when medicine for ulcer powder of the present invention used, medicine was sprayed directly on to the affected part; Naked eyes are visible, and medicine can effectively be adsorbed on the ulcer surface, directly acts on focus; And in the normal oral mucosa noresidue; When the patient drank water, has a meal and gargles, ulcer surface still had drug residue, caused drug effect to continue; When this medicine is not sprayed directly on to the oral ulcer surface, but it directly is contained in the oral cavity, stirs with saliva; Through repetition test, when medicine moves to ulcer surface, still can be adsorbed onto on the oral ulcer surface; Thereby drug effect is continued, and medicine does not have this specially good effect on the market.When the patient made medicament for the first time, adsorbance was big in the affected part for medicine, and along with the ulcer surface healing, affected part absorption medicated powder amount reduces.Medicine is adsorbed onto the ulcer surface and on tcm theory, did not also occur, and prescription of the present invention still belongs to the first time.
Medicine of the present invention shows through clinical use: medicine for ulcer powder of the present invention can effectively be treated oral ulcer, the erosion of tongue week, laryngopharynx swelling and pain and gingival swelling and pain etc., and drug effect is fast, pain relieving and convergence ulcer surface rapidly, and therapeutic effect is remarkable, does not see invalid case.The drug powder active adsorption is on the ulcer surface, and the normal oral mucosa noresidue, medicine directly acts on focus, and drug effect continues significantly.Can heal in general patient affected part in 2-3 days, severe patient 5-6 day heals.
Medicine of the present invention is to the clinical observation on the therapeutic effect of peptic ulcer.
Physical data:
Accept out-patient's totally 19 examples for medical treatment, wherein male 11 examples, women 8 examples.Conditions of patients gastric ulcer 13 examples, duodenal ulcer 6 examples.
Therapeutic Method:
This prescription is processed the medicine for ulcer capsule, and every contains former medicine 0.3g, 3 times on the oral one, one time 3.
The treatment standard:
Patient's pain degree alleviates, transference cure, and gastroscopic observation, the ulcer decreased number, area reduces, and therapeutic effect is remarkable.
Therapeutic outcome (seeing table 2):
Table 2 is observation of curative effect after treatment
Figure GSB00000879962000041
Figure GSB00000879962000051
Figure GSB00000879962000061
Through clinical observation, when medicine of the present invention is processed capsule treatment peptic ulcer, pain relieving rapidly, patient affected part pain degree obviously alleviates, transference cure, through gastroscopic observation, ulcer decreased number, ulcer surface healing.The patient has minimal irritation property pain or discomfort in the affected part when medication for the first time, belong to normal drug reaction.
Medicine of the present invention shows through clinical use: medicine of the present invention is remarkable for the therapeutic effect of PUD, pain relieving and convergence ulcer surface rapidly, and the treatment short treating period, cure rate is high, and side effect is little.Cure 14-20 day after general patient's medication, severe patient 20-30 day cures.
Medicine of the present invention is to the clinical observation on the therapeutic effect of ulcerative colitis.
Physical data:
Accept out-patient's totally 21 examples for medical treatment, wherein male 12 examples, women 9 examples.
Therapeutic Method:
Get this prescription powder 5g and be mixed with suspension with eliminating cold for resuscitation water or normal saline 40ml, retention enema, every day 1-2 time.
The treatment standard:
Patient's pain degree obviously alleviates, and transference cure is observed through colonoscope, the ulcer decreased number, and diameter reduces, the healing of ulcer surface.
Therapeutic outcome (seeing table 3):
Table 3 is observation of curative effect after treatment
The native place Name Sex Age The state of an illness Therapeutic Method The course of treatment Therapeutic outcome
Ma Pingxiao The man The Inner Mongol 53 Colitis 5 years Retention enema once a day 14 days Transference cure is not made colonoscope
Yang Jianping The man The Inner Mongol 55 Colitis 7 years Retention enema once a day 20 days Symptom takes a turn for the better and does not make colonoscope
Li Lifen The man The Inner Mongol 48 Colitis 3 years Retention enema once a day 14 days Transference cure is not made colonoscope
Li Yaping The woman The Inner Mongol 45 Colitis 4 years Retention enema once a day 14 days Transference cure is not made colonoscope
Wang Li The woman The Inner Mongol 40 Colitis 2 years Retention enema once a day 14 days Transference cure is not made colonoscope
Li Wei The man The Inner Mongol 36 Colitis 1 year Retention enema once a day 10 days Transference cure is not made colonoscope
Cui Weibin The man The Inner Mongol 42 Colitis 2 years Retention enema once a day 14 days Transference cure is not made colonoscope
Yang Bo The man The Inner Mongol 38 Colitis 1 year Retention enema once a day 14 days Transference cure is not made colonoscope
Wang Yan The woman The Inner Mongol 36 Colitis 1 year Retention enema once a day 14 days The colonoscopy recovery from illness
Jia Ying The woman The Inner Mongol 35 Colitis 1 year Retention enema once a day 14 days Transference cure is not made colonoscope
Liu Laifu The man The Inner Mongol 49 Colitis 3 years Retention enema once a day 20 days Transference cure is not made colonoscope
Wang Yuchao The man The Inner Mongol 37 Colitis 1 year Retention enema once a day 14 days Transference cure is not made colonoscope
Vast sea The man The Inner Mongol 39 Colitis 2 years Retention enema once a day 14 days Transference cure is not made colonoscope
Li Yanli The woman The Inner Mongol 41 Colitis 2 years Retention enema once a day 14 days Transference cure is not made colonoscope
Liang Yan The woman The Inner Mongol 52 Colitis 3 years Retention enema once a day 14 days Symptom takes a turn for the better and does not make colonoscope
Liu Jingliang The man The Inner Mongol 46 Colitis 1 year Retention enema once a day 14 days The colonoscopy recovery from illness
Guo Min The woman The Inner Mongol 40 Colitis 1 year Retention enema once a day 14 days Transference cure is not made colonoscope
Li Hao The man The Inner Mongol 45 Colitis 1 year Retention enema once a day 14 days Transference cure is not made colonoscope
Deng Chao The man The Inner Mongol 38 Colitis 1 year Retention enema once a day 14 days Transference cure is not made colonoscope
Li Xiaoli The woman The Inner Mongol 35 Colitis 1 year Retention enema once a day 14 days Transference cure is not made colonoscope
Zhao Xianglian The woman The Inner Mongol 39 Colitis 3 years Retention enema once a day 14 days Transference cure is not made colonoscope
Through clinical observation, when medicine of the present invention is processed powder and water or normal saline and is made into suspension retention-enema treatment ulcerative colitis, pain relieving rapidly; Patient affected part pain obviously alleviates, transference cure, per rectum sem observation; The ulcer decreased number, the ulcer surface healing.
Medicine of the present invention shows through clinical use: medicine of the present invention is evident in efficacy for the treatment ulcerative colitis, pain relieving and convergence ulcer surface rapidly, and short treating period, cure rate is high.10-14 day transference cure after general patient's medication, severe patient 14-20 day cures.
The specific embodiment
Below come further to set forth medicine of the present invention through embodiment method for preparing.
Embodiment 1, and the present invention treats the Chinese medicine preparation of ulcer, adopts following components by weight percent preparation: Galla Chinensis 18g, Herba Violae 14g, Herba Taraxaci 14g, Radix Scrophulariae 15g, Rhizoma Coptidis 12g, Radix Scutellariae 24g, Radix Sophorae Tonkinensis 18g, Indigo Naturalis 24g and Borneolum Syntheticum 8g.
Method for preparing:
A) raw material is carried out the strictness screening, purify, oven dry takes by weighing Galla Chinensis 18g, Herba Violae 14g, Herba Taraxaci 14g, Radix Scrophulariae 15g, Rhizoma Coptidis 12g, Radix Scutellariae 24g and Radix Sophorae Tonkinensis 18g, and is subsequent use;
B) the said Galla Chinensis that takes by weighing, Herba Violae, Herba Taraxaci, Radix Scrophulariae, Rhizoma Coptidis, Radix Scutellariae and Radix Sophorae Tonkinensis 7 flavor medicines are inserted in the heater, constantly stir, fry 30 minutes to surperficial yellow, take out subsequent use with slow fire;
C) pulverize with the medical material of electric mill after, be filtered into 800 purpose smalls with square-bottomed bamboo basket with above-mentioned parch;
D) in said smalls, add ground Indigo Naturalis 24g and Borneolum Syntheticum 8g, fully be mixed into drug powder;
E) with said drug powder under aseptic condition, bottle the sealing subsequent use, both KUIYANG SAN powder; Said drug powder is pressed the conventional method for preparing of Chinese medicinal capsule agent under aseptic condition, incapsulate, promptly get Kuiyangsan Capsules, every capsules contains former medicine 0.3g.
Instructions of taking:
Oral ulcer: after the raw material of above-mentioned weight is processed this drug powder, whenever sprayed once spray in day 3-6 time in the affected part at a distance from 4-6 hour.
Ulcerative colitis: get this prescription powder 5g and be mixed with suspension with eliminating cold for resuscitation water or normal saline 40ml, retention enema, every day 1-2 time.
Gastric ulcer: oral after the raw material of above-mentioned weight portion is processed medicine capsule of the present invention, every day 3 times, each 3.
Embodiment 2-3 adopts the feedstock production of following weight portion, method for preparing with take method with embodiment 1.
The component title Embodiment 2 Embodiment 3
Galla Chinensis (g) 10 30
Herba Violae (g) 8 20
Herba Taraxaci (g) 10 18
Radix Scrophulariae (g) 10 20
Rhizoma Coptidis (g) 8 15
Radix Scutellariae (g) 10 30
Radix Sophorae Tonkinensis (g) 10 25
Indigo Naturalis (g) 20 30
Borneolum Syntheticum (g) 6 12

Claims (2)

1. Chinese medicine preparation of treating ulcer is characterized in that it is processed by following materials of weight proportions: Galla Chinensis 10-30g, Herba Violae 8-20g, Herba Taraxaci 10-18g, Radix Scrophulariae 10-20g, Rhizoma Coptidis 8-15g, Radix Scutellariae 10-30g, Radix Sophorae Tonkinensis 10-25g, Indigo Naturalis 20-30g and Borneolum Syntheticum 6-12g.
2. the Chinese medicine preparation of treatment ulcer according to claim 1 is characterized in that the weight proportion of said raw material is: Galla Chinensis 18g, Herba Violae 14g, Herba Taraxaci 14g, Radix Scrophulariae 15g, Rhizoma Coptidis 12g, Radix Scutellariae 24g, Radix Sophorae Tonkinensis 18g, Indigo Naturalis 24g and Borneolum Syntheticum 8g.
CN201010198216A 2010-06-11 2010-06-11 Traditional Chinese preparation for treating ulcers Expired - Fee Related CN102274353B (en)

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Publication number Priority date Publication date Assignee Title
CN102727817B (en) * 2012-07-02 2013-08-07 初晓凌 Oral liquid for treating oral ulcer
CN104288379B (en) * 2014-09-29 2015-07-15 周知航 Traditional Chinese medicine composition for treating dental ulcer
CN106138911A (en) * 2015-04-20 2016-11-23 胡志安 A kind of Chinese herbal medicine pill treating alimentary canal inflammation and ulcer and preparation method

Citations (1)

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CN1457833A (en) * 2003-04-29 2003-11-26 桂林三金药业股份有限公司 Medicinal composition for curing oral and throa diseases and its preparing method, use and quality control method

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