CN1272054C - Medicine for treating diabetes and its preparing process - Google Patents
Medicine for treating diabetes and its preparing process Download PDFInfo
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- CN1272054C CN1272054C CN 200410041598 CN200410041598A CN1272054C CN 1272054 C CN1272054 C CN 1272054C CN 200410041598 CN200410041598 CN 200410041598 CN 200410041598 A CN200410041598 A CN 200410041598A CN 1272054 C CN1272054 C CN 1272054C
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Abstract
The present invention discloses a medicine for treating diabetes, which is mainly formed by that gynura medica, milk vetch, trichosanthin, ophiopogon root, yam, kudzuvine root, cornus officinalis and american ginseng are prepared according to a certain weight proportion and can be prepared into commonly used oral taking capsules or tablets. The medicine of the present invention has the functions of heat clearance, toxicity removal, yin nourishment, dryness moistening, salivation promotion, thirst quenching, blood sugar reduction, dual-directional regulation, fat reduction, blood viscosity reduction, improvement of large, small and micro vascular circulation, etc. The medicine is used for treating yin deficiency excessive heat type dispersion-thirst diseases with the symptoms of thirst with a predilection for cold drink, large food intake with rapid hungering, impatience, irascibility, heat fear, vexation, red urine constipation, red tongue with yellowish fur, etc. is particularly suitable for treating diabetes, hyperlipoidemia and high cholesterol and complications thereof, and has the advantages of obvious effect, good effect without toxic or side effects, etc.
Description
Technical field
The present invention relates to a kind of Chinese medicine medicine for the treatment of diabetes and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Diabetes are multiple difficult miscellaneous diseases of a kind of endocrine metabolism whole body chronic progressive external development, with the hyperglycemia is the syndrome of feature, polyuria is arranged, polydipsia, polyphagia, fatigue and weak, multiple symptom such as lose weight, especially can cause the heart, brain, kidney, eye, chronic vascular lesion and peripheral nerve pathological changes such as foot, thereby take place relevant, corresponding many complication, as hypertension, coronary heart disease, 100 multiple complications such as apoplexy, its harm is more, bigger and more serious, the disability rate height, so that shorten the life-span, can't cure and dead, diabetes about 80% are died from concurrent cardiovascular and cerebrovascular disease.So sick the 3rd the common serious disease that has been listed in the harm humans life and health, No.1 chronic killer.Present antidiabetic drug mainly contains the sulfa drugs that stimulates the β cell, the inhibitor that stops liver to make the biguanides of sugar, stop glycoconjugates to digest, insulinize again when said medicine is invalid, above-mentioned Western medicine all has certain toxic and side effects, and is difficult to obtain promising result.Though among the people have a Chinese herbal medicine secret recipe that much has hypoglycemic lipid-lowering effect, need prepare voluntarily mostly, take after decocting into water preparation, use inconveniently, and effect is also undesirable.
Summary of the invention
Purpose of the present invention is in order to overcome the weak point of said medicine, provides a kind of effect for the treatment of diabetes and complication thereof remarkable, the medicine of taking convenience, the treatment diabetes that have no side effect.
Another object of the present invention has provided the preparation method of this medicine.
Drug main of the present invention will have been selected latest find for use and the medical herbs Gynura Medica of treatment diabetes effect has also been arranged through the folk prescription use, make up with the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni and Radix Panacis Quinquefolii again, extract its effective ingredient, make each efficacy of drugs produce synergism, thereby can effectively treat diabetes and complication thereof.The consumption of this drug component draws through groping in a large number to sum up, and each amounts of components all has curative effect preferably in the following weight parts scope:
Gynura Medica 30-50 part, Radix Astragali 5-15 part, Radix Trichosanthis 5-15 part, Radix Ophiopogonis 5-15 part, Rhizoma Dioscoreae 5-10 part, Radix Puerariae 5-15 part, Fructus Corni 5-10 part and Radix Panacis Quinquefolii 5-10 part.
Be preferably: 5 parts of 40 parts of Gynura Medicas, 11 parts of the Radixs Astragali, 11 parts of Radix Trichosanthis, 11 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 11 parts of Radix Puerariaes, 10 parts of Fructus Corni and Radix Panacis Quinquefoliis.
In order to reach better therapeutic, each amounts of components of medicine of the present invention can also be Gynura Medica 30-50 part, Radix Astragali 5-15 part, Radix Trichosanthis 5-15 part, Radix Ophiopogonis 5-15 part, Rhizoma Dioscoreae 5-10 part, Radix Puerariae 5-15 part, Fructus Corni 5-10 part, Radix Panacis Quinquefolii 5-10 part, Radix Rehmanniae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Coptidis 5-10 part and Radix Salviae Miltiorrhizae 5-10 part.
Be preferably: 5 parts of 40 parts of Gynura Medicas, 11 parts of the Radixs Astragali, 11 parts of Radix Trichosanthis, 11 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 11 parts of Radix Puerariaes, Fructus Corni 10,5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizaes.
Gynura Medica among the present invention, claim medicinal Radix gynurae segeti, clever Radix Notoginseng, Herba Angelicae Keiskei, magical grass again, have heat clearing and inflammation relieving, active promoting blood circulation and function such as blood circulation promoting and blood stasis dispelling, be mainly used in diabetes, blood sugar lowering and two-ways regulation, blood fat reducing, reducing blood viscosity, also can be used for treatment dizzy dizzy, make eye bright, rheumatic arthritis, traumatic injury and carbuncle sore are swollen etc.The test white mice has been carried out toxicity test specially and to the test of white mice blood sugar influence through Chinese medicine institute of China Medicine University in 12-2003 in 2002 fresh leaf that is January medicinal Radix gynurae segeti with Gynura Medica, the result shows, medicinal Radix gynurae segeti 1 or 2 or 4g/kg dosage gastric infusion does not have obvious influence to normal white mice blood glucose; With 2 or 4g/kg dosage gastric infusion, obviously reduce and suffer from the blood sugar level of the white mice of diabetes with the alloxan intravenous injection, be inhibition trend with 1g/kg dosage gastric infusion, show that the too high blood sugar level of diabetes patient is had the improvement effect.The maximum tolerated dose of mouse stomach administration is 38.6g/kg, is equivalent to 102.9 times of day for human beings clothes 22.5g dosage.Illustrate that it is safe taking normal dose.In addition, Gynura Medica is the novel species that Radix gynurae segeti belongs to, see " Radix gynurae segeti one novel species (Compositae) " that China Medicine University poplar Yongkang and Wu Jiakun professor delivered in " Chinese medicine biotechnology applications magazine " the 2nd phase in 2004 for details, it is herbaceos perennial, not anti-frost and snow cold, wild in China south, for medicinal needs, the inventor carries out artificial culture research to Gynura Medica.
Other component among the present invention, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni, Radix Panacis Quinquefolii, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis and Radix Salviae Miltiorrhizae are Chinese medicine.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into conventional oral preparations, but brings into play drug effect better for each crude drug that makes this medicine, and preferred manufacturing procedure is as follows:
A) take by weighing each crude drug Gynura Medica, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni and Radix Panacis Quinquefolii, standby;
B) Gynura Medica, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, the Rhizoma Dioscoreae 5 flavor medicines with described weight proportion decoct with water 3 times, and each amount of water was not advisable to have powder, merged 3 decocting liquids and filtered to get filtrate, and was condensed into the concentrated solution that proportion is 1.2-1.3, got concentrated solution 1;
C) Radix Puerariae of described weight proportion and Fructus Corni are added 70%-95% ethanol and carry out reflux, extract, 3 times, add amount of alcohol at every turn and be not advisable, merge 3 times extracting solution, filter, reclaim ethanol and concentrate to have powder, concentrated solution 2;
D) with concentrated solution 1 and concentrated solution 2 mixings, drying and granulating must be done granule, just has been prepared into active component of the present invention;
E) Radix Panacis Quinquefolii with described weight proportion grinds into impalpable powder, incapsulates with the dried granule mixing of active component of the present invention or uses adjuvant always with tablet and mix the back tabletting and make tablet.
Another preferred manufacturing procedure of the present invention is:
A) take by weighing each crude drug Gynura Medica, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni and Radix Panacis Quinquefolii, standby;
B) Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, the Rhizoma Dioscoreae 4 flavor medicines with described weight proportion decoct with water 3 times, and each amount of water was not advisable to have powder, merged 3 decocting liquids and filtered to get filtrate, and was condensed into the concentrated solution that proportion is 1.2-1.3, got concentrated solution 1;
C) Radix Puerariae of described weight proportion and Fructus Corni are added 70%-95% ethanol and carry out reflux, extract, 3 times, add amount of alcohol at every turn and be not advisable, merge 3 times extracting solution, filter, reclaim ethanol and concentrate to have powder, concentrated solution 2;
D) with concentrated solution 1 and concentrated solution 2 mixings, drying and granulating must be done granule, just has been prepared into active component of the present invention;
E) Gynura Medica with described weight proportion grinds into impalpable powder with Radix Panacis Quinquefolii, incapsulates with the dried granule mixing of active component of the present invention or uses adjuvant always with tablet and mix the back tabletting and make tablet.
If also with Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis and Radix Salviae Miltiorrhizae combination, its preferred manufacturing procedure is:
A) take by weighing each crude drug Gynura Medica, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni, Radix Panacis Quinquefolii, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis and Radix Salviae Miltiorrhizae, standby;
B) Gynura Medica, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Coptidis 8 flavor medicines with described weight proportion decoct with water 3 times, each amount of water was not advisable to have powder, merge 3 decocting liquids and filter to get filtrate, be condensed into the concentrated solution that proportion is 1.2-1.3, get concentrated solution 1;
C) Radix Puerariae, Radix Salviae Miltiorrhizae and the Fructus Corni of described weight proportion added 70%-95% ethanol and carries out reflux, extract, 3 times, add amount of alcohol at every turn and be not advisable, merge 3 times extracting solution, filter, reclaim ethanol and concentrate to have powder, concentrated solution 2;
D) with concentrated solution 1 and concentrated solution 2 mixings, drying and granulating must be done granule, just has been prepared into active component of the present invention;
E) Radix Panacis Quinquefolii with described weight proportion grinds into impalpable powder, incapsulates with the dried granule mixing of active component of the present invention or uses adjuvant always with tablet and mix the back tabletting and make tablet.
Another preferred manufacturing procedure of the present invention is:
A) take by weighing each crude drug Gynura Medica, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni, Radix Panacis Quinquefolii, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis and Radix Salviae Miltiorrhizae, standby;
B) Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Coptidis 7 flavor medicines with described weight proportion decoct with water 3 times, each amount of water was not advisable to have powder, merge 3 decocting liquids and filter to get filtrate, be condensed into the concentrated solution that proportion is 1.2-1.3, get concentrated solution 1;
C) Radix Puerariae, Radix Salviae Miltiorrhizae and the Fructus Corni of described weight proportion added 70%-95% ethanol and carries out reflux, extract, 3 times, add amount of alcohol at every turn and be not advisable, merge 3 times extracting solution, filter, reclaim ethanol and concentrate to have powder, concentrated solution 2;
D) with concentrated solution 1 and concentrated solution 2 mixings, drying and granulating must be done granule, just has been prepared into active component of the present invention;
E) Gynura Medica with described weight proportion grinds into impalpable powder with Radix Panacis Quinquefolii, incapsulates with the dried granule mixing of active component of the present invention or uses adjuvant always with tablet and mix the back tabletting and make tablet.
Medicine of the present invention has heat-clearing and toxic substances removing, nourshing Yin and drynsessmoistening prescription, promoting the production of body fluid to quench thirst, blood sugar lowering and two-ways regulation, blood fat reducing, reducing blood viscosity improves functions such as large and small, blood capillary circulation, be used for the treatment of thirst and desire for cold drink, polyorexia, being irritable and getting angry easily, vexed, the red constipation of urinating that To Be Protected from Heat, intense heat due to deficiency of YIN type diabetes such as red tongue with yellow fur are diabetes.For diabetes, hyperlipidemia and hypercholesterolemia patient, obey 2-3 every day, and each 5 capsules or 5 tablets of tablets are taken and can obviously be reduced in 1 month, and seriously ill patient is dosage suitably, normal after, reduce to 2-3 sheet maintenance dose at every turn.Through on probation to 300 many cases patients, effective percentage is up to 90%.Illustrate as follows to treatment diabetics situation:
Example 1: Zeng, the woman, 83 years old, because of the cerebral thrombosis apoplexy, suddenly mouth was askew, nose is askew, sialorrhea, eyes do not see yet, May 17 calendar year 2001, to examination in hospital, find blood glucose up to 26 mMs/liter, be diagnosed as the severe complications that diabetes cause.Take medicine of the present invention upon somebody's introduction, just be clearly better after 1 month, after 2 months, blood sugar recovery is normal, cerebral thrombosis, nose is not askew, and mouth is not askew yet, and eyes can be seen, can also play card.
Example 2: Chen, the man, 68 years old, found to suffer from diabetes when operating in 92 years, taking multiple antidiabetic drugs such as the two croaks of diformazan, insoral, gliquidone, the two croaks of diformazan does not all have and is clearly better, can only keep by beating insulin, upon somebody's introduction, take medicine of the present invention in October, 02, after 1 month, blood glucose by 9.2 mMs/liter drop to, 6.5 mMs/liter, other index also few by falling more, drops to 4.29 as cholesterol by 5.5, and triglyceride drops to 2.01 by 3.17, pyruvic transaminase drops to 15.3 by 21.8, and mood is happy especially.
Example 3: Yang, the man, 63 years old, find to suffer from diabetes in 83 years, take medicine for a long time and lose effect, be in hospital more than 20 day in 98 years, hung water tens days, early, late venation spirit, does not all have improvement, blood glucose after the meal 16 mMs/liter, lean on the import gliquidone 3 times/day, keep for 2/time.Take medicine of the present invention upon somebody's introduction, 3 times/day, 3 slices/time, survey after 1 month blood glucose drop to 8.9 mMs/liter, conscious health is much better, mouth is not done, defecation is normal, and is happy.
Example 4: high so-and-so, the woman 66 years old, suffers from diabetes more than 7 years, blood glucose 9.2 mMs/liter, the clothes metformin is invalid, and in March, 99 is because of hypertension, cerebral hemorrhage and thrombosis go into hospital, it is all right that thrombosis recovers, and is exactly that blood glucose can fall, and what also dare not be eaten, evening xerostomia, often will drink water, through taking medicine of the present invention, after 1 month, blood glucose has descended, be after meal 6.8 mMs/liter, it is fragrant to have had a meal, defecation is normal, mouth is not done, need not drink water evening, now put down psychological pressure, passes more and more easilyer.
The specific embodiment
Medicine of the present invention can be made with effective component extracting in the following bulk drugs:
1,50 parts of Gynura Medicas, 15 parts of the Radixs Astragali, 15 parts of Radix Trichosanthis, 15 parts of Radix Ophiopogonis, 10 parts of Rhizoma Dioscoreaes, 15 parts of Radix Puerariaes, 10 parts of Fructus Corni and Radix Panacis Quinquefolii are 10 parts.
2,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
3,40 parts of Gynura Medicas, 11 parts of the Radixs Astragali, 11 parts of Radix Trichosanthis, 11 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 11 parts of Radix Puerariaes, 10 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
4,50 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
5,30 parts of Gynura Medicas, 15 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
6,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 15 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
7,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 15 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
8,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 10 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
9,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 15 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
10,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 10 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
11,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 10 parts.
The weight portion of each crude drug of said components all can obtain promising result in Gynura Medica 30-50 part, Radix Astragali 5-15 part, Radix Trichosanthis 5-15 part, Radix Ophiopogonis between 5-15 part, Rhizoma Dioscoreae 5-10 part, Radix Puerariae 5-15 part, Fructus Corni 5-10 part and Radix Panacis Quinquefolii 5-10 part.
In order to make better effects if, medicine of the present invention can also increase Radix Rehmanniae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Coptidis 5-10 part and Radix Salviae Miltiorrhizae 5-10 part on the basis of above-mentioned each ingredients weight parts consumption.Concrete heroic undertaking example is described as follows:
1,50 parts of Gynura Medicas, 15 parts of the Radixs Astragali, 15 parts of Radix Trichosanthis, 15 parts of Radix Ophiopogonis, 10 parts of Rhizoma Dioscoreaes, 15 parts of Radix Puerariaes, 10 parts of Fructus Corni, 10 parts of Radix Panacis Quinquefoliis, 10 parts of Radix Rehmanniae, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 10 parts.
2,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
3,40 parts of Gynura Medicas, 11 parts of the Radixs Astragali, 11 parts of Radix Trichosanthis, 11 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 11 parts of Radix Puerariaes, 10 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
4,50 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni and Radix Panacis Quinquefolii are 5 parts.
5,30 parts of Gynura Medicas, 15 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
6,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 15 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
7,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 15 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
8,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 10 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
9,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 15 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
10,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 10 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
11,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 10 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
12,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 10 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
13,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
14,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 5 parts.
15,30 parts of Gynura Medicas, 5 parts of the Radixs Astragali, 5 parts of Radix Trichosanthis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Radix Puerariaes, 5 parts of Fructus Corni, 5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizae are 10 parts.
Be preferably: 5 parts of 40 parts of Gynura Medicas, 11 parts of the Radixs Astragali, 11 parts of Radix Trichosanthis, 11 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 11 parts of Radix Puerariaes, Fructus Corni 10,5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizaes.
After above-mentioned each crude drug weighed up, by above-mentioned preparation method respectively through water carry with alcohol extraction after make dried granule, incapsulate or mix afterwards tabletting with tablet adjuvant commonly used and make tablet again with behind Radix Panacis Quinquefolii fine powder or Gynura Medica and the Radix Panacis Quinquefolii fine powder mix homogeneously.
Claims (8)
1, a kind of medicine for the treatment of diabetes is characterized in that making that main medicine in the raw material of this pharmaceutically active ingredient is formed and weight portion is: medicinal Radix gynurae segeti 30-50 part, Radix Astragali 5-15 part, Radix Trichosanthis 5-15 part, Radix Ophiopogonis 5-15 part, Rhizoma Dioscoreae 5-10 part, Radix Puerariae 5-15 part, Fructus Corni 5-10 part and Radix Panacis Quinquefolii 5-10 part.
2, the medicine of treatment diabetes as claimed in claim 1 is characterized in that the consumption of each crude drug is: 5 parts of 40 parts of medicinal Radix gynurae segeti, 11 parts of the Radixs Astragali, 11 parts of Radix Trichosanthis, 11 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 11 parts of Radix Puerariaes, 10 parts of Fructus Corni and Radix Panacis Quinquefoliis.
3, the preparation method of claim 1 or 2 described medicines is characterized in that comprising the following steps:
A) take by weighing the medicinal Radix gynurae segeti of each crude drug, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni and Radix Panacis Quinquefolii, standby;
B) medicinal Radix gynurae segeti, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, the Rhizoma Dioscoreae 5 flavor medicines with described weight proportion decoct with water 3 times, and each amount of water was not advisable to have powder, merged 3 decocting liquids and filtered to get filtrate, and was condensed into the concentrated solution that proportion is 1.2-1.3, got concentrated solution 1;
C) Radix Puerariae of described weight proportion and Fructus Corni are added 70%-95% ethanol and carry out reflux, extract, 3 times, add amount of alcohol at every turn and be not advisable, merge 3 times extracting solution, filter, reclaim ethanol and concentrate to have powder, concentrated solution 2;
D) with concentrated solution 1 and concentrated solution 2 mixings, drying and granulating must be done granule, just has been prepared into active component of the present invention;
E) Radix Panacis Quinquefolii with described weight proportion grinds into impalpable powder, incapsulates with the dried granule mixing of active component of the present invention or uses adjuvant always with tablet and mix the back tabletting and make tablet.
4, the preparation method of claim 1 or 2 medicine, it comprises the following steps:
A) take by weighing the medicinal Radix gynurae segeti of each crude drug, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni and Radix Panacis Quinquefolii, standby;
B) Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, the Rhizoma Dioscoreae 4 flavor medicines with described weight proportion decoct with water 3 times, and each amount of water was not advisable to have powder, merged 3 decocting liquids and filtered to get filtrate, and was condensed into the concentrated solution that proportion is 1.2-1.3, got concentrated solution 1;
C) Radix Puerariae of described weight proportion and Fructus Corni are added 70%-95% ethanol and carry out reflux, extract, 3 times, add amount of alcohol at every turn and be not advisable, merge 3 times extracting solution, filter, reclaim ethanol and concentrate to have powder, concentrated solution 2;
D) with concentrated solution 1 and concentrated solution 2 mixings, drying and granulating must be done granule, just has been prepared into active component of the present invention;
E) the medicinal Radix gynurae segeti with described weight proportion grinds into impalpable powder with Radix Panacis Quinquefolii, incapsulates with the dried granule mixing of active component of the present invention or uses adjuvant always with tablet and mix the back tabletting and make tablet.
5, the medicine of treatment diabetes as claimed in claim 1 is characterized in that crude drug also has: Radix Rehmanniae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Coptidis 5-10 part and Radix Salviae Miltiorrhizae 5-10 part.
6, medicine as claimed in claim 5, wherein the consumption of each component is: 5 parts of 40 parts of medicinal Radix gynurae segeti, 11 parts of the Radixs Astragali, 11 parts of Radix Trichosanthis, 11 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 11 parts of Radix Puerariaes, Fructus Corni 10,5 parts of Radix Panacis Quinquefoliis, 5 parts of Radix Rehmanniae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Coptidis and Radix Salviae Miltiorrhizaes.
7, the preparation method of claim 5 or 6 medicine, it comprises the following steps:
A) take by weighing the medicinal Radix gynurae segeti of each crude drug, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni, Radix Panacis Quinquefolii, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis and Radix Salviae Miltiorrhizae, standby;
B) medicinal Radix gynurae segeti, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Coptidis 8 flavor medicines with described weight proportion decoct with water 3 times, each amount of water was not advisable to have powder, merge 3 decocting liquids and filter to get filtrate, be condensed into the concentrated solution that proportion is 1.2-1.3, get concentrated solution 1;
C) Radix Puerariae, Fructus Corni and the Radix Salviae Miltiorrhizae of described weight proportion added 70%-95% ethanol and carries out reflux, extract, 3 times, add amount of alcohol at every turn and be not advisable, merge 3 times extracting solution, filter, reclaim ethanol and concentrate to have powder, concentrated solution 2;
D) with concentrated solution 1 and concentrated solution 2 mixings, drying and granulating must be done granule, just has been prepared into active component of the present invention;
E) Radix Panacis Quinquefolii with described weight proportion grinds into impalpable powder, incapsulates with the dried granule mixing of active component of the present invention or uses adjuvant always with tablet and mix the back tabletting and make tablet.
8, the preparation method of claim 5 or 6 medicine, it comprises the following steps:
A) take by weighing the medicinal Radix gynurae segeti of each crude drug, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Puerariae, Fructus Corni, Radix Panacis Quinquefolii, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis and Radix Salviae Miltiorrhizae, standby;
B) Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, Rhizoma Dioscoreae, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Coptidis 7 flavor medicines with described weight proportion decoct with water 3 times, each amount of water was not advisable to have powder, merge 3 decocting liquids and filter to get filtrate, be condensed into the concentrated solution that proportion is 1.2-1.3, get concentrated solution 1;
C) Radix Puerariae, Fructus Corni and the Radix Salviae Miltiorrhizae of described weight proportion added 70%-95% ethanol and carries out reflux, extract, 3 times, add amount of alcohol at every turn and be not advisable, merge 3 times extracting solution, filter, reclaim ethanol and concentrate to have powder, concentrated solution 2;
D) with concentrated solution 1 and concentrated solution 2 mixings, drying and granulating must be done granule, just has been prepared into active component of the present invention;
E) the medicinal Radix gynurae segeti with described weight proportion grinds into impalpable powder with Radix Panacis Quinquefolii, incapsulates with the dried granule mixing of active component of the present invention or uses adjuvant always with tablet and mix the back tabletting and make tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410041598 CN1272054C (en) | 2004-08-04 | 2004-08-04 | Medicine for treating diabetes and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410041598 CN1272054C (en) | 2004-08-04 | 2004-08-04 | Medicine for treating diabetes and its preparing process |
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| Publication Number | Publication Date |
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| CN1602921A CN1602921A (en) | 2005-04-06 |
| CN1272054C true CN1272054C (en) | 2006-08-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410041598 Expired - Fee Related CN1272054C (en) | 2004-08-04 | 2004-08-04 | Medicine for treating diabetes and its preparing process |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156108B (en) * | 2013-04-02 | 2015-03-18 | 曾晓飞 | Fortified food for preventing and treating diabetes mellitus and hypertension diseases |
| CN103301202B (en) * | 2013-06-28 | 2015-06-03 | 苏州菩芸生物科技有限公司 | Chinese herbal medicine formula for assisting hypoglycemic |
| CN104829736A (en) * | 2015-04-13 | 2015-08-12 | 盐城工学院 | Gynura medica polysaccharide, preparation method and applications thereof |
| CN107126501A (en) * | 2017-04-12 | 2017-09-05 | 合肥海大生物医药科技有限公司 | It is a kind of to treat Chinese medicine composition of diabetes and preparation method thereof |
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