CN107126501A - It is a kind of to treat Chinese medicine composition of diabetes and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of diabetes and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of Chinese medicine composition for treating diabetes and preparation method thereof.The Chinese medicine composition is by radix rehmanniae recen, Chinese yam rhizome, the red sage root, Radix Codonopsis, Radix Angelicae Sinensis, the root of bidentate achyranthes, red spoon, hairyvein agrimony, the Radix Astragali, and the tuber of dwarf lilyturf, root of Chinese trichosanthes, the coptis is raw material, is prepared from by certain weight, and it can be prepared into any conventional oral formulations.This product has the effect of reinforcing both QI and YIN, spleen kidney are double strong, promoting blood circulation and removing blood stasis.Clinically it is used to treat diabetes, it is evident in efficacy, clinically without bad toxic side effect.
Description
Technical field
The present invention is to be related to a kind of Chinese medicine composition, specifically, is related to the Chinese medicine composition and its system of a kind of diabetes
Preparation Method.
Background technology
According to the newest announcement data display of the World Health Organization, diabetes turn into except cardiovascular and cerebrovascular disease, malignant tumour with
Outer the third-largest disease.And China has turned into the first in the world diabetes big country, illness rate is 9.7%, higher than world standard
6.4%.Most troubling is that more than 18 years old resident of China is 36.1% for diabetes awareness.
Diabetes, the traditional Chinese medical science claims " quenching one's thirst ", is a kind of metabolic disease of puzzlement human lives serious from ancient times to the present.Diabetes
Itself is fearful, and fearful is a series of thus caused complication.Such as cardiovascular and cerebrovascular disease, eyeground pathological changes, peripheral nerve
Four limbs fester caused by lesion.It is a process slowly developed from diabetes to complication, Most patients can not all hide
Past, the incidence of complication can exceed that 80%.But, if can as early as possible find and make a definite diagnosis diabetes, intervene in advance, being can
To prevent disease.
At present, most of diabetics rely primarily on OHA and insulin to treat.These medicines are to person in middle and old age
For patient, lactic acidosis, hypoglycemia are easily caused, because scrupling in this, it has to reduce control standard, cause complication to be sent out
Hair tonic exhibition, the treatment to these complication is more intractable, therefore seeks safely and effectively hypoglycemic, the method for preventing complication, as wide
The common aspiration of big diabetic and doctor.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating diabetes.
The present invention also aims to provide a kind of Chinese medicine composition for treating diabetes and preparation method thereof.
The scheme that the present invention is solved is inventor, under the guidance of traditional Chinese medical theory, many for the pathogenetic mechanism of glycosuria
The clinical experience of oneself is combined over year, is developed meticulously, this product has the double strong, work(promoting blood circulation and removing blood stasis of reinforcing both QI and YIN, spleen kidney
Effect.Clinically it is used to treat diabetes, it is evident in efficacy, clinically without bad toxic side effect.
The present invention realizes that medicine of the present invention is mainly the bulk drug system matched by following weight parts by following scheme
Into：
The preferred weight part of the main each raw material of medicine of the present invention is matched：
The optimum weight part of the main each raw material of medicine of the present invention is matched：
15 parts of radix rehmanniae recen, 15 parts of Chinese yam rhizome, 20 parts of the red sage root, 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of bidentate achyranthes, 15 parts of the radix paeoniae rubrathe is celestial
18 parts of crane grass, 18 parts of the Radix Astragali, 15 parts of the tuber of dwarf lilyturf, 15 parts of root of Chinese trichosanthes, 6 parts of the coptis.
The preparation method of medicine of the present invention, its method and step is as follows：
(1) by the radix rehmanniae recen of weight described in formula, Chinese yam rhizome, the red sage root, Radix Codonopsis, Radix Angelicae Sinensis, the root of bidentate achyranthes, the radix paeoniae rubrathe is celestial
Crane grass, the Radix Astragali, the tuber of dwarf lilyturf, root of Chinese trichosanthes, the coptis adds water to cook secondary, each plus 6-10 times of water measured, each 1-2 hours, merges and decocts
Liquid, filtration, filtrate is concentrated into the medicinal extract that relative density is 1.15~1.20 (80 DEG C)；
(2) add ethanol in medicinal extract, it is 50-90% to make alcohol content, is stirred evenly, stand 24-48 hours, take supernatant, reclaim
Ethanol is concentrated into the medicinal extract that density is 1.25~1.30 (80 DEG C), for preparing various preparations.
Auxiliary material required when preparing different dosage forms can be added in the concentrate that the present invention is extracted, then with conventional Chinese medicine
Formulation method is prepared into conventional peroral dosage form, such as capsule, granule, tablet.
Embodiment
Embodiment 1：A kind of capsule preparation method thereof for treating diabetes of the present invention, its step is as follows：
15 parts of radix rehmanniae recen, 15 parts of Chinese yam rhizome, 20 parts of the red sage root, 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of bidentate achyranthes, 15 parts of the radix paeoniae rubrathe is celestial
18 parts of crane grass, 18 parts of the Radix Astragali, 15 parts of the tuber of dwarf lilyturf, 15 parts of root of Chinese trichosanthes, 6 parts of the coptis.
(1) by the radix rehmanniae recen of weight described in formula, Chinese yam rhizome, the red sage root, Radix Codonopsis, Radix Angelicae Sinensis, the root of bidentate achyranthes, the radix paeoniae rubrathe is celestial
Crane grass, the Radix Astragali, the tuber of dwarf lilyturf, root of Chinese trichosanthes, the coptis add water to cook it is secondary, every time plus 8 times amount water, 1.5 hours every time, collecting decoction,
Filtration, filtrate is concentrated into the medicinal extract that relative density is 1.15~1.20 (80 DEG C)；
(2) add ethanol in medicinal extract, it is 70% to make alcohol content, is stirred evenly, stand 24 hours, take supernatant, reclaim ethanol dense
It is reduced to the medicinal extract that density is 1.25~1.30 (80 DEG C), adds microcrystalline cellulose, mix, dry, pulverize into fine powder, loads glue
Capsule, produces capsule.
Embodiment 2：A kind of process for producing granula for treating diabetes of the present invention, its step is as follows：
15 parts of radix rehmanniae recen, 15 parts of Chinese yam rhizome, 20 parts of the red sage root, 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of bidentate achyranthes, 15 parts of the radix paeoniae rubrathe is celestial
18 parts of crane grass, 18 parts of the Radix Astragali, 15 parts of the tuber of dwarf lilyturf, 15 parts of root of Chinese trichosanthes, 6 parts of the coptis.
(1) by the radix rehmanniae recen of weight described in formula, Chinese yam rhizome, the red sage root, Radix Codonopsis, Radix Angelicae Sinensis, the root of bidentate achyranthes, the radix paeoniae rubrathe is celestial
Crane grass, the Radix Astragali, the tuber of dwarf lilyturf, root of Chinese trichosanthes, the coptis adds water to cook secondary, each plus 10 times of amounts water, 1 hour every time, collecting decoction, filter
Cross, filtrate is concentrated into the medicinal extract that relative density is 1.15~1.20 (80 DEG C)；
(2) add ethanol in medicinal extract, it is 90% to make alcohol content, is stirred evenly, stand 48 hours, take supernatant, reclaim ethanol dense
It is reduced to the medicinal extract that density is 1.25~1.30 (80 DEG C), adds dextrin, Steviosin, mixing, pelletize, dries, that is, particle is made
Agent.
Embodiment 3：A kind of method for preparing tablet thereof for treating diabetes of the present invention, its step is as follows：
15 parts of radix rehmanniae recen, 15 parts of Chinese yam rhizome, 20 parts of the red sage root, 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of bidentate achyranthes, 15 parts of the radix paeoniae rubrathe is celestial
18 parts of crane grass, 18 parts of the Radix Astragali, 15 parts of the tuber of dwarf lilyturf, 15 parts of root of Chinese trichosanthes, 6 parts of the coptis.
(1) by the radix rehmanniae recen of weight described in formula, Chinese yam rhizome, the red sage root, Radix Codonopsis, Radix Angelicae Sinensis, the root of bidentate achyranthes, the radix paeoniae rubrathe is celestial
Crane grass, the Radix Astragali, the tuber of dwarf lilyturf, root of Chinese trichosanthes, the coptis adds water to cook secondary, each plus 6 times of amounts water, 2 hours every time, collecting decoction, filter
Cross, filtrate is concentrated into the medicinal extract that relative density is 1.15~1.20 (80 DEG C)；
(2) add ethanol in medicinal extract, it is 50% to make alcohol content, is stirred evenly, stand 24 hours, take supernatant, reclaim ethanol dense
It is reduced to the medicinal extract that density is 1.25~1.30 (80 DEG C), adds microcrystalline cellulose, magnesium stearate mixes and particle is made, tabletting,
It is coated, produces tablet.
By clinic application, clinic does not find any toxic side effect to we for treatment diabetes curative effect significantly.
Experimental example
Case 1：Zhang, female, 65 years old.Suffer from diabetes 3 years, because no medication aggravates disease over nearly 1 month, once clothes disappeared
Thirsty ball, the medicine such as Diamicron, glycemic control is undesirable.Examine and see：Spiritlessness and weakness, sound is humble, dry happiness drink, diuresis, many foods, after food
Abdominal distension, and it is often dizzy, and not well, red tongue body of defecating, the thin Huang of tongue, arteries and veins is thin.Fasting blood-glucose 19.3mmol/L, glucose in urine (++++).Orally
Embodiment 1：Capsule, 4 every time, 3 times a day, and symptom subtracts greatly " more than three " after 5 days, fasting blood-glucose 11.6mmol/L, glucose in urine drop
For (++).After 15 days, all diseases disappear, and fasting blood-glucose is reduced to 7.5mmol/L, and glucose in urine switchs to (-).1 month is even served again, glucose in urine (-)
And fully recover.
Although being above described in detail with a general description of the specific embodiments to the present invention,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (4)
1. a kind of Chinese medicine composition for treating diabetes, it is characterised in that it is mainly by the bulk drug system of following weight
Into：
2. a kind of Chinese medicine composition for treating diabetes according to claim 1, it is characterised in that it is mainly by following
It is preferred that the bulk drug of weight be made：
3. a kind of Chinese medicine composition for treating diabetes according to claim 1, it is characterised in that it is mainly by following
The bulk drug of optimum weight part proportioning is made：
15 parts of radix rehmanniae recen, 15 parts of Chinese yam rhizome, 20 parts of the red sage root, 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of bidentate achyranthes, 15 parts of the radix paeoniae rubrathe, hairyvein agrimony
18 parts, 18 parts of the Radix Astragali, 15 parts of the tuber of dwarf lilyturf, 15 parts of root of Chinese trichosanthes, 6 parts of the coptis.
4. one kind according to claim 1 or 2 or 3 treats diabetes medicament preparation method, it is characterised in that under it includes
Row step：
(1) by the radix rehmanniae recen of weight described in formula, Chinese yam rhizome, the red sage root, Radix Codonopsis, Radix Angelicae Sinensis, the root of bidentate achyranthes, red spoon, hairyvein agrimony,
The Radix Astragali, the tuber of dwarf lilyturf, root of Chinese trichosanthes, the coptis adds water to cook secondary, each plus 6-10 times of water measured, each 1-2 hours, collecting decoction, filter
Cross, filtrate is concentrated into the medicinal extract that relative density is 1.15~1.20 (80 DEG C)；
(2) add ethanol in medicinal extract, it is 50-90% to make alcohol content, is stirred evenly, stand 24-48 hours, take supernatant, reclaim ethanol
It is concentrated into the medicinal extract that density is 1.25~1.30 (80 DEG C), addition prepares auxiliary material required during different dosage forms, then with routine
Method of Chinese medicinal be prepared into conventional peroral dosage form, such as capsule, granule, tablet.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107669860A (en) * | 2017-09-26 | 2018-02-09 | 河南大学 | A kind of Chinese medicine composition and its application with blood sugar reducing function |
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