CN1264539A

CN1264539A - Weakly acidic disinfectant

Info

Publication number: CN1264539A
Application number: CN 99100856
Authority: CN
Inventors: 崔永成; 刘亮
Original assignee: Individual
Current assignee: Individual
Priority date: 1999-02-26
Filing date: 1999-02-26
Publication date: 2000-08-30
Also published as: AU2792400A; CN1293540A; WO2000051434A1

Abstract

A weakly acidic disinfectant is prepared from agent A (2-25 wt. portions) of hypochlorite (2-25) and surfactant (0-10) and agent B (2-75 wt. portions) of pH regulator (1.5-74) and stabilizer (0.5-15) through dissolving agent A and agent B in water to obtain aqueous solution with pH value of 3-7. The disinfectant of the invention, after being dissolved in water under the weak acidic condition, generates hypochlorous acid with higher sterilization effect by more than 80%, greatly improves the sterilization effect, and reduces the concentration of available chlorine to below 300ppm during use, thereby reducing the cost.

Description

Weakly acidic disinfectant

The invention relates to a disinfectant, in particular to a faintly acid disinfectant.

At present, one of the most widely used disinfectants is hypochlorite, including sodium hypochlorite or calcium hypochlorite and the like, which has the advantages of wide sterilization spectrum, low price, convenient use and the like, but the pH value of the aqueous solution of the commonly used hypochlorite disinfectant is about 8, the hypochlorite disinfectant is alkaline, and hypochlorite generates more hypochlorite ions OCl after being dissolved in water under the alkaline condition^-Only a small amount of HOCl hypochlorite is present, and the bactericidal effect of HOCl hypochlorite is hypochlorite ion OCl^-80 times of the concentration of the chlorine in the alkaline environment, the concentration needs to be increased to achieve effective sterilization effect, the concentration of the available chlorine generally reaches about 1000ppm, the cost is increased due to the higher concentration, and the chlorine is inevitably released to generate stronger stimulation to the skin, soft tissues and mucous membranes of people.

The present inventors have conducted long-term studies and experiments on the above-mentioned defects, and have created a technical solution of the present invention.

The invention aims to provide a weakly acidic disinfectant, which is prepared by adding a pH regulator and a stabilizer into hypochlorite, overcomes the defects of the prior art, and achieves the purposes of improving the sterilization effect, increasing the stability and reducing the stimulation effect.

The purpose of the invention is realized as follows: a weakly acidic disinfectant, characterized in that: the disinfectant is prepared by packaging an agent A and an agent B in a binary way (parts by weight) according to the following components and proportions:

2-25 parts of A agent, wherein 2-25 parts of hypochlorite and 0-10 parts of surfactant;

agent B2-75, wherein the PH regulator is 1.5-74, and the stabilizer is 0.5-15;

the pH of the aqueous solution of the agent A and the agent B after being dissolved in water is 3 to 7.

The hypochlorite comprises sodium hypochlorite and calcium hypochlorite; the surfactant comprises an anionic surfactant or/and a nonionic surfactant, the anionic surfactant comprises carboxylate, sulfate and phosphate, the nonionic surfactant comprises ester type, ether type and amide type, and commonly used fatty acid glycol ester, fatty alcohol-polyoxyethylene ether and alkylolamide; the pH regulator comprises inorganic acid and/or organic acid; the stabilizer comprises sodium chloride, potassium chloride, calcium chloride, sodium sulfate, sodium pyrophosphate and sodium carbonate; the pH value of the aqueous solution of the agent A and the agent B after being dissolved in water is 4-6, and the concentration of effective chlorine is 10-300 ppm.

The main advantages of the invention are:

1. the disinfectant of the invention adds the PH regulator into the hypochlorite to lead the PH value of the aqueous solution to be 3-7, and the hypochlorite generates hypochlorous acid HOCl with higher sterilization effect of more than 80 percent after being dissolved in water under the weak acidic condition, thereby greatly improving the sterilization effect, reducing the concentration of effective chlorine to be less than 300ppm during the use and further reducing the cost.

2. In the disinfectant, the surfactant is added, so that the osmosis is increased, the disinfection time is shortened, and the effect is improved.

3. The inorganic salt stabilizer is added into the disinfectant, so that the stability of the hypochlorous acid HOCl is improved, the effective chlorine concentration in the solution is lower and is between 10 and 300ppm when the disinfectant is used, the cost is reduced, chlorine is rarely released, irritation is not generated to eyeballs, mucous membranes and the like, and the harm to users is reduced.

The invention will be further described with reference to the preferred embodiments and the accompanying drawings as follows:

FIG. 1 is a graph showing the pH value of hypochlorous acid concentration in the test.

Example 1

The proportion of the solid binary packaging preparation of the weakly acidic disinfectant of the invention is as follows:

0.6 g of agent A, wherein the sodium hypochlorite is 0.58 g, and the sodium dodecyl sulfate is 0.02 g;

1.0 g of agent B, wherein the weight of succinic acid is 0.97 g, the weight of formic acid is 0.015 g, the weight of sodium chloride is 0.005 g, and the weight of sodium sulfate is 0.01 g;

the agent B package can be placed into the agent A package to form an integrated package.

When in use, the agent A is dissolved in water, and the agent B is dissolved in the water and stirred uniformly to obtain the weak acid disinfection solution with the pH value of 3-7. Can be diluted with water to a desired concentration according to the requirements of application, such as medical disinfection or sterilization, the concentration of effective chlorine can be between 60 and 300ppm percent, and if the water is used for indoor or object surface disinfection, the concentration of the effective chlorine can be below 40 ppm.

Example 2

5 g of agent A, wherein the weight of sodium hypochlorite is 4.5 g, the weight of calcium hypochlorite is 0.35 g, and the weight of sodium dodecyl benzene sulfonate is 0.15 g;

7 g of the agent B, wherein 6 g of citric acid, 0.5 g of potassium chloride and 0.5 g of sodium sulfate are contained.

The method of use is the same as in example 1 and is not repeated.

Example 3

1.23 g of agent A, wherein sodium hypochlorite is 1.21 g, and sodium alkylphosphate is 0.02 g;

2.27 g of the agent B, wherein the weight of succinic acid is 2.14 g, the weight of calcium chloride is 0.01 g, and the weight of sodium sulfate is 0.04 g.

The method of use is the same as in example 1 and is not repeated.

Example 4

2.64 g of agent A, wherein the sodium hypochlorite is 2.62 g, and the stearic acid glycol ester active agent is 0.02 g;

4.36 g of the agent B, wherein the malic acid is 4.30 g, the potassium chloride is 0.02 g, and the sodium sulfate is 0.04 g.

The method of use is the same as in example 1 and is not repeated.

Example 5

Hypochlorite concentration variation test at different pH.

For example, sodium hypochlorite, dissolved in water at a pH of about 8, immediately hydrolyzes-OCl^-、H⁺、Na⁺The hydrolysis equation is:

wherein hypochlorite is OCl^-Producing a bactericidal effect.

When acid is added to adjust pH to 3-7, sodium hypochlorite is dissolved in acidic aqueous solution to generate stable HOCl and Na⁺The hydrolysis equation is: the test shows that the sterilizing effect of the HOCl is OCl^-The ratio of the pH regulator to the hypochlorite is 80 times that of the hypochlorite, so that the aqueous solution is weakly acidic after the pH regulator is added into the hypochlorite, HOCl with strong sterilization capability is generated, and the sterilization effect is greatly improved.

When the concentration of the acid in the aqueous solution is further increased to be strongly acidic, that is, when the pH is 3 or less, the concentration of HOCl is decreased by the oxidation potential measurement, which proves that: HOCl is unstable under strongly acidic conditions. Experiments have thus shown that hypochlorite has the strongest bactericidal effect at a weak acid condition of pH3-7, preferably pH 4-6.

The results of the above tests can be further demonstrated by the following experiments, in which Cl is added²Dissolved in water and having a hydrolysis equation of Gradually adding alkali to increase pH, and measuring Cl in the solution at different pH values²HOCl, and OCl^-The results are shown in FIG. 1:

when the pH is 1, the solution is strongly acidic, Cl²The content is more than 70 percent, and the HOCl content is less than 30 percent;

when the pH is 2, the solution is strongly acidic, Cl²The content is below 30 percent, and the HOCl content is about 70 percent;

when the pH is 3, the solution is weakly acidic, Cl²The content is below 10%, and the content of HOCl is above 90%;

when the pH is 4-5, the solution is weakly acidic, Cl²Very small amounts, with an HOCl content of about 99%;

when the pH is 7, the solution is weakly acidic, OCl^-The content is about 20 percent, and the content of HOCl is more than 80 percent;

when the pH is 8, the solution is alkaline, OCl²The content is more than 80 percent, and the content of HOCl is less than 20 percent;

from the above tests it was demonstrated that: when the PH is 3-7, the content of HOCl is stabilized to be more than 80 percent;

particularly, the content of HOCl was stabilized almost at 99% at a pH of 4 to 6.

The above test results further demonstrate that: when the adjusting solution is weakly acidic, i.e., when the pH value is 3-7, HOCl with strong bactericidal effect stably exists.

Example 6

Hypochlorite bactericidal efficacy test under different PH conditions.

The experimental method comprises the following steps: dissolving sodium hypochlorite in water to prepare an aqueous solution with the effective chlorine concentration of 1000ppm, and adjusting the pH value to respectively test HOCl and OCl^-The percentage content and the time required for killing 99 percent of spores are as follows:

the results are shown in Table 1:

TABLE 1 Sterilization efficacy of sodium hypochlorite at different pH values

Test No	PH	HOCl(％)	OCl^-(％)	99% of spore killing time (minute)
Test No	PH	HOCl(％)	OCl^-(％)	99% of spore killing time (minute)	1	10.0	0.3	99.7	120.0
2	9.8	2.9	97.1	19.5	1	10.0	0.3	99.7	120.0
2	9.8	2.9	97.1	19.5	3	8.0	23.2	76.8	5.0
4	7.0	80.0	20.0	3.5	3	8.0	23.2	76.8	5.0
4	7.0	80.0	20.0	3.5	5	6.0	96.8	3.2 3.2	2.5
6	5.0	98.1	1.9	2.0	5	6.0	96.8	3.2 3.2	2.5
6	5.0	98.1	1.9	2.0	7	5.0	96.2	3.8	2.5
8	4.0	91.5	8.5	3.0	7	5.0	96.2	3.8	2.5
8	4.0	91.5	8.5	3.0	9	3.5	90.0	10.0	4.5

The test results show that:

1. runs Nos. 1 and 3, pH 10-8, the solution had less than 3% HOCl, and OCl^-The concentration of (A) is more than 97%, the sterilization time is longer, and the sterilization effect is poor.

2. Run Nos. 4-9, pH 7.0-3.5, HOCl concentration in solution was above 80%, and OCl^-The concentration of (A) is below 20%, the sterilization time is short, and the sterilization effect is remarkably improved.

Example 7

The bactericidal effect of the weakly acidic disinfectant of the present invention was tested.

The sterilizing effect of the weakly acidic disinfectant is detected by the national ministry of health disinfection detection center, the weakly acidic disinfectant and the common sodium hypochlorite disinfectant are prepared into solutions with various concentrations, the time required for completely killing germs is measured, and the result is shown in table 2.

TABLE 2 time (minutes) required for the disinfectant to completely kill germs

Disinfectant Name (R)	pH value	Available chlorine Concentration of ppm	Large intestine Bacillus 8099	For hepatitis B virus surface Destructive action of antigen	Bacillus subtilis Spore of black varietal ATCC9372	Staphylococcus aureus ATCC6578
Disinfectant Name (R)	pH value	Available chlorine Concentration of ppm	Large intestine Bacillus 8099	For hepatitis B virus surface Destructive action of antigen	Bacillus subtilis Spore of black varietal ATCC9372	Staphylococcus aureus ATCC6578	Hypochlorous acid Sodium salt	8-10	200 1000 2000	- 20-30 10-20	- 60 40	- 60-120 40-60	- 20-30 15-25
According to the invention Disinfectant	4-6.8	40 80 200 300	20 15 10 5	15 15 10 5	60-120 40-50 35-45 20-30	20 15 10 5	Hypochlorous acid Sodium salt	8-10	200 1000 2000	- 20-30 10-20	- 60 40	- 60-120 40-60	- 20-30 15-25

Note: wherein "one" means that the germs cannot be completely killed.

The test results show that the weak acid disinfectant of the invention has better efficacy than the common sodium hypochlorite disinfectant with higher concentration such as 2000ppm at lower concentration such as 40 ppm. The weak acidic disinfectant of the invention is proved to greatly improve the sterilization effect.

Example 8

The stability test of the weakly acidic disinfectant of the invention.

The stability of the weakly acidic disinfectant is determined by the national ministry of health disinfection inspection center, and the result shows that the solid binary package storage period is unchanged for two years, and the prepared aqueous solution is unchanged for 20-30 days, which indicates that the weakly acidic disinfectant has better stability.

Claims

1. A weakly acidic disinfectant, characterized in that: the disinfectant is prepared by packaging an agent A and an agent B in a binary way (parts by weight) according to the following components and proportions:

2-75 parts of agent B, wherein the PH regulator is 1.5-74 parts, and the stabilizer is 0.5-15 parts;

the pH value of the aqueous solution of the agent A and the agent B after being dissolved in water is 3-7.

2. A weakly acidic disinfectant as claimed in claim 1 wherein: the hypochlorite includes sodium hypochlorite and calcium hypochlorite.

3. A weakly acidic disinfectant as claimed in claim 1 wherein: the surfactant comprises an anionic surfactant and/or a nonionic surfactant.

4. A weakly acidic disinfectant as claimed in claim 1 wherein: the pH adjusting agent includes an inorganic acid and/or an organic acid.

5. A weakly acidic disinfectant as claimed in claim 1 wherein: the stabilizer comprises sodium chloride, potassium chloride, calcium chloride, sodium sulfate, sodium pyrophosphate and sodium carbonate.

6. A weakly acidic disinfectant as claimed in claim 1 wherein: the PH value of the aqueous solution of the agent A and the agent B after being dissolved in water is 4-6, and the concentration of the available chlorine is 10-300 ppm.

7. A weakly acidic disinfectant as claimed in claim 1 wherein: the disinfectant comprises the following binary packaging components in parts by weight:

1.0 g of agent B, wherein the succinic acid is 0.97 g, the fruit acid is 0.015 g, the sodium chloride is 0.005 g, and the sodium sulfate is 0.01 g.

8. A weakly acidic disinfectant as claimed in claim 1 wherein: the disinfectant comprises the following binary packaging components in parts by weight:

5 g of A agent, wherein 4.5 g of sodium hypochlorite, 0.35 g of calcium hypochlorite and 0.15 g of sodium dodecyl benzene sulfonate;

7 g of the agent B, wherein the citric acid is 6 g, the potassium chloride is 0.5 g, and the sodium sulfate is 0.5 g.