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CN1228067C - Biochemical medicament of araliaceae plant and its preparation method - Google Patents

Biochemical medicament of araliaceae plant and its preparation method Download PDF

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Publication number
CN1228067C
CN1228067C CN 02144848 CN02144848A CN1228067C CN 1228067 C CN1228067 C CN 1228067C CN 02144848 CN02144848 CN 02144848 CN 02144848 A CN02144848 A CN 02144848A CN 1228067 C CN1228067 C CN 1228067C
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China
Prior art keywords
radix
acanthopanacis senticosi
caulis acanthopanacis
manufacture method
medicine
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CN 02144848
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CN1415363A (en
Inventor
韩振远
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DUODUO PHARMACEUTICAL CO LTD
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CHENXING MEDICAL INDUSTRY Co Ltd JIAMUSI HEILONGJIANG PROV
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Abstract

The present invention relates to an acanthopanax biochemistry medicine and a making method thereof, which is prepared from the following raw materials according to the proportion by weight: 18 to 26 of acanthopanax extracturm, 23 to 35 of angelica, 14 to 22 of hemlock parsley, 11 to 17 of peach seed, 7 to 11 of dried ginger and 7 to 11 of glycyrrhiza. In the method, raw materials are weighed according to the weight ratio; the hemlock parsley is put at a low temperature, dried and pulverized; the angelica, the peach seed, the glycyrrhiza and the dried ginger are decocted for 1 to 3 times, and the decoction liquids are merged and concentrated into a paste; the hemlock parsley powder and the acanthopanax extracturm are added in the paste, uniformly mixed and pulverized after being decompressed and dried, and the medicine is prepared. The present invention solves the problems of inconspicuous therapeutic effect, long administration time and large side effect existing in the present Chinese traditional medicines for treating gynecological diseases. The making method of the medicine has the characteristics of simple manufacturing process and low cost.

Description

A kind of manufacture method of slender acanthopanax biochemicals
Technical field: the present invention relates to a kind of manufacture method of medicine, particularly a kind of manufacture method that contains the medicine of Radix Et Caulis Acanthopanacis Senticosi active ingredient.
Background technology: acanthopanax root health product in the market are more, but Shang Weijian is the medicine that primary raw material is made with the Radix Et Caulis Acanthopanacis Senticosi.At present there is the shortcoming that curative effect is not obvious, administration time is long, side effect is big in the Chinese medicine of some treatment gynaecopathias, and the manufacture method of these medicines exists complex technical process, shortcoming that production cost is high again.
Summary of the invention: the present invention exists problems such as curative effect is not obvious, administration time is long, side effect is big to develop its manufacture method of a kind of slender acanthopanax biochemical agent for solving the gynopathic Chinese medicine of present treatment, and the manufacture method of this medicine has the advantages that technology is simple, cost is low.The biochemical medicine of slender acanthopanax of the present invention is made up of following raw materials by weight percent: Radix Et Caulis Acanthopanacis Senticosi extractum 18~26, Radix Angelicae Sinensis 23~35, Rhizoma Chuanxiong 14~22, Semen Persicae 11~17, Rhizoma Zingiberis 7~11, Radix Glycyrrhizae 7~11.The manufacture method of the biochemical medicine of slender acanthopanax of the present invention is carried out as follows: 1, take by weighing raw material by following percentage by weight: Radix Et Caulis Acanthopanacis Senticosi extractum 18~26, Radix Angelicae Sinensis 23~35, Rhizoma Chuanxiong 14~22, Semen Persicae 11~17, Rhizoma Zingiberis 7~11, Radix Glycyrrhizae 7~11.2, Rhizoma Chuanxiong is placed on 5 ℃~80 ℃ the following drying of low temperature, water content is reduced to below 10%, be ground into fine powder then, and seal standby; 3, Radix Angelicae Sinensis, Semen Persicae, Radix Glycyrrhizae, Rhizoma Zingiberis are decocted 1~3 time, each water that adds 2~4 times of raw material weights that decocts, decocted 1~2.5 hour, gradation filters, merge filtered solution, filtrate is concentrated into the clear paste that relative density is 1.24~1.30 (70 ℃ of surveys): 4, add Rhizoma Chuanxiong power and Radix Et Caulis Acanthopanacis Senticosi extractum in clear paste, fully mix homogeneously is pulverized behind the drying under reduced pressure and is promptly made finished product.The biochemical medicine of slender acanthopanax of the present invention is aided with five kinds of Chinese crude drug prescriptions with the monarch drug Radix Et Caulis Acanthopanacis Senticosi and forms; Radix Et Caulis Acanthopanacis Senticosi has the effect of replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; also have than better " adaptation source " effect of Radix Ginseng; can make body be in " strengthening the nonspecific defense capability state "; enhancing body is to the resistivity of destructive stimulus factor; and have the adjusting pathological process, make it be tending towards the effect of normalization.Other drug has and nourishes blood and the merit of blood, promoting tissue regeneration by removing blood stasis, is fetal abortion, puerperal, the abortion prescription commonly used of curing family's highs praise, make artificial abortion after, premature labor, induced labor, cut open the body state of lacking of proper care that the pessimal stimulation in palace product, dysmenorrhea, puerperal causes and be restored as early as possible.The Radix Angelicae Sinensis of compatibility, Rhizoma Chuanxiong etc. reach the purpose of setting upright blood stasis dispelling.The biochemical medicine function of this slender acanthopanax with cure mainly: benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, be applicable to that menstrual period and artificial abortion's postoperative, puerperal, blood stasis due to qi deficiency institute bled to vagina, color is purple dark or clot arranged, lower abdomen pain by do not subtract, aching pain in waist and back, spontaneous perspiration, shortness of breath and palpitation, light red tongue, doublely see petechia, deep and weak pulse etc.Manufacture method of the present invention has the advantage that technical process is simple, cost is low.
The specific embodiment one: the biochemical medicine of the slender acanthopanax of present embodiment is made up of following raw materials by weight percent: Radix Et Caulis Acanthopanacis Senticosi extractum 19~21, Radix Angelicae Sinensis 29~34, Rhizoma Chuanxiong 15~17, Semen Persicae 14~16, Rhizoma Zingiberis 8~9, Radix Glycyrrhizae 9~10.Its manufacture method is: 1, take by weighing raw material by above percentage by weight; 2, Rhizoma Chuanxiong is placed on 60 ℃ the following drying of low temperature, water content is reduced to below 10%, be ground into 100~150 purpose fine powders then, and seal standby; 3, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae are decocted 2 times, the decocting that adds for the first time 3.5 times of raw material weights boiled 2 hours, the decocting that adds for the second time 2.5 times of raw material weights boiled 1.5 hours, gradation filters after each the decoction, merge filtered solution then, filtrate is concentrated into the clear paste that relative density is 1.30 (70 ℃ of surveys); 4, add Rhizoma Chuanxiong power and Radix Et Caulis Acanthopanacis Senticosi extractum in clear paste, fully mix homogeneously is pulverized behind the drying under reduced pressure, and crosses sieve No. 6, makes capsule, the heavy 0.4g of every capsules.The manufacture method of above-mentioned Radix Et Caulis Acanthopanacis Senticosi extractum is: get the branch 900~1100g of Radix Et Caulis Acanthopanacis Senticosi, and pulverize, add the ethanol of 6~8 times of weight then, used concentration of ethanol is 70~80%, and continuous backflow was extracted 12 hours, filters, filtrate recycling ethanol, remaining liq is condensed into extractum, promptly.
The specific embodiment two: the biochemical medicine of the slender acanthopanax of present embodiment is made up of following raw materials by weight percent: Radix Et Caulis Acanthopanacis Senticosi extractum 22~25, Radix Angelicae Sinensis 24~28, Rhizoma Chuanxiong 18~21, Semen Persicae 12~13, Rhizoma Zingiberis 10~10.5, Radix Glycyrrhizae 8~8.5.Its manufacture method is identical with the specific embodiment one.
With the age 18~46 years old artificial abortion's postoperative, puerperal, premature labor, induced labor, cut open that is produced from the palace, the patient of blood stasis due to qi deficiency is divided into three groups due to the dysmenorrhea: A organizes each 6 of the biochemical capsule of oral slender acanthopanax, and every day 2 times: B organizes the each 10g of oral Herba Leonuri ball, obeys every day 2 times; Each 6 of C group oral placebo capsule is obeyed 2 every day; Be three days the course of treatment, it the results are shown in following table:
Table one: the overall state of an illness and efficacy result table
The state of an illness The example number Cure Produce effects Effectively Invalid Effective percentage % Obvious effective rate %
The A group Overlap meter in light 27 39 34 100 16 17 8 41 6 11 17 34 5 10 8 23 1 1 2 100 97.44 97.06 98.00 81.48 71.79 73.53 75.00
The B group Overlap meter in light 15 25 10 50 2 2 4 1 1 6 8 15 7 30 1 9 2 12 93.33 64.00 80.00 76.00 40.00 4.00 10.00 16.00
The C group Overlap meter in light 24 47 29 100 4 6 1 11 20 41 28 89 16.67 12.77 3.45 11.00 0.00 0.00 0.00 0.00
Table two: general curative effect contrast table
The example number Effective percentage % Obvious effective rate %
The A group 100 98.00 75.00
The B group 50 76.00 16.00
The C group 100 11.00 0
Table three: colporrhagia symptom Comparison of therapeutic table
The degree of bleeding The example number Cure Take a turn for the better Invalid Effective percentage %
The A group The few total in many 21 22 37 80 18 14 32 54 11 8 5 24 2 2 90.48 100 100 97.50
The B group The few total in many 6 9 30 45 2 9 11 4 4 17 25 2 3 4 9 66.67 66.67 86.67 80.00
The C group The few total in many 10 31 43 84 1 1 2 4 5 9 9 27 37 73 9.09 12.90 13.95 13.10
Table four: stomachache Comparison of therapeutic table
The stomachache degree The example number Cure Take a turn for the better Invalid Effective percentage %
The A group Moderate slightly adds up to 23 66 89 8 51 59 15 15 30 100 100 100
The B group Moderate slightly adds up to 8 29 37 6 6 6 19 25 2 4 6 75.00 86.21 83.78
The C group Moderate slightly adds up to 14 55 69 3 8 11 11 47 58 21.43 14.55 15.94
Table five: the weak and general symptom Comparison of therapeutic table in the whole body
Grouping Symptom Cure Take a turn for the better Invalid Effective percentage %
The A group 112 64 40 8 92.86
The B group 53 5 18 30 43.40
The C group 122 20 102 16.39
Table six: aching pain in waist and back Comparison of therapeutic table
Grouping The example number Cure Take a turn for the better Invalid Effective percentage %
The A group 50 37 12 1 98.00
The B group 20 2 6 12 40.00
The C group 56 6 50 10.71

Claims (2)

1. the manufacture method of a slender acanthopanax biochemicals is characterized in that, it is to carry out as follows:
1) takes by weighing raw material by following percentage by weight: Radix Et Caulis Acanthopanacis Senticosi extractum 19~21, Radix Angelicae Sinensis 29~34, Rhizoma Chuanxiong 15~17, Semen Persicae 14~16, Rhizoma Zingiberis 8~9, Radix Glycyrrhizae 9~10 or Radix Et Caulis Acanthopanacis Senticosi extractum 22~25, Radix Angelicae Sinensis 24~28, Rhizoma Chuanxiong 18~21, Semen Persicae 12~13, Rhizoma Zingiberis 10~10.5, Radix Glycyrrhizae 8~8.5;
2) low temperature that Rhizoma Chuanxiong is placed on 5 ℃~80 ℃ descends drying, and its water content is reduced to below 10%, is ground into fine powder then, and seals standby;
3) Radix Angelicae Sinensis, Semen Persicae, Radix Glycyrrhizae, Rhizoma Zingiberis are decocted 1~3 time, each water that adds 2~4 times of raw material weights that decocts decocted 1~2.5 hour, and gradation filters, the merging filtered solution, and it is 1.24~1.30 clear paste that filtrate is concentrated into relative density, 70 ℃ of measurements;
4) add Rhizoma Chuanxiong power and Radix Et Caulis Acanthopanacis Senticosi extractum in clear paste, fully mix homogeneously is pulverized behind the drying under reduced pressure and is promptly made finished product.
2. according to the manufacture method of a kind of slender acanthopanax biochemicals of claim 1, it is characterized in that, the manufacture method of above-mentioned Radix Et Caulis Acanthopanacis Senticosi extractum is: the branch 900~1100g that gets Radix Et Caulis Acanthopanacis Senticosi, and pulverize, adding the ethanol of 6~8 times of weight then, used concentration of ethanol is 70%~80%, continuous backflow was extracted 12 hours, filter, filtrate recycling ethanol, remaining liq is condensed into extractum.
CN 02144848 2002-11-14 2002-11-14 Biochemical medicament of araliaceae plant and its preparation method Expired - Lifetime CN1228067C (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102366621B (en) * 2011-09-30 2013-01-30 多多药业有限公司 Plant estrogenic effect of acanthopanax biochemical traditional Chinese medicine compound extract and its application
CN104474217A (en) * 2014-10-29 2015-04-01 济南方宇文化传媒有限公司 Traditional Chinese medicine preparation for improving neuralgic amyotrophy and preparation method thereof
CN112773883A (en) * 2020-12-31 2021-05-11 多多药业有限公司 Preparation method of acanthopanax biochemical capsule containing ingredients capable of inhibiting dysmenorrhea

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