A kind of manufacture method of slender acanthopanax biochemicals
Technical field: the present invention relates to a kind of manufacture method of medicine, particularly a kind of manufacture method that contains the medicine of Radix Et Caulis Acanthopanacis Senticosi active ingredient.
Background technology: acanthopanax root health product in the market are more, but Shang Weijian is the medicine that primary raw material is made with the Radix Et Caulis Acanthopanacis Senticosi.At present there is the shortcoming that curative effect is not obvious, administration time is long, side effect is big in the Chinese medicine of some treatment gynaecopathias, and the manufacture method of these medicines exists complex technical process, shortcoming that production cost is high again.
Summary of the invention: the present invention exists problems such as curative effect is not obvious, administration time is long, side effect is big to develop its manufacture method of a kind of slender acanthopanax biochemical agent for solving the gynopathic Chinese medicine of present treatment, and the manufacture method of this medicine has the advantages that technology is simple, cost is low.The biochemical medicine of slender acanthopanax of the present invention is made up of following raw materials by weight percent: Radix Et Caulis Acanthopanacis Senticosi extractum 18~26, Radix Angelicae Sinensis 23~35, Rhizoma Chuanxiong 14~22, Semen Persicae 11~17, Rhizoma Zingiberis 7~11, Radix Glycyrrhizae 7~11.The manufacture method of the biochemical medicine of slender acanthopanax of the present invention is carried out as follows: 1, take by weighing raw material by following percentage by weight: Radix Et Caulis Acanthopanacis Senticosi extractum 18~26, Radix Angelicae Sinensis 23~35, Rhizoma Chuanxiong 14~22, Semen Persicae 11~17, Rhizoma Zingiberis 7~11, Radix Glycyrrhizae 7~11.2, Rhizoma Chuanxiong is placed on 5 ℃~80 ℃ the following drying of low temperature, water content is reduced to below 10%, be ground into fine powder then, and seal standby; 3, Radix Angelicae Sinensis, Semen Persicae, Radix Glycyrrhizae, Rhizoma Zingiberis are decocted 1~3 time, each water that adds 2~4 times of raw material weights that decocts, decocted 1~2.5 hour, gradation filters, merge filtered solution, filtrate is concentrated into the clear paste that relative density is 1.24~1.30 (70 ℃ of surveys): 4, add Rhizoma Chuanxiong power and Radix Et Caulis Acanthopanacis Senticosi extractum in clear paste, fully mix homogeneously is pulverized behind the drying under reduced pressure and is promptly made finished product.The biochemical medicine of slender acanthopanax of the present invention is aided with five kinds of Chinese crude drug prescriptions with the monarch drug Radix Et Caulis Acanthopanacis Senticosi and forms; Radix Et Caulis Acanthopanacis Senticosi has the effect of replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; also have than better " adaptation source " effect of Radix Ginseng; can make body be in " strengthening the nonspecific defense capability state "; enhancing body is to the resistivity of destructive stimulus factor; and have the adjusting pathological process, make it be tending towards the effect of normalization.Other drug has and nourishes blood and the merit of blood, promoting tissue regeneration by removing blood stasis, is fetal abortion, puerperal, the abortion prescription commonly used of curing family's highs praise, make artificial abortion after, premature labor, induced labor, cut open the body state of lacking of proper care that the pessimal stimulation in palace product, dysmenorrhea, puerperal causes and be restored as early as possible.The Radix Angelicae Sinensis of compatibility, Rhizoma Chuanxiong etc. reach the purpose of setting upright blood stasis dispelling.The biochemical medicine function of this slender acanthopanax with cure mainly: benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, be applicable to that menstrual period and artificial abortion's postoperative, puerperal, blood stasis due to qi deficiency institute bled to vagina, color is purple dark or clot arranged, lower abdomen pain by do not subtract, aching pain in waist and back, spontaneous perspiration, shortness of breath and palpitation, light red tongue, doublely see petechia, deep and weak pulse etc.Manufacture method of the present invention has the advantage that technical process is simple, cost is low.
The specific embodiment one: the biochemical medicine of the slender acanthopanax of present embodiment is made up of following raw materials by weight percent: Radix Et Caulis Acanthopanacis Senticosi extractum 19~21, Radix Angelicae Sinensis 29~34, Rhizoma Chuanxiong 15~17, Semen Persicae 14~16, Rhizoma Zingiberis 8~9, Radix Glycyrrhizae 9~10.Its manufacture method is: 1, take by weighing raw material by above percentage by weight; 2, Rhizoma Chuanxiong is placed on 60 ℃ the following drying of low temperature, water content is reduced to below 10%, be ground into 100~150 purpose fine powders then, and seal standby; 3, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae are decocted 2 times, the decocting that adds for the first time 3.5 times of raw material weights boiled 2 hours, the decocting that adds for the second time 2.5 times of raw material weights boiled 1.5 hours, gradation filters after each the decoction, merge filtered solution then, filtrate is concentrated into the clear paste that relative density is 1.30 (70 ℃ of surveys); 4, add Rhizoma Chuanxiong power and Radix Et Caulis Acanthopanacis Senticosi extractum in clear paste, fully mix homogeneously is pulverized behind the drying under reduced pressure, and crosses sieve No. 6, makes capsule, the heavy 0.4g of every capsules.The manufacture method of above-mentioned Radix Et Caulis Acanthopanacis Senticosi extractum is: get the branch 900~1100g of Radix Et Caulis Acanthopanacis Senticosi, and pulverize, add the ethanol of 6~8 times of weight then, used concentration of ethanol is 70~80%, and continuous backflow was extracted 12 hours, filters, filtrate recycling ethanol, remaining liq is condensed into extractum, promptly.
The specific embodiment two: the biochemical medicine of the slender acanthopanax of present embodiment is made up of following raw materials by weight percent: Radix Et Caulis Acanthopanacis Senticosi extractum 22~25, Radix Angelicae Sinensis 24~28, Rhizoma Chuanxiong 18~21, Semen Persicae 12~13, Rhizoma Zingiberis 10~10.5, Radix Glycyrrhizae 8~8.5.Its manufacture method is identical with the specific embodiment one.
With the age 18~46 years old artificial abortion's postoperative, puerperal, premature labor, induced labor, cut open that is produced from the palace, the patient of blood stasis due to qi deficiency is divided into three groups due to the dysmenorrhea: A organizes each 6 of the biochemical capsule of oral slender acanthopanax, and every day 2 times: B organizes the each 10g of oral Herba Leonuri ball, obeys every day 2 times; Each 6 of C group oral placebo capsule is obeyed 2 every day; Be three days the course of treatment, it the results are shown in following table:
Table one: the overall state of an illness and efficacy result table
| The state of an illness | The example number | Cure | Produce effects | Effectively | Invalid | Effective percentage % | Obvious effective rate % |
The A group | Overlap meter in light | 27 39 34 100 | 16 17 8 41 | 6 11 17 34 | 5 10 8 23 | 1 1 2 | 100 97.44 97.06 98.00 | 81.48 71.79 73.53 75.00 |
The B group | Overlap meter in light | 15 25 10 50 | 2 2 | 4 1 1 6 | 8 15 7 30 | 1 9 2 12 | 93.33 64.00 80.00 76.00 | 40.00 4.00 10.00 16.00 |
The C group | Overlap meter in light | 24 47 29 100 | | | 4 6 1 11 | 20 41 28 89 | 16.67 12.77 3.45 11.00 | 0.00 0.00 0.00 0.00 |
Table two: general curative effect contrast table
| The example number | Effective percentage % | Obvious effective rate % |
The A group | 100 | 98.00 | 75.00 |
The B group | 50 | 76.00 | 16.00 |
The C group | 100 | 11.00 | 0 |
Table three: colporrhagia symptom Comparison of therapeutic table
| The degree of bleeding | The example number | Cure | Take a turn for the better | Invalid | Effective percentage % |
The A group | The few total in many | 21 22 37 80 | 18 14 32 54 | 11 8 5 24 | 2 2 | 90.48 100 100 97.50 |
The B group | The few total in many | 6 9 30 45 | 2 9 11 | 4 4 17 25 | 2 3 4 9 | 66.67 66.67 86.67 80.00 |
The C group | The few total in many | 10 31 43 84 | 1 1 2 | 4 5 9 | 9 27 37 73 | 9.09 12.90 13.95 13.10 |
Table four: stomachache Comparison of therapeutic table
| The stomachache degree | The example number | Cure | Take a turn for the better | Invalid | Effective percentage % |
The A group | Moderate slightly adds up to | 23 66 89 | 8 51 59 | 15 15 30 | | 100 100 100 |
The B group | Moderate slightly adds up to | 8 29 37 | 6 6 | 6 19 25 | 2 4 6 | 75.00 86.21 83.78 |
The C group | Moderate slightly adds up to | 14 55 69 | | 3 8 11 | 11 47 58 | 21.43 14.55 15.94 |
Table five: the weak and general symptom Comparison of therapeutic table in the whole body
Grouping | Symptom | Cure | Take a turn for the better | Invalid | Effective percentage % |
The A group | 112 | 64 | 40 | 8 | 92.86 |
The B group | 53 | 5 | 18 | 30 | 43.40 |
The C group | 122 | | 20 | 102 | 16.39 |
Table six: aching pain in waist and back Comparison of therapeutic table
Grouping | The example number | Cure | Take a turn for the better | Invalid | Effective percentage % |
The A group | 50 | 37 | 12 | 1 | 98.00 |
The B group | 20 | 2 | 6 | 12 | 40.00 |
The C group | 56 | | 6 | 50 | 10.71 |