CN119564521A - A cleaning composition containing chloroxylenol and its use - Google Patents

Abstract

The invention belongs to the field of daily chemicals, and discloses a cleaning composition containing chloroxylenol, which is a water system surface active system, wherein the water system surface active system contains chloroxylenol and sodium lauryl sulfate, and the water system surface active system contains 1-6.5wt% of sodium lauryl sulfate. The composition contains chloroxylenol and sodium lauryl sulfate, and the chloroxylenol and sodium lauryl sulfate are synergistically combined to achieve a good sterilization effect. Meanwhile, the invention also discloses application of the composition.

Description

Cleaning composition containing chloroxylenol and application thereof

Technical Field

The invention relates to the field of daily chemicals, in particular to a chloroxylenol-containing cleaning composition and application thereof.

Background

The bactericides used in the washing products in the market at present are mostly triclosan, triclocarban, piroctone olamine salt, sodium hypochlorite and the like, and according to the literature, the triclosan and the triclocarban possibly have reproductive genetic toxicity to organisms and have a certain risk, the piroctone olamine salt has no reproductive genetic toxicity, but is easy to oxidize and lose efficacy, chloroxylenol and a surfactant are matched to wrap and inhibit bacteria and lose efficacy, and sodium hypochlorite bleaching components have strong oxidization, strong alkalinity and strong corrosiveness.

Chloroxylenol is a phenolic bacteriostatic agent, is widely applied to disinfectant fluid, and has mild and high safety to skin. However, chloroxylenol is used as a traditional phenolic bacteriostatic agent, and is not widely applied to washing products at present, because the chloroxylenol bacteriostatic agent and the surfactant have poor compatibility, and the bacteriostatic activity is easily reduced by the surfactant, so that the bacteriostasis is invalid.

The literature on chloroxylenol in a cleaning article can be referred to as follows:

CN117815157A, a skin care composition, a preparation method, a skin care product and application, chloroxylenol is used as a preservative;

CN117643554a, a low-irritation high-foaming skin cleaning composition and a preparation method thereof, chloroxylenol is used as a preservative;

CN112075432A, a nicotinamide composite bactericide, a preparation method and application thereof, and chloroxylenol and nicotinamide are used as composite bactericides.

In the prior art, no proposal is focused on the problem that chloroxylenol is easy to lose efficacy in surface activity, and no related technology is used for solving the problem of how to further resist bacteria and increase efficiency in a surface activity system.

Therefore, the technical problem solved by the scheme is how to fully exert or enhance the antibacterial performance of chloroxylenol in a surface active system.

Disclosure of Invention

The invention aims to provide a cleaning composition containing chloroxylenol, which contains chloroxylenol and sodium lauryl sulfate, and the two components are synergistically combined to achieve a good sterilization effect.

Meanwhile, the invention also discloses application of the composition.

In order to achieve the above purpose, the present invention provides the following technical solutions:

a cleaning composition containing chloroxylenol comprises a water system surface active system, wherein the water system surface active system contains chloroxylenol and sodium lauryl sulfate, the water system surface active system contains 1-6.5wt% of sodium lauryl sulfate, and preferably, the water system surface active system contains 1-4wt% of sodium lauryl sulfate.

Sodium lauryl sulfate is not only a relatively common anion, but is reported in a small number of documents to have slight antibacterial and no antibacterial abilities. The conclusions of the relevant literature were further verified in the study of the present invention.

The invention adopts sodium lauryl sulfate and chloroxylenol to combine and use, can improve the bacteriostasis rate of the escherichia coli ATCC 25922 from 45% to more than 95% within 2min, and improve the bacteriostasis rate of the staphylococcus aureus ATCC 6538 to more than 99.9%.

The related mechanism is not clear, but experiments prove that when other anions are used in combination with chloroxylenol, the antibacterial capacity of the chloroxylenol cannot be improved, so that the obvious improvement of the antibacterial capacity of the chloroxylenol is considered to have no direct correlation with the use of the anions, the antibacterial channel with the slight antibacterial capacity of sodium lauryl sulfate is considered to have a certain relationship with the slight antibacterial capacity of sodium lauryl sulfate, but the antibacterial channel with the slight antibacterial capacity of sodium lauryl sulfate is not clear, and the phenomenon of synergistic enhancement cannot be further explained.

In the cleaning composition, the water-based surfactant system further comprises one or two of potassium cocoyl glycinate, acrylic acid (ester) and stearyl alcohol polyether-20 methacrylate copolymer AG-U8.

The cocoyl glycine potassium is an anionic surfactant, no literature reports that the cocoyl glycine potassium has antibacterial capability, and when the cocoyl glycine potassium is added into the emulsifying system disclosed by the invention, the antibacterial rate of escherichia coli of sodium lauryl sulfate and chloroxylenol can be improved from 98.5% to 99.9%, so that thorough antibacterial effect is realized;

The functional verification of sodium lauryl sulfate and potassium cocoyl glycinate shows that if other anions are adopted to replace sodium lauryl sulfate, the antibacterial capability of chloroxylenol cannot be obviously improved; in the presence of sodium lauryl sulfate, the antibacterial ability of chloroxylenol can be further improved by preferentially selecting other anions for surface activity;

thus, it can be concluded here that the improvement in the antibacterial ability of chloroxylenol is closely related to the presence of sodium lauryl sulfate, on the basis of which it is preferable that the other anionic surfactants can continue to improve the antibacterial ability of chloroxylenol to some extent;

the acrylic acid (ester)/stearyl alcohol polyether-20 methacrylate copolymer AG-U8 is a surfactant and a thickener, and has at least three functions in the system of the invention, namely thickening, system stability enhancement under low temperature and bacteriostasis enhancement;

After the acrylic acid (ester)/stearyl alcohol polyether-20 methacrylate copolymer AG-U8 is used in the system, the antibacterial capacity of the system is improved from 95% to 99.9% from the antibacterial rate of escherichia coli, and thorough antibacterial effect is realized.

In summary, in the presence of sodium lauryl sulfate, the anionic surfactant is preferable, and the thickener for improving the system at a normal low temperature is preferable, so that the antibacterial capability of chloroxylenol can be remarkably improved.

In the above cleaning composition, the aqueous surfactant system contains 0 to 4wt% of potassium cocoyl glycinate, preferably 0.5 to 4wt% of potassium cocoyl glycinate.

In the cleaning composition, the aqueous surfactant system contains 0-4wt% of acrylic acid (ester) based/stearyl alcohol polyether-20 methacrylate copolymer AG-U8, preferably 1-4wt% of acrylic acid (ester) based/stearyl alcohol polyether-20 methacrylate copolymer AG-U8.

In the cleaning composition, the water-based surfactant system comprises a surfactant and water, wherein the surfactant is one or a combination of more of an anionic surfactant, a zwitterionic surfactant and a nonionic surfactant.

The cleaning composition of claim 5, wherein the anionic surfactant is one or more of sodium laureth sulfate, sodium C8-C18 polyether sulfate, sodium trideceth sulfate;

the amphoteric surfactant is one or a combination of more of cocamidopropyl betaine, C8-C18 alkyl betaine, C8-C18 amidohydroxysulfobetaine and C8-C18 alkyl hydroxysulfobetaine;

The nonionic surfactant is one or more of cocamide DEA, cocamide MEA and cocamide methyl MEA, and the water-based surfactant system further comprises one or more of essence, preservative, chelating agent, humectant and sodium chloride.

More specifically, the system of the present invention contains the following components:

1-4wt% of acrylic acid (ester)/stearyl alcohol polyether-20 methacrylate copolymer;

1-4wt% of sodium lauryl sulfate;

11-18wt% of sodium laureth sulfate;

2-6wt% of cocamidopropyl amine propyl betaine;

0.2-0.3wt% of chloroxylenol;

0.5-4wt% of potassium cocoyl glycinate;

A proper amount of chelating agent, propylene glycol, pH regulator, preservative, essence, sodium chloride and other auxiliary agents;

The balance of water was added to 100%.

Meanwhile, the invention also discloses application of the cleaning composition in preparing a cleaning type washing and caring cosmetic.

In the above application, the cleansing cosmetic is a hand cleanser, a body wash or a shampoo.

Compared with the prior art, the invention has the beneficial effects that:

the invention adopts the synergistic combination of chloroxylenol and sodium laurylsulfate, and can play a good role in sterilization.

Detailed Description

The technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

The relevant original sources of the invention are described as follows:

disodium EDTA: vendor, akunobeol;

sodium laureth sulfate (RSAW ESB 70/ZA) suppliers of Guangdong Lichen Aowei Utility Co., ltd;

sodium lauryl sulfate (LXNS/ZA) suppliers of Guangdong Lichen Aowei Utility Co., ltd;

Cocamidopropyl amine propyl betaine (CAB-35) supplier, guangzhou Star technologies Co., ltd;

chloroxylenol (PCMX) vendor, guangdimei biotechnology limited;

potassium cocoyl glycinate YCK-30K, supplier: nanjing lion New Material Co., ltd;

Acrylic acid (esters) copolymer AG-U8 of stearyl alcohol polyether-20 methacrylate ester, supplier: green extract source biotechnology Co., ltd. In Buddha;

Benzalkonium chloride suppliers, guangdong coconut real Co., ltd

Kathon, supplier, guangdong Dimei Biotechnology Co.

Diaminopropyl dodecylamine: suppliers Ningbo Xiangshen Biochemical Co., ltd

Hand antibacterial cleaning composition containing chloroxylenol in first part

The preparation process comprises the following steps:

Pretreatment, namely heating and dissolving PCMX and propylene glycol;

1. Adding EDTA disodium and AG-U8 and LXNS/ZA into water, stirring, dispersing and dissolving, adding sodium hydroxide, stirring and dissolving;

2. adding RSAW ESB70/ZA and CAB-35 into the mixture, stirring the mixture to dissolve, adding pretreated bacteriostatic agent and YCK-30K into the mixture, stirring the mixture to dissolve;

3. Adding antiseptic and essence, stirring and dissolving;

4. the pH and viscosity were adjusted.

The test formulations are specified in table 1 below;

TABLE 1 formulation table unit g

Performance test:

The test items include:

stability, test for 7 weeks with reference to GB/T34855 method;

The antibacterial rate at normal temperature is shown by referring to QB/T2738, E.coli ATCC 25922 and staphylococcus aureus ATCC 6538, and the action time is 2 minutes.

The test results can be referred to in table 2 below;

table 2 test results

From the above test results, the following conclusions can be drawn:

1. As can be seen from comparative example 2, the antibacterial effect of the system is poor in the absence of chloroxylenol, which indicates that sodium lauryl sulfate in the system can only exert a weak antibacterial effect, and is consistent with the conclusion reported in the literature.

2. The comparison example 1 shows that under the condition of missing sodium lauryl sulfate, the antibacterial effect on escherichia coli ATCC 25922 is reduced to below 50%, so that the sodium lauryl sulfate can effectively improve the antibacterial performance of chloroxylenol, and the antibacterial synergistic effect is proved.

3. It can be seen from examples 1 to 4 and examples 5 and 6 that potassium cocoyl glycinate, acrylic acid (esters) and steareth-20 methacrylate copolymer AG-U8 have a correlation with the temperature stability of the system, and that both can at least increase the bacteriostatic effect of chloroxylenol when it is exposed to E.coli by one order of magnitude.

4. As can be seen from examples 1-5 and example 6, the acrylic/steareth-20 methacrylate copolymer AG-U8 is a critical factor in achieving low temperature stability.

5. It is apparent from comparative examples 3 and 4 that the antibacterial effect of the present invention cannot be achieved by using other surfactants having similar or even better antibacterial effects, because the above synergistic mechanism may not exist, and the stability of the system may be inferior to the antibacterial effect caused by the present invention.

Meanwhile, during the research process of the invention, it is found that the following emulsifying agents are not recommended to be added into an emulsifying system, and the emulsifying agents can damage the antibacterial activity of chloroxylenol and lead the chloroxylenol to be in antibacterial failure, and the specific emulsifying agents are laureth-7, laureth-9, C12-15 alkanol polyether-7 and C12-15 alkanol polyether-9.

Second part safety test

The cosmetic safety test was changed to one complete skin irritation test for examples 1-5, the test method was 2002 edition of sterilizing technical Specification, second section 2.3.3

The test results are shown in Table 3;

TABLE 3 results of the irritation test

Third part other application formulations

The present invention is not limited to the formulation described in the first part of table 1, and the aqueous surfactant system of the present invention may be implemented in many more ways, as shown in the following table 4;

table 4 formulation table

Claims (10)

1. A cleaning composition containing chloroxylenol, characterized in that the cleaning composition is an aqueous surfactant system, the aqueous surfactant system contains chloroxylenol and sodium lauryl sulfate; the aqueous surfactant system contains 1 to 6.5 wt% of sodium lauryl sulfate. 2. The cleaning composition according to claim 1, characterized in that the aqueous surfactant system further contains one or a combination of two of potassium cocoyl glycinate and acrylic acid (esters)/stearyl alcohol polyether-20 methacrylate copolymer AG-U8. 3. The cleaning composition according to claim 2, characterized in that the aqueous surfactant system contains 0.5 to 4 wt% of potassium cocoyl glycinate; the aqueous surfactant system contains 1 to 4 wt% of acrylic acid (esters)/stearyl alcohol polyether-20 methacrylate copolymer AG-U8. 4. The cleaning composition according to claim 1, wherein the aqueous surfactant system contains 1 to 4 wt% of sodium lauryl sulfate. 5. The cleaning composition according to claim 1, characterized in that the aqueous surfactant system comprises a surfactant and water; the surfactant is a combination of one or more of anionic surfactants, zwitterionic surfactants, and nonionic surfactants. 6. The cleaning composition according to claim 5, characterized in that the anionic surfactant is one or more combinations of sodium laureth sulfate, sodium C8-C18 polyether sulfate, and sodium tridecyl alcohol polyether sulfate; The zwitterionic surfactant is one or more combinations of cocamidopropyl betaine, C8-C18 alkyl betaine, C8-C18 amide hydroxysulfonate, and C8-C18 alkyl hydroxysulfonate; The nonionic surfactant is one or more combinations of cocamide DEA, cocamide MEA, and cocamide methyl MEA. 7. The cleaning composition according to claim 1, characterized in that the aqueous surfactant system further comprises one or more combinations of fragrance, preservative, chelating agent, humectant, and sodium chloride. 8. The cleaning composition according to claims 1 to 7, characterized in that the aqueous surfactant system contains 0.2 to 0.3 wt% of chloroxylenol. 9. Use of the cleaning composition according to any one of claims 1 to 8 in preparing cleansing cosmetics. 10. The use according to claim 9, characterized in that the cleansing cosmetic product is hand soap, shower gel or shampoo.