CN113244129A - Antibacterial hand sanitizer and preparation method thereof - Google Patents
Antibacterial hand sanitizer and preparation method thereof Download PDFInfo
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Abstract
The invention provides an antibacterial hand sanitizer which comprises the following raw material components in percentage by weight: 1-10% of alkyl glycoside; 5-20% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-10% of lauramidopropyl betaine; 1-10% of a humectant; 0.05 to 0.9 percent of preservative; 0.1 to 0.5 percent of essence; 0.2 to 1 percent of bacteriostatic agent; citric acid monohydrate 0-1%; 0-1% of sodium hydroxide; 0.05 to 0.2 percent of auxiliary agent; water to 100%; the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol, or the bacteriostatic agent is a mixture of lactic acid and piroctone olamine; according to the antibacterial hand sanitizer, the antibacterial agent is compatible with the alkyl glycoside, the fatty alcohol-polyoxyethylene ether sodium sulfate, the lauramidopropyl betaine and other components, and the synergistic effect is achieved, so that the synergistic antibacterial effect can be achieved, and the antibacterial capability of the hand sanitizer is remarkably enhanced; the system is endowed with higher stability, and the production, packaging and transportation costs can be reduced; the preparation method is simple, the process is mature, and the solid can be dissolved into a stable system under the condition of mixing and stirring at normal temperature, thereby being beneficial to popularization and application.
Description
Technical Field
The invention relates to the technical field of daily chemical products, and particularly relates to an antibacterial hand sanitizer and a preparation method thereof.
Background
Nowadays, the application of hand washing solutions is becoming more and more common in the market and in life. The hand sanitizer is a daily cleaning product, and compared with the traditional perfumed soap and soap, the hand sanitizer avoids the defect that solid matters are easy to contaminate dirt and bacteria on hands, reduces the possibility of cross infection, and is more easily accepted by consumers. The hand sanitizer is divided into a common hand sanitizer and an antibacterial hand sanitizer. The bacteriostatic hand sanitizer is favored by consumers due to the bacteriostatic function.
Common bacteriostatic agents in the current hand sanitizer comprise parachlorometaxylenol, o-cymene-5-ol, piroctone olamine salt, salicylic acid and the like. At present, cymene, parachlorometaxylenol, salicylic acid and the like are mostly adopted as bacteriostatic components in the market. However, parachlorometaxylenol is poor in water solubility and cannot sufficiently exert the bactericidal effect of the bacteriostatic active ingredient. The piroctone olamine salt is an effective antibacterial component, is relatively mild and safe, has high solubility, and can play a role in sterilization only by adding a relatively high dosage.
Therefore, providing an antibacterial hand sanitizer with excellent bactericidal effect and good stability and a preparation method thereof is one of the technical problems to be solved urgently by those skilled in the art.
Disclosure of Invention
The invention solves the problems of high addition amount of bacteriostatic agent, general bacteriostatic effect and poor stability in the bacteriostatic hand sanitizer.
In order to solve the above problems, the technical solution of the present invention is realized as follows:
the invention provides an antibacterial hand sanitizer which comprises the following raw material components in percentage by weight: 1-10% of alkyl glycoside; 5-20% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-10% of lauramidopropyl betaine; 1-10% of a humectant; 0.05 to 0.9 percent of preservative; 0.1 to 0.5 percent of essence; 0.2 to 1 percent of bacteriostatic agent; citric acid monohydrate 0-1%; 0-1% of sodium hydroxide; 0.05 to 0.2 percent of auxiliary agent and water which is complemented to 100 percent; the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol, or the bacteriostatic agent is a mixture of lactic acid and piroctone olamine. The antibacterial hand sanitizer disclosed by the invention has the advantages that the chloroxylenol or piroctone olamine salt is compatible with the lactic acid, alkyl glycoside, fatty alcohol-polyoxyethylene ether sodium sulfate, lauramidopropyl betaine and other components, and the synergistic effect is realized, so that the synergistic antibacterial effect can be achieved, and the antibacterial capability of the hand sanitizer is obviously enhanced; the system is endowed with higher stability, and the production, packaging and transportation costs can be reduced; the preparation method is simple, the process is mature, and the product can be dissolved into a stable system under the condition of mixing and stirring at normal temperature, thereby being beneficial to popularization and application.
Further, the antibacterial hand sanitizer comprises the following raw material components in percentage by weight: 1-4% of alkyl glycoside; 5-8% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-3.2% of lauramidopropyl betaine; 3.1% of a moisturizing agent; 0.08 percent of preservative; 0.3 percent of essence; 0.4 to 0.6 percent of bacteriostatic agent; 0-0.013% of sodium hydroxide; 0.05% of auxiliary agent and water which is complemented to 100%; the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol, or the bacteriostatic agent is a mixture of lactic acid and piroctone olamine.
Further, the antibacterial hand sanitizer comprises the following raw material components in percentage by weight: 2-4% of alkyl glycoside; 5-7% of fatty alcohol-polyoxyethylene ether sodium sulfate; 2-3.2% of lauramidopropyl betaine; 3.1% of a moisturizing agent; 0.08 percent of preservative; 0.3 percent of essence; 0.4 percent of bacteriostatic agent; 0.013 percent of sodium hydroxide; 0.05% of assistant; water to 100%; the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol. The lactic acid can not only adjust the pH value, but also can act synergistically with parachlorometaxylenol, so that the sterilization effect of the system is improved.
Further, the antibacterial hand sanitizer comprises the following raw material components in percentage by weight: 1-2% of alkyl glycoside; 7-8% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-3.2% of lauramidopropyl betaine; 3.1% of a moisturizing agent; 0.08 percent of preservative; 0.3 percent of essence; 0.6 percent of bacteriostatic agent; 0.05% of an auxiliary agent; water to 100%; the bacteriostatic agent is a mixture of lactic acid and piroctone olamine. Lactic acid can not only adjust pH, but also can act synergistically with piroctone olamine salt, thereby improving the sterilization effect of the system.
Further, the humectant is any one or a mixture of more than two of glycerol, propylene glycol, PEG400 and PEG-7 glyceryl cocoate. The use of the humectant can not only improve the viscosity of the hand sanitizer, but also increase the moisturizing effect of the hand sanitizer.
Further, the auxiliary agent is one or a mixture of two of ethylene diamine tetraacetic acid and sodium citrate.
Further, the preservative is any one or a mixture of more than two of sodium benzoate, phenoxyethanol, ethylhexyl glycerol, methylchloroisothiazolinone and methylisothiazolinone.
A preparation method of a bacteriostatic hand sanitizer is used for preparing any one of the bacteriostatic hand sanitizers, and comprises the following steps:
adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol-polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, bacteriostatic agent, citric acid monohydrate, sodium hydroxide, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed. The antibacterial hand sanitizer disclosed by the invention is simple in preparation method and mature in process, can be dissolved into a stable system under normal temperature mixing and stirring, and is beneficial to popularization and application.
Compared with the prior art, the antibacterial hand sanitizer disclosed by the invention has the following beneficial effects:
1) according to the antibacterial hand sanitizer, the chloroxylenol or piroctone olamine salt is compounded with the lactic acid, and the lactic acid can not only adjust the pH value, but also synergistically act with the chloroxylenol or piroctone olamine salt, so that the sterilization effect is improved.
2) According to the antibacterial hand sanitizer, the alkyl glycoside, the fatty alcohol-polyoxyethylene ether sodium sulfate, the lauramide propyl betaine and other components are compatible with each other, and have a synergistic effect, so that a cleaning effect of synergy is exerted.
3) The antibacterial hand sanitizer disclosed by the invention has the advantages that the chloroxylenol or piroctone olamine salt is compatible with the components such as lactic acid, alkyl glycoside, fatty alcohol-polyoxyethylene ether sodium sulfate and lauramidopropyl betaine, and the like, and the synergistic effect is realized, so that the system is endowed with higher stability, and the production, packaging and transportation costs can be reduced.
4) The antibacterial hand sanitizer disclosed by the invention is simple in preparation method and mature in process, can be dissolved into a stable system under normal temperature mixing and stirring, and is beneficial to popularization and application.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.
A bacteriostatic hand sanitizer is provided, wherein a surfactant is the most basic component in the formula of the hand sanitizer, and the used surfactant is required to have good wetting power, detergency, emulsifying power, foaming power and good synergistic effect. In recent years, the selection of surfactants has focused on improvement in skin protection, low irritation, no toxicity, and high biodegradability.
The surfactant selected by the application is compounded by alkyl glycoside, fatty alcohol-polyoxyethylene ether sodium sulfate and lauramide propyl betaine. The alkyl glycoside is a nonionic surfactant, has good compatibility, and can be compounded with various ionic and nonionic surfactants to generate a synergistic effect; the foaming property is good, and the foam is rich and fine; has good compatibility with skin, obviously improves the mildness of the formula, and is non-toxic, non-irritant and easily biodegradable. The sodium fatty alcohol polyoxyethylene ether sulfate is an anionic surfactant and has good compatibility with other surfactants; has emulsifying, foaming and decontaminating effects; lauramide propyl betaine is an extremely low-irritation amphoteric surfactant, can be widely compatible with cationic, anionic and nonionic surfactants, has ideal washing, conditioning, antistatic and sterilizing effects, excellent softness, mild skin action and abundant and stable foam.
The most important component in the bacteriostatic hand sanitizer is a bacteriostatic agent. The bacteriostat selected for use in the application is a mixture of lactic acid and parachlorometaxylenol, or the bacteriostat is a mixture of lactic acid and piroctone olamine.
Among them, parachlorometaxylenol is one of the most effective bacteriostatic components of the hand sanitizer, has a killing effect on most gram-negative bacteria and gram-positive bacteria, fungi and mold, is a low-toxicity antibacterial agent, but has low solubility in water and poor stability.
The piroctone olamine salt has the functions of sterilization and antioxidation, is a high-efficiency, nontoxic and nonirritating bacteriostatic agent, has good thermal stability, and can be compounded with various cationic surfactants and cationic active components.
The chloroxylenol or piroctone olamine have a common problem that a certain sterilization effect can be achieved only when the required addition amount is relatively high. When the lactic acid and the parachlorometaxylenol or the piroctone olamine salt are used simultaneously, the lactic acid not only can adjust the pH value, but also can synergistically act with the parachlorometaxylenol or the piroctone olamine salt to increase the sterilization effect.
The antibacterial hand sanitizer comprises the following raw material components in percentage by weight: 1-10% of alkyl glycoside; 5-20% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-10% of lauramidopropyl betaine; 1-10% of a humectant; 0.05 to 0.08 percent of preservative; 0.1 to 0.5 percent of essence; 0.2 to 1 percent of bacteriostatic agent; citric acid monohydrate 0-1%; 0-1% of sodium hydroxide; 0.05 to 0.2 percent of auxiliary agent; water to 100%; the bacteriostatic agent is a mixture of lactic acid and p-chloro-m-cresol, or the bacteriostatic agent is a mixture of lactic acid and piroctone olamine. The antibacterial hand sanitizer disclosed by the invention has the synergistic effect of mutually matching chloroxylenol or piroctone olamine salt with lactic acid, alkyl glycoside, sodium fatty alcohol-polyoxyethylene ether sulfate, lauramidopropyl betaine and other components, can achieve a synergistic antibacterial effect, and obviously enhances the antibacterial capability of the hand sanitizer.
Specifically, the antibacterial hand sanitizer comprises the following raw material components in percentage by weight: 1-4% of alkyl glycoside; 5-8% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.08 percent of preservative; 0.3 percent of essence; 0.4 to 0.6 percent of bacteriostatic agent; 0-0.013% of sodium hydroxide; 0.05% of assistant agent and water which is complemented to 100%; the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol, or the bacteriostatic agent is a mixture of lactic acid and piroctone olamine.
Example 1
The formula (comprising the following components in parts by weight): 2% of alkyl glycoside; 7% of fatty alcohol-polyoxyethylene ether sodium sulfate; 3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.1% of preservative; 0.3 percent of essence; 0.4 percent of bacteriostatic agent; 0.013 percent of sodium hydroxide; 0.05% of an auxiliary agent; the water is added to 100 percent.
Specifically, the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol. Wherein the weight percentage of the lactic acid is 0.2 percent, and the weight percentage of the parachlorometaxylenol is 0.2 percent.
Specifically, the humectant is a mixture of glycerol, propylene glycol and PEG-7 glyceryl cocoate. Wherein the weight percentage of the glycerol is 1.5 percent, the weight percentage of the propylene glycol is 1.5 percent, and the weight percentage of the PEG-7 glycerol cocoate is 0.1 percent.
Specifically, the auxiliary agent is disodium ethylene diamine tetraacetate.
Specifically, the preservative is a mixture of methylchloroisothiazolinone and methylisothiazolinone.
The preparation method comprises the following steps: adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, solubilizer, sodium hydroxide, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed.
Example 2
The formula (comprising the following components in parts by weight): 4% of alkyl glycoside; 5% of fatty alcohol-polyoxyethylene ether sodium sulfate; 2% of lauramidopropyl betaine; 3.1% of a humectant; 0.1% of preservative; 0.3 percent of essence; 0.4 percent of bacteriostatic agent; 0.013 percent of sodium hydroxide; 0.05% of an auxiliary agent; the water is added to 100 percent.
Specifically, the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol. Wherein the weight percentage of the lactic acid is 0.2 percent, and the weight percentage of the parachlorometaxylenol is 0.2 percent.
Specifically, the humectant is a mixture of glycerol, propylene glycol and PEG-7 glyceryl cocoate. Wherein the weight percentage of the glycerol is 1.5 percent, the weight percentage of the propylene glycol is 1.5 percent, and the weight percentage of the PEG-7 glycerol cocoate is 0.1 percent.
Specifically, the auxiliary agent is disodium ethylene diamine tetraacetate.
Specifically, the preservative is a mixture of methylchloroisothiazolinone and methylisothiazolinone.
The preparation method comprises the following steps: adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, bacteriostatic agent, sodium hydroxide, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed.
Example 3
The formula (comprising the following components in parts by weight): 2% of alkyl glycoside; 7% of fatty alcohol-polyoxyethylene ether sodium sulfate; 3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.1% of preservative; 0.3 percent of essence; 0.6 percent of bacteriostatic agent; 0.05% of an auxiliary agent; the water is added to 100 percent.
Specifically, the bacteriostatic agent is a mixture of lactic acid and piroctone olamine salt. Wherein the weight percentage of lactic acid is 0.3%, and the weight percentage of piroctone olamine salt is 0.3%.
Specifically, the humectant is a mixture of glycerol, propylene glycol and PEG-7 glyceryl cocoate. Wherein the weight percentage of the glycerol is 1.5 percent, the weight percentage of the propylene glycol is 1.5 percent, and the weight percentage of the PEG-7 glycerol cocoate is 0.1 percent.
Specifically, the auxiliary agent is disodium ethylene diamine tetraacetate.
Specifically, the preservative is a mixture of methylchloroisothiazolinone and methylisothiazolinone.
The preparation method comprises the following steps: adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, bacteriostatic agent, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed.
Example 4
The formula (comprising the following components in parts by weight): 1% of alkyl glycoside; 8 percent of fatty alcohol-polyoxyethylene ether sodium sulfate; 1% of lauramidopropyl betaine; 3.1% of a humectant; 0.1% of preservative; 0.3 percent of essence; 0.6 percent of bacteriostatic agent; 0.05% of an auxiliary agent; the water is added to 100 percent.
Specifically, the bacteriostatic agent is a mixture of lactic acid and piroctone olamine salt. Wherein the weight percentage of lactic acid is 0.3%, and the weight percentage of piroctone olamine salt is 0.3%.
Specifically, the humectant is a mixture of glycerol, propylene glycol and PEG-7 glyceryl cocoate. Wherein the weight percentage of the glycerol is 1.5 percent, the weight percentage of the propylene glycol is 1.5 percent, and the weight percentage of the PEG-7 glycerol cocoate is 0.1 percent.
Specifically, the auxiliary agent is disodium ethylene diamine tetraacetate.
Specifically, the preservative is a mixture of methylchloroisothiazolinone and methylisothiazolinone.
The preparation method comprises the following steps: adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, bacteriostatic agent, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed.
Comparative example 1
The formula (comprising the following components in parts by weight): 2% of alkyl glycoside; 7% of fatty alcohol-polyoxyethylene ether sodium sulfate; 3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.08 percent of preservative; 0.3 percent of essence; 0.3 percent of bacteriostatic agent; citric acid monohydrate 0.24%; 0.05% of an auxiliary agent; the water is added to 100 percent.
Specifically, the bacteriostatic agent is piroctone olamine.
Specifically, the humectant is a mixture of glycerol, propylene glycol and PEG-7 glyceryl cocoate. Wherein the weight percentage of the glycerol is 1.5 percent, the weight percentage of the propylene glycol is 1.5 percent, and the weight percentage of the PEG-7 glycerol cocoate is 0.1 percent.
Specifically, the auxiliary agent is disodium ethylene diamine tetraacetate.
Specifically, the preservative is a mixture of methylchloroisothiazolinone and methylisothiazolinone.
The preparation method comprises the following steps: adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, bacteriostatic agent, citric acid monohydrate, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed.
Comparative example 2
The formula (comprising the following components in parts by weight): 2% of alkyl glycoside; 7% of fatty alcohol-polyoxyethylene ether sodium sulfate; 3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.08 percent of preservative; 0.3 percent of essence; 1% of bacteriostatic agent; 0.25 percent of sodium hydroxide; 0.05% of an auxiliary agent; the water is added to 100 percent.
Specifically, the bacteriostatic agent is lactic acid.
Specifically, the humectant is a mixture of glycerol, propylene glycol and PEG-7 glyceryl cocoate. Wherein the weight percentage of the glycerol is 1.5 percent, the weight percentage of the propylene glycol is 1.5 percent, and the weight percentage of the PEG-7 glycerol cocoate is 0.1 percent.
Specifically, the auxiliary agent is disodium ethylene diamine tetraacetate.
Specifically, the preservative is a mixture of methylchloroisothiazolinone and methylisothiazolinone.
The preparation method comprises the following steps: adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, bacteriostatic agent, sodium hydroxide, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed.
Comparative example 3
The formula (comprising the following components in parts by weight): 2% of alkyl glycoside; 7% of fatty alcohol-polyoxyethylene ether sodium sulfate; 3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.08 percent of preservative; 0.3 percent of essence; 0.3 percent of bacteriostatic agent; citric acid monohydrate 0.24%; 0.05% of an auxiliary agent; the water is added to 100 percent.
The bacteriostatic agent is parachlorometaxylenol.
Specifically, the humectant is a mixture of glycerol, propylene glycol and PEG-7 glyceryl cocoate. Wherein the weight percentage of the glycerol is 1.5 percent, the weight percentage of the propylene glycol is 1.5 percent, and the weight percentage of the PEG-7 glycerol cocoate is 0.1 percent.
The auxiliary agent is disodium ethylene diamine tetraacetate.
The preservative is a mixture of methylchloroisothiazolinone and methylisothiazolinone.
The preparation method comprises the following steps: adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, bacteriostatic agent, citric acid monohydrate, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed.
TABLE 1 examples and comparative examples detergent composition formulations Components and weight percentages
Test example one, the bacteriostatic activity of the bacteriostatic hand sanitizer of the invention
According to QBT 2738-. The antibacterial rate is more than or equal to 50 percent, and the product has the antibacterial effect.
TABLE 2 bacteriostatic Properties of the bacteriostatic hand-washing solutions
From table 2 above, it can be seen that:
(1) the bacteriostatic hand sanitizer disclosed by the embodiment 1-4 has a bacteriostatic effect on escherichia coli 8099, staphylococcus aureus ATCC6538 and candida albicans ATCC 10231. The bacteriostatic agent of the bacteriostatic hand sanitizer is a mixture of lactic acid and parachlorometaxylenol, wherein lactic acid can regulate pH and can also synergistically act with the parachlorometaxylenol to improve the bactericidal effect, and the sterilization rates of the lactic acid to escherichia coli 8099, staphylococcus aureus ATCC6538 and candida albicans ATCC10231 are all above 99.90%; the bacteriostatic agents of the bacteriostatic hand sanitizer in embodiments 3 and 4 are the mixture of lactic acid and piroctone olamine, and the lactic acid can not only adjust the pH, but also have a synergistic effect with the piroctone olamine, so that the bactericidal effect is improved. Example 3 the sterilization rate for Escherichia coli 8099 and Staphylococcus aureus ATCC6538 were both above 99.90%, and the sterilization rate for Candida albicans ATCC10231 was 80%; example 4 the sterilization rate was above 99.90% for both E.coli 8099 and Staphylococcus aureus ATCC6538, and 82% for Candida albicans ATCC 10231.
(2) Compared with the embodiment 3 or the embodiment 4, the comparative example 1 of the invention lacks certain bacteriostatic agent (lactic acid) in the formula of the invention, so that the bacteriostatic effect of the system is obviously deteriorated; has antibacterial effect on Escherichia coli 8099 and Staphylococcus aureus ATCC6538, but has no antibacterial effect on Candida albicans ATCC 10231; compared with example 3 or example 4, the comparative example 2 lacks the use of a certain bacteriostatic agent (piroctone olamine) in the formula of the invention, and compared with example 1 or example 2, the comparative example 2 lacks the use of a certain bacteriostatic agent (parachlorometaxylenol) in the formula of the invention, so that the bacteriostatic effect of the system is obviously worse; although the antibacterial effect is achieved on staphylococcus aureus ATCC6538, the antibacterial effect is not achieved on escherichia coli 8099 and candida albicans ATCC 10231; compared with the embodiment 1 or 2, the comparative example 3 lacks certain bacteriostatic agent (lactic acid) in the formula of the invention, so that the bacteriostatic effect of the system is obviously deteriorated; although having bacteriostatic action on staphylococcus aureus ATCC6538, it has no bacteriostatic action on Escherichia coli 8099 and Candida albicans ATCC 10231.
Test example II, stability of the bacteriostatic hand sanitizer
The appearance, high-temperature stability and low-temperature stability of the bacteriostatic hand sanitizer prepared in the examples 1-4 are examined, and the results are shown in the following table 3.
Table 3 stability evaluation of each bacteriostatic hand sanitizer
From table 3 above, it can be seen that:
(1) the antibacterial hand sanitizer disclosed in the embodiments 1-4 of the invention has the advantages of transparent and clear appearance, no precipitate, good stability at high and low temperatures, and high stability of a system, and is suitable for high-temperature or low-temperature rinsing.
(2) The parachlorometaxylenol or piroctone olamine salt of the antibacterial hand sanitizer disclosed by the embodiments 1-4 of the invention is compatible with the components such as lactic acid, alkyl glycoside, fatty alcohol-polyoxyethylene ether sodium sulfate and lauramidopropyl betaine, and the like, and the components act synergistically, so that the system is endowed with higher stability.
Although the present invention is disclosed above, the present invention is not limited thereto. Various changes and modifications may be effected therein by one skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (8)
1. The bacteriostatic hand sanitizer is characterized by comprising the following raw material components in percentage by weight: 1-10% of alkyl glycoside; 5-20% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-10% of lauramidopropyl betaine; 1-10% of a humectant; 0.05 to 0.9 percent of preservative; 0.1 to 0.5 percent of essence; 0.2 to 1 percent of bacteriostatic agent; citric acid monohydrate 0-1%; 0-1% of sodium hydroxide; 0.05 to 0.2 percent of auxiliary agent and water which is complemented to 100 percent; the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol, or the bacteriostatic agent is a mixture of lactic acid and piroctone olamine.
2. The bacteriostatic hand sanitizer according to claim 1, which comprises the following raw material components in percentage by weight: 1-4% of alkyl glycoside; 5-8% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.08 percent of preservative; 0.3 percent of essence; 0.4 to 0.6 percent of bacteriostatic agent; 0-0.013% of sodium hydroxide; 0.05% of auxiliary agent and water which is complemented to 100%; the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol, or the bacteriostatic agent is a mixture of lactic acid and piroctone olamine.
3. The bacteriostatic hand sanitizer according to claim 2, which comprises the following raw material components in percentage by weight: 2-4% of alkyl glycoside; 5-7% of fatty alcohol-polyoxyethylene ether sodium sulfate; 2-3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.08 percent of preservative; 0.3 percent of essence; 0.4 percent of bacteriostatic agent; 0.013 percent of sodium hydroxide; 0.05% of an auxiliary agent; water to 100%; the bacteriostatic agent is a mixture of lactic acid and parachlorometaxylenol.
4. The bacteriostatic hand sanitizer according to claim 2, which comprises the following raw material components in percentage by weight: 1-2% of alkyl glycoside; 7-8% of fatty alcohol-polyoxyethylene ether sodium sulfate; 1-3.2% of lauramidopropyl betaine; 3.1% of a humectant; 0.08 percent of preservative; 0.3 percent of essence; 0.6 percent of bacteriostatic agent; 0.05% of an auxiliary agent; water to 100%; the bacteriostatic agent is a mixture of lactic acid and piroctone olamine.
5. The bacteriostatic hand sanitizer according to claim 1, wherein the humectant is one or a mixture of two or more of glycerin, propylene glycol, PEG400 and PEG-7 glyceryl cocoate.
6. The bacteriostatic hand sanitizer according to claim 1, wherein the auxiliary agent is one or a mixture of two of disodium ethylenediamine tetraacetic acid and sodium citrate.
7. The bacteriostatic hand sanitizer according to claim 1, wherein the preservative is one or a mixture of more than two of sodium benzoate, phenoxyethanol, ethylhexyl glycerol, methylchloroisothiazolinone and methylisothiazolinone.
8. A method for preparing a bacteriostatic hand sanitizer according to any one of claims 1 to 7, wherein the method comprises the following steps: adding water into a reaction kettle; then sequentially adding alkyl glycoside, fatty alcohol-polyoxyethylene ether sodium sulfate, lauramidopropyl betaine, bacteriostatic agent, citric acid monohydrate, sodium hydroxide, humectant, auxiliary agent, preservative and essence; stirring until uniformly mixed.
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| CN202010082252.9A CN113244129A (en) | 2020-02-07 | 2020-02-07 | Antibacterial hand sanitizer and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115919669A (en) * | 2022-11-21 | 2023-04-07 | 丹东欣时代生物医药科技有限公司 | Low-ethanol compound hand-washing-free disinfectant applicable to low temperature and preparation method thereof |
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| EP0882446A1 (en) * | 1997-06-02 | 1998-12-09 | Gojo Industries,Inc. | Antimicrobial skin cleansing compositions |
| CN107095829A (en) * | 2017-04-28 | 2017-08-29 | 郑州人造金刚石及制品工程技术研究中心有限公司 | A kind of bacteriostatic hand sanitizer containing nanometer carbon crystal element and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115919669A (en) * | 2022-11-21 | 2023-04-07 | 丹东欣时代生物医药科技有限公司 | Low-ethanol compound hand-washing-free disinfectant applicable to low temperature and preparation method thereof |
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Application publication date: 20210813 |