CN119307331A - A liquid cleaning agent based on hydrogen peroxide and a preparation method thereof - Google Patents
A liquid cleaning agent based on hydrogen peroxide and a preparation method thereof Download PDFInfo
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- CN119307331A CN119307331A CN202411844738.6A CN202411844738A CN119307331A CN 119307331 A CN119307331 A CN 119307331A CN 202411844738 A CN202411844738 A CN 202411844738A CN 119307331 A CN119307331 A CN 119307331A
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- mixed solution
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- hydrogen peroxide
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims abstract description 146
- 239000012459 cleaning agent Substances 0.000 title claims abstract description 55
- 239000007788 liquid Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 78
- 102000004190 Enzymes Human genes 0.000 claims abstract description 62
- 108090000790 Enzymes Proteins 0.000 claims abstract description 62
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 48
- 238000005260 corrosion Methods 0.000 claims abstract description 40
- 230000007797 corrosion Effects 0.000 claims abstract description 40
- 239000003112 inhibitor Substances 0.000 claims abstract description 35
- 239000002131 composite material Substances 0.000 claims abstract description 21
- 239000006084 composite stabilizer Substances 0.000 claims abstract description 19
- 108091005804 Peptidases Proteins 0.000 claims abstract description 17
- 239000004365 Protease Substances 0.000 claims abstract description 17
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 17
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 16
- 239000011701 zinc Substances 0.000 claims abstract description 16
- UIGXGNUMMVHJKX-UHFFFAOYSA-N (4-formylphenoxy)boronic acid Chemical compound OB(O)OC1=CC=C(C=O)C=C1 UIGXGNUMMVHJKX-UHFFFAOYSA-N 0.000 claims abstract description 14
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 14
- 239000011259 mixed solution Substances 0.000 claims description 104
- 238000002156 mixing Methods 0.000 claims description 89
- 239000000654 additive Substances 0.000 claims description 65
- 230000000996 additive effect Effects 0.000 claims description 60
- 229940088598 enzyme Drugs 0.000 claims description 60
- 238000003756 stirring Methods 0.000 claims description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 claims description 23
- 239000008367 deionised water Substances 0.000 claims description 22
- 229910021641 deionized water Inorganic materials 0.000 claims description 22
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 claims description 20
- 239000012964 benzotriazole Substances 0.000 claims description 20
- 239000000344 soap Substances 0.000 claims description 20
- 239000004094 surface-active agent Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 17
- 239000004382 Amylase Substances 0.000 claims description 16
- 108010065511 Amylases Proteins 0.000 claims description 16
- 102000013142 Amylases Human genes 0.000 claims description 16
- 239000004367 Lipase Substances 0.000 claims description 16
- 102000004882 Lipase Human genes 0.000 claims description 16
- 108090001060 Lipase Proteins 0.000 claims description 16
- 235000019418 amylase Nutrition 0.000 claims description 16
- 235000019421 lipase Nutrition 0.000 claims description 16
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 15
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 11
- 239000001110 calcium chloride Substances 0.000 claims description 11
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10
- BAERPNBPLZWCES-UHFFFAOYSA-N (2-hydroxy-1-phosphonoethyl)phosphonic acid Chemical compound OCC(P(O)(O)=O)P(O)(O)=O BAERPNBPLZWCES-UHFFFAOYSA-N 0.000 claims description 8
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical group C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims description 8
- 108010059892 Cellulase Proteins 0.000 claims description 8
- 102000016943 Muramidase Human genes 0.000 claims description 8
- 108010014251 Muramidase Proteins 0.000 claims description 8
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 8
- 229940106157 cellulase Drugs 0.000 claims description 8
- 239000004325 lysozyme Substances 0.000 claims description 8
- 229960000274 lysozyme Drugs 0.000 claims description 8
- 235000010335 lysozyme Nutrition 0.000 claims description 8
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 8
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 8
- 239000000176 sodium gluconate Substances 0.000 claims description 8
- 235000012207 sodium gluconate Nutrition 0.000 claims description 8
- 229940005574 sodium gluconate Drugs 0.000 claims description 8
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 8
- 239000003381 stabilizer Substances 0.000 claims description 8
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 8
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 8
- 239000000811 xylitol Substances 0.000 claims description 8
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 8
- 229960002675 xylitol Drugs 0.000 claims description 8
- 235000010447 xylitol Nutrition 0.000 claims description 8
- 239000003599 detergent Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5
- 239000001488 sodium phosphate Substances 0.000 claims description 5
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 5
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 5
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 4
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims description 4
- JMHWNJGXUIJPKG-UHFFFAOYSA-N CC(=O)O[SiH](CC=C)OC(C)=O Chemical compound CC(=O)O[SiH](CC=C)OC(C)=O JMHWNJGXUIJPKG-UHFFFAOYSA-N 0.000 claims description 3
- FOAXVTDZLJHMMA-UHFFFAOYSA-M decyl-dimethyl-octylazanium;bromide Chemical compound [Br-].CCCCCCCCCC[N+](C)(C)CCCCCCCC FOAXVTDZLJHMMA-UHFFFAOYSA-M 0.000 claims description 3
- SCXCDVTWABNWLW-UHFFFAOYSA-M decyl-dimethyl-octylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCC SCXCDVTWABNWLW-UHFFFAOYSA-M 0.000 claims description 3
- UMGXUWVIJIQANV-UHFFFAOYSA-M didecyl(dimethyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC UMGXUWVIJIQANV-UHFFFAOYSA-M 0.000 claims description 3
- APTVNWGLSRAOFJ-UHFFFAOYSA-M dimethyl(dioctyl)azanium;bromide Chemical compound [Br-].CCCCCCCC[N+](C)(C)CCCCCCCC APTVNWGLSRAOFJ-UHFFFAOYSA-M 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 claims description 2
- 235000019419 proteases Nutrition 0.000 claims description 2
- 229960004418 trolamine Drugs 0.000 claims 3
- ICLYJLBTOGPLMC-KVVVOXFISA-N (z)-octadec-9-enoate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCC\C=C/CCCCCCCC(O)=O ICLYJLBTOGPLMC-KVVVOXFISA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940117013 triethanolamine oleate Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 238000003860 storage Methods 0.000 abstract description 8
- 244000052769 pathogen Species 0.000 abstract description 7
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 31
- 238000004659 sterilization and disinfection Methods 0.000 description 21
- 238000004140 cleaning Methods 0.000 description 15
- 230000001954 sterilising effect Effects 0.000 description 13
- 230000009972 noncorrosive effect Effects 0.000 description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000000645 desinfectant Substances 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000001590 oxidative effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- RHDGPGHQFICLKH-UHFFFAOYSA-N anisole propane-1,2-diol Chemical compound CC(O)CO.COC1=CC=CC=C1 RHDGPGHQFICLKH-UHFFFAOYSA-N 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 230000003588 decontaminative effect Effects 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229940126062 Compound A Drugs 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- -1 hydroxyl free radical Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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- 239000002957 persistent organic pollutant Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 description 1
Landscapes
- Detergent Compositions (AREA)
Abstract
本发明涉及医疗器械清洗剂领域，具体涉及一种基于过氧化氢的液体清洗剂及其制备方法，所述液体清洗剂包括A剂和B剂；所述A剂和B剂的质量比为60‑70:30‑40；本发明A剂中通过引入双链季铵盐和PCA锌，可加速过氧化氢分子与病原体的接触，在较短的时间内实现病原体的灭杀，B剂中的4‑甲酰苯基硼酸在储存时能有效抑制蛋白酶活力，防止蛋白酶水解，对酶起到了保护作用，复配A剂中的过氧化氢则可以在使用过程中使酶活力慢慢恢复，使得酶可以最大程度发挥作用，加入的复合稳定剂和丙三醇对蛋白酶有稳定作用，防止酶活性的降低，复合缓蚀剂和缓蚀剂则可以有效防止医疗器械被清洗剂腐蚀，因此具有广泛的应用前景。The invention relates to the field of medical device cleaning agents, and in particular to a liquid cleaning agent based on hydrogen peroxide and a preparation method thereof. The liquid cleaning agent comprises an agent A and an agent B; the mass ratio of the agent A to the agent B is 60-70:30-40; the agent A of the invention introduces a double-chain quaternary ammonium salt and PCA zinc, thereby accelerating the contact between hydrogen peroxide molecules and pathogens, and achieving pathogen killing in a relatively short time; the 4-formylphenylboric acid in the agent B can effectively inhibit protease activity during storage, prevent protease hydrolysis, and protect the enzyme; the hydrogen peroxide in the compounded agent A can slowly restore the enzyme activity during use, so that the enzyme can play a role to the maximum extent; the added composite stabilizer and glycerol have a stabilizing effect on the protease, and prevent the enzyme activity from being reduced; the composite corrosion inhibitor and the corrosion inhibitor can effectively prevent the medical device from being corroded by the cleaning agent, and therefore has a wide application prospect.
Description
Technical Field
The invention relates to the field of medical instrument cleaning agents, in particular to a liquid cleaning agent based on hydrogen peroxide and a preparation method thereof.
Background
The medical instrument cleaning, disinfection and sterilization are the key for preventing and controlling the nosocomial infection, the medical quality is guaranteed, good cleaning is the precondition of disinfection and sterilization, if the medical instrument is not sufficiently cleaned, the disinfection and sterilization also fail, so the cleaning quality directly affects the medical care quality and the security risk of patients, the difficulty degree of cleaning in the treatment process is continuously improved along with the gradual use of more complex medical instruments in hospitals, and the use of the cleaning agent plays a decisive role in effective cleaning.
In addition, after the medical instrument is used, organic pollutants such as blood stains and grease tissue fluid are often remained on the surface of the medical instrument, in addition, the accumulation of biological films can be caused in the repeated use of a plurality of medical instruments, the biological films have great harm, 2400 times of antibiotic consumption is needed after the biological films are formed, the mortality rate is as high as 50% -60%, if the bacterial in the biological films are killed by means of disinfection/sterilization and the like, the infection risk can be effectively reduced only by thoroughly cleaning the biological films, and qualified sterilization cannot be caused without high-quality cleaning, however, the main problem of the existing cleaning agent is that the cleaning is incomplete, so that the pollutants remain on the surface of the instrument, the service life of the instrument is greatly shortened besides the instrument is greatly damaged.
The conventional high-efficiency disinfection cleaning agent usually contains chloride ions, is easy to remain and causes corrosion of medical instruments, ultraviolet disinfection cannot enter dead angles of the medical instruments, the effect is difficult to ensure, and the hydrogen peroxide disinfectant is a high-efficiency disinfectant with strong oxidizing property and has the characteristics of no residue, greenness and no pollution after use. The hydrogen peroxide molecule releases hydroxyl free radical and nascent state atoms with strong oxidizing ability in water, and the active particles can destroy the protein structure of the microorganism once contacting the microorganism, so that the microorganism dies and the effect of inactivating the microorganism is achieved. However, hydrogen peroxide molecules are not stable enough, so that some stabilizers are usually added during storage to ensure the content of hydrogen peroxide and reduce the decomposition, and the conventional stabilizers inhibit the decomposition of hydrogen peroxide and reduce the reactivity of hydrogen peroxide. Therefore, the hydrogen peroxide disinfectant in the market has high concentration (generally 3%), and has certain potential safety hazard in the storage and use processes. Meanwhile, the high-concentration hydrogen peroxide causes waste of raw materials, and does not accord with the concept of green chemistry.
Therefore, according to the related art described above, there is a need to develop a liquid cleaning agent based on hydrogen peroxide and a method for preparing the same.
Disclosure of Invention
In view of the above, the invention aims to provide a liquid cleaning agent based on hydrogen peroxide and a preparation method thereof, so as to solve the problems of weak sterilization capability and poor storage stability of the disinfection cleaning agent for medical instruments in the prior art.
Based on the above purpose, the invention provides a liquid cleaning agent based on hydrogen peroxide and a preparation method thereof.
A liquid hydrogen peroxide-based cleaning agent, the liquid cleaning agent comprising an agent a and an agent B;
the mass ratio of the agent A to the agent B is 60-70:30-40;
The agent A is prepared from hydrogen peroxide, double-chain quaternary ammonium salt, PCA zinc, a composite stabilizer, a composite corrosion inhibitor and a pH regulator;
the agent B is prepared from triethanolamine oleic soap, benzotriazole, propylene glycol monomethyl ether, glycerol, an additive, a surfactant, a corrosion inhibitor and deionized water;
the additive is obtained by mixing a multienzyme additive and an auxiliary enzyme additive in a mass ratio of 3-4:1-2;
The multienzyme additive is prepared from the following raw materials of calcium chloride, 4-formylphenyl boric acid, propylene glycol monomethyl ether, glycerol and complex enzyme.
Preferably, the preparation process of the agent A is as follows:
Step A1, adding hydrogen peroxide into deionized water, and stirring for 5-7min at a rotating speed of 60-90r/min to obtain a mixed solution A1;
A2, adding the composite stabilizer into the mixed solution A1, and stirring for 5-7min at the rotating speed of 60-90r/min to obtain mixed solution A2;
a3, adding the double-chain quaternary ammonium salt into the mixed solution A2, and stirring for 5-7min at the rotating speed of 60-90r/min to obtain a mixed solution A3;
A4, adding PCA zinc into the mixed solution A3, and stirring for 5-7min at a rotating speed of 60-90r/min to obtain a mixed solution A4;
a5, adding the composite corrosion inhibitor into the mixed solution A4, and stirring for 5-7min at the rotating speed of 60-90r/min to obtain mixed solution A5;
And step A6, adding the pH regulator into the mixed solution A5, and stirring for 14-16min at the rotating speed of 60-90r/min to obtain the agent A.
Preferably, the mass ratio of the hydrogen peroxide to the deionized water in the step A1 is 0.875-1.15:80-85;
the mass ratio of the composite stabilizer to the mixed solution A1 in the step A2 is 0.05-0.15:80-85;
The compound stabilizer in the step A2 is obtained by mixing sodium pyrophosphate and hydroxyethylidene diphosphonic acid according to the mass ratio of 1.8-2.2:0.8-1.2.
Preferably, in the step A3, the mass ratio of the double-chain quaternary ammonium salt to the mixed solution A2 is 0.18-0.22:80-85;
The double-chain quaternary ammonium salt in the step A3 is any one of didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, octyl decyl dimethyl ammonium chloride, octyl decyl dimethyl ammonium bromide, dioctyl dimethyl ammonium chloride and dioctyl dimethyl ammonium bromide;
The mass ratio of the PCA zinc to the mixed liquor A3 in the step A4 is 0.6-1.5:80-85.
Preferably, the mass ratio of the composite corrosion inhibitor to the mixed solution A4 in the step A5 is 0.08-0.2:80-85;
the composite corrosion inhibitor in the step A5 is obtained by mixing thiourea and benzotriazole in a mass ratio of 0.8-1.2:1.8-2.2;
the mass ratio of the pH regulator to the mixed solution A5 in the step A6 is 0.1-0.2:80-85;
the pH regulator in the step A6 is any one of phosphoric acid and sodium phosphate.
Preferably, the preparation process of the agent B is as follows:
step B1, uniformly mixing the multienzyme additive and the auxiliary enzyme additive to obtain an additive;
B2, dispersing triethanolamine oleic soap, benzotriazole, propylene glycol monomethyl ether, glycerol and additives in deionized water, and uniformly mixing to obtain a mixed solution B1;
And step B3, adding a surfactant and a corrosion inhibitor into the mixed solution B1, and uniformly mixing to obtain the agent B.
Preferably, the preparation process of the multienzyme additive in the step B1 comprises the following steps of mixing calcium chloride, 4-formylphenylboric acid, propylene glycol monomethyl ether, glycerol and compound enzyme, and stirring and mixing at 25-30 ℃ for 30-35min to obtain the multienzyme additive;
the mass ratio of the calcium chloride to the 4-formylphenyl boric acid to the propylene glycol monomethyl ether to the glycerol to the complex enzyme in the step B1 is 4-5:0.6-0.8:2-3:6-8:3-5;
The complex enzyme is obtained by mixing protease, lipase, xylitol enzyme, cellulase and amylase in a mass ratio of 10-12:4-6:1-3:0.8-1.2:0.8-1.2;
The auxiliary enzyme additive in the step B1 is obtained by mixing lysozyme, amylase and lipase according to a mass ratio of 6-9:2-5:2-6.
Preferably, in the step B2, the mass ratio of the triethanolamine oleic soap, the benzotriazole, the propylene glycol monomethyl ether, the glycerol, the additive and the deionized water is 8-12:0.4-0.6:1-2:1-1.5:3-5:54.9-67.6;
and B3, wherein the mass ratio of the mixed solution B1 to the surfactant to the corrosion inhibitor is 66.9-86.6:16-20:2.5-4.
Preferably, the surfactant in the step B3 is obtained by mixing triethanolamine oleic soap and AEO-9 according to a mass ratio of 8-12:38-42;
And B3, wherein the corrosion inhibitor is sodium gluconate.
A method for preparing a liquid cleaning agent based on hydrogen peroxide, comprising the following steps:
And uniformly mixing the agent A and the agent B to obtain the liquid cleaning agent based on hydrogen peroxide.
The invention has the beneficial effects that:
the invention provides a liquid cleaning agent based on hydrogen peroxide and a preparation method thereof, wherein double-chain quaternary ammonium salt and PCA zinc are introduced into the agent A, in the cleaning process, the double-chain quaternary ammonium salt can neutralize charges on the surfaces of bacteria and viruses, thereby promoting the aggregation of pathogens and accelerating the contact of hydrogen peroxide molecules with the pathogens, meanwhile, when the double-chain quaternary ammonium salt is absorbed and consumed, PCA zinc in the system can be partially hydrolyzed to generate nano zinc oxide, so that hydroxyl free radicals with stronger oxidizing ability can be generated by activating the decomposition of hydrogen peroxide, and the killing of the pathogens can be realized in a shorter time;
The invention provides a liquid cleaning agent based on hydrogen peroxide and a preparation method thereof, wherein 4-formylphenylboric acid introduced in the agent B can effectively inhibit protease activity during storage, prevent protease from hydrolyzing or being hydrolyzed by other enzymes, protect the enzymes, hydrogen peroxide in the agent A can slowly recover the enzyme activity during use, so that the enzymes can play a role to the greatest extent, propylene glycol anisole can serve as an auxiliary additive for dissolution, the hydrogen bond formed by the added compound stabilizer and glycerol has smaller capability than water, the destructive power on the hydrogen bond structure of protein molecules is smaller, the protease can be stabilized by taking the water as a solvent instead of the water, the damage on the enzymes is reduced by forming a cooperation effect, the reduction of the enzyme activity is prevented, and the introduced compound corrosion inhibitor and corrosion inhibitor can effectively realize the purposes of cleaning, sterilizing and preventing the medical instruments from being corroded by the cleaning agent, so that the liquid cleaning agent has wide application prospect.
Detailed Description
The present invention will be further described in detail with reference to specific embodiments in order to make the objects, technical solutions and advantages of the present invention more apparent.
Example 1a method for preparing a liquid hydrogen peroxide-based cleaning agent comprising the steps of:
s1, adding 0.875g of hydrogen peroxide into 80g of deionized water, and stirring for 5min at a rotating speed of 60r/min to obtain a mixed solution A1;
s2, uniformly mixing 1.8g of sodium pyrophosphate and 0.8g of hydroxyethylidene diphosphonic acid to obtain a composite stabilizer;
s3, adding 0.05g of the composite stabilizer into 80g of the mixed solution A1, and stirring for 5min at the rotating speed of 60r/min to obtain a mixed solution A2;
s3, adding 0.18g of didecyl dimethyl ammonium chloride into 80g of mixed solution A2, and stirring for 5min at a rotating speed of 60r/min to obtain mixed solution A3;
S4, adding 0.6gPCA zinc into 80g of mixed solution A3, and stirring for 5min at the rotating speed of 60r/min to obtain mixed solution A4;
s5, uniformly mixing 0.8g of thiourea and 1.8g of benzotriazole to obtain a composite corrosion inhibitor;
S6, adding 0.08g of the composite corrosion inhibitor into 80g of the mixed solution A4, and stirring for 5min at the rotating speed of 60r/min to obtain a mixed solution A5;
S7, adding 0.1g of phosphoric acid into 80g of mixed solution A5, and stirring for 14min at the rotating speed of 60r/min to obtain a reagent A;
S8, uniformly mixing 10g of protease, 4g of lipase, 1g of xylitol enzyme, 0.8g of cellulase and 0.8g of amylase to obtain a compound enzyme;
S9, mixing 4g of calcium chloride, 0.6g of 4-formylphenyl boric acid, 2g of propylene glycol monomethyl ether, 6g of glycerol and 3g of complex enzyme, and stirring and mixing at 25 ℃ for 30min to obtain a multienzyme additive;
s10, uniformly mixing 6g of lysozyme, 2g of amylase and 2g of lipase to obtain an auxiliary enzyme additive;
S11, mixing 3g of a multienzyme additive and 1g of an auxiliary enzyme additive to obtain an additive;
S12, dispersing 8g of triethanolamine oleic soap, 0.4g of benzotriazole, 1g of propylene glycol monomethyl ether, 1g of glycerol and 3g of additive in 54.9g of deionized water, and uniformly mixing to obtain a mixed solution B1;
S13, uniformly mixing 8g of triethanolamine oleic soap and 38gAEO-9 to obtain a surfactant;
s14, adding 16g of surfactant and 2.5g of sodium gluconate into 66.9g of mixed solution B1, and uniformly mixing to obtain a preparation B;
S15, uniformly mixing 60gA agents and 30gB agents to obtain the liquid cleaning agent based on hydrogen peroxide.
Example 2a method for preparing a liquid hydrogen peroxide based cleaning agent comprising the steps of:
S1, adding 0.9g of hydrogen peroxide into 81g of deionized water, and stirring for 6min at a rotating speed of 65r/min to obtain a mixed solution A1;
s2, uniformly mixing 1.85g of sodium pyrophosphate and 0.9g of hydroxyethylidene diphosphonic acid to obtain a composite stabilizer;
S3, adding 0.07g of the composite stabilizer into 81g of the mixed solution A1, and stirring for 6min at the rotating speed of 65r/min to obtain mixed solution A2;
S3, adding 0.19g of didecyl dimethyl ammonium bromide into 81g of mixed solution A2, and stirring for 6min at a rotating speed of 65r/min to obtain mixed solution A3;
S4, adding 0.8gPCA zinc into 81g of mixed solution A3, and stirring for 6min at the rotating speed of 65r/min to obtain mixed solution A4;
s5, uniformly mixing 0.9g of thiourea and 1.9g of benzotriazole to obtain a composite corrosion inhibitor;
S6, adding 0.12g of the composite corrosion inhibitor into 81g of the mixed solution A4, and stirring for 6min at the rotating speed of 65r/min to obtain a mixed solution A5;
S7, adding 0.12g of sodium phosphate into 81g of mixed solution A5, and stirring for 15min at the rotating speed of 65r/min to obtain a reagent A;
s8, uniformly mixing 11g of protease, 4.5g of lipase, 1.5g of xylitol enzyme, 0.9g of cellulase and 0.9g of amylase to obtain a compound enzyme;
S9, mixing 4.2g of calcium chloride, 0.7g of 4-formylphenyl boric acid, 2.2g of propylene glycol monomethyl ether, 6.5g of glycerol and 3.5g of complex enzyme, and stirring and mixing at 26 ℃ for 31min to obtain a multienzyme additive;
S10, uniformly mixing 7g of lysozyme, 3g of amylase and 3g of lipase to obtain an auxiliary enzyme additive;
S11, mixing 3.2g of a multienzyme additive and 1.2g of an auxiliary enzyme additive to obtain an additive;
S12, dispersing 9g of triethanolamine oleic soap, 0.44g of benzotriazole, 1.2g of propylene glycol monomethyl ether, 1.1g of glycerol and 3.4g of additive in 56g of deionized water, and uniformly mixing to obtain a mixed solution B1;
S13, uniformly mixing 9g of triethanolamine oleic soap and 39gAEO-9 to obtain a surfactant;
S14, adding 17g of surfactant and 3g of sodium gluconate into 72g of mixed solution B1, and uniformly mixing to obtain a preparation B;
S15, uniformly mixing the 62gA agent and the 32gB agent to obtain the liquid cleaning agent based on hydrogen peroxide.
Example 3a method for preparing a liquid hydrogen peroxide based cleaning agent comprising the steps of:
S1, adding 1g of hydrogen peroxide into 82g of deionized water, and stirring for 7min at a rotating speed of 70r/min to obtain a mixed solution A1;
S2, uniformly mixing 1.9g of sodium pyrophosphate and 1g of hydroxyethylidene diphosphonic acid to obtain a composite stabilizer;
S3, adding 0.09g of the composite stabilizer into 82g of the mixed solution A1, and stirring for 7min at a rotating speed of 70r/min to obtain a mixed solution A2;
S3, adding 0.2g of octyl decyl dimethyl ammonium chloride into 82g of mixed solution A2, and stirring for 7min at a rotating speed of 70r/min to obtain mixed solution A3;
s4, adding 1gPCA zinc into 82g of mixed solution A3, and stirring for 7min at a rotating speed of 70r/min to obtain mixed solution A4;
s5, uniformly mixing 1g of thiourea and 2g of benzotriazole to obtain a composite corrosion inhibitor;
S6, adding 0.15g of the composite corrosion inhibitor into 82g of the mixed solution A4, and stirring for 7min at the rotating speed of 70r/min to obtain a mixed solution A5;
s7, adding 0.14g of phosphoric acid into 82g of mixed solution A5, and stirring at a rotating speed of 70r/min for 16min to obtain a reagent A;
s8, uniformly mixing 12g of protease, 5g of lipase, 2g of xylitol enzyme, 1g of cellulase and 1g of amylase to obtain a compound enzyme;
s9, mixing 4.4g of calcium chloride, 0.8g of 4-formylphenyl boric acid, 2.4g of propylene glycol monomethyl ether, 6.8g of glycerol and 3.8g of complex enzyme, and stirring and mixing at 27 ℃ for 32min to obtain a multienzyme additive;
s10, uniformly mixing 8g of lysozyme, 4g of amylase and 4g of lipase to obtain an auxiliary enzyme additive;
S11, mixing 3.4g of a multienzyme additive and 1.4g of an auxiliary enzyme additive to obtain an additive;
S12, dispersing 10g of triethanolamine oleic soap, 0.48g of benzotriazole, 1.4g of propylene glycol monomethyl ether, 1.2g of glycerol and 3.8g of additive in 60g of deionized water, and uniformly mixing to obtain a mixed solution B1;
s13, uniformly mixing 10g of triethanolamine oleic soap and 40gAEO-9 to obtain a surfactant;
s14, adding 18g of surfactant and 3.2g of sodium gluconate into 78g of mixed solution B1, and uniformly mixing to obtain a preparation B;
s15, uniformly mixing the 64gA agent and the 34gB agent to obtain the liquid cleaning agent based on hydrogen peroxide.
Example 4a method for preparing a liquid hydrogen peroxide-based cleaning agent comprising the steps of:
S1, adding 1.05g of hydrogen peroxide into 83g of deionized water, and stirring for 5min at a rotating speed of 80r/min to obtain a mixed solution A1;
s2, uniformly mixing 2g of sodium pyrophosphate and 1.1g of hydroxyethylidene diphosphonic acid to obtain a composite stabilizer;
S3, adding 0.11g of the composite stabilizer into 83g of the mixed solution A1, and stirring for 5min at the rotating speed of 80r/min to obtain a mixed solution A2;
S3, adding 0.21g of octyl decyl dimethyl ammonium bromide into 80-81-82-83-84-85g of mixed solution A2, and stirring for 5min at the rotating speed of 80r/min to obtain mixed solution A3;
S4, adding 1.2gPCA zinc into 83g of mixed solution A3, and stirring for 5min at the rotating speed of 80r/min to obtain mixed solution A4;
s5, uniformly mixing 1.1g of thiourea and 2.1g of benzotriazole to obtain a composite corrosion inhibitor;
S6, adding 0.16g of the composite corrosion inhibitor into 83g of the mixed solution A4, and stirring for 5min at the rotating speed of 80r/min to obtain a mixed solution A5;
S7, adding 0.16g of sodium phosphate into 83g of mixed solution A5, and stirring for 14min at the rotating speed of 80r/min to obtain a reagent A;
S8, uniformly mixing 10.5g of protease, 5.5g of lipase, 2.5g of xylitol enzyme, 1.1g of cellulase and 1.1g of amylase to obtain a complex enzyme;
S9, mixing 4.6g of calcium chloride, 0.65g of 4-formylphenyl boric acid, 2.6g of propylene glycol monomethyl ether, 7g of glycerol and 4g of complex enzyme, and stirring and mixing at 28 ℃ for 33min to obtain a multienzyme additive;
S10, uniformly mixing 9g of lysozyme, 5g of amylase and 5g of lipase to obtain an auxiliary enzyme additive;
S11, mixing 3.6g of a multienzyme additive and 1.6g of an auxiliary enzyme additive to obtain an additive;
S12, dispersing 11g of triethanolamine oleic soap, 0.52g of benzotriazole, 1.6g of propylene glycol monomethyl ether, 1.3g of glycerol and 4.2g of additive in 62g of deionized water, and uniformly mixing to obtain a mixed solution B1;
S13, uniformly mixing 11g of triethanolamine oleic soap and 41gAEO-9 to obtain a surfactant;
s14, adding 19g of surfactant and 3.4g of sodium gluconate into 82g of mixed solution B1, and uniformly mixing to obtain a preparation B;
s15, uniformly mixing 66gA agent and 36gB agent to obtain the liquid cleaning agent based on hydrogen peroxide.
Example 5 a method for preparing a liquid hydrogen peroxide-based cleaning agent comprising the steps of:
S1, adding 1.1g of hydrogen peroxide into 84g of deionized water, and stirring for 6min at a rotation speed of 85r/min to obtain a mixed solution A1;
s2, uniformly mixing 2.1g of sodium pyrophosphate and 1.2g of hydroxyethylidene diphosphonic acid to obtain a composite stabilizer;
S3, adding 0.13g of the composite stabilizer into 84g of the mixed solution A1, and stirring for 6min at a rotation speed of 85r/min to obtain a mixed solution A2;
s3, adding 0.22g of dioctyl dimethyl ammonium chloride into 84g of mixed solution A2, and stirring at a rotating speed of 85r/min for 6min to obtain mixed solution A3;
s4, adding 1.3gPCA zinc into 84g of mixed solution A3, and stirring at a rotation speed of 85r/min for 6min to obtain mixed solution A4;
s5, uniformly mixing 1.2g of thiourea and 2.2g of benzotriazole to obtain a composite corrosion inhibitor;
S6, adding 0.18g of the composite corrosion inhibitor into 84g of the mixed solution A4, and stirring at a rotation speed of 85r/min for 6min to obtain a mixed solution A5;
s7, adding 0.18g of phosphoric acid into 84g of mixed solution A5, and stirring at a rotating speed of 85r/min for 15min to obtain a reagent A;
S8, uniformly mixing 11.5g of protease, 6g of lipase, 2.8g of xylitol enzyme, 1.2g of cellulase and 1.2g of amylase to obtain a compound enzyme;
S9, mixing 4.8g of calcium chloride, 0.75g of 4-formylphenyl boric acid, 2.8g of propylene glycol monomethyl ether, 7.5g of glycerol and 4.5g of complex enzyme, and stirring and mixing at 29 ℃ for 34min to obtain a multienzyme additive;
S10, uniformly mixing 7.5g of lysozyme, 3.8g of amylase and 6g of lipase to obtain an auxiliary enzyme additive;
s11, mixing 3.8g of a multienzyme additive and 1.8g of an auxiliary enzyme additive to obtain an additive;
s12, dispersing 12g of triethanolamine oleic soap, 0.56g of benzotriazole, 1.8g of propylene glycol monomethyl ether, 1.4g of glycerol and 4.6g of additive in 64g of deionized water, and uniformly mixing to obtain a mixed solution B1;
s13, uniformly mixing 12g of triethanolamine oleic soap and 42gAEO-9 to obtain a surfactant;
S14, adding 20g of surfactant and 3.6g of sodium gluconate into 85g of mixed solution B1, and uniformly mixing to obtain a preparation B;
S15, uniformly mixing the 68gA agent and the 38gB agent to obtain the liquid cleaning agent based on hydrogen peroxide.
Example 6a method of preparing a liquid hydrogen peroxide-based cleaning agent comprising the steps of:
S1, adding 1.15g of hydrogen peroxide into 85g of deionized water, and stirring for 7min at a rotation speed of 90r/min to obtain a mixed solution A1;
S2, uniformly mixing 2.2g of sodium pyrophosphate and 1g of hydroxyethylidene diphosphonic acid to obtain a composite stabilizer;
S3, adding 0.15g of the composite stabilizer into 85g of the mixed solution A1, and stirring for 7min at the rotating speed of 90r/min to obtain a mixed solution A2;
S3, adding 0.21g of dioctyl dimethyl ammonium bromide into 85g of mixed solution A2, and stirring for 7min at a rotating speed of 90r/min to obtain mixed solution A3;
s4, adding 1.5gPCA zinc into 85g of mixed solution A3, and stirring for 7min at the rotating speed of 90r/min to obtain mixed solution A4;
s5, uniformly mixing 1g of thiourea and 2g of benzotriazole to obtain a composite corrosion inhibitor;
S6, adding 0.2g of the composite corrosion inhibitor into 85g of the mixed solution A4, and stirring for 7min at the rotating speed of 90r/min to obtain a mixed solution A5;
S7, adding 0.2g of sodium phosphate into 85g of mixed solution A5, and stirring for 16min at the rotating speed of 90r/min to obtain a reagent A;
S8, uniformly mixing 11.8g of protease, 5.8g of lipase, 3g of xylitol enzyme, 1g of cellulase and 1g of amylase to obtain a compound enzyme;
s9, mixing 5g of calcium chloride, 0.78g of 4-formylphenyl boric acid, 3g of propylene glycol monomethyl ether, 8g of glycerol and 5g of complex enzyme, and stirring and mixing at 30 ℃ for 35min to obtain a multienzyme additive;
S10, uniformly mixing 8.5g of lysozyme, 4.5g of amylase and 4.5g of lipase to obtain an auxiliary enzyme additive;
s11, mixing 4g of a multienzyme additive and 2g of an auxiliary enzyme additive to obtain an additive;
S12, dispersing 8.8g of triethanolamine oleic soap, 0.6g of benzotriazole, 2g of propylene glycol monomethyl ether, 1.5g of glycerol and 5g of additives in 67.6g of deionized water, and uniformly mixing to obtain a mixed solution B1;
S13, uniformly mixing 10.6g of triethanolamine oleic soap and 40.8gAEO-9 to obtain a surfactant;
S14, adding 18.8g of surfactant and 4g of sodium gluconate into 86.6g of mixed solution B1, and uniformly mixing to obtain a preparation B;
S15, uniformly mixing 70gA agent and 40gB agent to obtain the liquid cleaning agent based on hydrogen peroxide.
Comparative example 1:
in this comparative example, as compared with example 1, no zinc PCA was added during the preparation of the hydrogen peroxide-based liquid detergent, and the remaining steps and parameters were the same, and the detailed description thereof was not repeated, to finally obtain the hydrogen peroxide-based liquid detergent.
Comparative example 2:
Compared with the example 1, the comparative example has no didecyl dimethyl ammonium chloride added in the preparation process of the liquid cleaning agent based on hydrogen peroxide, and the other steps and parameters are the same, so that the comparative example is not repeated, and finally the liquid cleaning agent based on hydrogen peroxide is obtained.
Comparative example 3:
Compared with the comparative example 1, the dosage of the hydrogen peroxide is only adjusted from 0.875g to 0.5g, the rest steps and parameters are the same, and the comparative example is not repeated, so that the liquid cleaning agent based on the hydrogen peroxide is finally obtained.
Comparative example 4:
Compared with the comparative example 1, the dosage of the compound stabilizer is only adjusted from 0.05g to 0.02g, the rest steps and parameters are the same, the comparative example is not repeated, and the liquid cleaning agent based on hydrogen peroxide is finally obtained.
Comparative example 5:
Compared with the comparative example 1, the dosage of the agent A is only adjusted from 60g to 30g, the rest steps and parameters are the same, the comparative example is not repeated, and the liquid cleaning agent based on hydrogen peroxide is finally obtained.
Comparative example 6:
Compared with the comparative example 1, the dosage of the auxiliary enzyme additive is only adjusted from 1g to 3g, the other steps and parameters are the same, and the comparative example is not repeated, so that the liquid cleaning agent based on hydrogen peroxide is finally obtained.
Performance test:
stability test:
The liquid detergents prepared in examples 1 to 6 and comparative examples 1 to 6 were tested for hydrogen peroxide content under normal temperature storage conditions, and the retention rates at 1 week, 4 weeks and 8 weeks were calculated;
and (3) testing disinfection effect:
The sterilization efficiency was measured by a standard suspension method of "sterilization and sanitation Specification (2002 edition)" 2.2.1.4, and sterilization logarithmic values were recorded using liquid cleaning agents stored for 2 weeks after the configuration of example 1 to example 6 and comparative example 1 to comparative example 6;
And (3) cleaning effect test:
The liquid detergents prepared in examples 1 to 6 and comparative examples 1 to 6 were subjected to a cleaning effect test with reference to QB/T1803-1993, GB15979-2002 standards;
Corrosion resistance test:
The corrosiveness of the liquid cleaning agents prepared in examples 1 to 6 and comparative examples 1 to 6 in the present invention on stainless steel was examined according to the "sterilization technical Specification" (2002 edition) item 2.2.1.2.3, item 2.2.1.4, and with reference to GB/T38498-2020 "method for evaluating corrosiveness of disinfectant metals" 5.1, 5.2 and 5.4;
The results are shown in tables 1-3 below:
table 1 summary of the results of the stability experiments for the samples of example 1-example 6 and comparative example 1-comparative example 6
Table 2 summary of the results of the disinfection effect experiments for the samples of example 1-example 6 and comparative example 1-comparative example 6
TABLE 3 summary of the results of the cleaning and Corrosion resistance experiments for the samples of example 1-example 6 and comparative example 1-comparative example 6
| Project | Decontamination rate/% | Protein residual Rate% | Corrosion degree/R (mm/a) |
| Example 1 | 99.5 | 0.2 | 0.004637/Substantially non-corrosive |
| Example 2 | 98.9 | 0.4 | 0.004725/Substantially non-corrosive |
| Example 3 | 98.6 | 0.2 | 0.004653/Substantially non-corrosive |
| Example 4 | 99.2 | 0.3 | 0.004815/Substantially non-corrosive |
| Example 5 | 99.3 | 0.3 | 0.004782/Substantially non-corrosive |
| Example 6 | 99.5 | 0.4 | 0.004826/Substantially non-corrosive |
| Comparative example 1 | 90.5 | 2.2 | 0.005239/Substantially non-corrosive |
| Comparative example 2 | 92.9 | 2.4 | 0.005613/Substantially non-corrosive |
| Comparative example 3 | 91.6 | 2.2 | 0.005239/Substantially non-corrosive |
| Comparative example 4 | 90.2 | 2.3 | 0.005613/Substantially non-corrosive |
| Comparative example 5 | 92.3 | 2.3 | 0.005239/Substantially non-corrosive |
| Comparative example 6 | 93.5 | 2.4 | 0.005613/Substantially non-corrosive |
Data analysis:
As can be seen from Table 1, the liquid cleaning agent prepared by the invention has higher hydrogen peroxide storage stability, as can be seen from Table 2, the liquid cleaning agent prepared by the invention has better disinfection and sterilization effects, as can be seen from Table 3, the liquid cleaning agent prepared by the invention has stronger decontamination rate, lower protein residual rate and good corrosion resistance;
This is probably because the double-stranded quaternary ammonium salt and PCA zinc are introduced, so that the double-stranded quaternary ammonium salt can neutralize charges on the surfaces of bacteria and viruses in the cleaning process, the aggregation of pathogens is promoted, and then the contact between hydrogen peroxide molecules and the pathogens is accelerated;
In addition, the 4-formylphenyl boric acid introduced into the system can effectively inhibit the activity of protease during storage, prevent protease from hydrolyzing or being hydrolyzed by other enzymes, protect the enzymes, the hydrogen peroxide in the compound A agent can slowly recover the activity of the enzymes in the use process, so that the enzymes can play a role to the greatest extent, the propylene glycol anisole can play a role in assisting the dissolution of additives, the hydrogen bond formed by the added compound stabilizer and glycerol is less than that of water, the destructive power of the hydrogen bond structure of protein molecules is also less, the compound stabilizer can replace water to serve as a solvent to stabilize the protease, the complex effect is formed to reduce the damage to the enzymes, the reduction of the activity of the enzymes is prevented, and the introduced compound corrosion inhibitor and corrosion inhibitor can effectively realize the aim of preventing the medical instruments from being corroded by cleaning agents while cleaning, sterilizing the medical instruments, so that the compound corrosion inhibitor has wide application prospects.
It will be appreciated by persons skilled in the art that the above discussion of any embodiment is merely exemplary and is not intended to imply that the scope of the invention is limited to these examples, that combinations of technical features in the above embodiments or in different embodiments may also be implemented in any order, and that many other variations of the different aspects of the invention as described above exist, which are not provided in detail for the sake of brevity.
The present invention is intended to embrace all such alternatives, modifications and variances which fall within the broad scope of the appended claims. Therefore, any omission, modification, equivalent replacement, improvement, etc. of the present invention should be included in the scope of the present invention.
Claims (10)
1. A liquid cleaning agent based on hydrogen peroxide, which is characterized by comprising an agent A and an agent B;
the mass ratio of the agent A to the agent B is 60-70:30-40;
The agent A is prepared from hydrogen peroxide, double-chain quaternary ammonium salt, PCA zinc, a composite stabilizer, a composite corrosion inhibitor and a pH regulator;
the agent B is prepared from triethanolamine oleic soap, benzotriazole, propylene glycol monomethyl ether, glycerol, an additive, a surfactant, a corrosion inhibitor and deionized water;
the additive is obtained by mixing a multienzyme additive and an auxiliary enzyme additive in a mass ratio of 3-4:1-2;
The multienzyme additive is prepared from the following raw materials of calcium chloride, 4-formylphenyl boric acid, propylene glycol monomethyl ether, glycerol and complex enzyme.
2. The liquid hydrogen peroxide-based cleaning agent according to claim 1, wherein the agent a is prepared by the following process:
Step A1, adding hydrogen peroxide into deionized water, and stirring for 5-7min at a rotating speed of 60-90r/min to obtain a mixed solution A1;
A2, adding the composite stabilizer into the mixed solution A1, and stirring for 5-7min at the rotating speed of 60-90r/min to obtain mixed solution A2;
a3, adding the double-chain quaternary ammonium salt into the mixed solution A2, and stirring for 5-7min at the rotating speed of 60-90r/min to obtain a mixed solution A3;
A4, adding PCA zinc into the mixed solution A3, and stirring for 5-7min at a rotating speed of 60-90r/min to obtain a mixed solution A4;
a5, adding the composite corrosion inhibitor into the mixed solution A4, and stirring for 5-7min at the rotating speed of 60-90r/min to obtain mixed solution A5;
And step A6, adding the pH regulator into the mixed solution A5, and stirring for 14-16min at the rotating speed of 60-90r/min to obtain the agent A.
3. The liquid hydrogen peroxide-based cleaning agent according to claim 2, wherein the mass ratio of hydrogen peroxide to deionized water in step A1 is 0.875-1.15:80-85;
the mass ratio of the composite stabilizer to the mixed solution A1 in the step A2 is 0.05-0.15:80-85;
The compound stabilizer in the step A2 is obtained by mixing sodium pyrophosphate and hydroxyethylidene diphosphonic acid according to the mass ratio of 1.8-2.2:0.8-1.2.
4. The liquid detergent based on hydrogen peroxide according to claim 2, wherein the mass ratio of the double-chain quaternary ammonium salt to the mixed liquor A2 in the step A3 is 0.18-0.22:80-85;
The double-chain quaternary ammonium salt in the step A3 is any one of didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, octyl decyl dimethyl ammonium chloride, octyl decyl dimethyl ammonium bromide, dioctyl dimethyl ammonium chloride and dioctyl dimethyl ammonium bromide;
The mass ratio of the PCA zinc to the mixed liquor A3 in the step A4 is 0.6-1.5:80-85.
5. The liquid cleaning agent based on hydrogen peroxide according to claim 2, wherein the mass ratio of the composite corrosion inhibitor to the mixed liquor A4 in the step A5 is 0.08-0.2:80-85;
the composite corrosion inhibitor in the step A5 is obtained by mixing thiourea and benzotriazole in a mass ratio of 0.8-1.2:1.8-2.2;
the mass ratio of the pH regulator to the mixed solution A5 in the step A6 is 0.1-0.2:80-85;
the pH regulator in the step A6 is any one of phosphoric acid and sodium phosphate.
6. The liquid hydrogen peroxide-based cleaning agent according to claim 1, wherein the preparation process of the agent B is as follows:
step B1, uniformly mixing the multienzyme additive and the auxiliary enzyme additive to obtain an additive;
B2, dispersing triethanolamine oleic soap, benzotriazole, propylene glycol monomethyl ether, glycerol and additives in deionized water, and uniformly mixing to obtain a mixed solution B1;
And step B3, adding a surfactant and a corrosion inhibitor into the mixed solution B1, and uniformly mixing to obtain the agent B.
7. The liquid detergent based on hydrogen peroxide according to claim 6, wherein the multi-enzyme additive in the step B1 is prepared by mixing calcium chloride, 4-formylphenylboric acid, propylene glycol monomethyl ether, glycerol and complex enzyme, stirring and mixing at 25-30 ℃ for 30-35min to obtain the multi-enzyme additive;
The complex enzyme is obtained by mixing protease, lipase, xylitol enzyme, cellulase and amylase in a mass ratio of 10-12:4-6:1-3:0.8-1.2:0.8-1.2;
The auxiliary enzyme additive in the step B1 is obtained by mixing lysozyme, amylase and lipase according to a mass ratio of 6-9:2-5:2-6.
8. The liquid hydrogen peroxide-based cleaning agent according to claim 6, wherein the mass ratio of triethanolamine oleic soap, benzotriazole, propylene glycol monomethyl ether, glycerol, additives, and deionized water in step B2 is 8-12:0.4-0.6:1-2:1-1.5:3-5:54.9-67.6;
and B3, wherein the mass ratio of the mixed solution B1 to the surfactant to the corrosion inhibitor is 66.9-86.6:16-20:2.5-4.
9. The liquid hydrogen peroxide-based detergent according to claim 6, wherein the surfactant in the step B3 is a mixture of triethanolamine oleate soap and AEO-9 in a mass ratio of 8-12:38-42;
And B3, wherein the corrosion inhibitor is sodium gluconate.
10. A method for preparing a liquid hydrogen peroxide-based cleaning agent according to any one of claims 1 to 9, comprising the steps of:
And uniformly mixing the agent A and the agent B to obtain the liquid cleaning agent based on hydrogen peroxide.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101945988A (en) * | 2008-02-15 | 2011-01-12 | 宝洁公司 | Cleaning compositions |
| CN103666833A (en) * | 2012-09-22 | 2014-03-26 | 青岛道合生物科技有限公司 | Special antibacterial detergent for tea cup |
| CN105829519A (en) * | 2013-12-18 | 2016-08-03 | 阿科玛股份有限公司 | Stable liquid compositions containing enzymes and peroxides |
| CN106793912A (en) * | 2014-08-01 | 2017-05-31 | 艺康美国股份有限公司 | The method for cleaning and washing the clean textile using the artificial surface of clean textile |
| CN112358916A (en) * | 2020-11-20 | 2021-02-12 | 山东消博士消毒科技股份有限公司 | Multienzyme cleaning solution and preparation method thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101945988A (en) * | 2008-02-15 | 2011-01-12 | 宝洁公司 | Cleaning compositions |
| CN103666833A (en) * | 2012-09-22 | 2014-03-26 | 青岛道合生物科技有限公司 | Special antibacterial detergent for tea cup |
| CN105829519A (en) * | 2013-12-18 | 2016-08-03 | 阿科玛股份有限公司 | Stable liquid compositions containing enzymes and peroxides |
| CN106793912A (en) * | 2014-08-01 | 2017-05-31 | 艺康美国股份有限公司 | The method for cleaning and washing the clean textile using the artificial surface of clean textile |
| CN112358916A (en) * | 2020-11-20 | 2021-02-12 | 山东消博士消毒科技股份有限公司 | Multienzyme cleaning solution and preparation method thereof |
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| CN119307331B (en) | 2025-03-14 |
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Inventor after: Zheng Xuelian Inventor after: Xu Zihao Inventor after: Chen Caiyun Inventor after: Yin Lina Inventor after: Zhou Miao Inventor before: Zheng Xuelian Inventor before: Xu Zihao Inventor before: Chen Caiyun Inventor before: Yin Lina Inventor before: Zhou Miao |