CN112956475A - Foam type peroxyacetic acid disinfectant, and preparation method and use method thereof - Google Patents
Foam type peroxyacetic acid disinfectant, and preparation method and use method thereof Download PDFInfo
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- CN112956475A CN112956475A CN202110096382.2A CN202110096382A CN112956475A CN 112956475 A CN112956475 A CN 112956475A CN 202110096382 A CN202110096382 A CN 202110096382A CN 112956475 A CN112956475 A CN 112956475A
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- acid
- foam
- disinfectant
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- sodium
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- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 title claims abstract description 156
- 239000000645 desinfectant Substances 0.000 title claims abstract description 70
- 239000006260 foam Substances 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title abstract description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 54
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 32
- -1 perfluoroalkyl alcohol Chemical compound 0.000 claims abstract description 25
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 24
- NFDRPXJGHKJRLJ-UHFFFAOYSA-N edtmp Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O NFDRPXJGHKJRLJ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229940120146 EDTMP Drugs 0.000 claims abstract description 22
- 229940051841 polyoxyethylene ether Drugs 0.000 claims abstract description 22
- 229920000056 polyoxyethylene ether Polymers 0.000 claims abstract description 22
- ZIWRUEGECALFST-UHFFFAOYSA-M sodium 4-(4-dodecoxysulfonylphenoxy)benzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCOS(=O)(=O)c1ccc(Oc2ccc(cc2)S([O-])(=O)=O)cc1 ZIWRUEGECALFST-UHFFFAOYSA-M 0.000 claims abstract description 22
- 239000003381 stabilizer Substances 0.000 claims abstract description 18
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 15
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 15
- 239000010452 phosphate Substances 0.000 claims abstract description 15
- 239000011734 sodium Substances 0.000 claims abstract description 15
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 15
- 150000001412 amines Chemical class 0.000 claims abstract description 14
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 16
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 239000011259 mixed solution Substances 0.000 claims description 12
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 9
- 239000003085 diluting agent Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 7
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 7
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims description 5
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 5
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 5
- LVPMIMZXDYBCDF-UHFFFAOYSA-N isocinchomeronic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)N=C1 LVPMIMZXDYBCDF-UHFFFAOYSA-N 0.000 claims description 5
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 5
- GJAWHXHKYYXBSV-UHFFFAOYSA-N pyridinedicarboxylic acid Natural products OC(=O)C1=CC=CN=C1C(O)=O GJAWHXHKYYXBSV-UHFFFAOYSA-N 0.000 claims description 5
- 235000019983 sodium metaphosphate Nutrition 0.000 claims description 5
- 229960004025 sodium salicylate Drugs 0.000 claims description 5
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 5
- 239000011975 tartaric acid Substances 0.000 claims description 5
- 235000002906 tartaric acid Nutrition 0.000 claims description 5
- 239000012895 dilution Substances 0.000 claims description 4
- 238000010790 dilution Methods 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- DDAQLPYLBPPPRV-UHFFFAOYSA-N [4-(hydroxymethyl)-2-oxo-1,3,2lambda5-dioxaphosphetan-2-yl] dihydrogen phosphate Chemical compound OCC1OP(=O)(OP(O)(O)=O)O1 DDAQLPYLBPPPRV-UHFFFAOYSA-N 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 2
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 17
- 230000001954 sterilising effect Effects 0.000 abstract description 10
- 230000009471 action Effects 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract description 5
- 230000002035 prolonged effect Effects 0.000 abstract description 5
- 239000007921 spray Substances 0.000 abstract description 4
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 230000001988 toxicity Effects 0.000 abstract description 3
- 230000007613 environmental effect Effects 0.000 abstract description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 6
- 238000011049 filling Methods 0.000 description 5
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 4
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- BAERPNBPLZWCES-UHFFFAOYSA-N (2-hydroxy-1-phosphonoethyl)phosphonic acid Chemical compound OCC(P(O)(O)=O)P(O)(O)=O BAERPNBPLZWCES-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 229960004106 citric acid Drugs 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 2
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- OENLEHTYJXMVBG-UHFFFAOYSA-N pyridine;hydrate Chemical compound [OH-].C1=CC=[NH+]C=C1 OENLEHTYJXMVBG-UHFFFAOYSA-N 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/16—Foams
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a foam type peroxyacetic acid disinfectant, a preparation method and a use method thereof, wherein the foam type peroxyacetic acid disinfectant comprises the following components: 35 wt% -45 wt% of hydrogen peroxide, 30 wt% -40 wt% of acetic acid, 2 wt% -5 wt% of stabilizing agent, 1 wt% -5 wt% of phosphoric acid or sulfuric acid, and the following components: 0.1 to 0.4 weight percent of ethylenediamine tetramethylene phosphonic acid, 3 to 8 weight percent of sodium dodecyl diphenyl ether disulfonate, 0.1 to 0.5 weight percent of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, and the balance of water. The foam type peroxyacetic acid disinfectant provided by the invention has the advantages of low ecological toxicity, environmental protection, easiness in storage, long service cycle and good stability, the diluted spray liquid can maintain a foam form on the surface of an object for more than 5min, the sterilization action time of peroxyacetic acid is prolonged, the sterilization and disinfection effects are effectively ensured, and the practicability is good.
Description
Technical Field
The invention relates to the technical field of disinfectant products, in particular to a foam type peroxyacetic acid disinfectant, and a preparation method and a use method thereof.
Background
The peroxyacetic acid is a broad-spectrum and efficient disinfectant, has a chemical formula of CH3COOOH, has a relative molecular mass of 76.0518, belongs to a strong oxidant, is unstable in chemical property, and is easy to decompose when encountering large amount of heat, heavy metal ions, most of organic matters, strong alkali and the like. The peracetic acid disinfectant is environment-friendly and pollution-free, can be used for sterilizing and disinfecting medical instruments, and can be used for performing preventive disinfection in epidemic areas, isolation areas and the like.
The concentration of the peroxyacetic acid sold in the market at present is about 20%, and the stability is poor, generally ranging from 3 months to 1 year. In the prior art, the stability of the peroxyacetic acid disinfectant is improved by adding common stabilizers such as octahydroxyquinoline and the like, so that the service life is prolonged, but the octahydroxyquinoline has a carcinogenic risk and is forbidden in some countries in Europe.
In addition, the present inventors have found that when a peroxyacetic acid disinfectant is used for disinfecting surfaces of objects, particularly smooth surfaces of objects (e.g., glass, etc.), the liquid disinfectant tends to run down along the smooth surface, and the disinfecting effect is reduced because the action time with the surface to be disinfected cannot be ensured. Therefore, how to design or develop a peroxyacetic acid disinfectant with good stability and capable of ensuring the sterilization time becomes a technical problem to be solved by those skilled in the art.
Disclosure of Invention
Aiming at the defects or improvement requirements of the prior art, the invention provides a foam type peroxyacetic acid disinfectant, and a preparation method and a use method thereof.
The purpose of the invention is realized by the following technical scheme:
according to one aspect of the present invention, there is provided a foam-type peroxyacetic acid disinfectant, comprising: 35 wt% -45 wt% of hydrogen peroxide, 30 wt% -40 wt% of acetic acid, 2 wt% -5 wt% of stabilizer, 1 wt% -5 wt% of phosphoric acid or sulfuric acid, and the foam type peroxyacetic acid disinfectant further comprises: 0.1 to 0.4 weight percent of ethylenediamine tetramethylene phosphonic acid, 3 to 8 weight percent of sodium dodecyl diphenyl ether disulfonate, 0.1 to 0.5 weight percent of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, and the balance of water.
Further, the stabilizer at least comprises one of hydroxyethylidene diphosphate, disodium ethylene diamine tetraacetate, citric acid, sodium salicylate, sodium tripolyphosphate, sodium pyrophosphate, sodium metaphosphate, pyridine dicarboxylic acid and tartaric acid.
The invention also provides a foam type peroxyacetic acid disinfectant, which comprises the following components: 35 wt% -45 wt% of hydrogen peroxide, 30 wt% -40 wt% of acetic acid, 2 wt% -4 wt% of stabilizer, 1 wt% -4 wt% of phosphoric acid or sulfuric acid, and the foam type peroxyacetic acid disinfectant further comprises: 0.1 to 0.3 weight percent of ethylenediamine tetramethylene phosphonic acid, 3 to 6 weight percent of sodium dodecyl diphenyl ether disulfonate, 0.1 to 0.3 weight percent of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, and the balance of water.
According to another aspect of the present invention, there is provided a method for preparing the foam-type peroxyacetic acid disinfectant solution, comprising: adding 35-45 wt% of hydrogen peroxide, 0.1-0.4 wt% of ethylenediamine tetramethylene phosphonic acid, 2-5 wt% of stabilizer and water into a reaction kettle, controlling the temperature of the reaction kettle to be 30-40 ℃, stirring, adding 30-40 wt% of acetic acid, 1-5 wt% of phosphoric acid or sulfuric acid, 3-8 wt% of sodium dodecyl diphenyl ether disulfonate and 0.1-0.5 wt% of sodium perfluoroalkyl alcohol polyoxyethylene ether phosphate amine, stirring for 24 hours, stopping heating and stirring, standing for 24 hours, and controlling the temperature to be 20-35 ℃ to prepare the foam type peroxyacetic acid disinfectant.
According to a third aspect of the present invention, there is provided a method for using the foam-type peroxyacetic acid disinfectant: diluting the foam type peroxyacetic acid disinfectant with a diluent for use, wherein the dilution volume ratio is 1: 60-150.
Further, the diluent is water or a mixed solution of water and alcohol.
Further, the alcohol at least comprises one of ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol and 1, 3-butanediol.
Further, the volume ratio of water to alcohol in the mixed solution is 9:1-2: 3.
Compared with the prior art, the technical scheme of the invention has the following advantages:
the foam type peroxyacetic acid disinfectant provided by the invention has low ecological toxicity, is environment-friendly and is easy to store; through adding ethylenediamine tetramethylene phosphonic acid and compounding with a stabilizer, the stability of the peroxyacetic acid disinfectant system is effectively improved; the perfluoroalkyl alcohol polyoxyethylene ether amine sodium phosphate is added to stabilize the foam amount of a peroxyacetic acid disinfectant system, so that the diluted spray liquid can maintain a foam form on the surface of an object for more than 5min, the sterilization action time of the peroxyacetic acid is prolonged, the sterilization and disinfection effects are effectively ensured, and the practicability is good.
Detailed Description
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the specific embodiments. The present invention is described in further detail by the following specific embodiments, and the specific examples described in the following embodiments of the present invention are merely illustrative of the specific embodiments of the present invention and are intended to be illustrative of the present invention and are not to be construed as limiting the present invention.
The invention provides a foam type peroxyacetic acid disinfectant, which comprises the following components: 35 wt% -45 wt% of hydrogen peroxide, 30 wt% -40 wt% of acetic acid, 2 wt% -5 wt% of stabilizer, 1 wt% -5 wt% of phosphoric acid or sulfuric acid, and the foam type peroxyacetic acid disinfectant further comprises: 0.1 to 0.4 weight percent of ethylenediamine tetramethylene phosphonic acid, 3 to 8 weight percent of sodium dodecyl diphenyl ether disulfonate, 0.1 to 0.5 weight percent of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, and the balance of water.
The invention also provides a foam type peroxyacetic acid disinfectant, which comprises the following components: 35 wt% -45 wt% of hydrogen peroxide, 30 wt% -40 wt% of acetic acid, 2 wt% -4 wt% of stabilizing agent, 1 wt% -4 wt% of phosphoric acid or sulfuric acid, and the following components: 0.1 to 0.3 weight percent of ethylenediamine tetramethylene phosphonic acid, 3 to 6 weight percent of sodium dodecyl diphenyl ether disulfonate, 0.1 to 0.3 weight percent of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, and the balance of water.
Further, the stabilizer comprises one or more of hydroxyethylidene diphosphate, disodium ethylene diamine tetraacetate, citric acid, sodium salicylate, sodium tripolyphosphate, sodium pyrophosphate, sodium metaphosphate, pyridine dicarboxylic acid and tartaric acid.
In order to improve the stability of peroxyacetic acid, the invention adds the low-toxicity ethylenediamine tetramethylene phosphonic acid stabilizer, and meanwhile, the ethylenediamine tetramethylene phosphonic acid is compounded with other stabilizers, so that the overall stability of the peroxyacetic acid disinfectant system is improved. Ethylenediaminetetraacetic acid EDTMPA (ethylenediaminetetraacetic acid), molecular formula C6H12O12N2P4The solubility of the compound is poor, and the compound is only slightly soluble in water and an acid system and can be dissolved in alkali liquor. The invention adopts sodium dodecyl diphenyl ether disulfonate as a cosolvent to improve the solubility of EDTMPA, the sodium dodecyl diphenyl ether disulfonate is a surfactant, the stability of peroxyacetic acid is not damaged in a peroxyacetic acid disinfectant system, the sodium dodecyl diphenyl ether disulfonate is not easily oxidized by peroxyacetic acid, and the sodium dodecyl diphenyl ether disulfonate can coexist with peroxyacetic acid for a long time and has good applicability.
Meanwhile, in order to prolong the sterilization action time of the peroxyacetic acid and the surface to be sterilized, the invention adds perfluoroalkyl alcohol polyoxyethylene ether amine phosphate sodium capable of stabilizing the foam quantity into the peroxyacetic acid disinfectant. The perfluoroalkyl alcohol polyoxyethylene ether amine sodium phosphate belongs to a surfactant, in particular to a fluorocarbon surfactant, which can stabilize the foam amount of a peroxyacetic acid disinfectant system, does not accelerate the decomposition of peroxyacetic acid and has good applicability.
In addition, the invention provides a preparation method of the foam type peroxyacetic acid disinfectant, which comprises the following steps: firstly adding 35-45 wt% of hydrogen peroxide, 0.1-0.4 wt% of ethylene diamine tetramethylene phosphonic acid, 2-5 wt% of stabilizer and water into a reaction kettle, controlling the temperature of the reaction kettle to be 30-40 ℃, stirring, then adding 30-40 wt% of acetic acid, 1-5 wt% of phosphoric acid or sulfuric acid, 3-8 wt% of sodium dodecyl diphenyl ether disulfonate and 0.1-0.5 wt% of perfluoroalkyl alcohol polyoxyethylene ether amine phosphate sodium, stirring for 24h, stopping heating and stirring, standing for 24h, controlling the temperature to be 20-35 ℃ (the reaction is more complete, controlling the temperature of the reaction kettle to be 20-35 ℃ in the curing process), preparing the foam type peroxyacetic acid disinfectant, and filling for later use.
Furthermore, the invention provides a use method of the foam type peroxyacetic acid disinfectant, which comprises the following steps: diluting the foam type peroxyacetic acid disinfectant with a diluent for use, wherein the dilution volume ratio is 1: 60-150.
Further, the diluent is water or a mixed solution of water and alcohol.
Further, the alcohol comprises one or more of ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol and 1, 3-butanediol.
Further, the volume ratio of water to alcohol in the mixed solution is 9:1-2: 3.
Example 1:
the foam-type peroxyacetic acid disinfectant provided by the embodiment comprises: 35 wt% of hydrogen peroxide, 35 wt% of acetic acid, 0.2 wt% of ethylenediamine tetramethylene phosphonic acid, 1 wt% of phosphoric acid, 4 wt% of sodium dodecyl diphenyl ether disulfonate, 0.1 wt% of sodium perfluoroalkyl alcohol polyoxyethylene ether phosphate amine, 1 wt% of sodium salicylate, 1 wt% of sodium pyrophosphate and the balance of water.
The preparation method of the foam-type peroxyacetic acid disinfectant provided by the embodiment comprises the following steps: adding 35 wt% of hydrogen peroxide, 0.2 wt% of ethylenediamine tetramethylene phosphonic acid, 1 wt% of sodium salicylate, 1 wt% of sodium pyrophosphate and water into a reaction kettle, controlling the temperature of the reaction kettle to be 30-40 ℃, stirring, adding 35 wt% of acetic acid, 1 wt% of phosphoric acid, 4 wt% of sodium dodecyl diphenyl ether disulfonate and 0.1 wt% of perfluoroalkyl alcohol polyoxyethylene ether amine phosphate sodium, stirring for 24 hours, stopping heating and stirring, standing for 24 hours, controlling the temperature to be 20-35 ℃, preparing the foam type peroxyacetic acid disinfectant, and filling for later use.
The foam-type peroxyacetic acid disinfectant provided in example 1 was diluted with water at a volume ratio of 1:150 to prepare a diluted solution 1.
Example 2:
the foam-type peroxyacetic acid disinfectant provided by the embodiment comprises: 35 wt% of hydrogen peroxide, 40 wt% of acetic acid, 0.4 wt% of ethylenediamine tetramethylene phosphonic acid, 1 wt% of sulfuric acid, 8 wt% of sodium dodecyl diphenyl ether disulfonate, 0.5 wt% of sodium perfluoroalkyl alcohol polyoxyethylene ether phosphate amine, 1 wt% of citric acid, 2 wt% of sodium hexametaphosphate and the balance of water.
The preparation method of the foam-type peroxyacetic acid disinfectant provided by the embodiment comprises the following steps: adding 35 wt% of hydrogen peroxide, 0.4 wt% of ethylenediamine tetramethylene phosphonic acid, 1 wt% of citric acid, 2 wt% of sodium hexametaphosphate and water into a reaction kettle, controlling the temperature of the reaction kettle to be 30-40 ℃, stirring, adding 40 wt% of acetic acid, 1 wt% of sulfuric acid, 8 wt% of sodium dodecyl diphenyl ether disulfonate and 0.5 wt% of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, stirring for 24 hours, stopping heating and stirring, standing for 24 hours, controlling the temperature to be 20-35 ℃, and preparing the foam type peroxyacetic acid disinfectant, and filling for later use.
The foam-type peroxyacetic acid disinfectant provided in example 2 was diluted with a mixed solution of water and ethanol at a volume ratio of 1:150, wherein the volume ratio of water to ethanol in the mixed solution was 9:1, to prepare a diluted solution 2.
Example 3:
the foam-type peroxyacetic acid disinfectant provided by the embodiment comprises: 45 wt% of hydrogen peroxide, 40 wt% of acetic acid, 0.2 wt% of ethylenediamine tetramethylene phosphonic acid, 4 wt% of sulfuric acid, 7 wt% of sodium dodecyl diphenyl ether disulfonate, 0.4 wt% of sodium perfluoroalkyl alcohol polyoxyethylene ether phosphate amine, 3 wt% of tartaric acid, 0.2 wt% of pyridine dicarboxylic acid and the balance of water.
The preparation method of the foam-type peroxyacetic acid disinfectant provided by the embodiment comprises the following steps: firstly adding 45 wt% of hydrogen peroxide, 0.2 wt% of ethylenediamine tetramethylene phosphonic acid, 3 wt% of tartaric acid, 0.2 wt% of pyridine dicarboxylic acid and water into a reaction kettle, controlling the temperature of the reaction kettle to be 30-40 ℃, stirring, then adding 40 wt% of acetic acid, 4 wt% of sulfuric acid, 7 wt% of sodium dodecyl diphenyl ether disulfonate and 0.4 wt% of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, stirring for 24 hours, stopping heating and stirring, standing for 24 hours, controlling the temperature to be 20-35 ℃, preparing the foam type peroxyacetic acid disinfectant, and filling for later use.
The foam-type peracetic acid disinfectant provided in example 3 was diluted with a mixed solution of water and ethylene glycol at a volume ratio of 1:100, wherein the volume ratio of water to ethylene glycol in the mixed solution was 8:1, to prepare a diluted solution 3.
Example 4:
the foam-type peroxyacetic acid disinfectant provided by the embodiment comprises: 45 wt% of hydrogen peroxide, 40 wt% of acetic acid, 0.3 wt% of ethylene diamine tetra methylene phosphonic acid, 1 wt% of sulfuric acid, 8 wt% of sodium dodecyl diphenyl ether disulfonate, 0.3 wt% of perfluoroalkyl alcohol polyoxyethylene ether amine phosphate sodium, 0.5 wt% of hydroxyethylidene diphosphonic acid, 0.1 wt% of disodium ethylene diamine tetraacetate, 0.5 wt% of sodium tripolyphosphate, 0.5 wt% of sodium pyrophosphate, 0.2 wt% of sodium metaphosphate and the balance of water.
The preparation method of the foam-type peroxyacetic acid disinfectant provided by the embodiment comprises the following steps: firstly adding 45 wt% of hydrogen peroxide, 0.3 wt% of ethylenediamine tetramethylene phosphonic acid, 0.5 wt% of hydroxyethylidene diphosphonic acid, 0.1 wt% of disodium ethylenediamine tetraacetic acid, 0.5 wt% of sodium tripolyphosphate, 0.5 wt% of sodium pyrophosphate, 0.2 wt% of sodium metaphosphate and water into a reaction kettle, controlling the temperature of the reaction kettle to be 30-40 ℃, stirring, adding 40 wt% of acetic acid, 1 wt% of sulfuric acid, 8 wt% of sodium dodecyl diphenyl ether disulfonate and 0.3 wt% of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, stirring for 24 hours, stopping heating and stirring, standing for 24 hours, controlling the temperature to be 20-35 ℃, preparing the foam type peroxyacetic acid disinfectant, and filling for later use.
The foam-type peracetic acid disinfectant provided in example 4 was diluted with a mixed solution of water and 1, 3-butanediol at a volume ratio of 1:90, wherein the volume ratio of water to 1, 3-butanediol in the mixed solution was 7:1, to prepare a diluted solution 4.
The foam-type peroxyacetic acid disinfectant provided by the above examples 1, 2, 3 and 4 was placed in an oven at 54 ℃ for 14 days, and the reduction rates of the bactericidal active ingredients in the disinfectant were respectively determined as follows: 6.25 percent, 5.43 percent, 7.13 percent and 6.02 percent, the reduction rate of the sterilization active ingredients is less than or equal to 10 percent, the stability is good, and the product meets the qualification standard (within 10 percent of the reduction rate of the sterilization active ingredients) of the stability acceleration test in the 'Disinfection technical Specification 2002 edition'.
The above dilutions 1, 2, 3 and 4 were subjected to a microbe killing experiment according to "2002 edition of disinfection specifications", and the experimental results are shown in the following table:
the experimental data in the table show that the foam type peroxyacetic acid disinfectant provided by the invention has a killing effect on three microorganisms in the table under low concentration after being diluted, and the sterilization effect is stable.
When in use, the diluent 1-4 can be filled into a sprayer (such as a daily disinfection sprayer with a pressurizing function) to spray and disinfect the surface of an object, the sprayed liquid can maintain a foam form on the surface of the object for more than 5min, the sterilization action time of peracetic acid is prolonged, and the sterilization and disinfection effects are effectively ensured.
In conclusion, the foam type peroxyacetic acid disinfectant provided by the invention has the advantages of low ecological toxicity, environmental protection, easiness in storage and long service cycle; through adding ethylenediamine tetramethylene phosphonic acid and compounding with a stabilizer, the stability of a peroxyacetic acid disinfectant system is effectively improved, and the stability is good; the perfluoroalkyl alcohol polyoxyethylene ether amine sodium phosphate is added to stabilize the foam amount of a peroxyacetic acid disinfectant system, so that the diluted spray liquid can maintain a foam form on the surface of an object for more than 5min, the sterilization action time of the peroxyacetic acid is prolonged, the sterilization and disinfection effects are effectively ensured, and the practicability is good.
It should be noted that the above-mentioned embodiments illustrate rather than limit the invention, and that those skilled in the art will be able to design alternative embodiments without departing from the scope of the appended claims. The present embodiments are therefore to be considered as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein, and any reference signs in the claims are not intended to be construed as limiting the claim concerned. In the claims, the word "comprising" does not exclude the presence of data or steps not listed in a claim.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (8)
1. A foam-type peroxyacetic acid disinfectant comprises: 35 wt% -45 wt% of hydrogen peroxide, 30 wt% -40 wt% of acetic acid, 2 wt% -5 wt% of stabilizer and 1 wt% -5 wt% of phosphoric acid or sulfuric acid, and is characterized in that the foam type peroxyacetic acid disinfectant also comprises: 0.1 to 0.4 weight percent of ethylenediamine tetramethylene phosphonic acid, 3 to 8 weight percent of sodium dodecyl diphenyl ether disulfonate, 0.1 to 0.5 weight percent of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, and the balance of water.
2. The foam-type peroxyacetic acid disinfectant as set forth in claim 1, wherein: the stabilizer at least comprises one of hydroxyethylidene diphosphate, ethylene diamine tetraacetic acid disodium, citric acid, sodium salicylate, sodium tripolyphosphate, sodium pyrophosphate, sodium metaphosphate, pyridine dicarboxylic acid and tartaric acid.
3. A foam-type peroxyacetic acid disinfectant comprises: 35 wt% -45 wt% of hydrogen peroxide, 30 wt% -40 wt% of acetic acid, 2 wt% -4 wt% of stabilizer and 1 wt% -4 wt% of phosphoric acid or sulfuric acid, and is characterized in that the foam type peroxyacetic acid disinfectant also comprises: 0.1 to 0.3 weight percent of ethylenediamine tetramethylene phosphonic acid, 3 to 6 weight percent of sodium dodecyl diphenyl ether disulfonate, 0.1 to 0.3 weight percent of perfluoroalkyl alcohol polyoxyethylene ether phosphate amine sodium, and the balance of water.
4. The process for producing a foam-type peroxyacetic acid disinfectant solution according to any one of claims 1 to 2, wherein: adding 35-45 wt% of hydrogen peroxide, 0.1-0.4 wt% of ethylenediamine tetramethylene phosphonic acid, 2-5 wt% of stabilizer and water into a reaction kettle, controlling the temperature of the reaction kettle to be 30-40 ℃, stirring, adding 30-40 wt% of acetic acid, 1-5 wt% of phosphoric acid or sulfuric acid, 3-8 wt% of sodium dodecyl diphenyl ether disulfonate and 0.1-0.5 wt% of sodium perfluoroalkyl alcohol polyoxyethylene ether phosphate amine, stirring for 24 hours, stopping heating and stirring, standing for 24 hours, and controlling the temperature to be 20-35 ℃ to prepare the foam type peroxyacetic acid disinfectant.
5. The method of using the foam-type peracetic acid disinfectant as set forth in any one of claims 1 to 3, wherein: diluting the foam type peroxyacetic acid disinfectant with a diluent for use, wherein the dilution volume ratio is 1: 60-150.
6. The method of using a foam-type peroxyacetic acid disinfectant as claimed in claim 5, wherein: the diluent is water or a mixed solution of water and alcohol.
7. The method of using a foam-type peroxyacetic acid disinfectant as claimed in claim 6, wherein: the alcohol at least comprises one of ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol and 1, 3-butanediol.
8. The method of using a foam-type peroxyacetic acid disinfectant as claimed in claim 7, wherein: the volume ratio of water to alcohol in the mixed solution is 9:1-2: 3.
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