CN118320000A - Traditional Chinese medicine composition with detoxifying and blood cooling effects, detoxifying and blood cooling mixture as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with detoxifying and blood cooling effects, detoxifying and blood cooling mixture as well as preparation method and application thereof Download PDFInfo
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- CN118320000A CN118320000A CN202410392549.3A CN202410392549A CN118320000A CN 118320000 A CN118320000 A CN 118320000A CN 202410392549 A CN202410392549 A CN 202410392549A CN 118320000 A CN118320000 A CN 118320000A
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- traditional chinese
- blood
- chinese medicine
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with detoxifying and blood cooling effects, a detoxifying and blood cooling mixture, and a preparation method and application thereof. The traditional Chinese medicine composition takes dyers woad leaf, radix isatidis and bunge corydalis herb as monarch drugs, plays the roles of detoxification and cooling blood, takes radix scutellariae, honeysuckle, fructus forsythiae, lithospermum, schizonepeta and radix angelicae as ministerial drugs for dispelling wind and clearing heat, takes radix scrophulariae, sanguisorba, wild chrysanthemum and radix paeoniae rubra as ministerial drugs, and takes liquorice as messenger to harmonize the drug properties, and finally achieves the effect of treating acne. According to the specific embodiment, the traditional Chinese medicine composition can effectively treat acne, and the treatment course is short; meanwhile, the traditional Chinese medicine composition is a common traditional Chinese medicine, and has very little side effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with detoxifying and blood cooling effects, a detoxifying and blood cooling mixture, and a preparation method and application thereof.
Background
Acne, also known as comedo, is a chronic inflammatory skin condition that occurs well in puberty and primarily involves the pilosebaceous glands of the face. Meanwhile, acne is the most common skin chronic inflammatory disease in the world, and is often caused at the position with vigorous sebum secretion of hair follicles, and the quality of life of many people is influenced by large-area skin lesions. At present, the pathogenesis of acne is not completely elucidated, for example, hormone-induced sebaceous gland transitional bleeding lipid, abnormal keratosis of a pilosebaceous canal, abnormal proliferation of hair follicle microorganisms such as propionibacterium acnes and staphylococcus epidermidis, inflammation, immune response and the like can be related to the pathogenesis of acne. Acne is frequently found in puberty, but not puberty, and is often found in sebaceous gland-rich parts such as face, back and chest, and is classified clinically according to skin loss properties in a three-degree four-level manner, namely: mild (grade i): only acne, manifested by open comedones (blackheads), closed comedones (whiteheads); moderate (grade ii): inflammatory papules; moderate (grade iii): pustules appear; severe (grade iv): has tubercles and cysts. Inflammatory papules, pustules, and abscesses may cause severe pigmentation and even scarring after healing.
At present, the acne is mostly treated by antibacterial drugs. However, the long-term use of antimicrobial drugs has serious effects on skin micro-ecology, such as damage to cell integrity, and hair follicle damage. Therefore, it is necessary to find a medicament for treating acne which has a short course of treatment, is effective and has no toxic or adverse effects.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition with the effects of detoxifying and cooling blood, a detoxifying and cooling blood mixture, and a preparation method and application thereof, so as to solve the problems in the prior art. The traditional Chinese medicine composition can effectively treat acne, and the treatment course is short; meanwhile, the traditional Chinese medicine composition is a common traditional Chinese medicine, and has very little side effect.
In order to achieve the above object, the present invention provides the following solutions:
The invention provides a traditional Chinese medicine composition with the effects of detoxifying and cooling blood, which comprises the following components in parts by mass:
15-20 parts of radix scutellariae, 20-30 parts of dyers woad leaf, 15-20 parts of radix isatidis, 25-30 parts of honeysuckle, 10-15 parts of radix scrophulariae, 10-15 parts of garden burnet, 25-35 parts of herba violae, 20-30 parts of fructus forsythiae, 20-30 parts of lithospermum, 15-25 parts of wild chrysanthemum, 15-20 parts of radix paeoniae rubra, 10-15 parts of liquorice, 20-25 parts of herba schizonepetae and 10-15 parts of radix angelicae.
Further preferably, the scutellaria baicalensis has the effects of clearing heat, drying dampness and purging fire for detoxification; the folium Isatidis has effects of clearing heat and detoxicating, cooling blood and resolving macula; the radix Isatidis has effects of clearing heat and detoxicating, cooling blood and relieving sore throat; the flos Lonicerae has effects of clearing heat, detoxicating and dispelling pathogenic wind and heat; the radix scrophulariae has effects of clearing heat and cooling blood, purging pathogenic fire and removing toxic substances, and nourishing yin; the radix Sanguisorbae has effects of cooling blood, stopping bleeding, removing toxic substances, and healing sore; the herba Violae has effects of clearing heat and toxic materials and eliminating carbuncle; the fructus forsythiae has effects of clearing heat and detoxicating, detumescence and resolving hard mass, and dispelling wind and heat; the radix Arnebiae has effects of clearing heat, cooling blood, promoting blood circulation, removing toxic substances, and promoting eruption; the flos Chrysanthemi Indici has effects of clearing heat and detoxicating; the radix Paeoniae Rubra has effects of clearing heat, cooling blood, promoting blood circulation, and removing blood stasis; the licorice has the effects of tonifying qi, strengthening the middle warmer, moistening lung, relieving cough, clearing heat, detoxicating, relieving spasm, relieving pain and harmonizing medicine property; the herba Schizonepetae has effects of dispelling pathogenic wind, relieving exterior syndrome, promoting eruption, eliminating sore and stopping bleeding; the radix Angelicae Dahuricae has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, relieving stuffy nose, eliminating dampness, relieving leukorrhagia, detumescence, expelling pus, dispelling pathogenic wind, and relieving itching.
The invention provides application of the traditional Chinese medicine composition in preparing a detoxifying and blood cooling mixture.
The invention provides a detoxification and blood cooling mixture, which is prepared from the following raw materials of 15-20 parts of radix scutellariae, 20-30 parts of dyers woad leaf, 15-20 parts of radix isatidis, 25-30 parts of honeysuckle, 10-15 parts of radix scrophulariae, 10-15 parts of garden burnet root, 25-35 parts of herba violae, 20-30 parts of fructus forsythiae, 20-30 parts of lithospermum, 15-25 parts of wild chrysanthemum flower, 15-20 parts of red paeony root, 10-15 parts of liquorice, 20-25 parts of herba schizonepetae, 10-15 parts of radix angelicae, 25-30 parts of sucrose, 1-2 parts of potassium sorbate and 1-2 parts of borneol.
The invention provides a preparation method of the detoxification and blood cooling mixture, which comprises the following steps:
Mixing Scutellariae radix, herba corydalis Bungeanae, fructus forsythiae, radix Arnebiae, flos Chrysanthemi Indici, radix Paeoniae Rubra, glycyrrhrizae radix, herba Schizonepetae and radix Angelicae Dahuricae, and performing first water extraction to obtain residue and first filtrate; carrying out second water extraction on the filter residues to obtain second filtrate; combining the first filtrate and the second filtrate to obtain an aqueous extract;
Concentrating the water extract, precipitating with ethanol, filtering, collecting filtrate, and removing ethanol to obtain fluid extract;
Mixing folium Isatidis, radix Isatidis, flos Lonicerae, radix scrophulariae and radix Sangusorbae with water, and performing synergistic fermentation with bacteria and enzymes to obtain fermentation broth;
mixing the extract fermentation liquor, sucrose, potassium sorbate and borneol to obtain the detoxifying and blood cooling mixture.
Preferably, when the bacterial enzymes are used for synergistic fermentation, the adopted composite enzyme preparation comprises xylanase, cellulase, laccase and alkaline protease; the adopted composite microbial inoculum comprises bacillus licheniformis, bacillus coagulans and lactococcus lactis.
Preferably, the dosage of the compound enzyme preparation is 0.5-1% of the total mass of dyers woad leaf, radix isatidis, honeysuckle, radix scrophulariae and garden burnet;
The dosage of the compound bacteria is 1-3% of the total mass of the dyers woad leaf, the radix isatidis, the honeysuckle, the radix scrophulariae and the sanguisorbae.
Preferably, the time of the synergistic fermentation of the bacterial enzymes is 24-72 hours, and the temperature is 30-40 ℃.
Preferably, in the first water extraction, the mass ratio of the total mass of the baikal skullcap root, the bunge corydalis herb, the weeping forsythia capsule, the lithospermum, the wild chrysanthemum flower, the red paeony root, the liquorice, the schizonepeta and the angelica dahurica to the water is 1:8-12, the time is 1-2h.
Preferably, in the second water extraction, the mass ratio of the filter residue to water is 1:8-10, and the time is 1.5-2h.
The invention provides an application of the traditional Chinese medicine composition or the detoxification and blood cooling mixture in preparing a medicine for treating acne.
The invention discloses the following technical effects:
The invention provides a traditional Chinese medicine composition with the effects of detoxifying and cooling blood, which takes dyers woad leaf, isatis root and bunge corydalis herb as principal drugs, plays the roles of detoxifying and cooling blood, takes baikal skullcap root, honeysuckle flower, weeping forsythiae capsule, lithospermum, schizonepeta and dahurian angelica root as ministerial drugs for dispelling wind and clearing heat, takes figwort root, garden burnet root, wild chrysanthemum flower and red paeony root as ministerial drugs, and takes liquorice as messenger to regulate drug properties, thus finally realizing the effect of treating acne. According to the specific embodiment, the traditional Chinese medicine composition can effectively treat acne, and the treatment course is short; meanwhile, the traditional Chinese medicine composition is a common traditional Chinese medicine, and has very little side effect.
The invention also provides a preparation method of the detoxification and blood cooling mixture, in the preparation method, different traditional Chinese medicinal materials adopt different extraction modes, so that the effective components in the prepared detoxification and blood cooling mixture are increased, and the optimal effect of the traditional Chinese medicinal materials is finally exerted. And the method has the advantages of simplicity and low cost.
Detailed Description
Various exemplary embodiments of the invention will now be described in detail, which should not be considered as limiting the invention, but rather as more detailed descriptions of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. In addition, for numerical ranges in this disclosure, it is understood that each intermediate value between the upper and lower limits of the ranges is also specifically disclosed. Every smaller range between any stated value or stated range, and any other stated value or intermediate value within the stated range, is also encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the invention described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from consideration of the specification of the present invention. The specification and examples of the present invention are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are intended to be inclusive and mean an inclusion, but not limited to.
Example 1
A detoxification and blood cooling mixture is prepared from the following raw materials in parts by mass: 20 parts of radix scutellariae, 30 parts of dyers woad leaf, 20 parts of radix isatidis, 25 parts of honeysuckle, 10 parts of radix scrophulariae, 15 parts of garden burnet, 25 parts of herba violae, 25 parts of fructus forsythiae, 23 parts of lithospermum, 20 parts of wild chrysanthemum flower, 17 parts of red paeony root, 12 parts of liquorice, 23 parts of herba schizonepetae, 15 parts of radix angelicae, 30 parts of sucrose, 1 part of potassium sorbate and 1 part of borneol.
The preparation method specifically comprises the following steps:
Step 1: mixing radix Scutellariae, herba Violae, fructus forsythiae, radix Arnebiae, flos Chrysanthemi Indici, radix Paeoniae Rubra, radix Glycyrrhizae, herba Schizonepetae and radix Angelicae Dahuricae, extracting with water for 1.5 hr at a ratio of 1:10 (total mass of radix Scutellariae, herba Violae, fructus forsythiae, radix Arnebiae, flos Chrysanthemi Indici, radix Paeoniae Rubra, radix Glycyrrhizae, herba Schizonepetae and radix Angelicae Dahuricae to water ratio of 1:10), filtering to obtain residue and filtrate; carrying out second water extraction on the obtained filter residue, wherein the feed-liquid ratio is 1:9 (the mass ratio of the filter residue to water is 1:9), and filtering to obtain filter residue and filtrate; combining the two filtrates to obtain an aqueous extract;
Step 2: concentrating the water extract until the relative density of the obtained concentrated solution reaches 1.12 (measured at 50 ℃), stopping concentrating, adding 95% ethanol water solution for alcohol precipitation for 48h, filtering to obtain filtrate, and recovering ethanol in the filtrate to obtain extract;
step 3: mixing folium Isatidis, radix Isatidis, flos Lonicerae, radix scrophulariae and radix Sangusorbae with water at a mass ratio of 1:2 (total mass of folium Isatidis, radix Isatidis, flos Lonicerae, radix scrophulariae and radix Sangusorbae and water mass ratio of 1:2), and performing bacteria and enzyme synergistic fermentation to obtain fermentation broth; the composite enzyme preparation adopted by the synergistic fermentation of the bacterial enzymes comprises xylitol enzyme, cellulase, laccase and alkaline protease, wherein the enzyme activity of the xylitol enzyme in the composite enzyme preparation is 10000U/g, the enzyme activity of the cellulase is 20000U/g, the enzyme activity of the laccase is 7000U/g, the enzyme activity of the alkaline protease is 10000U/g, and the addition amount of the composite enzyme preparation is 1% of the total mass of dyers woad leaf, radix isatidis, honeysuckle, radix scrophulariae and garden burnet; the composite microbial inoculum adopted by the synergistic fermentation of the microbial enzymes consists of bacillus licheniformis, bacillus coagulans and lactococcus lactis, wherein the effective viable count of the bacillus licheniformis, the bacillus coagulans and the lactococcus lactis in the composite microbial inoculum is 1:1:2, namely the effective viable count of the bacillus licheniformis, the bacillus coagulans and the lactococcus lactis in the composite microbial inoculum is 1X 10 8CFU/g、1×108 CFU/g and 2X 10 8 CFU/g respectively, and the addition amount of the composite microbial inoculum is 2% of the total mass of dyers woad leaf, radix isatidis, honeysuckle, radix scrophulariae and sanguisorba officinalis; the time of the synergistic fermentation of the bacterial enzymes is 36 hours, and the temperature is 35 ℃;
mixing the extract, fermentation liquor, sucrose, potassium sorbate and borneol uniformly to obtain the mixture for removing toxic substances and cooling blood.
Example 2
The same raw materials and the preparation method as in example 1 are different only in the use amount of the raw materials and the feed liquid ratio in the preparation process, and specifically:
The raw materials are different in dosage: 18 parts of radix scutellariae, 25 parts of dyers woad leaf, 17 parts of radix isatidis, 29 parts of honeysuckle, 15 parts of radix scrophulariae, 10 parts of sanguisorba officinalis, 35 parts of herba violae, 20 parts of fructus forsythiae, 20 parts of lithospermum, 15 parts of wild chrysanthemum flower, 20 parts of radix paeoniae rubra, 10 parts of liquorice, 20 parts of herba schizonepetae, 13 parts of radix angelicae, 28 parts of sucrose, 2 parts of potassium sorbate and 1.5 parts of borneol.
The feed liquid ratio is different: in the step 1, the mass ratio of the total mass of the baical skullcap root, the bunge corydalis herb, the weeping forsythiae capsule, the lithospermum, the wild chrysanthemum flower, the red paeony root, the liquoric root, the fineleaf schizonepeta herb and the dahurian angelica root to the water is 1:8, 8; the mass ratio of filter residue to water is 1:10.
Example 3
The same raw materials and the preparation method as in example 1 are different only in the use amount of the raw materials and the feed liquid ratio in the preparation process, and specifically:
The raw materials are different in dosage: 15 parts of radix scutellariae, 20 parts of dyers woad leaf, 15 parts of radix isatidis, 30 parts of honeysuckle, 13 parts of radix scrophulariae, 12 parts of garden burnet, 27 parts of herba violae, 29 parts of fructus forsythiae, 30 parts of lithospermum, 25 parts of wild chrysanthemum flower, 15 parts of red paeony root, 15 parts of liquorice, 25 parts of herba schizonepetae, 10 parts of radix angelicae, 25 parts of sucrose, 1.5 parts of potassium sorbate and 2 parts of borneol.
The feed liquid ratio is different: in the step 1, the mass ratio of the total mass of the baical skullcap root, the bunge corydalis herb, the weeping forsythiae capsule, the lithospermum, the wild chrysanthemum flower, the red paeony root, the liquoric root, the fineleaf schizonepeta herb and the dahurian angelica root to the water is 1:12; the mass ratio of filter residue to water is 1:10.
Example 4
The same materials and components as in example 1 were prepared, with the only differences: in the process of the synergistic fermentation of the bacterial enzymes, the dosage of the compound enzyme preparation is 0.8 percent of the total mass of the dyers woad leaf, the dyer woad root, the honeysuckle, the figwort root and the garden burnet root.
Example 5
The same materials and components as in example 1 were prepared, with the only differences: in the process of the synergistic fermentation of the bacterial enzymes, the dosage of the compound bacterial agent is 3 percent of the total mass of the dyers woad leaf, the dyer woad root, the honeysuckle, the figwort root and the garden burnet root.
Comparative example 1
The procedure was identical to that of example 1, except that the starting materials were different, in particular:
20 parts of radix scutellariae, 30 parts of mint, 20 parts of dandelion, 25 parts of honeysuckle, 10 parts of radix scrophulariae, 15 parts of garden burnet, 25 parts of herba violae, 25 parts of fructus forsythiae, 23 parts of lithospermum, 20 parts of wild chrysanthemum flower, 17 parts of red paeony root, 12 parts of liquorice, 23 parts of herba schizonepetae, 15 parts of radix angelicae, 30 parts of sucrose, 1 part of potassium sorbate and 1 part of borneol.
Comparative example 2
The procedure was identical to that of example 1, except that the starting materials were different, in particular:
20 parts of radix scutellariae, 20 parts of radix isatidis, 25 parts of honeysuckle, 10 parts of radix scrophulariae, 15 parts of garden burnet, 25 parts of herba violae, 25 parts of fructus forsythiae, 23 parts of lithospermum, 20 parts of wild chrysanthemum flower, 17 parts of red paeony root, 12 parts of liquorice, 23 parts of herba schizonepetae, 15 parts of radix angelicae, 30 parts of sucrose, 1 part of potassium sorbate and 1 part of borneol.
Comparative example 3
The same materials and components as in example 1 were prepared, with the only differences: the complex enzyme preparation adopted by the synergistic fermentation of the bacterial enzymes comprises hemicellulase, cellulase, laccase and alkaline protease, wherein the enzyme activity of the hemicellulase in the complex enzyme preparation is 10000U/g, the enzyme activity of the cellulase is 20000U/g, the enzyme activity of the laccase is 7000U/g, and the enzyme activity of the alkaline protease is 10000U/g.
Comparative example 4
The same materials and components as in example 1 were prepared, with the only differences: the composite microbial inoculum adopted by the synergistic fermentation of the microbial enzymes consists of bacillus licheniformis, bacillus subtilis and lactococcus lactis, wherein the effective viable count of the bacillus licheniformis, the bacillus subtilis and the lactococcus lactis in the composite microbial inoculum is 1:1:2, namely the effective viable count of the bacillus licheniformis, the bacillus subtilis and the lactococcus lactis in the composite microbial inoculum is 1X 10 8CFU/g、1×108 CFU/g and 2X 10 8 CFU/g respectively.
Comparative example 5
The preparation method is as follows, which has the same raw materials and components as in example 1:
Mixing radix Scutellariae, folium Isatidis, radix Isatidis, flos Lonicerae, radix scrophulariae, radix Sangusorbae, herba Violae, fructus forsythiae, radix Arnebiae, flos Chrysanthemi Indici, radix Paeoniae Rubra, radix Glycyrrhrizae, herba Schizonepetae and radix Angelicae Dahuricae, performing first water extraction with a feed-liquid ratio of 1:10 (the total mass of radix Scutellariae, folium Isatidis, radix Isatidis, flos Lonicerae, radix scrophulariae, radix Sangusorbae, herba Violae, fructus forsythiae, radix Arnebiae, flos Chrysanthemi Indici, radix Paeoniae Rubra, radix Glycyrrhrizae, herba Schizonepetae and radix Angelicae Dahuricae and water ratio of 1:10), filtering for 1.5 hr to obtain filter residue and filtrate; carrying out second water extraction on the obtained filter residue, wherein the feed-liquid ratio is 1:9 (the mass ratio of the filter residue to water is 1:9), and filtering to obtain filter residue and filtrate; combining the two filtrates to obtain an aqueous extract;
Concentrating the water extract until the relative density of the obtained concentrated solution reaches 1.12 (measured at 50 ℃), stopping concentrating, adding 95% ethanol water solution for alcohol precipitation for 48h, filtering to obtain filtrate, and recovering ethanol in the filtrate to obtain extract;
taking 110mL of purified water, boiling, adding sucrose, stirring to dissolve, continuously heating to 100 ℃, filtering (200-mesh filter cloth), adding a proper amount of hot water, and cooling to room temperature to 250mL to obtain single syrup;
Mixing the extract, simple syrup, potassium sorbate and Borneolum Syntheticum to obtain the mixture for removing toxic substances and cooling blood.
Experimental example 1 toxicity experiment
Test animals: 110 Kunming mice, about 50g in weight, about 10 male and female animals treated in examples 1-5 and comparative examples 1-5 respectively, were subjected to 2 mL/day of gavage, and had no obvious toxic or side effects on animals before and after administration by using distilled water of the same volume as the control group, and the animals were not dead or abnormally represented by continuous observation for 14 days. The test results show that: the detoxification and blood cooling mixture of examples 1-5 and comparative examples 1-5 has no obvious toxicity to experimental animals, which suggests that the detoxification and blood cooling mixture of examples 1-5 and comparative examples 1-5 is safe for clinical application.
Experimental example 2 clinical experiments
In order to prove the curative effect of the detoxification and blood cooling mixture provided by the invention, 420 subjects are tested, and the specific steps are as follows:
1. acne patients incorporate labels:
The rich sebaceous glands such as facial and upper trunk parts include acne, folliculitis papules, pustules, nodules, etc.
2. Reject criteria:
Patients suffering from mental disorders; women in lactation or gestation; patients who did not cooperate with treatment or who were abandoned halfway.
3. Acne patient:
The ages between 18 and 30 are consistent with inclusion marks.
4. Grouping:
The experimental groupings are shown in table 1:
TABLE 1 grouping case
5. Standard of efficacy:
(1) And (3) healing: the affected part skin is completely recovered, and has no difference compared with the surrounding healthy skin. The skin surface is smooth, and the secretion of sebaceous glands is obviously reduced.
(2) The method is effective: compared with the prior treatment, the acne, pustule, nodule and papule on the affected part skin surface are obviously reduced and relieved, and the pustule and papule on the focus part are obviously reduced. After partial healing, there remains significant pigmentation or pits, hypertrophic scars and crab foot swelling.
(3) Invalidation: the affected skin lesions are not relieved or aggravated compared with those before treatment, or recur after healing.
After four weeks, counting the number of healed patients, the number of effective patients, the number of ineffective patients and the total effective rate, wherein the calculation formula of the total effective rate is total effective rate= (healed patients + effective patients)/total number of patients multiplied by 100%; the number of recurrent persons was counted in a follow-up visit after half a year, the recurrent rate was calculated, the calculation formula was recurrent rate=recurrent persons/(healed persons+effective persons) ×100%, and the investigation results are shown in table 2.
TABLE 2 therapeutic effects
As can be seen from Table 2, the detoxification and blood cooling mixture prepared by adopting the examples 1-5 of the invention can remarkably improve the total effective rate and reduce the recurrence rate. The medicine has obvious advantages compared with positive medicines (tetracycline tablet).
From the above, the detoxification and blood cooling mixture prepared in examples 1-5 provided by the invention can effectively treat acne without toxic or side effects.
The above embodiments are only illustrative of the preferred embodiments of the present invention and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art to the technical solutions of the present invention should fall within the protection scope defined by the claims of the present invention without departing from the design spirit of the present invention.
Claims (10)
1. The traditional Chinese medicine composition with the effects of detoxifying and cooling blood is characterized by comprising the following components in parts by mass:
15-20 parts of radix scutellariae, 20-30 parts of dyers woad leaf, 15-20 parts of radix isatidis, 25-30 parts of honeysuckle, 10-15 parts of radix scrophulariae, 10-15 parts of garden burnet, 25-35 parts of herba violae, 20-30 parts of fructus forsythiae, 20-30 parts of lithospermum, 15-25 parts of wild chrysanthemum, 15-20 parts of radix paeoniae rubra, 10-15 parts of liquorice, 20-25 parts of herba schizonepetae and 10-15 parts of radix angelicae.
2. The use of the Chinese medicinal composition according to claim 1 in preparing a mixture for removing toxic substances and cooling blood.
3. The preparation raw materials of the detoxification and blood cooling mixture are 15-20 parts of radix scutellariae, 20-30 parts of dyers woad leaf, 15-20 parts of radix isatidis, 25-30 parts of honeysuckle, 10-15 parts of radix scrophulariae, 10-15 parts of garden burnet, 25-35 parts of herba violae, 20-30 parts of fructus forsythiae, 20-30 parts of lithospermum, 15-25 parts of wild chrysanthemum, 15-20 parts of radix paeoniae rubra, 10-15 parts of liquorice, 20-25 parts of schizonepeta, 10-15 parts of radix angelicae, 25-30 parts of sucrose, 1-2 parts of potassium sorbate and 1-2 parts of borneol.
4. A method for preparing the detoxification and blood cooling mixture as claimed in claim 3, comprising the following steps:
Mixing Scutellariae radix, herba corydalis Bungeanae, fructus forsythiae, radix Arnebiae, flos Chrysanthemi Indici, radix Paeoniae Rubra, glycyrrhrizae radix, herba Schizonepetae and radix Angelicae Dahuricae, and performing first water extraction to obtain residue and first filtrate; carrying out second water extraction on the filter residues to obtain second filtrate; combining the first filtrate and the second filtrate to obtain an aqueous extract;
concentrating, precipitating with ethanol, filtering, collecting filtrate, and removing ethanol to obtain fluid extract;
Mixing folium Isatidis, radix Isatidis, flos Lonicerae, radix scrophulariae and radix Sangusorbae with water, and performing synergistic fermentation with bacteria and enzymes to obtain fermentation broth;
Mixing the fluid extract, the fermentation liquor, the sucrose, the potassium sorbate and the borneol to obtain the detoxification and blood cooling mixture.
5. The method according to claim 4, wherein the complex enzyme preparation used in the synergistic fermentation of the bacterial enzymes comprises xylanase, cellulase, laccase and alkaline protease; the adopted composite microbial inoculum comprises bacillus licheniformis, bacillus coagulans and lactococcus lactis.
6. The preparation method according to claim 5, wherein the dosage of the complex enzyme preparation is 0.5-1% of the total mass of dyers woad leaf, radix isatidis, honeysuckle, radix scrophulariae and sanguisorba officinalis;
The dosage of the compound bacteria is 1-3% of the total mass of the dyers woad leaf, the radix isatidis, the honeysuckle, the radix scrophulariae and the sanguisorbae.
7. The method according to claim 4 or 5, wherein the bacterial enzyme is co-fermented for 24-72 hours at 30-40 ℃.
8. The preparation method according to claim 4, wherein the ratio of the total mass of the baikal skullcap root, the bunge corydalis herb, the weeping forsythia capsule, the lithospermum, the wild chrysanthemum flower, the red paeony root, the liquorice, the schizonepeta herb and the dahurian angelica root to the mass of the water is 1 when the first water extraction is carried out: 8-12, the time is 1-2h.
9. The method according to claim 4, wherein the mass ratio of the filter residue to water is 1:8-10, and the time is 1.5-2h.
10. The use of the Chinese medicinal composition of claim 1 or the detoxication and blood cooling mixture of claim 3 in the preparation of a medicament for treating acne.
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| CN202410392549.3A CN118320000A (en) | 2024-04-02 | 2024-04-02 | Traditional Chinese medicine composition with detoxifying and blood cooling effects, detoxifying and blood cooling mixture as well as preparation method and application thereof |
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