CN104740583B - It is a kind of to be used to alleviate Chinese medicine preparation of Crohn disease and preparation method thereof - Google Patents
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Abstract
The invention discloses a kind of Chinese medicine preparations for alleviating Crohn disease, it is made of dark plum, Schisandra chinensis, asarum, rhizoma zingiberis, the coptis, Cortex Phellodendri, bletilla, Radix Notoginseng powder, monkshood, Radix Angelicae Sinensis, Chinese cassia tree, red ginseng, Chinese prickly ash, radix bupleuri, cassia twig, Radix Paeoniae Alba, evodia rutaecarpa, nutmeg, psoralea corylifolia, Semen Coicis Semen Coicis, Poria cocos, jujube, honey-fried licorice root according to certain weight proportion, have effects that relieving diarrhea with astringents, expelling pus and promoting granulation, nourishing generate fluid, heat-clearing and damp-drying drug, the symptom of Crohn disease can be effectively relieved, reduce complication, mitigate patient's pain, and then achievees the purpose that treatment.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparations, and in particular to a kind of Chinese medicine preparation for alleviating Crohn disease.The present invention
Further relate to the preparation method of the Chinese medicine preparation.
Background technology
Crohn disease (crohndisease, CD), also known as regional enteritis, regional enteritis, segmental enteritis and meat
The swollen property enteritis of bud, is a kind of bowl inflammatory diseases that reason is unknown.Both this disease and chronic nonspecific ulcerative colitis
It is referred to as inflammatory bowel disease (IBD).The cause of disease of Crohn disease is not yet bright, may be the comprehensive function of a variety of pathogenic factors, and exempt from
Epidemic disease is abnormal, infect and inherent cause is like more related.Crohn disease is through the proliferative lesion of each layer of intestinal wall, and invades mesenterium
And regional nodes.Lesion is confined to small intestine (predominantly terminal ileum) and colon person respectively accounts for 30%, and the two is involved simultaneously respectively to be accounted for
40%, it is often ileum and right hemicolon lesion.Crohn by pathological change be divided into acute inflammation stage, ulcer formed the phase, the narrow phase and
Phlegm pipe forms the phase (perforation phase).The lesion of this disease is distributed in segment, distinct spaced with normal intestinal segment, is in skip zone
The feature of (skip area).The clinical manifestation of this disease is more various, with the position of enteral lesion, range, severity, the course of disease
Length and that whether there is or not complication is related.Model case is mostly in adolescence slow onset, and the course of disease is often more than the several months to several years.Activity
Phase and paracmasis are different in size, alternate appearance, are in gradual progress in recurrent exerbation.A small number of Acute onsets, can have high fever,
Toxemic symptoms and acute abdomen performance, there is severe complication more.Occasionally have parenteral with paranal peripheral abscess, the formation of phlegm pipe or arthralgia etc.
The person that shows as onset symptoms.
Crohn disease is as a kind of disease of chronic recurrent exerbation, due to its etiology unknown, causes there is no and develop effectively
Medicine, currently, for Crohn disease treatment drug mainly include glucocorticoid, Salicylic Acid Formulations, immunosupress
The biological agents such as agent, antibiotic, although these existing drugs can change the symptom of disease to a certain extent, not
The state of an illness of energy complete incidence graph disease and the incidence for reducing complication, and these existing hormone medicine long term administrations meeting pair
Body damages, and has apparent adverse reaction.Chinese medicine can make the most of the advantage on treating this disease, be held on the whole,
Enhance patient's resistance, alleviates the generation of complication, and then treat disease.
Invention content
The object of the present invention is to provide a kind of Chinese medicine preparation, which has treatment for being used to alleviate Crohn disease
With obvious effects, high efficiency is cheap, has no toxic side effect, feature convenient to take.
It is a further object of the present invention to provide the preparation methods of the Chinese medicine preparation for being used to alleviate Crohn disease.
Inventor observes the pain that Crohn disease is brought to patient, according to the disease in clinical treatment practice for many years
The rule of development of disease and the combination principle of Chinese medicine, and by a large amount of clinical verification, Exploration and conclusion goes out a kind of for delaying repeatedly
Solve Crohn disease Chinese medicine preparation new formula, the present invention select dark plum, Schisandra chinensis, asarum, rhizoma zingiberis, the coptis, Cortex Phellodendri, bletilla,
Radix Notoginseng powder, monkshood, Radix Angelicae Sinensis, Chinese cassia tree, red ginseng, Chinese prickly ash, radix bupleuri, cassia twig, Radix Paeoniae Alba, evodia rutaecarpa, nutmeg, psoralea corylifolia, Semen Coicis Semen Coicis,
Poria cocos, jujube, honey-fried licorice root are combined, and make each efficacy of drugs generate synergistic effect these pharmaceutical compositions, with puckery
The symptom of Crohn disease can be effectively relieved in the effect of intestines antidiarrheal, expelling pus and promoting granulation, nourishing generate fluid, heat-clearing and damp-drying drug, reduce concurrent
Disease mitigates patient's pain, and then achievees the purpose that treatment.
The effect of drug in the present invention：
Wherein：
Dark plum：For rose department plant plum Prunus mume（Sieh.）The nearly mellow fruit of drying of Sieb .et Zucc.
It is real.Nature and flavor：It is sweet, sour, puckery, warm.Return stomach, large intestine channel.Effect：Relieving diarrhea with astringents, astringing to arrest bleeding, expelling pus and promoting granulation.This product is used for sore carbuncle
It does not close up long after bursting, external application plays the role of hygroscopic expelling pus and promoting granulation.《Bencao Jingshu》：Mei Shi, the i.e. dark plum of the present are most sour.《Through》
It says：Heat impairing qi, evil visitor in the heart, then gas superinverse and dysphoria, the heart are uneasy for it.Dark plum is sour, can hold back superficial heat, and energy air-breathing returns member,
Therefore main lower gas, except hot dysphoria and feel at ease.Diarrhea person, large intestine collapse；Good saliva dry person, flaring up of deficient fire, body fluid deficiency；Acid
Energy hold back the fire of deficiency type, changes body fluid, Gu intestines are de-, so main.Its main limbs pain, hemiplegia meciless person are covered because moisture is dipped in channels and collaterals, then muscle
Arteries and veins relaxation is vertical or pain is meciless；Liver governing tendons, sour in taste acting on the liver and nourishing the muscle and tendon, liver, which obtains, to be supported, then solid skeleton and pliable tendons, organ's tonneau and preceding card except.
Schisandra chinensis：For magnoliaceae schisandra Schisandra chinensis（Turcz.）Or Central China five Baill.
The dry mature fruit of taste Schisandra sphenanthera Rehd. et Wils..Nature and flavor：It is warm, sour, sweet.Return lung,
The heart, kidney channel.Function：Restrain astringent method, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves.For long-last cough and virtual asthma, emission, enuresis frequent micturition, chronic diarrhea is not
Only, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitation and insomnia.
Asarum：For aristolochiaceae plant Herba Asari Asarum heterotropoides Fr. Schmidt
var.mandshuricum（Maxim.）Kitag., Seoul asarum Asarum sieboldii Miq. var. seoulense
The drying herb of Nakai or asarum sieboldii Asarum sieboldii Miq..Nature and flavor：It is pungent；Temperature；Mild toxicity.Distributed in lung channel, kidney channel, the heart
Through, Liver Channel, gallbladder channel, the spleen channel.Effect：Mass dissipating and swelling eliminating；Relieving exterior syndrome and dispelling cold；Wind-expelling pain-stopping；Warming lung and resolving fluid；Lower gas eliminating the phlegm, it is sensible.It is anti-
Bacterium, antivirus action kakuol preserved material, volatile oil etc. have gram positive bacteria, hay bacillus and typhoid bacillus certain external suppression
It makes and uses, decoction also has inhibiting effect to tubercle bacillus and typhoid bacillus.Herba Asari volatile oil is to a variety of fungies such as Aspergillus flavus, black
Aspergillus, Candida albicans etc. have inhibiting effect, and the active ingredient of antibacterial is safrole.α-asarone, which has, inhibits respiratory tract to close
The effect of cellular virus proliferation.
Rhizoma zingiberis：For the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor：It is pungent, hot.Returns spleen,
Stomach, the heart, lung channel.Effect：Warming spleen and stomach for dispelling cold, recover Yang and smooth venation, eliminating dampness dissolving phlegm, warming lung and resolving fluid.For coldness and pain in the epigastrium, vomiting and diarrhea, limb
Cold weak pulse, sputum cough.Rhizoma zingiberis external curing wound pyogenic infection.This product it is hot it is dry it is strong, main enter taste warp, be longer than it is warm in
Burnt spleen sun and cold dispelling, therefore all middle burnt cold cards, no matter the asthenia cold syndrome for the excessive cold syndrome or YANG QI deficiency invaded in exogeneous cold, be key medicine.
The coptis：For ranunculaceae plant coptis Coptis chinensis Franch., triangle leaf coptis Coptis
Deltoidea C. Y. Cheng et Hsiao or cloud connect the dry rhizome of Coptis teeta Wall..Nature and flavor：It is bitter, cold.
The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Major function：Heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, acid regurgitation is vomitted, is rushed down
Dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst, carbuncle swells furunculosis；Eczema is controlled outside,
Wet sore, duct are suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting.It is mutual for fever and chills
Knot, damp and hot middle resistance, feeling of fullness vomiting.The easypro liver anti-vomiting of cornel coptis.For liver-stomach disharmony, acid regurgitation is vomitted.This product heat-clearing and damp-drying drug, rushes down
Fire removing toxic substances, antibacterial action：Staphylococcus aureus, hemolytic streptococcus, pneumococcus, diplococcus meningitidis, shigella dysenteriae, charcoal
Subcutaneous ulcer bacillus etc..Detoxication：Bacteriotoxin is fought, staphylococcus aureus coagulase, hemolysin potency are reduced, reduces large intestine bar
The virulence of bacterium.It is jamaicin to inhibit kinds of experiments inflammation, active ingredient, and Anti-inflammatory Mechanism is discharged with stimulation corticotropin to be had
It closes.
Cortex Phellodendri：For rutaceae wampee Phellodendron chinense Schneid. or cork tree
The dry bark of Phellodendron amurense Rupr..Nature and flavor：It is bitter, cold.Return kidney, bladder, large intestine channel.Effect：Heat-clearing
Eliminating dampness, purging intense heat and detonicating remove hectic fever due to yin clearind deficient heat.For damp-heat dysentery, jaundice, under band, heat gonorrhea, tinea pedis, impotence wards off, and hectic fever due to yin labor heat is stolen
Sweat, seminal emission, sore swollen toxin, eczema itch.Modern pharmacology research：Cortex Phellodendri water decoction or alcohol preserved material are in vitro to golden yellow grape
Coccus, staphylococcus albus, hemolytic streptococcus, Diplococcus pneumopniae, bacillus anthracis, comma bacillus, corynebacterium diphtheriae, withered grass bar
Bacterium, Escherichia coli, Pseudomonas aeruginosa, typhoid bacillus, paratyphosum Bacterium, diplococcus meningitidis etc. have different degrees of inhibition to make
With experiments also show, Cortex Phellodendri has stronger inhibiting effect to shigella flexneri, Shigella shigae in addition, Cortex Phellodendri is decocted
Agent, flooding agent have different degrees of inhibiting effect in vitro to a variety of pathogenic dermatophytes, Trichomonas vaginalis etc..This product can
Heat-clearing and damp-drying drug, but can purging intense heat and detonicating, take orally, external application it is effective, and Cortex Phellodendri has the function of broad-spectrum antiseptic.
Bletilla：For orchid family herbaceos perennial bletilla striata Bletilla striata（Thunb.）Reichb. f.'s is dry
Dry stem tuber.Nature and flavor：It is pungent, it is bitter, sweet, puckery, it is slightly cold.Return lung, liver, stomach.Effect：Astringing to arrest bleeding, detumescence and promoting granulation.It is spat for hemoptysis
Blood, traumatic hemorrhage, sore swollen toxin, chapped skin；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.《Book on Chinese herbal medicine is looked for the truth》Described in：Bletilla, side
Book had not only carried function and has entered lung hemostasis, but also carried and can control to fall and flutter folding bone, and soup fire burn, malignant sore carbuncle swells lose the dead flesh of subcutaneous ulcer, obtain it is non-like receiving,
It is seemingly puckery, like only more thanDo not know book speech function hemostasis person, is because of the puckery meaning of property；Book speech can control ulcer and damage the wounded, be because
The meaning that acrid flavour can dissipate.Have during this medicine is puckery it is scattered, bowl spares have it is broken, therefore book carry again go it is rotten, by the stasis of blood, raw new.
Radix Notoginseng powder：For panax araliaceae plant Panax notoginseng（Burk.）F. the dry root of H. Chen.It takes
Radix Notoginseng, cleaning, drying, fine ground powder.Nature and flavor：Sweet, slight bitter, temperature.Return liver, stomach.Effect：Dissipate stasis of blood hemostasis, detumescence ding-tong.For coughing up
Blood is spitted blood, and bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatic hemorrhage, and chest and abdomen twinge, tumbling and swelling.《Book on Chinese herbal medicine is looked for the truth》Described in：Radix Notoginseng, common people
Only know that function is stopped blooding bitterly, hardly realizes pain because blood stasis then aches work, blood stops because applying scattered then blood.The bitter temperature of Radix Notoginseng smell, can be in blood system
Its blood stasis.
Monkshood：For the processed goods of the sub- root of ranunculaceae plant rhizome of Chinese monkshood Aconitum carmichaeli Debx..Nature and flavor：
It is pungent, sweet, big heat；It is toxic.It belongs to the heart, kidney, spleen channel.Effect：Recuperating depleted yang, mends fire supporing yang, eliminating cold to stop pain.This product is hot dry strong, walks
Without keeping, can pass through 12 warps, can chase after yang depletion lost again and subsidize the Yuanyang of deficiency, with tonic with using, can control one
Descend the card that yang-energy is on the decline, yin-cold excess with it, can on help heart-yang to promote blood circulation, medium temperature spleen sun is with strong fortune, and lower warm kidney sun is with beneficial fire, spleen
Coldness and pain in the epigastrium, diarrhea caused by kidney-yang deficiency, cold-damp accumulating in the interior often match rhizoma zingiberis.
Radix Angelicae Sinensis：For the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor：
It is sweet, pungent, bitter, temperature.Return liver, the heart, the spleen channel.Effect：It enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.Radix Angelicae Sinensis Central nervous system
There are inhibiting effect, volatile oil to have the effects that calmness, hypnosis, analgesia, anesthesia.For blood deficiency chlorosis, dizziness palpitaition, asthenia cold abdominalgia,
Arthralgia pain due to rheumatism, injury from falling down, ulcer sores.According to《Book on Chinese herbal medicine is just》It carries：" its is sweet in flavor and weighs, therefore can specially enrich blood, and gas is light and pungent, therefore
Again can promoting circulation of blood, nutrition blood can be supported, tonifying Qi production of sperm, five viscera settling, strengthen body, beneficial mind, all tangible deficient diseases are omni-benefiting." existing
It is confirmed for medical research, Radix Angelicae Sinensis has antibacterial, antiinflammation.
Chinese cassia tree：For the bark of canella Chinese cassia tree Cinnamomum cassia Presl.Nature and flavor：Big heat, it is pungent, sweet.Return
Kidney, spleen, the heart, Liver Channel.Effect：Mends fire supporing yang, let the fire back to its origin, eliminating cold to stop pain, invigorate blood circulation, promoting blood circulation.The sweet heat of this product, enters spleen kidney
Through being good at yang-tonifying gas and warming up spleen and kidney, eliminating cold to stop pain.
Red ginseng：For drying of the cultivation product after steaming of Araliaceae ginseng Panax ginseng C. A. Mey.
Root.Nature and flavor：Sweet, slight bitter, temperature.Returns spleen, lung, the heart channel of Hang-Shaoyin.Effect：It reinforces vital energy, veins takes off admittedly, nourishing qi to stop.
Chinese prickly ash：For rutaceae green pepper（Fragrant green pepper, pericarpium zanthoxyli schinifolii, Chinese pepper, dog green pepper）Zanthoxylum schinifolium
Sieb. et Zucc. or Chinese prickly ash（Another name for Sichuan Province green pepper, pericarpium zanthoxyli, hot red pepper, pericarpium zanthoxyli bungeani, clovershrub）Zantho xylum bungeanum
Maxim. dry mature skin（Chinese prickly ash）And seed（Green pepper mesh）It is used as medicine.Nature and flavor：It is acrid in flavour and warm in nature.Returns spleen, stomach, kidney channel.Effect：Middle benefit gas
Analgesic, desinsection are antipruritic.For coldness and pain in the epigastrium, vomiting and diarrhea, abdominal pain due to enterositosis, ascariasis；Control eczema itch outside.
Radix bupleuri：For Umbelliferae herbaceos perennial radix bupleuri Bupleurum chinense DC.（Bupleurum Chinese）Or narrow leaf bavin
Hu Bupleurum scorzonerifolium Willd.（RADIX BUPLEURI SCORZONERAEFOLII）Root or herb.Nature and flavor：It is bitter, pungent, be slightly cold.Return liver, courage
Through.Effect：Reducing fever by reconciliation, soothing liver-qi stagnation, yang invigorating.Radix bupleuri has the function of good soothing liver-qi stagnation, to treat hepatic depression
Stagnant key medicine, it is no matter interior to pain over the hypochondriac region by liver depression, outside by hindering servant person, it can all apply.
Cassia twig：For the dry twig of canella Chinese cassia tree Cinnamomum cassia Presl.Nature and flavor：Acrid, sweet, warm.
The thoughts of returning home, lung, bladder warp.Effect：Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.Cassia twig is warm-natured, the kind gas that activates yang, energy
Change cold sensation of the genitalia, resistance yang-energy held back to cold sensation of the genitalia, body fluid cannot defeated cloth, thus retention of water-damp forms the illness of phlegm and retained fluid.This product energy warming meridian,
Eliminating cold to stop pain, for all pain cards such as congealing cold with blood stasis.
Radix Paeoniae Alba：For the dry root of dicotyledon ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall..Property
Taste：Cool, picric acid is slightly cold.Effect：It enriches blood soft liver, smooth liver and relieve pain, holds back and cloudy receive sweat.Research shows that：The Paeoniflorin contained in Radix Paeoniae Alba has
Antibacterial, improves myocardial nutritional flow, expansion blood vessel, confrontation acute myocardial ischemia, suppression at antipyretic, anti-inflammatory, increase coronary flow
Platelet aggregation processed, calmness, analgesia, spasmolysis, antiulcer, the effect for adjusting blood glucose.Radix Paeoniae Alba decoction can inhibit shigella dysenteriae, pneumonia
Streptococcus, Escherichia coli, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa etc..This product energy nourishing the liver blood, hold back liver-yin, suppression liver-yang,
Dispersing liver-energy, and contraction urgency can be delayed, relieved the pain bitterly, to treat the good medicine of the various pain of Liver Channel.
Evodia rutaecarpa：For rutaceae evodia rutaecarpa Evodia rutaecarpa（Juss.）Benth., Shi Hu Evodia
rutaecarpa（Juss.）Benth. var. officinalis （Dode）Huang or thin hair evodia rutaecarpa Evodia
rutaecarpa （Juss.）Benth. var. bodinieri （Dode）The drying almost ripe fruit of Huang.Nature and flavor：Pungent,
Hardship, heat；It is slightly poisonous.Return liver, spleen, stomach, kidney channel.Effect：Eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For jueyin headache, tremble with fear
Hernia abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal distention vomit acid regurgitation, and Diarrhoea controls aphtha outside；Hypertension.This product temperature energy
Reinforcing spleen and kidney, supporing yang antidiarrheal, to control the common medicine of the insufficiency of both the spleen and the kindey, Diarrhoea.
Nutmeg：For the drying kind of Myristicaceae Myristica plant nutmeg Myristica fragrans Houtt.
Benevolence.Nature and flavor are acrid in flavour and warm in nature.Returns spleen, stomach, large intestine channel.Effect：Middle benefit gas promoting the circulation of qi, relieving diarrhea with astringents.For deficiency-cold in spleen and stomach, endless diarrhea, gastral cavity abdomen
Distending pain, deficiency of food vomiting.《A supplement to augmented materia medica》：Nutmeg, middle benefit gas tonifying spleen are ball.Solar corona claims its lower gas, with its spleen must be mended
Kind transporting, gas is under, if non-dried orange peel, rhizoma cyperi Jue are let out.
Psoralea corylifolia：For the fruit of legumes psoraleae Psoralea corylifolia L..Nature and flavor：It is pungent, bitter, temperature.Return
Kidney, the spleen channel.Effect：Tonifying kidney and strengthening yang, astringent sperm contracting urine is warming spleen and stopping diarrha, and gas of receiving is relievingd asthma.This product energy kidney-replenishing, warm spleen sun, stopping leak rush down,
To control the key medicine of the insufficiency of both the spleen and the kindey.This product is worked hard temperate-dryness, can pyretic tonification of kidney yang, replenishing kidney, strengthening waist, establishing-Yang, controlling nocturnal emission with astringent drugs, contracting urine, to control kidney yang not
The key medicine of foot, instability of kidney-QI.
Semen Coicis Semen Coicis：For grass Job's tears Coix lacryma-jobi L. var. ma-yuen（Roman.）
The dry mature kernal of Stapf.Nature and flavor：It is sweet, light, cool.Returns spleen, stomach, lung channel.Effect：Invigorating the spleen excreting dampness, eliminating impediment and relieving pain, heat-clearing row
Purulence.For oedema, tinea pedis, difficult urination, arthritis with fixed pain caused by dampness contraction, splenasthenic diarrhea, lung carbuncle, acute appendicitis；Flat wart.For retention of damp-heat in the interior it
Disease can be equal with talcum, the stem pith of the rice-paper plant and use to scanty drak urine；To damp-warm syndrome disease and evil in qi leel, the inclined victor of damp evil.
Poria cocos：For On Polyporaceae Poria cocos Poria cocos（Schw.）The dry sclerotia of Wolf.Nature and flavor：Sweet,
It is light, flat.The thoughts of returning home, lung, spleen, kidney channel.Effect：Clearing damp and promoting diuresis, invigorating the spleen calming heart.Sweet provide additional supplies of this product is oozed, and has not only been mended but also sharp, and effect is gentle,
It is mild-natured and partially without fever and chills, it is the key medicine of clearing damp and promoting diuresis.When treating the oedema of the wet expert of water, often match rhizoma alismatis, umbellate pore furgus.Poria cocos decoction
There is apparent sedation.《Modality》：It " cures mainly and throbs with fear that Ji Rou Shun muscle is cautious, and a dizzy agitation is controlled on side." this product felt at ease by heart-spleen boosting
God.Be chiefly used in the insufficiency of heart and spleen, insufficiency of vital energy and blood it is confused and worried.
Jujube：For Rhamnaceae jujube jujube Ziziphus jujuba Mill. var. inermis（Bunge）
Rehd. dry mature fruit.Nature and flavor：Sweet, warm.Returns spleen, stomach.Effect：Fruit（Jujube）：Tonifying middle-Jiao and Qi, nourishing blood and tranquilization.With
In spleen eating less, weak loose stool, hysteria of womam.Bark：Anti-inflammatory, hemostasis, antidiarrheal.For tracheitis, enteritis, dysentery, uterine bleeding；Outside
With controlling traumatic hemorrhage.Root：Promoting the circulation of qi, promoting blood circulation, menstruation regulating.It is red to collapse for irregular menstruation, leukorrhea.《This warp》：Main trusted subordinate's perverse trend, An Zhong
Spleen is supported, 12 warps are helped.Flat stomach gas leads to nine orifices, mends few gas, few body fluid, insufficient, frightened, heaviness of limbs and hundred medicines in body.《Book on Chinese herbal medicine is again
Newly》：Tonifying middle-Jiao and Qi, nourshing kidney warm stomach, controls the deficiency of Yin.
Honey-fried licorice root：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix
The drying root and rhizome of Glycyrrhiza Inflata Bat. or glycyrrhiza glabra Glycyrrhiza Glabra L..Honey-fried licorice root
Processed goods is baked for the honey of Radix Glycyrrhizae.Nature and flavor：Sweet and neutral.The thoughts of returning home, lung, spleen, stomach.Effect：Tonifying spleen and stomach, Yiqi and vein recovery.《Solar corona
Sub- book on Chinese herbal medicine》：Peace soul determines soul.General debility is mended, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, strengthening the essence are fostered the spirit of nobility, are strengthened
Muscles and bones, solution are cold and hot.
The present invention square solution be：Dark plum relieving diarrhea with astringents, expelling pus and promoting granulation in side, Schisandra chinensis restrain astringent method, nourishing generate fluid, asarum
Mass dissipating and swelling eliminating, rhizoma zingiberis warming spleen and stomach for dispelling cold, warming lung and resolving fluid, the coptis, Cortex Phellodendri heat-clearing and damp-drying drug, purging intense heat and detonicating, the above Six-element is monarch drug in a prescription altogether, first
The first coptis, Cortex Phellodendri heat-clearing and damp-drying drug, there is antibacterial anti-inflammatory, can clear up enteron aisle lesion, and dark plum, Schisandra chinensis etc. have sore life
The effect of flesh, nourishing generate fluid promotes the cleaning and healing of enteron aisle ulcer surface, prevents the diffusion once again of abscess and granulation, to
Achieve the purpose that control disease.Bletilla astringing to arrest bleeding, detumescence and promoting granulation, Radix Notoginseng powder dissipate stasis of blood hemostasis, detumescence ding-tong, monkshood Hui Yang are rescued
Inverse, eliminating cold to stop pain, Chinese angelica blood supplementing promoting blood circulation, Chinese cassia tree eliminating cold to stop pain, invigorate blood circulation, red ginseng veins takes off admittedly, nourishing qi to stop, Chinese prickly ash middle benefit gas
Analgesic, desinsection are antipruritic, radix bupleuri reducing fever by reconciliation, soothing liver-qi stagnation, and above several tastes are ministerial drug altogether, with dissipate stasis of blood hemostasis, detumescence ding-tong
Effect mitigates the pain that Crohn disease is brought to patient, and the soothing liver-qi stagnations such as red ginseng, radix bupleuri, veins takes off admittedly enhance the body of patient
Matter accelerates the recovery of patient.Cassia twig warming meridian, helps yang transforming qi, Radix Paeoniae Alba are enriched blood soft liver, smooth liver and relieve pain, evodia rutaecarpa eliminating cold to stop pain,
Supporing yang antidiarrheal, the promoting the circulation of qi of nutmeg middle benefit gas, relieving diarrhea with astringents, psoralea corylifolia warms up spleen sun, stopping leak rushes down, and Semen Coicis Semen Coicis invigorating the spleen excreting dampness, eliminating impediment are stopped
Bitterly, Poria cocos clearing damp and promoting diuresis, jujube tonifying middle-Jiao and Qi, nourishing blood and tranquilization, above several tastes are altogether adjutant, improve the body of patient, reinforce medicine
Object curative effect promotes patient to restore.Honey-fried licorice root priming channel tropism, coordinating the drug actions of a prescription, to make medicine.This side's all medicines share, the monarch and his subjects pull together, and assistant makes
It is auxiliary altogether, have effects that relieving diarrhea with astringents, expelling pus and promoting granulation, nourishing generate fluid, heat-clearing and damp-drying drug, can be effectively relieved and treat Crow grace
Disease.
Medicine material dosage of the present invention is largely groped summary through inventor's progress and is obtained, each raw material dosage is following
Parts by weight range all has having a better effect：15-25 parts of dark plum, 7-17 parts of Schisandra chinensis, 1-5 parts of asarum, 10-20 parts of rhizoma zingiberis, Huang
Even 3-9 parts, it is 7-17 parts of Cortex Phellodendri, 4-14 parts of bletilla, 1-5 parts of Radix Notoginseng powder, 7-17 parts of monkshood, 10-20 parts of Radix Angelicae Sinensis, 3-9 parts of Chinese cassia tree, red
5-15 parts of ginseng, 3-9 parts of Chinese prickly ash, 7-17 parts of radix bupleuri, 7-17 parts of cassia twig, 10-20 parts of Radix Paeoniae Alba, 3-9 parts of evodia rutaecarpa, nutmeg 4-14
Part, 10-20 parts of psoralea corylifolia, 15-25 parts of Semen Coicis Semen Coicis, 10-20 parts of Poria cocos, 7-17 parts of jujube, 3-9 parts of honey-fried licorice root.
Wherein it is preferably：20 parts of dark plum, 12 parts of Schisandra chinensis, 3 parts of asarum, 15 parts of rhizoma zingiberis, 6 parts of the coptis, 12 parts of Cortex Phellodendri, bletilla
9 parts, it is 3 parts of Radix Notoginseng powder, 12 parts of monkshood, 15 parts of Radix Angelicae Sinensis, 6 parts of Chinese cassia tree, 10 parts of red ginseng, 6 parts of Chinese prickly ash, 12 parts of radix bupleuri, 12 parts of cassia twig, white
15 parts of Chinese herbaceous peony, 6 parts of evodia rutaecarpa, 9 parts of nutmeg, 15 parts of psoralea corylifolia, 20 parts of Semen Coicis Semen Coicis, 15 parts of Poria cocos, 12 parts of jujube, honey-fried licorice root 6
Part.
The conventional fabrication process of Chinese medicine preparation may be used in drug of the present invention, can be made into any type pharmacy described
Dosage form, such as pill, powder, tablet, capsule, granule, syrup, oral solution.Such as these bulk pharmaceutical chemicals can be ground into
Powder-mixed is uniformly made powder and takes after mixing it with water；Decocting can be used, through filtering to get filtrate, preservative is added, oral solution is made；It is necessary
When can also directly take decoction.
Currently preferred preparation method is decoction, and preparation method is as follows：
Step 1：By weight proportion of the present invention, dark plum, Schisandra chinensis, Chinese prickly ash, evodia rutaecarpa, nutmeg, psoralea corylifolia, life are weighed
Coix seed, jujube are bundled into pack with gauze, are put in cold water and impregnate 15-25 minutes, spare；
Step 2：It by weight proportion of the present invention, weighs monkshood and is put into marmite, remaining 1-2 lis of cold water in step 1 is added
Rice decocts 20 minutes, then weighs rhizoma zingiberis, the coptis, Cortex Phellodendri, bletilla, Radix Angelicae Sinensis, Chinese cassia tree, red ginseng, Radix Paeoniae Alba and be put into marmite with high heat
In, remaining cold water after step 1 is impregnated is added, smeared 3-5 centimetres of medicinal material, and first boiled with high heat, then divided with 30-40 is cooked by slow fire
Clock, filtering, obtains filtrate, and 2-3 centimetres of water is added in the remaining dregs of a decoction, asarum, radix bupleuri, Poria cocos and step 1 is then added
The pack of kind continues to decoct 20 minutes, is eventually adding cassia twig, honey-fried licorice root decoction 15 minutes, and filtering obtains filtrate, and merging is filtered twice
Liquid, waste are spare；
Step 3：By weight proportion of the present invention, weigh Radix Notoginseng powder and taken after mixing it with water with the hot soup in step 2, both institute of the present invention
It states, alleviates the traditional Chinese herbal decoction of Crohn disease.
Drug of the present invention has relieving diarrhea with astringents, expelling pus and promoting granulation, nourishing generate fluid, heat-clearing and damp-drying drug and other effects, and with obvious effects, has
It is efficient, it is cheap, it has no toxic side effect, it is convenient to take, it can effectively alleviate the pain that Crohn disease is brought to patient, subtract
The generation of few complication, improves patient body, and then achieve the purpose that treatment.
Specific implementation mode
Embodiment one, 15 parts of dark plum, 7 parts of Schisandra chinensis, 1 part of asarum, 10 parts of rhizoma zingiberis, 3 parts of the coptis, 7 parts of Cortex Phellodendri, 4 parts of bletilla,
1 part of Radix Notoginseng powder, 7 parts of monkshood, 10 parts of Radix Angelicae Sinensis, 3 parts of Chinese cassia tree, 5 parts of red ginseng, 3 parts of Chinese prickly ash, 7 parts of radix bupleuri, 7 parts of cassia twig, 10 parts of Radix Paeoniae Alba,
3 parts of evodia rutaecarpa, 4 parts of nutmeg, 10 parts of psoralea corylifolia, 15 parts of Semen Coicis Semen Coicis, 10 parts of Poria cocos, 7 parts of jujube, 3 parts of honey-fried licorice root.
Embodiment two, 20 parts of dark plum, 12 parts of Schisandra chinensis, 3 parts of asarum, 15 parts of rhizoma zingiberis, 6 parts of the coptis, 12 parts of Cortex Phellodendri, bletilla 9
It is part, 3 parts of Radix Notoginseng powder, 12 parts of monkshood, 15 parts of Radix Angelicae Sinensis, 6 parts of Chinese cassia tree, 10 parts of red ginseng, 6 parts of Chinese prickly ash, 12 parts of radix bupleuri, 12 parts of cassia twig, white
15 parts of Chinese herbaceous peony, 6 parts of evodia rutaecarpa, 9 parts of nutmeg, 15 parts of psoralea corylifolia, 20 parts of Semen Coicis Semen Coicis, 15 parts of Poria cocos, 12 parts of jujube, honey-fried licorice root 6
Part.
Embodiment three, 25 parts of dark plum, 17 parts of Schisandra chinensis, 5 parts of asarum, 20 parts of rhizoma zingiberis, 9 parts of the coptis, 17 parts of Cortex Phellodendri, bletilla 14
It is part, 5 parts of Radix Notoginseng powder, 17 parts of monkshood, 20 parts of Radix Angelicae Sinensis, 9 parts of Chinese cassia tree, 15 parts of red ginseng, 9 parts of Chinese prickly ash, 17 parts of radix bupleuri, 17 parts of cassia twig, white
20 parts of Chinese herbaceous peony, 9 parts of evodia rutaecarpa, 14 parts of nutmeg, 20 parts of psoralea corylifolia, 25 parts of Semen Coicis Semen Coicis, 20 parts of Poria cocos, 17 parts of jujube, honey-fried licorice root 9
Part.
Here is clinical statistics data of the patient using drug of the present invention：
One, general information
Accept patient 60, wherein male 31 for medical treatment, women 29, male to female ratio is about 1.07:1, max age 68 years old, most
30 years old small age, course of disease time etc., the items basic document such as Gender, age, course of disease are essentially identical.
Two, therapy
According to the embodiment of the present invention two, bulk pharmaceutical chemicals are weighed（One daily dose）, decocting, filter and remove residue is taken in two divided doses, 10
It is as a treatment course.
Model case and curative effect：
Case one, Zheng, female, 55 years old, there is diarrhea, abdominal pain repeatedly in patient, and has the phenomenon that weight loss, patient's abdominal pain
When often go to hospital to take a point antiphlogistic, anodyne will soon recur although symptom can be alleviated, the recent abdomen of patient
Pain aggravates, and decision goes to hospital to check, electronic colonoscope and Mucosa Biopsy are diagnosed as Crohn disease, and patient is implemented using the present invention
Made preparation in example two, and the preparation method preferably selected, after taking two courses for the treatment of, patient's abdominal pain, diarrhea phenomenon disappear substantially
It loses, weight is increased back up, and constitution obviously takes a turn for the better, and patient holds on again takes a wheat harvesting period, patient's readme physical condition
Well, hospital is gone to check, intestinal mucosal lesion restores substantially, and livelihood restoration is normal, and follow-up is not recurred.
Case two, Guo, man, 69 years old, patient's abdominal distension, diarrhea, and with discontinuity navel week abdominal pain, defecation is unsmooth, has
Row feels not to the utmost, and patient is recent and has the fever of unknown cause, after oral antibiotic is brought down a fever, will not recur in a few days, patient goes
Hospital is checked, is finally diagnosed as Crohn disease, patient uses made preparation in the embodiment of the present invention two, and preferably selects
Preparation method, after taking two courses for the treatment of, abdominal pain, diarrhea phenomenon are significantly improved, and patient has not occurred since medication
Fever phenomenon is crossed, appetite obviously increases, and constitution is also strengthened, and patient adheres to having taken one month or so again, and hospital is gone to check,
Intestinal mucosa returns to normal, and the state of an illness is controlled, and life is unaffected, and follow-up is not recurred.
Claims (3)
1. a kind of Chinese medicine preparation for alleviating Crohn disease, which is characterized in that the Chinese medicine preparation is by the medicine of following parts by weight
Object forms：It is 15-25 parts of dark plum, 7-17 parts of Schisandra chinensis, 1-5 parts of asarum, 10-20 parts of rhizoma zingiberis, 3-9 parts of the coptis, 7-17 parts of Cortex Phellodendri, white
And 4-14 parts, 1-5 parts of Radix Notoginseng powder, 7-17 parts of monkshood, 10-20 parts of Radix Angelicae Sinensis, 3-9 parts of Chinese cassia tree, 5-15 parts of red ginseng, 3-9 parts of Chinese prickly ash, bavin
7-17 parts of Hu, 7-17 parts of cassia twig, 10-20 parts of Radix Paeoniae Alba, 3-9 parts of evodia rutaecarpa, 4-14 parts of nutmeg, 10-20 parts of psoralea corylifolia, raw Job's tears
15-25 parts of benevolence, 10-20 parts of Poria cocos, 7-17 parts of jujube, 3-9 parts of honey-fried licorice root.
2. the Chinese medicine preparation according to claim 1 for alleviating Crohn disease, which is characterized in that by following parts by weight
Drug forms：20 parts of dark plum, 12 parts of Schisandra chinensis, 3 parts of asarum, 15 parts of rhizoma zingiberis, 6 parts of the coptis, 12 parts of Cortex Phellodendri, 9 parts of bletilla, Radix Notoginseng powder
3 parts, 12 parts of monkshood, 15 parts of Radix Angelicae Sinensis, 6 parts of Chinese cassia tree, 10 parts of red ginseng, 6 parts of Chinese prickly ash, 12 parts of radix bupleuri, 12 parts of cassia twig, 15 parts of Radix Paeoniae Alba, Wu
6 parts of the fruit of medicinal cornel, 9 parts of nutmeg, 15 parts of psoralea corylifolia, 20 parts of Semen Coicis Semen Coicis, 15 parts of Poria cocos, 12 parts of jujube, 6 parts of honey-fried licorice root.
3. the Chinese medicine preparation according to claim 1 or 2 for alleviating Crohn disease, it is characterised in that：The Chinese medicine system
Agent is decoction.
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