CN117731737A - Throat-clearing and-wetting lozenge - Google Patents

Abstract

The invention discloses a throat-clearing throat-moistening lozenge which is prepared by extracting the following raw materials in parts by weight, namely, 10-20 parts of dark plum, 8-12 parts of fragrant solomonseal rhizome, 5-15 parts of phyllanthus emblica, 10-20 parts of momordica grosvenori, 10-18 parts of bunge cherry seed, 8-122 parts of exocarpium citri rubrum, 10-20 parts of platycodon grandiflorum, 8-12 parts of sea buckthorn, 5-15 parts of peach seed, 20-30 parts of honeysuckle, 15-25 parts of poria cocos and 12-20 parts of lophatherum gracile, and has the effects of nourishing yin, promoting the production of body fluid, soothing liver, regulating qi, resolving phlegm, activating blood and dissolving stasis, relieving swelling, expelling pus, strengthening spleen and promoting digestion, and is used for jointly treating yin deficiency and fire hyperactivity type chronic pharyngitis.

Description

A kind of throat clearing lozenge

Technical field

The invention relates to a throat clearing and moistening lozenge and a preparation method thereof, and belongs to the technical field of health care products.

Background technique

With the acceleration of the pace of modern life and the intensification of environmental pollution, respiratory diseases such as throat discomfort and cough have become common problems affecting people's health. Traditionally, lozenges and lozenges are mainly made from natural ingredients such as sugar, honey, and plant extracts through processing. This type of product usually has a certain effect in relieving throat discomfort, but its ingredients are single, the effect is not long-lasting, and there are also some inconveniences in terms of taste and portability. With the advancement of science and technology and people's increasing demand for health, the lozenge industry has begun to introduce some functional additives, such as menthol, vitamin C, etc., to enhance the efficacy and taste of the product, but the efficacy is not guaranteed. The market urgently needs an oral lozenge with obvious effects for both medicinal and food purposes.

Contents of the invention

The object of the present invention is to provide a throat-clearing lozenge and a preparation method thereof. Through the proportioning of ebony plum, Polygonatum odoratum, Phyllanthus emblica, Luo Han Guo, Yu Liren, Tangerine, Platycodon, sea buckthorn, peach kernel, honeysuckle, Poria cocos and light bamboo leaves, It is mainly used to treat chronic pharyngitis due to yin deficiency and excessive fire, and to solve the above-mentioned problems.

A throat clearing and moistening lozenge is prepared by extracting and preparing the following raw materials by weight: 10-20 parts of ebony plum, 8-12 parts of Polygonatum odoratum, 5-15 parts of Phyllanthus emblica, 10-20 parts of Luo Han Guo, and Yu Liren 10-18 parts, orange 8-122 parts, Platycodon 10-20 parts, sea buckthorn 8-12 parts, peach kernel 5-15 parts, honeysuckle 20-30 parts, Poria 15-25 parts, light bamboo leaves 12-20 parts.

The throat-clearing and moistening lozenges are prepared by extracting and preparing the following raw materials by weight: 15 parts of ebony plum, 10 parts of Polygonatum odoratum, 10 parts of Phyllanthus emblica, 15 parts of Luo Han Guo, 14 parts of Yu Liren, 10 parts of Tangerine, Platycodon grandiflorum. 15 parts, 10 parts sea buckthorn, 10 parts peach kernels, 25 parts honeysuckle, 20 parts poria, and 16 parts light bamboo leaves.

The throat clearing and moistening lozenges are prepared by extracting and preparing the following raw materials by weight: 10 parts of ebony plum, 12 parts of Polygonatum odoratum, 5 parts of Phyllanthus emblica, 20 parts of Luo Han Guo, 10 parts of Yu Li Ren, 12 parts of Tangerine, Platycodon grandiflorum. 10 parts, 12 parts sea buckthorn, 5 parts peach kernels, 30 parts honeysuckle, 15 parts poria, and 20 parts light bamboo leaves.

The throat-clearing and moistening lozenges are prepared by extracting and preparing the following raw materials for both medicinal and food use in parts by weight: 20 parts of ebony plum, 8 parts of Polygonatum odoratum, 15 parts of Phyllanthus emblica, 10 parts of Luo Han Guo, 18 parts of Yu Li Ren, 8 parts of Orange Red, Platycodon grandiflorum. 20 portions, 8 portions of sea buckthorn, 15 portions of peach kernels, 20 portions of honeysuckle, 25 portions of poria, and 12 portions of pale bamboo leaves.

The preparation method of the throat clearing and moistening lozenges is as follows: take black plum, Polygonatum odoratum, Phyllanthus emblica, Luo Han Guo, Yu Liren, Tangerine, Platycodon, seabuckthorn, peach kernel, honeysuckle, Poria, and Phyllanthus leaves for later use. Among them, Phyllanthus emblica, Tangerine, peach kernel, Add water to honeysuckle, extract it with continuous reflux for 3-5 hours by steam distillation, filter, and save the volatile oil and liquid; combine the medicinal residue with other raw materials, add water and heat to reflux for 120-180 minutes, extract twice, and combine the extracts and concentrate under reduced pressure. After spray drying, the dry extract powder can be obtained, adding flavoring agents and lubricants, wet granulating, drying, spraying into whole granules, adding volatile oil and lubricants extracted from amla, tangerine, peach kernel, honeysuckle, and tableting. That’s it.

Chronic pharyngitis refers to the lesions caused by chronic infection of the pharynx. In traditional Chinese medicine, it is called "plum core qi". It mostly occurs in adults and is often accompanied by other throat symptoms. Therefore, it is recorded in traditional Chinese medicine books: "Plum core qi is a suffocation in the throat." "It's like being stuck in the middle, unable to cough up, unable to swallow, and has a nuclear state." This disease often occurs due to depression, smoking, and mood swings. The throat is dry, burning, swollen, itchy, and blocked, etc. , but less likely to have sore throat. Coughing is often used to clear secretions, and thick phlegm is often spit out in the morning, which can easily cause nausea. Chronic pharyngitis often occurs on the basis of deficiency of yin and yang, qi and blood in the organs, and generally has a long course. Clinical findings show that yin deficiency is more common and yang deficiency is relatively rare. There are also cases where phlegm coagulation or blood stasis is caused by yin deficiency or yang deficiency, and the symptoms are deficiency and excess.

Lung and kidney yin fluid is insufficient, and the throat is not nourished, so the throat is dry and painful or feels like a foreign body; Yin deficiency leads to strong fire, and if the fire is disturbed by deficiency, the throat will have a burning sensation and the cheekbones will be flushed; deficiency of fire will produce phlegm, and the dry phlegm will stick to the Throat: Itchy throat, dry cough, less and sticky phlegm; Yang Qi is strong in the morning, Yin Qi is strong in the afternoon, Yin deficiency means symptoms are light in the morning and severe in the evening, hot flashes in the afternoon; Insufficient Yin liquid means dry stool, and deficiency of fire disturbing the heart means deficiency and insomnia; Kidney deficiency means soreness and weakness in the waist and knees; a red tongue with less coating and a thready pulse are signs of yin deficiency and excess fire. Syndrome: dry throat pain and discomfort, burning sensation, foreign body sensation, or itchy throat and dry cough with less and sticky phlegm. Symptoms are mild in the morning and severe in the evening, which may be accompanied by afternoon hot flashes, cheekbone flushing, irritability and insomnia, dry stool, and waist pain. For symptoms such as soreness and weakness in the knees, check that the pharyngeal mucosa is dark red and dry, the tongue is red and less fluid, the coating is sparse or peeling, and the pulse is thready and rapid. First, due to yin deficiency and excessive fire, the deficiency fire disturbs the body, so the present invention adopts nourishing yin, promoting fluid production and soothing the throat; second, due to the deficiency of fire, refining body fluid to form phlegm, dry phlegm sticks to the throat, so it is necessary to soothe the liver, regulate qi and resolve phlegm; third, due to the chronic pharyngitis patient's condition worsening For a long time, it will cause blood stasis to enter the meridians. When the blood stasis blocks the meridians, the patient can see the proliferation of some follicles in the pharynx, or there will be some small bleeding spots in the pharynx. It is necessary to activate blood circulation, remove blood stasis and soothe the throat. The fourth reason is that due to the pharynx Inflammation occurs in the local mucosa, submucosal and lymphoid tissues. If the inflammation is not controlled in time, it may cause the tonsils to be irritated, resulting in abscesses. The swelling and pus need to be reduced. Fifthly, due to spleen deficiency, phlegm and phlegm-dampness are prone to occur. Stagnation can easily lead to insufficient Qi and blood, and stasis can turn into fire, which can easily cause chronic pharyngitis. It is necessary to strengthen the spleen and eliminate food; among them, black plum astringes the lungs, astringes the intestines, promotes fluid production, and calms roundworms, and Polygonatum odoratum nourishes yin and moisturizes dryness, promotes fluid production and quenches thirst. Ganzi clears away heat and cools blood, digests food and strengthens the stomach, produces fluid and relieves cough. Luo Han Guo clears away heat and moisturizes the lungs, relieves sore throat, smoothes the intestines and relieves constipation. It is a monarch medicine together; Yu Liren moistens the intestines and relieves constipation, lowers qi and diuresis, orange regulates qi and relieves dampness. Platycodon is used to relieve phlegm, soothe the throat, eliminate phlegm, and expel pus; sea buckthorn is a ministerial drug for strengthening the spleen and digestion, relieving cough and phlegm, promoting blood circulation and removing blood stasis; peach kernel is used as an adjuvant drug for promoting blood circulation and removing blood stasis, moisturizing the intestines and laxative, relieving cough and asthma; Honeysuckle clears away heat and purges fire, relieves irritability and thirst, is a diuretic and relieves stranguria. Poria cocos diuretics and dampness, invigorating the spleen and calms the heart. Bamboo leaves clear away heat and detoxify, remove carbuncle and pus, diuresis and relieve stranguria. To make medicine, the whole recipe contains black plum and polygonatum odorifera. , Emblica emblica, Momordica grosvenori, Yu Liren, Tangerine, Platycodon, sea buckthorn, peach kernel, honeysuckle, Poria, and bamboo leaves, can nourish yin and promote fluid production, soothe the liver, regulate qi and reduce phlegm, activate blood circulation and remove blood stasis, reduce swelling and pus, strengthen the spleen and digestion, and jointly treat yin. Chronic pharyngitis due to deficiency of fire and excess of fire.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments. It should be understood that these examples are only used to illustrate the invention and are not intended to limit the scope of the invention. In addition, it should be understood that after reading the content described in the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms also fall within the scope defined by the appended claims of this application.

Example 1: Take 1500g of ebony plum, 1000g of Polygonatum odoratum, 1000g of Phyllanthus emblica, 1500g of Momordica grosvenori, 1400g of Yuliren, 1000g of orange, 1500g of platycodon, 1000g of sea buckthorn, 1000g of peach kernel, 2500g of honeysuckle, 2000g of Poria, and 1600g of pale bamboo leaves. The preparation method is as follows: take ebony , Polygonatum odoratum, Phyllanthus emblica, Luo Han Guo, Yu Liren, Tangerine, Platycodon, seabuckthorn, peach kernel, honeysuckle, Poria, and Phyllostachys lucidum leaves for later use. Add water to Phyllanthus emblica, Tangerine, peach kernel, and honeysuckle, and continuously reflux and extract for 4 hours by steam distillation, and then filter. , preserve the volatile oil and liquid medicine; combine the medicine residue with other raw materials, add 10 times the weight of water and heat to reflux for 160 minutes, extract twice, concentrate the combined extracts under reduced pressure, and spray-dry to obtain dry extract powder. Flavoring agent and lubricant, wet granulation, drying, spraying into whole granules, adding volatile oil and lubricant extracted from amla, tangerine, peach kernel, honeysuckle, and tableting.

Example 2: Take 1000g of black plum, 1200g of Polygonatum odoratum, 500g of Phyllanthus emblica, 2000g of Momordica grosvenori, 1000g of plum blossom, 1200g of orange, 1000g of platycodon, 1200g of sea buckthorn, 500g of peach kernel, 3000g of honeysuckle, 1500g of poria, and 2000g of pale bamboo leaves. The preparation method is as follows: take the black plum , Polygonatum odoratum, Phyllanthus emblica, Luo Han Guo, Yu Liren, Tangerine, Platycodon, seabuckthorn, peach kernel, honeysuckle, Poria, and Phyllostachys lucidum leaves are set aside. Water is added to Phyllanthus emblica, Tangerine, peach kernel, and honeysuckle, and the water is continuously refluxed and extracted by steam distillation for 3 hours, and then filtered , preserve the volatile oil and liquid; combine the medicinal residue with other raw materials, add 10 times the weight of water and heat to reflux for 120 minutes, extract twice, combine the extracts and concentrate under reduced pressure, and spray-dry to obtain dry extract powder. Flavoring agent and lubricant, wet granulation, drying, spraying into whole granules, adding volatile oil and lubricant extracted from amla, tangerine, peach kernel, honeysuckle, and tableting.

Example 3: Take 2000g of ebony plum, 800g of Polygonatum odoratum, 1500g of Phyllanthus emblica, 1000g of Luo Han Guo, 1800g of plum blossoms, 800g of orange, 2000g of platycodon, 800g of sea buckthorn, 1500g of peach kernels, 2000g of honeysuckle, 2500g of Poria, and 1200g of pale bamboo leaves. The preparation method is as follows: take ebony , Polygonatum odoratum, Phyllanthus emblica, Luo Han Guo, Yu Liren, Tangerine, Platycodon, seabuckthorn, peach kernel, honeysuckle, Poria, and Phyllostachys lucidum leaves are set aside. Water is added to Phyllanthus emblica, Tangerine, peach kernel, and honeysuckle, and the water is continuously refluxed and extracted by steam distillation for 5 hours, and then filtered , preserve the volatile oil and medicinal solution; combine the medicinal residue with other raw materials, add 10 times the weight of water and heat and reflux for 180 minutes, extract twice, combine the extracts and concentrate under reduced pressure, and spray-dry to obtain dry extract powder. Add corrective Flavoring agent and lubricant, wet granulation, drying, spraying into whole granules, adding volatile oil and lubricant extracted from amla, tangerine, peach kernel, honeysuckle, and tableting.

Example 4: Clinical Study

Case selection: 100 patients with chronic pharyngitis of yin deficiency and fire exuberance type were collected in the outpatient clinic, including 52 males and 48 females, with an average age of 42.32 years old.

Diagnostic criteria:

Western medicine diagnostic criteria: (l) Medical history: There is often a history of recurrent acute pharyngitis, or long-term mouth breathing due to rhinitis, excessive smoking and alcohol, dry air in the environment, dust and irritating gas pollution, etc. (2) Symptoms: Pharyngeal discomfort, pain, itching, dryness, burning, smoke, foreign body sensation, etc.; irritating cough, coughing up secretions with force in the morning, or even nausea. The course of the disease is more than 2 months, and symptoms are often caused by colds, colds, fatigue, talkativeness and other reasons. (3) Examination: Chronic congestion in the pharynx worsens. Dark red, or dendritic congestion; hyperplasia of lymphatic follicles on the posterior pharyngeal wall, or swelling of the pharyngeal lateral cords; hyperplasia and hypertrophy of the pharyngeal mucosa, or dryness, atrophy, thinning, and secretions attached. Diagnosis can be made with each of the above symptoms and one or more examination findings.

Diagnostic criteria of traditional Chinese medicine: dry throat pain and discomfort, burning sensation, foreign body sensation, or itchy throat and dry cough with less and sticky phlegm. Symptoms are mild in the morning and severe in the evening, which may be accompanied by afternoon hot flashes, flushing of cheekbones, restlessness, insomnia, and dry stool. Symptoms such as soreness and weakness in the waist and knees, examination of the pharyngeal mucosa are dark red and dry, red tongue with less fluid, less or peeling fur, and thready pulse, and the patient is diagnosed as chronic pharyngitis of Yin deficiency and fire exuberance type.

Efficacy standards: refer to the "Traditional Chinese Medicine Industry Standard of the People's Republic of China "Standards for the Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes - Standards for the Diagnosis and Efficacy of Otorhinolaryngology Diseases and Syndromes" (1994).

(1) The evaluation criteria are as follows:

(1) Cure: Pharyngeal symptoms disappear, examination is normal, and points are reduced by ≥95%.

(2) Markedly effective: Pharyngeal symptoms are significantly relieved, local signs are significantly improved, and the points are reduced by ≥70% and <95%.

(3) Effective: Pharyngeal symptoms and signs are relieved, and the sign score is reduced by ≥30% and <70%.

(4) Invalid: There is no significant change in symptoms and signs, or the score is reduced by <30%.

(2) Evaluation methods

Scoring method: Based on the content of the above TCM syndrome quantification table, the doctor will fill in the outpatient scoring record after asking and examining the patient's condition, and score according to the patient's symptoms and signs.

Efficacy evaluation method: Score the patient's symptoms and signs five times before and after treatment, and judge the patient's symptoms and signs as cured, markedly effective, effective, or ineffective based on the change in the total score.

Results: Among 100 cases, after taking the lozenge prepared in Example 1 of the present invention, 32 cases were cured one month later, 26 cases were markedly effective, 35 cases were effective, and 7 cases were ineffective. The effective rate was 93%. No toxic or side effects occurred during the treatment period.

Typical case: Wang, male, 41 years old, a tour guide, suffered from dry throat pain and discomfort, burning sensation, foreign body sensation, or itchy throat, dry cough, less and sticky phlegm, symptoms that were mild in the morning and severe in the evening, which may be accompanied by hot flashes in the afternoon and cheekbones. For symptoms such as flushing, irritability and insomnia, dry stool, soreness and weakness of the waist and knees, check that the pharyngeal mucosa is dark red and dry, the tongue is red and less fluid, the coating is sparse or the flowers are peeling, and the pulse is thready. The patient is diagnosed as chronic pharyngitis of Yin deficiency and fire exuberance type. Use After treatment with the present invention, the symptoms disappear after two weeks, the patient recovers after one month, and there is no recurrence after a follow-up visit after one year.

Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art will understand that various changes, modifications, and substitutions can be made to these embodiments without departing from the principles and spirit of the invention. and modifications, the scope of the invention is defined by the appended claims and their equivalents.

Claims (5)

1. A throat clearing and moistening lozenge, characterized in that it is prepared by extracting and preparing the following raw materials by weight: 10-20 parts of ebony plum, 8-12 parts of Polygonatum odoratum, 5-15 parts of Phyllanthus emblica, and Luo Han Guo 10-20 parts, Yuli Ren 10-18 parts, Tangerine 8-122 parts, Platycodon 10-20 parts, Sea Buckthorn 8-12 parts, Peach Kernel 5-15 parts, Honeysuckle 20-30 parts, Poria 15-25 parts, Pale Bamboo Leaves 12- 20 servings. 2. Throat clearing and moistening lozenges as claimed in claim 1, characterized in that they are prepared by extracting and extracting the following raw materials by weight: 15 parts of black plum, 10 parts of Polygonatum odoratum, 10 parts of Phyllanthus emblica, and 15 parts of Luo Han Guo. , 14 parts of plum kernels, 10 parts of orange, 15 parts of Platycodon, 10 parts of sea buckthorn, 10 parts of peach kernels, 25 parts of honeysuckle, 20 parts of Poria, and 16 parts of pale bamboo leaves. 3. Throat clearing and moistening lozenges as claimed in claim 1, characterized in that they are prepared by extracting and extracting the following raw materials by weight: 10 parts of ebony plum, 12 parts of Polygonatum odorifera, 5 parts of Phyllanthus emblica, and 20 parts of Luo Han Guo. , 10 parts of Yu Liren, 12 parts of Tangerine, 10 parts of Platycodon, 12 parts of sea buckthorn, 5 parts of peach kernels, 30 parts of honeysuckle, 15 parts of Poria, and 20 parts of light bamboo leaves. 4. Throat clearing and moistening lozenges as claimed in claim 1, characterized in that they are prepared by extracting and extracting the following weight portions of medicinal and edible raw materials: 20 parts of ebony plum, 8 parts of Polygonatum odorifera, 15 parts of Phyllanthus emblica, and 10 parts of Luo Han Guo. , 18 parts of Yu Liren, 8 parts of Tangerine, 20 parts of Platycodon, 8 parts of Sea Buckthorn, 15 parts of Peach Kernel, 20 parts of Honeysuckle, 25 parts of Poria, and 12 parts of Pale Bamboo Leaves. 5. Throat clearing and moistening lozenges as claimed in claim 1, characterized in that the preparation method is as follows: take ebony plum, Polygonatum odoratum, Phyllanthus emblica, Luo Han Guo, Yu Liren, Tangerine, Platycodon, seabuckthorn, peach kernel, honeysuckle, Poria, Phyllanthus leaf. For later use, add water to Phyllanthus emblica, Tangerine, peach kernels, and honeysuckle, and use steam distillation to continuously reflux for 3-5 hours, filter, and store the volatile oil and medicinal solution; combine the medicinal residue with other raw materials, add water, heat and reflux for 120-180 minutes, and extract Twice, combine the extracts and concentrate under reduced pressure. After spray drying, dry extract powder can be obtained. Add flavoring agents and lubricants, wet granulate, dry, and spray into whole granules. Add Phyllanthus emblica, orange red, peach kernel, The volatile oil and lubricant extracted from honeysuckle can be obtained by pressing into tablets.