CN113197984A

CN113197984A - Traditional Chinese medicine composition for treating chronic wet cough of children and application thereof

Info

Publication number: CN113197984A
Application number: CN202110233118.9A
Authority: CN
Inventors: 姜永红; 肖臻; 丁国栋; 李文; 陈一柳; 李倩
Original assignee: Longhua Hospital Affiliated to Shanghai University of TCM
Current assignee: Longhua Hospital Affiliated to Shanghai University of TCM
Priority date: 2021-03-03
Filing date: 2021-03-03
Publication date: 2021-08-03

Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic wet cough of children, which is prepared from the following raw material medicines in parts by weight: 6-15 parts of roasted aster, 6-15 parts of roasted radix stemonae, 6-15 parts of bighead atractylodes rhizome, 3-9 parts of platycodon grandiflorum, 3-9 parts of periostracum cicadae, 6-15 parts of cynanchum glaucescens, 3-6 parts of liquorice, 3-9 parts of pinellia ternate, 3-9 parts of tangerine peel and 3-9 parts of arisaema cum bile. The traditional Chinese medicine composition can effectively improve the chronic wet cough symptom of children, shorten the course of disease and effectively solve the accompanying symptoms related to chronic cough patients. In addition, the invention also relates to application of the traditional Chinese medicine composition.

Description

Traditional Chinese medicine composition for treating chronic wet cough of children and application thereof

Technical Field

The invention relates to a traditional Chinese medicine composition for treating chronic wet cough of children, and in addition, the invention also relates to application of the traditional Chinese medicine composition.

Background

Chronic Cough (CC), also known as "chronic cough", is a common and frequently occurring disease in children, with cough duration > 4 weeks, with the main or only clinical symptoms ofCough, and no obvious abnormality of chest film. After infection with virus and mycoplasma, cough variant asthma, upper airway syndrome is a common cause of chronic cough. Foreign epidemiological survey shows that the incidence rate of chronic cough of the school-age children and preschool children is 9 percent respectively^[1]And 21.3%^[2]. For chronic cough, domestic studies show the incidence of most investigated diseases>10％(7.2％，33％)^[3]。

Chronic cough has a complicated etiology and a long course of disease, and many parents of children who suffer from the chronic cough are often diverted to various hospitals to seek treatment, so that the curative effect is not ideal. The hospital for treatment is continuously changed, and the continuous intermittent treatment causes the repeated and irregular use of antibiotics and hormones to occur, so that the physique of the infant patient is reduced, and the condition of the infant patient is more repeatedly and difficultly treated. Studies have shown that the repetition of the disease condition in children patients can lead to a reduction in the quality of life of children with chronic cough, and often lead to family contradiction or parental anxiety.

2006 American society of thoracic physicians in Children chronic cough management^[4]The concept of 'dry cough' and 'wet cough' is introduced for the first time in 'Chinese guidelines for diagnosing and treating chronic cough of children' in 2014. The etiology and constitution of dry cough and wet cough are different, so that classification and judgment of the dry cough and the wet cough have directional value for etiology and diagnosis of chronic cough.

Western medicine treats children's chronic cough according to medical history and etiology, the etiology is complex, the related scope is wide, some diseases can be clearly diagnosed only by cooperation of a plurality of departments, and corresponding treatment needs to be given by comprehensively considering the particularity of anatomy, physiology and immune function of children patients. Guidance for diagnosis and treatment of pediatric chronic cough by Chest in 2006^[4]The diagnosis and treatment of chronic cough in children is graded according to evidence level, effectiveness and recommended intensity according to a circulation medical method and according to the principle of the health and scientific grading system of the American Feverniers Association. Emphasizes the comprehensive and systematic evaluation of the chronic cough of the children, and observes and waits for the reevaluation of the nonspecific cough. Cough was sustained, treatment regimen was discussed with the parents, and experimental treatment was performed. The treatment is divided into dry cough, wet cough and damp cough, and the damp cough is mostly resistantAnd (4) performing hormone therapy. However, antibiotics are susceptible to drug resistance and possible risk of liver and kidney damage in long-term use.

Chronic wet cough with phlegm due to its cough belongs to the "phlegm cough" in TCM. There are also differences between "cough" and "cough", which is called "cough" in the integration of young children "where there is no phlegm or sound and there is phlegm or sound", and chronic wet cough with phlegm or sound. Jin Yuan Liu He Ji from Wen question machine in Yin Bao Ming Ji cloud "all cough caused by cold summer heat, dampness, wind and fire, except for damp disease phlegm which enters the stomach and stays in the lung, it is cough, indicating that phlegm is the main cause of cough. It can be seen that "phlegm" is closely related to the occurrence of wet cough. In addition, Su Wen Bing machine (seven Yi Bao Ming Ji) suggests that "cough is silent and voiced, lung qi is impaired and unclear, cough is silent and phlegm, and spleen dampness is phlegm" indicates that phlegm cough is responsible for both lung and spleen.

For children with chronic wet cough, the lung is vulnerable to impairment of lung qi after the lung feels exogenous pathogenic factors due to delicate and tender viscera and insufficient qi circulation of the children, and when the cough lasts for a long time, the child disease affects the mother, and the spleen soil is damaged, so that damp turbidity is generated internally; for example, when a person mostly eats a fat, sweet, thick and greasy food, the spleen fails to transport and transform, resulting in turbid phlegm; or the spleen fails to function normally and phlegm is retained inside the body, because cold drink tends to damage the middle-jiao yang, or the heat-clearing and toxicity-removing herbs are used for treating spleen dysfunction. The spleen is a source of phlegm generation, and if the transportation and transformation functions of the spleen cannot be recovered to normal, phlegm-dampness is difficult to transform and is dried on the lung, the lung is a phlegm storage device, phlegm-dampness is accumulated in the lung, lung qi is blocked, lung qi is disturbed and descended, cough is caused, and the lung is phlegm stagnation, so that the chronic wet cough is difficult to recover.

[ REFERENCE ] to

[1]Leonardi G S,Houthuijs D,Nikifomv B,etc.Respairatorysymptoms,bronchitis and asthma in children of central and eastern Europe[J].Eur Respire J,2002,20(4):890-898.

[2]Luyt D K,Burton P R,Simpson H.Epidemiological study of wheeze,doctor diagnosed asthma,and cough in preschool children in Lo icestemhire[J].Br Mad J,1993,3.6:1386-1390.

[3]Kefang Lai；Jiayu Pan；Ruchong Chen,etc.Epidemiology of cough in relation to China.Cough[J]:2013,9(1)

[4]Chang AB,GlombWB.Guidelines for evaluating chronic cough in pediatric：ACCP evidence——based clinical practice guidelines[J].Chest,2006,129(1):260-283.

Disclosure of Invention

In view of the above-mentioned deficiencies of the prior art, it is desirable to provide a Chinese medicinal composition for treating chronic wet cough in children, so as to improve cough symptoms, shorten the course of disease and effectively solve accompanying symptoms related to chronic cough patients. In addition, the invention also provides application of the traditional Chinese medicine composition.

According to the embodiment, the traditional Chinese medicine composition for treating chronic wet cough of children is prepared from the following raw material medicines in parts by weight: 6-15 parts of roasted aster, 6-15 parts of roasted radix stemonae, 6-15 parts of bighead atractylodes rhizome, 3-9 parts of platycodon grandiflorum, 3-9 parts of periostracum cicadae, 6-15 parts of cynanchum glaucescens, 3-6 parts of liquorice, 3-9 parts of pinellia ternate, 3-9 parts of dried orange peel and 3-9 parts of arisaema cum bile.

According to one embodiment, the traditional Chinese medicine composition for treating chronic wet cough in children comprises the following raw material medicines in parts by weight: 10 parts of roasted aster, 10 parts of roasted radix stemonae, 10 parts of bighead atractylodes rhizome, 6 parts of platycodon grandiflorum, 6 parts of periostracum cicada, 10 parts of rhizoma cynanchi stauntonii, 3 parts of liquorice, 6 parts of pinellia ternate, 6 parts of dried orange peel and 6 parts of arisaema cum bile.

According to one embodiment, in the traditional Chinese medicine composition for treating chronic wet cough in children, each raw material medicine is mixed with pharmaceutically acceptable pharmaceutical excipients to be prepared into tablets, pills, granules, powder, paste, powder, injection, aqueous solution, injection or nanometer materials.

The traditional Chinese medicine composition for treating chronic wet cough of children (hereinafter referred to as wet cough prescription for children) is prepared by the following steps: the infantile wet cough prescription is modified from the empirical prescription, namely infantile chronic cough prescription, and Erchen decoction.

The twelve five major subjects of the ' twelve five ' national administration of traditional Chinese medicine in 2012 bring ' chronic cough of children ' into the special disease research, pediatrics of our hospital also participates in the special disease group, and the clinical routes of children with chronic cough in regions are researched, so that the effective proved formula ' children ' chronic cough formula ' (honey-fried aster, honey-fried radix stemonae, white atractylodes rhizome, platycodon grandiflorum, cynanchum glaucescens, periostracum cicadae and liquorice) is summarized. The prescription is tailored to the prescription of relieving cough and dispersing from medical comprehension, original book cloud: for various cough, the whole formula is mild and mild, is not cold and hot, has no worry of over attack, and has great tendency of opening the door to expel the thief.

In the formula, the aster and stemona root are used as monarch drugs, and are sweet, bitter and warm in taste and enter lung meridian. The two medicines are warm but not dry, the aster is pungent and bitter in property and capable of dispersing and descending, and is specially used for relieving lung depression, and has the functions of reducing phlegm and stopping cough, the stemona root is sweet, moistening and bitter in property and capable of moistening lung and stopping cough.

The atractylodes, the platycodon root and the swallowwort rhizome are used as ministers. Bai Zhu is sweet and pungent in flavor and warm in nature. It enters spleen and stomach meridians. Has the effects of strengthening spleen, tonifying qi, eliminating dampness and inducing diuresis. It is said from Yi Xue Yi Yuan that it can remove dampness and benefit dryness, regulate the middle warmer and replenish qi, warm the middle warmer and remove dampness in the spleen and stomach. Bighead atractylodes rhizome is the essential drug for treating chronic cough in Xu-Xiao-Bao famous medical science in Haipai pediatrics, and is considered by Xu-Lao that chronic cough is long-term, lung and spleen qi deficiency and chronic cough is not cured, and the spleen needs to be treated, and Bighead atractylodes rhizome is used for the most part by 'Peengshenjin' method. Tantai pottery wine^[1]In the research on the prescription rule of the method for treating the chronic cough by the earth supplement method, the appearance frequency of the bighead atractylodes rhizome in the main medicine selection of the method for treating the chronic cough by the earth supplement method is up to 99.6 percent, so that the bighead atractylodes rhizome is the most core medicine of the method. Modern pharmacology also finds that the bighead atractylodes rhizome volatile oil has the effect of regulating gastrointestinal motility^[2](ii) a Atractylodis rhizoma also has antiinflammatory effect^[3]。

Platycodon root, radix Platycodi, bitter in flavor and neutral in nature, enters lung meridian, and has the effects of dispersing lung qi, relieving sore throat, eliminating phlegm and expelling pus. Bai Qian is pungent and bitter with slightly warm property, enters lung meridian, and has the actions of descending qi, resolving phlegm and relieving cough. The two herbs are combined together to disperse and descend one after another to recover the dispersing and descending functions of lung qi, so as to enhance the action of monarch herbs in relieving cough and resolving phlegm. Modern pharmacology finds that the platycodon grandiflorum water extract has good effects of relieving cough and reducing sputum^[4]Rhizoma Cynanchi Stauntonii has antitussive and expectorant effects^[5]The rhizoma Cynanchi Stauntonii alcohol extract has certain sedative and anti-inflammatory effects^[6]。

The cicada shell is used together, and has sweet, salty and cool property. It enters lung and liver meridians.It has effects of clearing qi, relieving cough, dispelling pathogenic wind and relieving cough. Modern pharmacological research finds that the cicada slough relieves inflammation by improving the content of leucocyte and improving the state of microscopic blood stasis, and can achieve the effects of relieving spasm and cough, eliminating phlegm and relieving asthma; all parts of periostracum Cicadae have tranquilizing, analgesic, and antipyretic effects^[7]。

So that the liquorice is sweet in taste and neutral in nature. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, eliminating phlegm and relieving cough, and harmonizing the drugs. Lidongyuan is used for moistening lung, and can treat lung deficiency and phlegm-eliminating wet cough. Sweet flavor belongs to earth entering spleen, excels in regulating the middle warmer, tonifying spleen and replenishing qi. In Shen nong Ben Cao Jing (Shen nong's herbal Jing) considers that Licorice root, radix Glycyrrhizae, because it can strengthen the muscles and bones, strengthen the muscles and muscles, strengthen the limbs, and tonify the spleen and stomach, the spleen and stomach are the acquired root, and it integrates the muscles and limbs, and it can strengthen the muscles and limbs by tonifying the spleen and qi. The compatibility of licorice root and white atractylodes rhizome can enhance the effect of white atractylodes rhizome in replenishing qi to invigorate the spleen.

Erchen decoction is prepared from pinellia ternate, dried orange peel and arisaema cum bile, which is a modified prescription of Erchen decoction. Ban Xia is combined with Chen Pi to dry dampness and resolve phlegm, and also to strengthen spleen and regulate qi. Arisaema cum bile is bitter and slightly pungent in flavor and cool in nature. It enters lung, liver and spleen meridians. It has the actions of drying dampness and resolving phlegm, and is stronger than ban Xia in warm and dry nature, so it can be used for stubborn phlegm cough and phlegm-damp stagnation, and it is combined with ban Xia to strengthen the actions of drying dampness and resolving phlegm. In Ben Cao Zheng, it is mentioned that the herbs are good at dispelling wind-phlegm and heat stagnation, and chronic wet cough with children may cause deficiency and recovery of the body and excessive inclusion due to chronic disease, and with arisaema cum bile, they can clear heat and resolve phlegm.

[ REFERENCE ] to

[1] Study on the prescription and drug rules of Tanshan and Bu-Guo method for treating chronic cough [ D ]. Guangzhou university of traditional Chinese medicine 2015.

[2] Effects of white atractylodes rhizome volatile oil on gastrointestinal function of mice [ J ] chinese journal of experimental prescriptions, 2009, 15 (8): 66-68.

[3] Wangwang, Yanna, Tatan, Tanshi, Linhongqiang, Dongqinghai, Lipingya, Liujin Ping, Largehead Atractylodes rhizome, pharmacological action and clinical application research progress [ J ] Gansu medicine, 2018,37(01):23-26.

[4] Remote beam, cough-relieving and phlegm-eliminating action research of platycodon grandiflorum water extract [ J ] chinese pharmacy 2011,22 (35): 3291-3292.

[5] Lianaihua, xuebaoyun, yangqing, etc. willow leaf is white and has antitussive, expectorant and anti-inflammatory effects [ J ] Chinese traditional medicine journal, 1996,21 (3): 173-175.

[6] Liuyang, Wangwang, Tang Shi Shu, Bai Qian modern research and development application prospect [ J ] northwest pharmaceutical journal, 2015,30(06): 768-.

[7] Zhaozaijia, Zhoushuan, Wangyu, etc. the research on the chemical components and pharmacological actions of periostracum cicadae [ J ] Jilin TCM, 2017,37(05):491-493.

The preparation method of the traditional Chinese medicine composition is not special, and the 7 medicinal materials are respectively weighed according to the weight ratio by adopting a common method in the field, decocted in water and taken once in the morning and at night.

Clinical research tests and application prove that the traditional Chinese medicine composition has the effects of improving the frequency and degree of cough, can improve symptoms such as running nose, phlegm in throat, nasal obstruction and the like, has no toxic or side effect, and can be used for treating chronic wet cough, including post-infection cough, upper airway cough syndrome, asthma complicated infection, persistent bacterial bronchitis and the like.

The traditional Chinese medicine action mechanism of the traditional Chinese medicine composition is as follows: aiming at pathogenesis pivots of phlegm-dampness obstructing lung and lung failing to disperse and descend of chronic wet cough, the traditional Chinese medicine composition has the effects of strengthening spleen and eliminating dampness, descending qi and moistening lung, relieving cough and reducing phlegm so as to improve cough symptoms and promote spleen and earth to strengthen transportation so as to prevent cough from persisting repeatedly.

The traditional Chinese medicine composition is prepared according to the theory of traditional Chinese medicine, from the perspective of traditional Chinese medicine, the internal organs of children are delicate and tender, the circulation of qi is not sufficient, the lung is vulnerable to impairment of lung qi after the lung feels exogenous pathogenic factors, and if the cough lasts for a long time, the child disease reaches the mother, and the spleen soil is damaged, so that the damp turbidity is endogenous; for example, when a person mostly eats a fat, sweet, thick and greasy food, the spleen fails to transport and transform, resulting in turbid phlegm; or the spleen fails to function normally and phlegm is retained inside the body, because cold drink tends to damage the middle-jiao yang, or the heat-clearing and toxicity-removing herbs are used for treating spleen dysfunction. The spleen is the source of phlegm generation, and if the transportation and transformation functions of the spleen can not be recovered to normal, phlegm-dampness is difficult to transform and is dried up in the lung, the lung is the phlegm storage device, phlegm-dampness is accumulated in the interior, and the lung qi is blocked, so that the lung fails to disperse and descend, and is cough, and the lung is phlegm stagnation, and is difficult to recover. Phlegm-dampness obstructing the lung-qi is the location of the pathogenesis hub. Therefore, the treatment of chronic wet cough should focus on the recovery of spleen function, and the treatment should be performed with the actions of drying dampness and resolving phlegm, so that there is no accumulation of phlegm-dampness.

The traditional Chinese medicine composition disclosed by the invention is proper in compatibility, has the effects of strengthening spleen, eliminating dampness, descending qi, moistening lung, relieving cough and reducing sputum, can be used for treating children with chronic wet cough which cannot be cured for a long time, can obviously relieve the cough symptoms in the daytime and at night, and can improve symptoms such as pharyngeal discomfort, nasal obstruction, watery nasal discharge, phlegm in throat, sweating, sleep, appetite, excrement and the like.

The traditional Chinese medicine composition is prepared from pure traditional Chinese medicines, has no toxic or side effect, and is easily accepted by children patients and family members.

Detailed Description

The invention will be further illustrated with reference to the following specific examples. These examples are to be construed as merely illustrative and not limitative of the remainder of the disclosure in any way whatsoever. After reading the description of the invention, one skilled in the art can make various changes and modifications to the invention, and such equivalent changes and modifications also fall into the scope of the invention defined by the claims.

In the following examples of the present invention, the experimental methods not specifically shown are all the experimental methods commonly used in the art.

In the following examples of the present invention, reagents not specifically shown are commercially available.

Example 1

Weighing 10g of fried aster, 10g of fried stemona root, 10g of largehead atractylodes rhizome, 3g of platycodon root, 3g of cicada shell, 10g of cynanchum glaucescens, 3g of liquorice, 6g of pinellia ternate, 6g of dried orange peel and 6g of arisaema cum bile, and decocting the raw materials in water according to a common method for later use. Is taken in the morning and evening.

Example 2

Weighing 15 g of fried aster, 15 g of fried stemona root, 15 g of largehead atractylodes rhizome, 9 g of platycodon root, 9 g of cicada shell, 15 g of cynanchum glaucescens, 6g of liquorice, 9 g of pinellia ternate, 9 g of dried orange peel and 9 g of arisaema cum bile, and decocting the raw materials in water according to a common method for later use. Is taken in the morning and evening.

Example 3

Weighing 5 g of fried aster, 5 g of fried stemona root, 5 g of largehead atractylodes rhizome, 1.5 g of platycodon root, 1.5 g of cicada shell, 5 g of cynanchum glaucescens, 1.5 g of liquorice, 3g of pinellia ternate, 3g of dried orange peel and 3g of arisaema cum bile, and decocting the raw materials in water according to a common method for later use. Is taken in the morning and evening.

Test examples

The action and effect of the medicament of the invention are proved by clinical tests.

One, general data.

The western medicine diagnosis refers to a diagnosis standard in 'Chinese children chronic wet cough diagnosis and therapist consensus' formulated by the Chinese medical society of science, subcontract and pneumology of 2019, and the traditional Chinese medicine diagnosis refers to a special disease path for pediatrics in the state traditional Chinese medicine administration and a diagnosis standard for phlegm-dampness lingering lung syndrome in 'a traditional Chinese medicine clinical path for pediatric chronic cough and an optimized diagnosis and treatment scheme' for the traditional Chinese medicine administration to perform case selection. The Shanghai medical university affiliated Longhua Hospital carries out clinical tests, and 115 cases are selected. 65 men and 50 women, and 1.30: 1. Age average

In 5.85 + -0.15 years of age, the difference between the cases in terms of sex, age, course of disease and disease condition is not significant and comparable.

And II, researching a method.

And (I) diagnosis standard.

(1) And (3) diagnosing the diseases in Western medicine:

according to ' Chinese expert consensus on diagnosis and treatment of chronic wet cough of children's disease ' in 2019

Continuous or repeated coughing for more than 4 weeks with expectoration or pronounced sputum whistling;

② cough is the only or major symptom.

(2) Traditional Chinese medicine syndrome diagnosis:

according to the Chinese medicine industry standard of the people's republic of China, namely the diagnosis and treatment effect standard of internal medicine diseases of traditional Chinese medicine

Syndrome of phlegm-dampness lingering in the lung (wet cough): cough with profuse and white sputum, deep and rumble phlegm in the throat, chest distress, lassitude, anorexia, pale red tongue with white and greasy coating, and slippery pulse.

(II) inclusion criteria.

The Chinese medicine composition accords with the Western medicine diagnosis standard and the Chinese medicine syndrome differentiation standard of the infantile chronic wet cough;

② the age is 1-14 years old, male and female;

and thirdly, the subject's family signs an informed consent and can cooperate with the informed consent.

(III) exclusion criteria.

1. Combined with other severe respiratory diseases: such as congenital tracheoesophageal fistula, congenital vascular malformation compressing airway, laryngotracheobronchial softening (or) stenosis, bronchopulmonary cyst, ciliary dyskinesia, mediastinal tumor, etc.;

2. patients with serious liver and kidney diseases, cardiovascular diseases, endocrine diseases, blood system diseases and nervous system diseases;

(ii) patients with other severe respiratory diseases: such as congenital tracheoesophageal fistula, congenital vascular malformation compressing airway, laryngotracheal bronchomalacia and/or stenosis, bronchopulmonary cyst, ciliary dyskinesia, mediastinal tumor, etc.;

② patients with serious liver and kidney diseases, cardiovascular diseases, endocrine diseases, blood system diseases and nervous system diseases.

③ those allergic to the test drugs;

fourthly, the patients are easy to be lost for visits according to the judgment of doctors.

And (IV) eliminating, falling off and stopping test standards.

After the inclusion, finding out the cases which do not meet the inclusion standard;

② the patients who can not judge the curative effect or the data is incomplete and the like which affect the curative effect judgment can not be judged according to the prescribed medication;

thirdly, allergic reaction, serious adverse events and complications occur, and researchers judge that the testers should be stopped;

fourthly, other diseases occur in the test process;

case of poor compliance subjects.

(V) treatment scheme.

The prescription for treating infantile wet cough by oral administration is as follows: 10g of roasted aster, 10g of roasted radix stemonae, 10g of bighead atractylodes rhizome, 6g of platycodon grandiflorum, 6g of periostracum cicada, 10g of rhizoma cynanchi stauntonii, 3g of liquorice, 6g of pinellia ternate, 6g of dried orange peel and 6g of arisaema cum bile.

Adopting granule of Sichuan New Green pharmaceutical science and technology development Limited company, age 1-3 years, 1/3 cases each time; 1/2 cases each time for 3-6 years old; the product is 6-14 years old, 1 case each time, and is administered twice daily. Is administered with warm water after meal for 2 weeks.

And (VI) observing the indexes.

Score of Cough symptoms (Cough Score, CS): according to the special disease path and the explanation of the traditional Chinese medicine of the State administration of traditional Chinese medicine for pediatrics, the traditional Chinese medicine clinical path and the optimized diagnosis and treatment scheme for the chronic cough of the children, parents of the children are used for judging and recording according to the cough symptoms 24 hours before the children by contrasting a score table: total score was day score + night score.

② Visual analog score for cough (VAS): the method adopts a linear scoring method, and the basic method is to use a moving scale with the length of about 10cm, one side of the moving scale is marked with 10 scales, the two ends of the moving scale are respectively a 0-degree end and a 10-degree end, the 0 scale represents no symptom, and the 10 scale represents the most severe cough degree of a patient. The larger the number, the more severe the cough, for longitudinal comparison before and after treatment.

③ integration of syndromes of traditional Chinese medicine: the improvement of the Chinese medicine symptom integrals of throat, nasal obstruction, running nose, phlegm in throat, sweating, sleep, appetite and stool is observed.

Quality of life assessment: age 0-6 using a parental agent Cough Specific Quality of Life questionnaire (Parent-proxy Cough-Specific Quality of Life (PC-QoL) questonnaire); LCQ Questionnaire ((Leicester Cough questonnaire) is used for 6-14 years old

(VII) treatment effect evaluation criteria.

According to the Chinese medicine special disease path and the release of the Chinese medicine special disease path and the optimized diagnosis and treatment scheme of the State administration of traditional Chinese medicine "

The cough symptom score is taken as the evaluation standard of the curative effect. And (3) healing: cough symptoms completely disappeared (down to score 0 after treatment). The effect is shown: cough symptoms are significantly reduced (6-9 points less after treatment than before treatment). The method has the following advantages: cough symptoms were reduced (2-5 points less after treatment than before treatment). And (4) invalidation: the cough symptoms did not improve or worsen. (≦ 1 min)

And thirdly, obtaining a result.

1. And (4) evaluating the total curative effect of the disease.

Through statistical analysis, 115 wet cough children patients are cured by 28 children wet cough treatment in 14 days, the obvious effect is 11 children wet cough patients are cured, the effective effect is 62 children wet cough patients are cured, the ineffective effect is 14 children wet cough patients are cured, and the total effective rate is 87.8 percent (see table 1)

TABLE 1 Total curative effect evaluation of infantile chronic wet cough

2. The main therapeutic index.

(1) Cough symptom score.

(ii) total score of cough symptoms:

the infantile wet cough prescription for treating chronic cough children has statistical significance of the difference before and after treatment through Mann-Whitney U rank sum test, and P is less than 0.01. After treatment is better than before treatment. (see Table 2)

TABLE 2 Total score comparison of cough symptoms before and after treatment for children with chronic wet cough

② integration of cough symptom in daytime.

The infantile wet cough prescription for treating chronic cough children has statistical significance of differences before and after treatment through Mann-Whitney U rank sum test, and P is less than 0.01. After treatment is better than before treatment. (see Table 3)

TABLE 3 interday cough symptom score comparison of children with chronic wet cough before and after treatment

③ integration of cough symptom at night.

The infantile wet cough prescription for treating chronic cough children has statistical significance of differences before and after treatment through Mann-Whitney U rank sum test, and P is less than 0.01. After treatment is better than before treatment. (see Table 4)

TABLE 4 comparison of daytime cough integral of children with chronic wet cough before and after treatment

(2) Cough visual simulation score.

The children wet cough prescription treats children with chronic cough, the visual simulation score of cough before and after treatment is tested by Mann-Whitney U rank sum, the difference before and after treatment has statistical significance, and P is less than 0.01. After treatment is better than before treatment. (see Table 5)

TABLE 5 visual simulation score comparison of cough in children with chronic wet cough before and after treatment

3. Chinese medicine syndrome curative effect index results.

(1) And (4) evaluating the total curative effect of the traditional Chinese medicine symptoms.

For the improvement of symptoms, the infantile wet cough prescription cures 28 cases, has obvious effect of 65 cases, has 8 cases and 14 cases, has no effect, and has the total effective rate of 87.2 percent (see table 6)

TABLE 6 Total curative effect evaluation of Chinese medicine symptoms of children with chronic wet cough

(2) The curative effect of traditional Chinese medicine symptoms.

Through statistical analysis, 115 cases of children with wet cough have improved treatment on aspects of posterior pharyngeal portion, nasal obstruction, watery nasal discharge, phlegm in throat, sweating, sleeping, appetite, stool and the like by 14 days of treatment of the children with wet cough formula compared with before treatment. (see Table 7)

TABLE 7 comparison of Chinese medicine symptoms after treatment of infantile chronic wet cough

4. And (5) evaluating the life quality of children with chronic wet cough.

(1) The children's wet cough prescription can improve the life quality of children with chronic wet cough of 1-6 years old.

Through statistical analysis, 64 children with wet cough in 115 cases, wherein the children with 1-6 years old, the 64 children with chronic wet cough are analyzed for life treatment.

Comparing the total quality of life.

TABLE 8.1-6 years old Total score comparison of quality of life

The difference of the general quality of life before and after the treatment is tested by the wilcoxon rank sum has statistical significance, P is less than 0.01, and the treatment is better than the treatment before.

② comparing physiological components.

TABLE 9.1-6 years old quality of life physiological ratio comparison

The physiological score and difference of the quality of life before and after the treatment are tested by the wilcoxon rank sum, and the P is less than 0.01. After treatment is better than before treatment.

And thirdly, psychological score comparison.

TABLE 10.1-6 years old life quality and mental ratio

Before and after the treatment by wilcoxon rank sum test, the difference of the psychology of the life quality has statistical significance, and P is less than 0.05.

After treatment is better than before treatment.

And fourthly, social score comparison.

TABLE 11.1-6 years old quality of life social score comparison

The difference of the social classification of the quality of life before and after the treatment is tested by the wilcoxon rank sum and has statistical significance, and P is less than 0.01.

After treatment is better than before treatment.

(2) The children's wet cough prescription can improve the life quality of children with chronic wet cough of 6-14 years old.

Through statistical analysis, 51 of 115 wet cough children, 6-14 years old, were analyzed for life treatment of the 51 chronic wet cough children.

Comparing the total quality of life.

TABLE 12.6-14 years old Total score comparison of quality of life

The difference of the general quality of life before and after the treatment is tested by the wilcoxon rank sum has statistical significance, and P is less than 0.01. After treatment is better than before treatment.

② comparing physiological components.

TABLE 13.6-14 years old physiological score comparison of quality of life

And thirdly, psychological score comparison.

TABLE 14.6-14 years old quality of life psychology score comparison

Before and after the treatment by wilcoxon rank sum test, the difference of the psychology of the life quality has statistical significance, and P is less than 0.01.

After treatment is better than before treatment.

And fourthly, social score comparison.

TABLE 15.6-14 years old quality of life social comparison

After treatment is better than before treatment.

And fourthly, concluding.

In conclusion, the traditional Chinese medicine composition can effectively relieve the symptoms and the life quality of the chronic wet cough, and can be used for treating the chronic wet cough of children.

Claims

1. The traditional Chinese medicine composition for treating chronic wet cough of children is characterized by being prepared from the following raw material medicines in parts by weight: 6-15 parts of roasted aster, 6-15 parts of roasted radix stemonae, 6-15 parts of bighead atractylodes rhizome, 3-9 parts of platycodon grandiflorum, 3-9 parts of periostracum cicadae, 6-15 parts of cynanchum glaucescens, 3-6 parts of liquorice, 3-9 parts of pinellia ternate, 3-9 parts of tangerine peel and 3-9 parts of arisaema cum bile.

2. The traditional Chinese medicine composition for treating chronic wet cough of children as claimed in claim 1, wherein the weight ratio of each raw material medicine is respectively: 10 parts of roasted aster, 10 parts of roasted radix stemonae, 10 parts of bighead atractylodes rhizome, 3 parts of platycodon grandiflorum, 3 parts of periostracum cicada, 10 parts of rhizoma cynanchi stauntonii, 3 parts of liquorice, 6 parts of pinellia ternate, 6 parts of dried orange peel and 6 parts of arisaema cum bile.

3. The Chinese medicinal composition according to claim 1 or 2, wherein the pharmaceutical composition is mixed with pharmaceutically acceptable pharmaceutical excipients to prepare tablets, pills, granules, powder, paste, powder, injection, aqua, injection or nano-materials.

4. Use of the Chinese medicinal composition of claim 1 or 2 or 3 for the preparation of a medicament for the treatment of chronic wet cough in children.

5. Use of the Chinese medicinal composition of claim 1,2 or 3 for the preparation of a medicament for treating chronic cough in children.