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CN117357453A - Skin oil control composition and application thereof - Google Patents

Skin oil control composition and application thereof Download PDF

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Publication number
CN117357453A
CN117357453A CN202311400512.2A CN202311400512A CN117357453A CN 117357453 A CN117357453 A CN 117357453A CN 202311400512 A CN202311400512 A CN 202311400512A CN 117357453 A CN117357453 A CN 117357453A
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Prior art keywords
oil control
parts
extract
control composition
hair
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Inventor
李涛
刘梦珍
黄志坚
谭伟雄
梁志彬
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Guangzhou Datang Cosmetics Co ltd
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Guangzhou Datang Cosmetics Co ltd
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Priority to CN202311400512.2A priority Critical patent/CN117357453A/en
Publication of CN117357453A publication Critical patent/CN117357453A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/008Preparations for oily hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to the field of daily chemicals, and discloses a skin oil control composition which has a synergistic inhibition effect on 5 alpha-reductase in skin tissues so as to inhibit sebum secretion of sebaceous glands, and consists of components of a saw palmetto extract, a astragalus extract and a coltsfoot leaf extract; the hair oil control composition is applied to hair oil control compositions and consists of a skin oil control composition and an auxiliary oil control auxiliary agent; the auxiliary oil control auxiliary agent consists of oligomeric arginine chitosan and hydrolyzed sodium hyaluronate; the shampoo comprises the following main components: hair oil control compositions, matrix cleaners, amino acid surfactants, co-surfactants, thickeners, scalp conditioning agents, pearling agents. The active ingredients of the product can form a synergistic effect, effectively inhibit 5 alpha-reductase, further inhibit the secretion of sebaceous gland grease in skin tissues, and achieve the effects of long-acting maintenance of scalp health and hair cleanness and beauty.

Description

Skin oil control composition and application thereof
Technical Field
The invention relates to the field of daily chemicals, in particular to a skin oil control composition and application thereof.
Background
Sebum plays a very important role in maintaining scalp and hair health, but excessive sebum can form oily scalp to cause dandruff, itching and other symptoms, and simultaneously can accelerate the oil-out and collapse rate of hair to influence the air quality and beauty of people. With the acceleration of the current society life rhythm, the unbalance of the diet structure and the increase of life pressure, the problem of hair oil output is more and more common. The sebaceous gland cells in human skin are in a state of secreting grease at any time, wherein one of important factors affecting sebum secretion of the sebaceous gland is 5 alpha-reductase activity.
The traditional oil control hair washing agent mainly adopts the method of reducing the content of silicone oil, grease and conditioning agent in shampoo or increasing the content of surfactant so as to enhance the cleaning effect of grease, thereby achieving the oil control effect and lacking in deeper regulation of scalp oil. The reduction of the oil content in the shampoo can cause the problems of hair dehydration, frizziness, dryness and the like, and can also cause sebaceous glands to secrete more oil so as to further influence the health of scalp.
In recent years, the application of herbal medicine components in daily chemical industry is more and more widespread, wherein more traditional Chinese medicine components including ginger, polygonum multiflorum, saw palmetto, astragalus and the like are applied, and active substances of the herbal medicine components can generate nursing effects on scalp and hair in multiple aspects.
The prior art studies show that: saw palmetto has 5 alpha-reductase inhibiting activity and seborrheic alopecia preventing effect, so that sebum secretion can be inhibited.
Patent number KR1020140011239A discloses that crude extracts, polar solvent-soluble extracts or nonpolar solvent-soluble extracts of Astragalus have activity of 5 alpha-reductase expression inhibition. Astragalus root, radix astragali is a tonic herb in Chinese medicine, but it is good at moving, moving up and down, both inside and outside, and has the action of promoting hair growth. Qi can be supplemented and the exterior can be fixed on the exterior, and healthy qi is outwards encouraging to support toxin and be externally penetrated; internal tonifying middle-qi to raise yang and collapse, so that qi-solid and collapse is removed; upward qi-ascending water self-descending to tonify qi, promote diuresis, tonify qi and promote blood circulation. The radix astragali extract can supplement nutrition for hair, and promote blood circulation. Wherein, the application of saw palms or astragalus in shampoo mainly uses the additive with various plant components to solve the problem of alopecia of users. The shampoo has the problems of excessive traditional Chinese medicine components in the formula and complex preparation process, and the shampoo is a daily washing product, and active substances in the formula are difficult to reside, so that the shampoo is not easy to exert the function of fully controlling oil.
Although the prior art discloses that a plurality of components can inhibit sebaceous glands from secreting grease, how to more effectively inhibit sebaceous glands from secreting sebum and solve the problem that scalp grease is excessive so as to protect hair health, clean and beautiful is still a difficult problem in the field of daily chemicals.
Disclosure of Invention
Aiming at the defects of the prior art, the invention solves the technical problems of better inhibiting sebum secretion of sebaceous glands and solving the problem of excessive scalp grease so as to achieve the effects of scalp health and hair cleaning and beauty.
In order to solve the technical problems, the technical scheme provided by the invention is that the skin oil control composition has a synergistic inhibition effect on 5 alpha-reductase in skin tissues, so as to inhibit sebum secretion of sebaceous glands, and the skin oil control composition comprises the following components in parts by mass:
4-5 parts of saw palmetto extract;
3-4 parts of astragalus extract;
1-3 parts of coltsfoot leaf extract.
The saw palmetto extract is a combination of a fat-soluble extract and an alcohol-water extract of saw palmetto;
the astragalus extract is an alcohol-water extract;
the coltsfoot leaf extract is an alcohol-water extract.
In order to solve the technical problems, the other technical scheme provided by the invention is that the hair oil control composition containing the skin oil control composition comprises the following components in parts by mass:
1-10 parts of skin oil control composition;
1-5 parts of auxiliary oil control auxiliary agent;
the auxiliary oil control auxiliary agent consists of the following components in parts by mass:
1-3 parts of oligo-arginine chitosan;
1-8 parts of a composition for hydrolyzing sodium hyaluronate.
The molecular weight of the hydrolyzed sodium hyaluronate is less than or equal to 10kDa.
The oligomeric arginine is an artificially synthesized high-efficiency cationic membrane penetrating peptide, can carry various substances into cells or carry out intercellular transmission, and simultaneously can adsorb a large amount of positive charges on the surface of hair. The oligomeric arginine chitosan has the effect of promoting the transdermal absorption of small molecular substances and also has a certain slow release effect.
Sodium hyaluronate is an inherent biological substance of skin, has a good moisturizing effect, and small sodium hyaluronate can permeate into the epidermis layer of the skin to promote the supply of skin nutrition and the excretion of waste.
In order to solve the technical problems, the invention provides a shampoo containing the hair oil control composition, which comprises the following components:
0.5 to 4.5 parts of hair oil control composition;
3.5 to 10.8 portions of matrix cleaner;
6.5 to 15.0 portions of amino acid surfactant;
3.5 to 5.8 portions of auxiliary surfactant;
0.3 to 1.0 part of thickener;
0.5 to 1.5 portions of scalp conditioner;
0.5 to 1.2 portions of pearling agent;
0.4 to 2.0 portions of other auxiliary agents;
a proper amount of pH regulator;
and proper amount of deionized water.
Further, the matrix cleanser is at least one of fatty alcohol polyether sulfate, monoalkyl sulfate and fatty acyl methyl taurate; preferably, the cleaning agent is a fatty alcohol polyether sulfate. Still further, the fatty alcohol polyether sulfate is sodium laureth sulfate.
The amino acid surfactant is sodium lauroyl glutamate;
the auxiliary surfactant is at least one of fatty acyl amphoacetate, fatty acyl propyl betaine and fatty amide hydroxypropyl sulfobetaine; preferably, the cosurfactant is fatty acyl propyl betaine, and further, the fatty acyl propyl betaine is lauroyl propyl betaine.
The thickener is at least one of carbomer, ammonium chloride, sodium chloride and sodium carboxymethyl cellulose;
the scalp conditioner is at least one of amino acids, allantoin, nicotinamide and keratin;
the pearling agent is at least one of glycol distearate and glycerol monostearate;
the other auxiliary agent is at least one of antistatic agent, preservative and essence.
Further, the antistatic agent is at least one of polyquaternium and guar gum hydroxypropyl trimethyl ammonium chloride; the preservative is at least one of phenoxyethanol, ethylhexyl glycerol, sodium benzoate, methylparaben and ethylparaben.
The beneficial effects are that:
(1) The saw palmetto extract, the astragalus extract and the coltsfoot leaf extract are combined according to a specific proportion, so that a synergistic effect is formed among the active ingredients of the components, 5 alpha-reductase can be effectively inhibited, and secretion of sebaceous gland grease in skin tissues is further inhibited;
(2) By compounding the oligo-arginine chitosan and the sodium hyaluronate in the hair oil control composition, the effective ingredients in the saw palmetto extract, the astragalus extract and the coltsfoot leaf extract are fully absorbed by the scalp, so that the synergistic oil control effect is exerted in scalp tissues, and the effects of long-acting maintenance of scalp health and hair cleanness and beauty are achieved.
Drawings
FIG. 1 is a schematic representation of skin oil content of different compositions at different times;
FIG. 2 is a schematic of scalp fat content for different time periods of short use of different shampoos;
figure 3 is a schematic of scalp fat content for different time periods of prolonged use of different shampoos.
Detailed Description
The following description of the embodiments of the invention is given by way of illustration and not limitation.
The plant extracts in the following examples and comparative examples can be obtained by basic extraction methods, and the remaining raw materials, reagents or apparatuses can be obtained from conventional commercial sources or by known methods, unless otherwise specified.
1. Skin oil control composition examples
Example 1
The skin oil control composition comprises the following components in parts by mass:
4 parts of saw palmetto extract;
4 parts of astragalus extract;
1 part of coltsfoot leaf extract.
Example 2
The skin oil control composition comprises the following components in parts by mass:
5 parts of saw palmetto extract;
3 parts of astragalus extract;
3 parts of coltsfoot leaf extract.
Example 3
The skin oil control composition comprises the following components in parts by mass:
4.5 parts of saw palmetto extract;
3.5 parts of astragalus extract;
2 parts of coltsfoot leaf extract.
A skin oil control composition of the above examples 1 to 3 was prepared as follows:
(1) Pulverizing a certain amount of saw palms, radix astragali and folium Farfarae at high speed, sieving with 200 mesh sieve, extracting saw palms powder with 70% ethanol, filtering to separate filtrate and residue, and extracting residue with ethyl acetate for the second time to obtain fat-soluble saw palms extract; wherein the filtrate is concentrated to obtain alcohol water saw palmetto extract, and the obtained fat-soluble saw palmetto extract and alcohol water saw palmetto extract are mixed to obtain saw palmetto extract.
(2) Extracting radix astragali powder and folium Farfarae powder with 70% ethanol respectively, collecting the extractive filtrate, and concentrating to obtain radix astragali extract and folium Farfarae extract.
(3) Mixing saw palmetto extract, radix astragali extract and folium Farfarae extract to obtain skin oil control composition.
2. Examples of hair oil control compositions
Example 4
The hair oil control composition comprises the following components in parts by mass:
4 parts of saw palmetto extract;
4 parts of astragalus extract;
1 part of coltsfoot leaf extract;
1 part of a skin oil control composition;
and 5 parts of auxiliary oil control auxiliary agent.
Example 5
The hair oil control composition comprises the following components in parts by mass:
5 parts of saw palmetto extract;
3 parts of astragalus extract;
3 parts of coltsfoot leaf extract;
10 parts of skin oil control composition;
auxiliary oil control auxiliary agent 1 part.
Example 6
The hair oil control composition comprises the following components in parts by mass:
4.5 parts of saw palmetto extract;
3.5 parts of astragalus extract;
2 parts of coltsfoot leaf extract;
5 parts of a skin oil control composition;
3 parts of auxiliary oil control auxiliary agent.
A hair oil control composition of examples 4 to 6 was prepared as follows:
(1) Adding a proper amount of oligoarginine into a certain amount of coltsfoot leaf extract for standby;
(2) Mixing and stirring a certain amount of saw palmetto extract and radix astragali extract according to a certain proportion, and homogenizing at 5000-10000rpm for more than 5 min;
(3) After homogenization, adding a certain amount of hydrolyzed sodium hyaluronate powder, and stirring uniformly;
(4) Dripping folium Farfarae extract containing oligo-arginine chitosan under stirring, and stirring for more than 30min to obtain hair oil control composition.
Comparative examples 1 to 4
Unlike examples 1 to 3, the plant extract component in the comparative example was a single solvent extract of a single plant. Specific plant extracts are shown in table 1 below.
TABLE 1
Comparative examples 5 to 7
Unlike examples 1 to 3, the plant extract component in the comparative example was a combination of two plant extracts. Specific plant extract compositions and parts ratios thereof are shown in table 2 below.
TABLE 2
Comparative example Plant extracts Mass fraction ratio
Comparative example 5 Saw palmetto extract: astragalus mongholicus extract 1:1
Comparative example 6 Saw palmetto extract: coltsfoot leaf extract 1:1
Comparative example 7 Astragalus extract: coltsfoot leaf extract 1:1
3. Efficacy test of the composition
Inhibition of 5 alpha-reductase Activity
The plant extracts of the above examples and comparative examples were subjected to pretreatment to obtain pretreated sample solutions, wherein the effective concentration of the single extract or the extract composition solution was 1.0%, 20uL of each of the sample solution and the negative control (physiological saline) was taken, and the pretreatment was carried out in an enzyme reaction system for 10min at 37 ℃ under the condition of ph=6.0. The absorbance was measured at 340nm using a UV-2800 UV-visible spectrophotometer, available from Shanghai instruments, you Nike, and the enzyme activity was calculated by taking the average of the absorbance three times.
Enzyme activity u= (absorbance change a/0.01 reaction time t) dilution factor D.
The enzyme activity results of 5 a to reductase are shown in table 3 below:
TABLE 3 Table 3
As can be seen from Table 3, compared with the negative control experiment, the compositions of the saw palmetto extract, the astragalus extract and the coltsfoot leaf extract in examples 1 to 3 have lower enzyme activity values, i.e. the compositions have remarkable inhibition effect on 5 alpha-reductase. Comparing the effect of the plant extracts in example 1 and comparative examples 1 to 4, it can be found that the enzyme activity values of the experimental group to which the three plant extracts are added alone are lower than those of the negative control group, that is, the three plant extracts have the inhibition effect on 5 alpha-reductase, wherein the effect of the composition of the saw palmetto extract, the astragalus extract and the coltsfoot leaf extract is superior to that of the fat-soluble saw palmetto extract, the alcohol-water saw palmetto extract, the astragalus extract and the coltsfoot leaf extract.
Comparing the enzyme activity values after the plant extracts in example 1 and comparative examples 5 to 7, it can be found that the effect of the saw palmetto extract, the astragalus extract, and the coltsfoot leaf extract composition is superior to that of the saw palmetto extract and the astragalus extract composition, and is significantly superior to that of the astragalus extract and the coltsfoot leaf extract composition. Comparing the test results of the test samples in example 1 and examples 4 to 6, it was found that the enzyme activity value was not significantly changed by adding the auxiliary oil control adjuvant.
Therefore, the single extracts of the saw palms, the astragalus and the coltsfoot leaves are taken as 5 alpha-reductase inhibition active ingredients and have certain action and effect, wherein the action and effect of the saw palms extract are superior to that of the astragalus extract, the action and effect of the saw palms extract are superior to that of the coltsfoot leaves extract, and the inhibition effect of the saw palms extract on 5 alpha-reductase can be obviously improved after the three plant extracts are combined. The auxiliary oil control auxiliary agent does not show obvious effect in an in-vitro 5 alpha-reductase activity inhibition experiment of the oil control composition.
(II) skin oil control experiment
The plant extracts of the above examples and comparative examples were subjected to pretreatment to obtain a pretreated sample solution, wherein the effective concentration of the single extract or the extract composition solution was 1.0%, and the blank group was purified water without any extract. The forehead skin with more oil produced by 33 testers is selected for testing, and the average value of the fat content of the skin of three people is tested for each three people. After a tester performs simple face cleaning, 3.0cm of absorbent cotton is fully soaked in the extract solution or purified water, and after the forehead skin is pasted for 10min, the grease content of test areas 1h, 3h, 5h, 7h and 9h is respectively tested by a multifunctional skin tester. The principle of the equipment is that the probe contains a extinction adhesive tape, the transparency of the adhesive tape is increased after the adhesive tape adsorbs grease, the content of scalp grease can be reflected through the light transmission quantity of the probe, and the measured value unit is mug/cm 2 . The skin oil content was obtained at different times as shown in fig. 1:
as can be seen from FIG. 1, the skin oil contents after 1h, 3h, 5h, 7h and 9h of the skin of the blank group and the comparative examples 1 to 7 were compared, and the skin oil contents of the added plant extracts were lower than those of the control group, but the effect was mainly that the skin oil contents could be higher after more than 5h before 5 h. Examples 1 to 3 and comparative examples 1 to 4 were compared, wherein the skin oil content in examples 1 to 3 was significantly lower than that in comparative examples 1 to 4. Further comparing the skin oil content of example 1 and comparative examples 4 to 7, it was found that the skin oil content of example 1 after 3 hours was significantly lower than the skin oil content at the corresponding time in comparative examples 4 to 7. In comparative examples 4 and 1, it can be found that after the oil control composition is compounded with the auxiliary oil control additive, the oil content value of the skin is obviously reduced for 5 hours and later, and the oil content of the skin is reduced by 43% compared with that of a blank control group at 9 hours.
Therefore, the control effect of the composition of the saw palmetto extract, the astragalus extract and the coltsfoot leaf extract on the oil extraction condition of the skin is obviously better than that of the composition of the three plant extracts when the three plant extracts are independently acted, and is further better than that of the composition of the plant extracts obtained after the three plant extracts are compounded in pairs. The oil control agent is characterized in that on one hand, the composition of the saw palmetto extract, the astragalus extract and the coltsfoot leaf extract has obvious oil control effect, and can effectively control the oil output of the skin after the action. Furthermore, the oligomeric arginine chitosan and the sodium hyaluronate auxiliary agent are compounded in the three plant extraction compositions, so that the synergistic effect can be achieved, and the long-acting oil control effect of the compositions can be fully exerted.
4. Shampoo examples
Example 7
A shampoo comprising a hair control composition comprising the following components:
0.5 parts of hair oil control composition;
10.8 parts of laureth sodium sulfate;
6.5 parts of sodium lauroyl glutamate;
5.8 parts of lauroyl propyl betaine;
0.3 parts of carbomer;
1.5 parts of keratin;
0.5 parts of ethylene glycol distearate;
2.0 parts of phenoxyethanol;
a proper amount of pH regulator;
and proper amount of deionized water.
Example 8
A shampoo comprising a hair control composition comprising the following components: 4.5 parts of a hair oil control composition;
3.5 parts of laureth sodium sulfate;
15.0 parts of sodium lauroyl glutamate;
3.5 parts of lauroyl propyl betaine;
1.0 parts of carbomer;
0.5 parts of keratin;
1.2 parts of ethylene glycol distearate;
0.4 parts of phenoxyethanol;
a proper amount of pH regulator;
and proper amount of deionized water.
Example 9
A shampoo comprising a hair control composition comprising the following components:
2 parts of hair oil control composition;
5 parts of laureth sodium sulfate;
12 parts of sodium lauroyl glutamate;
4 parts of lauroyl propyl betaine;
0.5 parts of carbomer;
1 part of keratin;
0.8 parts of ethylene glycol distearate;
1 part of phenoxyethanol;
a proper amount of pH regulator;
and proper amount of deionized water.
Comparative example 8
A shampoo comprising a skin oil control composition comprising the following components:
0.5 parts of skin oil control composition;
10.8 parts of laureth sodium sulfate;
6.5 parts of sodium lauroyl glutamate;
5.8 parts of lauroyl propyl betaine;
0.3 parts of carbomer;
1.5 parts of keratin;
0.5 parts of ethylene glycol distearate;
2.0 parts of phenoxyethanol;
a proper amount of pH regulator;
and proper amount of deionized water.
A shampoo containing the hair or skin oil control composition of examples 7-9 and comparative example 8 was prepared as follows:
(1) Adding deionized water, matrix cleaner, amphoteric surfactant, amino acid surfactant and carbomer into water, heating to 80deg.C, dissolving, and dispersing;
(2) Sequentially adding hydroxypropyl guar gum hydroxypropyl trimethyl ammonium chloride and glycol distearate, stirring and dissolving uniformly, and cooling to 45 ℃;
(3) Adding keratin, polydimethylsiloxane, an oil control composition and phenoxyethanol, and stirring and dissolving uniformly to obtain a finished product;
(4) The pH is adjusted to between 4.0 and 6.5.
Comparative example 9
A shampoo comprising the following components:
9.8 parts of laureth sodium sulfate;
8.2 parts of sodium lauroyl glutamate;
2.4 parts of lauroyl propyl betaine;
0.2 parts of carbomer;
0.8 parts of ethylene glycol distearate;
0.3 parts of keratin;
0.05 part of polyquaternium-7;
0.5 part of phenoxyethanol;
0.2 parts of essence;
a proper amount of pH regulator;
and proper amount of deionized water.
Comparative example 10
A shampoo comprising the following components:
9.8 parts of laureth sodium sulfate;
8.2 parts of sodium lauroyl glutamate;
2.4 parts of lauroyl propyl betaine;
0.2 parts of carbomer;
0.8 parts of ethylene glycol distearate;
0.5 parts of polydimethylsiloxane;
0.3 parts of keratin;
0.05 part of polyquaternium-7;
0.5 part of phenoxyethanol;
0.2 parts of essence;
a proper amount of pH regulator;
and proper amount of deionized water.
4. Evaluation of shampoo efficacy
Test of short-term oil control effect
Several oily hair volunteers were recruited, and after one hair wash, the shampoos of the formulations of examples 6 to 8 and comparative examples 8 to 10 were tried out, and the scalp oils were tested for 8h, 24h, 48h, and 72 h. The test scoring index and test data are shown in table 4 below.
The detection method of the grease content comprises the following steps: the adopted detection equipment is a multifunctional skin tester, the equipment principle is that a probe contains a extinction adhesive tape, the transparency of the adhesive tape is increased after the adhesive tape adsorbs grease, the content of scalp grease can be reflected through the light transmission quantity of the probe, the number of sampling points is at least three each time (left and right head tops and head top positions), the average value is taken as a measured value, and the measured value unit is mug/cm 2 The measured values are shown in table 4 below.
TABLE 4 Table 4
As can be seen from table 4 above and fig. 2, comparative examples 6 to 9 and comparative examples 8 to 10 show that the oil content of the scalp was not significantly different before the testers used the shampoo formulations of each experimental group for 8 hours, whereas the oil content of the scalp was significantly lower than that of the testers used the shampoo formulations containing the combination of saw palmetto extract, astragalus extract, and coltsfoot extract after 8 hours. Wherein examples 6-8 also show a relatively low scalp oil output after 8 hours as compared to comparative example 8.
Therefore, the oil output of the scalp can be effectively inhibited by adding the composition of the saw palmetto extract, the astragalus extract and the coltsfoot leaf extract into the shampoo formula, so that the shampoo oil control effect is achieved, and the oil control effect of the shampoo added with the hair oil control composition formula can be further improved by adding the oligomeric arginine chitosan and the sodium hyaluronate auxiliary agent.
(II) evaluation of permanent oil control Effect and hairiness Effect
Several oily hair volunteers were recruited, shampoo formulations of examples 6-8 and comparative examples 8-10 were tried out, and after 28 days of use, 8h, 24h, 48h, 72h scalp grease changes were tested, and the data are shown in table 5. And scoring the hair quality 72 hours after shampooing, wherein the hair quality scoring index and the test data are as follows:
scoring index:
the greasy feel was evaluated by scoring 1-5 points, 1 point for very oily, 2 points for oily, 3 points for general, 4 points for good, and 5 points for good. The degree of dryness was evaluated by scoring 1 to 5 points, 1 point indicating very dry, 2 points indicating dry, 3 points indicating general, 4 points indicating good, and 5 points indicating good. The results were averaged for each group, with one decimal point retained, and the results are shown in table 6.
TABLE 5
Scalp fat content Example 6 Example 7 Example 8 Comparative example 8 Comparative example 9 Comparative example 10
8h 24.6 23.4 20.8 26.5 44.2 50.6
24h 42.2 42.3 40.4 46.6 81.8 90.2
48h 68.7 68.9 66.8 70.1 101.4 120.6
72h 75.5 72.6 70.4 95.9 121.7 143.4
As can be seen from the above tables 5 and 3, the scalp grease changes of the testers after using the shampoo formulations of each experimental group were continuously measured for 28 days by the testers, and after 8 hours, 24 hours, 48 hours and 72 hours, the scalp grease content of the testers in examples 6 to 8 was significantly lower than that of the testers in comparative examples 8 to 10, wherein the scalp grease content of examples 6 to 8 after 48 hours was relatively lower, and the increasing trend of the scalp grease content was significantly slower.
Therefore, the saw palm extract, the astragalus extract and the coltsfoot leaf extract composition are added into the shampoo formula, so that the oil yield of the scalp can be obviously controlled after long-term use, and the oligomeric arginine chitosan and the sodium hyaluronate oil control auxiliary agent are further compounded into the shampoo, so that the growth trend of scalp grease can be effectively controlled, the oil-water balance of the scalp is maintained, and the condition of the subsequent scalp oil discharge aggravation caused by excessively clean shampoo is avoided.
TABLE 6
Hair quality Example 6 Example 7 Example 8 Comparative example 8 Comparative example 9 Comparative example 10
Degree of greasiness 4 5 4 3 4 1
Degree of dryness 5 4 5 5 2 5
As can be seen from table 6 above, comparing examples 6 to 8 with comparative examples 8 to 10, it can be seen that the test subjects continued to test the degree of greasiness and dryness of the hair after using the shampoo formulations of each experimental group for 28 days, and that examples 6 to 8 can effectively control the degree of greasiness of the hair without causing excessive dryness of the hair after using the shampoo formulations of different groups for 72 hours. Therefore, it is known that the addition of the hair oil control composition to the shampoo formulation can effectively inhibit the amount of hair oil from the scalp for a long period of time, and can avoid the condition of dry hair caused by the selection of excessively clean shampoo or the subsequent hair oil from the selection of shampoo components containing silicone oil.
Therefore, the oil control composition of the saw palmetto extract, the astragalus extract and the coltsfoot leaf extract composition compounded with the oligo-arginine chitosan and the sodium hyaluronate can effectively inhibit scalp oil from being discharged caused by excessive secretion of grease by the scalp when applied to the shampoo, so as to solve the trouble of poor appearance instrument caused by greasy hair of people.
The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention.

Claims (10)

1. The skin oil control composition is characterized by having a synergistic inhibition effect on 5 alpha-reductase in skin tissues so as to inhibit sebum secretion of sebaceous glands, and comprising the following components in parts by mass:
4-5 parts of saw palmetto extract;
3-4 parts of astragalus extract;
1-3 parts of coltsfoot leaf extract.
2. The skin oil control composition of claim 1, wherein the saw palmetto extract is a combination of a fat-soluble extract and an aqueous alcohol extract of saw palmetto; the astragalus extract is an alcohol-water extract; the coltsfoot leaf extract is an alcohol-water extract.
3. A hair oil control composition comprising the skin oil control composition according to claim 2, characterized by comprising the following components in parts by mass:
1-10 parts of skin oil control composition;
1-5 parts of auxiliary oil control auxiliary agent.
4. The hair oil control composition according to claim 3, wherein the auxiliary oil control auxiliary agent comprises the following components in parts by mass:
1-3 parts of oligo-arginine chitosan;
1-8 parts of a composition for hydrolyzing sodium hyaluronate.
5. The hair oil control composition of claim 4, wherein the hydrolyzed sodium hyaluronate has a molecular weight of 10KDa or less.
6. A shampoo comprising the hair management composition of claim 5, comprising the following components:
0.5 to 4.5 parts of hair oil control composition;
3.5 to 10.8 portions of matrix cleaner;
6.5 to 15.0 portions of amino acid surfactant;
3.5 to 5.8 portions of auxiliary surfactant;
0.3 to 1.0 part of thickener;
0.5 to 1.5 portions of scalp conditioner;
0.5 to 1.2 portions of pearling agent;
0.4 to 2.0 portions of other auxiliary agents;
a proper amount of pH regulator;
and proper amount of deionized water.
7. The shampoo of claim 6, wherein,
the matrix cleaning agent is at least one of fatty alcohol polyether sulfate, monoalkyl sulfate and fatty acyl methyl taurate;
the amino acid surfactant is sodium lauroyl glutamate;
the auxiliary surfactant is at least one of fatty acyl amphoacetate, fatty acyl propyl betaine and fatty amide hydroxypropyl sulfobetaine;
the thickener is at least one of carbomer, ammonium chloride, sodium chloride and sodium carboxymethyl cellulose;
the scalp conditioner is at least one of amino acids, allantoin, nicotinamide and keratin;
the pearling agent is at least one of glycol distearate and glycerol monostearate;
the other auxiliary agent is at least one of antistatic agent, preservative and essence.
8. The shampoo of claim 7 wherein the cleansing agent is a fatty alcohol polyether sulfate and the fatty alcohol polyether sulfate is sodium laureth sulfate.
9. The shampoo of claim 7 wherein the co-surfactant is a fatty acyl propyl betaine, which is lauroyl propyl betaine.
10. The shampoo of claim 7, wherein the shampoo is formulated,
the antistatic agent is at least one of polyquaternium and guar gum hydroxypropyl trimethyl ammonium chloride;
the preservative is at least one of phenoxyethanol, ethylhexyl glycerol, sodium benzoate, methylparaben and ethylparaben.
CN202311400512.2A 2023-10-26 2023-10-26 Skin oil control composition and application thereof Pending CN117357453A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118791560A (en) * 2024-06-17 2024-10-18 广州慕可生物科技有限公司 A peptide capable of regulating sebum secretion and its synthesis method and application

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118791560A (en) * 2024-06-17 2024-10-18 广州慕可生物科技有限公司 A peptide capable of regulating sebum secretion and its synthesis method and application

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