[go: up one dir, main page]

CN116421517B - Skin anti-aging composition and application and skin care product thereof - Google Patents

Skin anti-aging composition and application and skin care product thereof Download PDF

Info

Publication number
CN116421517B
CN116421517B CN202310385567.4A CN202310385567A CN116421517B CN 116421517 B CN116421517 B CN 116421517B CN 202310385567 A CN202310385567 A CN 202310385567A CN 116421517 B CN116421517 B CN 116421517B
Authority
CN
China
Prior art keywords
phase
skin
skin care
care product
aging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202310385567.4A
Other languages
Chinese (zh)
Other versions
CN116421517A (en
Inventor
邓学阳
叶飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hangzhou Weike Brand Management Co ltd
Original Assignee
Hangzhou Weike Brand Management Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hangzhou Weike Brand Management Co ltd filed Critical Hangzhou Weike Brand Management Co ltd
Priority to CN202310385567.4A priority Critical patent/CN116421517B/en
Publication of CN116421517A publication Critical patent/CN116421517A/en
Application granted granted Critical
Publication of CN116421517B publication Critical patent/CN116421517B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

A skin anti-aging composition and application and skin care products thereof belong to the technical field of skin care products. Consists of the following substances: 5 to 30 parts of bakuchiol, 20 to 60 parts of bidens pilosa extract and 25 to 75 parts of alfalfa extract. The skin anti-aging composition and the application and the skin care product thereof are that the skin care product prepared by the composition is milder than the vitamin A product which is smeared on the skin of a human body; the three active components are compounded, so that the synergistic effect is achieved, all important skin regulation and control functions of vitamin A can be well simulated, the activity of fibroblasts is enhanced, and the proliferation of the fibroblasts and the function of synthesizing skin beneficial components are obviously improved; the prepared skin care product can obviously reduce skin wrinkles, smooth skin and increase skin elasticity.

Description

Skin anti-aging composition and application and skin care product thereof
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a skin anti-aging composition and application thereof, and a skin care product.
Background
With the research development of skin care product science and the increasing demands of consumers on the efficacy of skin care products, anti-aging skin care becomes one of the most important consumer appeal. Research shows that the skin gradually enters a natural aging state from 20 to 25 years old, and the aging speed is different according to the genetic genes and living habits of each person. Due to the influence of factors such as fast-paced life, stay up, working pressure and the like, the primary and old appearance of skin of a part of young consumers aged 20 years is obvious, including dry and tight skin; facial relaxation sags slightly; fine lines appear on eyes; neck lines appear; slow recovery after tanning, etc. The anti-aging is to make various anti-aging works in the early stage of skin aging and delay the aging speed.
Human skin is composed of epidermis, basement membrane and dermis, and the actions of fibroblasts located in dermis include production of collagen, elastin, and dextran, etc., which have the actions of maintaining skin elasticity, dermis moisturizing, etc. The activity of fibroblasts plays a vital role in maintaining a healthy appearance of the skin. It has been observed that with age, the proliferation of fibroblasts and the function of synthesizing skin benefit ingredients gradually decrease.
Vitamin A is a very classical skin care ingredient which acts on the epidermis of the skin, promotes cell proliferation, maintains normal circulation of the skin, repairs lost collagen, reduces signs of wrinkles and premature aging (such as abnormal pigmentation, rough spots and dry skin), and has the effects of removing wrinkles and resisting photoaging. Vitamin a does not refer to a single chemical substance, but includes retinol (retinol, a alcohol), retinaldehyde (a aldehyde), retinoic acid (a acid), collectively referred to as Retinoids (Retinoids). However, there are different levels of irritation, whether acids, aldehydes, ketones, alcohols, or esters, and consumers experience discomforts such as molting, redness, stinging during use.
Thus, finding a safer, non-irritating ingredient to combat skin that has similar efficacy to vitamin a is an increasing concern for researchers in this field. As a result of the efforts of researchers in this field, many plant-derived, retinoid components have been discovered which are characterized as mild. They can in some ways even exceed the retinoids in terms of skin anti-aging ability, but none of the ingredients can mimic the effects of vitamin a in all directions.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to design and provide a skin anti-aging composition, application thereof and a technical scheme of skin care products, wherein three active components of the composition are compounded, have a synergistic effect, and can well simulate all important skin regulation and control functions of vitamin A; the prepared skin care product is mild, safe and non-irritating, and can remarkably reduce skin wrinkles, smooth skin and increase skin elasticity.
The anti-aging composition is characterized by comprising the following substances in parts by weight: 5 to 30 parts of bakuchiol, 20 to 60 parts of bidens pilosa extract and 25 to 75 parts of alfalfa extract.
The anti-aging composition is characterized by comprising 10-25 parts of bakuchiol, 30-50 parts of bidens pilosa extract and 30-65 parts of alfalfa extract.
The anti-aging composition is characterized by 16-20 parts of bakuchiol, 35-45 parts of bidens pilosa extract and 40-50 parts of alfalfa extract.
The application of the anti-aging composition in preparing skin care products.
The application of the anti-aging composition in preparing the skin care product is characterized in that the skin care product is water aqua, emulsion, cream, essence, facial mask or gel, and the addition amount of the composition is 0.5-10%, preferably 2-8%, more preferably 4-6% of the total mass of the skin care product.
The skin care product prepared from the anti-aging composition is characterized by comprising the composition and an auxiliary agent, wherein the auxiliary agent is at least one of a chelating agent, a thickening agent, a humectant, a solubilizer, an emulsifying agent, a pH regulator, a preservative, a solvent, a skin feel improver, grease and essence.
The skin care product prepared from the anti-aging composition is characterized in that:
the chelating agent is disodium EDTA and/or tetrasodium EDTA;
the thickener is at least one of carbomer, sodium polyacrylate, xanthan gum, acrylic acid (ester) copolymer sodium, acrylamide dimethyl taurate/VP copolymer, acrylic acid (ester) C10-30 alkanol acrylate cross-linked polymer, polyacrylate cross-linked polymer-6 and acrylic acid hydroxyethyl acrylate/sodium acryl dimethyl taurate copolymer;
the humectant is at least one of glycerol, propylene glycol, 1, 3-propylene glycol, butanediol, trehalose, dipropylene glycol, 1, 2-pentanediol, betaine and 1, 2-hexanediol;
the solubilizer is PEG-40 hydrogenated castor oil;
the emulsifier is at least one of cetostearyl oleate/sorbitan olive oleate, PEG-100 stearate, glyceryl stearate, lecithin, tween 60 and sodium stearyl glutamate;
the pH regulator is at least one of aminomethylpropanol, sodium hydroxide, arginine, citric acid, sodium citrate and tromethamine;
the preservative is at least one of phenoxyethanol, p-hydroxyacetophenone, potassium sorbate, sodium benzoate, octyl glycol and ethylhexyl glycerol;
the oil is at least one of squalane, BAIHUA oil, oleum Olivarum, caprylic/capric triglyceride, cetyl ethyl caproate, polydimethylsiloxane, and cetostearyl alcohol;
the skin feel improver is at least one of silica, corn starch and sodium starch octanoyl succinate;
the essence is daily essence;
the solvent is water.
The skin care product prepared from the anti-aging composition is characterized by being an anti-aging essence and comprising a phase A, a phase B and a phase C in percentage by weight;
phase A: 5% of glycerol, 0.8% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2% of dipropylene glycol, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol and the balance of water;
and B phase: 5% caprylic/capric triglyceride, 2% bakuchiol, 4% Bidens pilosa extract, 0.2% tween 60;
and C phase: 4% alfalfa extract;
the preparation method comprises the following steps: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, starting homogenizer, homogenizing at 5000-6000rpm for 4-6min; cooling to below 40deg.C, adding phase C, and stirring.
The skin care product prepared from the anti-aging composition is characterized by being anti-aging emulsion and comprising phase A, phase B and phase C in percentage by weight;
phase A: 5% of glycerol, 0.6% of polyacrylate crosslinked polymer-6, 5% of butanediol, 0.3% of sodium stearyl glutamate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol and the balance of water;
and B phase: 6% cetyl ethyl hexanoate, 0.45% bakuchiol, 2% dimethicone, 1.8% Bidens pilosa extract, 1% PEG-100 stearate & glyceryl stearate;
and C phase: 0.75% alfalfa extract;
the preparation method comprises the following steps: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, starting homogenizer, homogenizing at 5000-6000rpm for 5-10min; cooling to below 40deg.C, adding phase C, and stirring.
The skin care product prepared from the anti-aging composition is characterized by being anti-aging cream and comprising A phase, B phase and C phase in percentage by weight;
phase A: 5% of glycerol, 0.5% of sodium polyacrylate, 5% of butanediol, 2% of betaine, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol and the balance of water;
and B phase: 3% cetyl ethylhexanoate, 3% cetostearyl alcohol, 3% squalane, 0.6% bakuchiol, 2% polydimethylsiloxane, 0.4% bidens pilosa extract, 3% cetylstearyl olive oleate/sorbitan olive oleate;
and C phase: 1% alfalfa extract;
the preparation method comprises the following steps: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, starting homogenizer, homogenizing at 5000-6000rpm for 5-10min; cooling to below 40deg.C, adding phase C, and stirring.
The purity of the bakuchiol is more than or equal to 99 percent (tested by an HPLC method), and the bakuchiol can be directly purchased from the market.
The Bidens pilosa extract has the commodity name: revinage (Rawei internal treatment), manufacturer: brazil chemyupon (chemical alliance).
The alfalfa extract has the commodity name: VITANOL (vitamin), manufacturer: france Silab (alizarin blogs).
Alfalfa, the stems and leaves of which are rich in proteins, minerals, multivitamins and carotenes, and coumarin derivatives. The alfalfa extract is rich in galactomannans, like vitamin A, and can regulate metabolism of epidermis and increase synthesis of protein and silk polymerized protein serving as keratinocyte differentiation markers. Cell turnover is also improved in the absence of nutrients and calcium mediators, collagen I synthesis is stimulated, and extracellular matrix protection is achieved by inhibition of metalloproteinases that cause degradation of elastin.
The fructus Psoraleae has main chemical components of monoterpene phenol, monoterpene phenol dimer, heterodimer of monoterpene phenol and flavone, chalcone, coumarin and isoflavone, flavone, coumarin and fatty acid, etc. High purity bakuchiol extracted from fructus Psoraleae can promote proliferation of ESF-1 cells, promote expression of collagen and matrix metalloproteinase inhibitor mRNA, and inhibit expression of matrix metalloproteinase mRNA, thereby exerting skin aging resisting effect.
Bidens pilosa is whole herb of Bidens pilosa L. Is a Chinese medicine with the functions of detoxicating, detumescence, clearing heat, easing pain, promoting blood circulation, removing blood stasis, regulating qi and removing food retention. The invention adopts the Bidens pilosa extract from Brazil, is rich in long-chain unsaturated diterpenoid compounds with biological activity, can inhibit cell aging, and obviously improves skin texture and fine lines.
The skin anti-aging composition and the application and the skin care product thereof are that the skin care product prepared by the composition is milder than the vitamin A product which is smeared on the skin of a human body; the three active components are compounded, so that the synergistic effect is achieved, all important skin regulation and control functions of vitamin A can be well simulated, the activity of fibroblasts is enhanced, and the proliferation of the fibroblasts and the function of synthesizing skin beneficial components are obviously improved; the prepared skin care product can obviously reduce skin wrinkles, smooth skin and increase skin elasticity.
Detailed Description
The technical scheme of the present invention will be clearly and completely described in the following in connection with the embodiments of the present invention,
it will be apparent that the described embodiments are only some, but not all, embodiments of the invention.
The embodiments described below are exemplary and intended to be illustrative of the invention and should not be construed as limiting the invention
And are clearly limiting.
Example 1: an antiaging composition comprises bakuchiol 6 parts, herba Bidentis Bipinnatae extract 24 parts, and herba Medicaginis extract 70 parts.
Example 2: an antiaging composition comprises bakuchiol 5 parts, herba Bidentis Bipinnatae extract 20 parts, and herba Medicaginis extract 75 parts.
Example 3: an antiaging composition comprises bakuchiol 15 parts, herba Bidentis Bipinnatae extract 60 parts, and herba Medicaginis extract 25 parts.
Example 4: an antiaging composition comprises bakuchiol 20 parts, herba Bidentis Bipinnatae extract 40 parts, and herba Medicaginis extract 40 parts.
Example 5: an antiaging composition comprises bakuchiol 30 parts, herba Bidentis Bipinnatae extract 20 parts, and herba Medicaginis extract 50 parts.
The three components of bakuchiol, bidens pilosa extract and alfalfa extract have targets similar to the vitamin A on the skin, but can not be completely simulated. The alfalfa extract has high coincidence degree with vitamin A in the aspect of epidermal cell gene regulation, but does not influence the gene expression of vitamin A receptor (CRBP 1, CRBP 2), and bakuchiol has regulation and control effects on the two genes. In addition, bakuchiol provides similar activity to retinoids in terms of retinol binding and metabolic genes. However, alfalfa extract and bakuchiol have no regulatory effect on both the RARs and RXRs receptors. Whereas Bidens pilosa extract has a regulatory effect on both receptors. Table 1 shows important regulation targets of vitamin A on skin, and the regulation capacities of different components on different targets are shown in Table 1.
TABLE 1 Regulation ability of different Components on different targets
Target name Retinoids Alfalfa extract Bakuchiol Bidens pilosa extract
Papular urticaria antigen 1 (BPAG 1) - -
Cytokeratin 10 - -
Galectin-7 - -
Mitochondrial genome - -
Fatty aldehyde dehydrogenase (FALDH) - -
Thioredoxin (TRDX; TXN) - -
Thioredoxin peroxidase 2 (TDPX 2) - -
Superoxide dismutase 1 - -
S100 calbindin A4 - -
S100 calbindins A8, A9, A7 + +
Neutrophil activating peptide 78 (ENA 78) derived from epithelial cells + +
Granulocyte chemotactic protein 2 (GCP 2) + +
With heparinBound EGF growth factor (HB-EGF) + +
Platelet-derived growth factor A subunit (PDGFA) + +
Antichymotrypsin 1 (AACT; ACT) + +
Hyaluronate synthase 3 (HAS-3) + + +
Elastin + +
Interleukin 1 receptor type II (IL 1R 2) + + +
Cell retinol connexin I + Ο +
Tazarotene induction gene 1 (TIG 1) + +
Dehydrogenase/reductase SDR family member 9 precursor (DHRS 9) + +
Lecithin-retinol acylate transferase (LRAT) + +
Cytochrome P450 s + +
Collagen I + + + +
Collagen IV + + +
Integrin beta 4, beta 6 (Integrin beta 4, beta 6) + +
Laminin + +
Retinoic acid X receptors (Retinoid X receptors, RXRs) + Ο Ο +
Retinoic acid receptors (retinoic acid receptors, RARs) + Ο Ο -
Note that: "+" indicates positive regulation, "-" indicates negative regulation, and "O" indicates no regulation, and blank indicates no mention.
The results in table 1 show that: by comparing the regulation and control capability of bakuchiol, bidens pilosa extract and alfalfa extract on different targets, the combination and collocation of the three active ingredients can well simulate all important skin regulation and control functions of vitamin A (except RARs receptor). And the increased expression of RAR receptor is the main cause of redness, desquamation and fever of skin when using vitamin A products. Vitamin A can stimulate the increase of RAR receptor expression, and the combination and collocation of the three active ingredients can not stimulate the increase of RAR receptor expression, but can inhibit the expression to a certain extent, thereby reducing the occurrence of the phenomena of redness, desquamation and fever of skin. In addition, the bakuchiol has strong oxidation resistance, and the oxidation resistance of the other two components is improved by matching the bakuchiol, the bakuchiol and the bakuchiol together. In addition, the bakuchiol and the Bidens pilosa extract are both oily and sticky, and the alfalfa extract is a water-soluble extract, so that the use amount of the bakuchiol and the Bidens pilosa extract is correspondingly reduced by matching, and the sticky feel of the final product is reduced.
The anti-aging composition is applied to the preparation of skin care products, wherein the skin care products are water aqua, emulsion, cream, essence, facial mask or gel, and the addition amount of the composition is 0.5-10% of the total mass of the skin care products, preferably 2-8%, and more preferably 4-6%. The auxiliary agent is at least one of chelating agent, thickener, humectant, solubilizer, emulsifier, pH regulator, antiseptic, solvent, skin feel improver, oil and essence. The chelating agent is disodium EDTA and/or tetrasodium EDTA; the thickener is at least one of carbomer, sodium polyacrylate, xanthan gum, acrylic acid (ester) copolymer sodium, acrylamide dimethyl taurate/VP copolymer, acrylic acid (ester) C10-30 alkanol acrylate cross-linked polymer, polyacrylate cross-linked polymer-6 and acrylic acid hydroxyethyl acrylate/sodium acryl dimethyl taurate copolymer; the humectant is at least one of glycerol, propylene glycol, 1, 3-propylene glycol, butanediol, trehalose, dipropylene glycol, 1, 2-pentanediol, betaine and 1, 2-hexanediol; the solubilizer is PEG-40 hydrogenated castor oil; the emulsifier is at least one of cetostearyl oleate/sorbitan olive oleate, PEG-100 stearate, glyceryl stearate, lecithin, tween 60 and sodium stearyl glutamate; the pH regulator is at least one of aminomethylpropanol, sodium hydroxide, arginine, citric acid, sodium citrate and tromethamine; the preservative is at least one of phenoxyethanol, p-hydroxyacetophenone, potassium sorbate, sodium benzoate, octyl glycol and ethylhexyl glycerol; the oil is at least one of squalane, BAIHUA oil, oleum Olivarum, caprylic/capric triglyceride, cetyl ethyl caproate, polydimethylsiloxane, and cetostearyl alcohol; the skin feel improver is at least one of silica, corn starch and sodium starch octanoyl succinate; the essence is daily essence; the solvent is water.
Example 6: an anti-aging essence is added with 10% of example 4 and is prepared from the following components:
example 6 was prepared using the following procedure: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, starting homogenizer, homogenizing at 5000-6000rpm for 4-6min; cooling to below 40deg.C, adding phase C, and stirring.
In the above embodiment 6, the addition amount of the anti-aging composition is any content of 0.5-10% of the total mass of the skin care product, and the anti-aging composition may also include, but is not limited to, any mixture ratio of the embodiments 1-3 and 5, so as to achieve the skin care effect of the present invention.
Example 7: an anti-aging emulsion, added with 3% of example 3, is prepared from the following components:
example 7 was prepared using the following procedure: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, homogenizing at 5000-6000rpm for 5-10min; cooling to below 40deg.C, adding phase C, and stirring.
In the above embodiment 7, the addition amount of the anti-aging composition is any content of 0.5-10% of the total mass of the skin care product, and the anti-aging composition may also comprise, but is not limited to, any proportion of the embodiments 1-5, so as to achieve the skin care effect of the present invention.
Example 8: an anti-aging cream, added with 2% of example 5, is prepared from the following components:
example 8 was prepared using the following procedure: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, homogenizing at 5000-6000rpm for 5-10min; cooling to below 40deg.C, adding phase C, and stirring.
In the above embodiment 8, the addition amount of the anti-aging composition is any content of 0.5-10% of the total mass of the skin care product, and the anti-aging composition may also comprise, but is not limited to, any proportion of the embodiments 1-5, so as to achieve the skin care effect of the present invention.
The composition provided by the invention has the advantages of milder effect, good skin aging resistance and the like, which are further proved by corresponding experimental data.
Experiment 1: the compositions were tested for mildness by comparison, as shown in Table 2.
60 Chinese healthy female subjects were selected, with an age ranging from 20-30 years, with an average age of 26.3.+ -. 3.5 years. The random groups were divided into 2 groups, the first group using an emulsion containing 0.3% retinol, the second group using the emulsion of example 6, used at night daily for 3 consecutive days, and then the skin condition after use was evaluated.
Table 2 consumer evaluation after skin application
Symptoms appear Using retinol groups Use of example 6 group
Reddening and skinning 50% 0
Acne-breaking 40% 0
Fever and stinging pain 16.7% 0
No uncomfortable feeling is generated 0 100%
Note that: the appearance symptoms are multiple choice questions.
As can be seen from table 2: the essence prepared by the composition has no uncomfortable feeling in the use process. In contrast, the control group using 0.3% retinol showed all skin discomfort, different symptoms in different proportions, and some subjects even showed more than one skin problem. It follows that the skin care products containing the composition are much milder to the consumer than retinol.
Experiment 2: fibroblast activity promoting effect is shown in tables 3-4.
The combination of the three actives in the anti-aging compositions of the present invention resulted in comparative examples 1-6 and inventive example 4 for cell experiments.
TABLE 3 random combinations of actives for different samples
Sample numbering Bakuchiol (parts) Bidens pilosa extract (parts) Alfalfa extract (parts)
Example 4 20 40 40
Comparative example 1 20 - -
Comparative example 2 - 40 -
Comparative example 3 - - 40
Comparative example 4 20 40 -
Comparative example 5 20 - 40
Comparative example 6 - 40 40
Note that: "-" means that the ingredient was not added
Table 4I type collagen content determination table
Sample name Type I collagen synthesis was increased (%)
NT -
Positive control (100 ng/ml TGF-. Beta.1) 20.49
Example 4 38.91
Comparative example 1 17.91
Comparative example 2 18.23
Comparative example 3 15.11
Comparative example 4 20.32
Comparative example 5 23.26
Comparative example 6 21.83
As can be seen from Table 4, the amounts of bakuchiol, bidens pilosa extract, and alfalfa extract, respectively, increased by 17.91%, 18.23%, and 15.11% for type I collagen synthesis. And the corresponding increase of type I collagen synthesis is 20.32%, 23.26% and 21.83%. However, three components were present (example 4), and the increase in type I collagen synthesis was 38.91%. The same experiment was performed using examples 1 to 3 and example 5 of the present invention, wherein the increase in synthesis of type I collagen was 37.25% in example 1, 39.13% in example 2, 38.50% in example 3, and 39.67% in example 5. The experiment proves that the three active components are compounded and have synergistic effect.
Experiment 3: human efficacy evaluation tests are shown in tables 5-7.
30 female subjects were selected, aged 25 to 50 years, with an average age of 35.6.+ -. 7.5 years. The subjects used the emulsion of example 7 once a day, both early and late, and a 14 day and 28 day visit, at the same time during the day, during which the same other type of product had not been used. Before testing, the subject sits still in a constant temperature and humidity waiting area with the temperature of 21+/-1 ℃ and the relative humidity of 50+/-10% RH for 20 minutes; the inspector collects the values of the skin elasticity parameter R2, the skin firmness parameter F4, and the values of Sa, sq, and SV of the skin in the cheek region of the subject.
Note that: p value < 0.001. Rate of change = (post-use measurement-pre-use measurement)/pre-use measurement 100%. The higher the rate of change, the higher the skin elasticity increase.
Table 5 shows: the skin elasticity changes before and after 28 days of application of the product. The value of the cheek region skin elasticity parameter R2 was significantly increased by 29.36% 28 days after the application of the product, compared to before the application of the product. The composition can significantly improve skin elasticity.
Table 6 skin firmness parameters F4 descriptive statistics (Cutometer MPA 580) (n=30)
Note that: p value < 0.001. Rate of change = (post-use measurement-pre-use measurement)/pre-use measurement 100%. For the value of the firmness parameter F4, the lower the value, the better the skin firmness is indicated.
Table 6 shows: changes in skin firmness around 28 days after application of the product. The cheek region skin firmness parameter F4 was reduced by a few 42.32% significantly 28 days after product use compared to before product use. Indicating that the composition can significantly improve skin firmness.
Table 7 descriptive statistics of skin wrinkles conditions (PRIMOS PICO) (n=30)
Test index D0 (before using the product) D28 (use product for 28 days) Rate of change
Sa 26.3±4.6 20.5±4.3 -22.05%
Sq 34.3±7.8 28.7±6.5 -16.32%
SV -180.6±21.5 -168.6±19.8 6.64%
Note that: p value < 0.05.
As can be seen from table 7: after the subject used the emulsion containing the composition, the test showed that the Sa and Sq values decreased and the SV value increased over time. The composition is shown to be effective in improving skin wrinkling. According to the mechanism of wrinkle formation and the appearance of skin state, the skin elasticity, the compactness and the wrinkle condition can be combined with the anti-aging effect of the average product, and the combination of the test data shows that the skin care product containing the composition has obvious anti-aging effect.
The same human body efficacy evaluation test experiments are carried out by adopting the embodiment 6 and the embodiment 8 of the invention, and the skin care product disclosed by the embodiment 6 and the embodiment 8 can obviously improve the skin elasticity, the compactness and the obvious anti-aging effect.
The present invention is not limited to the above preferred embodiments, and any person skilled in the art, based on the technical solution of the present invention and the inventive concept thereof, can be replaced or changed within the scope of the present invention.

Claims (9)

1. An anti-aging composition is characterized by comprising the following components in parts by weight: 10 to 25 parts of bakuchiol, 30 to 50 parts of bidens pilosa extract and 30 to 65 parts of alfalfa extract.
2. An anti-aging composition according to claim 1, wherein the bakuchiol is 16-20 parts, the bidens pilosa extract is 35-45 parts, and the alfalfa extract is 40-50 parts.
3. Use of an anti-aging composition according to claim 1 in the preparation of a skin care product.
4. The use of an anti-aging composition according to claim 1 in the preparation of a skin care product, wherein the skin care product is a water agent, an emulsion, a cream, an essence, a facial mask or a gel, and the addition amount of the composition is 0.5-10% of the total mass of the skin care product.
5. The skin care product prepared from the anti-aging composition according to claim 1, which is characterized by comprising the anti-aging composition and an auxiliary agent, wherein the auxiliary agent is at least one of a chelating agent, a thickening agent, a humectant, a solubilizer, an emulsifier, a pH regulator, a preservative, a solvent, a skin feel improver, grease and essence.
6. The skin care product made of the anti-aging composition according to claim 5, wherein:
the chelating agent is disodium EDTA and/or tetrasodium EDTA;
the thickener is at least one of carbomer, sodium polyacrylate, xanthan gum, acrylic acid (ester) copolymer sodium, acrylamide dimethyl taurate/VP copolymer, acrylic acid (ester) C10-30 alkanol acrylate cross-linked polymer, polyacrylate cross-linked polymer-6 and acrylic acid hydroxyethyl acrylate/sodium acryl dimethyl taurate copolymer;
the humectant is at least one of glycerol, propylene glycol, butanediol, trehalose, dipropylene glycol, 1, 2-pentanediol, betaine and 1, 2-hexanediol;
the solubilizer is PEG-40 hydrogenated castor oil;
the emulsifier is at least one of cetostearyl oleate/sorbitan olive oleate, PEG-100 stearate, glyceryl stearate, lecithin, tween 60 and sodium stearyl glutamate;
the pH regulator is at least one of aminomethylpropanol, sodium hydroxide, arginine, citric acid, sodium citrate and tromethamine;
the preservative is at least one of phenoxyethanol, p-hydroxyacetophenone, potassium sorbate, sodium benzoate, octyl glycol and ethylhexyl glycerol;
the oil is at least one of squalane, BAIHUA oil, oleum Olivarum, caprylic/capric triglyceride, cetyl ethyl caproate, polydimethylsiloxane, and cetostearyl alcohol;
the skin feel improver is at least one of silica, corn starch and sodium starch octanoyl succinate;
the essence is daily essence;
the solvent is water.
7. The skin care product prepared from the anti-aging composition according to claim 5, wherein the skin care product is an anti-aging essence, and comprises phase A, phase B and phase C in percentage by weight;
phase A: 5% of glycerol, 0.8% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2% of dipropylene glycol, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol and the balance of water;
and B phase: 5% caprylic/capric triglyceride, 2% bakuchiol, 4% Bidens pilosa extract, 0.2% tween 60;
and C phase: 4% alfalfa extract;
the preparation method comprises the following steps: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, starting homogenizer, homogenizing at 5000-6000rpm for 4-6min; cooling to below 40deg.C, adding phase C, and stirring.
8. The skin care product prepared from the anti-aging composition according to claim 5, wherein the skin care product is an anti-aging emulsion and comprises the phase A, the phase B and the phase C in percentage by weight;
phase A: 5% of glycerol, 0.6% of polyacrylate crosslinked polymer-6, 5% of butanediol, 0.3% of sodium stearyl glutamate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol and the balance of water;
and B phase: 6% cetyl ethyl hexanoate, 0.45% bakuchiol, 2% dimethicone, 1.8% Bidens pilosa extract, 1% PEG-100 stearate & glyceryl stearate;
and C phase: 0.75% alfalfa extract;
the preparation method comprises the following steps: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, starting homogenizer, homogenizing at 5000-6000rpm for 5-10min; cooling to below 40deg.C, adding phase C, and stirring.
9. The skin care product prepared from the anti-aging composition according to claim 5, wherein the skin care product is an anti-aging cream and comprises the phase A, the phase B and the phase C in percentage by weight;
phase A: 5% of glycerol, 0.5% of sodium polyacrylate, 5% of butanediol, 2% of betaine, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol and the balance of water;
and B phase: 3% cetyl ethylhexanoate, 3% cetostearyl alcohol, 3% squalane, 0.6% bakuchiol, 2% dimethicone, 0.4% bidens pilosa extract, 3% cetostearyl oleate/sorbitan olive oleate;
and C phase: 1% alfalfa extract;
the preparation method comprises the following steps: heating the phase A to 60-65 ℃, and stirring to be uniform; heating the phase B to 60-65 ℃, and stirring until the phase B is completely melted; adding phase B into phase A, starting homogenizer, homogenizing at 5000-6000rpm for 5-10min; cooling to below 40deg.C, adding phase C, and stirring.
CN202310385567.4A 2023-04-12 2023-04-12 Skin anti-aging composition and application and skin care product thereof Active CN116421517B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310385567.4A CN116421517B (en) 2023-04-12 2023-04-12 Skin anti-aging composition and application and skin care product thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310385567.4A CN116421517B (en) 2023-04-12 2023-04-12 Skin anti-aging composition and application and skin care product thereof

Publications (2)

Publication Number Publication Date
CN116421517A CN116421517A (en) 2023-07-14
CN116421517B true CN116421517B (en) 2024-03-01

Family

ID=87090267

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202310385567.4A Active CN116421517B (en) 2023-04-12 2023-04-12 Skin anti-aging composition and application and skin care product thereof

Country Status (1)

Country Link
CN (1) CN116421517B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117205103A (en) * 2023-10-07 2023-12-12 诺德溯源(广州)生物科技有限公司 A firming and anti-aging composition containing plant A alcohol suitable for sensitive skin and its application
CN118593400B (en) * 2024-06-18 2025-03-04 广东丹兰国际生物科技有限公司 Anti-wrinkle anti-aging composition containing traditional Chinese medicine components, and preparation method and application thereof
CN119280095B (en) * 2024-12-10 2025-03-21 广州源大生物科技有限公司 Anti-wrinkle composition, use, skin care product, anti-wrinkle essence cream

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015167552A1 (en) * 2014-04-30 2015-11-05 Kimberly-Clark Worldwide, Inc. Topical compositions including a bidens extract for reducing signs of skin aging
CN105377230A (en) * 2013-07-16 2016-03-02 宝洁公司 Method of improving the appearance of aging skin
CN107496316A (en) * 2016-06-13 2017-12-22 欧诗漫生物股份有限公司 A kind of face cream and preparation method thereof
FR3067593A1 (en) * 2017-06-20 2018-12-21 Jean-Noel Thorel USE OF PLANT EXTRACTS FOR THE DERMATOCOSMAL TREATMENT OF INFLAMMATORY CONDITIONS RELATED TO OVERPRODUCTION OF IL-17
CN112569130A (en) * 2019-09-30 2021-03-30 珀莱雅化妆品股份有限公司 Plant extract with pore tightening effect and preparation method thereof
CN112618396A (en) * 2021-01-04 2021-04-09 成都健腾生物技术有限公司 A cosmetic prepared from bakuchiol
CN113274331A (en) * 2021-06-22 2021-08-20 科丝美诗(中国)化妆品有限公司 Acne-removing and anti-inflammatory composition and preparation method and application thereof
KR102370225B1 (en) * 2021-10-15 2022-03-04 주식회사 엔에스엘 Cream type cosmetic composition containing bakuchiol and preparing method thereof
CN114478196A (en) * 2021-01-27 2022-05-13 江苏巴帝恩生物科技有限公司 Method for extracting and purifying bakuchiol from radix Ulmi Pumilae and its application in cosmetics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9636292B2 (en) * 2015-07-30 2017-05-02 Truth Aesthetics LLC Topical skin care composition for night use

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105377230A (en) * 2013-07-16 2016-03-02 宝洁公司 Method of improving the appearance of aging skin
WO2015167552A1 (en) * 2014-04-30 2015-11-05 Kimberly-Clark Worldwide, Inc. Topical compositions including a bidens extract for reducing signs of skin aging
CN107496316A (en) * 2016-06-13 2017-12-22 欧诗漫生物股份有限公司 A kind of face cream and preparation method thereof
FR3067593A1 (en) * 2017-06-20 2018-12-21 Jean-Noel Thorel USE OF PLANT EXTRACTS FOR THE DERMATOCOSMAL TREATMENT OF INFLAMMATORY CONDITIONS RELATED TO OVERPRODUCTION OF IL-17
CN112569130A (en) * 2019-09-30 2021-03-30 珀莱雅化妆品股份有限公司 Plant extract with pore tightening effect and preparation method thereof
CN112618396A (en) * 2021-01-04 2021-04-09 成都健腾生物技术有限公司 A cosmetic prepared from bakuchiol
CN114478196A (en) * 2021-01-27 2022-05-13 江苏巴帝恩生物科技有限公司 Method for extracting and purifying bakuchiol from radix Ulmi Pumilae and its application in cosmetics
CN113274331A (en) * 2021-06-22 2021-08-20 科丝美诗(中国)化妆品有限公司 Acne-removing and anti-inflammatory composition and preparation method and application thereof
KR102370225B1 (en) * 2021-10-15 2022-03-04 주식회사 엔에스엘 Cream type cosmetic composition containing bakuchiol and preparing method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"The Influence of Oligosaccharides on Skin Aging: An Alternative to Retinoids";Maud Jouandeaud等;《Cosmetics & Toiletries》;第119卷(第6期);第67-73页 *
刘国良 等."补骨脂酚对光老化HSF细胞保护作用研究".《中国医药导报》.2019,第16卷(第19期),第11-15和24页. *
孙成贤 等."三叶鬼针草乙醇提取物抗菌抗氧化活性研究".《安徽农学通报》.2021,第27卷(第11期),第32-35页. *

Also Published As

Publication number Publication date
CN116421517A (en) 2023-07-14

Similar Documents

Publication Publication Date Title
CN116421517B (en) Skin anti-aging composition and application and skin care product thereof
CN111249209B (en) Moisturizing repair cream and preparation method thereof
AU707028B2 (en) Use,in a composition, of an extract of at least one labiate
CN104887589B (en) A kind of skin nursing skin cream and preparation method thereof
CN111450010A (en) Composition with anti-aging effect and application thereof in cosmetics
CN110339149A (en) A kind of facial treatment essence cream of the anti-ageing low sensitization of the whitening of the product containing lactobacillus fermentation
CN110302091B (en) Composition containing nicotinamide adenine dinucleotide for resisting skin aging and preparation method and application thereof
CN111956591A (en) Anti-allergy, soothing and skin color improving cosmetic composition and preparation method thereof
CN114712275A (en) Anti-wrinkle repair composition and preparation method thereof, and cosmetic and preparation method thereof
CN112006958A (en) Depilatory cream and preparation method thereof
CN112641692A (en) Anti-allergy repairing composition and preparation method and application thereof
KR101130245B1 (en) Composition formed by using mixture of herbal extracts and Muskrat Ondatra zibethicusmusk for Anti-aging
WO2024217163A1 (en) Tricholoma matsutake extract-containing composition with anti-aging effect, and use thereof
CN114099388B (en) Anti-wrinkle composition and preparation method and application thereof
KR101817514B1 (en) New use of hesperetin
CN110693778A (en) Face cream and production process thereof
CN104188859B (en) A kind of crease-resistant skin care emulsion containing natural component extract and preparation method thereof
JP4906179B2 (en) Topical skin preparation
CN117205103A (en) A firming and anti-aging composition containing plant A alcohol suitable for sensitive skin and its application
KR20210090870A (en) Cosmetic composition with excellent skin barrier using skin microbiome
CN117017850A (en) External cosmetic composition for removing acne and repairing acne and application thereof
CN116407486A (en) Active composition, cosmetic composition, application of active composition, repairing essence and preparation method of repairing essence
US11123386B2 (en) Fermentation product of Punica granatum and uses thereof
CN109431881B (en) Tibetan sheep oil for preventing skin from being cracked due to dryness
CN118340696B (en) Mild anti-aging composition suitable for sensitive muscles and preparation method and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant