CN112006958A - Depilatory cream and preparation method thereof - Google Patents

Abstract

The invention relates to depilatory cream and a preparation method thereof, and the depilatory cream comprises the following raw material components: 63-70 parts of water, 3-5 parts of humectant, 6-7 parts of emollient, 0.1-0.2 part of water-soluble thickener, 1-4 parts of oil-soluble thickener, 2-4 parts of emulsion stabilizer, 7-9 parts of emulsifier, 2-3.5 parts of pH regulator, 0.2-1 part of bisabolol, 0.1-0.3 part of allantoin, 0.2-0.5 part of skin conditioner and 4-6 parts of chemical depilatory, wherein the skin conditioner is a mixture of butanediol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra root extract, chamomile flower extract and rosemary leaf extract. The depilatory cream disclosed by the invention has excellent depilatory effect and use comfort, is wide in applicable population and is suitable for large-scale production and application.

Description

Depilatory cream and preparation method thereof

Technical Field

The invention belongs to the technical field of daily chemicals, and particularly relates to depilatory cream and a preparation method thereof.

Background

The depilatory cream utilizes chemical substances in the depilatory cream to dissolve the hair structure so as to achieve the purpose of depilation. The main component of the preparation is thioglycolic acid (calcium), which has certain irritation and is suitable for people who are afraid of pain but have low possibility of skin allergy.

CN110812257A discloses a depilatory cream and a preparation method thereof. The depilatory cream comprises a mixture A, a mixture B, a mixture C and a component D, wherein: the mixture A comprises the following components in parts by weight: 4-6 parts of cetearyl alcohol; 2-4 parts of mineral oil; 2-5 parts of ethylhexyl palmitate; 93-5 parts of ceteareth-93; 2-5 parts of glycerol stearate; 0.1-0.5 part of butylated hydroxytoluene; the mixture B comprises the following components in parts by weight: 60-70 parts of water; 3-7 parts of glycerol; 2-5 parts of potassium hydroxide; 0.5-1 part of betaine; 0.1-0.5 part of hydroxyethyl cellulose; 0.1-0.3 part of methylparaben; 0.1-0.3 part of propyl hydroxybenzoate; the mixture C comprises 6-10 parts of calcium thioglycolate; 5-7 parts of nano activated carbon; the component D is 0.3-0.5 part of essence. The depilatory cream utilizes the nano activated carbon to play a role in absorbing the taste of calcium thioglycolate, has certain effect on preparing safe and odorless depilatory cream, but has poor expectation on the aspect of relaxing stimulation in terms of raw material selection of the depilatory cream.

CN110393673A discloses a small negative oxygen ion group health-care depilatory cream which is composed of the following raw materials: 90-97 parts of commercial depilatory cream, 0.1-5 parts of natural mineral nano material, 0.1-2 parts of auxiliary agent. The natural mineral nano materials in the depilatory cream specifically comprise what, and the mechanism of releasing small negative oxygen ion groups to generate substances and rays beneficial to human bodies and the function of preventing allergy and relieving irritation of the generated small negative oxygen ion groups are difficult to judge.

In addition, because a better depilatory effect may require more chemical depilatory agents to be added, and more chemical depilatory agents bring more obvious skin discomfort, the existing depilatory cream generally has the problem that the depilatory effect and the use comfort are difficult to meet the requirements at the same time, and the prior art needs to provide a depilatory product with good depilatory effect and high use comfort.

Disclosure of Invention

The invention aims to provide a depilatory cream which has excellent depilatory effect, is not easy to cause allergy and has high use comfort and a preparation method thereof, so as to solve the problems in the prior art.

The technical scheme of the invention is as follows:

a depilatory cream is characterized by comprising the following raw material components: 63-70 parts of water, 3-5 parts of humectant, 6-7 parts of emollient, 0.1-0.2 part of water-soluble thickener, 1-4 parts of oil-soluble thickener, 2-4 parts of emulsion stabilizer, 7-9 parts of emulsifier, 2-3.5 parts of pH regulator, 0.2-1 part of bisabolol, 0.1-0.3 part of allantoin, 0.2-0.5 part of skin conditioner and 4-6 parts of chemical depilatory, wherein the skin conditioner is a mixture of butanediol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra root extract, chamomile flower extract and rosemary leaf extract.

Preferably, the depilatory cream comprises the following raw material components: 66.3 parts of water, 4 parts of humectant, 7 parts of emollient, 0.15 part of water-soluble thickener, 3 parts of oil-soluble thickener, 3 parts of emulsion stabilizer, 7 parts of emulsifier, 2.8 parts of pH regulator, 0.5 part of bisabolol, 0.2 part of allantoin, 0.3 part of skin conditioner and 5 parts of chemical depilatory.

In the depilatory cream, the bisabolol is extracted from chrysanthemum plants, has the functions of resisting inflammation and inhibiting bacteria, has good compatibility with skin, can reduce skin inflammation, relieve skin acne, prevent acne, improve the anti-irritation capability of the skin and repair the skin with inflammation injury. Allantoin can promote cell growth and metabolism, soften stratum corneum protein, promote wound healing, treat skin injury or infection, and moisten skin, repair and moisturize skin. The depilatory cream is also added with a skin conditioner consisting of 7 plant extracts, is compounded with bisabolol and allantoin, plays a better role in anti-allergy, soothing and repairing, and resists skin inflammation together, so that the comfort in use of the depilatory cream is greatly improved.

Specifically, the skin conditioner is a mixture of butanediol, water, a centella asiatica extract, a polygonum cuspidatum root extract, a scutellaria baicalensis root extract, a tea leaf extract, a glycyrrhiza glabra root extract, a chamomile flower extract and a rosemary leaf extract in a weight ratio of 50:38:5:2:2:1:1:0.5: 0.5. In the skin conditioner, 1, terpenoid compounds in the centella asiatica extract can obviously improve the content of collagen and cell layer fibronectin (fibronectin is widely involved in the processes of cell migration, adhesion, proliferation, hemostasis, skin tissue repair and the like), can stimulate the production of I type collagen for promoting scar maturation, and can reduce the generation of inflammatory reaction. In addition, the centella asiatica extract can reduce the production of proinflammatory mediators (IL-1, MMP-1), and improve and repair the barrier function of the skin. And can significantly increase the hydration level of the stratum corneum, which is mainly associated with triterpenoid saponins in centella asiatica extracts, which are hydrophilic sugar chains, mainly glucose and rhamnose, that bind water in the occlusive layer, improve the epidermal barrier capacity, and enhance skin moisture. 2. The main functional components of the giant knotweed root extract are resveratrol and emodin. Studies have shown that resveratrol and emodin exhibit a wide range of antioxidant properties, such as LDL cholesterol oxidation and lipid peroxidation. 3. The scutellaria root extract can clear heat, dry dampness, purge fire, remove toxicity, stop bleeding and prevent abortion. Modern pharmacological studies show that the scutellaria baicalensis root extract can obviously inhibit rat paw swelling caused by carrageenin, reduce PGE2 and MDA content in local inflammation tissues of rat paw, and reduce NO content in rat paw tissues, and the scutellaria baicalensis root extract is prompted to have obvious anti-inflammatory effect, and the anti-inflammatory mechanism of the scutellaria baicalensis root extract is probably related to reduction of generation of PGE2 in the inflammation tissues, inhibition of lipid peroxide formation in tissue inflammation and reduction of NO activity. 4. The main active components of the tea extract comprise tea polyphenol, caffeine, aromatic oil, water, minerals, pigments, carbohydrates, proteins, amino acids, vitamins and the like. The research shows that: the active substances such as tea polyphenol and the like have the effects of detoxification and radiation resistance, are novel natural antioxidants, have strong antioxidant effect at normal temperature and low concentration, have the inhibiting effect on collagenase and elastase, can prevent the content reduction or denaturation of elastin, maintain the skin elasticity and achieve the anti-wrinkle effect. In addition, the tea polyphenols have effects of sterilizing, resisting skin aging, and reducing skin injury caused by ultraviolet radiation in sunlight. 5. The glycyrrhiza glabra root extract can penetrate into the skin, keeps high activity, effectively inhibits the activity of various enzymes (such as tyrosinase) in the melanin generation process, is a quick, efficient, safe and green sun-screening, whitening and freckle-removing cosmetic additive, and simultaneously has the effects of preventing rough skin, resisting inflammation and resisting bacteria. 6. The chamomile flower extract can dispel wind, clear heat, calm liver and improve vision. Can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, and blurred vision. Can be used in cosmetics for balancing oil secretion, inhibiting fat, resisting acne, eliminating black speck, and whitening skin. 7. Rosemary leaf extract contains rosmanol, carnosol and carnosic acid as main ingredients. The main components in the rosemary extract have strong antioxidant activity.

The skin conditioner has a good anti-inflammatory effect through the combination of 7 plant components, and in vitro experiments show that the skin conditioner has anti-inflammatory and immunoregulation effects by reducing the generation of inflammatory factors IL-8 and INF-alpha and simultaneously inhibiting the activity of an immunoregulatory factor NF-kB, thereby effectively resisting the skin irritation induced by various reasons.

In order to further improve the comfort of the depilatory cream, the depilatory cream also comprises a humectant, an emollient and other raw materials, wherein the humectant and the emollient can be raw materials conventionally used in the field, for example, the humectant can be any one or more of glycerin, butanediol, propylene glycol, urea and sodium hyaluronate, and preferably urea; the emollient can be one or more of mineral oil, ethylhexyl palmitate, isopropyl myristate, caprylic/capric triglyceride, shea butter, sea buckthorn seed oil, and tocopherol acetate, preferably mixture of mineral oil and ethylhexyl palmitate at weight ratio of 2-5: 1-5. The preferred humectant and emollient raw materials can ensure that the depilatory cream has better effects of moistening and protecting skin, and further reduce the skin irritation of the chemical depilatory.

The water-soluble thickening agent adopted by the depilatory cream can be any one of xanthan gum, carbomer, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and ethyl cellulose; the oil soluble thickener can be cetearyl alcohol, glyceryl stearate, or beeswax. The emulsion stabilizer is preferably a mixture of sodium magnesium fluorosilicate and magnesium trisilicate in a weight ratio of 4:6, and the emulsifier is preferably a mixture of PEG-100 stearate/glyceryl stearate, steareth-20 and steareth-21 in a weight ratio of 2-4:1-4: 1-4. The chemical depilatory is preferably calcium thioglycolate which is used as a reducing agent to destroy disulfide bonds in hair protein so as to achieve the aim of lightening or dissolving hair, thereby achieving the depilatory effect. 0.45-0.75 weight part of preservative and 0.02-0.1 weight part of aromatic can be further included for respectively improving the preservation performance of the depilatory cream and lightening the taste of calcium thioglycolate, so that the depilatory cream has good olfactory experience in the using process.

The preparation method of the depilatory cream comprises the following steps:

(1) mixing water, humectant, water soluble thickener, emulsion stabilizer, pH regulator, allantoin, and chemical depilatory, heating to 80-85 deg.C, and keeping the temperature to obtain phase A;

(2) mixing emollient, oil soluble thickener, emulsifier, and bisabolol, heating to 80-85 deg.C, and keeping the temperature to obtain phase B;

(3) mixing the phase A and the phase B, and homogenizing to obtain a cream matrix;

(4) cooling cream matrix, adding skin conditioner, and stirring to obtain depilatory cream.

The invention has the beneficial effects that:

the depilatory cream provided by the invention is added with the components including bisabolol, allantoin and a skin conditioner consisting of 7 plant extract components, so that the finally formed depilatory cream has an excellent depilatory effect, greatly improves the skin discomfort caused by a chemical depilatory commonly existing in the existing depilatory products, does not cause skin stabbing pain, burning, redness and itching and the like in use, does not cause inflammation of hair follicles, and is more suitable for more people. In addition, the raw materials are easy to obtain, and the preparation method is simple and suitable for large-scale production and application.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

In the following examples, the skin conditioner is a mixture of butylene glycol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea leaf extract, glycyrrhiza glabra root extract, matricaria chamomilla extract, and rosemary leaf extract, purchased from Biospectrum, where butylene glycol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea leaf extract, glycyrrhiza glabra root extract, matricaria chamomilla flower extract, and rosemary leaf extract are in a weight ratio of 50:38:5:2: 1:1:0.5: 0.5.

TABLE 1 depilatory cream formulation

The preparation method comprises the following steps:

(1) adding the phase A raw material into a water phase pot, stirring and heating to 80 ℃, fully mixing, and keeping the temperature for later use;

(2) adding the phase B raw material into an oil phase pot, stirring and heating to 80 ℃, fully mixing, and keeping the temperature for later use;

(3) firstly, pumping the phase A raw material into a vacuum emulsifying pot, pumping the phase B raw material into the vacuum emulsifying pot, uniformly stirring, homogenizing and emulsifying for 3-5 minutes, continuously stirring, vacuumizing, and keeping the temperature for 10 minutes;

(4) cooling to 46 deg.C, adding C phase raw materials, and stirring thoroughly;

skin irritation test

20 healthy adult mice were divided into 4 groups of 5 mice eachAfter marking 2X 2cm areas on both sides of the spinal column of the mouse and performing depilation treatment, the left side is a test area and the right side is a blank control, each group of mice was evenly coated with the depilatory cream of example 3 of the present invention, comparative document 1, comparative example 2 and a commercially available depilatory cream (0.5 g/cm) in the test area, respectively²) And then covering with gauze, keeping for 2h, wiping with a paper towel, cleaning with clear water, wiping to dry, and observing the degree of skin injury. And (3) excellent: the skin surface of the test area has no obvious difference compared with the blank control area; good: the skin surface of the test area is reddened to a certain extent compared with the blank control area; difference: the skin surface of the test area was somewhat damaged or even bleeding compared to the blank control area.

The results show that the skin damage levels of 5 mice using the depilatory cream of example 1 of the present invention were excellent; the skin damage levels of 5 mice using the depilatory cream of comparative example 1 were all good; of the mice using the depilatory cream of comparative example 2, 3 mice had good skin damage and 2 mice had excellent skin damage; of the mice using the commercial depilatory cream, 2 were good, and the other 3 were poor. The results show that the skin irritation of the invention is extremely low, and the invention has obvious advantages compared with the commercial products. The low skin irritation of the present invention is related to 3 kinds of raw materials including a skin conditioner, allantoin, and bisabolol, and when one or two of the 3 kinds of raw materials are removed, it is difficult to achieve a comparable low skin irritation effect even if the contents of the other raw materials are increased.

Test of overall use effect

60 female volunteers who have depilation requirements and are sensitive to the skin are randomly selected to evaluate the using effect of the depilatory cream prepared by the method, all the volunteers are randomly divided into 6 groups of 10, and the groups are respectively given to examples 1-3, comparative examples 1-2 and commercially available depilatory creams for use, and the using method is as follows: applying appropriate amount of the medicinal liquid to the armpit along the direction opposite to the direction of the hairs, keeping the medicinal liquid in contact with the armpit for about five minutes, and wiping off the medicinal liquid with facial tissue. After finishing using, all volunteers score each sample unhairing effect and use travelling comfort, and the unhairing effect is mainly considered from the aspect of the hair removal rate, and the standard of grading refers to: hair removal > 99% (i.e. no significant residual hair visible to the naked eye): 40-50 minutes; the hair removal rate is between 90% and 99%: 20-40 points (i.e., a small amount of hair remaining less than 0.5mm is visible to the naked eye); hair removal was less than 90% (i.e. more than 0.5mm of remaining hair was visible to the naked eye): 0-20 minutes. The use comfort is mainly considered from the aspect of skin irritation in use, and the scoring standard refers to the following conditions: no obvious discomfort feeling is 40-50 minutes; slight discomfort which can be tolerated by stabbing pain, burning and the like is 20-40 minutes; 0-20 points of obvious uncomfortable feelings such as stabbing pain, burning and the like which are relatively endured. When the scores of the samples are counted, the highest score and the lowest score are removed firstly, then the average value is taken, and the evaluation result of the using effect of each sample is shown in table 2.

TABLE 2 evaluation of depilatory cream usage

Group of	Depilatory effect (50 minutes)	Comfort of use (50 minutes)	General score (100 points)
				EXAMPLE 1 group	45.4	46.6	92
EXAMPLE 2 group	47.5	45.4	92.9
				EXAMPLE 3 group	46.9	47.2	94.1
Comparative example 1 group	46.2	38.7	84.9
				Comparative example 2 group	47.1	40.3	87.4
Commercial sample set	40.5	31.9	72.4

The results show that the depilatory cream has excellent depilatory effect, can thoroughly remove hair, has high use comfort, generally does not stimulate the skin in use, and can be suitable for people with sensitive skin, and the commercial depilatory cream can basically meet the requirements on depilatory effect, but easily causes skin stimulation in use, so that the depilatory cream is not suitable for people with sensitive skin.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims (10)

1. A depilatory cream is characterized by comprising the following raw material components: 63-70 parts of water, 3-5 parts of humectant, 6-7 parts of emollient, 0.1-0.2 part of water-soluble thickener, 1-4 parts of oil-soluble thickener, 2-4 parts of emulsion stabilizer, 7-9 parts of emulsifier, 2-3.5 parts of pH regulator, 0.2-1 part of bisabolol, 0.1-0.3 part of allantoin, 0.2-0.5 part of skin conditioner and 4-6 parts of chemical depilatory, wherein the skin conditioner is a mixture of butanediol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra root extract, chamomile flower extract and rosemary leaf extract.

2. A depilatory cream as claimed in claim 1, characterised in that the raw material components comprise: 66.3 parts of water, 4 parts of humectant, 7 parts of emollient, 0.15 part of water-soluble thickener, 3 parts of oil-soluble thickener, 3 parts of emulsion stabilizer, 7 parts of emulsifier, 2.8 parts of pH regulator, 0.5 part of bisabolol, 0.2 part of allantoin, 0.3 part of skin conditioner and 5 parts of chemical depilatory.

3. The depilatory cream of claim 1, wherein the skin conditioning agent is a mixture of butylene glycol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea leaf extract, glycyrrhiza glabra root extract, chamomile flower extract, and rosemary leaf extract in a weight ratio of 50:38:5:2:2:1:1:0.5: 0.5.

4. A depilatory cream as claimed in claim 1, wherein the moisturizer is any one or more of glycerol, butylene glycol, propylene glycol, urea, sodium hyaluronate; the emollient is one or more of mineral oil, ethylhexyl palmitate, isopropyl myristate, caprylic/capric triglyceride, shea butter, sea buckthorn seed oil, and tocopherol acetate.

5. A depilatory cream according to claim 4 characterised in that the humectant is urea and the emollient is a mixture of mineral oil and ethylhexyl palmitate in a weight ratio of 2-5: 1-5.

6. A depilatory cream according to claim 1, characterised in that the water-soluble thickener is any of xanthan gum, carbomer, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, ethyl cellulose; the oil-soluble thickening agent is any one of cetearyl alcohol, glyceryl stearate and beeswax.

7. A depilatory cream as claimed in claim 1, characterised in that the emulsion stabiliser is a mixture of sodium magnesium fluorosilicate and magnesium trisilicate in a weight ratio of 4:6 and the emulsifier is a mixture of PEG-100 stearate/glyceryl stearate, steareth-20 and steareth-21 in a weight ratio of 2-4:1-4: 1-4.

8. A depilatory cream according to claim 1, characterised in that the chemical depilatory agent is calcium thioglycolate.

9. A depilatory cream as claimed in claim 1, characterised in that the raw material components also comprise 0.45 to 0.75 parts by weight of preservative and 0.02 to 0.1 parts by weight of fragrance.

10. A process for preparing a depilatory cream according to claims 1 to 8, comprising the steps of:

(1) mixing water, humectant, water soluble thickener, emulsion stabilizer, pH regulator, allantoin, and chemical depilatory, heating to 80-85 deg.C, and keeping the temperature to obtain phase A;

(2) mixing emollient, oil soluble thickener, emulsifier, and bisabolol, heating to 80-85 deg.C, and keeping the temperature to obtain phase B;

(3) mixing the phase A and the phase B, and homogenizing to obtain a cream matrix;

(4) cooling cream matrix, adding skin conditioner, and stirring to obtain depilatory cream.