CN116173176A - A kind of anti-fatigue traditional Chinese medicine composition and preparation method thereof - Google Patents

Abstract

The invention discloses an anti-fatigue traditional Chinese medicine composition and a preparation method thereof. It contains the following traditional Chinese medicine raw materials in the following weight ratios: 8-12 parts of soybean peptide powder, 9-15 parts of sealwort, 3-9 parts of ginseng, and 6-6 parts of lily 12 parts, Astragalus 9‑30 parts, Lycium barbarum 6‑12 parts, Rehmannia glutinosa 10‑15 parts, Jujube 6‑15 parts, Suanzaoren 5‑10 parts, lotus seeds 6‑15 parts, yam 11‑13 parts, licorice 6‑ 8 parts, and disclosed its preparation method, after extracting the medicinal materials, adding soybean peptide powder, and preparing an oral liquid, the medicine of the present invention has the effects of replenishing energy, replenishing qi and strengthening the body, calming the mind and calming the nerves, and has a good effect of recovering from fatigue. The traditional Chinese medicine composition of the present invention is an oral liquid made from the above-mentioned traditional Chinese medicine raw materials or pharmaceutically acceptable auxiliary materials.

Description

A kind of anti-fatigue traditional Chinese medicine composition and preparation method thereof

technical field

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an anti-fatigue traditional Chinese medicine composition and a preparation method thereof.

Background technique

From the perspective of modern medicine, fatigue is a sub-health state. With the accelerated pace of modern life, most people are always in the process of high-intensity physical and mental work, which makes this state universal. If things go on like this, it will not only affect life The quality is affected, and it will also aggravate the occurrence of various physiological diseases. Fatigue can be roughly divided into three categories: exercise fatigue, pathological fatigue, and mental fatigue. Exercise-induced fatigue is the most common, which is a temporary decline of the body caused by the incoordination of exercise ability and physiological functions caused by exercise. Usually this kind of fatigue does not make people have a particularly strong sense of discomfort, but its duration is often positively correlated with exercise time; pathological fatigue is usually a variety of diseases such as some consumptive and chronic diseases, because of its slow therapeutic effect Make the body feel tired and uncomfortable, which can disappear after the disease improves; mental fatigue is accompanied by bad emotions, and when the emotions are relieved or the mood is comfortable, the fatigue will be relieved, and the mood will be depressed and depressed for a long time And without remission, it is easy to suffer from mental illness. Fatigue is the body's instinctive protective response, which can protect the body from excessive consumption or even exhaustion. Modern people feel tired due to various reasons. In the report of the World Health Organization, fatigue is listed as one of the main factors endangering human health in the 21st century, and the medical circle is paying more and more attention to fatigue year by year. Therefore, the effective prevention and treatment of fatigue has become an urgent problem to be solved.

Soybean is one of the most abundant vegetable protein sources, containing 36% to 56% protein, and is a good source of bioactive small peptides. Soybean bioactive peptides not only have the nutritional properties of soybean protein, but also have the unique physical and chemical properties of small molecule peptides. Compared with proteins, soybean peptides have smaller molecular weight and volume, so they are more hydrophilic and more soluble. In the event of excessive fatigue, in order to avoid the negative balance of muscle protein, amino acids should be supplemented from the outside in time. Since the body absorbs soybean peptides more easily than amino acids and proteins, it can quickly recover and enhance physical strength. In addition, studies have shown that soybean active peptides have physiological health functions such as antihypertensive, antioxidative, anticancer, hypolipidemic, weight loss, antiviral and antibacterial, and can be used as active ingredients in dietary supplements, functional foods and drugs, and are widely used Used in food, medicine, feed and other industries.

Contents of the invention

The object of the present invention is to provide an anti-fatigue traditional Chinese medicine composition and a preparation method thereof.

In order to achieve the above object, the present invention provides the following technical proposal: an anti-fatigue traditional Chinese medicine composition made of the following raw materials by weight: 8-12 parts of soybean peptide powder, 9-15 parts of sealwort, 3-9 parts of ginseng , jujube 6-15 parts, jujube seed 5-10 parts, lotus seeds 6-15 parts.

The anti-fatigue traditional Chinese medicine composition is made of the following raw materials in parts by weight: 8-12 parts of soybean peptide powder, 9-15 parts of sealwort, 3-9 parts of ginseng, 6-12 parts of lily, 9-30 parts of astragalus 6-12 parts of wolfberry, 10-15 parts of rehmannia, 6-15 parts of jujube, 5-10 parts of wild jujube seed, 6-15 parts of lotus seeds, 11-13 parts of yam, 6-8 parts of licorice.

The anti-fatigue traditional Chinese medicine composition is made of the following raw materials in parts by weight: 8 parts of soybean peptide powder, 9 parts of Polygonatum, 3 parts of ginseng, 6 parts of lily, 9 parts of astragalus, 6 parts of wolfberry, 10 parts of rehmannia glutinosa, 6 parts of jujube, 5 parts of jujube seed, 6 parts of lotus seeds, 11 parts of yam, 6 parts of licorice.

The anti-fatigue traditional Chinese medicine composition is made of the following raw materials in parts by weight: 12 parts of soybean peptide powder, 15 parts of Polygonatum, 3 parts of Ginseng, 12 parts of Lily, 30 parts of Astragalus, 12 parts of Lycium barbarum, 10 parts of Rehmannia glutinosa, 15 parts of jujube, 10 parts of jujube seed, 6 parts of lotus seeds, 11 parts of yam, 8 parts of licorice.

The anti-fatigue traditional Chinese medicine composition is made of the following raw materials in parts by weight: 12 parts of soybean peptide powder, 12 parts of sealwort, 8 parts of ginseng, 10 parts of lily, 22 parts of astragalus, 10 parts of wolfberry, 15 parts of rehmannia glutinosa, 8 parts of jujube, 8 parts of jujube kernel, 12 parts of lotus seeds, 12 parts of yam, 6 parts of licorice.

The anti-fatigue traditional Chinese medicine composition is made of the following raw materials in parts by weight: 10 parts of soybean peptide powder, 10 parts of sealwort, 4 parts of ginseng, 10 parts of jujube, 6 parts of jujube seed, and 8 parts of lotus seeds.

The preparation method of the anti-fatigue traditional Chinese medicine composition is as follows: (1) mix sealwort, ginseng, jujube, jujube seed and lotus seeds, add water to extract twice, filter to obtain water extract, centrifuge, filter to get the filtrate (2) After adding the corresponding additives, add soybean peptide powder, concentrate the filtrate to a relative density of about 1.05g/mL, centrifuge, fill and sterilize.

The preparation method of the anti-fatigue traditional Chinese medicine composition is as follows: (1) mix sealwort, ginseng, lily, astragalus, wolfberry, rehmannia glutinosa, jujube, jujube seed, lotus seed, yam and licorice, add water to extract twice, filter (2) After adding the corresponding additives, add soybean peptide powder, concentrate the filtrate to a relative density of about 1.05g/mL, centrifuge, fill and sterilize.

The anti-fatigue Chinese medicine composition, the dosage form of the Chinese medicine composition is oral liquid; the extraction method described in step (1) is reflux extraction, and the amount of solvent is 10 times; the temperature of the reflux extraction is 100 ° C, every The time for secondary reflux extraction is 90min; before the centrifugation described in step (1), it is necessary to add additives to the aqueous solution to mix, and keep warm at 40-50°C for 30-60min; the additives include chitosan, sodium citrate and one or more of sodium alginate; the centrifugation parameter is 10000r/min, centrifuged for 10min; the sterilization method described in step (2) is moist heat sterilization.

The application of the traditional Chinese medicine composition in the preparation of anti-fatigue health products.

Soybean peptide powder was purchased from Liaoning Taiai Peptide Bioengineering Technology Co., Ltd., the production batch number is 20211204-1.

Polygonatum is the dried rhizome of Polygonatumkingianum Coll. et Hemsl., Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua. Function cures mainly for invigorating qi and nourishing yin, invigorating the spleen, nourishing the lungs, and nourishing the kidney. For spleen and stomach qi deficiency, body fatigue and fatigue, insufficient stomach yin, dry mouth and lack of food, dry cough due to lung deficiency, labor cough and hemoptysis, insufficient essence and blood, sore waist and knees, premature graying of beard and hair, internal heat and quenching thirst.

Ginseng is the dried root and rhizome of Panax ginseng C.A.Mey. It is mostly excavated in autumn, washed and sun-dried or dried. Functions and indications are to invigorate vital energy, restore pulse and solidify, invigorate the spleen and lung, promote body fluid and nourish blood, soothe the nerves and improve intelligence. It is used for physical weakness, cold extremities, slight pulse, spleen deficiency, lack of food, lung deficiency, coughing, thirsty wounds, internal heat and thirst, and deficiency of qi and blood.

Lily is the dry fleshy scale leaves of Lilium lancifolium Thunb., Lilium brownii F.E. Brown var. viridulum Baker or Lilium pumilum DC. Function cures mainly for nourishing yin and moistening lung, clearing away heart-fire and calming nerves. It is used for dry cough due to yin deficiency, hemoptysis due to overwork, restlessness and palpitation due to deficiency, insomnia and dreaminess, and trance.

Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. Functions and indications are to invigorate qi and promote yang, strengthen the surface and stop sweating, diuresis and swelling, promote body fluid and nourish blood, promote stagnation and relieve numbness, relieve toxin and expel pus, astringe sores and promote granulation.

Lycium barbarum is the mature fruit of Lyciumchinense Miller, a plant of the Solanaceae family. Harvest the fruit when it is ripe in summer and autumn, remove the stalk, put it in a cool place to dry until the skin becomes wrinkled, and then expose to the sun until the skin is dry and hard, and the flesh is soft. In case of rainy weather, it can be dried with low heat. Lycium barbarum has a variety of health effects, and it is a dual-purpose food for medicine and food approved by the Ministry of Health. Moderate consumption is good for health, and it can clear liver and improve eyesight when combined with chrysanthemum and qi tea.

Rehmannia glutinosa is the fresh or dried tuber root of Rehmannia glutinosa Libosch. Dig in autumn, remove reed heads, fibrous roots and silt, and use fresh; or slowly bake rehmannia glutinosa until about 80% dry. Function cures mainly: fresh rehmannia glutinosa clears away heat and promotes fluid production, cools blood and stops bleeding. For febrile disease impairing yin, crimson tongue and polydipsia, hot toxin hair spots, vomiting blood, epistaxis, sore throat. Radix Rehmannia clears heat and cools blood, nourishes yin and promotes body fluid. It is used for heat entering the camp and blood, warm toxins to cause spotting, vomiting blood and epistaxis, febrile disease impairing yin, crimson tongue polydipsia, fluid impairing constipation, yin deficiency and fever, bone steaming and labor heat, internal heat and quenching thirst.

Jujube is the ripe fruit of Ziziphus jujuba Mill. Harvest in autumn when the fruit is ripe. Pick out impurities and dry in the sun. Or bake until the skin is soft, and then dry it in the sun. Or boil it in water first, so that the pulp is soft and the skin is not shrunk, then pick it up and dry it in the sun. Functions and indications are: invigorating the spleen and harmonizing the stomach, replenishing qi and promoting body fluid, regulating camp and health, and detoxifying medicine. Treat deficiency of the stomach, lack of food, weak spleen and loose stools, insufficiency of qi, blood and body fluid, disharmony between the camp and the defense, and palpitations. The woman is dirty.

Ziziphus jujuba Mill.var.spinosa (Bunge) Hu exH.F.Chou is the dry mature seed of Ziziphus jujuba Mill.var.spinosa (Bunge) Hu exH.F.Chou. Functions and indications are nourishing the heart and nourishing the liver, calming the mind and calming the nerves, suppressing sweating, and promoting body fluid. Used for insomnia due to deficiency, palpitation and dreaminess, hyperhidrosis due to physical weakness, and thirsty wounds.

The lotus seeds are the dry mature seeds of Nelumbo nucifera Gaertn., a plant of the water lily family. Function cures mainly to invigorate the spleen and stop diarrhea, stop belt, tonify the kidney and astringent essence, nourish the heart and calm the nerves. For spleen deficiency diarrhea, leukorrhagia, nocturnal emission, palpitation and insomnia.

Yam tastes sweet and flat, and belongs to the spleen, lung, and kidney meridian. It is an important nourishing medicine.

Licorice is the dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of the leguminous plant Glycyrrhiza uralensis Fisch. Function cures mainly for invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and relieving pain, coordinating various medicines.

Compared with prior art, the beneficial effect of the present invention is:

1. The earliest description of the meaning of fatigue appeared in the "Huangdi Neijing". Sweating". In addition, in ancient books, there are sayings such as "stop extreme", "tired extreme", "burnout", "sleepy thin", etc. For example, in "Six Festivals of Zangxiang Lun", there is "the liver is the root of the extreme, and the residence of the soul." "Three Kingdoms" says that "the tune and Fu are still there, and you are extremely tired every day." In "Shi Yi De Xiao Fang" there are "men and women's qi and blood are injured, and their limbs are tired." According to records in ancient books, fatigue is mainly attributed to liver function, fatigue and loss of vitality. There is a close relationship between the liver and fatigue, the liver governs the tendons, and is the foundation of the extreme. "Su Wen·Ancient Innocence Theory" "Husband... Seven or eight liver qi declines, and the tendons cannot move", which explains the relationship between the liver and tendons. First, tendons belong to The liver is in charge, and under physiological conditions, the functional activities of tendons depend on the liver qi; the second is that the liver qi is weak, and if the tendons cannot be nourished, the tendons cannot move. Therefore, clinical research and treatment methods mostly start with regulating visceral functions. The whole prescription Polygonatum, Ginseng, Lily, Astragalus, Lycium barbarum, and Rehmannia tonify Qi and nourish Yin, invigorate the spleen, moisten the lungs, and benefit the kidneys are monarch drugs; jujube, yam, and licorice tonify Zhongyi Qi, nourishing blood and calming the nerves, are ministerial medicines; Suanzaoren and lotus seeds calm the mind and calm the nerves, and serve as assistants to each other. Combined with soybean peptide powder, while supplementing human nutrition, it can replenish energy, replenish qi and strengthen the foundation, calm the mind and calm the nerves, and play the role of nourishing yin and promoting body fluid. The combined use of the two types can improve the anti-fatigue function, and also show the miraculous effect of clearing the heart and calming the nerves and improving immunity. And the raw material of the present invention is natural, is the dual-purpose raw material of medicine and food, the characteristics of long-term use without toxic and side effects. The preparation method has stable process, high preparation efficiency and strong operability, and is suitable for large-scale industrial production.

2. The absorption speed of soybean polypeptide is fast and the absorption is strong, which is 3 times that of amino acid. It is absorbed directly without degradation, and compared with protein or amino acid, soybean polypeptide has lower osmotic pressure, which can increase to a certain extent. protein absorption. Soybean peptides can form metal chelates with these mineral elements to keep them in a soluble state, avoiding the combination with phytic acid, oxalic acid, fiber and tannin to form precipitation, so that the solubility, absorption rate and delivery speed of mineral elements are all improved. Significantly improved, greatly improving their bioavailability. Combining traditional Chinese medicine compound with soybean peptide powder can improve the anti-fatigue effect and guarantee it more comprehensively.

Detailed ways

Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Example 1:

Take 8g of soybean peptide powder, 9g of sealwort, 3g of ginseng, 6g of lily, 9g of astragalus, 6g of wolfberry, 10g of rehmannia glutinosa, 6g of jujube, 5g of jujube seed, 6g of lotus seed, 11g of yam, and 6g of licorice. The preparation method is (1) combine sealwort, Mix ginseng, lily, astragalus, wolfberry, rehmannia glutinosa, jujube, jujube seed, lotus seed, yam, and licorice, add water to extract twice, filter to obtain water extract, centrifuge, and filter to get the filtrate. (2) After adding the corresponding additives, add soybean peptide powder, concentrate the filtrate to a relative density of about 1.05g/mL, centrifugally fill it, prepare it into an oral liquid, and sterilize it.

Example 2:

Weigh the raw materials according to the weight of the following unilateral medicinal flavors: soybean peptide powder 12g, sealwort 15g, ginseng 3g, lily 12g, astragalus 30g, wolfberry 12g, rehmannia glutinosa 10g, jujube 15g, jujube seed 10g, lotus seeds 6g, yam 11g, licorice 8g.

The preparation method is the same as in Example 1.

Example 3: Take soybean peptide powder 12g, sealwort 12g, ginseng 8g, lily 10g, astragalus 22g, wolfberry 10g, rehmannia glutinosa 15g, jujube 8g, jujube seed 8g, lotus seeds 12g, yam 12g, licorice 6g.

The preparation method is the same as in Example 1.

Example 4: Take soybean peptide powder 10g, sealwort 10g, ginseng 4g, jujube 10g, jujube seed 6g, lotus seed 8g, the preparation method is (1) mix sealwort, ginseng, jujube, jujube kernel, lotus seed medicinal materials, add water to extract For the second time, filter to obtain a water extract, centrifuge, and filter to obtain the filtrate. (2) After adding the corresponding additives, add soybean peptide powder, concentrate the filtrate to a relative density of about 1.05g/mL, centrifugally fill it, prepare it into an oral liquid, and sterilize it.

Comparative example implementation 1:

Weigh the crude drug according to the weight of the following unilateral medicinal taste: take Polygonatum 9g, Ginseng 3g, Lily 6g, Astragalus 9g, Lycium barbarum 6g, Rehmannia glutinosa 10g, Jujube 6g, Ziziphus jujube kernel 5g, Lotus seed 6g, Chinese yam 11g, Licorice 6g, preparation method (1) Mix sealwort, ginseng, lily, astragalus, medlar, rehmannia glutinosa, jujube, jujube seed, lotus seed, yam, and licorice, add water to extract twice, filter to obtain water extract, centrifuge, and filter to get the filtrate. (2) After adding corresponding additives, the filtrate is concentrated to a relative density of about 1.05 g/mL, centrifugally filled, prepared into an oral liquid, and sterilized.

Experimental example 1: Research on the anti-fatigue effect of the present invention

1. Experimental materials:

Animals: 60 healthy SD mice, male, clean grade, weighing 18-22g.

Medicine: According to the random number table method, it is divided into Example 3 group, Example 4 group, Comparative Example 1 group, soybean peptide powder group.

2. Method:

2.1 Animal grouping and administration

First, 60 mice were divided into 5 groups (group 3 of example, group 4 of example, group 1 of comparative example, soybean peptide powder group, and blank control group), each group of mice had 2 cages, and each cage contained 6 mice.

2.2 Dosage design: calculated according to the dose conversion relationship between experimental animals and humans, the dosage of Example 3 group is prepared according to crude drug group 23.7g/kg; the dosage of Example 4 group is prepared according to crude drug group 8.4g/kg; Ratio 1 group dosage is prepared according to crude drug group 13.5g/kg; soybean peptide powder group dosage is prepared according to crude drug group 1.4g/kg; with 0.10mL/10g gavage volume is made into corresponding administration solution (blank control group was given distilled water).

2.3 Test method: After pre-swimming, the mice were weighed and divided into groups. Orally administer the test substance once a day according to the above dose, and after 12 consecutive days, carry out the determination of various indicators, the method is as follows:

Weight-bearing swimming test: 30 minutes after the last administration of the test substance, a weight-bearing (5% body weight lead foil) swimming test was performed on the mice. The water temperature was 25°C. The swimming time of each group of mice was recorded, and the average swimming time of each group was calculated. The results were compared with those of the control group. ANOVA was performed for comparison.

Determination of serum urea nitrogen: 60 minutes after swimming, the eyeball was pulled out to collect blood, and the serum urea nitrogen was measured according to the requirements of the kit, and the results were compared with the control group by analysis of variance.

Hepatic glycogen determination: after blood collection, the mice were killed, the liver was dissected, and 100 mg of liver was weighed according to the standard, and the liver glycogen was determined according to the requirements of the kit. The results were compared with the control group by analysis of variance.

3 Experimental results

3.1 Determination of weight-bearing swimming time in mice

The impact of each drug group on the body weight of the mice in table 1

In Table 1, there was no significant difference between the body weight gain of mice in each drug group and the control group (p>0.05).

The impact of table two traditional Chinese medicine composition on the weight-bearing swimming of each group of mice

It can be seen from Table 2 that the weight-bearing swimming time of mice in each drug group was longer than that of the control group. Through analysis of variance, there is a high degree of significance (p<0.05) between Example 3, Group 4 and the soybean peptide powder group and the control group, and there is no significant difference between the comparison group and the control group (p>0.05).

3.2 Determination of serum urea nitrogen in mice

The impact of table three Chinese medicine composition on serum urea nitrogen content of each group of mice

Table 3 shows that the serum urea nitrogen content of mice in each drug group was significantly lower than that of the control group. Through analysis of variance, there are highly significant (p<0.01) between embodiment 3 groups, 4 groups and the control group; There is a certain significance (p<0.05) between the soybean peptide powder group and the control group. Not significant (p>0.05).

3.3 Determination of mouse liver glycogen

Table 4 Effects of traditional Chinese medicine composition on liver glycogen content of mice in each group

It can be seen from Table 4 that the small liver glycogen content in each dose group was significantly higher than that in the control group. Through analysis of variance, there is significant difference between embodiment 3 groups, 4 groups and the control group (p<0.01, p<0.05); there is no significant difference between the control group and the soybean peptide powder group and the control group (p>0.05) .

4 Experimental conclusions:

After strenuous exercise, because the moving muscles break the energy balance at rest, the catabolism of protein and amino acid is strengthened, and the nucleotide metabolism is strengthened at the same time, so that the urea nitrogen in the blood increases. Blood urea nitrogen after exercise can be used as one of the indicators of anti-fatigue effect; sugar is the main source of energy during muscle activity, and about 2 hours of high-intensity exercise, glycogen is nearly exhausted. The exhaustion of physical strength during long-term intense exercise always occurs at the same time as the exhaustion of glycogen, so the content of glycogen can indicate the speed or degree of fatigue, and provide more energy for the body by increasing liver glycogen reserves, so as to achieve the effect of anti-fatigue. Purpose: The present invention compares the group of Example 3, Group of Example 4, Group of Comparative Example, soybean peptide powder group and the blank control group, and finds that the drug group can significantly prolong the swimming time of mice and reduce the serum urea nitrogen of fatigued mice content and increase liver glycogen content. Compared with Example 3 group, although the prescription of Example 4 group has been simplified, the effect is still obvious, and after the soybean peptide powder is combined with the traditional Chinese medicine composition, the effect is obviously better than that of using the traditional Chinese medicine composition or soybean peptide powder alone, indicating that The compatibility of the traditional Chinese medicine composition and the soybean peptide powder has a synergistic effect.

Claims (10)

1. An anti-fatigue Chinese medicine composition, characterized in that: it is made of the following crude drugs in parts by weight: 8-12 parts of soybean peptide powder, 9-15 parts of sealwort, 3-9 parts of ginseng, and 6-15 parts of jujube , jujube seed 5-10 parts, lotus seeds 6-15 parts. 2. The anti-fatigue Chinese medicine composition according to claim 1, characterized in that: it is made of the following raw materials in parts by weight: soybean peptide powder 8-12 parts, Polygonatum 9-15 parts, ginseng 3-9 parts, 6-12 parts of lily, 9-30 parts of astragalus, 6-12 parts of wolfberry, 10-15 parts of rehmannia glutinosa, 6-15 parts of jujube, 5-10 parts of jujube seed, 6-15 parts of lotus seeds, 11-13 parts of yam, 6-8 parts of licorice. 3. The anti-fatigue Chinese medicine composition according to claim 2, characterized in that it is made of the following raw materials in parts by weight: 8 parts of soybean peptide powder, 9 parts of sealwort, 3 parts of ginseng, 6 parts of lily, 9 parts of astragalus 6 parts of wolfberry, 10 parts of rehmannia, 6 parts of jujube, 5 parts of jujube kernel, 6 parts of lotus seeds, 11 parts of yam, and 6 parts of licorice. 4. The anti-fatigue Chinese medicine composition according to claim 2, characterized in that it is made of the following raw materials in parts by weight: 12 parts of soybean peptide powder, 15 parts of sealwort, 3 parts of ginseng, 12 parts of lily, 30 parts of astragalus 12 parts of wolfberry, 10 parts of rehmannia, 15 parts of jujube, 10 parts of jujube seed, 6 parts of lotus seeds, 11 parts of yam, and 8 parts of licorice. 5. The anti-fatigue Chinese medicine composition according to claim 2, characterized in that it is made of the following raw materials in parts by weight: 12 parts of soybean peptide powder, 12 parts of sealwort, 8 parts of ginseng, 10 parts of lily, 22 parts of astragalus 10 parts of wolfberry, 15 parts of rehmannia, 8 parts of jujube, 8 parts of wild jujube kernel, 12 parts of lotus seeds, 12 parts of yam, 6 parts of licorice. 6. The anti-fatigue traditional Chinese medicine composition according to claim 1, characterized in that it is made of the following raw materials in parts by weight: 10 parts of soybean peptide powder, 10 parts of sealwort, 4 parts of ginseng, 10 parts of jujube, wild jujube 6 parts of kernels and 8 parts of lotus seeds. 7. the anti-fatigue Chinese medicine composition according to claim 1, is characterized in that: the preparation method is: (1) Mix sealwort, ginseng, jujube, wild jujube seed, and lotus seed medicinal materials, add water to extract twice, filter to obtain a water extract, centrifuge, filter to get the filtrate; (2) After adding the corresponding additives, add soybean peptide powder, concentrate the filtrate to a relative density of about 1.05g/mL, centrifuge, fill and sterilize. 8. the anti-fatigue Chinese medicine composition according to claim 2, is characterized in that: the preparation method is: (1) Mix sealwort, ginseng, lily, astragalus, medlar, rehmannia glutinosa, jujube, jujube seed, lotus seed, yam, and licorice, add water to extract twice, filter to obtain water extract, centrifuge, and filter to get the filtrate; (2) After adding the corresponding additives, add soybean peptide powder, concentrate the filtrate to a relative density of about 1.05g/mL, centrifuge, fill and sterilize. 9. The anti-fatigue Chinese medicine composition according to claim 7 or 8, characterized in that: the dosage form of the Chinese medicine composition is an oral liquid; The extraction method described in step (1) is reflux extraction, and the amount of solvent is 10 times; the temperature of the reflux extraction is 100°C, and the time of each reflux extraction is 90min; Before the centrifugation described in step (1), it is necessary to add additives to the aqueous solution to mix and incubate at 40-50°C for 30-60min; the additives include one of chitosan, sodium citrate and sodium alginate or several kinds; the centrifugation parameter is 10000r/min, centrifuged for 10min; The sterilization method described in step (2) is moist heat sterilization. 10. the application of Chinese medicine composition according to claim 1 or 2 in the preparation of anti-fatigue health products.