CN102552537B - Chinese medicinal composition for treating qi and blood loss - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating deficiency of qi and blood. The weight parts of the raw materials are: 50-200 parts of sheep embryo freeze-dried powder, 1-20 parts of wolfberry fruit, 1-20 parts of tortoise flower, Hawthorn 1-20 parts, kudzu root 1-20 parts. The present invention uses sheep embryo freeze-dried powder as the main raw material, which is easy to obtain and low in cost. At the same time, other four-flavor medicinal and edible medicinal materials with the same origin are selected according to the traditional Chinese medicine theory. Blood deficiency can play the role of nourishing qi and blood, eliminating diseases and strengthening the body, prolonging life, treating both symptoms and root causes, and has no toxic and side effects, and is not easy to relapse after patients use it.

Description

A kind of traditional Chinese medicine composition for treating deficiency of Qi and blood

technical field

The invention relates to a traditional Chinese medicine composition for treating deficiency of qi and blood, and belongs to the field of traditional Chinese medicines.

Background technique

Qi and blood loss is generally manifested as dizziness, lack of energy, lazy speech, fatigue and spontaneous sweating, pale or sallow complexion, palpitations, insomnia, pale and tender tongue, thready and weak pulse, etc. It is clinically diagnosed as anemia, sub-health, premature aging, and postpartum anemia , frailty, irregular menstruation, amenorrhea, etc. According to the traditional medical theory of the motherland, although the symptoms of these diseases are different, the mechanism of their pathogenesis can be attributed to the deficiency of qi and blood, which can be collectively classified as "asthenia". Asthenia is due to various reasons such as weak endowment, acquired malnutrition, exogenous pathogenic factors and internal injuries, etc., resulting in the decline of visceral functions, loss of qi, blood, yin and yang, and is no longer the main cause of a disease for a long time. According to the theory of traditional Chinese medicine, the treatment of qi and blood deficiency should focus on regulating yin and yang, replenishing qi and blood, and promoting the recovery of viscera functions.

At present, the traditional Chinese medicines used to treat qi and blood loss are mainly composed of ginseng, Codonopsis pilosula, Astragalus, Poria cocos, yam and other qi-tonifying medicines, as well as blood-tonifying medicines such as angelica, jujube, and donkey-hide gelatin. Pills, composed of Codonopsis pilosula, Atractylodes macrocephala (stir-fried), Poria, Radix Glycyrrhizae, Angelica, Rhizoma Chuanxiong, Radix Paeoniae Alba (stir-fried with wine), Rehmannia glutinosa, Radix Radix Radix Radix Sunburne and cinnamon, used for qi and blood deficiency, pale complexion, shortness of breath, palpitation, dizziness Sweating, fatigue, limbs are not warm, heavy menstruation, but this formula contains cinnamon, which is a warming medicine, so people with excess heat should not use it. At the same time, clinical experiments have proved that exogenous wind-cold, wind-heat, excess heat and internal excess should not be used It should not be taken together with cold medicines, so the use of this medicine is limited.

Sheep fetus, also known as sheep placenta, its nutrient composition is basically the same as that of human placenta, and its nutritional structure is closest to human placenta. Its reasonable natural structure and particularly rich nutrient content have become the first choice for animal placenta, which widely exists in Northwest my country. It is mainly used to extract sheep placenta, which is used in the field of cosmetics, and there are few applications and developments in the preparation of medicines as raw materials of traditional Chinese medicine. Chinese patent document CN101804165A discloses a preparation for detoxifying the kidneys, strengthening internal organs, enhancing physical fitness and delaying aging. In addition to sheep fetal powder, the preparation also contains more than 80 traditional Chinese medicines such as Cordyceps militaris, velvet antler, Codonopsis pilosula, Caulis Spatholobus, Rehmannia glutinosa, etc. , the formula of this prescription is complicated, and simultaneously contains valuable medical materials such as Cordyceps sinensis, ginseng, American ginseng, etc., and the cost is high. the

Contents of the invention

The technical problem to be solved by the present invention is that the traditional Chinese medicine formula made from sheep embryos in the prior art is complex and costly. To provide a traditional Chinese medicine combination with simple formula, low treatment cost and wide application range for treating qi and blood loss substances and their preparation methods.

The invention provides a traditional Chinese medicine composition for treating qi and blood deficiency, which is realized through the following technical scheme. The weight parts of the raw materials of the composition are: 50-200 parts of sheep embryo freeze-dried powder, 1-20 parts of Lycium barbarum 1-20 parts of Toi Toi flower, 1-20 parts of hawthorn, 1-20 parts of kudzu root.

The parts by weight of the preferred Chinese medicine composition raw material of the present invention are: 80-150 parts of sheep embryo freeze-dried powder, 2-10 parts of medlar, 2-10 parts of tortoise flower, 2-10 parts of hawthorn, 1-20 parts of kudzu root .

The most preferred parts by weight of the crude drug of the traditional Chinese medicine composition of the present invention are: 92 parts of sheep embryo freeze-dried powder, 2 parts of medlar, 2 parts of tortoise flower, 2 parts of hawthorn, and 2 parts of kudzu root.

The sheep embryo freeze-dried powder is obtained by subjecting the sheep embryo to freeze-drying treatment at a temperature of -80 to +50° C. for 20-30 hours and then crushing.

The traditional Chinese medicine composition of the present invention can be made into pills, tablets, capsules, syrups, granules, powders and liquors.

The preparation method of Chinese medicine composition of the present invention, comprises the steps:

a) Weigh each API in specific parts by weight for use;

b) Crush wolfberry fruit, toi toi flower, hawthorn, and kudzu root into fine powder;

c) The above fine powder is mixed with sheep embryo freeze-dried powder to obtain the active ingredient of the medicine of the present invention.

The sheep embryo freeze-dried powder is obtained by subjecting the sheep embryo to freeze-drying treatment at a temperature of -80 to +50° C. for 20-30 hours, and then crushing. The particle size of the fine powder is 500-1200 mesh.

The invention also relates to the application of the traditional Chinese medicine composition in the preparation of medicines for treating Qi and blood deficiency.

The principles and methods of traditional Chinese medicine for treating qi and blood deficiency mainly include strengthening the spleen and harmonizing the stomach, nourishing qi and generating blood, nourishing the kidney and generating blood, removing blood stasis and generating blood, and detoxifying and generating blood. ``

Sheep embryo is sweet and warm in nature. It is a kind of flesh and blood product that nourishes essence and blood. It is widely used in Inner Mongolia and is listed as the main medicine. Lycium barbarum is sweet in taste and mild in nature. The yang in the kidney, together with Pueraria lobata root, strengthens the power of strengthening the waist and strengthening the bones, and is adjuvant altogether. Experiments have proved that daily administration of the decoction to mice can promote hematopoietic function.

Toi Dai flowers are bitter, sour and slightly cold, and they belong to the Spleen, Lung and Large Intestine Meridian. . Experiments have proved that it can promote the secretion of digestive glands, especially the secretion of lipase, which is better for digesting fat.

The above five flavors belong to the same source of medicine and food. When used together, they can nourish qi and blood, strengthen the waist and bones, nourish but not greasy, and prolong life. For men, women and children who have lost qi and blood and need to nourish qi and blood, cure diseases and strengthen the body All available. It can also be effective for those who are distended and stuffy in the chest ribs, unable to eat and have trouble defecating.

The present invention has the following advantages:

The present invention selects sheep embryos as raw materials, which are easy to obtain and low in cost. At the same time, according to the theory of traditional Chinese medicine, wolfberry, tortoise flower, hawthorn and kudzu root are selected, which belong to medicinal and edible medicinal materials of the same origin, and the formula is simple. It can be used to treat deficiency of qi and blood, tonify qi and blood, eliminate diseases and strengthen the body, and prolong life. It treats both symptoms and root causes, and has no toxic and side effects. The traditional Chinese medicine composition of the present invention selects the toi toi flower to regulate qi in the middle, eliminate food and eliminate swelling, and is equipped with hawthorn to promote qi and disperse blood stasis, and reconcile qi and blood, which can effectively promote the secretion of digestive glands, especially promote the secretion of lipase and digest fat, thereby promoting The absorption of nutrients by the body, without the use of large tonics such as Cordyceps sinensis and ginseng, plays the role of nourishing qi and blood, eliminating diseases and strengthening the body, and prolonging life. The traditional Chinese medicine composition of the present invention further selects the freeze-dried powder of sheep embryos as the raw material drug, thereby fully retaining the active ingredients of sheep embryos through freeze-drying technology, avoiding the destruction of the active ingredients caused by direct drying of sheep embryos problem, thereby ensuring the effective active ingredients of the Chinese medicine composition and improving its curative effect.

Detailed ways

Example 1

Weigh 50g of sheep embryo freeze-dried powder, 1g of medlar, 1g of tortoise flower, 1g of hawthorn, and 1g of kudzu root for later use.

Grind wolfberry fruit, toi toi flower, hawthorn, and kudzu root into 500 mesh fine powder respectively;

The above fine powder is mixed with sheep embryo freeze-dried powder and packed into capsules to obtain the capsules of the present invention.

Example 2

Weigh 200g of sheep embryo freeze-dried powder, 20g of medlar, 20g of tortoise flower, 20g of hawthorn, and 20g of kudzu root for later use.

Grind wolfberry fruit, toi toi flower, hawthorn, and kudzu root into 1200 mesh fine powder respectively;

Mix the above-mentioned fine powder with the freeze-dried sheep embryo powder, add 150 g of honey, agglomerate into a pellet, and obtain the pill of the present invention.

Example 3

Weigh 92g of sheep embryo freeze-dried powder, 2g of medlar, 2g of tortoise flower, 2g of hawthorn, and 2g of kudzu root for later use.

Grind wolfberry fruit, toi toi flower, hawthorn, and kudzu root into 850 mesh fine powder respectively;

The above fine powder is mixed with sheep embryo freeze-dried powder and packed into capsules to obtain the capsules of the present invention.

Example 4

Weigh 80g of sheep embryo freeze-dried powder, 2g of medlar, 2g of tortoise flower, 2g of hawthorn, and 2g of kudzu root for later use.

Grind wolfberry fruit, toi toi flower, hawthorn, and kudzu root into 1000 mesh fine powder respectively;

The above fine powder is mixed with sheep embryo freeze-dried powder, ethanol is added as a binder, starch is added as a filler, and the granule of the present invention is obtained by pressing.

Example 5

Weigh 150g of sheep embryo freeze-dried powder, 10g of medlar, 10g of tortoise flower, 10g of hawthorn, and 10g of kudzu root for later use.

Grind wolfberry fruit, toi toi flower, hawthorn, and kudzu root into 700 mesh fine powder respectively;

The above-mentioned fine powder is mixed with sheep embryo freeze-dried powder, added with auxiliary materials to make granules, dried and pressed into tablets to obtain the tablet of the present invention.

The sheep embryo freeze-dried powder in the above-mentioned examples is commercially available sheep embryo freeze-dried powder sold by Soochow Zhumuqin Banner Yueyi Biotechnology Co., Ltd. In addition, the freeze-dried powder of sheep embryos in the traditional Chinese medicine composition of the present invention can also use any commercially available freeze-dried powder of sheep embryos. The freeze-dried powder of sheep embryos can also be freeze-dried sheep embryos at a temperature of -80 to +50°C for 20-30 hours and then pulverized.

Experimental example

In order to show the therapeutic effect of this traditional Chinese medicine composition on men, women, old and young people who suffer from Qi and blood deficiency and need to nourish Qi and nourish blood, get rid of illness and strengthen the body, the present invention has undergone systematic clinical observation of 100 cases, and recorded their medical history, disease condition, age and original treatment method to compare the curative effects. experiment.

Among the 100 patients, 30 suffered from anemia caused by deficiency of Qi and blood, 15 suffered from sub-health, 35 suffered from postpartum physical weakness, and 20 suffered from premature aging. Among the above patients, most of them showed pain, swelling, and stiffness at the affected site. Some patients have a long course of more than ten years, and a variety of treatment methods have no obvious effect.

The criteria for judging clinical efficacy are:

Clinical cure: the original symptoms disappeared.

Markedly effective: the original symptoms partially disappeared.

Improvement: the original condition has been alleviated.

Ineffective: no change in symptoms and signs.

The administration method is: orally administer the capsule prepared in Example 3 to the patient.

Course of treatment: 15 days as a course of treatment, used twice a day.

The results of clinical experiments show that the original symptoms can be obviously relieved by using the traditional Chinese medicine composition for only one course of treatment. According to statistics, 5% of patients with mild symptoms can be cured at one time. After one course of treatment, the cure rate reaches 95%, 5% are markedly effective or improved, and there is no invalid situation (see Table 1).

In the above-mentioned clinical experiment, hematuria routine, liver and kidney function, electrocardiogram, etc. were checked and recorded before and after the patient took the medicine, and no abnormalities were found in the comparison. It can be seen that the Chinese medicine composition has no toxic and side effects. relapsed patients.

Precautions: 1. Do not use if you have excess evil or stagnant fire in your body; 2. Do not use if you have yin deficiency and internal heat; 3. Avoid spicy food.

Comparative experiment example

Weigh 15g Cordyceps militaris, 15g antler, 20g Codonopsis, 15g Caulis Spatholobus, 20g Rehmannia glutinosa, 25g Mulberry fruit, 15g Gecko, 15g Anemarrhena, 15g Ligustrum lucidum, 15g Ginkgo biloba, 15g grape seed extract, 15g pearl powder, 15g propolis, 15g kudzu root, 16g seabuckthorn, 15g poria cocos, 20g longan meat, 15g hawthorn, 15g golden cherry, 15g coix seed, 15g peach kernel, 20g tangerine peel, 15g Polygonatum odoratum, 18g lotus leaf, 300g Tai Sui, 50g aloe vera, 40g angelica , 23g ginseng, 40g donkey-hide gelatin, 50g sheep fetus powder, 15g cordyceps sinensis, 14g ganoderma lucidum, 23g astragalus, 30g medlar, 15g whole turtle, 20g whole turtle, 25g Polygonum multiflorum, 14g prickly pear juice, 15g licorice, 13g rootless vine, 15g The formulations were prepared from bulimia, 16g sealwort, 15g dogwood, 15g epimedium, 20g American ginseng, 13g antler gum, 20g cassia seed, 16g plum flower ginseng and 15g imperial tire, according to the method disclosed in the aforementioned Chinese patent document CN101804165A. Use this preparation to carry out clinical trials to 100 routine patients with the same constitution and state of illness, give this preparation once 10ml, 2 times a day.

After taking continuously for 15 days, the results are shown in Table 2, the average cure rate can only reach 40%, and it is easy to repeat after drug withdrawal.

Although the present invention has been described in detail through the above-mentioned specific embodiments, those skilled in the art should understand that any changes in form and details made on this basis that do not exceed the scope of protection of the claims belong to The scope to be protected by the present invention.

Claims (10)

1. a pharmaceutical composition, it is characterized in that: the weight portion of said composition crude drug is: freeze-dried powder of sheep embryo 50-200 part, Fructus Lycii 1-20 part, Citrus aurantium L. var. amara Engl. 1-20 part, Fructus Crataegi 1-20 part, Radix Puerariae 1-20 part.

2. pharmaceutical composition according to claim 1, it is characterized in that: the weight portion of described crude drug is: freeze-dried powder of sheep embryo 80-150 part, Fructus Lycii 2-10 part, Citrus aurantium L. var. amara Engl. 2-10 part, Fructus Crataegi 2-10 part, Radix Puerariae 1-20 part.

3. pharmaceutical composition according to claim 2, it is characterized in that: the weight portion of described crude drug is: 92 parts of freeze-dried powder of sheep embryo, 2 parts of Fructus Lycii, 2 parts of Citrus aurantium L. var. amara Engl.s, 2 parts of Fructus Crataegis, 2 parts of Radix Puerariaes.

4. according to the arbitrary described pharmaceutical composition of claims 1 to 3, it is characterized in that: described freeze-dried powder of sheep embryo obtains for pulverizing after at-80～+ 50 ℃ of temperature, described sheep embryo being carried out to frozen dried 20-30h.

5. according to the arbitrary described pharmaceutical composition of claims 1 to 3, it is characterized in that: described Chinese medicine composition can be made pill, tablet, capsule, syrup, granule, powder, medicated wine.

6. pharmaceutical composition according to claim 4, it is characterized in that: described Chinese medicine composition can be made pill, tablet, capsule, syrup, granule, powder, medicated wine.

7. the preparation method of the arbitrary described pharmaceutical composition of claim 1 to 4, comprise the steps:

A) take by weight each crude drug stand-by;

B) Fructus Lycii, Citrus aurantium L. var. amara Engl., Fructus Crataegi, Radix Puerariae are ground into respectively to fine powder;

C) above-mentioned fine powder is mixed with freeze-dried powder of sheep embryo, obtain the active component of medicine.

8. preparation method according to claim 7 is characterized in that: described freeze-dried powder of sheep embryo obtains for pulverizing after at-80～+ 50 ℃ of temperature, described sheep embryo being carried out to frozen dried 20-30h.

9. preparation method according to claim 7, it is characterized in that: described fine powder particle diameter is the 500-1200 order.

10. the arbitrary described pharmaceutical composition of claim 1 to 4 is treated the purposes in the deficiency of both QI and blood medicine in preparation.