CN116087484A

CN116087484A - Compact high-efficiency magnetic particle immunity analyzer

Info

Publication number: CN116087484A
Application number: CN202211414733.0A
Authority: CN
Inventors: 请求不公布姓名
Original assignee: Chongqing Zhimai Medical Technology Co ltd
Current assignee: Chongqing Zhimai Medical Technology Co ltd
Priority date: 2022-11-11
Filing date: 2022-11-11
Publication date: 2023-05-09
Anticipated expiration: 2042-11-11
Also published as: CN116087484B

Abstract

The invention discloses a compact high-efficiency magnetic particle immunity analyzer, which comprises an incubation system arranged on the upper layer of a rack, wherein the incubation system comprises an incubation module and a filling ring rotatably arranged on the outer side of the periphery of the incubation module; the upper layer of the rack is provided with a sample filling system, a diluting system, a reaction cup loading system, a reagent system, a detecting system, at least one washing system and an independent mixing mechanism which are circumferentially distributed around the incubation system, wherein the reagent system comprises a reagent filling module arranged at the top of the reagent system, and a transfer system used for interaction of the reaction cup is arranged between the reaction cup loading system, the detecting system, the washing system, the independent mixing mechanism and the incubation system. The layout and the respective structures of the functional modules are mainly optimized, so that the positions of the functional modules are relatively compact, the utilization rate of the height space is increased, the occupation of the transverse volume is reduced, the miniaturization development of the whole machine is facilitated, and meanwhile, the interactive functions of the functional modules are used up to the maximum extent so as to improve the detection and analysis efficiency of the whole machine.

Description

Compact high-efficiency magnetic particle immunity analyzer

Technical Field

The invention belongs to the field of medical equipment, and particularly relates to a compact high-efficiency magnetic particle immunity analyzer.

Background

Chemiluminescent immunoassay combines a chemiluminescent assay technology with a highly specific immune reaction, and is used for detection and analysis of various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, drugs, etc. Is a latest immunoassay technology developed after the analysis of radioimmunoassay, enzyme immunoassay, fluorescence immunoassay and time-resolved fluorescence immunoassay.

The analyzer generally comprises a reaction cup loading system, a dilution system, a filling system, a reagent system, an incubation system, a washing system and a detection system, and interaction among the systems is generally completed by a corresponding transport mechanism, so that in the prior art, more such instruments are available, such as a patent with the name of "201921397151.X", a patent with the name of "a chemiluminescent instrument", and a patent with the name of "202210460925.9", a full-automatic chemiluminescent immunoassay analyzer ", which have relatively mature implementation structures for the whole process steps of analysis.

The applicant finds that in the research and development process, the main problems of the related analyzers at present are the comprehensive layout of each module and the integration of the functions of the modules, especially in the aspect of the arrangement of a transfer mechanism, the prior art has few comprehensive considerations, so that the whole structure is large in size, the effective working efficiency cannot be fully utilized, the waiting time of a single module or a plurality of modules can be prolonged, the detection efficiency of the analyzers is influenced, and the miniaturization of the analyzers is also not facilitated. Therefore, an optimization and improvement on the overall layout structure of the existing analyzer is needed, so that the components are relatively more compact, and the components are matched with each other more quickly, so that the working efficiency of the whole analyzer is improved.

Disclosure of Invention

In view of the above, the invention provides a compact high-efficiency magnetic particle immunity analyzer, which aims to solve the problems of the prior analyzer that the distribution and arrangement of each functional module are unreasonable, the whole structure is bulky and disordered, the volume is large, and the working efficiency of each module cannot be fully utilized, so that the detection efficiency of the analyzer is low.

The technical scheme is as follows:

the utility model provides a high-efficient magnetic particle immunity analysis appearance of compact, includes the frame upper strata, be close to the middle part position on the frame upper strata and be equipped with incubation system, its characterized in that: the incubation system comprises an incubation module and a filling ring which is rotatably arranged on the circumferential outer side of the incubation module, wherein filling reaction cup placing holes distributed in a circumferential array are formed in the filling ring;

sample filling system, dilution system, reaction cup loading system, reagent system, detecting system and at least one washing system and independent mixing mechanism that are circumference distribution around incubating the system have on the frame upper strata, wherein reagent system is including setting up in the reagent filling module at its top, washing system includes washing seat and the waste liquid needle lifting seat that is located this washing seat top, waste liquid needle lifting seat can be gone up and down in order to carry out the waste liquid suction relative to the washing seat, be equipped with the transfer system that is used for carrying out reaction cup interaction between reaction cup loading system, detecting system, washing system and independent mixing mechanism and the incubation system. By adopting the layout scheme, the mutual compactness of each functional module is improved, and especially the reagent filling module is arranged at the top of a reagent system, so that the height space is fully utilized, the space volume is reduced, in addition, the rotatable filling ring is adapted to each functional module, the working range of a transfer system is reduced, and the working efficiency is improved.

As preferable: the method is characterized in that: the transfer system comprises a first transfer gripper arranged between the reaction cup loading system and the incubation system; the sample filling system is close to one side of the upper layer of the rack, the dilution system comprises a dilution channel module and a dilution mixing module which are distributed at an included angle, the dilution channel module comprises a dilution trolley translation assembly and a dilution needle group lifting assembly, and the dilution trolley translation assembly comprises a dilution translation channel and a dilution trolley which is in sliding fit with the dilution translation channel; the first transfer gripper moving path is opposite to the rotating center of the filling ring and is provided with an intersection part with the dilution translation channel, and the intersection part is a dilution reaction cup loading and unloading position. By adopting the scheme, the first transfer gripper not only can be used for loading the reaction cup on the filling ring, but also can be used for loading and unloading the reaction cup on the dilution trolley.

As preferable: the dilution mixing module comprises a mixing frame and a stirring assembly arranged on the mixing frame, wherein the stirring assembly comprises a stirring rod, a dilution mixing lifting assembly and a dilution mixing translation assembly, the stirring rod is used for driving the stirring rod to lift and translate respectively, and a stirring motor for driving the stirring rod to rotate, a translation path of the dilution trolley and a translation path of the stirring rod are provided with intersection parts, and the translation path of the stirring rod is parallel to one side close to the sample filling system. By adopting the layout, the utilization efficiency of the gap between the washing system, the sample filling system and the incubation system can be improved, the whole structure is more compact, and the space waste is reduced.

As preferable: the reaction cup loading system comprises a cup discharging module, a cup discharging channel module and a cup separating module, wherein the cup discharging module is close to one corner of the upper layer of the machine frame, the cup discharging channel module is arranged along the width direction of the upper layer of the machine frame and is close to one end part of the cup discharging channel module, and the cup separating module is close to the middle part of one end of the upper layer of the machine frame. By adopting the scheme, because the cup discharging module comprises the hopper, the volume of the cup discharging module is larger, the cup discharging module is higher, the cup discharging module is relatively regular, the cup discharging module is arranged at a corner position, the utilization efficiency of the corner part can be improved, and meanwhile, other single or multiple parts can be arranged below the cup discharging module, namely, the utilization rate of the height space is improved, and the charging operation of the hopper at the later stage is also facilitated.

As preferable: the washing system, the detection system, the independent mixing mechanism and the incubation system are respectively provided with a second transferring gripper, a third transferring gripper and a fourth transferring gripper, and the moving paths of the transferring grippers are all arranged along the radial direction of the filling ring. By adopting the scheme, the moving stroke of each gripper is minimized, the space occupation is further reduced, the transferring period is shortened, and the working efficiency of the whole machine is improved.

As preferable: the reagent system comprises a reagent bin module, a reagent kit replacement module and a reagent bin base module, wherein the reagent bin module comprises a reagent bin body and a reagent bin cover, the reagent bin base module comprises a reagent system bottom plate and a reagent system top plate supported above the reagent system bottom plate, the reagent bin module is fixedly arranged on the reagent system bottom plate, the reagent kit replacement module is supported on the reagent bin base module, the reagent system bottom plate is fixedly connected with the upper layer of the frame, and the reagent filling module is fixedly arranged on the reagent system top plate. By adopting the scheme, the reagent bin base module is introduced, so that the relative independence of the reagent box replacement module and the reagent bin module is realized, no direct connection part exists structurally, and when the reagent box replacement module is installed, the two modules can be independently distributed, thereby being beneficial to the later disassembly, assembly and maintenance.

As preferable: the reagent bin cover is at least provided with a loading and unloading port A, and the top plate of the reagent system is provided with an exposure port; the kit replacement module comprises a replacement gripper unit and a replacement turntable unit, wherein the replacement turntable unit comprises a storage plate and a station rotation driving mechanism, the station rotation driving mechanism is used for driving the storage plate to rotate between a loading and unloading station and an avoidance station, the storage plate is located under the replacement gripper unit when the storage plate is located at the loading and unloading station, and the storage plate deviates from the exposure port when the storage plate is located at the avoidance station. By adopting the scheme, when the storage plate is in the avoidance station, the replacement gripper unit can extend into the reagent bin to grasp and put the reagent kit on the reagent disc, and when the storage plate is in the loading and unloading station, the replacement gripper unit can put the reagent kit taken out from the reagent bin on the storage plate, and also can grasp a new reagent kit from the storage plate to prepare to put into the reagent bin.

As preferable: the loading and unloading port A is provided with a cover plate C which is matched with the loading and unloading port A, and the cover plate C is rotatably arranged on a top plate of the reagent system;

the reagent bin cover is provided with a temporary storage groove at one side of the loading and unloading port A, the cover plate C is provided with a stop part, at least part of the stop part coincides with the top plate of the reagent system, and the cover plate C can rotate relative to the reagent bin cover so that the loading and unloading port A is at least partially opposite to the exposure port, the cover plate C rotates to fall into the temporary storage groove, or the loading and unloading port A rotates to the outer side of the top plate of the reagent system relative to the cover plate C, and the cover plate C shields the loading and unloading port A. By adopting the scheme, only one loading and unloading port A is arranged on the reagent bin cover, the position of the loading and unloading port can be changed through the rotation of the reagent bin cover and the cover plate C, when the loading and unloading port corresponds to the exposure port, the automatic online replacement can be carried out through the reagent box replacement module, and when the loading and unloading port rotates to the outer side of the cover of the top plate of the reagent system, the loading and unloading operation of the artificial reagent box can be carried out after the cover plate C rotates to the temporary storage tank, the number of openings at the top of the reagent bin cover is reduced, and the internal temperature of the reagent bin can be controlled more accurately.

As preferable: the washing system and the independent mixing mechanism are two, the sample filling system comprises two sample filling modules, the reagent filling modules comprise three reagent filling units which are parallel and just opposite to the filling ring, and a reagent needle translation path in one reagent filling unit is arranged along the radial direction of the filling ring. The whole machine adopts the structures of one reagent disk, one incubation disk, two washing disks, one detection disk, two sample needles and three reagent needles, and is matched with a transfer system formed by six grippers, so that the whole machine has excellent structural compactness, and can work in a mutually matched manner, the working efficiency of each independent functional module can be improved to the greatest extent, and waiting or transferring periods can be shortened.

As preferable: the loading and unloading port A is provided with a cover plate E which is matched with the loading and unloading port A, the cover plate E is rotatably supported on a top plate of a reagent system or/and a reagent bin cover, a rotary linkage structure is arranged between the cover plate E and the station driving mechanism, the cover plate E is opposite to the loading and unloading port A and is shielded in an initial state, and when the station driving mechanism drives the storage plate to rotate to an avoidance station, the cover plate E can be synchronously linked to rotate so that the exposed outlet is communicated with the inside of the reagent bin body. By adopting the scheme, the caliber of the loading and unloading port A can be reduced, the rotation angle of the cover plate E can be controlled conveniently, the automatic replacement and sealing requirements are met, the action that the cover plate needs to be grasped and put in the process of automatic replacement of the traditional reagent system is reduced, and the improvement of the working efficiency is facilitated.

As preferable: the washing systems are two, and the two washing systems are respectively positioned at two sides of the first transfer gripper. With the above scheme, the washing base in the washing system is generally square, and in order to match the interaction between each washing base and the incubation system, the washing base needs to be obliquely arranged, and the first transfer grip is arranged between the washing base and the incubation system, so that the idle position in the middle of the washing base can be just utilized.

As preferable: the rotation center of the cup separating disc in the cup separating module, the rotation center of the filling ring and the rotation center of the reagent disc in the reagent system are arranged on the same vertical plane, and the cup separating module and the reagent system are respectively positioned on two sides of the incubation system. With the above scheme, because the diameters of the cup separating disc, the filling ring and the reagent disc are gradually increased, the injection detection system, the washing system, the dilution system and the sample filling system can be arranged around the incubation system far away from one side of the reagent system in this way, and the arrangement mode reduces the space waste as far as possible and is convenient for the installation of other functional modules.

Compared with the prior art, the invention has the beneficial effects that:

the compact high-efficiency magnetic particle immunity analyzer provided by the invention is mainly used for optimizing the layout of functional modules and the respective structures used for analysis, and particularly matching with the unique layout of a transfer system, a reagent system and a dilution system structure, so that the positions of the modules are relatively compact, the utilization rate of the height space is enhanced, the occupation of the transverse volume is reduced, the miniaturization development of the whole machine is facilitated, the interactive functions of the modules are used up to the maximum extent, the reaction period or waiting time is shortened, and the like, thereby improving the detection analysis efficiency of the whole machine.

Drawings

FIG. 1 is a schematic diagram of the operation and principle of the present invention;

FIG. 2 is a schematic diagram of the structure of the present invention;

FIG. 3 is an isometric view of FIG. 2;

FIG. 4 is a schematic diagram of an incubation system;

FIG. 5 is a schematic illustration of a mounting structure for a filler ring;

FIG. 6 is a cross-sectional view of FIG. 5;

FIG. 7 is a perspective view of the dilution system (dilution trolley in dilution/dilution waste suction position);

FIG. 8 is an isometric view of FIG. 7 (dilution trolley in dilution blending position);

FIG. 9 is a schematic diagram of a sample filling system;

FIG. 10 is a schematic view of a sample filling module;

FIG. 11 is a schematic diagram of a cuvette loading system;

FIG. 12 is a schematic view of a transfer gripper structure;

FIG. 13 is a schematic view of a gripper head structure;

FIG. 14 is a perspective view of a reagent system;

FIG. 15 is a top view of FIG. 1;

FIG. 16 is a schematic diagram of a cartridge changing module installation;

FIG. 17 is an isometric view of FIG. 16;

FIG. 18 is a schematic diagram showing the construction of a second embodiment of a change turret unit;

FIG. 19 is a schematic view of a third embodiment of a structure and shielding means of the loading opening A;

FIG. 20 is a cross-sectional view of FIG. 19;

FIG. 21 is a schematic view showing a state in which the loading/unloading port A is opposite to the exposing port in the embodiment shown in FIG. 19;

FIG. 22 is a schematic view showing the embodiment of FIG. 19 in which the loading opening A is located outside the top plate of the reagent system and is blocked by the cover plate C;

FIG. 23 is a schematic view showing the embodiment of FIG. 19 in which the loading opening A is located outside the top plate of the reagent system and the cover plate C is opened;

FIG. 24 is a schematic view of a fourth embodiment of a structure and shielding means of the loading opening A;

FIG. 25 is a schematic view of a fifth embodiment of a structure and shielding means of the loading opening A;

FIG. 26 is a schematic illustration of the structure of a reagent mixing assembly;

fig. 27 is a schematic view of a washing system.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

Referring to fig. 1 to 27, the compact type high-efficiency magnetic particle immune analyzer comprises a frame 100, wherein the frame 100 mainly comprises a frame upper layer 110 and a frame lower layer 120 which are of rectangular structures, an incubation system 700 is arranged on the frame upper layer 110 near the middle part, the incubation system 700 comprises an incubation module 720, and a filling ring 730 rotatably arranged on the outer side of the circumference of the incubation module 720, and filling reaction cup placement holes distributed in a circumferential array are formed in the filling ring 730.

The upper layer 110 of the rack is further circumferentially distributed with a sample filling system, a dilution system 400, a cuvette loading system 200, a reagent system 600, a detection system 900, at least one washing system 800 and an independent mixing mechanism 130 around the incubation system 700, wherein the reagent system 600 comprises a reagent filling module 650 arranged at the top of the reagent system 600, and a transfer system for interaction of the cuvette is arranged between the cuvette loading system 200, the detection system 900, the washing system 800 and the independent mixing mechanism 130 and the incubation system 700.

Referring specifically to fig. 4 to 6, specifically, the incubation system 700 in the present application mainly includes an incubation base 710, the incubation base 710 is fixedly disposed on the upper frame layer 110, the incubation module 720 is rotatably supported on the incubation base 710, and the incubation base 710 is provided with an incubation disc rotation motor 721 and a filling ring rotation motor 731 for respectively driving the incubation module 720 and the filling ring 730 to rotate.

The incubation module 720 mainly comprises an incubation tray 722 and an incubation tray heat-insulating shell 727 covered on the outer side of the incubation tray 722, incubation tray 722 is provided with incubation reaction cup placement holes distributed in a circumferential array, and the distribution density of filling reaction cup placement holes is consistent with that of the incubation reaction cup placement holes, namely, the radian between every two adjacent filling reaction cup placement holes is equal to that between every two adjacent incubation reaction cup placement holes, so that the filling reaction cup placement holes are more convenient to control in the rotation process and the incubation reaction cup placement holes are in the same radial direction, and in order to further reduce the control difficulty of a gripper when in implementation, the incubation tray 722 is flush with the upper surface of the filling ring 730, and the top of the incubation tray heat-insulating shell 727 is provided with incubation loading and unloading holes 728 for placing and exposing incubation reaction cups.

The incubation base 710 is provided with a fixed base shaft 711 which is vertically and fixedly arranged, the fixed base shaft 711 is of a hollow structure, an incubation disc rotating shaft 712 is rotatably arranged in the fixed base shaft, the incubation module 720 is fixedly supported on the incubation disc rotating shaft 712, and a filling ring synchronous wheel is rotatably arranged outside the incubation module, so that the coaxial arrangement of the incubation disc and the filling ring is realized. The fixed base shaft 711 is fixedly sleeved with an incubation plate support plate 713, the incubation plate support plate 713 is of an annular hollow plate-shaped structure, the bottom of the incubation plate heat preservation shell 727 is fixedly connected with the incubation plate support plate 713 through a screw, and meanwhile, the middle of the incubation plate 722 is fixedly connected with the incubation plate rotating shaft 712 through the screw. As shown in the drawings, the rack 100 is generally used in combination with a conveying channel R, where the conveying channel R is located at one side of the lower layer 120 of the rack in the length direction, and is mainly used for conveying and recycling a sample rack, and the sample filling system is disposed near the conveying channel R.

Referring to fig. 1 with emphasis, the transfer system of the present application is composed of a plurality of transfer grippers, as shown in the drawing, a first transfer gripper 300a, a second transfer gripper 300b, a third transfer gripper 300c and a fourth transfer gripper 300d are respectively disposed between the cuvette loading system 200, the washing system 800, the detection system 900 and the independent mixing mechanism 130 and the incubation system 700, and the movement paths of the transfer grippers are all disposed along the radial direction of the filling ring 730.

According to the application, all transferring grippers are identical in structure and are different in arrangement positions and moving stay positions, all transferring grippers mainly comprise gripper heads 310, gripper translation mechanisms 320 and gripper lifting mechanisms 330 which are used for driving the gripper heads 310 to translate and lift respectively, the gripper heads 310 comprise gripper bases 311 and two vertical clamping plates 312 which are arranged right opposite, the clamping plates 312 are movably arranged relative to the gripper bases 311, driving gears 313 are arranged on the gripper bases 311, gripper motors 314 used for driving the driving gears 313 to rotate are arranged right opposite sides of the driving gears 313, racks 315 meshed with the driving gears are arranged right opposite sides of the driving gears 313, the clamping plates 312 are in one-to-one correspondence with the racks 315 and are fixedly arranged relative to each other, the driving gears 313 are driven by the gripper motors 314, the two clamping plates 312 can be driven by the racks 315 to synchronously and right and close to or far away from each other, neutrality can be fully ensured, the basic consistency of each time of the gripping positions is ensured, the working reliability is improved, the frequency adjustment is reduced, and the like.

In general, a tension spring 316 is disposed between two racks 315, the length direction of the tension spring 316 is parallel to the moving direction of the clamping plate 312, when in use, the clamping can be performed by means of the tension spring 316 under the condition of power failure of the motor except that the clamping plate is driven by a motor, and besides normal use, a certain power failure protection effect can be achieved, and the condition that the cup falls due to power failure is prevented.

Referring to fig. 1, 7 and 8, at least one washing system 800 is near a corner portion of a side where the sample filling system is located, and the dilution system 400 is generally located in an area surrounded by the washing system 800, the sample filling system and the incubation system 700, as shown in the drawing, the dilution system 400 mainly includes a dilution channel module 410 and a dilution mixing module 420 distributed in an included angle, where the dilution channel module 410 includes a dilution trolley translation assembly 430 and a dilution needle set lifting assembly 460, the dilution trolley translation assembly 430 includes a dilution translation channel 431 and a dilution trolley 432 slidingly engaged with the dilution translation channel 431, the dilution needle set lifting assembly 460 is used for driving a dilution filling needle and a waste liquid sucking needle lifting 464, and a dilution translation driving mechanism for driving the dilution trolley 432 to slide along a length direction and stay at a preset position is disposed on the dilution trolley translation assembly 430 for performing corresponding operation on a reaction cup located on the corresponding dilution trolley 432.

The dilution mixing module 420 comprises a mixing rack 421 and a stirring assembly 440 arranged on the mixing rack 421, wherein the stirring assembly 440 comprises a stirring rod 441, a dilution mixing lifting assembly 442 and a dilution mixing translation assembly 443 which are respectively used for driving the stirring rod 441 to lift and translate, and a stirring motor 444 for driving the stirring rod 441 to rotate, a translation path of the dilution trolley 432 and a translation path of the stirring rod 441 are provided with an intersection part, and dilution mixing operation of a diluent and a sample liquid can be completed at the intersection part.

The mixing rack 421 is arranged in parallel with the conveying channel R, that is, the translation path of the stirring rod 441 is parallel to one side close to the sample filling system, that is, the stirring rod 441 is arranged in parallel with the conveying channel R, the second transferring gripper 300b spans over the dilution translation channel 431, the second transferring gripper 300b can interactively transfer the reaction cups on the washing system 800 and the incubation system 700, and meanwhile, the second transferring gripper can be used for grabbing the lost cups of the reaction cups which are positioned on the dilution translation channel 431 and used for completing solid-liquid separation after dilution sampling.

In this application puddler 441 still disposes and washs cup 450, as shown, washs cup 450 and is located puddler 441 below, and when dilution mixing translation subassembly 443 drove puddler 441 translation, can be located and washs cup 450 directly over to drive it and stretch into and wash cup 450 through dilution mixing lifting unit 442 and wash. The stirring rod 441 is mainly used for cleaning and maintaining the stirring rod, the stirring rod 441 stretches into the cleaning cup 450 to be soaked and cleaned, the risk of carrying pollution by the stirring rod 441 is reduced, and the stirring rod 441 is in a rotating state in the cleaning descending and ascending processes, so that the cleaning effect can be further improved, and the carrying pollution is reduced.

Referring to fig. 11, the reaction cup loading system 200 of the present application mainly includes a cup discharging module 210, a cup discharging channel module 220 and a cup separating module 230, where the cup discharging module 210 is close to a corner of the upper layer 110 of the rack, the cup discharging channel module 220 is disposed along a width direction of the upper layer 110 of the rack and is close to an end portion of the cup discharging channel module, the cup separating module 230 is close to an end middle portion of the upper layer 110 of the rack, the first transferring gripper 300a connects the cup separating module 230 with the incubation system 700, and in a specific implementation, a moving path of the first transferring gripper 300a is opposite to a rotation center of the filling ring 730, and meanwhile, the first transferring gripper has an intersection portion with the dilution translation channel 431, that is, also spans across the dilution translation channel 431, where the intersection portion is a dilution reaction cup loading and unloading position, that is to say, the first transferring gripper 300a can also be used for grabbing a cup after diluting and sampling on the dilution translation channel 431, and completing solid-liquid separation of the reaction cup.

That is, dilution trolley 432 has at least seven dwell positions on dilution translation channel 431: the cuvette loading site, i.e., the site where it intersects the first transfer gripper 300a, at which time the first transfer gripper 300a may place the cuvette on the dilution trolley 432; diluting the sample filling position, namely rotating the intersection position with the sample filling needle 5221 to finish sample filling; a diluent filling station at which filling of diluent is completed; the mixing position is diluted, and the reaction cup is positioned under the stirring rod 441 at this time, so that the mixing operation can be performed; the diluted sample sampling position is the same as the diluted sample filling position, and the diluted sample is returned to the diluted sample filling position after being uniformly mixed; the dilution waste liquid sucking position, the dilution trolley 432 is positioned right below the waste liquid sucking needle, and solid-liquid separation is completed; diluting the reaction cup and losing the cup position, diluting the dolly 432 is located the intersection position with the second transportation tongs 300b, grasp the reaction cup on the dilution dolly 432 and discard through the second transportation tongs 300b, also can be the reaction cup loading position, accomplish the snatch of reaction cup and remove and lose the cup through first transportation tongs 300a equally, as shown in fig. 1, the handling operation of diluting the reaction cup is carried out to the preferred adoption first transportation tongs 300a in this application to will abandon the cup position to set up between two washing systems 800.

In combination with fig. 9 and 10, the overall working efficiency is improved by matching with the dilution system 400 in the present application, so the sample filling system mainly comprises a sample filling system base 510, and two sample filling modules 520 arranged on the sample filling system base 510, and the sample filling modules 520 are all configured with a needle washing module 530, the sample filling modules 520 in the present application comprise a sample needle base 521, a sample needle cantilever 522 arranged above the sample needle base 521, and a cantilever driving motor 523 and a cantilever lifting motor 524 for driving the sample needle cantilever 522 to rotate and lift reciprocally, respectively, the cantilever driving motor 523 and the cantilever lifting motor 524 are all fixed on the sample needle base 521 through a tensioning mechanism 525, and a vertically downward sample filling needle 5221 is arranged on the sample needle cantilever 522.

The cantilever driving motor 523 drives the sample needle cantilever 522 to rotate, so that the sample needle cantilever 522 can stay at a common sampling position, an emergency sampling position, a needle washing position, a direct sample adding position (which means that a sample is directly added into a reaction cup on the filling ring 730) and a dilution sample adding (taking) position (which is intersected with the dilution translation channel 431), and initially, the sample needle cantilever 522 is at a high position, and samples a common sample or an emergency sample in a sample supply system when staying at the common sampling position and the emergency sampling position can descend, and then rises and rotates to the direct sample adding position or rotates to the dilution sample adding (taking) position to perform sample adding operation through descending again, and sample needle washing is performed by rotating to the needle washing position every time sample adding and sampling is completed, so that sample cross contamination can be avoided, and the detection reliability is ensured.

Referring to fig. 1 and 15 to 24 with emphasis, in the present application, the reagent system 600 mainly includes a reagent chamber module 610, a reagent kit replacing module 620 and a reagent chamber base module 630, where the reagent chamber module 610 includes a reagent chamber body 611 and a reagent chamber cover 612, the reagent chamber base module 630 includes a reagent system bottom plate 631 and a reagent system top plate 632 supported above the reagent system bottom plate 631, a vertical distance between the reagent system bottom plate 631 and the reagent system top plate 632 is adapted to or slightly higher than the height of the reagent chamber module 610, the reagent chamber module 610 is fixedly arranged on the reagent system bottom plate 631, the reagent kit replacing module 620 is supported on the reagent chamber base module 630, the reagent system bottom plate 631 is fixedly connected with the upper frame layer 110, and the reagent filling module 650 is fixedly arranged on the reagent system top plate 632.

As shown in the drawing, the reagent box replacing module 620 is mainly used for realizing the on-line automatic replacement of the reagent box, so that a loading and unloading port a6120 is at least formed in the reagent bin cover 612, an exposing port 6320 for exposing the loading and unloading port a6120 is formed in the reagent system top plate 632, the reagent box replacing module 620 comprises a replacing handle unit 640 and a replacing rotary table unit 650, wherein the replacing handle unit 640 is arranged at a position corresponding to the exposing port 6320 and mainly comprises a handle opening and closing assembly 641 and a handle lifting assembly 642 for driving the handle opening and closing assembly 641 to lift, the replacing rotary table unit 650 comprises a storage plate 651 and a station driving mechanism 652, at least one reagent box replacing position 6511 and a reagent box transferring position 6512 are formed in the storage plate 651, the station driving mechanism 652 mainly comprises a storage plate driving motor 6520, and the driving motor 6520 drives the storage plate 651 to rotate between the loading and unloading stations and the avoiding stations through a synchronous belt transmission structure.

When the storage plate 651 is at the loading and unloading station, the storage plate 651 is located under the replacement gripper unit 640, at this time, the gripper opening and closing assembly 641 descends to grasp the reagent kit at the reagent kit replacement position 6511, when the storage plate 651 is at the avoidance station, the storage plate 651 deviates from the exposure opening 6320, at this time, the gripper opening and closing assembly 641 can extend into the reagent kit body 611 to grasp the right reagent kit and lift the right reagent kit into the reagent kit transfer position 6512, or to put the grasped new reagent kit onto the reagent tray in the reagent kit body 611.

In view of the opening and shielding manner of the loading and unloading port a6120, various embodiments are provided in this embodiment, and as shown in fig. 1 and 2, in the first embodiment, the loading and unloading port a6120 is configured with a cover plate a6121 corresponding to the loading and unloading port a6120, and the storage plate 651 is provided with a cover plate placing groove 6510, so that when the reagent kit is loaded and unloaded, the cover plate a6121 needs to be picked up and placed into the cover plate placing groove 6510 through the gripper opening and closing assembly 641.

In the second embodiment, the loading and unloading port a6120 is not provided with the cover plate a6121, and the storage plate 651 is directly shielded, at this time, the bottom surface of the storage plate 651 is larger than the cross section of the exposure port 6320, and in the initial state, the storage plate 651 is at the loading and unloading station and shields the exposure port 6320, that is, when the replacement gripper unit 640 does not work, the storage plate 651 is kept at the loading and unloading station all the time, and only after the storage plate 651 rotates, the loading and unloading port a6120 is exposed.

In general, the reagent bin cover 612 is further provided with a loading and unloading port B6122 and a cover plate B6123 corresponding to the loading and unloading port B6122, wherein the loading and unloading port B6122 is located outside the coverage area of the reagent system top plate 632, i.e. the loading and unloading port B6122 is not blocked by the reagent system top plate 632 all the time, and at this time, the manual loading and unloading operation of the reagent kit can be performed only after the cover plate B6123 is manually removed.

As in the third embodiment shown in fig. 19 to 23, the loading/unloading port a6120 is provided with a cover plate C6124 corresponding thereto, and the cover plate C6124 is rotatably provided on the reagent system top plate 632.

The reagent bin cover 612 is provided with a temporary storage groove 6125 at one side of the loading and unloading port A6120, the cover plate C6124 is provided with a stop part 61240 at least partially overlapped with the reagent system top plate 632 in the height direction, the cover plate C6124 can rotate relative to the reagent bin cover 612, so that the loading and unloading port A6120 is at least partially opposite to the exposing port 6320, the gripper opening and closing assembly 641 stretches into the temporary storage groove 6125 for carrying out the unloading operation of the reagent box, the cover plate C6124 can rotate at the moment to temporarily fall into the temporary storage groove 6125, or the loading and unloading port A6120 rotates to the outer side of the reagent system top plate 632 relative to the cover plate C6124, the cover plate C6124 shields the loading and unloading port A6120, and the manual loading and unloading operation of the reagent box can be carried out after the cover plate C6124 is manually rotated at the moment to fall into the temporary storage groove 6125.

Specifically, the cover plate C6124 is generally fan-shaped, the rotation center of the cover plate C6124 is close to the center of the cover plate, and a reset torsion spring 6126 is arranged between the cover plate C6124 and the reagent system top plate 632, and the reset torsion spring 6126 applies a force to the cover plate C6124 to rotate towards the side of the loading and unloading port a6120 close to the exposure port 6320, namely, when the loading and unloading port a6120 is completely located on the outer side of the cover of the reagent system top plate 632, the cover plate C6124 completely shields the loading and unloading port a6120 under the action of the reset torsion spring 6126.

When the reagent bin cover 612 rotates to enable the loading and unloading port A6120 to be close to the exposing port 6320, the cover plate C6124 rotates for a certain angle, the stop part 61240 on the cover plate C6124 is stopped by the reagent system top plate 632 and cannot rotate continuously, and the reagent bin cover 612 rotates continuously until the loading and unloading port A6120 is opposite to the exposing port 6320, so that automatic replacement operation of the reagent kit can be normally performed, which is the main maintenance state of the reagent bin cover 612, two groups of reagent acquisition windows 6128 are required to be arranged on the reagent bin cover 612, and the reagent system top plate 632 is provided with a through needle hole 6321 which can be opposite to a single group of reagent acquisition windows 6128, so that only when the reagent bin cover 612 rotates, the reagent acquisition windows 6128 are opposite to the through needle hole 6321, and reagent suction operation is facilitated.

The reagent bin cover 612 and the reagent bin body 611 are provided with a locking structure matched with each other, such as a unidirectional ratchet structure or a spring pin locking structure, the rotation of the reagent bin cover 612 can adopt a direct manual rotation mode or a motor driving mode, and various implementation results are realized, which are not described herein, and it is to be noted that in order to conveniently realize the fixation of the cover plate C6124 in the temporary storage groove 6125, a pressure spring is usually further arranged between the cover plate C6124 and the reagent system top plate 632, the pressure spring applies downward pressure to the cover plate C6124, unidirectional matched teeth are arranged between the surface of the cover plate C6124 and the temporary storage groove 6125, the two teeth are matched, and meanwhile, the cover plate C6124 can be well kept in the temporary storage groove 6125 by pressing by the pressure spring, so that the cover plate C6124 is prevented from being reset to hurt people when the manual loading and unloading operation of the reagent box is performed, and in addition, the pressure spring also ensures that the cover plate C6124 seals the loading and unloading opening A6120 more reliably.

Referring to fig. 24 with emphasis, for the structure of the loading opening a6120 and the fourth shielding embodiment, the loading opening a6120 is at least partially located under the exposing opening 6320, and partially extends out of the coverage area of the top plate 632 of the reagent system, the loading opening a6120 is configured with a cover plate D6127 adapted to the loading opening a6120, the cover plate D6127 is rotatably disposed on the top plate 632 of the reagent system, a linkage structure is provided between the cover plate D6127 and the station driving mechanism 652, and when the station driving mechanism 652 drives the storage plate 651 to rotate, the cover plate D6127 can be driven to rotate through the linkage structure so as to partially or completely expose the loading opening a 6120.

In the fourth embodiment, the loading and unloading port a6120 is relatively large, that is, a part of the loading and unloading port a6120 is located directly below the exposing port 6320, so that the automatic loading and unloading of the reagent kit can be performed, and the other part of the loading and unloading port a6120 is located outside the coverage area of the top plate 632 of the reagent system, so that the manual operation of the reagent kit can be performed. In this embodiment, the cover D6127 is configured to completely cover the exposing opening 6320, and different portions of the attaching/detaching opening a6120 are exposed by using different rotation angles. In this embodiment, the rotation of the cover plate D6127 can be performed by means of the storage plate driving motor 6520, because the motor shaft of the storage plate driving motor 6520 is vertically arranged, the cover plate D6127 is more convenient to drive, and the cover plate D6127 is driven to rotate after rotating by a certain angle, and an angle triggering linkage structure, such as a shifting piece or a gear transmission structure, which is matched with each other is arranged between the cover plate D6127 and the storage plate driving motor.

The fourth embodiment is similar to the third embodiment in that the reagent cartridge cover 612 is stationary in this embodiment, and only a set of reagent access windows 6128 are needed to meet the requirements, while the loading and unloading port A6120 is relatively large.

In addition, the present application further proposes a fifth embodiment in combination with the first embodiment and the fourth embodiment, as shown in the drawings, the loading opening a6120 is configured with a cover plate E6129 adapted to the loading opening a6120, the cover plate E6129 is rotatably supported on the reagent system top plate 632 or/and the reagent bin cover 612, and has a rotation linkage structure with the station rotation driving mechanism 652, in an initial state, the cover plate E6129 is opposite to the loading opening a6120 and forms a shielding for the loading opening a6120, and when the station rotation driving mechanism 652 drives the storage plate 651 to rotate to an avoidance station, the cover plate E6129 can be synchronously linked to rotate so as to enable the exposure opening 6320 to be communicated with the inside of the reagent bin body 611.

Specifically, the cover plate E6129 is similar to the structure in the third embodiment, and is located between the reagent system top plate 632 and the reagent chamber cover 612, and may be directly supported on the reagent chamber cover 612, or may be directly suspended on the reagent system top plate 632, and only the lower surface of the cover plate contacts the upper surface of the reagent chamber cover 612.

It should be noted that, in this embodiment, the caliber of the loading and unloading port a6120 is adapted to the size of the exposing port 6320, and is always kept right below the exposing port 6320, that is, in this embodiment, the reagent bin cover 612 is kept still, and only one group of reagent acquiring windows 6128 is provided on the reagent bin cover 612, on this basis, a rotating linkage structure is provided between the cover plate E6129 and the storage plate driving motor 6520, as described above, the storage plate driving motor 6520 may be a dual-shaft motor, and a gear engagement structure, a toggle structure, a synchronous belt transmission structure, or the like, which are matched with each other, are provided on a rotating shaft of the cover plate E6129, so that when the storage plate 651 is in the avoidance position, the cover plate E6129 just rotates away from the right range of the loading and unloading port a6120, and at this time, the gripper opening and closing assembly 641 may extend into the reagent bin to perform the loading and unloading operations of the reagent box.

In the fifth embodiment, the reagent chamber cover 612 may be provided with the mounting/dismounting port B6122 and the cover plate B6123 for manual mounting/dismounting operation of the reagent kit.

The reagent filling units 671 in the reagent filling module 670 are arranged in one-to-one correspondence with the needle holes 6321, the reagent filling units 671 are mainly used for sucking reagents and magnetic bead liquid in a reagent bin and filling the reagents into reaction cups on the filling ring 730, and the reagent filling units 671 comprise reagent filling needles and reagent needle driving mechanisms for driving the reagent filling needles to translate and lift.

The reagent storehouse body 611 is internally provided with a reagent disc horizontally arranged and a reagent disc driving and rotating mechanism for driving the reagent disc to rotate, the reagent disc is provided with reagent box storage tanks uniformly distributed along the circumferential direction of the reagent disc, the bottom of the reagent disc is provided with a reagent mixing component 660 corresponding to each reagent box storage tank, as shown in fig. 26, the reagent mixing component 660 mainly comprises a mixing installation seat 661 and a mixing shaft 662 vertically arranged on the mixing installation seat 661 in a sliding manner, and a supporting spring 663 is arranged between the mixing shaft 662 and the mixing installation seat 661.

Specifically, the mixing mount 661 is fixedly arranged on the reagent disk, a vertically arranged mixing shaft sleeve 664 is arranged in the mixing mount 661, the mixing shaft sleeve 664 is rotatably supported in the mixing mount 661 through a bearing as shown in the figure, and a mixing pinion 665 is sleeved at the lower end of the mixing shaft sleeve.

The mixing shaft sleeve 664 is of a hollow structure, the mixing shaft 662 is vertically arranged in the mixing shaft sleeve 664, a mixing claw 6620 which is mutually adapted to the bottom structure of the magnetic bead bottle in the kit is arranged at the top of the mixing shaft 662, a necking section 6621 is arranged at the lower part of the mixing shaft 662, a limiting boss 6640 which extends inwards is arranged in the mixing shaft sleeve 664, a limiting screw 6622 is connected after the necking section 6621 passes through the limiting boss 6640, and the mixing shaft 662 can only lift and slide in a limited range under the limitation of the upper part of the mixing shaft 662 and the limiting screw 6622.

Meanwhile, the supporting spring 663 is sleeved on the necking section 6621 at the upper part of the limiting boss 6640, in an initial state, the mixing shaft 662 is in an extending state under the action of the supporting spring 663, at the moment, the lower surface of the mixing claw 6620 is not in contact with the upper surface of the mixing shaft sleeve 664, when the mixing claw 6620 is subjected to pressure sinking and is in contact with the upper surface of the mixing shaft sleeve 664, the mixing claw 6620 can easily rotate along with the mixing shaft sleeve 664, even if the reagent mixing assembly 660 is initially placed in a reagent box, a magnetic bead bottle on the reagent mixing assembly is not clamped with the mixing claw 6620, after the mixing shaft 662 rotates, the mixing shaft 662 can easily bounce under the action of the supporting spring 663 to be clamped with the magnetic bead bottle, namely the structure can better enable the mixing claw 6620 to be clamped with the bottom of the magnetic bead bottle placed in the reagent box, and the reagent mixing requirement is met.

As shown, the washing system 800 and the independent mixing mechanism 130 in the present application are two, the sample filling system includes two sample filling modules 520, the reagent filling module 650 includes three reagent filling units 671 parallel to and opposite to the filling ring 730, and one reagent needle translation path in one reagent filling unit 671 is disposed along the radial direction of the filling ring 730, and the other two reagent filling units 671 are symmetrically disposed on two sides of the reagent filling unit 671. On this basis, two washing systems 800 are respectively disposed at both sides of the first transfer grip 300a in the implementation, and since the cuvette loading system 200 is mainly a hopper structure, it is usually supported relatively high by a stand, and thus the part of the washing system 800 near the cuvette loading system 200 is disposed under it.

In a specific arrangement, as shown in fig. 1, the rotation center of the cup separating disc in the cup separating module 230, the rotation center of the filling ring 730 and the rotation center of the reagent disc in the reagent system 600 are located on the same vertical plane, and the cup separating module 230 and the reagent system 600 are respectively located at two sides of the incubation system 700, so that the diameters of the three are generally increased in sequence, and according to the layout mode, the space utilization efficiency can be further improved, and the overall layout is more compact.

Referring to fig. 27 with emphasis, a washing system 800 of the present application mainly includes a washing base 810, and a waste liquid needle lifting base 820 disposed above the washing base 810, wherein the washing base 810 is provided with a washing disc disposed in a rotatable manner, the washing disc is provided with washing reaction cup placement holes, and magnet groups distributed on the outer side of the circumference of the washing disc, as shown in the figure, the washing reaction cup placement holes are distributed in a circumferential array, a gripping opening 812 is disposed on one side of the washing base 810, a guiding structure is disposed between the waste liquid needle lifting base 820 and the washing base 810, a screw motor for driving the waste liquid needle lifting base 820 to lift is disposed on the washing base 810, and a waste liquid needle 821 disposed vertically is disposed on the waste liquid needle lifting base 820.

On the other hand, in this embodiment, at least N-order magnet groups are provided, each order magnet group includes at least six magnet blocks 813, the distribution angle of the adjacent magnet blocks 813 is adapted to the distribution angle of the placing holes of the washing reaction cup, where N is an integer greater than or equal to 2, along the rotation direction of the washing turntable, the top and bottom of the magnet blocks 813 in the first to N-1 th orders are flush and identical, the heights of the magnet blocks 813 are all H1, at least an adsorption magnet group, a pull-down magnet group and a pull-down holding magnet group are sequentially provided in the nth order along the rotation direction of the washing turntable, wherein the heights of the tops of the magnet blocks 813 in the adsorption magnet group and the pull-down magnet group are sequentially reduced, the heights of the tops of the magnet blocks 813 in the pull-down holding magnet group are identical, and are flush with or lower than the top surfaces of the adjacent magnet blocks in the pull-down magnet group, so that the magnetic bead adsorption duration can be prolonged, and the accuracy of the detection result can be ensured.

Referring to the compact high-efficiency magnetic particle immunoassay analyzer shown in fig. 1 to 27, a sample rack loaded with a sample bottle is initially sent into a conveying channel R, and then a sampling hand grip or an emergency positioning hand grip in the conveying channel R is used for positioning the sample rack in a corresponding channel, so that accurate sampling is matched with detection, and sampling error rate is reduced.

Test procedure for one-step method: after the sample filling system draws the sample, the sample is directly filled into the dilution trolley 432 or a reaction cup on the filling ring 730, for example, after the sample is filled into the reaction cup on the dilution trolley 432, the sample is diluted and uniformly mixed, then is sucked and finally filled into the reaction cup on the filling ring 730, and is filled with reagents such as magnetic particles and the like through the reagent filling unit 671, and is then sent to the independent uniformly mixing mechanism 130 for independent uniform mixing operation, and then is sent to the incubation plate 720 for constant-temperature incubation, and then is sent to the washing system 800 for washing and substrate filling operation, and then is sent back to the incubation plate 720 for detection in the detection system 900 after incubation is completed, and the whole process takes the incubation plate 720 and the filling ring 730 as intermediate media, and the operation requirement of corresponding modules is met through rotation, so that the detection period can be greatly shortened, and the detection efficiency is improved.

Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and that many similar changes can be made by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.

Claims

1. The utility model provides a high-efficient magnetic particle immunity analysis appearance of compact, includes frame upper strata (110), be close to middle part position on frame upper strata (110) and be equipped with incubation system (700), its characterized in that: the incubation system (700) comprises an incubation module (720) and a filling ring (730) rotatably arranged on the circumferential outer side of the incubation module (720), wherein filling ring (730) is provided with filling reaction cup placement holes distributed in a circumferential array;

sample filling system, dilution system (400), reaction cup loading system (200), reagent system (600), detecting system (900) and at least one washing system (800) and independent mixing mechanism (130) that are distributed around incubating system (700) are arranged on frame upper strata (110), wherein reagent system (600) are including setting up in reagent filling module (670) at its top, washing system (800) are including washing seat (810) and be located waste liquid needle lift seat (820) of this washing seat (810) top, waste liquid needle lift seat (820) can go up and down in order to carry out the waste liquid suction relative washing seat (810), be equipped with the transfer system that is used for carrying out the reaction cup interaction between reaction cup loading system (200), detecting system (900), washing system (800) and independent mixing mechanism (130) and incubating system (700).

2. The compact, high performance magnetic particle immunoassay instrument of claim 1, wherein: the transfer system comprises a first transfer gripper (300 a) arranged between the cuvette loading system (200) and the incubation system (700);

the sample filling system is close to one side of the upper layer (110) of the rack, the dilution system (400) comprises a dilution channel module (410) and a dilution mixing module (420) which are distributed at an included angle, the dilution channel module (410) comprises a dilution trolley translation assembly (430) and a dilution needle group lifting assembly (460), and the dilution trolley translation assembly (430) comprises a dilution translation channel (431) and a dilution trolley (432) which is in sliding fit with the dilution translation channel (431);

the first transfer gripper (300 a) is opposite to the rotation center of the filling ring (730) in a moving path, and has an intersection part with the dilution translation channel (431), wherein the intersection part is a dilution reaction cup loading and unloading position.

3. The compact high-efficiency magnetic particle immunoassay instrument of claim 2, wherein: the dilution mixing module (420) comprises a mixing frame (421) and a stirring assembly (440) arranged on the mixing frame (421), the stirring assembly (440) comprises a stirring rod (441) and a dilution mixing lifting assembly (442) and a dilution mixing translation assembly (443) which are respectively used for driving the stirring rod (441) to lift and translate, and a stirring motor (444) for driving the stirring rod (441) to rotate, a translation path of the dilution trolley (432) and a translation path of the stirring rod (441) are provided with an intersection part, and the translation path of the stirring rod (441) is parallel to one side close to a sample filling system.

4. A compact, high performance magnetic particle immunoassay according to claim 2 or 3, wherein: the reaction cup loading system (200) comprises a cup discharging module (210), a cup discharging channel module (220) and a cup separating module (230), wherein the cup discharging module (210) is close to one corner of the upper layer (110) of the machine frame, the cup discharging channel module (220) is arranged along the width direction of the upper layer (110) of the machine frame and is close to one end part of the cup discharging channel module, and the cup separating module (230) is close to the middle part of one end of the upper layer (110) of the machine frame.

5. The compact, high performance magnetic particle immunoassay instrument of claim 1, wherein: the washing system (800), the detection system (900), the independent mixing mechanism (130) and the incubation system (700) are respectively provided with a second transferring gripper (300 b), a third transferring gripper (300 c) and a fourth transferring gripper (300 d), and the moving paths of the transferring grippers are all arranged along the radial direction of the filling ring (730).

6. The compact high performance magnetic particle immunoassay analyzer of any of claims 1 to 3 or 5, wherein: reagent system (600) include reagent storehouse module (610), reagent box change module (620) and reagent storehouse base module (630), wherein reagent storehouse module (610) are including reagent storehouse body (611) and reagent storehouse lid (612), reagent storehouse base module (630) include reagent system bottom plate (631) and support in reagent system roof (632) of this reagent system bottom plate (631) top, reagent storehouse module (610) set firmly on reagent system bottom plate (631), reagent box change module (620) support on reagent storehouse base module (630), reagent system bottom plate (631) and frame upper strata (110) fixed connection, reagent filling module (670) set firmly on reagent system roof (632).

7. The compact, high performance magnetic particle immunoassay instrument of claim 6, wherein: at least a loading and unloading port A (6120) is formed in the reagent bin cover (612), and an exposure port (6320) is formed in the reagent system top plate (632);

the reagent box replacement module (620) comprises a replacement handle unit (640) and a replacement rotary table unit (650), wherein the replacement rotary table unit (650) comprises a storage plate (651) and a station rotation driving mechanism (652), the station rotation driving mechanism (652) is used for driving the storage plate (651) to rotate between a loading and unloading station and an avoidance station, when the storage plate (651) is located at the loading and unloading station, the storage plate (651) is located under the replacement handle unit (640), and when the storage plate (651) is located at the avoidance station, the storage plate (651) deviates from the exposure port (6320).

8. The compact, high performance magnetic particle immunoassay instrument of claim 7, wherein: the loading and unloading port A (6120) is provided with a cover plate C (6124) which is matched with the loading and unloading port A, and the cover plate C (6124) is rotatably arranged on a reagent system top plate (632);

the reagent bin cover (612) is provided with a temporary storage groove (6125) at one side of the loading and unloading port A (6120), the cover plate C (6124) is provided with a stop part (61240) which is at least partially overlapped with the reagent system top plate (632) in the height direction, the cover plate C (6124) can rotate relative to the reagent bin cover (612) so that the loading and unloading port A (6120) is at least partially opposite to the exposing port (6320), the cover plate C (6124) rotates to fall into the temporary storage groove (6125), or the loading and unloading port A (6120) rotates to the outer side of the reagent system top plate (632) relative to the cover plate C (6124), and the cover plate C (6124) shields the loading and unloading port A (6120).

9. The compact, high performance magnetic particle immunoassay instrument of claim 7, wherein: the loading and unloading port A (6120) is provided with a cover plate E (6129) which is matched with the loading and unloading port A (6120), the cover plate E (6129) is rotatably supported on a reagent system top plate (632) or/and a reagent bin cover (612), a rotary linkage structure is arranged between the cover plate E (6129) and the station driving mechanism (652), the cover plate E (6129) is opposite to the loading and unloading port A (6120) and shields the loading and unloading port A (6120) in an initial state, and when the station driving mechanism (652) drives the storage plate (651) to rotate to an avoidance station, the cover plate E (6129) can be synchronously linked to rotate so that the exposure port (6320) is communicated with the inside of the reagent bin body (611).

10. The compact high performance magnetic particle immunoassay analyzer of any of claims 1 to 3 or 5, wherein: the washing system (800) and the independent mixing mechanism (130) are two, the sample filling system comprises two sample filling modules (520), the reagent filling module (670) comprises three reagent filling units (671) which are parallel and are opposite to the filling ring (730), and a reagent needle translation path in one reagent filling unit (671) is arranged along the radial direction of the filling ring (730).

11. A compact, high performance magnetic particle immunoassay according to claim 2 or 3, wherein: the number of the washing systems (800) is two, and the two washing systems (800) are respectively positioned at two sides of the first transfer grip (300 a).

12. The compact, high performance magnetic particle immunoassay instrument of claim 4, wherein: the rotation center of the cup separating disc in the cup separating module (230), the rotation center of the filling ring (730) and the rotation center of the reagent disc in the reagent system (600) are arranged on the same vertical plane, and the cup separating module (230) and the reagent system (600) are respectively positioned on two sides of the incubation system (700).