CN115813801A - A kind of ascorbic acid transdermal absorption composition and its application - Google Patents

Abstract

The present application provides an ascorbic acid transdermal absorption composition, which includes ascorbic acid and amino acid-based polar oils, and further includes p-coumaric acid derivatives and tocopherol. The ascorbic acid transdermal absorption combination of the present application improves the stability of ascorbic acid and the transdermal efficiency of ascorbic acid, and provides consumers with a good and stable ascorbic acid product and technology with good skin feeling.

Description

A kind of ascorbic acid transdermal absorption composition and its application

technical field

The application belongs to the technical field of cosmetics, and in particular relates to an ascorbic acid transdermal absorption composition and its application. The composition is a stable cosmetic composition capable of promoting ascorbic acid absorption.

Background technique

Vitamin C, commonly known as ascorbic acid, has a chemical name of 2,3,5,6-tetrahydroxy-2-hexene-4-lactone, because the two adjacent carbon-carbon double bonds at the 2nd and 3rd positions in the molecule are simultaneously It has a hydroxyl group, that is, an enol structure. It is chemically unstable and has strong reductivity. It is easy to dissociate protons and form dehydroascorbic acid. Further hydrolysis can form diketogulonic acid, thus losing physiological active. Studies have pointed out that ascorbic acid is very sensitive to light, oxygen, water, temperature, pH, metal ions, etc., especially in aqueous solution, it is easy to be hydrolyzed and inactivated, and it is accompanied by discoloration, such as yellowing or even browning. (Sheraz M A, Khan M F, Ahmed S, et al. Stability and Stabilization of Ascorbic Acid. 2015.)

In 2005, SkinCeuticals of the United States applied for a patent for a stable ascorbic acid composition (US2005154054A1), which stabilized a 15% ascorbic acid aqueous solution by using up to 20% of alcohol ether and about 10% of alkyl glycol. Investigated the thermal stability of 4 weeks, the retention rate of ascorbic acid was still as high as 82% of the initial value after 4 weeks. Although the addition of a large amount of alcohol ether solvent can better maintain the stability of ascorbic acid, it will bring a very sticky skin feeling and strong stimulation to the user. If reduce the addition amount of alcohol ether solvent, be difficult to guarantee the stability of ascorbic acid again.

In recent years, with the development of cosmetic packaging technology, ascorbic acid and solution separation products have appeared on the market, that is, ascorbic acid is packaged separately in the form of powder, and mixed with the solution before use. This method can well maintain the long-term stability of ascorbic acid , but its shortcomings are also obvious. The requirements for packaging materials are high, which greatly increases the cost of the product, and it is inconvenient to use.

Contents of the invention

To solve the above-mentioned problems in the prior art, the present application provides a composition containing ascorbic acid, the stability of ascorbic acid is improved by adding polar oil derived from amino acid, and the composition has the effect of promoting the transdermal absorption of ascorbic acid. The composition of the present application may include tocopherol and/or p-coumaric acid derivatives to further improve the stability of ascorbic acid without adding a large amount of alcohol ether solvent to dissolve the p-coumaric acid derivatives, and the skin feels refreshing, specifically , this application involves the following aspects:

1. An ascorbic acid transdermal absorption composition, wherein the composition comprises ascorbic acid and polar oil derived from amino acid.

2. The composition according to item 1, wherein the polar oil based on amino acid derivatization includes isopropyl N-lauroyl glutamate, phytosterol/octyldodecyl lauroyl glutamate, and One or more of phytosterol/behenyl alcohol/octyldodecanol lauroyl glutamate.

3. The composition according to item 1 or 2, wherein, in terms of parts by mass, the composition includes 3-25 parts of ascorbic acid and 2-20 parts of amino acid-derived polar oil.

4. The composition according to any one of items 1-3, wherein the composition also includes a p-coumaric acid derivative, preferably, in parts by mass, the p-coumaric acid derivative The content is 0.1-3 parts.

5. The composition according to item 4, wherein the p-coumaric acid derivative comprises one or both of ferulic acid and caffeic acid.

6. The composition according to any one of items 1-5, wherein the composition further comprises tocopherol, preferably, the content of the tocopherol is 0.1-5 parts by mass.

7. The composition according to any one of items 1-6, wherein the composition further comprises an emulsifier, preferably, the content of the emulsifier is 0.5-5 parts by mass.

8. The composition according to item 7, wherein the emulsifier comprises ceteareth-25, ceteareth-20, polyacrylate-1, laureth-4 one or more of them.

9. The composition according to any one of items 1-8, wherein the composition further comprises cosmetically acceptable excipients and/or functional ingredients.

10. Use of the composition described in any one of items 1-9 in improving the stability of ascorbic acid and/or promoting the transdermal absorption of ascorbic acid.

The ascorbic acid transdermal absorption composition of the present application improves the stability of ascorbic acid and the transdermal efficiency of ascorbic acid, avoids the sticky feeling of use caused by using a large amount of alcohol ether as a solvent, and provides consumers with a skin feeling Good and stable ascorbic acid products and technology.

Detailed ways

The present application will be further described below in conjunction with the examples. It should be understood that the examples are only used to further illustrate and explain the present application, and are not intended to limit the present application.

Unless otherwise defined, technical and scientific terms in this specification have the same meaning as commonly understood by a person skilled in the art. Although methods and materials similar or identical to those described herein can be employed in experiments or practical applications, the materials and methods are described herein below. In case of conflict, the present specification, including definitions, will control and the materials, methods, and examples are presented for purposes of illustration only and not limitation. The present application will be further described below in conjunction with specific examples, but they are not used to limit the scope of the present application.

The present application provides an ascorbic acid transdermal absorption composition, which comprises ascorbic acid and polar oil derived from amino acid.

The amino acid-based polar oils include isopropyl N-lauroyl glutamate, phytosterol/octyldodecyl lauroyl glutamate, and phytosterol/behenyl/octyldodecyl lauryl One or two or more of acylglutamic acid esters.

In a specific embodiment, the amino acid-based polar oil is isopropyl N-lauroyl glutamate.

In a specific embodiment, in terms of parts by mass, the composition includes 3-25 parts of ascorbic acid, such as 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, etc., preferably 10-20 parts; 2-20 parts based on amino acid-derived polar oils, such as 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, etc., preferably 2-15 parts, more preferably 3-10 parts.

In a specific embodiment, the composition further includes p-coumaric acid derivatives.

In the present application, p-coumaric acid derivatives include one or both of ferulic acid and caffeic acid.

In a specific embodiment, the p-coumaric acid derivative is ferulic acid.

In a specific embodiment, the p-coumaric acid derivative is caffeic acid.

In a specific embodiment, in terms of parts by mass, the composition further includes 0.1-3 parts of p-coumaric acid derivatives, such as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts, 2.1 parts, 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, 2.8 parts, 2.9 parts, 3 parts, etc., preferably 0.5-1 parts.

In a specific embodiment, said composition further comprises tocopherol.

Among them, tocopherol is the hydrolysis product of vitamin E, and the natural tocopherol is D-tocopherol (dextrorotary), which has 8 isomers such as α, β, γ, and δ, among which α- Tocopherol is the most active. The tocopherol mixed concentrate used as an antioxidant is a mixture of various isomers of natural tocopherol. It is widely used in whole milk powder, butter or margarine, meat products, processed aquatic products, dehydrated vegetables, juice drinks, frozen foods and convenience foods, especially tocopherol as baby food, curative food, fortified food, etc. Antioxidants and nutritional fortifiers are more important.

In a specific embodiment, in terms of parts by mass, the composition further includes 0.1-5 parts of tocopherol, such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part , 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.5, 3, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc., preferably 0.5-3 parts.

In a specific embodiment, in the composition, the content of ascorbic acid is 3wt%-25wt%, such as 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt% %, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt%, 20wt%, 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, etc., preferably 10wt%-20wt%.

In a specific embodiment, in the composition, the content of polar oil derived from amino acid is 2wt%-20wt%, such as 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt% %, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt%, 20wt%, etc., preferably 2wt%-15wt%, More preferably 3wt%-10wt%.

In a specific embodiment, in the composition, the content of p-coumaric acid derivatives is 0.1wt%-3wt%, such as 0.1wt%, 0.2wt%, 0.3wt%, 0.4wt%, 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt% , 1.8wt%, 1.9wt%, 2wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3wt% etc., preferably 0.5wt%-1wt%;

In a specific embodiment, in the composition, the content of tocopherol is 0.1wt%-5wt%, such as 0.1wt%, 0.2wt%, 0.3wt%, 0.4wt%, 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt% , 1.9wt%, 2wt%, 2.5wt%, 3wt%, 3.5wt%, 4wt%, 4.5wt%, 5wt%, etc., preferably 0.5wt%-3wt%.

The composition of the present application may further include an emulsifier, wherein the emulsifier may be an emulsifier commonly used in the field of cosmetics, and those skilled in the art may make routine selections in the prior art.

In a specific embodiment, the emulsifier includes one of ceteareth-25, ceteareth-20, polyacrylate-1, laureth-4 or Two or more.

In a specific embodiment, in the composition, the emulsifier is 0.5-5 parts by mass, for example, 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts , 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.

In a specific embodiment, in the composition, the content of the emulsifier is 0.5wt%-5wt%, such as 0.5wt%, 1wt%, 1.5wt%, 2wt%, 2.5wt%, 3wt%, 3.5wt%, 4wt%, 4.5wt%, 5wt%, etc.

In a specific embodiment, the composition includes 3wt%-25wt% ascorbic acid, 0.1wt%-5wt% tocopherol, 0.1wt%-3wt% p-coumaric acid derivatives, 2wt%-20wt% amino acid derivatives Polar oil and 0.5wt%-5wt% emulsifier.

In a specific embodiment, the composition includes 10wt%-20wt% ascorbic acid, 0.5wt%-3wt% tocopherol, 0.5wt%-1wt% p-coumaric acid derivatives, 2wt%-15wt% amino acid derivatives Polar oil and 0.5wt%-5wt% emulsifier.

In a specific embodiment, the composition includes 5wt%-20wt% ascorbic acid, 0.1wt%-5wt% tocopherol, 0.1wt%-2wt% p-coumaric acid derivatives, 3wt%-15wt% Polar oil, 0.5wt%-5wt% emulsifier and 0.01wt%-5wt% glycerin.

In a specific embodiment, the collection composition is composed of ascorbic acid, tocopherol, p-coumaric acid derivatives, polar oils based on amino acid derivatization, and water.

In a specific embodiment, the ascorbic acid transdermal absorption composition consists of 5wt%-20wt% ascorbic acid, 0.1wt%-5wt% tocopherol, 0.1wt%-2wt% p-coumaric acid derivatives, 3wt%-20wt% % based on amino acid derived polar oils and water composition.

In a specific embodiment, the composition consists of ascorbic acid, tocopherol, p-coumaric acid derivatives, amino acid-based polar oils, emulsifiers and water.

In a specific embodiment, the composition is composed of 5wt%-20wt% ascorbic acid, 0.1wt%-5wt% tocopherol, 0.1wt%-2wt% p-coumaric acid derivatives, 3wt%-20wt% amino acid-based It consists of polar oil, 0.5wt%-5wt% emulsifier and water.

Further, the composition also includes cosmetically acceptable excipients and/or functional ingredients.

For auxiliary materials, including solvents, thickeners, preservatives, acid-base regulators, essences, etc. commonly used in cosmetics, for example, the solvents can be water, alcohol, and oily ester solvents acceptable in the field of cosmetics, and the solvents may not include Ethylene glycol ethers, alkyl glycols; The thickener can be a thickener commonly used in the field of cosmetics, such as cellulose, xanthan gum, guar gum, poloxamer, etc.; for preservatives, it can be Acceptable preservatives in the field of cosmetics, such as alcohol preservatives, phenolic preservatives, Nepal gold preservatives, organic acid preservatives, quaternary ammonium preservatives, etc.; acid-base regulators can be acceptable acids in the field of cosmetics , alkali, inorganic salt, etc.; for essence, it can be acceptable animal essence, plant essence, synthetic essence, etc. in the field of cosmetics.

For functional ingredients, it includes whitening ingredients, moisturizing ingredients, anti-wrinkle ingredients, anti-aging ingredients, oil control and acne ingredients, and repairing ingredients commonly used in cosmetics. For example, commonly used whitening ingredients in the field of cosmetics include but are not limited to resorcinol compounds, fruit acids and their derivatives, vitamin C and its derivatives, azelaic acid, arbutin and its derivatives, kojic acid and its derivatives substances, tranexamic acid, pantothenic acid derivatives, biological whitening preparations, natural animal and plant extracts, etc.; commonly used moisturizing ingredients in the field of cosmetics include but are not limited to hyaluronic acid, vitamin B5, hydroxyethyl urea, betaine, lecithin, Polyols, amino acids, xylitol, etc.; anti-wrinkle ingredients commonly used in the cosmetic field include but not limited to vitamin C, A alcohol, Bosein, peptides, etc.; anti-aging ingredients commonly used in the cosmetic field include but not limited to retinol , Boseine, fullerene, etc.; oil control and acne-removing ingredients commonly used in the field of cosmetics include but not limited to salicylic acid, fruit acid, niacinamide, witch hazel, etc.; repairing ingredients commonly used in the field of cosmetics include but not limited to ceramide, Ectoine, allantoin, centella asiatica, chamomile, etc.

In a specific embodiment of the present application, the composition further comprises glycerin as a moisturizing ingredient.

The present application also provides the use of the above-mentioned composition in improving the stability of ascorbic acid and/or promoting the transdermal absorption of ascorbic acid.

Example

The experimental methods used in the following examples are conventional methods unless otherwise specified.

Example 1

Weigh 15g L-ascorbic acid, 0.5g polyacrylate-1, add 77.5g water and stir evenly, heat up to 60°C as phase A; weigh 1g tocopherol, 0.5g ferulic acid, 3.5g N-lauroyl sarcosine Isopropyl ester and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Example 2

Weigh 15g L-ascorbic acid, 0.5g polyacrylate-1, add 76g water and stir evenly, heat up to 60°C as phase A; weigh 1g tocopherol, 2.0g ferulic acid, 3.5g N-lauroyl sarcosine iso Propyl ester and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Example 3

Weigh 15g L-ascorbic acid, 0.5g polyacrylate-1, add 71g water and stir evenly, heat up to 60°C as phase A; weigh 1g tocopherol, 2.0g ferulic acid, 10g N-lauroyl sarcosine isopropyl Esters and 2g ceteareth-25 were heated to 60°C and melted as phase B, B was added to A homogeneously at 3000 rpm for 3 minutes, and the ascorbic acid composition was obtained after cooling down.

Example 4

Weigh 15g L-ascorbic acid, 0.5g polyacrylate-1, add 78g water and stir evenly, heat up to 60°C as phase A; weigh 0.5g tocopherol, 0.5g ferulic acid, 3.5g N-lauroyl sarcosine Isopropyl ester and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Example 5

Weigh 5g L-ascorbic acid, 0.5g polyacrylate-1, add 87.5g water and stir evenly, heat up to 60°C as phase A; weigh 1g tocopherol, 0.5g ferulic acid, 3.5g N-lauroyl sarcosine Isopropyl ester and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered.

Example 6

Weigh 20g L-ascorbic acid, 0.5g polyacrylate-1, add 72.5g water and stir evenly, heat up to 60°C as phase A; weigh 1g tocopherol, 0.5g ferulic acid, 3.5g N-lauroyl sarcosine Isopropyl ester and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Example 7

Weigh 15g L-ascorbic acid, 0.5g polyacrylate-1, add 76.5g water and stir evenly, heat up to 60°C as phase A; weigh 2g tocopherol, 0.5g ferulic acid, 3.5g N-lauroyl sarcosine Isopropyl ester and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered.

Example 8

Weigh 15g L-ascorbic acid, 0.5g polyacrylate-1, add 77.5g water and stir evenly, raise the temperature to 60°C as phase A; weigh 1g tocopherol, 0.5g ferulic acid, 3.5g phytosterol/octyldodecane Alcohol lauroyl glutamate and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Example 9

Weigh 15g of L-ascorbic acid, 3g of glycerin, 0.5g of polyacrylate-1, add 74.5g of water and stir evenly, raise the temperature to 60°C as phase A; weigh 1g of tocopherol, 0.5g of ferulic acid, 3.5g of N-lauroyl Isopropyl sarcosinate and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Example 10

Weigh 15g of L-ascorbic acid, add it to 77.5g of water and stir evenly, heat up to 60°C as phase A; weigh 1g of tocopherol, 0.5g of ferulic acid, 3.5g of N-lauroyl sarcosinate isopropyl ester, 2.5g of cetyl wax Steareth-25 was heated to 60°C and melted as phase B, B was added to A homogeneously at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Example 11

Weigh 15g of L-ascorbic acid, 0.5g of polyacrylate-1, add 77.5g of water and stir evenly, raise the temperature to 60°C as phase A; weigh 1g of tocopherol, 0.5g of caffeic acid, 3.5g of N-lauroyl sarcosine iso Propyl ester and 2g of ceteareth-25 were heated to 60°C and melted as phase B, and B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Example 12

Weigh 15g L-ascorbic acid, add 80g water and stir evenly, heat up to 60°C as phase A; weigh 1g tocopherol, 0.5g ferulic acid, 3.5g N-lauroyl sarcosine isopropyl ester and heat to 60°C to melt as In phase B, B was added to A to homogenize at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Comparative example 1

Weigh 15g of L-ascorbic acid, 3g of glycerin, 0.5g of polyacrylate-1, add 77.5g of water and stir evenly, raise the temperature to 60°C as phase A; weigh 1g of tocopherol, 0.5g of ferulic acid, 3.5g of propylene glycol ether, 2g Ceteareth-25 was heated to 60°C and melted as phase B, B was added to A homogeneously at 3000 rpm for 3 minutes, and the temperature was lowered to obtain the ascorbic acid composition.

Comparative example 2

Weigh 15g L-ascorbic acid, 0.5g polyacrylate-1, add 80g water and stir evenly, heat up to 60°C as phase A; weigh 1g tocopherol, 0.5g ferulic acid, 1g N-lauroyl sarcosine isopropyl Esters and 2g ceteareth-25 were heated to 60°C and melted as phase B, B was added to A homogeneously at 3000 rpm for 3 minutes, and the ascorbic acid composition was obtained after cooling down.

Comparative example 3

Weigh 15g of L-ascorbic acid and add it to 85g of water, stir evenly, raise the temperature to 60°C, and lower the temperature to obtain the ascorbic acid composition.

The concrete conditions of above-mentioned embodiment and comparative example are as shown in table 1.

Table 1

Test case

Test Example 1 Stability Test

The samples prepared in the above examples and comparative examples were subjected to a stability test. Specifically, the ascorbic acid compositions prepared in the above-mentioned examples and comparative examples were divided into colorless and transparent PET vials, and placed in a Binder oven at 45°C±2°C without light protection for 28 days. High temperature stability, after reaching the set investigation time, take out the emulsion from the oven and place it at room temperature and return to room temperature, use HPLC to quantify the content of ascorbic acid, divide the measured ascorbic acid content by the initial ascorbic acid content, and obtain the retention ratio of ascorbic acid. The results are shown in Table 2.

Table 2

retention ratio Example 1 92.50% Example 2 93.10% Example 3 92.70% Example 4 90.30% Example 5 91.90% Example 6 92.60% Example 7 93.40% Example 8 91.90% Example 9 92.55% Example 10 92.47% Example 11 92.52% Example 12 88.6% (oil-water phase) Comparative example 1 84.10% Comparative example 2 80.5% (ferulic acid has precipitated) Comparative example 3 42%

As can be seen from Table 2, the amino acid derived polar oil used in the examples and the propylene glycol ether used in Comparative Example 1 can dissolve p-coumaric acid derivatives such as ferulic acid, but compared with Comparative Example 1 , the amino acid-derived polar oil used in the examples can improve the stability of ascorbic acid. And under the same dosage, the alcohol ether solvent of Comparative Example 1 is less stable to ascorbic acid than the amino acid-derived polar oil used in the examples.

Test example 2 in vitro transdermal absorption test

The ascorbic acid composition of the present application is tested for in vitro transdermal absorption by the Franz diffusion cell method. Pig skin is used as a carrier, which is fixed between the supply chamber and the receiving chamber of the Franz diffusion cell, and the diffusion cell is fixed on the transdermal absorption diffusion cell. In the instrument, under the condition of turning on the magnetic stirring bar and the constant temperature water bath, the ascorbic acid composition samples prepared in the examples and the comparative examples were added to the skin surface in the chamber to carry out the transdermal test. As the receiving solution, an aqueous solution containing 20% polyethylene glycol (PEG)+PBS was selected, and the transdermal amounts of ascorbic acid and ferulic acid were measured at 2h, 4h, 8h, and 24h, respectively. The formula for calculating the cumulative transdermal volume Q is: Q=[Cn x V+∑Ci x V0]/S(i=1...n-1), where Q is the cumulative transdermal volume, S is the effective diffusion area, and V is the receiving chamber V0 is the volume of each sampling, Ci is the drug concentration in the receiving solution from the first sampling to the last sampling, and Cn is the sample concentration measured at the nth sampling point. The cumulative transdermal amount of ascorbic acid in the composition changes with time as shown in Table 3.

The cumulative transdermal amount of ascorbic acid in different time in table 3 ascorbic acid composition

As can be seen from Table 3, compared with Example 1-4, 7-12 and Comparative Example 3, under the same situation of the ascorbic acid addition amount in the composition, the embodiment has a higher transdermal absorption of ascorbic acid, indicating that this The applied composition has the effect of significantly improving the transdermal absorption of ascorbic acid. Compared with Examples 1 and 8 and Comparative Example 1, the amino acid-derived polar oil can significantly increase the transdermal absorption of ascorbic acid in the ascorbic acid composition compared with propylene glycol ether.

Claims (10)

1. An ascorbic acid transdermal absorption composition, characterized in that, the composition comprises ascorbic acid and polar oil based on amino acid derivatization. 2. Composition according to claim 1, is characterized in that, described based on the polar oil derived from amino acid comprises N-lauroyl glutamate isopropyl ester, phytosterol/octyldodecanol lauroyl glutamate Esters, and one or more of phytosterol/behenyl alcohol/octyldodecanol lauroyl glutamate. 3. The composition according to claim 1 or 2, characterized in that, in parts by mass, the composition comprises 3-25 parts of ascorbic acid and 2-20 parts of polar oil derived from amino acid. 4. according to the composition described in any one in claim 1-3, it is characterized in that, described composition also comprises p-coumaric acid derivative, preferably, by mass parts, described p-coumaric acid The content of the derivative is 0.1-3 parts. 5. The composition according to claim 4, wherein the p-coumaric acid derivatives comprise one or both of ferulic acid and caffeic acid. 6. The composition according to any one of claims 1-5, characterized in that, the composition also includes tocopherol, preferably, in parts by mass, the content of the tocopherol is 0.1-5 share. 7. The composition according to any one of claims 1-6, characterized in that, the composition also includes an emulsifier, preferably, in parts by mass, the content of the emulsifier is 0.5-5 share. 8. The composition according to claim 7, wherein the emulsifier comprises ceteareth-25, ceteareth-20, polyacrylate-1, laureth One or more of ether-4. 9. The composition according to any one of claims 1-8, characterized in that, the composition further comprises cosmetically acceptable excipients and/or functional ingredients. 10. Use of the composition according to any one of claims 1-9 in improving the stability of ascorbic acid and/or promoting the transdermal absorption of ascorbic acid.