CN115568472B

CN115568472B - Insecticidal composition containing benzpyrimoxan and dicyclanil ester and application thereof

Info

Publication number: CN115568472B
Application number: CN202211407468.3A
Authority: CN
Inventors: 周学强; 王海明; 甄长征; 戴权; 高华清; 彭成洲
Original assignee: Jiangxi Hongtudi Chemical Co ltd; Yizhi Agricultural Technology Co ltd; Beijing Jintaiyi Crop Technology Co ltd
Current assignee: Jiangxi Hongtudi Chemical Co ltd; Yizhi Agricultural Technology Co ltd; Beijing Jintaiyi Crop Technology Co ltd
Priority date: 2022-11-10
Filing date: 2022-11-10
Publication date: 2023-03-21
Anticipated expiration: 2042-11-10
Also published as: CN115568472A

Abstract

The invention provides an insecticidal composition of benzpyrimoxan and diproprionate, wherein the mass ratio of benzpyrimoxan to diproprionate is (1); the composition has obvious synergistic effect on brown planthopper and aphid; when the composition shows a synergistic effect, the use dosage of the active ingredients can be effectively reduced, and the generation of drug resistance of pests is slowed down.

Description

Insecticidal composition containing benzpyrimoxan and diproprionate and application thereof

Technical Field

The invention relates to the technical field of pesticides, in particular to an insecticidal composition containing benzpyrimoxan and diproprionate and application thereof.

Background

Benzpyrimoxan is a novel insecticide developed by Nippon pesticide Co., ltd, and has the development code NNI-1501. The CAS number is 1449021-97-9, and the structural formula is

. Benzpyrimoxan is low in toxicity, has little influence on non-target organisms such as powdery insects and beneficial arthropods and has no mutagenicity. The action mechanism is not clear, but the development company is based on the unique chemical structure (containing benzyloxy and cyclic acetal on the pyrimidine group) and the prior insecticides of fipronil, ethofenprox, buprofezin,Imidacloprid and the like have no cross resistance and the like, and are presumed to have a novel action mechanism. The activity of benzpyrimoxan on rice planthopper nymphs is high, and the activity of benzpyrimoxan on rice tail hoppers is also high; the activity to other hemiptera pests is lower than that to rice planthopper, and the activity has extremely high selectivity to the rice planthopper; the field efficacy test result shows that: when the using amount of the effective components is 50-75g/hm < 2 >, the bentpyrimoxan product has good control effect on resistant brown planthopper, white-backed planthopper and the like; the pesticide is applied to brown planthopper in the egg stage and 1-3 instar nymph stage, so that the population growth can be controlled, and the lasting period is more than 3 weeks.

Dicyclopropyl, common english name: afidopytopen is a kind of Ruiecene pesticide, its structure is novel and has a completely new action mechanism, and can act by means of interfering regulation of insect vanillic acid transient receptor channel complex so as to interfere feeding and other behaviors of insect, and finally the insect is starved and died. The insecticidal composition has good lethal effect on piercing-sucking pests such as aphids, plant hoppers, scale insects and leafhoppers, and can be used for foliar spray, seed treatment and soil treatment; the dicyclopropionate dispersible liquid of the basf company is used by mixing water and spraying at the initial stage of aphid occurrence, the control effect is about 70-80% after the pesticide is applied for 1 day and about 80-90% after the pesticide is applied for 14-21 days under the dosage of 7.5-12g/hm < 2 > or 2.5-4.17mg/kg of the active ingredient, and the control effect is about 70-90% when the dicyclopronate dispersible liquid is used by mixing water and spraying at the initial stage of bemisia tabaci occurrence and under the dosage of 42.5-50g/hm < 2 >.

The synergistic compounding of the pesticide is an effective measure for expanding the control spectrum, improving the control effect and reducing the pesticide cost of farmers, and the research of the applicant finds that the blended preparation of benzpyrimoxan and diproprionate has strong synergistic effect; can effectively slow down the generation of drug resistance of pests, reduce the dosage of active ingredients and reduce environmental pollution.

Disclosure of Invention

The invention aims to provide a synergistic insecticidal composition which can effectively slow down the generation of drug resistance of pests, reduce the dosage of active ingredients and reduce environmental pollution.

The specific technical scheme is as follows:

the active ingredients of the insecticidal composition of benzpyrimoxan and diproprionate comprise benzpyrimoxan and diproprionate, and the mass ratio of benzpyrimoxan to diproprionate is 1.

Preferably, the mass ratio of benzpyrimoxan to the dicyclanil ester is 1. Preferably, the mass ratio of benzpyrimoxan to the dicyclanil ester is 1

The insecticidal composition comprises auxiliary material components. The preparation of the composition can be missible oil, wettable powder, suspending agent, granules, water dispersible granules, microemulsion, emulsion in water, microcapsule and water dispersible liquid.

The adjuvant is a wetting agent, a dispersing agent, an emulsifier, a thickener, a disintegrating agent, an antifreezing agent, an antifoaming agent, a solvent, a preservative, a stabilizer, a synergist, a carrier, etc., and may be added as appropriate according to the needs of the preparation, and may be changed according to different situations, and is not particularly limited.

The composition comprises the following components in percentage by weight when prepared into wettable powder: 0.5-50% of active ingredient, 1-10% of dispersing agent, 1-10% of wetting agent and filler for making up 100%. The active ingredients, the dispersant, the wetting agent and the filler are mixed, uniformly mixed in a mixing cylinder, crushed by a jet mill and uniformly mixed, and the wettable powder product of the composition can be prepared.

When the composition is prepared into water dispersible granules, the composition comprises the following components in percentage by weight: 0.5-50% of active ingredient, 1-10% of dispersing agent, 1-10% of wetting agent, 1-5% of disintegrating agent, 1-5% of binding agent and the balance of filler to 100%. The active ingredients, the dispersing agent, the wetting agent, the disintegrating agent, the filler and the like are crushed by airflow to obtain the required particle size, and other auxiliary agents such as the binder and the like are added to obtain the granulating material. And (3) quantitatively feeding the materials into a fluidized bed granulation dryer, and granulating and drying to obtain the water dispersible granule product of the composition.

The composition is prepared into a suspending agent and comprises the following components in percentage by weight: 0.5-50% of active ingredient, 1-10% of dispersant, 1-10% of wetting agent, 0.1-1% of defoaming agent, 0.1-3% of thickening agent, 0.1-5% of antifreeze agent and deionized water for making up 100%. The dispersant, the wetting agent, the defoaming agent, the thickening agent and the antifreeze in the formula materials are sheared and mixed uniformly at a high speed, the active ingredients are added, and the mixture is ball-milled in a ball mill for 2 to 3 hours to ensure that the particle size of particles is below 5 mu m, so that the suspending agent product of the composition is prepared.

The invention is mainly directed to crops such as corn, soybean, cotton, rape, rice, wheat, beet, oat, rye and barley. The pests comprise plant hoppers, whiteflies, leafhoppers, aphids, stem borers, thrips, cabbage caterpillars, prodenia lituras and the like.

The beneficial technical effects are as follows:

the composition of the invention has obvious synergistic effect on brown planthopper and aphid. When the composition shows a synergistic effect, the use dosage of the active ingredients can be effectively reduced, and the generation of drug resistance of pests is slowed down.

The preparation prepared by the invention has excellent field control effect on rice planthopper and wheat aphid.

Detailed Description

The present invention will be further explained with reference to specific embodiments.

Example 1 indoor toxicity test of Complex Agents against Nilaparvata lugens

A test insect source: collecting brown planthopper in the field and subculturing in an artificial climate chamber; collecting 2-3 instar nymphs of brown planthoppers for testing.

The test method comprises the following steps: the indoor toxicity is measured by a seedling soaking method. Virulence determinations are performed in a climatic chamber. Soaking rice seedling and root in medicinal liquid with different concentrations for 20s, taking out, wrapping the root with wet absorbent cotton, placing in glass test tube, inoculating 2-3-year-old nymph after 30min, and performing contrast treatment. Setting 7 concentrations of each medicament, setting 4 repetitions of each concentration, inoculating 20 nymphs of 2-3 years old, checking survival condition of test insects 24 h after medicament application, calculating mortality, comparing with control mortality, and calculating corrected mortality.

Mortality = number of dead insects/total number of insects tested × 100%

Corrected mortality = (treatment-control mortality)/(100-control mortality) × 100%.

And (3) carrying out data processing on the virulence determination data by adopting DPS statistical analysis software. Calculating according to analysis software to obtain an LC50 value; and evaluating the drug combination effect. The combined action mode adopts a method which is proposed in 1960 by Sun Yunpei et al and calculates the combined toxicity of the mixture through the toxicity index, namely a co-toxicity coefficient (CTC) method.

The co-toxicity coefficient is calculated as follows:

actually measured virulence index (ATI) = (standard medicament LC 50/test medicament LC 50) × 100;

theoretical virulence index (TTI) = a medicament ATI x percent of a in the mix + B medicament ATI x percent of B in the mix;

co-toxicity coefficient (CTC) = (ATI/TTI mix) × 100;

when the CTC is less than or equal to 80, the composition shows antagonism, when the CTC is more than 80 and less than 120, the composition shows additive action, and when the CTC is more than or equal to 120, the composition shows synergistic action.

Results and analysis

As can be seen from Table 1, the combination of Benzpyrimoxan and diproprionate showed additive or synergistic combination effect on Nilaparvata lugens. When the mass ratio of Benzpyrimoxan to the diproprionate is 1. When the mass ratio of Benzpyrimoxan to the diproprionate is 10. When the composition shows a synergistic effect, the use dosage of the active ingredients can be effectively reduced, and the generation of drug resistance of pests is slowed down.

Table 1: combined action test result of compound medicament on brown planthopper

Example 2 indoor toxicity test of Complex Agents against aphids

A test insect source: wheat aphids are collected in the field, and wingless adult aphids with the same individual size are selected for testing during experiments.

The test method comprises the following steps: the indoor toxicity is measured by dipping method. 7 concentrations were set for each agent, 4 replicates for each concentration, and a control treatment was set. Soaking 30-50 heads of wheat ears with wingless adult aphids in liquid medicine with certain concentration for 5s, taking out, absorbing and removing redundant liquid medicine, then placing the treated wheat ears in a culture dish paved with filter paper for culture, checking the total number of insects and the number of dead insects after 12h, and calculating the death rate and correcting the death rate.

Mortality = number of dead insects/total number of insects tested × 100%

Corrected mortality = (treatment mortality-control mortality)/(100-control mortality) × 100%.

The co-toxicity coefficient is calculated as follows:

co-toxicity coefficient (CTC) = (ATI/TTI mixed) x 100;

Results and analysis

As can be seen from Table 2, the combination of Benzpyrimoxan and diproprionate showed additive or synergistic combined effect on wheat aphid. When the mass ratio of Benzpyrimoxan to the diproprionate is 1. When the mass ratio of Benzpyrimoxan to diproprionate is 1. When the composition shows a synergistic effect, the use dosage of the active ingredients can be effectively reduced, and the generation of drug resistance of pests is slowed down.

Table 2: combined action determination result of compound medicament on wheat aphids

Formulation example 1

The 10% wettable powder comprises the following components in percentage by weight:

7.5 percent of Benzpyrimoxan, 2.5 percent of diproprionate, 3 percent of calcium dodecyl benzene sulfonate, 5 percent of sodium lignin sulfonate and bentonite, wherein the total content is 100 percent. The components are processed by a conventional method to prepare the 10 percent wettable powder.

Formulation example 2

The 8% wettable powder comprises the following components in percentage by weight:

benzpyrimoxan 2%, dicyclopropyl insect ester 6%, calcium dodecylbenzene sulfonate 1%, sodium lignosulfonate 4% and bentonite to make up 100%. The components are processed by a conventional method to prepare the 10 percent wettable powder.

Formulation example 3

12% of water dispersible granules, which comprise the following components in percentage by weight:

benzpyrimoxan 10%, dicyclopropyl 2%, morwet D425%, sodium lignosulfonate 3%, ammonium sulfate 2%, sodium carboxymethylcellulose 1%, white carbon black 2% and kaolin for 100%. The components are processed by a conventional method to prepare 6 percent wettable powder.

Formulation example 4

The 6% water dispersible granule comprises the following components in percentage by weight:

benzpyrimoxan 2%, dicyclopropyl 4%, morwet D425 3%, sodium lignosulfonate 2%, urea 2%, sodium carboxymethylcellulose 2%, white carbon black 3% and kaolin for 100%. The components are processed by a conventional method to prepare 6 percent wettable powder.

Formulation example 5

1.5% dispersible agent comprising the following components in weight percent:

benzpyrimoxan 1%, diproprionate 0.5%, agricultural milk 500%, SP2700 1%, sodium lignosulfonate 2%, propylene glycol 3%, sodium benzoate 0.5%, bentonite 0.2% and water for 1000%.

Formulation example 6

4% dispersible agent comprising the following components in weight percent:

benzpyrimoxan 2%, dicyclopropyl methyl 2%, agricultural milk 500%, SP2700 2%, sodium lignosulfonate 3%, propylene glycol 2%, sodium benzoate 0.5%, bentonite 0.5% and water for 1000%.

Example 3 field control of the Compound agent against Rice planthopper

Testing the medicament: formulation examples 2, 4, 5;

the test method comprises the following steps: setting a treatment group and a control group; randomized, repeated 4 times per treatment. The area of the cell is 66.7m2, and the treatment rooms are separated by mud ridges, so that the field water is prevented from streaming, and the accuracy of test data of each medicament is ensured. Spraying the pesticide in the full period of the rice planthopper nymphs by adopting a knapsack manual sprayer, wherein the caliber of a spray hole is 1.0mm, and the pesticide liquid amount is 50kg/667m < 2 >. And (4) surveying 5 points and 4 groups of rice planthopper population numbers of 20 groups of rice planthoppers in total by a parallel jumping method in each cell 14 days before and after the pesticide spraying, and calculating the control effect according to the natural population increase and decrease rate of the rice planthoppers in the control area.

The oral cavity decline rate = (number of insects before application-number of insects after application)/(number of insects before application) × 100%

Control effect = (treatment area population reduction rate-control area population reduction rate)/(100-control area population reduction rate) × 100%

Results and analysis: as can be seen from Table 3, the preparation prepared by the method has excellent field control effect on rice planthoppers when the dosage of the active ingredients is 2.0 g/mu, and the control effect is more than 90%.

Table 3: compound pesticide for field control of rice planthopper

Preparation	Effective compositionG/mu	Control effect%
			2	2.0	90.0
4	2.0	92.6
			5	2.0	95.8
CK	-	-

Example 4 field control of the Compound agent against Rice planthopper

Testing the medicament: formulation examples 2, 4, 5;

the test method comprises the following steps: setting a treatment group and a control group; randomized, repeated 4 times per treatment. Cell area 66.7m2. The weather is fine on the day of application, and there is no rainfall process during the test period. The number of aphids was investigated before application and the number of residual insects was investigated 7d after application. And (5) sampling at each cell, fixing 10 ears at each point, and investigating the number of aphids on the fixed ears. 50 plants were continuously investigated for each treatment, and the population reduction rate and the control effect were calculated as follows.

Results and analysis: as can be seen from Table 4, the preparation prepared by the method has excellent field control effect on wheat aphids when the dosage of the active ingredients is 2.0 g/mu, and the control effect is more than 87%.

Table 4: compound medicament has field control effect on wheat aphids

Preparation	Effective component g/mu	Control effect%
			1	1.0	91.3
3	1.0	87.5
			6	1.0	96.4
CK	-	-

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same.

Claims

1. The insecticidal composition of benzpyrimoxan and diproprionate is characterized in that active ingredients consist of benzpyrimoxan and diproprionate, and the mass ratio of benzpyrimoxan to diproprionate is 1.

2. The insecticidal composition according to claim 1, wherein the mass ratio of benzpyrimoxan to diproprionate is 1.

3. An insecticidal composition according to claim 1 or 2, characterized in that the composition comprises an adjuvant component.

4. An insecticidal composition according to claim 3, wherein the composition is formulated as an emulsifiable concentrate, a wettable powder, a suspension, a granule, a water dispersible granule, a microemulsion, an aqueous emulsion, a microcapsule or a water dispersible liquid.

5. Use of the pesticidal composition of claim 2 for controlling crop pests, including plant hoppers and aphids.