CN112136819A

CN112136819A - Bactericidal composition containing fenpicoxamid and penflufen

Info

Publication number: CN112136819A
Application number: CN201910557831.1A
Authority: CN
Inventors: 葛家成; 杨志鹏; 司国栋; 张永芳
Original assignee: Hailir Pesticides and Chemicals Group Co Ltd
Current assignee: Hailir Pesticides and Chemicals Group Co Ltd
Priority date: 2019-06-26
Filing date: 2019-06-26
Publication date: 2020-12-29
Anticipated expiration: 2039-06-26
Also published as: CN112136819B

Abstract

The invention relates to a sterilization composition containing fenpicoxamid and fluxapyroxad, which contains fenpicoxamid as an active ingredient and fluxad as an active ingredient, wherein the weight ratio of the fenpicoamid as the active ingredient to the fluxad as the active ingredient is 1:80-80: 1. The composition has high activity on various diseases of various crops, has the characteristics of synergism, small dosage and the like.

Description

Bactericidal composition containing fenpicoxamid and penflufen

Technical Field

The invention belongs to the technical field of pesticides, and relates to application of a bactericidal composition containing fenpicoxamid and penflufen to crop diseases.

Technical Field

CAS accession number of Fenpicoxamid: 517875-34-2, formula: c₃₁H₃₈N₂O₁₁(ii) a Chemical name: (3S,6S,7R,8R) -8-benzyl-3- {3- [ (isobutyryloxy) methoxy]-4-methoxypyridine-2-carboxamido } -6-methyl-4, 9-dioxo-1, 5-dioxononan-7-yl isobutyrate having the following chemical formula:

the Fenpicoxamid is derived from a natural compound UK-2A through fermentation, and has good toxicological characteristics; as the 1 st member of the novel pyridine amide type bactericide for grains; the bactericidal activity is exerted by inhibiting mitochondrial respiration at the site of the fungal complex IIIQi ubiquinone (i.e., coenzyme Q) bonding. Fenpicoxamid is not cross-resistant to current grain fungicides.

CAS accession number for Penflufen (Penflufen): 94793-67-8, molecular formula C₁₈H₂₄FN₃O, chemical name 2' - [ (RS) -1, 3-dimethylbutyl]-5-fluoro-1, 3-dimethylpyrazole-4-carboxanilide having the following chemical formula:

the penflufen is a succinate dehydrogenase inhibitor, mainly acts on a respiratory chain electron transfer complex II and blocks energy metabolism; can prevent and treat seed-borne and soil-borne basidiomycetes and ascomycetes diseases. The treated seeds can absorb penflufen in the germination process and conduct the penflufen to other parts of the plant body through xylem, so that the crop protection effect is achieved.

In the actual process of agricultural production, the most easily generated problem of preventing and treating diseases is the generation of drug resistance of pathogenic bacteria, and the blending of different varieties of components is a common method for preventing and treating the generation of the resistance of the pathogenic bacteria. Active ingredients with different action mechanisms are mixed, and whether the synergistic, addition or antagonistic action is realized is judged according to the actual application effect. In most cases, the pesticide mixing effect is additive effect, the real synergistic mixing is less, and especially the obvious synergistic mixing is less. The inventor finds that the blending of fenpicicoxamid and fluxapyroxad has good synergistic effect in a certain range, and relevant blending of fenpicicoxamid and fluxad is not reported at present.

Disclosure of Invention

The invention aims to provide a bactericidal composition containing fenpicoamid and fluxapyroxafen, which has a synergistic effect, low use cost and good control effect.

The technical scheme of the invention is as follows:

a bactericidal composition containing fenpicoxamid and fluxapyroxad comprises an active ingredient fenpicoxamid and an active ingredient fluxad;

further, the weight ratio of the active ingredient fenpicoxamid to the active ingredient fluxapyroxad is 1:80-80: 1;

further, the weight ratio of the active ingredient fenpicoxamid to the active ingredient fluxapyroxad is 1:50-50: 1;

further, the weight ratio of the active ingredient fenpicoxamid to the active ingredient fluxapyroxad is 1:20-20: 1;

further, the weight ratio of the active ingredient fenpicoxamid to the active ingredient fluxapyroxad is 1:5-10: 1;

further, the weight ratio of the active ingredient fenpicoxamid to the active ingredient fluxapyroxad is 1:3-3: 1;

further, the weight ratio of the active ingredient fenpicoxamid to the active ingredient fluxapyroxad is 1: 2.

The bactericide composition preparation can be prepared into a dosage form allowed by the pesticide field;

further, the composition comprises an active ingredient and an auxiliary ingredient of a pesticide preparation;

further, the auxiliary components of the pesticide preparation comprise a carrier and an auxiliary agent;

further, the carrier is any one, two or three of water, a solvent or a filler, and the water is preferably deionized water;

further, the solvent is selected from one or a mixture of more of N, N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octylpyrrolidone, ethanolamine, triethanolamine, isopropylamine, N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile;

further, the filler is selected from one or a mixture of more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;

furthermore, the auxiliary agent at least comprises a surfactant, and other functional auxiliary agents such as an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent, a defoaming agent and the like can be added according to different use occasions and requirements;

further, the surfactant is selected from one or more of an emulsifier, a dispersant, a wetting agent or a penetrant;

further, the other functional auxiliary agents are selected from one or more of an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent or a defoaming agent;

further, the emulsifier is selected from one or more of agricultural milk 500# (calcium alkyl benzene sulfonate), OP series phosphate ester (nonylphenol polyoxyethylene ether phosphate ester), 600# phosphate ester (phenylphenol polyoxyethylene ether phosphate ester), styrene polyoxyethylene ether ammonium sulfate salt, magnesium salt of alkyl diphenyl ether disulfonate, triethanolamine salt, agricultural milk 400# (benzyldimethylphenol polyoxyethylene ether), agricultural milk 700# (alkylphenol formaldehyde resin polyoxyethylene ether), Ningru 36# (phenethylphenol formaldehyde resin polyoxyethylene ether), agricultural milk 1600# (phenethylphenol polyoxyethylene polyoxypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), agricultural dehydrated milk 33# (alkylaryl polyoxyethylene polyoxypropylene ether), span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether) A mixture of seed constituents;

further, the dispersing agent is selected from one or a mixture of a plurality of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensate sulfate, calcium alkylbenzene sulfonate, naphthalene sulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene, fatty amine polyoxyethylene, fatty acid polyoxyethylene or glycerol fatty acid ester polyoxyethylene;

further, the wetting agent is selected from one or a mixture of more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrant F, Chinese honeylocust fruit powder, silkworm excrement or soapberry powder;

further, the penetrating agent is selected from a mixture consisting of one or more of penetrating agent JFC (fatty alcohol-polyoxyethylene ether), penetrating agent T (diisooctyl maleate sulfonate), azone or organic silicon;

further, the antifreezing agent is a mixture consisting of one or more of ethylene glycol, propylene glycol, glycerol or urea;

further, the thickening agent is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or magnesium aluminum silicate;

further, the stabilizer is selected from one or more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate and triphenyl phosphate;

further, the disintegrating agent is selected from one or more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate;

further, the defoaming agent is selected from one or a mixture of more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds;

all of the above are commercially available.

The sum of the contents of an active ingredient fenpicoamid and an active ingredient fluxapyroxad in the bactericidal composition is 1-90% of the total weight of the composition;

furthermore, the sum of the contents of the fenpicoxamid serving as an active ingredient and the penflufen serving as an active ingredient in the bactericidal composition is 10-50% of the total weight of the bactericidal composition.

The bactericidal composition can be prepared into preparations acceptable in pesticides according to a method known by a person skilled in the art, and the preparations comprise solid preparations, liquid preparations, seed treatment preparations and other preparations;

further, the solid preparation is powder, dispersible tablets, granules, soluble powder, soluble granules, soluble tablets, milk powder, milk granules, water dispersible granules, wettable powder, micro-capsule granules, powder, macro-granules and water dispersible tablets;

further, the liquid preparation is microcapsule suspending agent, dispersible agent, missible oil, emulsion granules, oil emulsion, emulsion powder, aqueous emulsion, microemulsion, dispersible oil suspending agent, oil dispersion powder, suspending agent, suspoemulsion, soluble agent and ultra-low volume liquid;

further, the seed treatment preparation is a suspended seed coating agent, a seed treatment dry powder agent, a seed treatment dispersible powder agent, a seed treatment suspending agent and a seed treatment liquid agent;

further, the other preparation is bait, concentrated bait, gas preparation, aerosol, smoke agent;

furthermore, the preparation formulation is preferably wettable powder, water dispersible granules and suspending agents.

Further, the composition is prepared into wettable powder, and the components and the content of the wettable powder are preferably as follows: fenpicoxamid 0.1-80%, fluxapyroxad 0.1-80%, dispersant 2-10%, wetting agent 2-10% and stuffing for the rest;

further, the composition is prepared into water dispersible granules, and the components and the content of the water dispersible granules are preferably as follows: fenpicoxamid 0.1-80%, fluxapyroxad 0.1-80%, dispersant 3-12%, wetting agent 1-8%, disintegrating agent 1-10%, and filler for the rest.

Further, the composition is prepared into a suspending agent, and the components and the content of the suspending agent are preferably as follows: fenpicoxamid 0.1-80%, fluxapyroxad 0.1-80%, dispersant 2-10%, wetting agent 2-10%, defoaming agent 0.01-2%, thickening agent 0-2%, antifreeze agent 0-8%, and deionized water to make up the balance;

the invention has the following advantages: 1) the synergistic effect is obvious, the components are not simply superposed in activity, and the drug effect is greatly improved; 2) the prevention and treatment efficacy is outstanding, the duration is long, and the resistance risk is small; 3) the field dosage of the active ingredients is reduced, the production and use cost is reduced, and the pesticide residue and the environmental pollution are reduced; 4) the pesticide consists of active ingredients with different action mechanisms, and the action sites are increased, thereby being beneficial to overcoming and delaying the generation of the drug resistance of diseases.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more concise and clear, the present invention is described with the following specific embodiments, but the present invention is by no means limited to these embodiments. The following described examples are only preferred embodiments of the present invention, which can be used to describe the present invention and should not be construed as limiting the scope of the present invention. It should be understood that any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Preparation of the preparation

EXAMPLE 1 20% fencloxamid fluxapyroxad wettable powder (1:3)

The formula is as follows: 5% fennocoxamid, 15% fluxapyroxad, 6% sodium lignosulfonate, 4% sodium dodecylbenzenesulfonate and kaolin for the rest;

the preparation method comprises the following steps: the active ingredients, the dispersing agent, the wetting agent and the filler are uniformly mixed, crushed by a jet mill and then uniformly mixed for the second time, and the wettable powder can be prepared.

Example 2: 15% fennocoxamid-fluxapyroxad wettable powder (1:2)

The formula is as follows: 5% of fennocoxamid, 10% of fluxapyroxad, 3% of sodium salt of a naphthalene sulfonic acid formaldehyde condensate, 3% of wetting penetrant F and white carbon black;

the preparation method comprises the following steps: the same as in example 1.

Example 3: 10% fennocoxamid-fluxapyroxad wettable powder (1:1)

The formula is as follows: 5% fennocoxamid, 5% fluxapyroxad, 5% alkylphenol polyoxyethylene succinate sulfonic acid, 4% sodium dodecyl benzene sulfonate and light carbonic acid to make up the balance;

the preparation method comprises the following steps: the same as in example 1.

Example 4: wettable powder of fennocoxamid-fluxapyroxad 40% (3:5)

The formula is as follows: 15% fennocoxamid, 25% fluxapyroxad, 4% dialkyl naphthalene sulfonate, 6% sodium lauryl sulfate and bentonite to make up the balance;

the preparation method comprises the following steps: the same as in example 1.

Example 5: 30% fennocoxamid-fluxapyroxad wettable powder (1:5)

The formula is as follows: 5% of fennocoxamid, 25% of fluxapyroxad, 6% of sodium naphthalene sulfonic acid formaldehyde condensate, 4% of sodium dodecyl benzene sulfonate and kaolin, and the balance of the components is complemented;

the preparation method comprises the following steps: the same as in example 1.

Example 6: 30% fennocoxamid fluxapyroxad aniline water dispersible granule (1:1)

The formula is as follows: 15% fennocoxamid, 15% fluxapyroxad, 6% fatty alcohol polyoxyethylene ether, 2% sodium dodecyl benzene sulfonate, 2% magnesium aluminum silicate, 0.5% sodium bicarbonate and white carbon black;

the preparation method comprises the following steps: the active ingredients, the dispersing agent, the wetting agent, the binder, the disintegrating agent and the filler are subjected to airflow crushing to obtain the required particle size, and then the particles are sent into a fluidized bed granulation dryer to be granulated and dried, so that the water dispersible granule can be prepared.

Example 7: 30% fennocoxamid fluxapyroxad aniline water dispersible granule (1:2)

The formula is as follows: 10% fennocoxamid, 20% fluxapyroxad, 3% octyl phenol polyoxyethylene ether sulfate, 2% nekal BX, 2% hydroxyethyl cellulose, 3% urea and white carbon black;

the preparation method comprises the following steps: the same as in example 6.

Example 8: 10% fennocoxamid fluxapyroxad aniline water dispersible granule (1:4)

The formula is as follows: 2% fennocoxamid, 8% fluxapyroxad, 4% fatty alcohol polyoxyethylene ether, 5% sodium dodecyl sulfate, 2% magnesium aluminum silicate, 2% aluminum chloride and pottery clay for the balance;

the preparation method comprises the following steps: the same as in example 6.

Example 9: 15% fennocoxamid fluxapyroxad aniline water dispersible granule (1:2)

The formula is as follows: 5% fennocoxamid, 10% fluxapyroxad, 4% fatty alcohol polyoxyethylene ether, 5% sodium dodecyl sulfate, 2% hydroxyethyl cellulose, 3% urea and white carbon black;

the preparation method comprises the following steps: the same as in example 6.

Example 10: 25% fennocoxamid fluxapyroxad aniline water dispersible granule (2:3)

The formula is as follows: 10% fennocoxamid, 15% penflufen, 4% fatty alcohol polyoxyethylene ether, 5% sodium dodecyl sulfate, 2% hydroxyethyl cellulose, 2% magnesium aluminum silicate, 2% aluminum chloride and pottery clay for the balance;

the preparation method comprises the following steps: the same as in example 6.

Example 11: 25% fennocoxamid fluxapyroxad aniline suspension (2:3)

The formula is as follows: 10% fennocoxamid, 15% fluxapyroxad, 2% sodium octylphenol polyoxyethylene ether sulfate, 3% saponin powder, 2% propylene glycol, 2% silicone oil and deionized water to make up the balance;

the preparation method comprises the following steps: the suspending agent is prepared by uniformly mixing the dispersing agent, the wetting agent, the defoaming agent, the thickening agent, the anti-freezing agent and other auxiliary agents through high-speed shearing, adding the active ingredients, complementing the balance with deionized water, and grinding in a ball mill for 2-3 hours until the particle size of particles is below 5 um.

Example 12: 15% fennocoxamid fluxapyroxad aniline suspension (2:1)

The formula is as follows: 10% fennocoxamid, 5% penflufen, 3% ester polyoxyethylene ether, 3% sodium dodecyl sulfate, 2% triethylene glycol, 2% organic silicon, 3% aluminum magnesium silicate and deionized water to make up the balance;

the preparation method comprises the following steps: the same as in example 11.

Example 13: 30% fennocoxamid fluxapyroxad aniline suspension (1:2)

The formula is as follows: 10% fennocoxamid, 20% fluxapyroxad, 2% sodium lignosulfonate, 3% sodium lauryl sulfate, 2% triethylene glycol, 4% organosilicon, 3% gelatin and deionized water to make up the balance;

Example 14: 20% fennocoxamid fluxapyroxad aniline suspension (1:1)

The formula is as follows: 10% fennocoxamid, 10% fluxapyroxad, 3% ester polyoxyethylene ether, 3% sodium dodecyl sulfate, 2% triethylene glycol, 4% organic silicon, 3% aluminum magnesium silicate and deionized water to make up the balance;

Example 15: 40% fennocoxamid fluxapyroxad aniline suspension (2:3)

The formula is as follows: 16% fennocoxamid, 24% penflufen, 3% ester polyoxyethylene ether, 3% sodium dodecyl sulfate, 2% triethylene glycol, 4% organic silicon, 3% gelatin and deionized water to make up the balance;

Indoor case of activity

Example 16: indoor activity against wheat powdery mildew by blending fenpicoamid and penflufen.

The test basis is as follows: NY/T1156.4-2006 agricultural chemical indoor bioassay test guidelines part 4 of fungicides: experimental potting method for preventing and treating wheat powdery mildew.

Test targets: erysiphe graminis (Erysiphe graminis).

The test instrument: electronic balance (sensory 0.1mg), spray apparatus, microscope, conical flask, pipette, graduated cylinder, blood count plate, counter, etc.

Preparing a test material: selecting susceptible wheat pot culture, and allowing the seedling to grow to 2-3 leaves.

Test agents: 94% fennocoxamid technical, 97% fluxapyroxad technical.

Preparing a medicament: the original medicine is dissolved by dimethyl formamide as a solvent, and the solution is diluted by 0.1% Tween 80 aqueous solution, and 5 series of mass concentrations are set.

Medicament treatment: and uniformly shaking off and inoculating powdery mildew fresh spores generated in 24 hours on ill wheat leaves on 2-3-leaf potted wheat seedlings to be treated. For each 3 pots treated, 10 wheat plants per pot. The dose spray was applied 24 hours after inoculation, 4 replicates per treatment, and a blank control was set.

Data investigation: and (5) carrying out graded investigation according to the blank control incidence condition. The following classification method was used:

level 0: no disease;

level 1: the area of the lesion spots accounts for less than 5% of the area of the whole leaf;

and 3, level: the area of the lesion spots accounts for 6 to 15 percent of the area of the whole leaf;

and 5, stage: the area of the lesion spots accounts for 16 to 25 percent of the area of the whole leaf;

and 7, stage: the area of the lesion spots accounts for 26-50% of the area of the whole leaf;

and 9, stage: the area of the lesion spots accounts for more than 50 percent of the area of the whole leaf.

Data statistical analysis: and calculating disease index and prevention and treatment effect of each treatment according to the investigated data. The calculation formula is as follows:

disease index ∑ (number of diseased leaves at each stage × number of relative stages)/(total number of leaves × 9) × 100

Preventing and treating effect (%) - (blank control disease index-treatment area disease index)/blank control disease index is multiplied by 100

Sun Yupei method: the synergy of the mixed medicament is evaluated according to the co-toxicity coefficient (CTC), namely the CTC is less than or equal to 80 and is antagonistic, the CTC is between 80 and 120 and is additive, and the CTC is more than or equal to 120 and is synergistic. The co-toxicity coefficient calculation formula is as follows:

the measured virulence index of the mixture is equal to the EC of the standard medicament₅₀EC of/mixture₅₀×100

The theoretical virulence index of the mixture is the virulence index of the medicament A, the percentage of the medicament A in the mixture, the virulence index of the medicament B and the percentage of the medicament B in the mixture

Co-toxicity coefficient (CTC) ═ actually measured virulence index of the mixture/theoretical virulence index of the mixture × 100

And (3) test results:

TABLE 1 Combined virulence results for the blending of fennocoxamid and fluxapyroxad on wheat powdery mildew

The test results are known (see table 1): when the proportion of fennocoxamid and fluxapyroxad in the mixture for preventing and treating wheat powdery mildew is 1:50-50:1, the cotoxicity coefficients are all larger than 80, which indicates that the two components are mixed within the range of 1:50-50:1 and show addition or synergistic action; the proportion of fennocoxamid and fluxapyroxad is 1:20-20:1, the co-toxicity coefficients are all larger than 120, and the synergistic effect is shown; the proportion of fennocoxamid and fluxapyroxad is 1:5-10:1, the synergistic effect is more prominent, and the co-toxicity coefficients are all more than 160; the proportion of fennocoxamid and penflufen is 1:3-3:1, the synergistic effect is more prominent, and the cotoxicity coefficient is more than 200. The inventor tests show that the preferable ratio of fenproxamid to fluxapyroxad is 1:20, 1:10, 1:5, 1:3, 1:2, 1:1, 2:1, 3:1, 5:1, 10:1 and 20: 1; wherein the synergistic effect is most prominent when the ratio of fennocoxamid to penflufen is 1:2, and the cotoxicity coefficient is 297.76.

Test of field drug effect

Example 17: and mixing fennocoxamid and penflufen to prevent and treat rice sheath blight.

The test basis is as follows: GB/T17980.20-2000 pesticide field efficacy test criterion (I) bactericide for preventing and treating rice sheath blight disease.

Test targets: rice sheath blight disease (Rhizoctonia solani); the rice variety 'Guangliangyou 15'.

Environmental conditions: the test field is arranged in a village at Huanghai county, the test field is sandy loam, the fertilizer water is medium, the previous crop is rice, the field is idle in winter, the management is consistent, irrigation conditions exist, rice sheath blight is medium and heavy, the management conditions of all districts are good, the growth vigor of the rice is good, and other pesticides are not applied before and after the test.

Test agents: 20% of fennocoxamid-fluxapyroxad aniline wettable powder, 30% of fennocoxamid-fluxad aniline water dispersible granules and 20% of fennocoxamid-fluxad aniline suspending agent.

Control agents: 10% fennocoxamid suspending agent, 20% fluxapyroxad water dispersible granules and clear water control.

Cell area and repetition: the cell area was 20 square meters, with 4 repetitions per treatment.

The application method comprises the following steps: the dosage of the pesticide is converted into the dosage of each cell according to 750 liters of pesticide liquid per hectare, and the basal part of the rice cluster is sprayed as much as possible on the premise of ensuring thorough penetration during pesticide spraying, so that the diseased part is fully applied with pesticide. The application is started 7 months and 8 days at the early stage of rice sheath blight, and the second application is carried out after 7 days (7 months and 15 days) for 2 times.

Investigation and recording: the disease condition base was investigated before the drug (day 7/8), the intermediate-stage results were investigated 7 days (day 7/15) after the first drug, and the final results were investigated 14 days (day 7/29) after the 2 nd drug.

Sampling is performed at 5 points on each cell diagonal, 5 clusters are surveyed at each point, and 25 clusters are counted. The survey was conducted using 0-9 grade grading standards. The classification method comprises the following steps:

level 0: the whole plant is disease-free;

level 1: the fourth leaf and the leaf sheaths and leaves below the fourth leaf (sword leaf is taken as the first leaf);

and 3, level: the third leaf and the leaf sheaths and leaves below the third leaf are attacked;

and 5, stage: the second leaf and the leaf sheaths and leaves below the second leaf are attacked;

and 7, stage: attack of Jianye leaf and the leaf sheaths and leaves below the Jianye leaf;

and 9, stage: the whole plant is attacked and withered in advance.

The pharmacodynamic calculation mode is as follows:

disease index ∑ (number of diseased stems at each stage × number of relative stages)/(total stem number × 9) × 100

Control effect (%) [1- (control area pre-drug disease index x treatment area post-drug disease index)/(control area post-drug disease index x treatment area pre-drug disease index) ] × 100

And (3) test results:

table 2 shows the control effect of the fennocoxamid and fluxapyroxad mixed and matched rice sheath blight disease

The field efficacy test shows (see table 2), 7 days after the 1 st drug, the control effects of fenproxamid and fluxapyroxad on rice sheath blight are 67.6%, 80.0% and 76.8% respectively, which are superior to the control effect of a single agent; 14 days after the second pesticide, the control effects of fenpicoamid and fluxapyroxad on rice sheath blight are respectively 74.4%, 87.2% and 83.1%, which are obviously better than the control effect of a single preparation.

Example 18: fennocoamid and fluxapyroxad mixed for preventing and treating wheat powdery mildew

The test basis is as follows: GB/T17980.22-2000 pesticide field efficacy test criterion (I) bactericide for preventing and treating cereal powdery mildew.

Test targets: wheat powdery mildew (Wheat powdery mildew); the wheat variety 'Xiaoyan-22'.

Environmental conditions: the test is carried out in a temple village wheat field in Mei town of Mei county, Shanxi Bao chicken city, the winter irrigation is carried out for 1 time, and the management level is general.

The application method comprises the following steps: the application is started 5 months and 8 days in the early stage of the wheat powdery mildew, and the second application is carried out 2 times after 7 days (5 months and 15 days).

Investigation and recording: the disease condition base was investigated before the drug (day 8/5), the intermediate-stage results were investigated 7 days after the first drug (day 15/5), and the final results were investigated 7 days after the 2 nd drug (day 22/5).

Sampling is carried out at 5 points on the diagonal of each cell, 0.25 square meters is investigated at each point, and the first leaf below the flag leaf level of each plant is investigated. The classification method comprises the following steps:

level 0: no disease;

The pharmacodynamic calculation mode is as follows:

And (3) test results:

TABLE 3 prevention and treatment of wheat powdery mildew by blending fennocoxamid with penflufen

The test results show (see table 3): 7 days after the last application, the treatment of fennocoxamid and fluxapyroxad shows good control effects on wheat powdery mildew, wherein the control effects are 78.88%, 84.18% and 78.58% respectively, and are superior to the control effects of single agents, namely 74.18% and 73.90%.

Claims

1. A bactericidal composition containing fenpicoxamid and fluxapyroxad is characterized by comprising the active ingredients of fenpicoxamid and fluxad.

2. The bactericidal composition of claim 1, wherein the weight ratio of the active ingredients fenpicoxamid to fluxapyroxad is from 1:80 to 80: 1.

3. The bactericidal composition of claim 1, wherein the weight ratio of the active ingredients fenpicoxamid to fluxapyroxad is from 1:50 to 50: 1.

4. The bactericidal composition of claim 1, wherein the weight ratio of the active ingredients fenpicoxamid to fluxapyroxad is from 1:20 to 20: 1.

5. The bactericidal composition of claim 1, wherein the weight ratio of the fenpicicoxamid active ingredient to the fluxapyroxad active ingredient is from 1:3 to 3: 1.

6. The bactericidal composition of claim 1, wherein the weight ratio of the fenpicoxamid active ingredient to the fluxapyroxad active ingredient is 1: 2.

7. The bactericidal composition of claim 1, wherein the sum of the active ingredients in the composition is from 1% to 90%, preferably from 10% to 50%, of the total weight of the composition.

8. The bactericidal composition of claim 1, wherein the composition is formulated into any dosage form suitable for agricultural use; preferably, the dosage form comprises any one of powder, dispersible tablet, granule, soluble powder, soluble granule, soluble tablet, emulsion powder, emulsion granule, water dispersion granule, wettable powder, microcapsule granule, powder, large granule, water dispersion tablet, microcapsule suspension, dispersible liquid, missible oil, emulsion granule, oil emulsion, emulsion in water, microemulsion, dispersible oil suspension, oil dispersion powder, suspension, suspoemulsion, soluble liquid, ultra-low volume liquid, suspension seed coating agent, dry seed treatment powder, dispersible seed treatment powder, suspension for seed treatment, and liquid for seed treatment; the preferable preparation formulation is wettable powder, water dispersible granules and suspending agent.

9. Use of the fungicidal composition according to any one of claims 1 to 8 for controlling crop diseases;

preferably, the crop is a gramineous crop;

preferably, the crop is rice and/or wheat;

preferably, the crop diseases are wheat powdery mildew and/or rice sheath blight.

10. A method for controlling crop diseases, which is characterized in that the bactericidal composition as defined in any one of claims 1 to 8 is sprayed on the surfaces of crops or is uniformly stirred with crop seeds.